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https://www.readbyqxmd.com/read/28240568/-re-moving-the-needle-prospects-for-all-oral-treatment-for-multidrug-resistant-tuberculosis
#1
M Milstein, A Brzezinski, F Varaine, C D Mitnick
BACKGROUND: Currently recommended regimens for multidrug-resistant tuberculosis (MDR-TB) contain painful daily injections and are unsuccessful in approximately half of patients. Removal of the injectable agent to fashion all-oral regimens could transform MDR-TB treatment and access to care. OBJECTIVE: To explore evidence for all-oral treatment regimens. DESIGN: We review evidence on drugs that could be included in injection-free MDR-TB regimens...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28239995/a-randomized-controlled-trial-of-a-brief-intervention-for-alcohol-and-drugs-linked-to-the-alcohol-smoking-and-substance-involvement-screening-test-assist-in-primary-health-care-in-chile
#2
Fernando Poblete, Nicolas A Barticevic, M Soledad Zuzulic, Rodrigo Portilla, Alvaro Castillo-Carniglia, Jaime C Sapag, Luis Villarroel, Brena F Sena, Magdalena Galarce
AIM: To study the effectiveness of a Brief Intervention (BI) associated with the ASSIST (Alcohol Smoking and Substance Involvement Screening Test) for alcohol and illicit drug use as part of a systematic screening program implemented in primary care. DESIGN: A multi-center randomized open-label trial stratified using the ASSIST-specific substance involvement score (for alcohol, scores ranged from 11 to 15 and 16 to 20; and for the other substances, from 4 to 12 and 13 to 20)...
February 27, 2017: Addiction
https://www.readbyqxmd.com/read/28238251/percutaneous-pulmonary-valve-implantation-in-the-patched-right-ventricular-outflow-tract-51-years-after-surgical-repair-for-tetralogy-of-fallot
#3
Sebastian Grundmann, René Hoehn, Johannes Kroll, Jochen Grohmann
Percutaneous pulmonary valve implantation (PPVI) has become a widely practiced treatment option for patients with right ventricular outflow tract (RVOT) dysfunction. For this procedure, the Melody transcatheter pulmonary valve has become the most widely used system. On-label indications are limited to the treatment of failing circumferential conduits. However, there is growing but still limited experience with the off-label treatment of native or patched RVOTs. Here, the case is reported of a 57-year-old patient in whom redo-surgery for a dysfunctional pulmonary valve could be avoided by PPVI into the patched RVOT at 51 years after tetralogy of Fallot repair...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28236798/adherence-and-safety-study-in-patients-on-treatment-with-capecitabine
#4
Francisca Fernández-Ribeiro, Rosario Olivera-Fernández, Carlos Crespo-Diz
BACKGROUND: The introduction of oral antineoplastic agents in therapeutics has caused a change in the treatment strategy against cancer. The objective of this study was to analyze the adherence in patients to treatment with capecitabine, their adverse events, and the overall health status of patients, as well as the relationship of these factors with adherence. METHOD: An observational, prospective study at 7 months, in a cohort of patients on capecitabine treatment, including treatment initiations and continuations, regardless of diagnosis or indication...
March 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28236649/spectral-characterization-of-tissues-in-high-spectral-and-spatial-resolution-mr-images-implications-for-a-classification-based-synthetic-ct-algorithm
#5
Abbie M Wood, Steven M Shea, Milica Medved, Gregory S Karczmar, Murat Surucu, Sebastien Gros, William Small, John Roeske
PURPOSE: To characterize spectral parameters of tissues with high spectral and spatial resolution magnetic resonance images to be used as a foundation for a classification-based synthetic CT algorithm. METHODS: A phantom was constructed consisting of a section of fresh beef leg with bone embedded in a 1% agarose gel. The high spectral and spatial (HiSS) resolution MR imaging sequence used had 1.0mm in-plane resolution and 11.1Hz spectral resolution. This sequence was used to image the phantom and one patient...
February 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28235786/systematic-account-of-animal-poisonings-in-germany-2012-2015
#6
S E McFarland, R H Mischke, C Hopster-Iversen, X von Krueger, H Ammer, H Potschka, A Stürer, K Begemann, H Desel, M Greiner
A systematic retrospective study on animal poisonings in Germany (wildlife excluded) between January 2012 and December 2015 was conducted. Data were collected on animal exposure calls to German poison centres, poisoning cases presenting to the University of Veterinary Medicine, Hannover Small Animal and Equine Clinics, cases involving off-label use of veterinary medicinal products reported to the Federal Office of Consumer Protection and Food Safety and toxicological submissions to the Institute of Pharmacology, Toxicology, and Pharmacy, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich...
February 24, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28230456/off-label-prescribing-for-children-with-migraines-in-u-s-ambulatory-care-settings
#7
L Leanne Lai, Leroy Koh, Jane Ai-Chen Ho, Alexander Ting, Augustine Obi
BACKGROUND: Migraines, Which Affect About 10% Of School-Age Children In The United States, Can Significantly Impair Quality Of Life. Despite Potential Disability, Many Children Do Not Receive Treatment Or Prophylaxis, Since Medications Specifically Approved For Children Are Significantly Less Than For Adults. There Is Also Controversy Surrounding The Apparent Widespread Practice Of Prescribing Off-Label Medications For Children With Migraines. However, Little Research Has Been Done To Identify Physician-Prescribing Patterns Of Migraine Medication For Children...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28229174/characterization-of-the-specific-interaction-between-the-dna-aptamer-sgc8c-and-protein-tyrosine-kinase-7-receptors-at-the-surface-of-t-cells-by-biosensing-afm
#8
Michael Leitner, Alexandra Poturnayova, Constanze Lamprecht, Sabine Weich, Maja Snejdarkova, Ivana Karpisova, Tibor Hianik, Andreas Ebner
We studied the interaction of the specific DNA aptamer sgc8c immobilized at the AFM tip with its corresponding receptor, the protein tyrosine kinase-7 (PTK7) embedded in the membrane of acute lymphoblastic leukemia (ALL) cells (Jurkat T-cells). Performing single molecule force spectroscopy (SMFS) experiments, we showed that the aptamer sgc8c bound with high probability (38.3 ± 7.48%) and high specificity to PTK7, as demonstrated by receptor blocking experiments and through comparison with the binding behavior of a nonspecific aptamer...
February 22, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28228380/off-label-indications-for-antidepressants-in-primary-care-descriptive-study-of-prescriptions-from-an-indication-based-electronic-prescribing-system
#9
Jenna Wong, Aude Motulsky, Michal Abrahamowicz, Tewodros Eguale, David L Buckeridge, Robyn Tamblyn
Objective To examine off-label indications for antidepressants in primary care and determine the level of scientific support for off-label prescribing.Design Descriptive study of antidepressant prescriptions written by primary care physicians using an indication based electronic prescribing system.Setting Primary care practices in and around two major urban centres in Quebec, Canada.Participants Patients aged 18 years or older who visited a study physician between 1 January 2003 and 30 September 2015 and were prescribed an antidepressant through the electronic prescribing system...
February 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28225977/identifying-the-incidence-of-rash-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-patients-taking-lamotrigine-a-systematic-review-of-122-randomized-controlled-trials
#10
Romi Bloom, Kyle T Amber
Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. We performed a systematic review of randomized controlled trials using lamotrigine as a monotherapy to quantify the incidence of cutaneous reactions, particularly Stevens-Johnson syndrome/toxic epidermal necrolysis. Of a total of 4,364 papers regarding lamotrigine, 122 studies met our inclusion and exclusion criteria...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28224170/multicenter-off-label-use-of-nit-occlud-coil-in-retrograde-closure-of-small-patent-ductus-arteriosus
#11
Keyhan Sayadpour Zanjani, Rodina Sobhy, Rania El-Kaffas, Amal El-Sisi
We studied the safety and efficacy of closing patent ductus arteriosus by Nit-Occlud coils via retrograde approach. This is a retrospective study of 46 attempts to close ducts by this method in two hospitals in Egypt and Iran. Ductus arteriosus was crossed by left or right Judkins or endhole catheters. The coil was delivered via the same catheter or the provided endhole catheter after exchange. The procedure was successful in 42 out of 46 attempts. Fluoroscopy and procedural times were significantly shorter when the catheter was not exchanged...
February 21, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28224096/off-label-use-of-sulfur-hexafluoride-in-voiding-urosonography-for-diagnosis-of-vesicoureteral-reflux-in-children-a-survey-on-adverse-events
#12
Alexander Sauer, Clemens Wirth, Isabel Platzer, Henning Neubauer, Simon Veldhoen, Alexander Dierks, Reinhard Kaiser, Andreas Kunz, Meinrad Beer, Thorsten Bley
AIM: To evaluate the risk profile of sulfur hexafluoride in voiding urosonography (VUS) based on a large cohort of children. METHODS: Since 2011 sulfur hexafluoride (SH, SonoVue(®), Bracco, Italy) is the only ultrasound contrast available in the European Union and its use in children has not been approved. Within a 4-year-period, 531 children with suspected or proven vesicoureteral reflux (f/m = 478/53; mean age 4.9 years; 1 mo-25.2 years) following parental informed consent underwent VUS with administration of 2...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28223288/off-label-prescribing-of-antidepressants
#13
EDITORIAL
Daniel R Morales, Bruce Guthrie
No abstract text is available yet for this article.
February 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28222768/ki-67-as-a-controversial-predictive-and-prognostic-marker-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy
#14
Balázs Ács, Veronika Zámbó, Laura Vízkeleti, A Marcell Szász, Lilla Madaras, Gyöngyvér Szentmártoni, Tímea Tőkés, Béla Á Molnár, István Artúr Molnár, Stefan Vári-Kakas, Janina Kulka, Anna-Mária Tőkés
BACKGROUND: Studies have partly demonstrated the clinical validity of Ki-67 as a predictive marker in the neoadjuvant setting, but the question of the best cut-off points as well as the importance of this marker as a prognostic factor in partial responder/non-responder groups remains uncertain. METHODS: One hundred twenty patients diagnosed with invasive breast cancer and treated with neoadjuvant chemotherapy (NAC) between 2002 and 2013 were retrospectively recruited to this study...
February 21, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28220945/off-label-mri-in-2017-of-cieds-a-daily-fork-in-the-road-for-implanters-and-the-case-for-common-sense
#15
EDITORIAL
J Rod Gimbel
Both non-MRI conditional and MRI conditional systems are widely available. Physicians must choose which type of device to place. While off-label MRI can often be done safely, significant administrative and financial burdens remain to the physician posing a significant dilemma as to which device to choose. These issues are reviewed in a detailed direct manner. This article is protected by copyright. All rights reserved.
February 21, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28219694/lenalidomide-maintenance-in-patients-with-relapsed-diffuse-large-b-cell-lymphoma-who-are-not-eligible-for-autologous-stem-cell-transplantation-an-open-label-single-arm-multicentre-phase-2-trial
#16
Andrés J M Ferreri, Marianna Sassone, Francesco Zaja, Alessandro Re, Michele Spina, Alice Di Rocco, Alberto Fabbri, Caterina Stelitano, Maurizio Frezzato, Chiara Rusconi, Renato Zambello, Suzana Couto, Yan Ren, Annalisa Arcari, Giovanni Bertoldero, Alessandro Nonis, Lydia Scarfò, Teresa Calimeri, Caterina Cecchetti, Marianna Chiozzotto, Silvia Govi, Maurilio Ponzoni
BACKGROUND: Patients with relapsed diffuse large B-cell lymphoma (DLBCL) not eligible for autologous stem cell transplantation (ASCT) or having relapse after ASCT have a low likelihood of cure. Single-drug maintenance after salvage therapy might be an attractive strategy to prolong survival in these patients. Lenalidomide is a suitable candidate for long-lasting maintenance as it is an oral drug, active against DLBCL that can be taken for years with an acceptable toxicity profile. We designed a study to investigate safety and efficacy of lenalidomide maintenance in patients with chemosensitive relapse of DLBCL not eligible for ASCT or having relapse after ASCT...
February 16, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28218925/off-label-prescribing-and-polypharmacy-minimizing-the-risks
#17
Laura G Leahy
Off-label prescribing and polypharmacy are commonplace in today's health care environment. Patients are treated with multiple medications obtained through multiple providers, and all too frequently, there is no collaboration amongst professionals. Nurses can address these issues by educating themselves and their patients regarding medication indications and uses, side effects, risks, and benefits. By exploring a patient's medication reconciliation, including over-the-counter agents, and identifying the U.S...
February 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28215909/eslicarbazepine-acetate-for-neuropathic-pain-headache-and-cranial-neuralgia-evidence-and-experience
#18
A Alcántara Montero, C I Sánchez Carnerero
INTRODUCTION: Eslicarbazepine acetate (ESL), together with carbamazepine and oxcarbazepine, belongs to the dibenzazepine family. According to the latest clinical practice guidelines, tricyclic antidepressants, dual antidepressants (venlafaxine, duloxetine), and some antiepileptics (gabapentin, pregabalin) are first-line drugs for neuropathic pain; tramadol, lidocaine 5% patches, and capsaicin 8% patches are considered second-line drugs; and strong opioids constitute a third line of treatment...
February 16, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28213003/the-expression-of-pd-l1-protein-as-a-prognostic-factor-in-lung-squamous-cell-carcinoma
#19
Kazuki Takada, Tatsuro Okamoto, Gouji Toyokawa, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Fumihiro Shoji, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND: Programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway-targeted immunotherapy has become the standard option of care in the management of lung cancer. The expression of the PD-L1 protein in lung cancer is expected to be a prognostic factor or to predict the response to PD-1-blocking antibodies. However, the association between PD-L1 positivity and the clinicopathological features and patient outcomes in lung squamous cell carcinoma (SCC) remains unclear because the definitive cut-off value for the expression of PD-L1 protein remains to be established...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28213002/a-phase-ii-trial-of-dovitinib-in-previously-treated-advanced-pleural-mesothelioma-the-ontario-clinical-oncology-group
#20
Scott A Laurie, Desiree Hao, Natasha B Leighl, John Goffin, Abderrahim Khomani, Ashish Gupta, Christina L Addison, Anita Bane, Jean Seely, Marc L Filion, Gregory R Pond, Mark N Levine
OBJECTIVES: Following failure of a platinum-antifolate combination regimen, there is no standard therapy for advanced malignant pleural mesothelioma (MPM). The fibroblast growth factor receptor (FGFR) signaling pathways may be a relevant target in MPM. Dovitinib inhibits multiple tyrosine receptor kinases, predominantly the vascular endothelial growth factor receptors (VEGFR), but also FGFRs, and could be active in MPM. METHODS: This open-label multicentre phase II trial [NCT01769547] enrolled fit, consenting adult patients with advanced MPM who had previously received platinum-antifolate combination chemotherapy and up to one additional line of systemic therapy...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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