keyword
MENU ▼
Read by QxMD icon Read
search

Diabetic neuropathy pain

keyword
https://www.readbyqxmd.com/read/28928602/lncrna-nonratt021972-was-associated-with-neuropathic-pain-scoring-in-patients-with-type-2-diabetes
#1
Wei Yu, Guo-Qing Zhao, Rang-Juan Cao, Zhi-Hua Zhu, Kai Li
BACKGROUND: Long noncoding RNAs were involved in the processes of diabetes. Our study was aimed to explore clinical potential of LncRNA NONRATT021972 in diabetic neuropathic pain and investigate detailed mechanisms. METHODS: 154 patients with type 2 diabetes were enrolled as experimental group paired with control. Patients without diabetes but neuropathy were enrolled to explore exclusive role of LncRNA NONRATT021972 in neuropathy. Real-time PCR and ELISA were performed to examine expression of LncRNA and TNF-α in flood...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28925511/morphine-hyposensitivity-in-stz-diabetic-rats-reversal-by-dietary-l-arginine-treatment
#2
Shahrdad Lotfipour, Maree T Smith
Painful diabetic neuropathy (PDN) is a long-term complication of diabetes. Defining symptoms include mechanical allodynia (pain due to light pressure or touch) and morphine hyposensitivity. In our previous work using the streptozotocin (STZ)-diabetic rat model of PDN, morphine hyposensitivity developed in a temporal manner with efficacy abolished at 3-months post-STZ and maintained for 6-months post-STZ. As this time course mimicked that for the temporal development of hyposensitivity to the pain-relieving effects of the furoxan nitric oxide (NO) donor, PRG150 (3-methylfuroxan-4-carbaldehyde) in STZ-diabetic rats, we hypothesized that progressive depletion of endogenous NO bioactivity may underpin the temporal loss of morphine sensitivity in STZ-diabetic rats...
September 19, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28915983/single-treatment-with-capsaicin-8-patch-may-reduce-pain-and-sleep-interference-up-to-12-weeks-in-patients-with-painful-diabetic-peripheral-neuropathy
#3
Daniel A Ostrovsky
No abstract text is available yet for this article.
September 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28900459/protective-effects-of-bogijetong-decoction-and-its-selected-formula-on-neuropathic-insults-in-streptozotocin-induced-diabetic-animals
#4
Ki-Joong Kim, Uk Namgung, Chung Sik Cho
Bogijetong decoction (BGJTD) is a mixture of herbal formulation which is used in the traditional Korean medicine for the treatment of neuropathic pain caused by diabetes. Here, we investigated the regulatory effects of BGJTD and its reconstituted decoction subgroups on the neuropathic responses in streptozotocin- (STZ-) induced diabetic animals. Be decoction (BeD) was formulated by selecting individual herbal components that induced neurite outgrowth most efficiently in each subgroup. BeD induced the neurite outgrowth in DRG neurons most efficiently among decoction subgroups and downregulated the production of TNF-α from the sciatic nerves in STZ-diabetic animals...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28877402/effects-of-s-38093-an-antagonist-inverse-agonist-of-histamine-h3-receptors-in-models-of-neuropathic-pain-in-rats
#5
T Chaumette, E Chapuy, E Berrocoso, M Llorca-Torralba, L Bravo, J A Mico, M Chalus, A Eschalier, D Ardid, F Marchand, A Sors
BACKGROUND: Histamine H3 receptors are mainly expressed on CNS neurons, particularly along the nociceptive pathways. The potential involvement of these receptors in pain processing has been suggested using H3 receptor inverse agonists. METHODS: The antinociceptive effect of S 38093, a novel inverse agonist of H3 receptors, has been evaluated in several neuropathic pain models in rat and compared with those of gabapentin and pregabalin. RESULTS: While S 38093 did not change vocalization thresholds to paw pressure in healthy rats, it exhibited a significant antihyperalgesic effect in the Streptozocin-induced diabetic (STZ) neuropathy model after acute and chronic administration and, in the chronic constriction injury (CCI) model only after chronic administration, submitted to the paw-pressure test...
September 6, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28873075/intraoperative-magnesium-sulphate-decreases-agitation-and-pain-in-patients-undergoing-functional-endoscopic-surgery-a-randomised-double-blind-study
#6
Hazem E Elsersy, Magdy Ch Metyas, Hana A Elfeky, Ahmed A Hassan
BACKGROUND: Postoperative agitation is harmful for the patient as it may be associated with removal of catheters, nasal packs, oxygen masks and self-injury, and pose a danger to operating theatre staff. OBJECTIVE: The current study investigated the potential role of magnesium sulphate in treatment of postoperative agitation following functional endoscopic sinus surgery. DESIGN: A randomised, double-blinded, placebo-controlled trial. SETTING: ENT operating room, Menofia University Hospitals, Egypt...
October 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28858986/sensory-phenotype-and-risk-factors-for-painful-diabetic-neuropathy-a-cross-sectional-observational-study
#7
Jana Raputova, Iva Srotova, Eva Vlckova, Claudia Sommer, Nurcan Uceyler, Frank Birklein, Heike L Rittner, Cora Rebhorn, Blanka Adamova, Ivana Kovalova, Eva Kralickova Nekvapilova, Lucas Forer, Jana Belobradkova, Jindrich Olsovsky, Pavel Weber, Ladislav Dusek, Jiri Jarkovsky, Josef Bednarik
Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined DSPN subjects.This observational cross-sectional multi-center cohort study (performed as part of the ncRNAPain EU consortium) of 232 subjects with non-painful (n=74) and painful (n=158) DSPN associated with diabetes mellitus of type 1 and 2 (median age 63 years, range 21-87 years; 92 women) comprised detailed history taking, laboratory tests, neurological examination, quantitative sensory testing, nerve conduction studies, and neuropathy severity scores...
August 3, 2017: Pain
https://www.readbyqxmd.com/read/28858146/the-relationship-between-peripheral-artery-disease-symptomatology-and-ischemia
#8
Erica N Schorr, Diane Treat-Jacobson, Ruth Lindquist
BACKGROUND: Fewer than half of individuals with peripheral artery disease (PAD) experience classic claudication, and the relationships between PAD typical or atypical symptom intensity, location, and description (classic or atypical) with ischemic changes have not previously been reported. OBJECTIVE: The primary purpose of this study was to evaluate the relationship between self-reported PAD symptom intensity and calf tissue ischemia measured using the tissue saturation index (TSI) during treadmill exercise...
September 2017: Nursing Research
https://www.readbyqxmd.com/read/28855790/safety-of-lower-extremity-neurodynamic-exercises-in-adults-with-diabetes-mellitus-a-feasibility-study
#9
Benjamin S Boyd, Robert J Nee, Betty Smoot
OBJECTIVES: Neurodynamic exercises aim to improve neural mechanosensitivity in order to promote pain-free movement and function. People with diabetes mellitus (DM) may be candidates for neurodynamic exercises to address common DM-related impairments such as reduced lower extremity range of motion (ROM) and altered neural mechanosensitivity. However, no studies have examined the safety and immediate effects of neurodynamic exercise in people with DM. This study aims to determine the feasibility of applying neurodynamic exercises in adults with DM by evaluating the rate of adverse events and quantifying immediate changes in straight leg raise (SLR) ROM...
February 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28851944/therapeutic-effect-of-human-adipose-derived-stem-cells-and-their-secretome-in-experimental-diabetic-pain
#10
Anna T Brini, Giada Amodeo, Lorena M Ferreira, Anna Milani, Stefania Niada, Giorgia Moschetti, Silvia Franchi, Elisa Borsani, Luigi F Rodella, Alberto E Panerai, Paola Sacerdote
Painful neuropathy is one of the complications of diabetes mellitus that adversely affects patients'quality of life. Pharmacological treatments are not fully satisfactory, and novel approaches needed. In a preclinical mouse model of diabetes the effect of both human mesenchymal stromal cells from adipose tissue (hASC) and their conditioned medium (hASC-CM) was evaluated. Diabetes was induced by streptozotocin. After neuropathic hypersensitivity was established, mice were intravenously injected with either 1 × 10(6) hASC or with CM derived from 2 × 10(6) hASC...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28841868/a-systematic-review-of-the-effectiveness-of-policies-restricting-access-to-pregabalin
#11
Brett R Stacey, Jonathan Liss, Regina Behar, Alesia Sadosky, Bruce Parsons, Elizabeth T Masters, Patrick Hlavacek
BACKGROUND: Formularies often employ restriction policies to reduce pharmacy costs. Pregabalin, an alpha-2-delta ligand, is approved for treatment of fibromyalgia (FM); neuropathic pain (NeP) due to postherpetic neuralgia (PHN), diabetic peripheral neuropathy (pDPN), spinal cord injury; and as adjunct therapy for partial onset seizures. Pregabalin is endorsed as first-line therapy for these indications by several US and EU medical professional societies. However, restriction policies such as prior authorization (PA) and step therapy (ST) often favor less costly generic pain medications over pregabalin...
August 25, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28840511/nanoparticle-encapsulated-emodin-decreases-diabetic-neuropathic-pain-probably-via-a-mechanism-involving-p2x3-receptor-in-the-dorsal-root-ganglia
#12
Lin Li, Xuan Sheng, Shanhong Zhao, Lifang Zou, Xinyao Han, Yingxin Gong, Huilong Yuan, Liran Shi, Lili Guo, Tianyu Jia, Shuangmei Liu, Bing Wu, Zhihua Yi, Hui Liu, Yun Gao, Guilin Li, Guodong Li, Chunping Zhang, Hong Xu, Shangdong Liang
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). More than 90% of all cases of DM belong to type 2 diabetes mellitus (T2DM). Emodin is the main active component of Radix et rhizoma rhei and has anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. Nanoparticle encapsulation of drugs is beneficial for drug targeting and bioavailability as well as for lowering drug toxicity side effects. The aim of this study was to investigate the effects of nanoparticle-encapsulated emodin (nano emodin) on diabetic neuropathic pain (DNP) mediated by the Purin 2X3 (P2X3) receptor in the dorsal root ganglia (DRG)...
August 24, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28837503/therapeutic-potential-for-leukocyte-elastase-in-chronic-pain-states-harboring-a-neuropathic-component
#13
Kiran Kumar Bali, Rohini Kuner
Neuropathic pain is an integral component of several chronic pain conditions and poses a major health problem worldwide. Despite emerging understanding of mechanisms behind neuropathic pain, the available treatment options are still limited in efficacy or associated with side effects, therefore making it necessary to find viable alternatives. In a genetic screen, we recently identified SerpinA3N, a serine protease inhibitor secreted in response to nerve damage by the DRG neurons and we showed that SerpinA3N acts against induction of neuropathic pain by inhibiting the T-cell- and neutrophil-derived protease, leucocyte elastase (LE)...
August 19, 2017: Pain
https://www.readbyqxmd.com/read/28837075/botulinum-toxin-for-the-treatment-of-neuropathic-pain
#14
REVIEW
JungHyun Park, Hue Jung Park
Botulinum toxin (BoNT) has been used as a treatment for excessive muscle stiffness, spasticity, and dystonia. BoNT for approximately 40 years, and has recently been used to treat various types of neuropathic pain. The mechanism by which BoNT acts on neuropathic pain involves inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerves. Recent journals have demonstrated that BoNT is effective for neuropathic pain, such as postherpetic neuralgia, trigeminal neuralgia, and peripheral neuralgia...
August 24, 2017: Toxins
https://www.readbyqxmd.com/read/28827482/insulin-neuritis-and-effect-of-pregabalin
#15
Yasser Aladdin, Thomas Jeerakathil, Zaeem A Siddiqi
INTRODUCTION: Insulin neuritis (IN) is a rare condition that results in acute painful neuropathy. It occurs classically in patients with diabetes mellitus with uncontrolled sugar levels who are started on insulin therapy leading to a precipitous normalization of blood sugar levels. The condition is heralded by severe and generalized burning pain along with significant weight loss and mood issues. The diagnosis is mainly clinical and the etiology of IN remains obscure. METHODS AND RESULTS: We report on 2 cases who developed acute and excruciating neuropathic pain after institution of insulin therapy for poorly controlled diabetes mellitus...
September 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28827464/pharmacotherapy-for-diabetic-peripheral-neuropathy-pain-and-quality-of-life-a-systematic-review
#16
(no author information available yet)
No abstract text is available yet for this article.
August 22, 2017: Neurology
https://www.readbyqxmd.com/read/28819738/high-dose-8-capsaicin-patch-in-treatment-of-chemotherapy-induced-peripheral-neuropathy-single-center-experience
#17
Iwona Filipczak-Bryniarska, Roger M Krzyzewski, Jakub Kucharz, Anna Michalowska-Kaczmarczyk, Justyna Kleja, Jarosław Woron, Katarzyna Strzepek, Lucyna Kazior, Jerzy Wordliczek, Tomasz Grodzicki, Krzysztof Krzemieniecki
High-dose capsaicin patch is effective in treatment of neuropathic pain in HIV-associated neuropathy and diabetic neuropathy. There are no studies assessing effectiveness of high-dose capsaicin patch in treatment of chemotherapy-induced peripheral neuropathy. We sought to determine the effectiveness of treatment of pain associated with chemotherapy-induced peripheral neuropathy with high-dose capsaicin patch. Our study group consisted of 18 patients with clinically confirmed oxaliplatin-induced neuropathy. Baseline characteristic including underling disease, received cumulative dose of neurotoxic agent, neuropathic symptoms, prior treatment and initial pain level were recorded...
August 17, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28814157/the-role-and-mechanism-of-glutamic-nmda-receptor-in-the-mechanical-hyperalgesia-in-diabetic-rats
#18
Jin Wang, Zhaohui Sun, Yuzhao Wang, Huisheng Wang, Yuan Guo
OBJECTIVES: Some studies have shown that painful neuropathy is a common and costly complication of both type 1 and type 2 diabetes mellitus, and glutamate is involved in the process although the mechanisms are not clear. The purpose of the present study was to investigate the effect of N-methyl-D-aspartate (NMDA) receptor on mechanical hyperalgesia in diabetic rats and the possible mechanism. METHODS: Diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ, 1%, 70 mg/kg) once, and evaluated by the change in the fasting blood glucose...
August 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28813083/ankle-brachial-index-and-diabetic-neuropathy-study-of-225-patients
#19
Liliana Chevtchouk, Marcio Heitor Stelmo da Silva, Osvaldo José Moreira do Nascimento
Objective: To evaluate neuropathic pain and peripheral vascular disease in diabetics and compare this with the length of time since diagnosis in type 1, and type 2 diabetes. Methods: A cross-sectional study with 225 diabetics chosen from their responses on the DN4 questionnaire, who were then evaluated with the ankle-brachial index (ABI), separating type 1 diabetes from type 2 diabetes. Results: A higher incidence of neuropathic pain in those over 60 years of age showed an ABI > 1...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28794656/neuropathic-pain-responds-better-to-increased-doses-of-pregabalin-an-in-depth-analysis-of-flexible-dose-clinical-trials
#20
Michael Serpell, Mark Latymer, Mary Almas, Marie Ortiz, Bruce Parsons, Rita Prieto
BACKGROUND: Pregabalin is an effective treatment option for many patients with neuropathic pain. Higher doses of pregabalin have been shown to be more effective in improving pain outcomes but, in practice, failing to appropriately increase the dose can leave patients under-treated. METHODS: This was a pooled analysis of 6 flexible-dose clinical trials of pregabalin in patients with neuropathic pain (diabetic peripheral neuropathy, peripheral herpetic neuralgia, posttraumatic pain, or postsurgical pain)...
2017: Journal of Pain Research
keyword
keyword
100907
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"