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https://www.readbyqxmd.com/read/29332027/phyllodes-tumors-of-the-breast-clinicopathological-analysis-of-106-cases-from-a-single-institution
#1
Boubacar Efared
BACKGROUND: Phyllodes tumors (PT) are uncommon biphasic tumors, accounting for less than 1% of all breast primary neoplasms. They form a wide variety of tumors ranging from benign to malignant. Several histological features are used to grade PT into 3 categories: benign (grade I), borderline (grade II) and malignant (grade III) tumors. The aim of our study was to analyse histolopathological, radiological and clinical features of PT from an experience of a single center. METHODS: It was a retrospective study including 106 patients diagnosed with phyllodes tumors on surgical specimens at the department of pathology, of Hassan II university hospital (Fez, Morocco), from 2009 to 2016...
January 10, 2018: Breast Disease
https://www.readbyqxmd.com/read/29317034/case-report-metastatic-phyllodes-tumor
#2
Lorell Ruiz-Flores, Lilian O Ebuoma, Marcelo F Benveniste, Chandandeep Nagi, Tamara OrtizPerez, Ana Paula Benveniste
This report describes the clinical presentation, imaging findings, and treatment options of a case of metastatic malignant phyllodes.
February 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29315289/med12-tert-promoter-and-rbm15-mutations-in-primary-and-recurrent-phyllodes-tumours
#3
Diego A Garcia-Dios, Dina Levi, Vandna Shah, Cheryl Gillett, Michael A Simpson, Andrew Hanby, Ian Tomlinson, Elinor J Sawyer
BACKGROUND: MED12 and TERT promoter mutations have been shown to be the most common somatic mutations in phyllodes tumours (PTs). The aims of this study were to determine the frequency of these mutations in recurrent PTs, assess whether TERT promoter mutations could be helpful in distinguishing fibroadenomas (FAs) from PTs and identify novel mutations that may be driving malignant progression. METHODS: MED12 and the TERT promoter were Sanger sequenced in 75 primary PTs, 21 recurrences, 19 single FAs and 2 cases of multiple FAs with benign PTs...
January 9, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29312836/malignant-epithelial-transformation-in-phyllodes-tumor-a-population-based-case-series
#4
Ralph L Widya, Myra F Rodrigues, Pauline T Truong, Peter H Watson, Lorna M Weir, Margaret A Knowling, Elaine S Wai
Background Phyllodes tumor (PT) of the breast is an uncommon fibroepithelial neoplasm. Malignant epithelial transformation in PT is rare. This study reports clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT. Methods From an institutional database of 183 patients with newly diagnosed PT referred to a Canadian provincial cancer institution between 1999 and 2014, 11 cases of PT with concomitant in situ or invasive carcinoma were identified. Descriptive analysis was performed to document the characteristics, treatment and outcomes of this cohort...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29302481/development-of-a-surgical-algorithm-by-using-pre-operative-imaging-to-predict-mammoplasty-cosmetic-outcomes-for-large-non-malignant-tumours
#5
Geok-Hoon Lim, Ruey Pyng Ng, Lester Chee Hao Leong
Background: Use of mammoplasty for resection of large non-malignant tumours is not widely described. We aim to determine the optimal tumour to breast size ratio cut-off in this group of patients undergoing mammoplasty which could achieve satisfactory cosmetic outcomes. Methods: Patients who underwent mammoplasty from May 2014 to June 2017 for biopsy-proven large non-malignant tumours were included in the study. The demographics, tumour to breast size ratios, histological features and cosmetic outcomes of these patients were assessed...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29290198/progression-of-fibroadenoma-to-malignant-phyllodes-tumour-in-a-14-year-female
#6
Shahbaz Habib Faridi, Bushra Siddiqui, Syed Shamshad Ahmad, Mohammad Aslam
Phyllodes tumours are uncommon breast tumours which account for less than 1% of all breast neoplasms. High-grade malignant phyllodes tumour is a very rare but aggressive breast malignancy and forms approximately 15-30% of all phyllodes tumours. The transformation of a benign fibroadenoma into a malignant phyllodes tumour in a teenaged female is even rarer. We report here an interesting case of malignant phyllodes tumour in a 14-year female patient who was operated twice previously with the diagnosis of complex fibroadenoma in the same breast...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29258903/whole-exome-sequencing-demonstrates-recurrent-somatic-copy-number-alterations-and-sporadic-mutations-in-specialized-stromal-tumors-the-prostate
#7
Chin-Chen Pan, Toyonori Tsuzuki, Eiichi Morii, Hiroaki Fushimi, Paul Chih-Hsueh Chen, Jonathan I Epstein
In a previous array comparative genomic hybridization study, we detected common deletions of chromosomes 13 and 14 in prostatic stromal sarcoma and stromal tumor of uncertain malignant potential (STUMP). In this study, we performed whole exome sequencing (WES) and fluorescence in situ hybridization (FISH) to explore somatic mutations in 1 low-grade stromal sarcoma, 1 high-grade stromal sarcoma, and 12 STUMPs including 5 cases of degenerative atypia type, 1 myxoid type, 1 phyllodes type, and 5 cases of recently described round cell type...
December 16, 2017: Human Pathology
https://www.readbyqxmd.com/read/29250309/phyllodes-tumor-masquerading-as-a-fungating-breast-mass
#8
Nolan R Bruce, Jacob T Carlson, Kayla J Barnard, Ronda Henry-Tillman
Phyllodes tumor of the breast is an uncommonly encountered disease. The tumor presenting as fungating breast mass or 'ruptured' breast is an even more rare presentation of an unusual disease. This report documents the case of a 60-year-old female with delayed presentation of a large exophytic mass of the left breast. Biopsy of this lesion was non-diagnostic, so excision via left total mastectomy was performed. The final pathology was consistent with malignant phyllodes tumor. This report highlights the features of a rare breast cancer, the challenges in obtaining a definitive diagnosis, and the treatment of this disease, in an effort to provide clinicians with an example of the management of such a peculiar entity...
December 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29248888/genetics-and-genomics-of-breast-fibroadenomas
#9
REVIEW
Benjamin Nathanael Loke, Nur Diyana Md Nasir, Aye Aye Thike, Jonathan Yu Han Lee, Cheok Soon Lee, Bin Tean Teh, Puay Hoon Tan
Fibroadenomas of the breast are benign fibroepithelial tumours most frequently encountered in women of reproductive age, although they may be diagnosed at any age. The fibroadenoma comprises a proliferation of both stromal and epithelial components. The mechanisms underlying fibroadenoma pathogenesis remain incompletely understood. In the clinical setting, distinguishing cellular fibroadenomas from benign phyllodes tumours is a common diagnostic challenge due to subjective histopathological criteria and interobserver differences...
December 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29247967/early-stage-malignant-phyllodes-tumor-case-report
#10
Thao Wolbert, Emilia C N Leigh, Rahman Barry, Jack R Traylor, Mary Legenza
INTRODUCTION: Malignant phyllodes tumor of the breast is an extremely rare entity usually presenting with similar clinical features with those of benign fibroadenoma. Due to its scarcity and clinical presentation, it is quite difficult for clinicians to suspect and diagnose the disease at its early stage. There is currently no consensus regarding adjunctive radiotherapy, hormonal therapy and systemic chemotherapy recommended for malignant phyllodes tumors. PRESENTATION OF CASE: This report presents a case of early-stage malignant phyllodes tumor treated by lumpectomy only without adjunctive chemoradiation therapy, but with an excellent outcome...
December 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245318/recurrent-malignant-phyllodes-tumor-of-the-breast-a-case-report
#11
Qinqin Wang, Jing Su, Yutao Lei
RATIONALE: Phyllodes tumor is a rare fibro epithelial neoplasm of the breast. They resemble fibroadenomas clinically and can be mistakenly ignored sometimes. PATIENT CONCERNS: We report the case of a young woman with her first presentation to hospital due to a hypoglycemia and she underwent 2 excised fibroadenomas in the same breast before diagnosed of malignant phyllodes tumor. She was complaining about 2 masses presented in her right breast 4 months after mastectomy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29232600/a-retrospective-review-of-phyllodes-tumours-of-the-breast-a-single-institution-experience
#12
Vithusha Ganesh, Leah Drost, Justin Lee, Bo Angela Wan, Liying Zhang, Eileen Rakovitch, Danny Vesprini, Elzbieta Slodkowska, K Liang Zeng, Philomena Sousa, Caitlin Yee, Henry Lam, Edward Chow
BACKGROUND: Phyllodes tumours are rare and histologically diverse, posing challenges in prognosis and treatment. Due to their rarity, they have seldom been studied. PURPOSE: The purpose was to investigate clinical practices in the management of phyllodes tumours, as well as patient outcomes to contribute to the limited body of knowledge surrounding these tumours. METHODS: A retrospective review was conducted on all patients with phyllodes tumours at a single institution...
December 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29231040/differentiation-between-phyllodes-tumors-and-fibroadenomas-using-intravoxel-incoherent-motion-magnetic-resonance-imaging-comparison-with-conventional-diffusion-weighted-imaging
#13
Hiroko Kawashima, Tosiaki Miyati, Naoki Ohno, Masako Ohno, Masafumi Inokuchi, Hiroko Ikeda, Toshifumi Gabata
OBJECTIVE: To investigate whether the parameters derived from intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) could differentiate phyllodes tumors (PTs) from fibroadenomas (FAs) by comparing the apparent diffusion coefficient (ADC) values. METHODS: This retrospective study included seven FAs, 10 benign PTs (BPTs), four borderline PTs, and one malignant PT. Biexponential analyses of IVIM were performed using a 3 T MRI scanner. Quantitative IVIM parameters (pure diffusion coefficient [D], perfusion-related diffusion coefficient [D*], and fraction [f]) were calculated...
December 12, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29189868/-breast-osteosarcoma-originating-in-a-phyllodes-tumor-report-of-one-case
#14
Tereza Nieto-Coronel, Jessica Elizabeth Salazar-Campos, David Cantú de León, Raúl Díaz-Molina, Rafael Vázquez-Romo, Enrique Bargalló-Rocha
Phyllodes tumors account for less than 1% of tumors of the mammary gland, have both epithelial and stromal components and are classified as benign, borderline and malignant. The malignant tumors are highly heterogeneous: they can differentiate to liposarcomas, fibrosarcomas, rhabdomyosarcomas, chondrosarcomas or osteosarcomas. The differentiation to osteosarcoma is extremely rare, constitutes 1.3% of cases and is very aggressive. The standard treatment of these tumors is surgical. The role of radiotherapy and chemotherapy is not clear...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29169272/a-case-of-benign-phyllodes-tumor-in-a-transgender-woman-receiving-cross-sex-hormones
#15
Stephanie M Richards, Elyse D Pine-Twaddell, Olga B Ioffe, Emily C Bellavance
Phyllodes tumor is a relatively uncommon fibroepithelial neoplasm of the breast characterized by proliferation of both stromal and epithelial elements. Benign phyllodes tumors are distinguished from fibroadenomas by their prominent leaf-like architecture and exaggerated intracanalicular stromal growth pattern. Typically, these lesions affect older natal females; however, we present what we believe is the first reported case of benign phyllodes tumor in a hormonally treated transgender woman.
November 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29158931/atypical-distant-metastasis-of-breast-malignant-phyllodes-tumors-a-case-report-and-literature-review
#16
Tiphaine de Foucher, Hélène Roussel, Mikael Hivelin, Léa Rossi, Caroline Cornou, Anne-Sophie Bats, Myriam Deloménie, Fabrice Lécuru, Charlotte Ngô
Malignant phyllodes tumors (MPT) are rare breast neoplasms. Preoperative diagnosis is often challenging due to the unspecific clinical, radiological, and histological characteristics of the tumor. Dissemination pathways are local with chest wall invasion, regional with lymph nodes metastasis, and distant, hematogenous, mostly to the lungs, bones, and brain. Distant metastasis (DM) can be synchronous or appear months to years after the diagnosis and initial management. The current report describes the case of a 57-year-old woman presenting with a giant/neglected MPT of the breast, with no DM at initial staging, treated by radical modified mastectomy...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29151311/how-to-manage-pseudoangiomatous-stromal-hyperplasia-our-clinical-experience
#17
Emine Kurt, Sevim Turanlı, Fatma Markoç, Uğur Berberoğlu
Background/aim: Pseudoangiomatous stromal hyperplasia (PASH) is a rare and benign mesenchymal proliferative breast lesion. Our aim is to review the clinical and radiological features of PASH and define a standard approach for its diagnosis and management. Materials and methods: Clinical records of 35 consecutive patients with PASH were retrospectively reviewed between 2009 and 2015. Patients with clinically or radiologically detected mass and patients who underwent biopsy for other indications and were diagnosed incidentally were included in the study...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29149740/skin-reducing-mastectomy-and-direct-to-implant-reconstruction-in-giant-phyllodes-tumour-of-breast-case-report
#18
Francesco Ciancio, Alessandro Innocenti, Luigi Cagiano, Aurelio Portincasa, Domenico Parisi
BACKGROUND: The phyllodes tumour of the breast comprises about 0.5% of all neoplasms of the breast. CASE REPORT: we present the case of a female patient (55 years old) suffering from giant phyllodes tumour (>10cm) of the left breast, who underwent Skin Reducing Mastectomy (SRM) and reconstruction with silicone breast implant (Bostwick Technique). DISCUSSION AND CONCLUSION: In selected patients with large sized breasts (C-D cup) and poor surface area of skin involved, a valid technique in the treatment of this pathology is the Skin-Reducing Mastectomy and immediate reconstruction with implants (DTI=direct to implant)...
November 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29146885/mammary-phyllodes-tumour-a-15-year-multicentre-clinical-review
#19
Michael Co, Clement Chen, Julia Y Tsang, Gary Tse, Ava Kwong
AIMS: Phyllodes tumour (PT) is an uncommon fibroepithelial tumour of the breast. It has a spectrum of aggressiveness in biological behaviour with chance of local recurrence and, occasionally, metastasis. METHODS: A 15-year retrospective review from a multicentre database in Hong Kong was performed. RESULTS: Clinical and pathological records of 465 patients with 469 PTs between 1998 and 2014 were reviewed. Median age of occurrence was 44 years (range 12-86 years)...
November 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29145261/phyllodes-tumors-of-the-breast-in-2-sisters-case-report-and-review-of-literature
#20
Yichao Wang, Jingqiang Zhu, Junhe Gou, JunJie Xiong, Xiaoqin Yang
RATIONALE: Phyllodes tumors (PT) of the breast are rare neoplasm originating from fibroepithelial component. To our knowledge, our report is the first reported case of PT in 2 sisters. PATIENT CONCERNS: We presented 2 cases of PT of the breast involving in 2 sisters. On physical examination of the younger sister, a firm mass measuring approximately 3 cm in diameter was identified in upper inner quadrant of the right breast. Physical examination of the elder sister revealed a 3 cm lump in upper outer quadrant of the left breast...
November 2017: Medicine (Baltimore)
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