keyword
MENU ▼
Read by QxMD icon Read
search

Subgroups

keyword
https://www.readbyqxmd.com/read/29793135/accuracy-of-magnetic-resonance-venography-in-diagnosing-cerebral-venous-sinus-thrombosis
#1
Liansheng Gao, Weilin Xu, Tao Li, Xiaobo Yu, Shenglong Cao, Hangzhe Xu, Feng Yan, Gao Chen
OBJECTIVES: The non-specific clinical manifestations and lack of effective diagnostic techniques have made cerebral venous sinus thrombosis (CVST) difficult to recognize and easy to misdiagnose. Several studies have suggested that different types of magnetic resonance venography (MRV) have advantages in diagnosing CVST. We conducted this meta-analysis to assess the accuracy of MRV in identifying CVST. MATERIAL AND METHODS: We searched the Embase, PubMed, and Chinese Biomedical (CBM) databases comprehensively to retrieve eligible articles up to Mar 31, 2018...
May 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29793063/progressive-right-ventricular-enlargement-due-to-pulmonary-regurgitation-clinical-characteristics-of-a-low-risk-group
#2
Majd A El-Harasis, Heidi M Connolly, William R Miranda, Muhammad Y Qureshi, Nandini Sharma, Mohamad Al-Otaibi, Christopher V DeSimone, Alexander Egbe
BACKGROUND: The optimal interval between serial cardiac magnetic resonance imaging (CMRI) scans for monitoring right ventricular (RV) enlargement in the setting of severe pulmonic valve regurgitation (PR) is unknown. The purposes of this study were to (1) determine the annual change in RV volume on serial CMRI scans and (2) identify the risk factors for rapid progression of RV enlargement. METHODS: A retrospective study of adults with postintervention native valve PR and ≥2 CMRI scans at Mayo Clinic Rochester from 2000 to 2015 was conducted...
April 26, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29793007/minimum-clinically-important-differences-in-chronic-pain-vary-considerable-by-baseline-pain-and-methodological-factors-systematic-review-of-empirical-studies
#3
REVIEW
Mette Frahm Olsen, Eik Bjerre, Maria Damkjær Hansen, Britta Tendal, Jørgen Hilden, Asbjørn Hróbjartsson
BACKGROUND: The minimum clinically important difference (MCID) is used to interpret the relevance of treatment effects, e.g. when developing clinical guidelines, evaluating trial results or planning sample sizes. There is currently no agreement on an appropriate MCID in chronic pain and little is known about which contextual factors cause variation. METHODS: Systematic review. We searched PubMed, EMBASE and Cochrane Library. Eligible studies determined MCID for chronic pain based on a one-dimensional pain scale, a patient-reported transition scale of perceived improvement; and either a mean change analysis (mean difference in pain among minimally improved patients) or a threshold analysis (pain reduction associated with best sensitivity and specificity for identifying minimally improved patients)...
May 21, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29792881/the-temporal-association-of-robotic-surgical-diffusion-with-overtreatment-of-the-small-renal-mass
#4
Paras H Shah, Manaf A Alom, Bradley C Leibovich, R Houston Thompson, Robert G Uzzo, Louis R Kavoussi, Lee Richstone, Bimal Bhindi, Elizabeth B Habermann, Vidhu Joshi, Stephen A Boorjian
PURPOSE: To evaluate contemporary practice patterns in the management of small renal masses. METHODS: We identified 52,804 patients within the National Cancer Database diagnosed with a small renal mass (≤4cm) between 2010-2014. Utilization trends for active surveillance, ablation, and robotic, laparoscopic, and open surgical techniques were compared among all-comers, elderly patients (≥75 years) and individuals with competing health risks (Charlson index ≥2)...
May 21, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29792370/efficacy-and-safety-of-intravenous-belimumab-in-japanese-patients-with-systemic-lupus-erythematosus-a-subgroup-analysis-of-a-phase-3-randomized-placebo-controlled-trial
#5
Yoshiya Tanaka, Damon Bass, Myron Chu, Sally Egginton, Beulah Ji, Herbert Struemper, David Roth
OBJECTIVES: To assess the efficacy and safety of intravenous belimumab plus standard systemic lupus erythematosus (SLE) therapy (SoC) in Japanese patients with SLE. METHODS: A Phase 3, multicenter, double-blind, placebo-controlled, 52-week study (BEL 113750; NCT01345253) in patients with SLE, randomized 2:1 to belimumab 10 mg/kg plus SoC or placebo plus SoC to Week 48. RESULTS: Sixty of 707 randomized patients were enrolled from study centers in Japan (belimumab, n = 39; placebo, n = 21)...
May 24, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29792168/trends-in-the-incidence-and-associated-factors-of-late-onset-sepsis-associated-with-improved-survival-in-extremely-preterm-infants-born-at-23-26-weeks-gestation-a-retrospective-study
#6
Jin Kyu Kim, Yun Sil Chang, Sein Sung, So Yoon Ahn, Won Soon Park
BACKGROUND: To investigate the trends in the incidence and associated factors of late-onset sepsis (LOS) associated with improved survival in extremely preterm infants. METHODS: Medical records of 364 infants who were born at 23-26 weeks' gestation from 2000 to 2005 (period I, n = 124) and from 2006 to 2011 (period II, n = 240) were retrospectively reviewed. The infants were stratified into subgroups of 23-24 and 25-26 weeks' gestation within each period, and survival, LOS rate, and clinical characteristics were analyzed...
May 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29792098/p-wave-and-qt-dispersion-in-hypertensive-disorders-of-pregnancy
#7
Burcu Dincgez Cakmak, Betul Dundar, Fatma Ketencİ Gencer, Ulku Turker, Selçuk Kanat
AIM: To compare P-wave and QT dispersion values in hypertensive disorders of pregnancy and controls and also in preeclampsia, chronic hypertension and gestational hipertansion separately. MATERIAL AND METHODS: We included 140 hypertensive pregnants and 110 healthy age-matched pregnants in this study. The hypertensive pregnants were divided into three subgroups as preeclampsia (n = 43), chronic hypertension (n = 51) and gestational hypertension (n = 46). P-wave and QT dispersion values were compared between groups...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29792050/risk-of-psychosis-in-recurrent-episodes-of-psychotic-and-nonpsychotic-major-depressive-disorder-a-systematic-review-and-meta-analysis
#8
J Craig Nelson, David Bickford, Kevin Delucchi, Jess G Fiedorowicz, William H Coryell
OBJECTIVE: The authors conducted a systematic review and meta-analysis to determine whether the risk of psychosis is higher in past or future episodes in patients with major depression with psychotic features than in patients with nonpsychotic depression. METHOD: PubMed, Embase, and PsycINFO were searched, and studies were selected that 1) identified patients with unipolar major depression, 2) made diagnoses of psychosis based on the presence of delusions or hallucinations, 3) characterized past or subsequent episodes as psychotic or nonpsychotic, and 4) were published in English...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29791922/p2y12-polymorphisms-and-the-risk-of-adverse-clinical-events-in-patients-treated-with-clopidogrel-a-meta-analysis
#9
Kun Zhao, Ming Yang, Yanxia Lu, Shusen Sun, Wei Li, Xingang Li, Zhigang Zhao
BACKGROUND AND STUDY AIM: Some studies have reported an association between P2Y12 gene polymorphisms and clopidogrel adverse outcomes with inconsistent results. We aimed to explore the relationship between P2Y12 polymorphisms and the risk of adverse clinical events in patients treated with clopidogrel through a meta-analysis. METHODS: A systematic search of PubMed, Web of Science and the Cochrane Library was conducted. Retrieved articles were comprehensively reviewed and eligible studies were included, and the relevant data was extracted for this meta-analysis...
May 23, 2018: Drug Research
https://www.readbyqxmd.com/read/29791793/assays-for-nucleotide-competitive-reversible-and-irreversible-inhibitors-of-ras-gtpases
#10
Sadasivam Jeganathan, Matthias Philipp Müller, Ali Imtiaz, Roger S Goody
Although the Ras protein has been seen as a potential target for cancer therapy for the past 30 years, there was a tendency to consider it undruggable until recently. This has changed with the demonstration that small molecules with specifcity for (disease related mutants of) Ras can indeed be found, and some of these molecules form covalent adducts. A subgroup of these molecules can be characterized as competing with binding of the natural ligands GTP and GDP. Because of the distinct properties of Ras and related GTPases, in particular the very high nucleotide affinities and associated very low dissociation rates, assays for characterizing such molecules are not trivial...
May 23, 2018: Biochemistry
https://www.readbyqxmd.com/read/29791620/intervention-time-until-discharge-for-newborns-on-transition-from-gavage-to-exclusive-oral-feeding
#11
Andréa Monteiro Correia Medeiros, Blenda Karen Batista Ramos, Déborah Letticia Santana Santos Bomfim, Conceição Lima Alvelos, Talita Cardoso da Silva, Ikaro Daniel de Carvalho Barreto, Felipe Batista Santos, Ricardo Queiroz Gurgel
Purpose Measure the intervention time required for transition from gavage to exclusive oral feeding, comparing newborns exposed exclusively to the mother's breast with those who, in addition to breastfeeding, received supplementation using a cup or baby bottle. Methods Analytical, longitudinal, cohort study conducted with 165 newborns (NB) divided into groups according to severity of medical complications (G1-with no complications; G2-with significant complications), and into subgroups according to feeding mechanism (A and B)...
2018: CoDAS
https://www.readbyqxmd.com/read/29791437/a-randomized-controlled-trial-on-the-effect-of-a-silver-carboxymethylcellulose-dressing-on-surgical-site-infections-after-breast-cancer-surgery
#12
Gerson M Struik, Wietske W Vrijland, Erwin Birnie, Taco M A L Klem
BACKGROUND: The incidence of surgical site infections (SSIs) after breast cancer surgery is relatively high; ranging from 3 to 19%. The role of wound dressings in the prevention of SSI after breast cancer surgery is unclear. This study compares a silver carboxymethylcellulose dressing (AQUACEL Ag Surgical (Aquacel) with standard wound dressing in SSI rate after breast cancer surgery. PATIENTS AND METHODS: A single-centre randomized controlled trial among women ≥18 years, diagnosed with breast cancer, undergoing breast conserving or ablative surgery, was conducted in a combined in and outpatient setting...
2018: PloS One
https://www.readbyqxmd.com/read/29791303/the-timing-of-suicide-in-18-united-state-states-from-2003-2014
#13
Niu Tian, Matthew Zack, Katherine A Fowler, Dale C Hesdorffer
OBJECTIVES: We investigated suicide timing over different time periods by age, sex and race/ethnicity. METHODS: 122,107 suicide deaths were identified from the population-based U.S. National Violent Death Reporting System in 18 U.S. States from 2003 through 2014. RESULTS: Suicides significantly increased (p < 0.05) from March to peak in September before falling, the first week of the month, and early in the week. Suicides also significantly increased (p < 0...
May 23, 2018: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/29791023/comparison-of-the-cockcroft-gault-mdrd-and-ckd-epi-equations-for-estimating-ganciclovir-clearance
#14
Maria-Eugenia Palacio-Lacambra, Immaculada Comas-Reixach, Albert Blanco-Grau, Josep-Maria Suñé-Negre, Alfonso Segarra-Medrano, José-Bruno Montoro-Ronsano
BACKGROUND: Accurately estimating kidney function is essential for the safe administration of renally cleared drugs like ganciclovir. Current practice recommends adjusting renally eliminated drugs according to the Cockcroft-Gault equation. There is no data on the utility of the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in ganciclovir dosing. PURPOSE: To evaluate which renal function equation best predicts ganciclovir clearance...
May 23, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29791007/should-all-patients-with-adrenal-insufficiency-or-a-subgroup-of-patients-with-pre-diabetes-be-treated-with-dual-release-hydrocortisone
#15
Roberta Giordano
Guarnotta et al. compare the effects of dual-release (DR) hydrocortisone 36 months' treatment in 13 patients with primary adrenal insufficiency and 36 with secondary adrenal insufficiency, compared to conventional glucocorticoid treatment. A retrospective evaluation was conducted on the effects of 36 months of DR hydrocortisone therapy on visceral adiposity, insulin secretion and insulin sensitivity. Forty-nine patients with adrenal insufficiency were recruited. This article is protected by copyright. All rights reserved...
May 23, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29790926/bathyarchaeota-globally-distributed-metabolic-generalists-in-anoxic-environments
#16
Zhichao Zhou, Jie Pan, Fengping Wang, Ji-Dong Gu, Meng Li
Bathyarchaeota, formerly known as the Miscellaneous Crenarchaeotal Group, is a phylum of global generalists that are widespread in anoxic sediments, which host relatively high abundant archaeal communities. Until now, 25 subgroups have been identified in the Bathyarchaeota. The distinct bathyarchaeotal subgroups diverged to adapt to the marine and freshwater environments. Based on the physiological and genomic evidence, acetyl-CoA centralized heterotrophic pathways of energy conservation have been proposed to function in Bathyarchaeota; these microbes are able to anaerobically utilize (i) detrital proteins, (ii) polymeric carbohydrates, (iii) fatty acids/aromatic compounds, (iv) methane (or short chain alkane) and methylated compounds, (v) and/or potentially other organic matter...
May 21, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29790788/no-association-of-moon-phase-with-stroke-occurrence
#17
Jori O Ruuskanen, Jussi O T Sipilä, Päivi Rautava, Ville Kytö
Stroke occurrence shows strong correlations with sleep disorders and even subtle sleep disturbances have been shown to affect ischemic stroke (IS) occurrence. Chronobiology also exerts effects, like the morning surge in IS occurrence. Lunar cycles have also been shown to affect sleep and other physiological processes, but studies on moon phases and its possible association with occurrence of stroke are rare and nonconclusive. Therefore, we studied the effects of moon phases on stroke hospitalizations and in-hospital mortality nationwide in Finland in 2004-2014...
May 23, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29790680/spirometry-testing-among-the-homeless
#18
Jerzy Romaszko, Adam Buciński, Anna M Romaszko, Anna Doboszyńska
BACKGROUND: Many literature reports have indicated the fact that the percentage of active smokers among the homeless is high, often several times higher than that of the general population. The homeless are known to have worse spirometric parameters than the general population. OBJECTIVES: The question of what the principal and exclusive cause of airway obstruction among the homeless is remains unanswered. Verification of the above-mentioned hypothesis is possible by comparing the spirometric parameters in homeless people with those in the general population, based on the data related to subgroups with similar tobacco smoke exposure, which are homogenous in terms of sex, race and age...
April 18, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790666/rolapitant-for-the-prevention-of-nausea-in-patients-receiving-highly-or-moderately-emetogenic-chemotherapy
#19
Rudolph M Navari, Bernardo L Rapoport, Dan Powers, Sujata Arora, Rebecca Clark-Snow
Most patients receiving highly or moderately emetogenic chemotherapy experience chemotherapy-induced nausea and vomiting without antiemetic prophylaxis. While neurokinin-1 receptor antagonists (NK-1RAs) effectively prevent emesis, their ability to prevent nausea has not been established. We evaluated the efficacy of the long-acting NK-1RA rolapitant in preventing chemotherapy-induced nausea using post hoc analyses of data from 3 phase 3 trials. Patients were randomized to receive 180 mg oral rolapitant or placebo approximately 1-2 hours before chemotherapy in combination with a 5-hydroxytryptamine type 3 RA and dexamethasone...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29790628/metabolic-syndrome-and-its-components-are-associated-with-increased-chronic-kidney-disease-risk-evidence-from-a-meta-analysis-on-11-109-003-participants-from-66-studies
#20
Shahab Alizadeh, Mahsa Ahmadi, Behnam Ghorbani Nejad, Abolghassem Djazayeri, Sakineh Shab-Bidar
BACKGROUND & AIMS: Observational studies examining the relationship between metabolic syndrome and the risk of chronic kidney disease (CKD) have reported inconclusive results. This meta-analysis was performed to resolve these controversies. METHODS: The MEDLINE, EMBASE, and PubMed databases were systematically searched from their inception until March 2016 to identify all relevant studies. Risk estimates and their corresponding 95% confidence intervals (CIs) for the associations of MetS and its components with CKD risk were extracted and pooled using a random-effects model...
May 23, 2018: International Journal of Clinical Practice
keyword
keyword
100908
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"