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https://www.readbyqxmd.com/read/28724270/synergistic-effects-of-ad-libitum-low-dose-fructose-drinking-and-low-dose-streptozotocin-treatment-in-wistar-rats-a-mild-model-of-type-2-diabetes
#1
Asie Sadeghi, Maani Beigy, Samira Alizadeh, Hossein Mazloom, Sanaz Vakili, Saideh Ahmadi, Reza Meshkani
To develop a convenient animal model of T2D by pretreatment with low-dose 10% w/v fructose (FRC) solution followed by the injection of low doses of streptozotocin (STZ) in Wistar rats. For this 8-week experimental study; rats were first fed a standard chow ad-libitum diet and either tap water (n=40) or 10% w/v FRC solution (n=40) for 4 weeks. Next, rats in each category were randomly allocated to 4 subgroups (n=10 each) of low-dose STZ (25,35, and 45 mg/kg). The final mean fasting blood sugar (FBG) of FRC+STZ45 (197±55...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28724229/microbial-association-with-the-dynamics-of-particulate-organic-carbon-in-response-to-the-amendment-of-elevated-co2-derived-wheat-residue-into-a-mollisol
#2
Yanhong Wang, Zhenhua Yu, Yansheng Li, Guanghua Wang, Junjie Liu, Judong Liu, Xiaobing Liu, Jian Jin
As the chemical quality of crop residue is likely to be affected by elevated CO2 (eCO2), residue amendments may influence soil organic carbon (SOC) sequestration. However, in Mollisols, the dynamics of the SOC fractions in response to amendment with wheat residue produced under eCO2 and the corresponding microbial community composition remain unknown. Such investigation is essential to residue management, which affects the soil quality and productivity of future farming systems. To narrow this knowledge gap, (13)C-labeled shoot and root residue derived from ambient CO2 (aCO2) or eCO2 were amended into Mollisols and incubated for 200days...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724193/saline-irrigation-for-the-management-of-skin-extravasation-injury-in-neonates
#3
REVIEW
P N Gopalakrishnan, Nitin Goel, Sujoy Banerjee
BACKGROUND: Extravasation injury, a complication commonly seen in the neonatal intensive care unit, can result in scarring with cosmetic and functional sequelae. A wide variety of treatments are available, including subcutaneous irrigation with saline (with or without hyaluronidase), liposuction, use of specific antidotes, topical applications, and normal wound care with dry or wet dressings. All such treatments aim to prevent or reduce the severity of complications. OBJECTIVES: Primary objective To compare the efficacy and safety of saline irrigation or saline irrigation with prior hyaluronidase infiltration versus no intervention or normal wound care for tissue healing in neonates with extravasation injury...
July 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28724038/sexual-addiction-in-drug-addicts-the-impact-of-drug-of-choice-and-poly-addiction
#4
Nelson Antonio, Alessandra Diehl, Marcelo Niel, Sandra Pillon, Lilian Ratto, Maria Carolina Pinheiro, Dartiu Silveira, Thais Zelia Otani, Victor Otani, Quirino Cordeiro, Ricardo Ushida
Objective: To compare the risk of comorbid sexual addiction in a sample of individuals with a diagnosis of substance dependence, stratifying the sample by drug of choice as well as by mono versus polysubstance addiction. Method: All data were collected at Santa Casa de São Paulo, Brazil. The study sample comprised all alcohol or drug dependents admitted to the Addiction Treatment Unit between November 2013 and August 2014. A generalized linear model with a binomial distribution was performed to compare the odds of having a Sexual Addiction Screening Test (SAST) score greater than 6 points in the subgroups analyzed...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28723910/estimating-mono-and-bi-phasic-regression-parameters-using-a-mixture-piecewise-linear-bayesian-hierarchical-model
#5
Rui Zhao, Paul Catalano, Victor G DeGruttola, Franziska Michor
The dynamics of tumor burden, secreted proteins or other biomarkers over time, is often used to evaluate the effectiveness of therapy and to predict outcomes for patients. Many methods have been proposed to investigate longitudinal trends to better characterize patients and to understand disease progression. However, most approaches assume a homogeneous patient population and a uniform response trajectory over time and across patients. Here, we present a mixture piecewise linear Bayesian hierarchical model, which takes into account both population heterogeneity and nonlinear relationships between biomarkers and time...
2017: PloS One
https://www.readbyqxmd.com/read/28723881/correlation-between-pao2-fio2-and-peripheral-capillary-oxygenation-fio2-in-burned-children-with-smoke-inhalation-injury
#6
Janos Cambiaso-Daniel, Charles D Voigt, Eric Rivas, Gabriel Hundeshagen, Omar Nunez-Lopez, Lars-Peter Kamolz, Michaela Sljivich, Linda E Sousse, David N Herndon, Oscar E Suman, Michael P Kinsky, Ronald P Mlcak
OBJECTIVES: Determine whether the peripheral capillary oxygenation/FIO2 ratio correlates with the PaO2/FIO2 ratio in burned children with smoke inhalation injury, with the goal of understanding if the peripheral capillary oxygenation/FIO2 ratio can serve as a surrogate for the PaO2/FIO2 ratio for the diagnosis of acute respiratory distress syndrome. DESIGN: Retrospective chart review. SETTING: Shriners Hospitals for Children-Galveston. PATIENTS: All burned children with smoke inhalation injury who were admitted from 1996 to 2014 and had simultaneously obtained peripheral capillary oxygenation, FIO2 and PaO2 measurements...
July 18, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28723867/prediction-of-severe-toxicity-in-adult-patients-under-treatment-with-5-fluorouracil-a-prospective-cohort-study
#7
Carolina Vázquez, María Orlova, Federico Angriman, José N Minatta, Paula Scibona, María A Verzura, Esteban G Jáuregui, Heidy Díaz de Arce, María G Pallotta, Waldo H Belloso
5-Fluorouracil (5-FU) has long been used for the treatment of gastrointestinal tumors harboring interindividual variability in both the pharmacokinetic and the pharmacogenetic profiles, which in turn may lead to life-threatening toxicities. We carried out a prospective cohort study of adult patients initiating treatment with 5-FU between 2013 and 2015. Primary exposures of interest were the methylenetetrahydrofolate reductase single nucleotide polymorphism in exons 4 and 7 and 5'-untranslated region-thymidylate synthase VNTR genotypes, in addition to baseline clinical and demographic variables...
July 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28723854/use-of-colorectal-cancer-screening-among-people-with-mobility-disability
#8
Miriam Gofine, Thelma J Mielenz, Sowmya Vasan, Benjamin Lebwohl
GOALS: We aimed to assess use of colorectal cancer screening (CRCS) as per United States Preventive Task Force guidelines among people with mobility disability using a nationally representative data set. BACKGROUND: Individuals with mobility disability have decreased access to health care services, but the impact of mobility disability on CRCS has not been investigated. STUDY: Data from the 2013 National Health Interview Survey were used to estimate sociodemographic characteristics of adults with mobility disability, prevalence of CRCS, and odds of CRCS given mobility disability among Americans aged 50 to 75...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723804/microvessel-density-as-a-prognostic-factor-in-esophageal-squamous-cell-cancer-patients-a-meta-analysis
#9
Guangzhi Ma, Jing Zhang, Hai Jiang, Nannan Zhang, Yunjie Zhu, Yunfu Deng, Qinghua Zhou
BACKGROUND: To date, literature has emerged that shows contradictory results about the prognostic role of microvessel density (MVD) in esophageal squamous cell cancer (ESCC). The aim of the study set out to evaluate the correlation between MVD and the prognosis of ESCC. METHODS: Identified publications from various databases were obtained and reviewed. A meta-analysis was performed to evaluate the prognostic role of MVD among ESCC patients. RESULTS: A total of 11 eligible studies containing 891 ESCC cases were included in the meta-analysis...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723793/prognostic-value-of-neutrophil-to-lymphocyte-ratio-for-nasopharyngeal-carcinoma-a-meta-analysis
#10
Jun Yin, Yuan Qin, Yu-Kun Luo, Mei Feng, Jin-Yi Lang
BACKGROUND: The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for nasopharyngeal carcinoma (NPC) remains controversial. This study was designed to provide a more accurate assessment of the prognostic value, based on a meta-analysis. METHODS: A comprehensive search for relevant studies published before June 2016 was performed using the PubMed, Cochrane Library, and Web of Science databases. The correlations of NLR with overall survival (OS) and progression-free survival (PFS) were evaluated for NPC...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723763/the-diagnostic-value-of-assays-for-circulating-tumor-cells-in-hepatocellular-carcinoma-a-meta-analysis
#11
Chi Sun, Wenjun Liao, Zefu Deng, Enliang Li, Qian Feng, Jun Lei, Rongfa Yuan, Shubing Zou, Yilei Mao, Jianghua Shao, Linquan Wu, Chao Zhang
PURPOSE: Circulating tumor cells (CTCs) are considered potential biomarkers for the detection of hepatocellular carcinoma (HCC). Many studies have attempted to explore this role, but the results are variable. We conducted the first comprehensive meta-analysis to evaluate the diagnostic value of CTC assay for HCC patients. Additional prognostic value was also assessed. EXPERIMENTAL DESIGN: All articles included in our study were assessed using QUADAS guidelines after a literature search...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723761/efficacy-of-the-prophylactic-use-of-octreotide-for-the-prevention-of-complications-after-pancreatic-resection-an-updated-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
Chunli Wang, Xin Zhao, Shengyi You
BACKGROUND: The use of octreotide prophylaxis in the prevention of complications after pancreatic resection remains controversial. The aim of this systematic review and meta-analysis was to evaluate the efficacy of octreotide prophylactic treatment to prevent complications after pancreatic resection. METHODS: Five databases (PubMed, Medline, SinoMed, Embase, and Cochrane Library) were searched for eligible studies from 1980 to November 2016 with the limitation of human subjects and randomized controlled trials (RCTs)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723739/efficacy-and-safety-of-bivalirudin-versus-heparin-in-patients-with-diabetes-mellitus-undergoing-percutaneous-coronary-intervention-a-meta-analysis-of-randomized-controlled-trials
#13
Juan Zhang, Xinchun Yang
BACKGROUND: The efficacy and safety of bivalirudin (Biva) versus heparin in patients with diabetes mellitus (DM) who undergo percutaneous coronary intervention (PCI) remain controversial. Our meta-analysis was undertaken to evaluate the efficacy and safety of Biva compared with those of heparin in patients with diabetes undergoing PCI. METHODS: We searched PubMed, EMBASE, Cochrane Library, and Clinical Trials.gov databases for randomized controlled trials (RCTs)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723717/localized-muscle-vibration-reverses-quadriceps-muscle-hypotrophy-and-improves-physical-function-a-clinical-and-electrophysiological-study
#14
Maria Grazia Benedetti, Gennaro Boccia, Lorenzo Cavazzuti, Elena Magnani, Elisabetta Mariani, Alberto Rainoldi, Roberto Casale
Quadriceps weakness has been associated with knee osteoarthritis (OA). High-frequency localized muscle vibration (LMV) has been proposed recently for quadriceps strengthening in patients with knee OA. The purpose of this study was (a) to investigate the clinical effectiveness of high-frequency LMV on quadriceps muscle in patients with knee OA and (b) to disentangle, by means of surface electromyography (sEMG), the underlying mechanism. Thirty patients, aged between 40 and 65 years, and clinically diagnosed with knee OA were included in this randomized, controlled, single-blinded pilot study...
July 18, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28723675/tumor-antigen-ca125-suppresses-antibody-dependent-cellular-cytotoxicity-adcc-via-direct-antibody-binding-and-suppressed-fc-%C3%AE-receptor-engagement
#15
J Bradford Kline, Rina P Kennedy, Earl Albone, Qimin Chao, Shawn Fernando, Jennifer M McDonough, Katherine Rybinski, Wenquan Wang, Elizabeth B Somers, Charles Schweizer, Luigi Grasso, Nicholas C Nicolaides
Cancers employ a number of mechanisms to evade host immune responses. Here we report the effects of tumor-shed antigen CA125/MUC16 on suppressing IgG1-mediated antibody-dependent cellular cytotoxicity (ADCC). This evidence stems from prespecified subgroup analysis of a Phase 3 clinical trial testing farletuzumab, a monoclonal antibody to folate receptor alpha, plus standard-of-care carboplatin-taxane chemotherapy in patients with recurrent platinum-sensitive ovarian cancer. Patients with low serum CA125 levels treated with farletuzumab demonstrated improvements in progression free survival (HR 0...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723661/decreased-risk-of-dementia-in-migraine-patients-with-traditional-chinese-medicine-use-a-population-based-cohort-study
#16
Chun-Ting Liu, Bei-Yu Wu, Yu-Chiang Hung, Lin-Yi Wang, Yan-Yuh Lee, Tsu-Kung Lin, Pao-Yen Lin, Wu-Fu Chen, Jen-Huai Chiang, Sheng-Feng Hsu, Wen-Long Hu
Patients with migraine are reportedly at increased risk of developing dementia. We aimed to investigate the association between traditional Chinese medicine (TCM) use and dementia risk in migraine patients. This longitudinal cohort study used the Taiwanese National Health Insurance Research Database to identify 32,386 diagnosed migraine patients aged 20 years and above who received treatment from 1997 to 2010. To balance comparability between TCM users and non-TCM users, we randomly selected equal numbers from each group, and compared subgroups compiled based on combinations of age, sex, index year, and year of migraine diagnosis...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723631/cbl-b-predicts-postoperative-survival-in-patients-with-resectable-pancreatic-ductal-adenocarcinoma
#17
Qian Dong, Yuteng Ma, Yao Zhang, Xiujuan Qu, Zhi Li, Yafei Qi, Yunpeng Liu, Ce Li, Kai Li, Xianghong Yang, Xiaofang Che
Casitas B-lineage lymphoma b (Cbl-b) is a ubiquitin-protein ligase and a signal transducing adaptor protein involved in immune regulation, and it may be involved in the development and progression of cancer. We investigated the association between Cbl-b expression and prognosis in patients with resectable pancreatic ductal adenocarcinoma (PDAC). The clinicopathological characteristics and survival data of 134 patients with surgery for PDAC between January 2009 and February 2012 were retrospectively evaluated, and Cbl-b expression was assayed by immunohistochemical staining...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723627/evaluation-of-hepatectomy-and-palliative-local-treatments-for-gastric-cancer-patients-with-liver-metastases-a-propensity-score-matching-analysis
#18
Jiyang Li, Kecheng Zhang, Yunhe Gao, Hongqing Xi, Jianxin Cui, Wenquan Liang, Aizhen Cai, Bo Wei, Lin Chen
BACKGROUND: The optimal treatments for gastric cancer with liver metastases (GCLM) remain controversial. This study aimed to evaluate the efficacy of hepatectomy, RFA and TACE as local treatments for GCLM. METHODS: From 2001 to 2015, 119 consecutive patients who received multidisciplinary treatments based on curative gastrectomy and local treatments (hepatectomy, RFA and TACE) for liver metastases were enrolled in this retrospective cohort study. Patients were divided into Group A (46, hepatectomy) and Group B (73, either or both RFA and TACE)...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723591/molecular-characterization-and-expression-analysis-of-the-myostatin-gene-and-its-association-with-growth-traits-in-noble-scallop-chlamys-nobilis
#19
Sigang Fan, Youhou Xu, Baosuo Liu, Wenyao He, Bo Zhang, Jiaqi Su, Dahui Yu
Myostatin (MSTN), also called growth and differentiation factor-8 (GDF-8), is a member of the transforming growth factor-β (TGF-β) superfamily and an inhibitor of muscle differentiation and growth. In this report, we identified and characterized a MSTN gene (CnMSTN) from the scallop Chlamys nobilis. The open reading frame of CnMSTN was 1374bp in length, encoding 457 amino acids. The structure of CnMSTN included a putative signal peptide, a TGF-β propeptide domain, and a conserved TGF-β domain. Phylogenetic analysis showed that the CnMSTN gene was clustered in the same subgroup with the MSTN gene found in Mollusca...
July 16, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28723519/individual-patient-data-analysis-of-randomized-clinical-trials-impact-of-black-race-on-castration-resistant-prostate-cancer-outcomes
#20
Daniel E Spratt, Yu-Wei Chen, Brandon A Mahal, Joseph R Osborne, Shuang G Zhao, Todd M Morgan, Ganesh Palapattu, Felix Y Feng, Paul L Nguyen
BACKGROUND: Population data suggest that black men have a higher risk of dying from prostate cancer (PCa) than other racial ethnicities. OBJECTIVE: To examine the impact of black race on progression-free survival (PFS) and overall survival (OS) among men with metastatic castration-resistant PCa (mCRPC) enrolled in randomized controlled trials (RCTs). DESIGN, SETTING, AND PARTICIPANTS: A pooled analysis was performed on individual patient data from five modern PCa RCTs available from Project Data Sphere...
December 2016: European Urology Focus
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