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Fructose intolerance

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https://www.readbyqxmd.com/read/28714504/tartary-buckwheat-flavonoids-ameliorate-high-fructose-induced-insulin-resistance-and-oxidative-stress-associated-with-the-insulin-signaling-and-nrf2-ho-1-pathways-in-mice
#1
Yuanyuan Hu, Zuoxu Hou, Ruokun Yi, Zhongming Wang, Peng Sun, Guijie Li, Xin Zhao, Qiang Wang
The present study was conducted to explore the effects of a purified tartary buckwheat flavonoid fraction (TBF) on insulin resistance and hepatic oxidative stress in mice fed high fructose in drinking water (20%) for 8 weeks. The results indicated that continuous administration of TBF dose-dependently improved the insulin sensitivity and glucose intolerance in high fructose-fed mice. TBF treatment also reversed the reduced level of insulin action on the phosphorylation of insulin receptor substrate-1 (IRS-1), protein kinase B (Akt) and phosphatidylinositol 3-kinase (PI3K), as well as the translocation of glucose transporter type 4 (GLUT4) in the insulin-resistant liver...
July 17, 2017: Food & Function
https://www.readbyqxmd.com/read/28672432/pros-and-cons-while-looking-through-an-asian-window-on-the-rome-iv-criteria-for-irritable-bowel-syndrome-pros
#2
REVIEW
Uday C Ghoshal
A decade after Rome III, in 2016, Rome IV criteria were published. There are major differences between Rome IV and the earlier iteration, some of which are in line with Asian viewpoints. The clinical applicability of the Rome IV criteria of irritable bowel syndrome (IBS) in Asian perspective is reviewed here. Instead of considering functional gastrointestinal disorders (FGIDs) to be largely psychogenic, Rome IV suggested the importance of the gut over brain ("disorders of gut-brain interaction" not "brain-gut interaction")...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28580946/dopamine-d2-receptor-signaling-in-the-nucleus-accumbens-comprises-a-metabolic-cognitive-brain-interface-regulating-metabolic-components-of-glucose-reinforcement
#3
Michael Michaelides, Michael L Miller, Jennifer A DiNieri, Juan L Gomez, Elizabeth Schwartz, Gabor Egervari, Gene Jack Wang, Charles V Mobbs, Nora D Volkow, Yasmin L Hurd
Appetitive drive is influenced by coordinated interactions between brain circuits that regulate reinforcement and homeostatic signals that control metabolism. Glucose modulates striatal dopamine (DA), and regulates appetitive drive and reinforcement learning. Striatal DA D2 receptors (D2R) also regulate reinforcement learning, and are implicated in glucose-related metabolic disorders. Nevertheless, interactions between striatal D2R and peripheral glucose have not been previously described. Here we show that manipulations involving striatal D2R signaling coincide with perseverative and impulsive-like responding for sucrose, a disaccharide consisting of fructose and glucose...
June 5, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28555043/chronic-fructose-ingestion-as-a-major-health-concern-is-a-sedentary-lifestyle-making-it-worse-a-review
#4
REVIEW
Amy J Bidwell
Obesity contributes to metabolic abnormalities such as insulin resistance, dyslipidemia, hypertension, and glucose intolerance, all of which are risk factors associated with metabolic syndrome. The growing prevelance of metabolic syndrome seems to be an end result of our current lifestyle which promotes high caloric, high-fat foods and minimal physical activity, resulting in a state of positive energy balance. Increased adiposity and physical inactivity may represent the beginning of the appearance of these risk factors...
May 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28536120/hepatocyte-specific-sirtuin-6-deletion-predisposes-to-nonalcoholic-steatohepatitis-by-up-regulation-of-bach1-an-nrf2-repressor
#5
Sun-O Ka, In Hyuk Bang, Eun Ju Bae, Byung-Hyun Park
Sirtuin (Sirt)6 has been implicated in negative regulation of inflammation and lipid metabolism, although its function in the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains to be defined. To explore the role of hepatocyte Sirt6 in NASH development, we generated hepatocyte-specific Sirt6 knockout (KO) mice that were fed a high-fat and high-fructose (HFHF) diet for 16 wk. HFHF-fed KO mice had increased hepatic steatosis and inflammation and aggravated glucose intolerance and insulin resistance compared with wild-type mice...
May 23, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28513533/deleterious-metabolic-effects-of-high-fructose-intake-the-preventive-effect-of-lactobacillus-kefiri-administration
#6
María Guillermina Zubiría, Sabrina Eliana Gambaro, María Amanda Rey, Paula Carasi, María de Los Ángeles Serradell, Andrés Giovambattista
Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20% w/v) drinking water supplemented or not with L. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD...
May 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28499147/fructose-increases-corticosterone-production-in-association-with-nadph-metabolism-alterations-in-rat-epididymal-white-adipose-tissue
#7
Paula D Prince, Yanina A Santander, Estefania M Gerez, Christian Höcht, Ariel H Polizio, Marcos A Mayer, Carlos A Taira, Cesar G Fraga, Monica Galleano, Andrea Carranza
Metabolic syndrome is an array of closely metabolic disorders that includes glucose intolerance/insulin resistance, central obesity, dyslipidemia, and hypertension. Fructose, a highly lipogenic sugar, has profound metabolic effects in adipose tissue, and has been associated with the etiopathology of many components of the metabolic syndrome. In adipocytes, the enzyme 11 β-HSD1 amplifies local glucocorticoid production, being a key player in the pathogenesis of central obesity and metabolic syndrome. 11 β-HSD1 reductase activity is dependent on NADPH, a cofactor generated by H6PD inside the endoplasmic reticulum...
April 6, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28495843/treating-fructose-induced-metabolic-changes-in-mice-with-high-intensity-interval-training-insights-in-the-liver-white-adipose-tissue-and-skeletal-muscle
#8
Victor Faria Motta, Thereza Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Fructose-rich caloric sweeteners induce adverse changes in the population metabolism. The study evaluated the effects of high-intensity interval training (HIIT) on a fructose feeding model, focusing on the liver, white adipose tissue (WAT), skeletal muscle, and their interplay. Male C57BL/6 mice were fed for 18 weeks one of the following diets: control (C; 5 % of total energy from fructose), or fructose (F; 55 % of total energy from fructose). In the 10th week, for an additional eight-week period the groups were divided into non-trained (NT) or HIIT groups, totaling four groups: C-NT, C-HIIT, F-NT, and F-HIIT...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28420148/differential-effect-of-sucrose-and-fructose-in-combination-with-a-high-fat-diet-on-intestinal-microbiota-and-kidney-oxidative-stress
#9
Adriana Rosas-Villegas, Mónica Sánchez-Tapia, Azalia Avila-Nava, Victoria Ramírez, Armando R Tovar, Nimbe Torres
There is controversial information about the adverse effect of sucrose (S) or fructose (F) in the development of obesity. Thus, the purpose of the study was to evaluate the effect of S or F in a high fat diet (HF) on gut microbiota and renal oxidative stress. Rats were fed for four months with either high-fat + sucrose (HFS) or high-fat + fructose (HFF) or a control diet (C). Half of the HFS or HFF groups were maintained with the same diet and the other half were switched to the consumption of C. HFS and HFF groups increased 51% and 19% body weight, respectively, compared with the C group...
April 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28411097/-acute-liver-failure-related-to-inherited-metabolic-diseases-in-young-children
#10
Filipa Dias Costa, Rita Moinho, Sandra Ferreira, Paula Garcia, Luísa Diogo, Isabel Gonçalves, Carla Pinto
INTRODUCTION: Pediatric acute liver failure (ALF) due to inherited metabolic diseases (IMD) is a rare life-threatening condition with a poor prognosis. Early intervention may be lifesaving. OBJECTIVE: To describe clinical presentation, investigation and outcomes of ALF related to IMD in young children. MATERIAL AND METHODS: Retrospective review of the medical records of children aged up to 24 months, admitted to a tertiary pediatric and neonatal Intensive Care Unit during a 27-year period, fulfilling the ALF criteria, with documented metabolic etiology...
April 11, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28368361/inborn-errors-of-fructose-metabolism-what-can-we-learn-from-them
#11
REVIEW
Christel Tran
Fructose is one of the main sweetening agents in the human diet and its ingestion is increasing globally. Dietary sugar has particular effects on those whose capacity to metabolize fructose is limited. If intolerance to carbohydrates is a frequent finding in children, inborn errors of carbohydrate metabolism are rare conditions. Three inborn errors are known in the pathway of fructose metabolism; (1) essential or benign fructosuria due to fructokinase deficiency; (2) hereditary fructose intolerance; and (3) fructose-1,6-bisphosphatase deficiency...
April 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28347724/metabolic-effects-of-intermittent-access-to-caloric-or-non-caloric-sweetened-solutions-in-mice-fed-a-high-caloric-diet
#12
Marion Soto, Catherine Chaumontet, Patrick C Even, Dalila Azzout-Marniche, Daniel Tomé, Gilles Fromentin
Human consumption of obesogenic diets and soft drinks, sweetened with different molecules, is increasing worldwide, and increases the risk of metabolic diseases. We hypothesized that the chronic consumption of caloric (sucrose, high-fructose corn syrup (HFCS), maltodextrin) and non-caloric (sucralose) solutions under 2-hour intermittent access, alongside the consumption of a high-fat high-sucrose diet, would result in differential obesity-associated metabolic abnormalities in mice. Male C57BL/6 mice had ad libitum access to an HFHS diet and to water (water control group)...
June 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28346369/metabolic-impact-of-light-phase-restricted-fructose-consumption-is-linked-to-changes-in-hypothalamic-ampk-phosphorylation-and-melatonin-production-in-rats
#13
Juliana de Almeida Faria, Thiago Matos F de Araújo, Daniela S Razolli, Letícia Martins Ignácio-Souza, Dailson Nogueira Souza, Silvana Bordin, Gabriel Forato Anhê
Recent studies show that the metabolic effects of fructose may vary depending on the phase of its consumption along with the light/dark cycle. Here, we investigated the metabolic outcomes of fructose consumption by rats during either the light (LPF) or the dark (DPF) phases of the light/dark cycle. This experimental approach was combined with other interventions, including restriction of chow availability to the dark phase, melatonin administration or intracerebroventricular inhibition of adenosine monophosphate-activated protein kinase (AMPK) with Compound C...
March 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28336170/-drug-syrups-errors-in-drug-labels-with-possible-consequences-in-patients-with-heritary-fructose-intolerance
#14
Elsa Izquierdo-García, Ismael Escobar Rodríguez, José Manuel Moreno-Villares, Irene Iglesias Peinado
No abstract text is available yet for this article.
March 20, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28028036/reduced-islet-function-contributes-to-impaired-glucose-homeostasis-in-fructose-fed-mice
#15
Zeenat A Asghar, Andrew Cusumano, Zihan Yan, Maria S Remedi, Kelle H Moley
Increased sugar consumption, particularly fructose, in the form of sweetened beverages and sweeteners in our diet adversely affects metabolic health. Because these effects are associated with features of the metabolic syndrome in humans, the direct effect of fructose on pancreatic islet function is unknown. Therefore, we examined the islet phenotype of mice fed excess fructose. Fructose-fed mice exhibited fasting hyperglycemia and glucose intolerance but not hyperinsulinemia, dyslipidemia, or hyperuricemia...
February 1, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27930685/exercise-training-prevents-cardiovascular-derangements-induced-by-fructose-overload-in-developing-rats
#16
Daniela Farah, Jonas Nunes, Michelle Sartori, Danielle da Silva Dias, Raquel Sirvente, Maikon B Silva, Patrícia Fiorino, Mariana Morris, Susana Llesuy, Vera Farah, Maria-Cláudia Irigoyen, Kátia De Angelis
The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning...
2016: PloS One
https://www.readbyqxmd.com/read/27834291/sex-differences-in-the-metabolic-dysfunction-and-insulin-resistance-of-skeletal-muscle-glucose-transport-following-high-fructose-ingestion
#17
Yupaporn Rattanavichit, Natsasi Chukijrungroat, Vitoon Saengsirisuwan
The role of high fructose ingestion (HFI) in the development of conditions mimicking human metabolic syndrome has mostly been demonstrated in male animals; however, the extent of HFI-induced metabolic alterations in females remains unclear. The present study investigated whether HFI-induced metabolic perturbations differ between sexes and whether HFI aggravates the metabolic disturbances under ovarian hormone deprivation. Male, female, and ovariectomized (OVX) Sprague-Dawley rats were given either water or liquid fructose (10% wt/vol) for 6 wk...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27797444/hereditary-fructose-intolerance-mimicking-a-biochemical-phenotype-of-mucolipidosis-a-review-of-the-literature-of-secondary-causes-of-lysosomal-enzyme-activity-elevation-in-serum
#18
Carlos R Ferreira, Joseph M Devaney, Sean E Hofherr, Laura M Pollard, Kristina Cusmano-Ozog
We describe a patient with failure to thrive, hepatomegaly, liver dysfunction, and elevation of multiple plasma lysosomal enzyme activities mimicking mucolipidosis II or III, in whom a diagnosis of hereditary fructose intolerance (HFI) was ultimately obtained. She presented before introduction of solid foods, given her consumption of a fructose-containing infant formula. We present the most extensive panel of lysosomal enzyme activities reported to date in a patient with HFI, and propose that multiple enzyme elevations in plasma, especially when in conjunction with a normal plasma α-mannosidase activity, should elicit a differential diagnosis of HFI...
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27787351/utilization-of-positive-and-negative-controls-to-examine-comorbid-associations-in-observational-database-studies
#19
Jigar R Desai, Craig L Hyde, Shaum Kabadi, Matthew St Louis, Vinicius Bonato, A Katrina Loomis, Aaron Galaznik, Marc L Berger
BACKGROUND: Opportunities to leverage observational data for precision medicine research are hampered by underlying sources of bias and paucity of methods to handle resulting uncertainty. We outline an approach to account for bias in identifying comorbid associations between 2 rare genetic disorders and type 2 diabetes (T2D) by applying a positive and negative control disease paradigm. RESEARCH DESIGN: Association between 10 common and 2 rare genetic disorders [Hereditary Fructose Intolerance (HFI) and α-1 antitrypsin deficiency] and T2D was compared with the association between T2D and 7 negative control diseases with no established relationship with T2D in 4 observational databases...
March 2017: Medical Care
https://www.readbyqxmd.com/read/27774805/-fructose-and-fructose-intolerance
#20
György Miklós Buzás
Although fructose was discovered in 1794, it was realised in recent decades only that its malabsorption can lead to intestinal symptoms while its excessive consumption induces metabolic disturbances. Fructose is a monosaccharide found naturally in most fruits and vegetables. Dietary intake of fructose has gradually increased in the past decades, especially because of the consumption of high fructose corn syrup. With its 16.4 kg/year consumption, Hungary ranks secondly after the United States. Fructose is absorbed in the small intestine by facilitated transport mediated by glucose transporter proteins-2 and -5, and arrives in the liver cells...
October 2016: Orvosi Hetilap
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