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https://www.readbyqxmd.com/read/29342417/a-study-of-the-cost-effectiveness-of-fenestrated-branched-evar-compared-with-open-surgery-for-patients-with-complex-aortic-aneurysms-at-2-years
#1
Morgane Michel, Jean-Pierre Becquemin, Jean Marzelle, Céline Quelen, Isabelle Durand-Zaleski
OBJECTIVES: The aim was to assess the cost-effectiveness of fenestrated and branched stent grafts (f/b EVAR) compared with open surgical repair (OSR) in thoraco-abdominal or complex abdominal aortic aneurysms (TAAA/AAA) at 2 years. METHODS: Two matched cohorts of patients with TAAA or complex AAA were compared after a follow-up of two years. Patients included in the WINDOW French multicentre prospective registry were treated by f/b EVAR, and OSR patients were extracted from the French national hospital discharge database...
January 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29342309/prognostic-power-of-a-tumor-differentiation-gene-signature-for-bladder-urothelial-carcinomas
#2
Qianxing Mo, Fotis Nikolos, Fengju Chen, Zoe Tramel, Yu-Cheng Lee, Kazukuni Hayashi, Jing Xiao, Jianjun Shen, Keith Syson Chan
Background: Muscle-invasive bladder cancers (MIBCs) cause approximately 150 000 deaths per year worldwide. Survival for MIBC patients is heterogeneous, with no clinically validated molecular markers that predict clinical outcome. Non-MIBCs (NMIBCs) generally have favorable outcome; however, a portion progress to MIBC. Hence, development of a prognostic tool that can guide decision-making is crucial for improving clinical management of bladder urothelial carcinomas. Methods: Tumor grade is defined by pathologic evaluation of tumor cell differentiation, and it often associates with clinical outcome...
January 12, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29342228/labiaplasty-indications-and-predictors-of-postoperative-sequelae-in-451-consecutive-cases
#3
Alexandra Bucknor, Austin D Chen, Sabine Egeler, Patrick Bletsis, Anna Rose Johnson, Kate Myette, Samuel J Lin, Christine A Hamori
Background: The increasing demand for labiaplasty is well recognized; however, the procedure remains contentious. Objectives: We aim to provide a large-scale, up-to-date analysis of labiaplasty outcomes and factors influencing postoperative sequelae (POS). Methods: We analyzed a single-center, prospectively maintained database of females undergoing labiaplasty between 2002 and 2017. Demographic, procedural, and outcomes' data were retrieved...
January 9, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29342063/low-prevalence-of-hip-and-knee-arthritis-in-active-marathon-runners
#4
Danielle Y Ponzio, Usman Ali M Syed, Kelly Purcell, Alexus M Cooper, Mitchell Maltenfort, Julie Shaner, Antonia F Chen
BACKGROUND: Existing evidence on whether marathon running contributes to hip and knee arthritis is inconclusive. Our aim was to describe hip and knee health in active marathon runners, including the prevalence of pain, arthritis, and arthroplasty, and associated risk factors. METHODS: A hip and knee health survey was distributed internationally to marathon runners. Active marathoners who completed ≥5 marathons and were currently running a minimum of 10 miles per week were included (n = 675)...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29341816/red-cell-indexes-made-easy-using-an-interactive-animation-do-students-and-their-scores-concur
#5
Upasana Kachroo, Elizabeth Vinod, Sivakumar Balasubramanian, Jesi W, Neetu Prince
A good understanding of red cell indexes can aid medical students in a considerable manner, serving as a basis to unravel both concepts in red cell physiology and abnormalities associated with the same. In this study, we tried to assess whether an interactive animation was helpful in improving student comprehension and understanding of red cell indexes compared with conventional classroom teaching. Eighty-eight first-year MBBS students participated, of which 44 were assigned to group A and 44 were assigned to group B after randomization...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29341660/2d-stress-tensor-for-4d-gravity
#6
Daniel Kapec, Prahar Mitra, Ana-Maria Raclariu, Andrew Strominger
We use the subleading soft-graviton theorem to construct an operator T_{zz} whose insertion in the four-dimensional tree-level quantum gravity S matrix obeys the Virasoro-Ward identities of the energy momentum tensor of a two-dimensional conformal field theory (CFT_{2}). The celestial sphere at Minkowskian null infinity plays the role of the Euclidean sphere of the CFT_{2}, with the Lorentz group acting as the unbroken SL(2,C) subgroup.
September 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341487/identification-of-stress-related-microrna-biomarkers-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#7
Yingzhi Liang, Li Jiajianghui, Huanbo Xiao, Yan He, Ling Zhang, Yuxiang Yan
BACKGROUND: Many studies have investigated miRNAs in the detection of type 2 diabetes mellitus (T2DM). Here, the dysregulated direction of stress-related miRNAs that used as biomarkers of T2DM was summarized and analyzed. METHODS: PubMed, EMBASE, ISI web of science and three Chinese databases were searched for case-control miRNA profiling studies about T2DM. A meta-analysis under a random effect was performed. Subgroup analysis was conducted based on different tissues and species, respectively...
January 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29341479/nuclear-division-cycle-80-promotes-malignant-progression-and-predicts-clinical-outcome-in-colorectal-cancer
#8
Xuebing Yan, Linsheng Huang, Liguo Liu, Huanlong Qin, Zhenshun Song
Colorectal cancer (CRC) is a common human malignancy worldwide and increasing studies have attributed its malignant progression to abnormal molecular changes in cancer cells. Nuclear division cycle 80 (NDC80) is a newly discovered oncoprotein that regulates cell proliferation and cycle in numerous malignancies. However, its clinical significance and biological role in CRC remain unclear. Therefore, in this study, we firstly analyze its expression in a retrospective cohort enrolling 224 CRC patients and find its overexpression is significantly correlated with advanced tumor stage and poor prognosis in CRC patients...
January 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29341439/therapeutic-benefits-of-cd90-negative-cardiac-stromal-cells-in-rats-with-a-30-day-chronic-infarct
#9
Deliang Shen, Miaoda Shen, Hongxia Liang, Junnan Tang, Bo Wang, Chuang Liu, Peiwen Wang, Jianzeng Dong, Ling Li, Jinying Zhang, Thomas G Caranasos
Cardiac stromal cells (CSCs) can be derived from explant cultures, and a subgroup of these cells is viewed as cardiac mesenchymal stem cells due to their expression of CD90. Here, we sought to determine the therapeutic potential of CD90-positive and CD90-negative CSCs in a rat model of chronic myocardial infarction. We obtain CD90-positive and CD90-negative fractions of CSCs from rat myocardial tissue explant cultures by magnetically activated cell sorting. In vitro, CD90-negative CSCs outperform CD90-positive CSCs in tube formation and cardiomyocyte functional assays...
January 17, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29341381/effect-of-ethanol-on-the-antimicrobial-properties-of-chlorhexidine-over-oral-biofilm
#10
Pedro Henrique Marks Duarte, Paula Barcellos da Silva, Ricardo Abreu da Rosa, Francisco Montagner, Marco Antônio Húngaro Duarte, Milton Carlos Kuga, Marcus Vinícius Reis Só
The aim of this study was to evaluate the effect of 95% ethanol irrigation, with 5 or 10 min of action, on the antibacterial properties of 2% chlorhexidine (CHX), on oral biofilm, evaluated with confocal laser scanning microscopy (CLSM). Oral biofilm development was induced in 80 sterilized bovine dentin blocks, distributed in two groups (5 or 10 min) and 4 subgroups, according to time and the solution used: Saline (SALINE5, SALINE10); Saline followed by CHX (SALINE/CHX5, SALINE/CHX10); Ethanol (ETHANOL5, ETHANOL10), Ethanol followed by CHX (ETHANOL/CHX5, ETHANOL/CHX10)...
January 17, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29341294/topical-nitroglycerin-for-the-treatment-of-intraoperative-microsurgical-vasospasm
#11
Joseph A Ricci, Dhruv Singhal, Eugene Y Fukudome, Adam M Tobias, Samuel J Lin, Bernard T Lee
BACKGROUND: Papaverine remains a popular agent to treat intraoperative microsurgical vasospasm. However, the recent shortage has forced surgeons to trial antispasmodic agents unproven in microsurgery, but commonly used in other areas. During this shortage we have trialed topical nitroglycerin to break intraoperative vasospasm. This study aims to analyze the outcomes of this medication on flap complications compared with papaverine. METHODS: All consecutive free flaps performed for breast reconstruction at a single institution were reviewed...
January 17, 2018: Microsurgery
https://www.readbyqxmd.com/read/29341286/test-1-analyzer-and-conventional-westergren-method-for-erythrocyte-sedimentation-rate-a-comparative-study-between-two-laboratories
#12
Cigdem Sonmez, Ozlem Ceylan Dogan, Aysegul Ozturk Kaymak, Nedim Akkaya, Kadir Okhan Akin, Gulcan Guntas
BACKGROUND: Measurement of the length of sedimentation reaction in blood (LSRB), also called erythrocyte sedimentation rate (ESR), is a widely used hematology test. This study intends to compare ESR levels measured by Test-1 method and International Council for Standardization in Hematology's (ICSH) reference method, and analyzes the effect of hematocrit (Hct) on ESR results. MATERIAL AND METHODS: A total of 755 patients from 2 hospitals were included in the study, and samples with EDTA were studied by Test-1 method for ESR measurement and total blood count, whereas citrated samples were studied with reference Westergren method...
January 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29341195/association-between-circulating-25-hydroxyvitamin-d-levels-and-psoriasis-and-correlation-with-disease-severity-a-meta-analysis
#13
Y H Lee, G G Song
BACKGROUND: Psoriasis is a chronic, autoimmune, inflammatory skin disorder. 25-hydroxy vitamin D [25(OH)D] deficiency may contribute to the pathogenesis of psoriasis through reduction in antiproliferative, anti-inflammatory and antiangiogenic activities. AIM: To evaluate the relationship between circulating 25(OH)D levels and psoriasis, and to determine the correlation between serum/plasma 25(OH)D levels and psoriasis severity. METHODS: We performed a meta-analysis to compare serum/plasma 25(OH)D levels between patients with psoriasis and healthy controls (HCs), and to determine the correlation coefficients between circulating 25(OH)D levels and psoriasis severity as assessed by Psoriasis Area and Severity Index (PASI)...
January 16, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29341157/minimizing-inequality-in-access-to-precision-medicine-in-breast-cancer-by-real-time-population-based-molecular-analysis-in-the-scan-b-initiative
#14
L Rydén, N Loman, C Larsson, C Hegardt, J Vallon-Christersson, M Malmberg, H Lindman, A Ehinger, L H Saal, Å Borg
BACKGROUND: Selection of systemic therapy for primary breast cancer is currently based on clinical biomarkers along with stage. Novel genomic tests are continuously being introduced as more precise tools for guidance of therapy, although they are often developed for specific patient subgroups. The Sweden Cancerome Analysis Network - Breast (SCAN-B) initiative aims to include all patients with breast cancer for tumour genomic analysis, and to deliver molecular subtype and mutational data back to the treating physician...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29341152/meta-analysis-of-the-prognostic-value-of-cpg-island-methylator-phenotype-in-gastric-cancer
#15
REVIEW
A G M T Powell, S Soul, A Christian, W G Lewis
BACKGROUND: CpG island methylator phenotype (CIMP) has been identified as a distinct molecular subtype of gastric cancer, yet associations with survival are conflicting. A meta-analysis was performed to estimate the prognostic significance of CIMP. METHODS: Embase, MEDLINE, PubMed, PubMed Central and Cochrane databases were searched systematically for studies related to the association between CIMP and survival in patients undergoing potentially curative resection for gastric cancer...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29340973/reference-intervals-for-thyrotropin-in-an-area-of-northern-italy-the-pordenone-thyroid-study-tripp
#16
R Tozzoli, F D'Aurizio, P Metus, A Steffan, C Mazzon, M Bagnasco
PURPOSE: Thyrotropin (TSH) is the most accurate marker of thyroid dysfunction in the absence of pituitary or hypothalamic disease. Studies on TSH reference intervals (RIs) showed wide inter-individual variability and prompted an intense debate about the best estimation of TSH RIs. DESIGN: We performed a population study on TSH RIs, using current data stored in the laboratory information system (LIS), at the Hospital Department of Laboratory Medicine, Pordenone (Italy), historically an area of mild-moderate iodine deficiency with a relatively high goiter prevalence...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29340961/metabolic-syndrome-and-its-components-among-korean-submariners-a-retrospective-cross-sectional-study
#17
Jihun Kang, Yun-Mi Song
PURPOSE: Metabolic syndrome (MetS) is a cluster of inter-related risk factors for cardiovascular disease and diabetes. Although submariners tend to be exposed to unhealthy environmental factors, such as a confined work environment, physical inactivity, and circadian disruption, little is known regarding whether the risks of MetS and its components are associated with submarine service. The present study aimed to evaluate the risks of MetS and its components among submariners. METHODS: A total of 5090 subjects (513 submariners and 4577 non-submariners) were included in the present study...
January 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29340908/fasting-blood-glucose-level-in-locally-advanced-non-small-cell-lung-cancer-a-new-prognostic-factor
#18
Esra Korkmaz Kirakli, Ufuk Yilmaz, Hasan Yilmaz, Berna Komurcuoglu
Hyperglycemia may lead to proliferation, invasion, apoptosis inhibition, migration, and eventually metastasis of cancer cells by several mechanisms. In this study, the effect of hyperglycemia on overall survival (OS), disease-free survival (DFS), and locoregional recurrence (LRR) was investigated in NSCLC. One stage IIIA-IIIB NSCLC patient treated with chemoradiotherapy between 2010 and 2015 was enrolled. Fasting blood glucose (FBG) levels were recorded in pre-treatment, treatment, and post-treatment periods...
January 16, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29340906/an-exploratory-study-on-the-intergenerational-transmission-of-obesity-and-dieting-proneness
#19
Elizabeth A Claydon, Keith J Zullig, Christa L Lilly, Stephanie C Zerwas, Danielle M Davidov, Lesley Cottrell, Marney A White
PURPOSE: There is a paucity of research exploring individuals' memories of parental dieting behavior, engagement in "fat talk", or criticism of weight or eating behavior in childhood. This exploratory study utilized a community sample to further characterize the retrospective report of parenting dieting behavior. METHODS: A total of 507 participants (78.1% females; 20.7% males; and 1.2% transgender) were recruited to participate in an online, self-administered survey...
January 16, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29340905/expression-of-vhl-tumor-suppressor-mrna-and-mir-92a-in-papillary-thyroid-carcinoma-and-their-correlation-with-clinical-and-pathological-parameters
#20
Lidija Todorović, Boban Stanojević, Vesna Mandušić, Nina Petrović, Vladan Živaljević, Ivan Paunović, Aleksandar Diklić, Vladimir Saenko, Shunichi Yamashita
A growing body of evidence suggests a role of the von Hippel-Lindau (VHL) tumor suppressor gene in the progression of papillary thyroid carcinoma (PTC). Our previous study of VHL in PTCs showed that lower VHL expression was associated with aggressive tumor features, but we found no evidence for VHL downregulation through common genetic or epigenetic modifications. Several studies pointed to a role of microRNA-92a (miR-92a) in the regulation of VHL expression in different cancers. In the present study, we examined the expression levels of VHL mRNA and miR-92a in 42 pairs of PTCs and matched non-tumor thyroid tissues by means of quantitative RT-PCR...
January 16, 2018: Medical Oncology
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