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MST1 AND Fortilin

Abhijnan Chattopadhyay, Decha Pinkaew, Hung Q Doan, Reed B Jacob, Sunil K Verma, Hana Friedman, Alan C Peterson, Muge N Kuyumcu-Martinez, Owen M McDougal, Ken Fujise
Fortilin, a pro-survival molecule, inhibits p53-induced apoptosis by binding to the sequence-specific DNA-binding domain of the tumor suppressor protein and preventing it from transcriptionally activating Bax. Intriguingly, fortilin protects cells against ROS-induced cell death, independent of p53. The signaling pathway through which fortilin protects cells against ROS-induced cell death, however, is unknown. Here we report that fortilin physically interacts with the antioxidant enzyme peroxiredoxin-1 (PRX1), protects it from proteasome-mediated degradation, and keeps it enzymatically active by blocking its deactivating phosphorylation by Mst1, a serine/threonine kinase...
January 4, 2016: Scientific Reports
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