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Fructose intolerance

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https://www.readbyqxmd.com/read/27834291/sex-differences-in-the-metabolic-dysfunction-and-insulin-resistance-of-skeletal-muscle-glucose-transport-following-high-fructose-ingestion
#1
Yupaporn Rattanavichit, Natsasi Chukijrungroat, Vitoon Saengsirisuwan
The role of high fructose ingestion (HFI) in the development of conditions mimicking human metabolic syndrome has mostly been demonstrated in male animals; however, the extent of HFI-induced metabolic alterations in females remains unclear. The present study investigated whether HFI-induced metabolic perturbations differ between sexes and whether HFI aggravates the metabolic disturbances under ovarian hormone deprivation. Male, female and ovariectomized (OVX) Sprague-Dawley rats were given either water or liquid fructose (10% w/v) for 6 weeks...
November 9, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27797444/hereditary-fructose-intolerance-mimicking-a-biochemical-phenotype-of-mucolipidosis-a-review-of-the-literature-of-secondary-causes-of-lysosomal-enzyme-activity-elevation-in-serum
#2
Carlos R Ferreira, Joseph M Devaney, Sean E Hofherr, Laura M Pollard, Kristina Cusmano-Ozog
We describe a patient with failure to thrive, hepatomegaly, liver dysfunction, and elevation of multiple plasma lysosomal enzyme activities mimicking mucolipidosis II or III, in whom a diagnosis of hereditary fructose intolerance (HFI) was ultimately obtained. She presented before introduction of solid foods, given her consumption of a fructose-containing infant formula. We present the most extensive panel of lysosomal enzyme activities reported to date in a patient with HFI, and propose that multiple enzyme elevations in plasma, especially when in conjunction with a normal plasma α-mannosidase activity, should elicit a differential diagnosis of HFI...
October 31, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27787351/utilization-of-positive-and-negative-controls-to-examine-comorbid-associations-in-observational-database-studies
#3
Jigar R Desai, Craig L Hyde, Shaum Kabadi, Matthew St Louis, Vinicius Bonato, A Katrina Loomis, Aaron Galaznik, Marc L Berger
BACKGROUND: Opportunities to leverage observational data for precision medicine research are hampered by underlying sources of bias and paucity of methods to handle resulting uncertainty. We outline an approach to account for bias in identifying comorbid associations between 2 rare genetic disorders and type 2 diabetes (T2D) by applying a positive and negative control disease paradigm. RESEARCH DESIGN: Association between 10 common and 2 rare genetic disorders [Hereditary Fructose Intolerance (HFI) and α-1 antitrypsin deficiency] and T2D was compared with the association between T2D and 7 negative control diseases with no established relationship with T2D in 4 observational databases...
October 26, 2016: Medical Care
https://www.readbyqxmd.com/read/27774805/-fructose-and-fructose-intolerance
#4
György Miklós Buzás
Although fructose was discovered in 1794, it was realised in recent decades only that its malabsorption can lead to intestinal symptoms while its excessive consumption induces metabolic disturbances. Fructose is a monosaccharide found naturally in most fruits and vegetables. Dietary intake of fructose has gradually increased in the past decades, especially because of the consumption of high fructose corn syrup. With its 16.4 kg/year consumption, Hungary ranks secondly after the United States. Fructose is absorbed in the small intestine by facilitated transport mediated by glucose transporter proteins-2 and -5, and arrives in the liver cells...
October 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27765371/protodioscin-ameliorates-fructose-induced-renal-injury-via-inhibition-of-the-mitogen-activated-protein-kinase-pathway
#5
Jinyang Shen, Xiaolin Yang, Zhaoqing Meng, Changrun Guo
BACKGROUND: High dietary fructose can cause metabolic syndrome and renal injury. PURPOSE: The effects of protodioscin on metabolic syndrome and renal injury were investigated in mice receiving high-dose fructose. METHODS: Mice received 30% (w/v) fructose in water and standard chow for 6 weeks to induce metabolic syndrome and were divided into four groups to receive carboxymethylcellulose sodium, allopurinol (5 mg/kg) and protodioscin (5 and 10 mg/kg) continuously for 6 weeks, respectively...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27720712/relapsing-acute-axonal-neuropathy-in-hereditary-fructose-intolerance
#6
Anna Maitre, Anna Maw, Uma Ramaswami, Sarah L Morley
BACKGROUND: A severe neurological abnormality has not been previously described in individuals with hereditary fructose intolerance, which typically presents early in childhood with severe metabolic acidosis and hypoglycemia. PATIENT DESCRIPTION: We describe a boy who by age five years had required multiple admissions to the pediatric intensive care unit for an aggressive and atypical, relapsing and remitting neuropathy with features of acute motor axonal neuropathy (AMAN)...
August 2, 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27716759/-correlation-between-the-presence-and-intensity-of-symptoms-and-the-results-of-hydrogen-breath-tests-in-the-diagnosis-of-carbohydrate-intolerance
#7
María Teresa Sánchez-Ávila, Karla Lorena Chávez Caraza, Adrián Marcelo González Gil, Jaime Javier Cantú Pompa, Edgar Moreno Medrano, Luis Alonso Morales-Garza
BACKGROUND: Hydrogen breath tests (HBT) are used to confirm the diagnosis of carbohydrate intolerance or small intestinal bacterial overgrowth (SIBO). OBJECTIVE: Determine the existence of a correlation between the presence and intensity of symptoms experimented by the patient after the ingestion of a carbohydrate load and the test result. MATERIALS AND METHODS: This is an observational, retrospective and analytic study, in which all patients' files from year 2008 to 2014 containing a report of a HBT performed at Hospital San José TEC de Monterrey were revised...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27699590/high-fructose-diet-is-as-detrimental-as-high-fat-diet-in-the-induction-of-insulin-resistance-and-diabetes-mediated-by-hepatic-pancreatic-endoplasmic-reticulum-er-stress
#8
M Balakumar, L Raji, D Prabhu, C Sathishkumar, P Prabu, V Mohan, M Balasubramanyam
In the context of high human consumption of fructose diets, there is an imperative need to understand how dietary fructose intake influence cellular and molecular mechanisms and thereby affect β-cell dysfunction and insulin resistance. While evidence exists for a relationship between high-fat-induced insulin resistance and metabolic disorders, there is lack of studies in relation to high-fructose diet. Therefore, we attempted to study the effect of different diets viz., high-fat diet (HFD), high-fructose diet (HFS), and a combination (HFS + HFD) diet on glucose homeostasis and insulin sensitivity in male Wistar rats compared to control animals fed with normal pellet diet...
October 3, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27669460/chrebp-regulates-fructose-induced-glucose-production-independently-of-insulin-signaling
#9
Mi-Sung Kim, Sarah A Krawczyk, Ludivine Doridot, Alan J Fowler, Jennifer X Wang, Sunia A Trauger, Hye-Lim Noh, Hee Joon Kang, John K Meissen, Matthew Blatnik, Jason K Kim, Michelle Lai, Mark A Herman
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant. Specifically, insulin fails to suppress glucose production, yet successfully stimulates de novo lipogenesis. The mechanisms underlying this dysregulation remain controversial. Here, we hypothesized that carbohydrate-responsive element-binding protein (ChREBP), a transcriptional activator of glycolytic and lipogenic genes, plays a central role in this paradox...
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27371158/role-of-antigen-presenting-cell-invariant-chain-in-the-development-of-hepatic-steatosis-in-mouse-model
#10
Alaknanda Mishra, Srikanth Iyer, Ashwani Kesarwani, Prakash Baligar, Satya Pal Arya, Shailendra Arindkar, M J Mahesh Kumar, Pramod Upadhyay, Subeer S Majumdar, Perumal Nagarajan
The role of Invariant chain (CD74 or Ii) in antigen presentation via Antigen Presenting Cells (APC), macrophage recruitment as well as survival, T cell activation and B cell differentiation has been well recognized. However, the aspect of CD74 which is involved in the development of hepatic steatosis and the pathways through which it acts remain to be studied. In this study, we investigated the role of CD74 in the inflammatory pathway and its contribution to development of hepatic steatosis. For this, wild type C57BL/6J and CD74 deficient mice (Ii(-/-) mice) were fed with high fat high fructose (HFHF) diet for 12 weeks...
August 15, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27216413/aspartame-intake-is-associated-with-greater-glucose-intolerance-in-individuals-with-obesity
#11
Jennifer L Kuk, Ruth E Brown
This study examined whether sucrose, fructose, aspartame, and saccharin influences the association between obesity and glucose tolerance in 2856 adults from the NHANES III survey. Aspartame intake significantly influenced the association between body mass index (BMI) and glucose tolerance (interaction: P = 0.004), wherein only those reporting aspartame intake had a steeper positive association between BMI and glucose tolerance than those reporting no aspartame intake. Therefore, consumption of aspartame is associated with greater obesity-related impairments in glucose tolerance...
July 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27215624/-food-allergy-and-intolerance-distinction-definitions-and-delimitation
#12
Jörg Kleine-Tebbe, Anja Waßmann-Otto, Hubert Mönnikes
Immunologically mediated hypersensitivity to foods is defined as food allergy, mainly due to immunglobulins of class E (IgE) triggering immediate reactions (type I hypersensitivity) with possible involvement of mucosa, skin, airways, intestinal tract, and the vascular system. Primary food allergy is based on (early) IgE sensitization against animal (e. g., cow's milk, hen's eggs) or plant proteins (e. g. peanut, hazelnut or wheat). In the case of secondary food allergies, IgE against pollen proteins (e...
June 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27188621/-food-intolerances-caused-by-enzyme-defects-and-carbohydrate-malassimiliations-lactose-intolerance-and-co
#13
Christiane Schäfer
Apart from allergic conditions, carbohydrate malassimiliations (sugar metabolism disorders) are classified within the group of food intolerances. These dose-dependent, yet non-immunological reactions require gastroenterological or internal diagnosis following nutritional therapy. Intolerances to carbohydrates such as lactose (milk sugar) and fructose (fruit sugar) in addition to sugar alcohols (sorbitol, mannitol, lactitol etc.) have been gaining increasing attention in recent decades as they are the cause of a wide range of gastrointestinal symptoms...
June 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27186159/the-unexpected-truth-about-dates-and-hypoglycemia
#14
Mohammed I Yasawy
BACKGROUND: Dates are a concentrated source of essential nutrients, vitamins, minerals, and carbohydrates (CHOs), which are necessary for the maintenance of optimum health. Most of the CHOs in dates come from sugars including glucose and fructose. Dates are commonly consumed in Saudi Arabia, particularly at the time of breaking the fast to provide instant energy and maintain blood sugar level. However, dates may cause hypoglycemia in a rare condition named as heredity fructose intolerance (HFI), and a few families have been to see us with a history of that nature...
May 2016: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/27065730/do-patients-with-lactose-intolerance-exhibit-more-frequent-comorbidities-than-patients-without-lactose-intolerance-an-analysis-of-routine-data-from-german-medical-practices
#15
Rebecca Schiffner, Karel Kostev, Holger Gothe
BACKGROUND: The increase in food intolerances poses a burgeoning problem in our society. Food intolerances not only lead to physical impairment of the individual patient but also result in a high socio-economic burden due to factors such as the treatment required as well as absenteeism. The present study aimed to explore whether lactose intolerant (LI) patients exhibit more frequent comorbidities than non-LI patients. METHODS: The study was conducted on a case-control basis and the results were determined using routine data analysis...
April 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/26997538/molecular-mechanisms-of-lipotoxicity-and-glucotoxicity-in-nonalcoholic-fatty-liver-disease
#16
Manoela Mota, Bubu A Banini, Sophie C Cazanave, Arun J Sanyal
The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A common denominator is metabolic derangement, especially in regards to intracellular energy homeostasis, which is brought on by glucose intolerance and insulin resistance in tissues. In this review, we highlight the lipids and carbohydrates that provoke hepatocyte injury and the mechanisms involved in lipotoxicity and glucotoxicity, including endoplasmic reticulum stress, oxidative stress and mitochondrial impairment...
August 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/26937407/hereditary-fructose-intolerance-in-brazilian-patients
#17
Eugênia Ribeiro Valadares, Ana Facury da Cruz, Talita Emile Ribeiro Adelino, Viviane de Cássia Kanufre, Maria do Carmo Ribeiro, Maria Goretti Moreira Guimarães Penido, Luciano Amedee Peret Filho, Laís Maria Santos Valadares E Valadares
No abstract text is available yet for this article.
September 2015: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/26934776/a-glucose-centric-perspective-of-hyperglycemia
#18
REVIEW
T Ramasarma, M Rafi
Digestion of food in the intestines converts the compacted storage carbohydrates, starch and glycogen, to glucose. After each meal, a flux of glucose (> 200 g) passes through the blood pool (4-6 g) in a short period of 2 h, keeping its concentration ideally in the range of 80-120 mg/100 mL. Tissue-specific glucose transporters (GLUTs) aid in the distribution of glucose to all tissues. The balance glucose after meeting the immediate energy needs is converted into glycogen and stored in liver (up to 100 g) and skeletal muscle (up to 300 g) for later use...
February 2016: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/26874528/differential-modulation-of-cytosolic-lipases-activities-in-liver-and-adipose-tissue-by-high-carbohydrate-diets
#19
Angélica Heringer Rodrigues, Carolina Campos Lima Moreira, Érica Guilhen Mario, Letícia Maria de Souza Cordeiro, Gleide Fernandes Avelar, Leida Maria Botion, Valéria Ernestânia Chaves
Several studies have demonstrated that a high-fructose (FRUC) diet induces metabolic and haemodynamic abnormalities, known as the metabolic syndrome, which are characterised by obesity, glucose intolerance, insulin resistance, dyslipidaemia and hypertension. In this study, the effect of a FRUC diet (60 % fructose) for 8 weeks on the metabolism of lipids in liver and epididymal adipose tissue from Wistar rats was compared with the AIN-93M diet and the effects of the AIN-93M diet were compared with a chow diet...
August 2016: Endocrine
https://www.readbyqxmd.com/read/26770008/evaluation-of-the-in-vivo-and-in-vitro-effects-of-fructose-on-respiratory-chain-complexes-in-tissues-of-young-rats
#20
Ernesto António Macongonde, Thais Ceresér Vilela, Giselli Scaini, Cinara Ludvig Gonçalves, Bruna Klippel Ferreira, Naithan Ludian Fernandes Costa, Marcos Roberto de Oliveira, Silvio Avila Junior, Emilio Luiz Streck, Gustavo Costa Ferreira, Patrícia Fernanda Schuck
Hereditary fructose intolerance (HFI) is an autosomal-recessive disorder characterized by fructose and fructose-1-phosphate accumulation in tissues and biological fluids of patients. This disease results from a deficiency of aldolase B, which metabolizes fructose in the liver, kidney, and small intestine. We here investigated the effect of acute fructose administration on the activities of mitochondrial respiratory chain complexes, succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) in cerebral cortex, liver, kidney, and skeletal muscle of male 30-day-old Wistar rats...
2015: Disease Markers
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