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https://www.readbyqxmd.com/read/28628682/radiation-therapy-in-dermatology-non-melanoma-skin-cancer
#1
Nikoo Cheraghi, Armand Cognetta, David Goldberg
<p>Background: Dermatologists were historically well versed in the use of radiation therapy for the management of non-melanoma skin cancers and various inflammatory dermatologic conditions. With the advent of Mohs micrographic surgery and therapeutic discoveries for treating inflammatory dermatoses, radiotherapy assumed loss of a role in the clinical repertoire of the dermatologist. In recent years, its importance has again been realized for the management of non-melanoma skin cancers not amenable to surgical treatment or as adjuvant or palliative therapy...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28626949/diagnosis-and-treatment-of-concurrent-dermal-malignant-melanoma-and-melanocytomas-in-a-pygmy-hippopotamus-choeropsis-liberiensis
#2
Richard A Saunders, Rowena S Killick, Michelle G Barrows, Kelly A Bowlt, Daniella Denk
BACKGROUND: Dermal melanocytic neoplasms are common in some even-toed ungulates (Artiodactyla), yet this entity has not been reported in the pygmy hippopotamus to date. Concurrent occurrence of multiple benign and malignant melanocytic neoplasms is unusual. Malignant transformation occurs in a small percentage of benign melanocytic tumours in people but this phenomenon has not been well documented in animals. OBJECTIVES: To report the diagnosis and treatment of concurrent dermal melanocytomas and malignant melanomas in a pygmy hippopotamus...
June 18, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28624057/surveillance-strategies-in-the-follow-up-of-melanoma-patients-too-much-or-not-enough
#3
James Kurtz, Georgia M Beasley, Doreen Agnese, Kari Kendra, Thomas E Olencki, Alicia Terando, J Harrison Howard
BACKGROUND: After appropriate initial therapy for patients with stage II-III melanoma, there is no consensus regarding surveillance. Thus, follow-up is highly variable among institutions and individual providers. The National Comprehensive Cancer Network recommends routine clinical examination and consideration of imaging for stage IIB-IIIC every 3-12 mo with no distinction between stages. Detection of recurrence is important as novel systemic therapies and surgical resection of recurrence may provide survival benefits...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28620382/phase-ii-study-of-adjuvant-immunotherapy-with-the-csf-470-vaccine-plus-bacillus-calmette-guerin-plus-recombinant-human-granulocyte-macrophage-colony-stimulating-factor-vs-medium-dose-interferon-alpha-2b-in-stages-iib-iic-and-iii-cutaneous-melanoma-patients
#4
José Mordoh, María Betina Pampena, Mariana Aris, Paula Alejandra Blanco, Mónica Lombardo, Erika María von Euw, Soledad Mac Keon, Michelle Yépez Crow, Alicia Inés Bravo, Juan Manuel O'Connor, Ana Gabriela Orlando, Franco Ramello, Estrella Mariel Levy, María Marcela Barrio
The irradiated, allogeneic, cellular CSF-470 vaccine plus Bacillus Calmette-Guerin (BCG) and recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) is being tested against medium-dose IFN-α2b in stages IIB-III cutaneous melanoma (CM) patients (pts) after surgery in an open, randomized, Phase II/III study. We present the results of the Phase II part of the ongoing CASVAC-0401 study (ClinicalTrials.gov: NCT01729663). Thirty-one pts were randomized to the CSF-470 vaccine (n = 20) or to the IFN-α2b arm (n = 11)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28619614/rapid-ex-vivo-examination-of-mohs-specimens-using-optical-coherence-tomography
#5
D Rashed, D Shah, A Freeman, R J Cook, C Hopper, C M Perrett
BACKGROUND: Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo. OBJECTIVE: The aim of this prospective ex vivo study was to evaluate the efficacy of OCT in recognising healthy and pathological margins of excised BCC lesions and detecting different BCC subtypes...
June 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28618843/risk-of-cardiac-death-among-cancer-survivors-in-the-united-states-a-seer-database-analysis
#6
Omar Abdel-Rahman
 Background: Population-based data on the risk of cardiac death among cancer survivors are needed. This scenario was evaluated in cancer survivors (>5 years) registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database was queried using SEER*Stat to determine the frequency of cardiac death compared to other causes of death; and to determine heart disease-specific and cancer-specific survival rates in survivors of each of the 10 most common cancers in men and women in the SEER database...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28612483/laparoscopic-pelvic-lymph-node-dissection-for-malignant-foot-melanoma
#7
Sho Yamada, Masanori Kotake, Daiki Kakiuchi, Kengo Hayashi, Masahiro Hada, Yousuke Kato, Kaeko Oyama, Takuo Hara, Haruhisa Taizo
A 39 year-old woman with malignant foot melanoma underwent wide excision of the primary tumor with a safety margin and sentinel lymph node biopsy (SLNB) for the right inguinal lymph node. SLNB was positive and a computed tomography (CT) scan revealed right iliac lymph node swelling. Positron emission tomography computed tomography (PET-CT) scan of the lymph nodes revealed abnormal uptake of fluorodeoxyglucose (FDG). We performed a laparoscopic pelvic lymph node obturator, iliac lymph node) dissection. During the operation, several black lymph nodes were observed in the iliac lymph node...
June 13, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28609554/digit-preserving-surgery-of-subungual-melanoma-a-case-series-using-vacuum-assisted-closure-and-full-thickness-skin-grafting
#8
D Crisan, J Gülke, C Janetzko, S Kastler, N Treiber, K Scharffetter-Kochanek, L A Schneider
Acrolentiginous melanoma (ALM) is the second most common nail organ tumour and frequently, affects the thumb or the great toe.(1,2) Digit amputation is still the gold standard for many surgeons;(3) it does, however, not protect against local recurrence. An alternative represents complete tumour resection with distal phalanx preservation, which has proven valuable, especially for well demarcated thinner tumours.(4,5) This article is protected by copyright. All rights reserved.
June 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28605380/establishment-of-a-clinic-based-biorepository
#9
Sarah E Belden, Chandana K Uppalapati, Agnes S Pascual, McKale R Montgomery, Kathryn J Leyva, Elizabeth E Hull, Richard L Averitte
The incidence of skin cancer (e.g., squamous cell carcinoma, basal cell carcinoma, and melanoma) has been increasing over the past several years. It is expected that there will be a parallel demand for cutaneous tumor samples for biomedical research studies. Tissue availability, however, is limited due the cost of establishing a biorepository and the lack of protocols available for obtaining clinical samples that do not interfere with clinical operations. A protocol was established to collect and process cutaneous tumor and associated blood and saliva samples that has minimal impact on routine clinical procedures on the date of a Mohs surgery...
May 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28604229/review-the-re-emergence-of-brachytherapy-as-treatment-for-non-melanoma-skin-cancer
#10
Koji Ota, Tony Adar, Laura Dover, Amor Khachemoune
Electronic Brachytherapy (EBT) has seen a significant rise in use over the past few years in treating non-melanoma skin cancer (NMSC). However, the current literature in EBT remains scarce. Existing data on high dose rate brachytherapy (HDR-BT) with surface applicators is often used to justify its efficacy and safety. In this review we study the two treatment modalities on their efficacy in treating NMSC and we explore the reasons behind the recent uprise in EBT. A literature review using PubMed was performed for articles published until January 2017 studying efficacy of HDR-BT and EBT for treating NMSC...
June 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28597996/sensitization-of-melanoma-cells-to-temozolomide-by-overexpression-of-microrna-203-through-direct-targeting-of-glutaminase-mediated-glutamine-metabolism
#11
X Chang, W Zhu, H Zhang, S Lian
BACKGROUND: Malignant melanoma (MM) is an aggressive malignancy, which accounts for 80% of skin cancer-related deaths and is notably resistant to conventional chemotherapeutic agents. One of the most common treatments for melanoma is surgery, followed by various combinations of chemotherapy drugs. AIM: To investigate the role of microRNA (miR)-203 in sensitivity of MM cells to the chemotherapy drug temozolomide (TMZ). METHODS: Using quantitative reverse transcription PCR, we measured the expression of miR-203 in an MM cell line...
June 9, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28596284/prognostic-biopsy-of-choroidal-melanoma-an-optimised-surgical-and-laboratory-approach
#12
Martina Angi, Helen Kalirai, Azzam Taktak, Rumana Hussain, Carl Groenewald, Bertil E Damato, Heinrich Heimann, Sarah E Coupland
BACKGROUND: Accurate survival prognostication for patients with uveal melanoma (UM) enables effective patient counselling and permits personalised systemic surveillance for the early detection of metastases and, in high-risk patients, enrolment in any trials of systemic adjuvant therapy. The aim of this work is to determine the success of prognostic UM tumour biopsy using an improved surgical approach and optimised sample handling workflow. METHODS: Patients with UM treated by primary radiotherapy between 2011 and 2013 and who underwent a prognostic biopsy with cytology, multiplex ligation-dependent probe amplification and/or microsatellite analysis were included...
June 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28582297/loco-regional-control-with-complete-resection-and-tongue-reconstruction-on-the-malignant-melanoma-in-the-tongue
#13
Tuqa Alkaff, Woo Shik Jeong, Soon Yuhl Nam, Jong Woo Choi
Primary malignant melanoma in the tongue is very uncommon disease that is considered low in comparison to cutaneous melanoma. In this report, the authors described a case of the hemitongue reconstruction with fasciocutaneous free flap on the patient who suffered from the malignant melanoma primarily originating from the base of the tongue that was treated with surgery and radiotherapy but developed a lung metastasis. A 76-year-old man was referred to the otorhinolaryngology clinic after complaining of a painful mass present for 3 months on the right side of the tongue...
June 2, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28578123/outcome-evaluation-of-patients-with-limited-brain-metastasis-from-malignant-melanoma-treated-with-surgery-radiation-therapy-and-targeted-therapy
#14
Federico Pessina, Pierina Navarria, Stefano Tomatis, Luca Cozzi, Ciro Franzese, Lorenza Di Guardo, Anna Maria Ascolese, Giacomo Reggiori, Davide Franceschini, Michele Del Vecchio, Lorenzo Bello, Marta Scorsetti
OBJECTIVE: The incidence of brain metastases from melanoma is increasing. Several effective treatment options are now available but what can be considered the optimal therapeutic strategy is not yet defined. We evaluated the outcome of brain metastatic melanoma patients in terms of local control rate, brain distant progression and overall survival. MATERIALS AND METHODS: The present retrospective study includes only patients with limited brain metastases (≤4) underwent surgery plus stereotactic radiosurgery (SRS), or SRS alone...
May 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28570726/cost-effectiveness-of-early-division-of-the-forehead-flap-pedicle
#15
Hollin E Calloway, Sami P Moubayed, Sam P Most
Importance: The paramedian forehead flap is considered the gold standard procedure to optimally reconstruct major defects of the nose, but this procedure generally requires 2 stages, where the flap pedicle is divided 3 weeks following the initial surgery to ensure adequate revascularization of the flap from the surrounding recipient tissue bed, which can cost a patient time out of work or away from normal social habits. It has previously been shown that the pedicle may be safely divided after 2 weeks in select patients where revascularization from the recipient bed was confirmed using intraoperative laser fluorescence angiography to potentially save the patient time and money...
June 1, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28569457/advances-in-radioguided-surgery-in-oncology
#16
Renato A Valdés Olmos, Sergi Vidal-Sicart, Gianpiero Manca, Giuliano Mariani, Luisa F León-Ramírez, Domenico Rubello, Francesco Giammarile
The sentinel lymph node (SLN) biopsy is probably the most well known radioguided technique in surgical oncology. Today SLN biopsy reduces the morbidity associated with lymphadenectomy and increases the identification rate of occult lymphatic metastases by offering the pathologist the lymph nodes with the highest probability of containing metastatic cells. These advantages may result in a change in clinical clinical management both in melanoma and breast cancer patients. The SLN evaluation by pathology currently implies tumour burden stratification for further prognostic information...
June 1, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28562565/perivascular-epithelial-cell-tumor-pecoma-of-the-pancreas-a-case-report-and-review-of-literature
#17
Shuisheng Zhang, Fang Chen, Xiaozhun Huang, Qinglong Jiang, Yajie Zhao, Yingtai Chen, Jianwei Zhang, Jie Ma, Wei Yuan, Quan Xu, Jiuda Zhao, Chengfeng Wang
RATIONALE: Perivascular epithelial cell tumors (PEComas) of the pancreas are rare mesenchymal tumors and, to our knowledge, only 20 cases have been reported to date. PATIENT CONCERNS: We report a 43-year-old female who presented with upper abdominal pain for 1 year. She underwent an exploratory laparotomy at a local hospital, which failed to resect the tumor. Five months later, she came to the Chinese National Cancer Center for surgery. Preoperative imaging revealed an 11...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28555249/anatomy-of-the-cutaneous-lymphatic-system-of-the-trunk-a-clinico-anatomical-study-of-90-cutaneous-melanomas
#18
A Bonmarchand, D Coquerel-Beghin, A B Duval-Modeste, J Le Cloirec, F Duparc, I Auquit-Auckbur
PURPOSE: The cutaneous lymphatic system of the trunk is a complex network, the anatomical knowledge of which remains unclear. The lymphatic system plays a major role in the dissemination of lymphophilic cancers like melanomas. The aim of this study was to improve our knowledge, optimize the care of patients with cutaneous tumors of the trunk, and to use our clinical experience of the topography of pathologic lymph nodes related to cutaneous melanomas and depicted by lymphoscintigraphy...
May 29, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28551895/-sentinel-lymph-nodes-dissection-in-gynecological-malignancies
#19
REVIEW
Yael Naaman, Limor Goldenhersh, Alon Ben-Arie
During the last decade sentinel lymph nodes biopsy has become an essential part of primary surgical treatment in a number of malignancies including breast cancer, melanoma and head-and-neck malignancies. Dye or radioactive substances are injected at the primary tumor site, followed by pre-operative and intra-operative mapping. During surgery only positive lymph nodes are being dissected instead of a complete dissection of the lymphatic basin. The advantages of sentinel lymph nodes dissection are reducing the side effects of extensive lymph nodes dissection, while maintaining high detection rates and sensitivity in identifying cases with lymphatic tumor spread...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28550655/primary-malignant-melanoma-of-esophagus-following-chemoradiotherapy-for-esophageal-squamous-cell-carcinoma-report-of-a-case
#20
Shinichiro Imai, Akira Suzuki, Yuta Yamamoto, Makoto Koyama, Satoshi Sugiyama, Masato Kitazawa, Yusuke Miyagawa, Shinichi Miyagawa
Primary malignant melanoma of the esophagus (PMME) is a rare neoplasm. We observed a case of PMME that had occurred at an irradiated site in the thoracic esophagus. The patient was a 74-year-old man who had received definitive chemoradiotherapy for esophageal squamous cell carcinoma at the age of 68, and had completely recovered. Six years later, via periodic upper gastrointestinal endoscopy, he had been diagnosed with esophageal tumors. After the patient underwent esophagectomy, the removed esophageal tumors were immunohistologically diagnosed as PMME, and most of the tumor was observed to be located within the irradiated area corresponding to the previous radiotherapy...
May 26, 2017: Clinical Journal of Gastroenterology
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