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https://www.readbyqxmd.com/read/28431219/genetic-analysis-of-%C3%AE-synuclein-3-untranslated-region-and-its-corresponding-micrornas-in-relation-to-parkinson-s-compared-to-dementia-with-lewy-bodies
#1
Lidia Tagliafierro, Omolara-Chinue Glenn, Madison E Zamora, Thomas G Beach, Randy L Woltjer, Michael W Lutz, Ornit Chiba-Falek
INTRODUCTION: The α-synuclein (SNCA) gene has been implicated in the etiology of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). METHODS: A computational analysis of SNCA 3' untranslated region to identify potential microRNA (miRNA) binding sites and quantitative real-time PCR to determine their expression in isogenic induced pluripotent stem cell-derived dopaminergic and cholinergic neurons as a model of PD and DLB, respectively, were performed. In addition, we performed a deep sequencing analysis of the SNCA 3' untranslated region of autopsy-confirmed cases of PD, DLB, and normal controls, followed by genetic association analysis of the identified variants...
April 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28430289/evidence-from-spatial-pattern-analysis-for-the-anatomical-spread-of-%C3%AE-synuclein-pathology-in-parkinson-s-disease-dementia
#2
Richard A Armstrong
<i>The objective of this study was to determine whether there is evidence from quantitative morphometry and spatial pattern analysis to support the hypothesis of anatomical spread of -synuclein in Parkinson's disease dementia (PDD). Hence, clustering of -synuclein-immunoreactive Lewy bodies (LB), Lewy neurites (LN), and Lewy grains (LG) was studied in -synuclein-immunolabeled sections of cortical and limbic regions in 12 cases of PDD. The data suggested that: (1) LB, LN, and LG occurred in clusters which in 63% of regions were regularly distributed parallel to the tissue boundary, (2) in approximately 30% of cortical regions, the estimated cluster size of LB, LN, and LG was within the size range of cellular columns associated with the cortico-cortical pathways, (3) regularly distributed clusters were present in anatomically connected regions, and (4) the clustering pattern was similar to that of prion protein (PrPsc) deposits in Creutzfeldt-Jacob disease (CJD)...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28429825/validation-of-the-mds-research-criteria-for-prodromal-parkinson-s-disease-longitudinal-assessment-in-a-rem-sleep-behavior-disorder-rbd-cohort
#3
Seyed-Mohammad Fereshtehnejad, Jacques Y Montplaisir, Amelie Pelletier, Jean-François Gagnon, Daniela Berg, Ronald B Postuma
BACKGROUND: Recently, the International Parkinson and Movement Disorder Society introduced the prodromal criteria for PD. Objectives Our study aimed to examine diagnostic accuracy of the criteria as well as the independence of prodromal markers to predict conversion to PD or dementia with Lewy bodies. METHODS: This prospective cohort study was performed on 121 individuals with rapid eye movement sleep behavior disorder who were followed annually for 1 to 12 years...
April 21, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28429355/lewy-pathological-study-on-%C3%AE-synuclein-in-gastrointestinal-tissues-of-prodromal-parkinson-s-disease
#4
Q-B Lu, Z-F Zhu, H-P Zhang, W-F Luo
OBJECTIVE: In the gastrointestinal neural system, the emergence of Lewy Body (LB) is usually earlier than the clinical diagnosis of Parkinson (PD) motor symptoms. Therefore, this study is aimed to explore whether the LB in the gastrointestinal tract of prodromal PD patients. PATIENTS AND METHODS: 98 paraffin embedded tissue specimens from 57 PD patients were collected in the Second Affiliated Hospital of Soochow University archives, as well as 98 tissue specimens of 90 non-PD patients undergone surgical resection...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429209/analysis-of-gut-microbiota-in-patients-with-parkinson-s-disease
#5
V A Petrov, I V Saltykova, I A Zhukova, V M Alifirova, N G Zhukova, Yu B Dorofeeva, A V Tyakht, B A Kovarsky, D G Alekseev, E S Kostryukova, Yu S Mironova, O P Izhboldina, M A Nikitina, T V Perevozchikova, E A Fait, V V Babenko, M T Vakhitova, V M Govorun, A E Sazonov
Gut microbiota of patients with Parkinson's disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson's diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans...
April 20, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28425185/the-influence-of-hippocampal-atrophy-on-the-cognitive-phenotype-of-dementia-with-lewy-bodies
#6
Greg J Elder, Karen Mactier, Sean J Colloby, Rosie Watson, Andrew M Blamire, John T O'Brien, John-Paul Taylor
OBJECTIVE: The level of hippocampal atrophy in dementia with Lewy bodies (DLB) is typically less than that observed in Alzheimer's disease (AD). However, it is not known how the cognitive phenotype of DLB is influenced by hippocampal atrophy or the atrophy of adjacent medial temporal lobe structures. METHODS: Dementia with Lewy bodies (n = 65), AD (n = 76) and control (n = 63) participants underwent 3T magnetic resonance imaging and cognitive Cambridge Cognitive Examination and Mini-Mental State Examination (CAMCOG and MMSE) assessments...
April 20, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28424166/applying-fluid-biomarkers-to-alzheimer-s-disease
#7
Henrik Zetterberg
Alzheimer's disease (AD) is a common neurodegenerative disease that starts with a clinically silent phase of a decade or more during which brain pathologies accumulate predominantly in the medial temporal lobe but also elsewhere in the brain. Network dysfunction and clinical symptoms typically appear when senile plaque (amyloid β) and neurofibrillary tangle (tau) pathologies meet in the brain parenchyma, producing synapse and neuronal loss. For plaque and tangle pathologies, reliable fluid biomarkers have been developed...
April 19, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28424054/an-unusual-delusion-of-duplication-in-a-patient-affected-by-dementia-with-lewy-bodies
#8
Paolo Solla, Gioia Mura, Antonino Cannas, Gianluca Floris, Davide Fonti, Gianni Orofino, Mauro Giovanni Carta, Francesco Marrosu
BACKGROUND: Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the most frequent disturbance, characterized by the recurrent and transient belief that a familiar person, often a close family member or caregiver, has been replaced by an identical-looking imposter. However, other delusional conditions near to misidentification syndromes can occur in DLB patients and may represent a major psychiatric disorder, although rarely studied systematically...
April 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28422371/effects-of-m1-and-m4-activation-on-excitatory-synaptic-transmission-in-ca1
#9
Catherine Thorn, Michael Popiolek, Eda Stark, Jeremy Edgerton
Hippocampal networks are particularly susceptible to dysfunction in many neurodegenerative diseases and neuropsychiatric disorders including Alzheimer's disease, Lewy body dementia, and schizophrenia. CA1, a major output region of the hippocampus, receives glutamatergic input from both hippocampal CA3 and entorhinal cortex, via the Schaffer collateral (SC) and temporoammonic (TA) pathways, respectively. SC and TA inputs to CA1 are thought to be differentially involved in the retrieval of previously stored memories versus the encoding of novel information, and switching between these two crucial hippocampal functions is thought to critically depend on acetylcholine (ACh) acting at muscarinic receptors...
April 19, 2017: Hippocampus
https://www.readbyqxmd.com/read/28420550/effect-of-a-moderate-caffeine-dose-on-endurance-cycle-performance-and-thermoregulation-during-prolonged-exercise-in-the-heat
#10
Ross E Beaumont, Lewis J James
OBJECTIVES: This study investigated the influence of a moderate caffeine dose on endurance cycle performance and thermoregulation during prolonged exercise in high ambient temperature. DESIGN: Double-blind cross-over study. METHODS: Eight healthy, recreationally active males (mean±SD; age: 22±1 years; body mass: 71.1±8.5kg; VO2peak: 55.9±5.8mLkg(-1)min(-1); Wmax: 318±37W) completed one VO2peak test, one familiarisation trial and two experimental trials...
March 31, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28419968/current-insights-into-pathogenesis-of-parkinson-s-disease-approach-to-mevalonate-pathway-and-protective-role-of-statins
#11
REVIEW
Seyed Soheil Saeedi Saravi, Seyed Sobhan Saeedi Saravi, Katayoun Khoshbin, Ahmad Reza Dehpour
Although Parkinson's disease (PD) is considered as the second most common life threatening age-related neurodegenerative disorder, but the underlying mechanisms for pathogenesis of PD are remained to be fully found. However, a complex relationship between genetic and environmental predisposing factors are involved in progression of PD. Dopaminergic neuronal cell death caused by mutations and accumulation of α-synuclein in Lewy bodies and neurites was suggested as the main strategy for PD, but current studies have paid attention to the role of mevalonate pathway in incidence of neurodegenerative diseases including PD...
April 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28419945/interaction-of-%C3%AE-synuclein-with-rhus-typhina-tannin-implication-for-parkinson-s-disease
#12
Szymon Sekowski, Maksim Ionov, Nodira Abdulladjanova, Rustam Makhmudov, Saidmukhtar Mavlyanov, Katarzyna Milowska, Maria Bryszewska, Maria Zamaraeva
The etiology of Parkinson's disease (PD) relates to α-synuclein, a small protein with the ability to aggregate and form Lewy bodies. One of its prevention strategies is inhibition of α-synuclein oligomerization. We have investigated the interaction of α-synuclein and human serum albumin with 3,6-bis-О-di-О-galloyl-1,2,4-tri-О-galloyl-β-d-glucose (a tannin isolated from the plant Rhus typhina). Using fluorescence spectroscopy method we found that this tannin interacts strongly with α-synuclein forming complexes...
April 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28418810/relationship-of-trochlear-morphology-and-patellofemoral-joint-alignment-to-superolateral-hoffa-fat-pad-edema-on-mr-images-in-individuals-with-or-at-risk-for-osteoarthritis-of-the-knee-the-most-study
#13
Rafael Widjajahakim, Michael Roux, Mohamed Jarraya, Frank W Roemer, Tuhina Neogi, John A Lynch, Cora E Lewis, James C Torner, David T Felson, Ali Guermazi, Joshua J Stefanik
Purpose To determine the relationship of patellofemoral joint alignment and trochlear morphology to superolateral Hoffa fat pad (SHFP) edema on magnetic resonance (MR) images in older adults with or at risk for osteoarthritis of the knee. Materials and Methods Institutional review board approval and written informed consent were obtained from all subjects. The Multicenter Osteoarthritis Study is a prospective cohort study of older adults with or at risk for osteoarthritis of the knee. Subjects were recruited from Birmingham, Alabama, and Iowa City, Iowa...
April 17, 2017: Radiology
https://www.readbyqxmd.com/read/28414651/historical-landmarks-in-dementia-with-lewy-bodies
#14
Christoph Mueller, Clive Ballard, Anne Corbett, Dag Aarsland
No abstract text is available yet for this article.
May 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28412346/superoxide-is-the-critical-driver-of-dopal-autoxidation-lysyl-adduct-formation-and-crosslinking-of-%C3%AE-synuclein
#15
Jon W Werner-Allen, Rodney L Levine, Ad Bax
Parkinson's disease has long been associated with redox imbalance and oxidative stress in dopaminergic neurons. The catecholaldehyde hypothesis proposes that 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate product of dopamine catabolism, is a central nexus in a network of pathways leading to disease-state neurodegeneration, owing to its toxicity and potent ability to oligomerize α-synuclein, the main component of protein aggregates in Lewy bodies. In this work we examine the connection between reactive oxygen species and DOPAL autoxidation...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28411117/in-vitro-%C3%AE-synuclein-neurotoxicity-and-spreading-among-neurons-and-astrocytes-using-lewy-body-extracts-from-parkinson-disease-brains
#16
Fabio Cavaliere, Loic Cerf, Benjamin Dehay, Paula Ramos-Gonzalez, Francesca De Giorgi, Mathieu Bourdenx, Alban Bessede, Jose A Obeso, Carlos Matute, François Ichas, Erwan Bezard
Synucleinopathies are a group of diseases characterized by the presence of intracellular protein aggregates containing α-synuclein (α-syn). While α-syn aggregates have been shown to induce multimodal cellular dysfunctions, uptake and transport mechanisms remain unclear. Using high-content imaging on cortical neurons and astrocytes, we here define the kinetics of neuronal and astrocytic abnormalities induced by human-derived α-syn aggregates grounding the use of such system to identify and test putative therapeutic compounds...
April 11, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28410662/lewy-body-disorders
#17
REVIEW
Douglas Galasko
Dementia syndromes associated with Lewy bodies are subdivided into dementia with Lewy bodies (DLB), an underdiagnosed cause of dementia in the elderly, and Parkinson disease with dementia (PDD), cognitive impairment appearing in people diagnosed with Parkinson disease. Their neuropathologic substrates are the widespread distribution of aggregates of the protein α-synuclein in neurons in cortical brain regions, accompanied by variable Alzheimer pathology. Clinical features of DLB and PDD include distinctive changes in cognition, behavior, movement, sleep, and autonomic function...
May 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28409032/distinct-pattern-of-microgliosis-in-the-olfactory-bulb-of-neurodegenerative-proteinopathies
#18
Zacharias Kohl, Johannes C M Schlachetzki, Judith Feldewerth, Philipp Hornauer, Martina Münch, Anthony Adame, Markus J Riemenschneider, Jürgen Winkler, Eliezer Masliah
The olfactory bulb (OB) shows early neuropathological hallmarks in numerous neurodegenerative diseases, for example, in Alzheimer's disease (AD) and Parkinson's disease (PD). The glomerular and granular cell layer of the OB is characterized by preserved cellular plasticity in the adult brain. In turn, alterations of this cellular plasticity are related to neuroinflammation such as microglia activation, implicated in the pathogenesis of AD and PD, as well as frontotemporal lobe degeneration (FTLD). To determine microglia proliferation and activation we analyzed ionized calcium binding adaptor molecule 1 (Iba1) expressing microglia in the glomerular and granular cell layer, and the olfactory tract of the OB from patients with AD, PD dementia/dementia with Lewy bodies (PDD/DLB), and FTLD compared to age-matched controls...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28407040/experiences-of-discrimination-and-incident-type-2-diabetes-mellitus-the-multi-ethnic-study-of-atherosclerosis-mesa
#19
Kara M Whitaker, Susan A Everson-Rose, James S Pankow, Carlos J Rodriguez, Tené T Lewis, Kiarri N Kershaw, Ana V Diez Roux, Pamela L Lutsey
Experiences of discrimination are associated with increased risk of adverse health outcomes; however, it is unknown whether discrimination is related to incident type 2 diabetes mellitus (diabetes). We investigated the associations of major experiences of discrimination (unfair treatment in 6 situations) and everyday discrimination (frequency of day-to-day experiences of unfair treatment) with incident diabetes among 5,310 participants from the Multi-Ethnic Study of Atherosclerosis, enrolled in 2000-2002. Using Cox proportional hazards models, we estimated hazard ratios and confidence intervals, adjusting for demographic factors, depressive symptoms, stress, smoking, alcohol, physical activity, diet, waist circumference, and body mass index...
April 12, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28406488/making-genomic-medicine-evidence-based-and-patient-centered-a-structured-review-and-landscape-analysis-of-comparative-effectiveness-research
#20
REVIEW
Kathryn A Phillips, Patricia A Deverka, Harold C Sox, Muin J Khoury, Lewis G Sandy, Geoffrey S Ginsburg, Sean R Tunis, Lori A Orlando, Michael P Douglas
Comparative effectiveness research (CER) in genomic medicine (GM) measures the clinical utility of using genomic information to guide clinical care in comparison to appropriate alternatives. We summarized findings of high-quality systematic reviews that compared the analytic and clinical validity and clinical utility of GM tests. We focused on clinical utility findings to summarize CER-derived evidence about GM and identify evidence gaps and future research needs. We abstracted key elements of study design, GM interventions, results, and study quality ratings from 21 systematic reviews published in 2010 through 2015...
April 13, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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