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Melanoma surgery

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https://www.readbyqxmd.com/read/28099365/melanoma-during-pregnancy-a-report-of-60-pregnancies-complicated-by-melanoma
#1
Jorine de Haan, Christianne A Lok, Christianne J de Groot, Marianne B Crijns, Kristel Van Calsteren, Karina Dahl Steffensen, Michael J Halaska, Sevilay Altintas, Ingrid A Boere, Robert Fruscio, Wojciech Kolawa, Petronella O Witteveen, Frédéric Amant
The management of melanoma during pregnancy is challenging as maternal benefits and fetal risks need to be balanced. Here, we present an overview of the incidence, the demographic and clinical characteristics and the treatment modalities used. After analysis of obstetric, fetal and maternal outcome, recommendations for clinical practice are provided. From the 'International Network on Cancer, Infertility and Pregnancy' database, pregnant patients with melanoma were identified and analysed. Sixty pregnancies were eligible for analysis...
January 17, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28091975/update-on-advanced-melanoma-treatments-small-molecule-targeted-therapy-immunotherapy-and-future-combination-therapies
#2
Andrew Kwong, Martina Sanlorenzo, Klemens Rappersberger, Igor Vujic
Early stage melanomas can achieve remarkable outcomes with surgery alone, but stage IV metastatic melanoma requires significant intervention and has poor outcomes. Here we present evidence on the latest advances in melanoma treatment, discuss the scientific concepts behind new therapies, and analyze the potential of future treatment combinations.
January 13, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28087048/-characteristics-and-risk-factors-for-recurrence-of-cutaneous-squamous-cell-carcinoma-with-conventional-surgery-and-surgery-with-delayed-intraoperative-margin-assessment
#3
Judith Domínguez-Cherit, Georgina Rodríguez-Gutiérrez, Verónica Narváez Rosales, Sonia Toussaint Caire, Verónica Fonte Avalos
BACKGROUND: Non-melanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma (SCC). Basal cell carcinoma is the most common and least aggressive but in a low percentage of cases, despite appropriate wide surgical margins, it can be aggressive, producing local invasion, recurrences and distance metastasis. SCC has a more aggressive behaviour invading first the skin, the lymph nodes and less frequently produces distance metastasis OBJECTIVE: To identify the characteristics of recurrent SCC and frequency of new SCC after conventional surgical and primary closure or closure delayed until a histological reporting of tumour-free surgical margins, in order to achieve a better surgical option, in our Mexican population...
January 10, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28074906/antiproliferative-effects-of-1%C3%AE-oh-vitd3-in-malignant-melanoma-potential-therapeutic-implications
#4
Lucia Spath, Alessandra Ulivieri, Luca Lavra, Laura Fidanza, Marta Carlesimo, Maria Giubettini, Alessandra Narcisi, Emidio Luciani, Barbara Bucci, Daniela Pisani, Salvatore Sciacchitano, Armando Bartolazzi
Early detection and surgery represent the mainstay of treatment for superficial melanoma, but for high risk lesions (Breslow's thickness >0.75 mm) an effective adjuvant therapy is lacking. Vitamin D insufficiency plays a relevant role in cancer biology. The biological effects of 1α hydroxycholecalciferol on experimental melanoma models were investigated. 105 melanoma patients were checked for 25-hydroxycholecalciferol (circulating vitamin D) serum levels. Human derived melanoma cell lines and in vivo xenografts were used for studying 1α-hydroxycholecalciferol-mediated biological effects on cell proliferation and tumor growth...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073583/clinical-factors-associated-with-subclinical-spread-of-in-situ-melanoma
#5
Thuzar M Shin, Jeremy R Etzkorn, Joseph F Sobanko, David J Margolis, Joel M Gelfand, Emily Y Chu, Rosalie Elenitsas, Waqas R Shaikh, Christopher J Miller
BACKGROUND: Subclinical spread of in situ melanoma occurs at a wide frequency, ranging from 12% to 71%. OBJECTIVE: To identify clinical factors associated with subclinical spread of in situ melanoma. METHODS: We used a retrospective, cross-sectional study of 674 consecutive in situ melanomas to examine 627 patients treated with Mohs surgery and melanoma antigen recognized by T cells 1 immunostaining. The presence of subclinical spread was correlated with clinical characteristics...
January 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28068959/pancreatic-neuroendocrine-tumor-with-metastasis-to-the-spleen-a-case-report
#6
Yasunaru Sakuma, Yoshikazu Yasuda, Naohiro Sata, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyuki Fukushima, Atsushi Miki, Misato Maeno, Alan Kawarai Lefor
BACKGROUND: Long-term term survival in patients with pancreatic neuroendocrine tumors has been reported, even in patients with metastatic disease. Metastases to the spleen are extremely rare, but have been reported from a number of primary malignancies, such as breast cancer, lung cancer, melanoma and ovarian cancer. This is the first report of a splenic metastasis from a primary pancreatic neuroendocrine tumor. CASE PRESENTATION: The patient presented as a 53 years old white male with anemia and fatigue...
January 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28067922/-reconstructieve-facial-surgery-in-facial-defects-after-the-surgical-removal-of-malignant-skin-tumours
#7
S Bolouri, F Bierenbroodspot, J Jansma
Because of the enormous and continuing increase in cases of skin cancer in the Netherlands, dentists will increasingly see patients with skin cancer. The most common malignant skin cancers are basal cell carcinoma, squamous cell carcinoma and malignant melanoma. With resection of a skin tumour, the oncological principles should be applied. For the closure of the resulting defect, a choice for the individual patient is made out of numerous techniques. Facial reconstructive surgery aims to restore the face in form and function and to maintain the patient's quality of life...
January 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28064232/primary-vaginal-melanoma-a-rare-and-aggressive-entity-a-case-report-and-review-of-the-literature
#8
Emmanouil Kalampokas, Theodoros Kalampokas, Christos Damaskos
: Malignant melanoma of the vagina is a rare, aggressive malignancy of poor prognosis. It principally affects post-menopausal women, with a mean age of 57 years, and the factors that contribute to its appearance are not well known. The first case of primary malignant vaginal melanoma was reported in 1887 and modern literature has noted about 500 cases, globally. Vaginal melanomas constitute 0.3% of all malignant melanomas and fewer than 3% of all vaginal carcinomas. To date there is no clear consensus regarding treatment...
January 2017: In Vivo
https://www.readbyqxmd.com/read/28061499/primary-intracranial-malignant-melanoma-with-extracranial-metastasis
#9
Kengo Hirota, Chika Yoshimura, Osami Kubo, Hidetoshi Kasuya
We report a case of primary intracranial malignant melanoma (PIMM) with extracranial metastases. The patient was an 82-year-old woman diagnosed with PIMM under the left cerebellar tentorium. We performed a tumor resection followed by gamma knife surgery. An magnetic resonance imaging at 11 months after surgery showed a local intracranial recurrence. At 12 months, vertebral metastasis was suspected, and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) showed multiple extracranial metastases...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28060744/targeting-macrophage-anti-tumor-activity-to-suppress-melanoma-progression
#10
REVIEW
Huafeng Wang, Lijuan Zhang, Luhong Yang, Chengfang Liu, Qi Zhang, Linjing Zhang
By phagocytosing cancer cells and their cellular debris, macrophages play a critical role in nonspecific defense (innate immunity) and, as antigen presenters, they help initiate specific defense mechanisms (adaptive immunity). Malignant melanoma is a lethal disease due to its aggressive capacity for metastasis and resistance to therapy. For decades, considerable effort has gone into development of an effective immunotherapy for treatment of metastatic melanoma. In this review, we focus on the anti-tumor activities of macrophages in melanoma and their potential as therapeutic targets in melanoma...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28058467/-treatment-of-melanoma-during-pregnancy
#11
REVIEW
L A Schneider
Melanoma diagnosed during pregnancy is a rare clinical case presentation which must be mastered. In the absence of guidelines for this clinical challenge, we performed a review of the literature and provide a practical guideline on how to manage such rare clinical cases based on our clinical experience. Expecting mothers require adequate counselling and explanation of all therapeutic options as they take responsibility for more than their own lives. However, they should be guided through the process of diagnostic and therapeutic measures in a potentially life-threatening situation...
January 5, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28044470/gold-nanoparticles-as-dose-enhancement-agent-for-kilovoltage-x-ray-therapy-of-melanoma
#12
So-Ra Kim, Eun-Hee Kim
PURPOSE: Melanoma is mainly treated by surgery and rarely with radiation because of the high radio-resistance of this tumor. Nevertheless, radiotherapy is the preferred treatment modality for unresectable lesions and avoiding cosmetic disfigurement caused by surgical excision. This study investigated the therapeutic advantage of gold nanoparticles (AuNPs) for kilovoltage X-ray treatment of melanoma. MATERIALS AND METHODS: Commercial AuNPs were evaluated for cytotoxicity and cellular internalization...
January 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28031389/systemic-therapy-of-brain-metastases-non-small-cell-lung-cancer-breast-cancer-and-melanoma
#13
REVIEW
Marc C Chamberlain, Christina S Baik, Vijayakrishna K Gadi, Shailender Bhatia, Laura Q M Chow
Brain metastases (BM) occur frequently in many cancers, particularly non-small cell lung cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with poor prognosis and has an adverse impact on survival and quality of life. Commonly used therapies for BM such as surgery or radiotherapy are associated with only modest benefits. However, recent advances in systemic therapy of many cancers have generated considerable interest in exploration of those therapies for treatment of intracranial metastases...
January 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28029320/pulmonary-infiltrates-in-a-patient-with-advanced-melanoma
#14
Charles A Powell
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28027809/-laparoscopic-anterior-pelvic-exenteration-in-a-patient-with-locally-advanced-melanoma
#15
David Isla-Ortiz, Gonzalo Montalvo-Esquivel, Roberto Eduardo Herrera-Goepfert, Ángel Herrera-Gómez, Rosa Angélica Salcedo-Hernández
BACKGROUND: Pelvic exenteration is one of the most mutilating surgical procedures with high post-operative morbidity. The laparoscopic technique aims to reduce perioperative complications and reduce post-surgical recovery. OBJECTIVE: We present the first case of laparoscopic anterior exenteration for locally advanced melanoma, held at the National Cancer Institute and published in Mexico. CASE REPORT: Patient 60 years of age diagnosed with invasive vulvar melanoma with bladder extension upon whom laparoscopic anterior pelvic exenteration with external urinary reconstruction was performed...
December 24, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28012127/fluorescein-sodium-guided-resection-of-cerebral-metastases-an-update
#16
Julius Höhne, Christoph Hohenberger, Martin Proescholdt, Markus J Riemenschneider, Christina Wendl, Alexander Brawanski, Karl-Michael Schebesch
BACKGROUND: Cerebral metastasis (CM) is the most common malignancy affecting the brain. In patients eligible for surgery, complete tumor removal is the most important predictor of overall survival and neurological outcome. The emergence of surgical microscopes fitted with a fluorescein-specific filter have facilitated fluorescein-guided microsurgery and identification of tumor tissue. In 2012, we started evaluating fluorescein (FL) with the dedicated microscope filter in cerebral metastases (CM)...
February 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28003758/braf-inhibitors-and-radiotherapy-for-melanoma-brain-metastases-potential-advantages-and-disadvantages-of-combination-therapy
#17
REVIEW
Mudit Chowdhary, Kirtesh R Patel, Hasan H Danish, David H Lawson, Mohammad K Khan
Melanoma is an aggressive malignancy that frequently spreads to the brain, resulting in rapid deterioration in both quality and quantity of life. Historically, treatment options for melanoma brain metastases (MBM) have predominantly consisted of surgery and radiotherapy. While these options can help provide local control, the majority of patients still develop intracranial progression. Indeed, novel therapeutic options, including molecularly targeted agents and immunotherapy, have improved outcomes and are now changing the role of radiotherapy...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27998309/a-subserosal-pedunculated-multilocular-uterine-leiomyoma-with-ovarian-tumor-like-morphology-and-histological-architecture-of-adenomatoid-tumors-a-case-report-and-review-of-the-literature
#18
Kenji Yorita, Yu Tanaka, Koki Hirano, Yuka Kai, Kaoru Arii, Kimiko Nakatani, Satoshi Ito, Toshiya Imai, Masaharu Fukunaga, Naoto Kuroda
BACKGROUND: Uterine leiomyomas are common uterine tumors, and typical cases of leiomyoma are easily diagnosed by imaging study. However, uterine leiomyomas are often altered by degenerative changes, which can cause difficulty and confusion in their clinical diagnosis. We describe the 17th reported case of a uterine leiomyoma clinically diagnosed as an ovarian tumor; however, the present case shows the most detailed radiological evaluation, including contrast-enhanced magnetic resonance imaging...
December 20, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27998306/intramammary-metastatic-melanoma-of-unknown-primary-origin-in-a-58-year-old-patient-a-case-report
#19
Zeina El-Tani, Christophe Duc, Thomas Gluecker, Olivier Cottier
BACKGROUND: Malignant melanoma metastasis to the breast is a rare disease. CASE PRESENTATION: We present the case of a 58-year-old postmenopausal Caucasian woman with metastatic malignant melanoma of unknown origin of the right breast. She presented with a palpable lump in the inferior quadrant of her right breast. The investigations concluded it was breast metastasis from a malignant melanoma of unknown origin. The treatment consisted of mastectomy and axillary lymph node dissection...
December 20, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27995057/rapidly-progressive-interstitial-lung-disease-due-to-anti-mda-5-antibody-positive-clinically-amyopathic-dermatomyositis-complicated-with-cervical-cancer-successful-treatment-with-direct-hemoperfusion-using-polymyxin-b-immobilized-fiber-column-therapy
#20
Hidenori Ichiyasu, Yasumiko Sakamoto, Chieko Yoshida, Kazuhiko Sakamoto, Ryosuke Fujita, Go Nakayama, Hiroko Okabayashi, Sho Saeki, Shinichiro Okamoto, Hirotsugu Kohrogi
The anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is a marker of clinically amyopathic dermatomyositis (CADM) and rapidly progressive interstitial lung disease (ILD) with acute respiratory failure. A 35-year-old woman with cervical cancer showed Gottron's papules, severe hypoxemia, and diffuse ground-glass opacities on chest computed tomography. She was diagnosed with rapidly progressive ILD associated with CADM. Her serum was positive for the anti-MDA-5 antibody. Combination therapy with corticosteroids, immunosuppressants, and direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP) improved her respiratory dysfunction...
2017: Respiratory Medicine Case Reports
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