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Agent orange

Hong Yao, Lichun Zhou, Linlin Tang, Yanhui Guan, Shang Chen, Yu Zhang, Xiuzhen Han
Cardiomyocyte nutrient deprivation is a common clinical event that mediates various cardiac ischemic processes and is associated with autophagy activation and cell survival or death. Luteolin-7-O-glucoside (LUTG) was one of the flavonoid glycosides isolated from Dracocephalum tanguticum. Previous research had showed that LUTG pretreatment had significant protective effects against doxorubicin-induced cardiotoxicity. However, whether LUTG could protect cardiomyocytes from starvation-induced injury was not clear...
October 16, 2017: Bioscience Trends
John D Beard, Lawrence S Engel, David B Richardson, Marilie D Gammon, Coleen Baird, David M Umbach, Kelli D Allen, Catherine L Stanwyck, Jean Keller, Dale P Sandler, Silke Schmidt, Freya Kamel
BACKGROUND: Military veterans may have higher rates of amyotrophic lateral sclerosis (ALS) mortality than non-veterans. Few studies, with sparse exposure information and mixed results, have studied relationships between military-related factors and ALS survival. We evaluated associations between military-related factors and ALS survival among U.S. military veteran cases. METHODS: We followed 616 medical record-confirmed cases from enrollment (2005-2010) in the Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis study until death or July 25, 2013, whichever came first...
2017: PloS One
Fatemeh Salimi, Javad Hamedi, Elaheh Motevaseli, Fatemeh Mohammadipanah
AIM: Vascular calcification (VC) is a significant pathological process in some life-threatening diseases. Several pathological mechanisms, including transdifferentiation of vascular smooth muscle cells to osteoblast-like cells and apoptosis are involved in VC. Compounds with an inhibitory effect on these processes are potentially efficient medications. In consideration of the multiple biological activities of Actinobacteria, this research was aimed at finding anti-VC metabolite-producing Actinobacteria...
October 9, 2017: Journal of Applied Microbiology
Fernanda Aline de Moura, Fernanda Teixeira Macagnan, Lucciélli Rodrigues Dos Santos, Marilia Bizzani, Carmen Lúcia de Oliveira Petkowicz, Leila Picolli da Silva
The composition and fine structure of pectins found in plant cell walls are heterogeneous, with striking differences, depending on their source, and this eventually determines their functional and technological properties. The aim of this study was to extract and determine the chemical composition and physicochemical properties of pectins from different sources: passion fruit peel, orange pomace, and soy hull. Pectin extraction was performed with heated hydrochloric acid solution, followed by precipitation with 96% ethanol...
September 2017: Journal of Food Science and Technology
Shuwu Zhang, Yantai Gan, Weihong Ji, Bingliang Xu, Baohong Hou, Jia Liu
Heterodera avenae is an important soil-borne pathogen that affects field crops worldwide. Chemical nematicides can be used to control the nematode, but they bring toxicity to the environment and human. Trichoderma longibrachiatum has been shown to have the ability to control H. avenae cysts, but detailed microscopic observations and bioassays are lacking. In this study, we used microscopic observations and bioassays to study the effect of T. longibrachiatum T6 (TL6) on the eggs and second stage juveniles (J2s) of H...
2017: Frontiers in Plant Science
Agnieszka Kobylińska, Russel J Reiter, Malgorzata M Posmyk
Melatonin was discovered in plants more than two decades ago and, especially in the last decade, it has captured the interests of plant biologists. Beyond its possible participation in photoperiod processes and its role as a direct free radical scavenger as well as an indirect antioxidant, melatonin is also involved in plant defense strategies/reactions. However, the mechanisms that this indoleamine activates to improve plant stress tolerance still require identification and clarification. In the present report, the ability of exogenous melatonin to protect Nicotiana tabacum L...
2017: Frontiers in Plant Science
David H Woen, Guo P Chen, Joseph W Ziller, Timothy J Boyle, Filipp Furche, William J Evans
The first (N═N)(2-) complex of a rare-earth metal with an end-on dinitrogen bridge, {K(crypt)}2{[(R2N)3Sc]2[μ-η(1):η(1)-N2]} (crypt = 2.2.2-cryptand, R = SiMe3), has been isolated from the reduction of Sc(NR2)3 under dinitrogen at -35 °C and characterized by X-ray crystallography. The structure differs from the characteristic side-on structures previously observed for over 40 crystallographically characterized rare-earth metal (N═N)(2-) complexes of formula [A2Ln(THF)x]2[μ-η(2):η(2)-N2] (Ln = Sc, Y, and lanthanides; x = 0, 1; A = anionic ligand such as amide, cyclopentadienide, and aryloxide)...
October 11, 2017: Journal of the American Chemical Society
Chrystal Chang, Michael Benson, Mina M Fam
Agent Orange is an herbicide sprayed widely in Vietnam that is linked to a variety of malignancies in as early as 1991.Since then, there has been concern for, and subsequent interest in studying, the potential connection between Agent Orange and other malignancies. In the past 2 decades, there have been significant changes in the opinion of the National Academy of Science regarding Agent Orange and certain genitourinary malignancies. Herein, we review the literature regarding the potential link between Agent Orange and various urological cancers, including prostate, bladder, testicular, and renal cancers...
September 22, 2017: Urologic Oncology
Angela Fadda, Antonio Barberis, Daniele Sanna
The Fenton reaction is used to produce hydroxyl radicals for the evaluation of the antioxidant activity of plant extracts. In this paper the parameters affecting the production of hydroxyl radicals and their spin trapping with DMPO were studied. The use of quinolinic acid (Quin) as an Fe(II) ligand was proposed for antioxidant activity determination of Green tea, orange juice and asparagus extracts. Quin, buffers and pH affect the DMPO-OH signal intensity of the EPR spectra. Quin/Fe(II) and low pH enhance the OH generation...
February 1, 2018: Food Chemistry
Charles Maynard, Adam Batten, Chuan-Fen Liu, Karin Nelson, Stephan D Fihn
BACKGROUND: Little is known about how Veterans with service-connected conditions use health care provided by the Veterans Health Administration (VHA). OBJECTIVES: To ascertain what proportion of Veterans with service-connected conditions used VHA health care and whether it varied according to type of condition, combined disability rating, age, sex, military rank, or other characteristics and whether there were differences in receipt of inpatient and outpatient care...
November 2017: Medical Care
Hongbo Xia, Suli Wu, Jiajie Bi, Shufen Zhang
Here a simple and effective method was explored to fabricate M/TiO<sub>2</sub> (M=Ag, Au) composites, which required neither pre-treatment of TiO<sub>2</sub> nor any additives as reducing agent. Using amorphous TiO<sub>2</sub> spheres functionalized with SH groups as starting materials, the noble metallic ions (Ag, Au) can be adsorbed by TiO<sub>2</sub> due to their special affinity with SH groups, which is beneficial to the uniform dispersion of metallic ions on the surface of TiO<sub>2</sub>...
September 19, 2017: Nanotechnology
Legna Colina-Vegas, Liany Luna-Dulcey, Ana M Plutín, Eduardo E Castellano, Marcia R Cominetti, Alzir A Batista
Organometallic ruthenium complexes as potential anticancer agents have been explored due to their suitable properties, such as stability in the solid state and in solution, water solubility and low toxicity. In this study, eight metal complexes of this class were synthesized, characterized and their important biological activities against a human breast tumor cell line (MDA-MB-231) were studied. Complexes 1-8 were obtained in good yields and have been characterized by satisfactory elemental analyses, IR, 1D and 2D (1)H and (13)C{(1)H} NMR, UV-Vis spectroscopy, cyclic voltammetry, ESI-MS and X-ray diffractometry (1, 2, 3 and 6)...
October 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Fayaz Ali, Sher Bahadar Khan, Tahseen Kamal, Yasir Anwar, Khalid A Alamry, Abdullah M Asiri
Nanoparticles were synthesized on the surface of green nanocomposite based on carbon black dispersed in chitosan (CB-CS) fibres. The nanoparticles were monometallic Co, Ag and Cu and bimetallic Co + Cu and Co + Ag. The CB-CS fibres were prepared and introduced into separate metal salt solutions containing Co(2+), Ag(+) and Cu(2+) and mixed Co(2+)+Cu(2+) and Co(2+)+Ag(+) ions. The metal ions immobilized on the surface of CB-CS were reduced using sodium borohydride (NaBH4) as reducing agent to synthesize the corresponding zero-valent metal nanoparticles-loaded CB-CS fibres...
August 28, 2017: Chemosphere
Xinan Huang, Sohail Anjum Shahzad, Yongxin Li, Yunyi Zhang, Lijia Sang, Huipeng Zhou, Hong Jiang, Kenneth Kam-Wing Lo, Cong Yu
A novel and efficient approach has been established for the synthesis of silver nanoclusters capped silica nanoparticles (SiO2@AgNCs). These nanoclusters (AgNCs) capped silica nanoparticles were utilized as a novel ratiometric photoluminescence (PL) nanosensor for extremely sensitive and selective detection of I(-) and S(2-) ions. The AgNCs were prepared in situ on the silica nanoparticles through polyethyleneimine (PEI) template approach. While dual PL emissions of AgNCs (at 500 nm) and luminescent silica nanoparticles (at 602 nm) formed the basis for the ratiometric sensing...
October 2, 2017: Analytica Chimica Acta
Ahmad B Albadarin, Samuel Solomon, Tonni Agustiono Kurniawan, Chirangano Mangwandi, Gavin Walker
Novel and low cost chemically modified masau stone (CMMS) was investigated for its biosorption of an anionic azo dye, Orange II (OII), and toxic hexavalent chromium (Cr(VI)) from aqueous systems: individually, simultaneously and consecutively. XPS and FTIR analyses indicated the introduction of quaternary-Nitrogen to the CMMS surface after activation with epichlorohydrin (etherifying agent) and diethylenetriamine (crosslinking agent). The effects of pH, contact time and initial concentration (Co), and loading order on mechanisms of biosorption/reduction of OII and Cr(VI) onto CMMS were examined in detail...
December 15, 2017: Journal of Environmental Management
Craig Mescher, David Gilbertson, Nicole M Randall, Gobind Tarchand, Julie Tomaska, Lisa Baumann Kreuziger, Vicki A Morrison
Exposure to Agent Orange (AO) has been associated with the development of chronic lymphocytic leukemia (CLL). We performed a retrospective study of 2052 Vietnam veterans identified in the National VA Tumor Registry to assess the impact of AO exposure on CLL prognosis, treatment and survival. Prognostic factors did not differ based on exposure. Veterans exposed to AO were diagnosed younger (63.2 vs. 70.5 years, p < .0001) and had longer overall survival (median not reached vs. 91 months, p < .001)...
September 14, 2017: Leukemia & Lymphoma
Kyriakos Kaderides, Athanasia M Goula
The replacement of maltodextrins as carriers for the spray drying of sticky and sugar based bioactives is an important development for the food industry. In this work, orange juice industry by-product was used to obtain a high dietary fiber powder to be used as carrier material. This powder was characterized with respect to its physical and chemical properties related to the process of encapsulation by spray drying. Adsorption isotherms of orange waste powder were determined at 30, 45, and 60°C. The data were fitted to several models including two-parameter (BET, Halsey, Smith, and Oswin), three-parameter (GAB), and four-parameter (Peleg) relationships...
October 2017: Food Research International
Piotr Nockowski, Zdzisław Woźniak, Adam Reich, Joanna Maj
Dear Editor, An 83-year-old woman developed yellow-brownish infiltrates, nodules, and tumors mimicking xanthomas, mostly involving the periorbital and chest area within three months (Figure 1). She had no abnormalities in serum cholesterol or triglycerides levels. A detailed laboratory analysis revealed the presence of mild monoclonal gammopathy with a presence of immunoglobulin G (IgG) kappa light chains; however, according to hematologist consultation, it did not require medical intervention. Imaging assessment and ultrasound examination did not show any specific involvement of internal organs...
July 2017: Acta Dermatovenerologica Croatica: ADC
Cicero Diego Almino Menezes, Francisca Adilfa de Oliveira Garcia, Glauce Socorro de Barros Viana, Patricia Gonçalves Pinheiro, Cícero Francisco Bezerra Felipe, Thaís Rodrigues de Albuquerque, Alisson Cordeiro Moreira, Enaide Soares Santos, Maynara Rodrigues Cavalcante, Tatiana Rodrigues Garcia, Thiago Fonseca Silva, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Orange jasmine, Murraya paniculata (Rutaceae), is a plant from India widely used in folk medicine as antinociceptive, antiinflammatory, and antioxidant. Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic complications. Alloxan-induced diabetic rats were treated for 60 days with a hydroalcoholic extract of M. paniculata (MPE), at doses of 100, 200, and 400 mg/kg...
August 25, 2017: Phytotherapy Research: PTR
Matthew Mossanen, Adam S Kibel, Rose H Goldman
BACKGROUND: During the Vietnam War, many veterans were exposed to Agent Orange (AO), a chemical defoliant containing varying levels of the carcinogen dioxin. The health effects of AO exposure have been widely studied in the VA population. Here we review and interpret data regarding the association between AO exposure and bladder cancer (BC) mortality. MAIN FINDINGS: Data evaluating the association between AO and BC is limited. Methods characterizing exposure have become more sophisticated over time...
August 17, 2017: Urologic Oncology
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