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https://www.readbyqxmd.com/read/27910645/publisher-s-note-gaseous-electron-multiplier-based-soft-x-ray-plasma-diagnostics-development-preliminary-tests-at-asdex-upgrade-rev-sci-instrum-87-11e325-2016
#1
M Chernyshova, K Malinowski, T Czarski, A Wojeński, D Vezinet, K T Poźniak, G Kasprowicz, D Mazon, A Jardin, A Herrmann, E Kowalska-Strzęciwilk, R Krawczyk, P Kolasiński, W Zabołotny, P Zienkiewicz
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910468/gaseous-electron-multiplier-based-soft-x-ray-plasma-diagnostics-development-preliminary-tests-at-asdex-upgrade
#2
M Chernyshova, K Malinowski, T Czarski, A Wojeński, D Vezinet, K T Poźniak, G Kasprowicz, D Mazon, A Jardin, A Herrmann, E Kowalska-Strzęciwilk, R Krawczyk, P Kolasiński, W Zabołotny, P Zienkiewicz
A Gaseous Electron Multiplier (GEM)-based detector is being developed for soft X-ray diagnostics on tokamaks. Its main goal is to facilitate transport studies of impurities like tungsten. Such studies are very relevant to ITER, where the excessive accumulation of impurities in the plasma core should be avoided. This contribution provides details of the preliminary tests at ASDEX Upgrade (AUG) with a focus on the most important aspects for detector operation in harsh radiation environment. It was shown that both spatially and spectrally resolved data could be collected, in a reasonable agreement with other AUG diagnostics...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27907036/the-characteristic-of-s100a7-induction-by-the-hippo-yap-pathway-in-cervical-and-glossopharyngeal-squamous-cell-carcinoma
#3
Fei Kong, Yunguang Li, Enze Hu, Rui Wang, Junhao Wang, Jin Liu, Jinsan Zhang, Dacheng He, Xueyuan Xiao
S100A7 is expressed in many squamous cell carcinomas (SCCs). Our previous study revealed that S100A7 was dramatically induced in several SCC cells and activation of the Hippo pathway significantly promoted S100A7 in epidermoid carcinoma cells. However, whether the Hippo pathway regulates S100A7 expression in SCCs remains largely unknown. Here, we uncover that S100A7 induction by the Hippo-YAP pathway displays different characteristic in cervical and glossopharyngeal SCC. In well differentiated HCC94 cervical cells and FaDu pharyngeal cells, S100A7 is easily induced by both suspension and dense culture, which is accompanied by an increase in YAP phosphorylation and a decrease in nuclear YAP...
2016: PloS One
https://www.readbyqxmd.com/read/27883091/mycobacterium-tuberculosis-triggered-hippo-pathway-orchestrates-cxcl1-2-expression-to-modulate-host-immune-responses
#4
Monoranjan Boro, Vikas Singh, Kithiganahalli Narayanaswamy Balaji
Mycobacterium tuberculosis (Mtb) pathogenesis encompasses a plethora of finely regulated alterations within the host which eventually coin the outcome of infection. Chemokines are important components in directing immune cell recruitment to the site of infection, and shaping the disease progression. Here, we demonstrate that Hippo (mammalian sterile 20-like 1 and 2 kinases, MST1/2, in mammals), is activated during mycobacterial infection in a toll-like receptor (TLR) 2-interleukin receptor-1 associated kinases (IRAK1/4)-dependent manner...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27881216/interacting-network-of-hippo-wnt-%C3%AE-catenin-and-notch-signaling-represses-liver-tumor-formation
#5
Wantae Kim, Sanjoy Kumar Khan, Yingzi Yang
Acquiring a selective growth advantage by breaking the proliferation barrier established by gatekeeper genes is a centrally important event in tumor formation. Removal of mammalian Hippo kinase Mst1 and Mst2 in hepatocytes leads to very rapid hepatocellular carcinoma (HCC) formation, indicating that the Hippo signaling pathway is a critical gatekeeper in hepatocytes that restrains abnormal growth. By rigorous genetic approaches, we have identified an interacting network of the Hippo, Wnt/β-catenin and Notch signaling pathways that controls organ size and HCC development...
November 24, 2016: BMB Reports
https://www.readbyqxmd.com/read/27869648/hippo-signaling-interactions-with-wnt-%C3%AE-catenin-and-notch-signaling-repress-liver-tumorigenesis
#6
Wantae Kim, Sanjoy Kumar Khan, Jelena Gvozdenovic-Jeremic, Youngeun Kim, Jason Dahlman, Hanjun Kim, Ogyi Park, Tohru Ishitani, Eek-Hoon Jho, Bin Gao, Yingzi Yang
Malignant tumors develop through multiple steps of initiation and progression, and tumor initiation is of singular importance in tumor prevention, diagnosis, and treatment. However, the molecular mechanism whereby a signaling network of interacting pathways restrains proliferation in normal cells and prevents tumor initiation is still poorly understood. Here, we have reported that the Hippo, Wnt/β-catenin, and Notch pathways form an interacting network to maintain liver size and suppress hepatocellular carcinoma (HCC)...
November 21, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27826870/hippo-signaling-in-mitosis-an-updated-view-in-light-of-the-men-pathway
#7
Alexander Hergovich
The Hippo pathway is an essential tumor suppressor signaling network that coordinates cell proliferation, death, and differentiation in higher eukaryotes. Intriguingly, the core components of the Hippo pathway are conserved from yeast to man, with the yeast analogs of mammalian MST1/2 (fly Hippo), MOB1 (fly Mats), LATS1/2 (fly Warts), and NDR1/2 (fly Tricornered) functioning as essential components of the mitotic exit network (MEN). Here, we update our previous summary of mitotic functions of Hippo core components in Drosophila melanogaster and mammals, with particular emphasis on similarities between the yeast MEN pathway and mitotic Hippo signaling...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27825852/osm-mitigates-post-infarction-cardiac-remodeling-and-dysfunction-by-up-regulating-autophagy-through-mst1-suppression
#8
Jianqiang Hu, Lei Zhang, Zhijing Zhao, Mingming Zhang, Jie Lin, Jiaxing Wang, Wenjun Yu, Wanrong Man, Congye Li, Rongqing Zhang, Erhe Gao, Haichang Wang, Dongdong Sun
The incidence and prevalence of heart failure (HF) in the world are rapidly rising possibly attributed to the worsened HF following myocardial infarction (MI) in recent years. Here we examined the effects of oncostatin M (OSM) on postinfarction cardiac remodeling and the underlying mechanisms involved. MI model was induced using left anterior descending coronary artery (LAD) ligation. In addition, cultured neonatal mouse cardiomyocytes were subjected to simulated MI. Our results revealed that OSM alleviated left ventricular remodeling, promoted cardiac function, restored mitochondrial cristae density and architecture disorders after 4weeks of MI...
November 4, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27825096/phosphoinositide-3-kinase-akt-inhibits-mst1-mediated-pro-apoptotic-signaling-through-phosphorylation-of-threonine-120
#9
Zengqiang Yuan, Donghwa Kim, Shaokun Shu, Junbing Wu, Jianping Guo, Lei Xiao, Satoshi Kaneko, Domenico Coppola, Jin Q Cheng
No abstract text is available yet for this article.
October 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27793648/shikonin-regulates-c-myc-and-glut1-expression-through-the-mst1-yap1-tead1-axis
#10
Karel Vališ, Pavel Talacko, Valéria Grobárová, Jan Černý, Petr Novák
The general mechanism underlying the tumor suppressor activity of the Hippo signaling pathway remains unclear. In this study, we explore the molecular mechanisms connecting the Hippo signaling pathway with glucose metabolism. We have found that two key regulators of glycolysis, C-MYC and GLUT1, are targets of the Hippo signaling pathway in human leukemia cells. Our results revealed that activation of MST1 by the natural compound shikonin inhibited the expression of GLUT1 and C-MYC. Furthermore, RNAi experiments confirmed the regulation of GLUT1 and C-MYC expression via the MST1-YAP1-TEAD1 axis...
October 25, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27781435/detecting-beer-intake-by-unique-metabolite-patterns
#11
Gözde Gürdeniz, Morten Georg Jensen, Sebastian Meier, Lene Bech, Erik Lund, Lars Ove Dragsted
Evaluation of health related effects of beer intake is hampered by the lack of accurate tools for assessing intakes (biomarkers). Therefore, we identified plasma and urine metabolites associated with recent beer intake by untargeted metabolomics and established a characteristic metabolite pattern representing raw materials and beer production as a qualitative biomarker of beer intake. In a randomized, crossover, single-blinded meal study (MSt1) 18 participants were given one at a time four different test beverages: strong, regular and non-alcoholic beers and a soft drink...
October 26, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27765911/integrin-%C3%AE-2%C3%AE-1-inhibits-mst1-kinase-phosphorylation-and-activates-yes-associated-protein-oncogenic-signaling-in-hepatocellular-carcinoma
#12
Kwong-Fai Wong, Angela M Liu, Wanjin Hong, Zhi Xu, John M Luk
The Hippo pathway regulates the down-stream target Yes-associated protein (YAP) to maintain organ homeostasis, which is commonly inactivated in many types of cancers. However, how cell adhesion dysregulates the Hippo pathway activating YAP oncogene in hepatocellular carcinoma (HCC) remains unclear. Our findings demonstrate that α2β1 integrin (but not other β1 integrins) expressed in HCC cells, after binding to collagen extracellular matrix, could inhibit MST1 kinase phosphorylation and activate YAP pro-oncogenic activities...
October 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27746719/integrin-activation-through-the-hematopoietic-adapter-molecule-adap-regulates-dendritic-development-of-hippocampal-neurons
#13
Marlen Thiere, Stefanie Kliche, Bettina Müller, Jan Teuber, Isabell Nold, Oliver Stork
Integrin-mediated cell adhesion and signaling is of critical importance for neuronal differentiation. Recent evidence suggests that an "inside-out" activation of β1-integrin, similar to that observed in hematopoietic cells, contributes to the growth and branching of dendrites. In this study, we investigated the role of the hematopoietic adaptor protein adhesion and degranulation promoting adapter protein (ADAP) in these processes. We demonstrate the expression of ADAP in the developing and adult nervous hippocampus, and in outgrowing dendrites of primary hippocampal neurons...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27718125/expression-and-significance-of-hippo-yap-signaling-in-glioma-progression
#14
Hao Zhang, Decheng Geng, Jian Gao, Yanhua Qi, Yi Shi, Yan Wang, Yang Jiang, Yu Zhang, Jiale Fu, Yu Dong, Shangfeng Gao, Rutong Yu, Xiuping Zhou
Dysregulation of Hippo/YAP signaling leads to aberrant cell growth and neoplasia. Although the roles and regulation of Hippo/YAP signaling were extensively studied in cancer biology recently, study systematically checking the expression pattern of core components of this pathway at the tumor tissue level remains lacking. In this study, we thoroughly examined the profile of core components of Hippo/YAP signaling in patient specimens both at the mRNA and at protein levels. We found that the mRNA level of YAP1/TAZ and their target genes, CRY61, CTGF, and BIRC5, was remarkably amplified in glioma tissues...
October 7, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27716844/sarah-domain-mediated-mst2-rassf-dimeric-interactions
#15
Goar Sánchez-Sanz, Bartłomiej Tywoniuk, David Matallanas, David Romano, Lan K Nguyen, Boris N Kholodenko, Edina Rosta, Walter Kolch, Nicolae-Viorel Buchete
RASSF enzymes act as key apoptosis activators and tumor suppressors, being downregulated in many human cancers, although their exact regulatory roles remain unknown. A key downstream event in the RASSF pathway is the regulation of MST kinases, which are main effectors of RASSF-induced apoptosis. The regulation of MST1/2 includes both homo- and heterodimerization, mediated by helical SARAH domains, though the underlying molecular interaction mechanism is unclear. Here, we study the interactions between RASSF1A, RASSF5, and MST2 SARAH domains by using both atomistic molecular simulation techniques and experiments...
October 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27701149/mst1-dependent-vesicle-trafficking-regulates-neutrophil-transmigration-through-the-vascular-basement-membrane
#16
Angela R M Kurz, Monika Pruenster, Ina Rohwedder, Mahalakshmi Ramadass, Kerstin Schäfer, Ute Harrison, Gabriel Gouveia, Claudia Nussbaum, Roland Immler, Johannes R Wiessner, Andreas Margraf, Dae-Sik Lim, Barbara Walzog, Steffen Dietzel, Markus Moser, Christoph Klein, Dietmar Vestweber, Rainer Haas, Sergio D Catz, Markus Sperandio
Neutrophils need to penetrate the perivascular basement membrane for successful extravasation into inflamed tissue, but this process is incompletely understood. Recent findings have associated mammalian sterile 20-like kinase 1 (MST1) loss of function with a human primary immunodeficiency disorder, suggesting that MST1 may be involved in immune cell migration. Here, we have shown that MST1 is a critical regulator of neutrophil extravasation during inflammation. Mst1-deficient (Mst1-/-) neutrophils were unable to migrate into inflamed murine cremaster muscle venules, instead persisting between the endothelium and the basement membrane...
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27696525/melatonin-alleviates-post-infarction-cardiac-remodeling-and-dysfunction-by-inhibiting-mst1
#17
Jianqiang Hu, Lei Zhang, Yang Yang, Yanjie Guo, Yanhong Fan, Mingming Zhang, Wanrong Man, Erhe Gao, Wei Hu, Russel J Reiter, Haichang Wang, Dongdong Sun
Melatonin reportedly protects against several cardiovascular diseases including ischemia/reperfusion (I/R), atherosclerosis and hypertension. The present study investigated the effects and mechanisms of melatonin on cardiomyocyte autophagy, apoptosis and mitochondrial injury in the context of MI. We demonstrated that melatonin significantly alleviated cardiac dysfunction after MI. Four weeks after MI, echocardiography and Masson staining indicated that melatonin notably mitigated adverse left ventricle remodeling...
October 1, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27680548/mst1-inhibits-cmecs-autophagy-and-participates-in-the-development-of-diabetic-coronary-microvascular-dysfunction
#18
Jie Lin, Lei Zhang, Mingming Zhang, Jianqiang Hu, Tingting Wang, Yu Duan, Wanrong Man, Bin Wu, Jiaxu Feng, Lei Sun, Congye Li, Rongqing Zhang, Haichang Wang, Dongdong Sun
Cardiovascular complications account for a substantial proportion of morbidity and mortality in diabetic patients. Abnormalities of cardiac microvascular endothelial cells (CMECs) lead to impaired cardiac microvascular vessel integrity and subsequent cardiac dysfunction, underlining the importance of coronary microvascular dysfunction. In this study, experimental diabetes models were constructed using Mst1 transgenic, Mst1 knockout and sirt1 knockout mice. Diabetic Mst1 transgenic mice exhibited impaired cardiac microvessel integrity and decreased cardiac function...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27661120/frmd6-inhibits-human-glioblastoma-growth-and-progression-by-negatively-regulating-activity-of-receptor-tyrosine-kinases
#19
Yin Xu, Kaiqiang Wang, Qin Yu
FRMD6 is an Ezrin/Radixin/Moesin (ERM) family protein and a human homologue of Drosophila expanded (ex). Ex functions in parallel of Drosophila merlin at upstream of the Hippo signaling pathway that controls proliferation, apoptosis, tissue regeneration, and tumorigenesis. Even though the core kinase cascade (MST1/2-Lats1/2-YAP/TAZ) of the Hippo pathway has been well established, its upstream regulators are not well understood. Merlin promotes activation of the Hippo pathway. However, the effect of FRMD6 on the Hippo pathway is controversial...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27643882/rassf5-an-mst-activator-and-tumor-suppressor-in-vivo-but-opposite-in-vitro
#20
Tsung-Jen Liao, Chung-Jung Tsai, Hyunbum Jang, David Fushman, Ruth Nussinov
Is RASSF5 a tumor suppressor or activator? RASSF5 links K-Ras and the Hippo pathway. Hippo's signaling promotes YAP1 phosphorylation and degradation. YAP1 overexpression promotes cancer. Most reports point to RASSF5 suppressing cancer; however, some point to its promoting cancer. Our mechanistic view explains how RASSF5 can activate MST1/2 and suppress cancer in vivo; but inhibits MST1/2 in vitro. We propose that both activation and inhibition of MST1/2 can take place via SARAH heterodimerization. Our thesis in vivo, membrane-anchored Ras dimers (or nanoclusters) can promote SARAH domain heterodimerization, Raf-like MST1/2 kinase domain homodimerization and trans-autophosphorylation...
September 16, 2016: Current Opinion in Structural Biology
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