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Andrea D Olivas, Jerome Taxy, Rebecca Wolsky, Tatjana Antic
Phyllodes tumor of the prostate is a rare mesenchymal tumor conventionally regarded as a stromal tumor of undetermined malignant potential. While the initial presentation is that of urinary obstruction and/or hematuria, the subsequent clinical behavior is thought to be a function of stromal cellularity and cytologic changes of malignancy. Of histologic interest, the epithelial component of this tumor varies, including intestinal metaplasia, as seen in the present case.
March 14, 2018: American Journal of Surgical Pathology
Bjørg Y Aksnessæther, Arne Solberg, Olbjørn H Klepp, Tor Åge Myklebust, Eva Skovlund, Solveig Roth Hoff, Lars J Vatten, Jo-Åsmund Lund
PURPOSE: Prostate cancer (PC) patients who undergo antiandrogen monotherapy are offered prophylactic radiation therapy (PRT) to the breast buds to avoid gynecomastia. The aim of the present study was to evaluate whether the risk of breast cancer (BC) in men with PC as their first cancer diagnosis was influenced by PRT. METHODS AND MATERIALS: From the Norwegian Cancer Registry, we collected data from all patients with PC as their first cancer diagnosis from 1997 to 2014...
February 5, 2018: International Journal of Radiation Oncology, Biology, Physics
M F Rodrigues, P T Truong, E C McKevitt, L M Weir, M A Knowling, E S Wai
PURPOSE: Phyllodes tumors of the breast are uncommon fibroepithelial lesions for which optimal management remains unclear. This retrospective population-based study reports treatment and outcomes for patients with phyllodes tumors and evaluates characteristics that influence outcome. MATERIALS AND METHODS: Data were analysed on 183 patients with newly diagnosed phyllodes tumors from 1999 to 2014. Five-year Kaplan-Meier local recurrence and survival were compared between cohorts with benign (n=83), borderline (n=50) and malignant phyllodes tumor (n=49) histology...
March 7, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Julia Y S Tsang, Yau-Kam Hui, Michelle A Lee, Maribel Lacambra, Yun-Bi Ni, Sai-Yin Cheung, Cherry Wu, Ava Kwong, Gary M K Tse
Phyllodes tumor (PT) of the breast is a rare but clinically important fibroepithelial tumor with potential risks of recurrence and metastasis. Recent studies identified recurrent TERT promoter mutations in PTs. However, the clinical significance of this alteration has not been fully examined. Two hundred and seven PTs from two intuitions were included. All cases were subjected to immunohistochemical analysis for TERT expression. Analysis of TERT promoter mutations was further performed by Sanger sequencing targeting the hotspot mutation region on cases from one of the involved institutions...
March 1, 2018: Scientific Reports
Stefanie Woodard, Susann Schetter, Karmaine Millington
Fibroadenomas are abundantly reported in the literature with several papers documenting the natural progression and clinical outcomes of thousands of cases. Juvenile fibroadenomas (also called cellular fibroadenomas) are frequently characterized by rapid growth, often described as 5-10 cm in size. They constitute approximately 7%-8% of fibroadenomas. They often measure greater than 5 cm. Pathologically, they show similar features to fibroadenomas but can resemble phyllodes. There have been few documented cases of breast masses in early childhood...
February 2018: Radiology Case Reports
S-A Lui, H B Oh, S Wang, C W Chan
Ductal carcinoma in situ arising within a benign phyllodes tumour is a rare neoplasm of the breast. We present a case of a 19-year-old woman who had a right breast lump for six months with the above diagnosis together with a mini-review of the literature. Ultrasound revealed a 5-cm breast lump and core biopsy revealed ductal carcinoma in situ. She underwent wide local excision of the breast lump with clear margins. Final histology confirmed ductal carcinoma in situ within a fibroepithelial lesion consistent with a benign phyllodes tumour...
February 27, 2018: Annals of the Royal College of Surgeons of England
Lisa R Shah-Patel
Malignant phyllodes tumor is a rare tumor of the breast occurring in females usually between the ages of 35 and 55 years. It is often difficult to distinguish benign from malignant phyllodes tumors from other benign entities such as fibroadenomas. This case presentation demonstrates a woman with malignant phyllodes tumor treated with mastectomy with abdominal skin flap reconstruction.
December 2017: Radiology Case Reports
J D J Gilbert, A Wells, S J Simpson
Costs and benefits of group living are a fundamental topic in behavioural ecology. Resource availability affects individuals' breeding prospects alone and in groups, as well as how reproduction is distributed within groups ("reproductive skew"). Here, in facultatively social thrips, we provide correlational evidence that breeding resources are associated with (1) whether solitary or social living is favoured, and (2) the degree of ovarian skew. Dunatothrips aneurae (Thysanoptera, Phlaeothripidae) cooperatively build silk "domiciles" on Australian Acacias, feeding exclusively from internal phyllode surfaces...
February 26, 2018: Scientific Reports
Hassan Alyami, Emad Al-Osail, Shawgi Harbi, Mohammed Bu Bshait
INTRODUCTION: Benign Osseous metaplasia of the breast is rare, with only a few cases reported in the literature. Here we present a case of benign osseous metaplasia of the breast presenting as a breast lump. CASE PRESENTATION: 38-year-old previously well woman presented with a one-year history of bilateral breast pain and a left-sided breast lump. Ultrasound and mammography suggested calcified fibroadenoma. An ultrasound-guided true cut biopsy revealed fibrous tissue containing foci of adenosis in the presence of a myoepithelial cell layer...
February 19, 2018: International Journal of Surgery Case Reports
Ali İbrahim Sevinç, Süleyman Özkan Aksoy, Merih Güray Durak, Pınar Balcı
Background/aim: Phyllodes tumors (PTs) of the breast are rare, and their diagnosis and treatment remain controversial. This retrospective study aims to examine the clinical outcome of benign and borderline PTs, according to the surgical margins. Materials and methods: We examined the medical records of 122 patients in our clinic, who had histologically confirmed benign and borderline PTs between 1994 and 2017. Results: The mean age of the patients was 40.6 years (range 18.0-81.0, ±12.1 standard deviation [SD]) and the mean tumor size was 25...
February 23, 2018: Turkish Journal of Medical Sciences
Zhi-Rui Zhou, Chen-Chen Wang, Xiang-Jie Sun, Zhao-Zhi Yang, Xing-Xing Chen, Zhi-Ming Shao, Xiao-Li Yu, Xiao-Mao Guo
The aim of this study was to explore the independent prognostic factors related to postoperative recurrence-free survival (RFS) in patients with breast phyllodes tumors (PTBs). A retrospective analysis was conducted in Fudan University Shanghai Cancer Center. According to histological type, patients with benign PTBs were classified as a low-risk group, while borderline and malignant PTBs were classified as a high-risk group. The Cox regression model was adopted to identify factors affecting postoperative RFS in the two groups, and a nomogram was generated to predict recurrence-free survival at 1, 3, and 5 years...
February 26, 2018: Cancer Medicine
Michiyo Saimura, Kenichiro Koga, Keisei Anan, Shoshu Mitsuyama, Sadafumi Tamiya
BACKGROUND: Breast carcinoma arising in a benign fibroepithelial tumor is rare, and is usually discovered incidentally during examination of the breast mass. METHODS: We evaluated the clinicopathological features, treatment, and prognosis of seven women with breast carcinomas within benign fibroepithelial tumors, diagnosed and treated at a single institution between 2011 and 2015. RESULTS: Seven women, aged 21-64 years, visited our hospital complaining of a breast mass detected by self-checking or screening examination...
February 19, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Elzbieta Slodkowska, Sharon Nofech-Mozes, Bin Xu, Carlos Parra-Herran, Fang-I Lu, Simon Raphael, Judit Zubovits, Wedad Hanna
Mammary fibroepithelial lesions encompass a wide spectrum of tumors ranging from an indolent fibroadenoma to potentially fatal malignant phyllodes tumor. The criteria used for their classification based on morphological assessment are often challenging to apply and there is no consensus as to what constitutes an adequate resection margin. We studied a retrospective cohort of 213 fibroepithelial lesions in 178 patients (80 fibroadenomas with unusual features and 133 phyllodes tumors: 63 benign, 41 borderline, and 29 malignant) in order to describe the spectrum of changes within each group, with special emphasis on margin evaluation...
February 14, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Benjamin F Dessauvagie, Andrew H S Lee, Katie Meehan, Anju Nijhawan, Puay Hoon Tan, Jeremy Thomas, Bibiana Tie, Darren Treanor, Seemeen Umar, Andrew M Hanby, Rebecca Millican-Slater
AIM: Fibroepithelial lesions (FELs) of the breast span a morphological continuum including lesions where distinction between cellular fibroadenoma (FA) and benign phyllodes tumour (PT) is difficult. The distinction is clinically important with FAs managed conservatively while equivocal lesions and PTs are managed with surgery. We sought to audit core biopsy diagnoses of equivocal FELs by digital pathology and to investigate whether digital point counting is useful in clarifying FEL diagnoses...
February 13, 2018: Journal of Clinical Pathology
Kangyu Wang, Qianhua Li, Ranran Shi, Dandan Yang, Wenlu Zou, Kun Mu
No abstract text is available yet for this article.
February 2018: Annals of Diagnostic Pathology
Benjamin Yongcheng Tan, Puay Hoon Tan
Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. Fibroadenomas are common benign neoplasms that may be treated conservatively. Phyllodes tumors are relatively rare lesions, and classified as benign, borderline, or malignant based on histologic evaluation of various parameters. The diagnostic interpretation of "gray-zone" fibroepithelial lesions often imposes formidable demands on a pathologist's skills...
March 2018: Surgical Pathology Clinics
Megan Kalambo, Beatriz E Adrada, Modupe M Adeyefa, Savitri Krishnamurthy, Ken Hess, Selin Carkaci, Gary J Whitman
OBJECTIVE: The purpose of this study is to evaluate the sonographic and histopathologic features distinguishing benign from borderline and malignant phyllodes tumors. MATERIALS AND METHODS: The ultrasound examinations of women with pathologically proven phyllodes tumors from 2004 to 2011 were retrospectively reviewed. The sonographic features of benign, borderline, and malignant phyllodes tumors were compared and analyzed using the American College of Radiology's BI-RADS ultrasound lexicon...
February 7, 2018: AJR. American Journal of Roentgenology
Hitoshi Ono, Ayami Sasaki, Masaru Nomura, Kazuyoshi Oomori
A 72-year-old woman noted a mass in the left breast about 5 years ago, but she did not consult a medical institution. She was taken in the ambulance and hospitalized to our department due to severe anemia and malnutrition. A computed tomography( CT)scan indicated an 18×12 cm tumor in her left breast. A fiborsarcoma protuberance was suspected based on needle core biopsy results. Simple mastectomy was performed to control hemorrhage and infection. The resected tumor weighed 2.6 kg. The pathological diagnosis was a malignant phyllodes tumor...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Laurence M Briski, Julie M Jorns
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) and its higher-grade counterpart, dedifferentiated liposarcoma (DDL), are extraordinarily rare tumors in the breast. The main differential diagnostic consideration of primary breast ALT/WDL is malignant phyllodes tumor with liposarcomatous differentiation, and the main differential diagnostic consideration of DDL in the breast is metaplastic breast carcinoma, particularly the spindle cell type, with heterologous sarcomatous differentiation...
February 2018: Archives of Pathology & Laboratory Medicine
Chin Cheng Su, Chih-Jung Chen, Shou-Jen Kuo
A 76-year-old female patient with a malignant phyllodes tumor underwent modified radical mastectomy and wide excision. Multiple nodules were observed in the operated wound area. Positron emission tomography-computed tomography (PET-CT) revealed recurrent disease in the left breast, the adjacent left third rib, the left internal mammary region and the left ilium. A novel formulation of bevacizumab (5 mg/m2, first day) in combination with liposomal doxorubicin (Lipodox, 30 mg/m2, second day) was administered for 3 cycles every 2 weeks, and subsequently wide excision was performed...
December 2017: Oncology Letters
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