keyword
MENU ▼
Read by QxMD icon Read
search

Luteolin AND Diabetes

keyword
https://www.readbyqxmd.com/read/27904046/cocl2-decreases-ec-sod-expression-through-histone-deacetylation-in-cos7-cells
#1
Shuhei Hattori, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi
Extracellular-superoxide dismutase (EC-SOD), one of the SOD isozymes, is negatively regulated under hypoxic conditions, and decreases in its expression may exacerbate vascular diseases. Moreover, epigenetics, such as DNA methylation and histone modifications, are known to play a critical role in the progression of cancer, type 2 diabetes, and atherosclerosis. We previously investigated the involvement of reactive oxygen species (ROS) and p38 mitogen-activated protein kinase (MAPK) in decreases in EC-SOD expression in hypoxic COS7 cells; however, the role of epigenetics in this process currently remains unknown...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27872708/anti-hyperglycaemic-and-antioxidant-effects-of-bidens-tripartita-and-quantitative-analysis-on-its-active-principles
#2
Nilüfer Orhan, Ülkü Gökçen İçöz, Levent Altun, Mustafa Aslan
OBJECTIVES: Bidens species are used for their antidiabetic properties traditionally in many countries. Aim of this study is to evaluate hypoglycaemic and antidiabetic activity of Bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. MATERIALS AND METHODS: Hypoglycaemic effects of B. tripartita extract and its sub-extracts were investigated in normal and glucose-hyperglycaemic rats. Streptozotocin induced diabetic rats were used to examine antidiabetic activity of the extract and its sub-extracts after acute and sub-acute administration...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27809830/the-ethyl-acetate-fraction-of-corn-silk-exhibits-dual-antioxidant-and-anti-glycation-activities-and-protects-insulin-secreting-cells-from-glucotoxicity
#3
Chia-Chuan Chang, Wei Yuan, Hsiao-Yuh Roan, Jia-Ling Chang, Hsiu-Chen Huang, Yu-Ching Lee, Huey Jen Tsay, Hui-Kang Liu
BACKGROUND: In this study, we aimed to develop a Stigmata Maydis (corn silk) fraction with dual bio-activities against oxidative stress and protein glycation to protect β-cells from diabetes-induced failure. METHODS: Corn silk fractions were prepared by partition and chemically characterised by thin-layer chromatography. Free radical scavenging assay, glycation assay, and cell-based viability test (neutral red) were employed to decide the best fraction. Cell death analysis was executed by annexin V/ Propidium iodide staining...
November 3, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27594892/antidiabetic-properties-bioactive-constituents-and-other-therapeutic-effects-of-scoparia-dulcis
#4
REVIEW
Geethi Pamunuwa, D Nedra Karunaratne, Viduranga Y Waisundara
This review discusses the antidiabetic activities of Scoparia dulcis as well as its antioxidant and anti-inflammatory properties in relation to the diabetes and its complications. Ethnomedical applications of the herb have been identified as treatment for jaundice, stomach problems, skin disease, fever, and kidney stones, reproductory issues, and piles. Evidence has been demonstrated through scientific studies as to the antidiabetic effects of crude extracts of S. dulcis as well as its bioactive constituents...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27396410/structure-activity-relationship-study-reveals-benzazepine-derivatives-of-luteolin-as-new-aldose-reductase-inhibitors-for-diabetic-cataract
#5
Jomon Sebastian
Hyperglycaemia in diabetic patients causes diverse range of complications and the earliest among them is diabetic cataract. The role of aldose reductase, the key enzyme in polyol pathway, is well known in the genesis of cataract in chronic diabetic patients. Controlling of sorbitol flux into lens epithelial cells through aldose reductase inhibitors is an important treatment strategy. Due to the side-effects of many drugs so far developed, the development of aldose reductase inhibitors from natural sources has gained considerable attention...
June 30, 2016: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/27377644/luteolin-reduces-obesity-associated-insulin-resistance-in-mice-by-activating-ampk%C3%AE-1-signalling-in-adipose-tissue-macrophages
#6
Lei Zhang, Yi-Jing Han, Xian Zhang, Xin Wang, Bin Bao, Wei Qu, Jian Liu
AIMS/HYPOTHESIS: Inflammatory polarisation of adipose tissue macrophages (ATMs) plays a critical role in the development of obesity-associated metabolic diseases such as insulin resistance and diabetes. Our previous study indicated that dietary luteolin (LU) could prevent the establishment of insulin resistance in mice fed a high-fat diet (HFD). Here, we further investigated the effects of LU, which is a natural flavonoid, on pre-established insulin resistance and obesity-associated ATM polarisation in mice...
October 2016: Diabetologia
https://www.readbyqxmd.com/read/27322221/high-resolution-%C3%AE-glucosidase-inhibition-profiling-combined-with-hplc-hrms-spe-nmr-for-identification-of-antidiabetic-compounds-in-eremanthus-crotonoides-asteraceae
#7
Eder Lana E Silva, Jonathas Felipe Revoredo Lobo, Joachim Møllesøe Vinther, Ricardo Moreira Borges, Dan Staerk
α-Glucosidase inhibitors decrease the cleavage- and absorption rate of monosaccharides from complex dietary carbohydrates, and represent therefore an important class of drugs for management of type 2 diabetes. In this study, a defatted ethyl acetate extract of Eremanthus crotonoides leaves with an inhibitory concentration (IC50) of 34.5 μg/mL towards α-glucosidase was investigated by high-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR. This led to identification of six α-glucosidase inhibitors, namely quercetin (16), trans-tiliroside (17), luteolin (19), quercetin-3-methyl ether (20), 3,5-di-O-caffeoylquinic acid n-butyl ester (26) and 4,5-di-O-caffeoylquinic acid n-butyl ester (29)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27221336/luteolin-alleviates-methylglyoxal-induced-cytotoxicity-in-osteoblastic-mc3t3-e1-cells
#8
Kwang Sik Suh, Suk Chon, Eun Mi Choi
Methylglyoxal (MG), a reactive sugar-derived metabolite, exerts harmful effects by inducing oxidative stress, which aggravates a series of diabetic complications, including osteoporosis. The present study was performed to examine the effects of luteolin, a dietary polyphenolic flavonoid, on MG-induced cytotoxicity in MC3T3-E1 osteoblastic cells. Pretreatment of MC3T3-E1 osteoblastic cells with luteolin prevented MG-induced cell death and production of tumor necrosis factor-alpha, intracellular reactive oxygen species, mitochondrial superoxide, and cardiolipin peroxidation...
December 2016: Cytotechnology
https://www.readbyqxmd.com/read/27196298/lonicerae-japonicae-flos-attenuates-diabetic-retinopathy-by-inhibiting-retinal-angiogenesis
#9
Lingyu Zhou, Tianyu Zhang, Bin Lu, Zengyang Yu, Xiyu Mei, Palida Abulizi, Lili Ji
ETHNOPHARMACOLOGICAL RELEVANCE: Lonicerae Japonicae Flos (Jin-Yin-Hua) is a well-known traditional Chinese medicine used for clearing away heat and toxic material. AIM OF THE STUDY: This study aims to observe the attenuation of aqueous extract of Lonicerae Japonicae Flos (FL) against streptozotocin (STZ)-induced diabetic retinopathy (DR) and its engaged mechanism. MATERIALS AND METHODS: STZ-induced proliferative DR (PDR) for 5 month in C57BL/6 mice was used in this study...
August 2, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27170065/anti-diabetic-effects-of-luteolin-and-luteolin-7-o-glucoside-on-kk-a-y-mice
#10
Yanqing Zang, Kiharu Igarashi, Yu Li
Anti-diabetic potential of luteolin (LU) and luteolin-7-O-glucoside (LUG) were investigated in the amount of equimolar on KK-A(y) mice. The results showed that both of LU and LUG significantly improved blood glucose, HbA1c, insulin, and HOMR-IR levels. Anti-inflammatory and anti-oxidative effects of the LU and LUG were also proved. Furthermore, TGs in serum and liver were significantly decreased in the LU and LUG groups, as well as the mRNA expression of fat acid expression-related genes (SREBP-1c), compared to the basal diet group (CON)...
August 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27135143/the-flavone-luteolin-inhibits-liver-x-receptor-activation
#11
Vera Francisco, Artur Figueirinha, Gustavo Costa, Joana Liberal, Isabel Ferreira, Maria C Lopes, Carmen García-Rodríguez, Maria T Cruz, Maria T Batista
Luteolin is a dietary flavonoid with medicinal properties including antioxidant, antimicrobial, anticancer, antiallergic, and anti-inflammatory. However, the effect of luteolin on liver X receptors (LXRs), oxysterol sensors that regulate cholesterol homeostasis, lipogenesis, and inflammation, has yet to be studied. To unveil the potential of luteolin as an LXRα/β modulator, we investigated by real-time RT-PCR the expression of LXR-target genes, namely, sterol regulatory element binding protein 1c (SREBP-1c) in hepatocytes and ATP-binding cassette transporter (ABC)A1 in macrophages...
May 27, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/26989282/biphasic-response-to-luteolin-in-mg-63-osteoblast-like-cells-under-high-glucose-induced-oxidative-stress
#12
Naser Abbasi, Afra Khosravi, Ali Aidy, Massoumeh Shafiei
BACKGROUND: Clinical evidence indicates the diabetes-induced impairment of osteogenesis caused by a decrease in osteoblast activity. Flavonoids can increase the differentiation and mineralization of osteoblasts in a high-glucose state. However, some flavonoids such as luteolin may have the potential to induce cytotoxicity in osteoblast-like cells. This study was performed to investigate whether a cytoprotective concentration range of luteolin could be separated from a cytotoxic concentration range in human MG-63 osteoblast-like cells in high-glucose condition...
March 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/26973183/-biological-activity-and-mechanisms-of-therapeutic-action-of-rosmarinic-acid-luteolin-and-its-sulphated-derivatives
#13
REVIEW
A M Popov, O N Krivoshapko, A A Klimovich, A A Artyukov
The review considers recent experimental studies of biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives in diseases associated with disorders of carbohydrate and lipid metabolism. Particular attention is focused on the results of studies showing a high therapeutic potential of these phenolic compounds in their prophylactic and therapeutic use at experimental modeling of type 2 diabetes and hyperlipidemia. Based on the analysis of our results and the literature data putative mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives have been proposed...
January 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/26970570/chrysoeriol-and-other-polyphenols-from-tecoma-stans-with-lipase-inhibitory-activity
#14
Guillermo Ramirez, Alejandro Zamilpa, Miguel Zavala, Julia Perez, Dulce Morales, Jaime Tortoriello
ETHNOPHARMACOLOGICAL RELEVANCE: Tecoma stans is traditionally used by several ethnical groups in Mexico and Central America to treat diabetes. This species is mentioned in the majority of the ethnopharmacological studies compiled in Mexico focused in medicinal plants used as anti-diabetic treatment. AIM OF THE STUDY: Recently, this plant was found to display a high level of pancreatic lipase inhibitory activity, in addition to the several action mechanisms already described...
June 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26882973/high-resolution-ptp1b-inhibition-profiling-combined-with-high-performance-liquid-chromatography-high-resolution-mass-spectrometry-solid-phase-extraction-nuclear-magnetic-resonance-spectroscopy-proof-of-concept-and-antidiabetic-constituents-in-crude-extract
#15
Yousof Tahtah, Sileshi G Wubshet, Kenneth T Kongstad, Allison Maree Heskes, Irini Pateraki, Birger Lindberg Møller, Anna K Jäger, Dan Staerk
Type 2 diabetes (T2D) constituted 90% of the global 387 million diabetes cases in 2014. The enzyme protein-tyrosine phosphatase 1B (PTP1B) has been recognized as a therapeutic target for treatment of T2D and its adverse complications. With the aim of accelerating the investigation of complex natural sources, such as crude plant extracts, for potential PTP1B inhibitors, we have developed a bio-analytical platform combining high-resolution PTP1B inhibition profiling and high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy, i...
April 2016: Fitoterapia
https://www.readbyqxmd.com/read/26640536/assessment-of-the-potential-health-benefits-of-certain-total-extracts-from-vitis-vinifera-aesculus-hyppocastanum-and-curcuma-longa
#16
Denisa Margină, Octavian Tudorel Olaru, Mihaela Ilie, Daniela Grădinaru, Claudia GuȚu, Sorina Voicu, Anca Dinischiotu, Demetrios A Spandidos, Aristidis M Tsatsakis
A number of recent studies have illustrated the active role of food/natural components in the prevention of chronic diseases and in the improvement of the quality of life. In the present study, we aimed to obtain and characterize certain extracts from Vitis vinifera L., Aesculus hippocastanum L. and Curcuma longa L., focusing on their antioxidant effects in vitro. Three vegetal extracts were obtained for each plant: in water, 50% water-alcohol and in 96% ethanol. These extracts were then analyzed for their qualitative composition by high performance thin layer chromatography (HPTLC) and total phenolic content by ultraviolet-visible spectrophotometry (UV-VIS)...
November 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26633339/enrichment-and-purification-of-polyphenol-extract-from-sphallerocarpus-gracilis-stems-and-leaves-and-in-vitro-evaluation-of-dna-damage-protective-activity-and-inhibitory-effects-of-%C3%AE-amylase-and-%C3%AE-glucosidase
#17
Tingting Ma, Xiangyu Sun, Chengrui Tian, Jiyang Luo, Cuiping Zheng, Jicheng Zhan
An efficient preparative separation method for Sphallerocarpus gracilis stems and leaves polyphenols (SGslP) was established in this study. An X-5 macroporous adsorption resin was selected for the purification of the SGslP, and the polyphenol content of the purified SGslP (PSGslP) was increased 5.11-fold from 8.29% to 42.38% after one treatment run. The chemical composition of the PSGslP was analyzed by HPLC-MS/MS, and the predominant compounds were found to be luteolin-7-glucoside, acacetin-7-acetyglycoside and its isomers...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26617718/luteolin-improves-the-impaired-nerve-functions-in-diabetic-neuropathy-behavioral-and-biochemical-evidences
#18
Ming Li, Qiang Li, Qingsong Zhao, Jinchao Zhang, Jiang Lin
Peripheral neuropathies are a major cause of morbidity in patients with diabetes mellitus. Up to now, drugs for improving the impaired nerve functions has been lacking for diabetic neuropathy. The antioxidant and neuroprotective effects of luteolin make it an attractive candidate for diabetic neuropathy. The present study was designed to investigate the putative beneficial effect of luteolin on diabetic neuropathy. Diabetic rats were intraperitoneally treated with daily luteolin (50 mg/kg, 100 mg/kg and 200 mg/kg) or vehicle for 3 weeks from the 28(th) day after streptozotocin injection...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26459282/effect-of-luteoin-in-delaying-cataract-in-stz-induced-diabetic-rats
#19
Yuan Chen, Xiao-Bo Sun, Hong-E Lu, Fang Wang, Xiao-Hui Fan
Luteolin, a flavonoid rich in many plants, has shown various pharmacological effects including anti-inflammation, anti-oxidant, anti-tumor, cardioprotective and neuroprotective properties. At present, inflammation and oxidative stress have been recognized to be two important contributing factors to the development of diabetic cataract. The aim of this study is to investigate the effects of luteolin on diabetes-induced oxidative stress and inflammation in the lens of rats. A diabetic rat model was induced by intraperitoneally giving streptozotocin at a dosage of 60 mg/kg, and then the rats were treated by orally administration of luteolin 25, 50 and 100 mg/kg for 12 weeks...
October 13, 2015: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/26246742/luteolin-is-a-bioflavonoid-that-attenuates-adipocyte-derived-inflammatory-responses-via-suppression-of-nuclear-factor-%C3%AE%C2%BAb-mitogen-activated-protein-kinases-pathway
#20
Sarmila Nepali, Ji-Seon Son, Barun Poudel, Ji-Hyun Lee, Young-Mi Lee, Dae-Ki Kim
BACKGROUND: Inflammation of adipocytes has been a therapeutic target for treatment of obesity and metabolic disorders which cause insulin resistance and hence lead to type II diabetes. Luteolin is a bioflavonoid with many beneficial properties such as antioxidant, antiproliferative, and anti-cancer. OBJECTIVES: To elucidate the potential anti-inflammatory response and the underlying mechanism of luteolin in 3T3-L1 adipocytes. MATERIALS AND METHODS: We stimulated 3T3-L1 adipocytes with the mixture of tumor necrosis factor-α, lipopolysaccharide, and interferon-γ (TLI) in the presence or absence of luteolin...
July 2015: Pharmacognosy Magazine
keyword
keyword
100924
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"