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https://www.readbyqxmd.com/read/29456869/cognitive-fluctuations-in-parkinson-s-disease-dementia-blood-pressure-lability-as-an-underlying-mechanism
#1
David E Riley, Alberto J Espay
Background: Cognitive fluctuations refer to alterations in cognition, attention, or arousal occurring over minutes to hours, most commonly in patients with dementias associated with advanced Lewy body pathology. Their pathophysiologic underpinning remains undetermined. Case presentation: We documented serial blood pressure (BP) measurements in an 86-year-old man with Parkinson's disease dementia experiencing cognitive fluctuations during an office visit. This patient's associated dysautonomia included labile BP with orthostatic hypotension and nocturnal hypertension...
2018: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/29454305/psychotropic-and-anti-dementia-treatment-in-elderly-persons-with-clinical-signs-of-dementia-with-lewy-bodies-a-cross-sectional-study-in-40-nursing-homes-in-sweden
#2
Iris Zahirovic, Gustav Torisson, Carina Wattmo, Elisabet Londos
BACKGROUND: Elderly persons with a dementia diagnosis often suffer from different neuropsychiatric symptoms (NPS) such as delusions, hallucinations, depression, anxiety, irritability and agitation. Currently, the medical treatment for NPS consists mostly of psychotropic medication such as hypnotics/sedatives, anxiolytics and antipsychotics. In elderly persons with dementia, usage of antipsychotics is less appropriate because of the risk of side effects such as parkinsonism, rapid cognitive decline, cerebrovascular events and finally mortality...
February 17, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29453242/single-subject-spm-fdg-pet-patterns-predict-risk-of-dementia-progression-in-parkinson-disease
#3
Andrea Pilotto, Enrico Premi, Silvia Paola Caminiti, Luca Presotto, Rosanna Turrone, Antonella Alberici, Barbara Paghera, Barbara Borroni, Alessandro Padovani, Daniela Perani
OBJECTIVE: To evaluate the statistical parametric mapping (SPM) procedure for fluorodeoxyglucose (FDG)-PET imaging as a possible single-subject marker of progression to dementia in Parkinson disease (PD). METHODS: Fifty-four consecutive patients with PD without dementia (age at onset of 59.9 ± 10.1 years, disease duration of 5.3 ± 3.4 years) entered the study. The patients underwent an extensive motor and cognitive assessment and a single-subject FDG-PET SPM evaluation at baseline...
February 16, 2018: Neurology
https://www.readbyqxmd.com/read/29452999/chylothorax-as-a-risk-factor-for-thrombosis-in-adults-a-proof-of-concept-study
#4
Sumedh S Hoskote, Hemang Yadav, Prashant Jagtap, Dennis A Wigle, Craig E Daniels
BACKGROUND: Postoperative chylothorax in children is associated with an increased risk of vascular thrombosis, hypothesized to be from loss of antithrombin into chylous fluid resulting in a hypercoagulable state. In adults, an increased thrombotic risk with chylothorax has not been described. Adults undergoing Ivor-Lewis esophagogastrectomy have two strong thrombotic risk factors-active malignancy and postoperative state-allowing for relative homogeneity in baseline thrombotic risk; therefore, we studied the association of chylothorax with thrombosis in this population...
February 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29451381/from-a-highly-disordered-to-a-metastable-state-uncovering-insights-of-%C3%AE-synuclein
#5
Yoann Cote, Patrice Delarue, Harold Abraham Scheraga, Patrick Senet, Gia G Maisuradze
α-synuclein (αS) is a major constituent of Lewy bodies, the insoluble aggregates that are the hallmark of one of the most prevalent neurodegenerative disorders - Parkinson's disease (PD). The vast majority of experiments in vitro and in vivo provide extensive evidence that a disordered monomeric form is the predominant state of αS in water solution, and it undergoes a large-scale disorder-to-helix transition upon binding to vesicles of different types. Recently, another form, tetrameric, of αS with a stable helical structure was identified experimentally...
February 16, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29448953/clinical-prevalence-of-lewy-body-dementia
#6
Joseph P M Kane, Ajenthan Surendranathan, Allison Bentley, Sally A H Barker, John-Paul Taylor, Alan J Thomas, Louise M Allan, Richard J McNally, Peter W James, Ian G McKeith, David J Burn, John T O'Brien
BACKGROUND: The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson's disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studies vary greatly. Small sample sizes and methodological factors in these studies limit generalisability to clinical practice. METHODS: We investigated prevalence in a case series across nine secondary care services over an 18-month period, to determine how commonly DLB and PDD cases are diagnosed and reviewed within two regions of the UK...
February 15, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29444097/the-effects-of-intensified-training-on-resting-metabolic-rate-rmr-body-composition-and-performance-in-trained-cyclists
#7
Amy L Woods, Anthony J Rice, Laura A Garvican-Lewis, Alice M Wallett, Bronwen Lundy, Margot A Rogers, Marijke Welvaert, Shona Halson, Andrew McKune, Kevin G Thompson
BACKGROUND: Recent research has demonstrated decreases in resting metabolic rate (RMR), body composition and performance following a period of intensified training in elite athletes, however the underlying mechanisms of change remain unclear. Therefore, the aim of the present study was to investigate how an intensified training period, designed to elicit overreaching, affects RMR, body composition, and performance in trained endurance athletes, and to elucidate underlying mechanisms. METHOD: Thirteen (n = 13) trained male cyclists completed a six-week training program consisting of a "Baseline" week (100% of regular training load), a "Build" week (~120% of Baseline load), two "Loading" weeks (~140, 150% of Baseline load, respectively) and two "Recovery" weeks (~80% of Baseline load)...
2018: PloS One
https://www.readbyqxmd.com/read/29442234/microstructural-changes-in-patients-with-parkinson-disease-and-rem-sleep-behavior-disorder-depressive-symptoms-versus-non-depressed
#8
Farzaneh Ghazi Sherbaf, Farzaneh Rahmani, Sommayeh Mohammadi Jooyandeh, Mohammad Hadi Aarabi
Search for Parkinson's disease (PD) progression biomarkers has led to the identification of both motor and non-motor symptoms relevant of prodromal PD that could be eye-opening to the spreading underlying Lewy body pathogenesis. One most robust predictor of PD is the REM sleep behavior disorder (RBD), and one most common early non-motor symptom of PD is depression. With RBD, frequently coexisting with clinical depression and both predicting dopamine transmission dysfunction, we aimed to survey structural associates of depressive symptoms in early PD patients with comorbid RBD...
February 13, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29439335/abnormalities-of-resting-state-cortical-eeg-rhythms-in-subjects-with-mild-cognitive-impairment-due-to-alzheimer-s-and-lewy-body-diseases
#9
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Laura Vacca, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Heinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B Frisoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, John Paul Taylor, Maria Francesca De Pandis, Laura Bonanni
The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29439333/risk-of-conversion-to-dementia-in-a-mild-behavioral-impairment-group-compared-to-a-psychiatric-group-and-to-a-mild-cognitive-impairment-group
#10
Fernando E Taragano, Ricardo F Allegri, Silvina L Heisecke, María I Martelli, Mónica L Feldman, Viviana Sánchez, Virginia A García, Graciela Tufro, Diego M Castro, Patricio Perez Leguizamón, Verónica Guelar, Eva Ruotolo, Cecilia Zegarra, Carol Dillon
BACKGROUND: There is insufficient available information on behavioral changes in the absence of cognitive impairment as factors increasing the risk of conversion to dementia. OBJECTIVE: To observe and analyze patients with mild behavioral impairment (MBI), mild cognitive impairment (MCI), and a psychiatry group (PG) to compare the risk of progression to dementia. METHODS: From 677 initially assessed ≥60-year-old patients, a series of 348 patients was studied for a five-year period until censoring or conversion to dementia: 96 with MBI, 87 with MCI, and 165 with general psychiatry disorders, including 4 subgroups: Anxiety, Depression, Psychosis and Others...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29439326/is-there-a-characteristic-clinical-profile-for-patients-with-dementia-and-sundown-syndrome
#11
David Angulo Sevilla, María Teresa Carreras Rodríguez, Patricia Heredia Rodríguez, Marisa Fernández Sánchez, José Aurelio Vivancos Mora, Ana Beatriz Gago-Veiga
BACKGROUND: Sundown syndrome (SS) is the onset or worsening of behavioral symptoms in the evening in patients with dementia. OBJECTIVE: To identify the differential clinical profile of patients with dementia who present SS. METHODS: A cross-sectional, case-control observational study was conducted by retrospectively reviewing the medical records of patients with dementia in a specialized Memory Unit. We compared the characteristics of patients with and without SS, including sociodemographic variables, etiology, and severity of the dementia, behavioral symptoms, sleep disorders (considering insomnia and hypersomnia), other diseases and treatments employed...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29438029/author-response-diagnosis-and-management-of-dementia-with-lewy-bodies-fourth-consensus-report-of-the-dlb-consortium
#12
Ian G McKeith
No abstract text is available yet for this article.
February 6, 2018: Neurology
https://www.readbyqxmd.com/read/29438028/reader-response-diagnosis-and-management-of-dementia-with-lewy-bodies-fourth-consensus-report-of-the-dlb-consortium
#13
Gang Wang, Hai-Lun Cui, Yue Huang
No abstract text is available yet for this article.
February 6, 2018: Neurology
https://www.readbyqxmd.com/read/29438027/reader-response-diagnosis-and-management-of-dementia-with-lewy-bodies-fourth-consensus-report-of-the-dlb-consortium
#14
Jacy B Parmera, Sonia Brucki, Ricardo Nitrini
No abstract text is available yet for this article.
February 6, 2018: Neurology
https://www.readbyqxmd.com/read/29438026/reader-response-diagnosis-and-management-of-dementia-with-lewy-bodies-fourth-consensus-report-of-the-dlb-consortium
#15
Toshiki Uchihara, Shuta Toru
No abstract text is available yet for this article.
February 6, 2018: Neurology
https://www.readbyqxmd.com/read/29438025/reader-response-diagnosis-and-management-of-dementia-with-lewy-bodies-fourth-consensus-report-of-the-dlb-consortium
#16
Kazuo Abe
No abstract text is available yet for this article.
February 6, 2018: Neurology
https://www.readbyqxmd.com/read/29438024/editors-note-diagnosis-and-management-of-dementia-with-lewy-bodies-fourth-consensus-report-of-the-dlb-consortium
#17
Megan Alcauskas, Steven Galetta
No abstract text is available yet for this article.
February 6, 2018: Neurology
https://www.readbyqxmd.com/read/29434298/loss-of-autophagy-in-dopaminergic-neurons-causes-lewy-pathology-and-motor-dysfunction-in-aged-mice
#18
Shigeto Sato, Toshiki Uchihara, Takahiro Fukuda, Sachiko Noda, Hiromi Kondo, Shinji Saiki, Masaaki Komatsu, Yasuo Uchiyama, Keiji Tanaka, Nobutaka Hattori
Inactivation of constitutive autophagy results in the formation of cytoplasmic inclusions in neurons, but the relationship between impaired autophagy and Lewy bodies (LBs) as well as the in vivo process of formation remains unknown. Synuclein, a component of LBs, is the defining characteristic of Parkinson's disease (PD). Here, we characterize dopamine (DA) neuron-specific autophagy-deficient mice and provide in vivo evidence for LB formation. Synuclein deposition is preceded by p62 and resulted in the formation of inclusions containing synuclein and p62...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433982/bimolecular-fluorescence-complementation-of-alpha-synuclein-demonstrates-its-oligomerization-with-dopaminergic-phenotype-in-mice
#19
Waijiao Cai, Danielle Feng, Michael A Schwarzschild, Pamela J McLean, Xiqun Chen
Alpha-synuclein (αSyn) is encoded by the first causal gene identified in Parkinson's disease (PD) and is the main component of Lewy bodies, a pathological hallmark of PD. aSyn-based animal models have contributed to our understanding of PD pathophysiology and to the development of therapeutics. Overexpression of human wildtype αSyn by viral vectors in rodents recapitulates the loss of dopaminergic neurons from the substantia nigra, another defining pathological feature of the disease. The development of a rat model exhibiting bimolecular fluorescence complementation (BiFC) of αSyn by recombinant adeno-associated virus facilitates detection of the toxic αSyn oligomers species...
January 31, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29432756/region-and-cell-specific-aneuploidy-in-brain-aging-and-neurodegeneration
#20
REVIEW
C E Shepherd, Y Yang, G M Halliday
Variations in genomic DNA content, or aneuploidy, are a well-recognized feature of normal human brain development. Whether changes in the levels of aneuploidy are a factor in Alzheimer's disease (AD) is less clear, as the data reported to date vary substantially in the levels of aneuploidy detected (0.7-11.5%), possibly due to methodological limitations, but also influenced by individual, regional and cellular heterogeneity as well as variations in cell subtypes. These issues have not been adequately addressed to date...
February 9, 2018: Neuroscience
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