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https://www.readbyqxmd.com/read/27908921/wartime-toxin-exposure-recognising-the-silent-killer
#1
Kamran Khan, Susan E Wozniak, JoAnn Coleman, Mukund S Didolkar
Wartime toxin exposures have been implicated in the genesis of malignancy in war veterans. Agent Orange, one toxin among many, has been linked to malignancy and the subcomponent phenoxyacetic acid has been associated with soft tissue sarcomas (STSs). This case demonstrates the association between a wartime toxin exposure (Agent Orange) and subsequent cancer development. Ultimately, we aim to highlight the importance of simple, specific questions in the patient history to account for previous wartime toxin exposures...
December 1, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27891561/citrus-psorosis-virus-coat-protein-derived-hairpin-construct-confers-stable-transgenic-resistance-in-citrus-against-psorosis-a-and-b-syndromes
#2
A De Francesco, N Costa, M L García
Citrus psorosis virus (CPsV) is the causal agent of psorosis, a serious and widespread citrus disease. Two syndromes of psorosis, PsA and PsB, have been described. PsB is the most aggressive and rampant form. Previously, we obtained Pineapple sweet orange plants transformed with a hairpin construct derived from the CPsV coat protein gene (ihpCP). Some of these plants were resistant to CPsV 90-1-1, a PsA isolate homologous to the transgene. In this study, we found that expression of the ihpCP transgene and siRNA production in lines ihpCP-10 and -15 were stable with time and propagation...
November 28, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27891240/differences-in-the-clinical-manifestations-and-short-term-prognosis-of-acute-cerebral-infarction-after-exposure-to-agent-orange
#3
SangWoo Han, Inha Hwang, Seung Min Kim, Young Soon Yang, SangWon Ha, Jeong Ho Han, Tae Hwan Park
BACKGROUND: Agent Orange (AO) is the code name for one of the herbicides and defoliants used in the Vietnam War. Studies conducted thus far show a significant correlation between AO and the occurrence of cardiovascular diseases. But there is little data on the association between AO and stroke, and limited studies have targeted patient groups exposed to AO. METHOD: Bohun medical center Institutional Review Board (IRB) approved the study. (ID: 341) We studied patients with acute ischemic stroke within 7 days of onset in VHS medical center and 4 other general hospitals...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27889234/in-silico-and-in-vitro-anti-cancer-potential-of-a-curcumin-analogue-1e-6e-1-7-di-1h-indol-3-yl-hepta-1-6-diene-3-5-dione
#4
Shamim Akhtar Sufi, Lakshmi Narayana Adigopula, Safiulla Basha Syed, Victor Mukherjee, Mohane S Coumar, H Surya Prakash Rao, Rukkumani Rajagopalan
PURPOSE: Previously we showed that BDMC, an analogue of curcumin suppresses growth of human breast and laryngeal cancer cell line by causing apoptosis. Here, we demonstrate the enhanced anti-cancer activity of a heterocyclic ring (indole) incorporated curcumin analogue ((1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-Dione), ICA in short, in comparison to curcumin. METHOD: ICA was synthesized by a one pot condensation reaction. Anti-cancer potential of ICA was assessed in three human cancer cell lines of different origin (Lung adenocarcinoma (A549), leukemia (K562) and colon cancer (SW480)) by MTT assay...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27885775/the-coffee-leaf-rust-pathogen-hemileia-vastatrix-one-and-a-half-centuries-around-the-tropics
#5
Pedro Talhinhas, Dora Batista, Inês Diniz, Ana Vieira, Diogo N Silva, Andreia Loureiro, Sílvia Tavares, Ana Paula Pereira, Helena G Azinheira, Leonor Guerra-Guimarães, Vítor Várzea, Maria do Céu Silva
Taxonomy and history: Hemileia vastatrix Berk. and Broome (Basidiomycota, Pucciniales) was described in 1869 in Eastern Africa and Ceylon as the agent of Coffee Leaf Rust and spread to all coffee cultivation areas worldwide. Major disease outbreaks in Asia, Africa and America caused and continue to cause severe yield losses, making this the most important disease of Arabica coffee, a cash crop for many tropical and sub-tropical countries. Life cycle and disease symptoms: Hemileia vastatrix is a hemicyclic fungus with the urediniosporic life cycle as its most important (if not only) source of inoculum...
November 25, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27879007/drotaverine-a-concealed-cytostatic
#6
Ioana Z Pavel, Lucie Heller, Sven Sommerwerk, Anne Loesche, Ahmed Al-Harrasi, René Csuk
Drotaverine (also known as dihydroperparine or No-Spa(®) ) is an antispasmodic drug closely related to papaverin. Drotaverin also acts as a cytostatic compound for several human tumor cell lines and nonmalignant mouse fibroblasts, and EC50 values as low as 3.0 μM were observed in SRB assays for HT-29 human colorectal carcinoma cells. Small structural changes (e.g., aromatization, benzylic oxidation) led to a reduced activity or a complete loss of cytotoxicity. Staining of the cells with acridine orange showed the cell membrane of the dead cells to be still intact, and a slight G1/G0 arrest in the treated cells was observed after 24 h...
November 23, 2016: Archiv der Pharmazie
https://www.readbyqxmd.com/read/27870949/green-synthesis-of-pd-nanoparticles-at-apricot-kernel-shell-substrate-using-salvia-hydrangea-extract-catalytic-activity-for-reduction-of-organic-dyes
#7
Bahar Khodadadi, Maryam Bordbar, Mahmoud Nasrollahzadeh
For the first time the extract of the plant of Salvia hydrangea was used to green synthesis of Pd nanoparticles (NPs) supported on Apricot kernel shell as an environmentally benign support. The Pd NPs/Apricot kernel shell as an effective catalyst was prepared through reduction of Pd(2+) ions using Salvia hydrangea extract as the reducing and capping agent and Pd NPs immobilization on Apricot kernel shell surface in the absence of any stabilizer or surfactant. According to FT-IR analysis, the hydroxyl groups of phenolics in Salvia hydrangea extract as bioreductant agents are directly responsible for the reduction of Pd(2+) ions and formation of Pd NPs...
November 9, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27860301/synthesis-and-biological-evaluation-of-novel-imidazopyrimidin-3-amines-as-anticancer-agents
#8
Mohammad Mahdavi, Shima Dianat, Behnaz Khavari, Setareh Moghimi, Mohammad Abdollahi, Maliheh Safavi, Arash Mouradzadegun, Susan Kabodian-Ardestani, Reyhaneh Sabourian, Saeed Emami, Tahmineh Akbarzadeh, Abbas Shafiee, Alireza Foroumadi
Groebke-Blackburn-Bienayme reaction (GBB) has been utilized for the synthesis of new imidazo[1,2-a]pyrimidine derivatives as novel anticancer agents. The cytotoxic activities of compounds were evaluated against human cancer cell lines including MCF-7, T-47D and MDA-MB-231, compared with etoposide as the standard drug. Among the tested compounds, hydroxy- and/or methoxy-phenyl derivatives (6a-c and 6k) with IC50 values of 6.72-14.36 μM were more potent than etoposide against all cell lines. The acridine-orange/ethidium bromide double staining and DNA-fragmentation studies demonstrated that the cytotoxic effect of 3-hydroxy-4-methoxyphenyl derivative 6c is associated with apoptosis in cancer cells...
November 8, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27846986/colorimetric-detection-of-hydrogen-peroxide-and-lactate-based-on-the-etching-of-the-carbon-based-au-ag-bimetallic-nanocomposite-synthesized-by-carbon-dots-as-the-reductant-and-stabilizer
#9
Lin Zhang, Wenli Hou, Qiujun Lu, Meiling Liu, Chao Chen, Youyu Zhang, Shouzhuo Yao
In this report, carbon-based gold core silver shell Au-Ag bimetallic nanocomposite (Au-Ag/C NC) was synthesized using carbon dots (C-dots) as the reductant and stabilizer by a facile green sequential reduction approach. The structure and morphology of the nanocomposite are characterized by ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR) and transmission electron microscopy (TEM). The as synthesized Au-Ag/C NC exhibits good optic response toward hydrogen peroxide (H2O2) without adding any other chromogenic agents...
December 1, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27843913/quercetin-as-an-emerging-anti-melanoma-agent-a-four-focus-area-therapeutic-development-strategy
#10
REVIEW
Zoey Harris, Micah G Donovan, Gisele Morais Branco, Kirsten H Limesand, Randy Burd
Replacing current refractory treatments for melanoma with new prevention and therapeutic approaches is crucial in order to successfully treat this aggressive cancer form. Melanoma develops from neural crest cells, which express tyrosinase - a key enzyme in the pigmentation pathway. The tyrosinase enzyme is highly active in melanoma cells and metabolizes polyphenolic compounds; tyrosinase expression thus makes feasible a target for polyphenol-based therapies. For example, quercetin (3,3',4',5,7-pentahydroxyflavone) is a highly ubiquitous and well-classified dietary polyphenol found in various fruits, vegetables, and other plant products including onions, broccoli, kale, oranges, blueberries, apples, and tea...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27823624/antitumor-lignanamides-from-the-aerial-parts-of-corydalis-saxicola
#11
Bin Zhang, Rizhen Huang, Jing Hua, Hong Liang, Yingming Pan, Lumei Dai, Dong Liang, Hengshan Wang
BACKGROUND: Cancer is one of the leading cause of unnatural death globally. There is still a great need for effective anticancer agents from plant sources. Corydalis saxicola Bunting is a medicinal plant that is traditionally used to treat various diseases in southwest China. Previous phytochemical investigations of C. saxicola have focused on isoquinoline alkaloids that have been isolated, which have activity against anti-hepatitis B virus and inhibit DNA topoisomerase I. However, the exploration of other classes of constituents and their bioactivities needs further study...
December 1, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27818862/kinetic-study-of-a-%C3%AE-mannanase-from-the-bacillus-licheniformis-hdym-04-and-its-decolorization-ability-of-twenty-two-structurally-different-dyes
#12
Jingping Ge, Renpeng Du, Dan Zhao, Gang Song, Man Jin, Wenxiang Ping
BACKGROUND: The microbial β-mannanases have been increasingly exploited for bioconversion of biomass materials and various potential industrial applications, such as bleaching of softwood pulps, scouring and desizing, food and feed additive, and oil and textile industries. In this paper, a β-mannanase was characterization from the bacteria, Bacillus licheniformis HDYM-04, which was a high β-mannanase-producing strain (576.16 ± 2.12 U/mL at 48 h during fermentation). METHODS: The michaelis constant (Km ) and maximum velocity (Vmax ) of β-mannanase were determined...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27818836/application-of-cerium-iv-as-an-oxidimetric-agent-for-the-determination-of-ethionamide-in-pharmaceutical-formulations
#13
Kanakapura Basavaiah, Nagib A S Qarah, Sameer A M Abdulrahman
Two simple methods are described for the determination of ethionamide (ETM) in bulk drug and tablets using cerium (IV) sulphate as the oxidimetric agent. In both methods, the sample solution is treated with a measured excess of cerium (IV) solution in H2SO4 medium, and after a fixed standing time, the residual oxidant is determined either by back titration with standard iron (II) solution to a ferroin end point in titrimetry or by reacting with o-dianisidine followed by measurement of the absorbance of the orange-red coloured product at 470 nm in spectrophotometry...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27816988/potential-role-of-exoglucanase-genes-waexg1-and-waexg2-in-the-biocontrol-activity-of-wickerhamomyces-anomalus
#14
Lucia Parafati, Gabriella Cirvilleri, Cristina Restuccia, Michael Wisniewski
The use of yeasts, including Wickerhamomyces anomalus, as biocontrol agents of fungi responsible for postharvest diseases of fruits and vegetables has been investigated for the past two decades. Among a variety of mechanisms, the production of glucanases coded by the "killer genes" WaEXG1 and WaEXG2 have been reported to play a role in the ability of yeast to inhibit other fungi. The objective of the present study was to determine the expression of these genes by RT-qPCR, utilizing gene-specific primers, when W...
November 5, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27816916/limited-evidence-for-rickettsia-felis-as-a-cause-of-zoonotic-flea-borne-rickettsiosis-in-southern-california
#15
Sarah A Billeter, Marco E Metzger
Over 90% of human flea-borne rickettsioses cases in California are reported from suburban communities of Los Angeles and Orange counties and are presumed to be associated with either Rickettsia typhi or Rickettsia felis infection. Ctenocephalides felis (Bouché) is considered the principal vector for both rickettsiae, and R. felis has largely replaced R. typhi as the presumptive etiologic agent based on the widespread incidence of R. felis in cat flea populations. However, with no evidence to confirm R. felis as the cause of human illness in southern California, coupled with recent findings that showed R...
November 4, 2016: Journal of Medical Entomology
https://www.readbyqxmd.com/read/27800481/intraoperative-fluorescence-imaging-for-personalized-brain-tumor-resection-current-state-and-future-directions
#16
REVIEW
Evgenii Belykh, Nikolay L Martirosyan, Kaan Yagmurlu, Eric J Miller, Jennifer M Eschbacher, Mohammadhassan Izadyyazdanabadi, Liudmila A Bardonova, Vadim A Byvaltsev, Peter Nakaji, Mark C Preul
INTRODUCTION: Fluorescence-guided surgery is one of the rapidly emerging methods of surgical "theranostics." In this review, we summarize current fluorescence techniques used in neurosurgical practice for brain tumor patients as well as future applications of recent laboratory and translational studies. METHODS: Review of the literature. RESULTS: A wide spectrum of fluorophores that have been tested for brain surgery is reviewed. Beginning with a fluorescein sodium application in 1948 by Moore, fluorescence-guided brain tumor surgery is either routinely applied in some centers or is under active study in clinical trials...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27797229/oxidative-stress-induced-apoptosis-in-chronic-myelogenous-leukemia-k562-cells-by-an-active-compound-from-the-dithio-carbamate-family
#17
Laya Khoshtabiat, Majid Mahdavi, Gholamreza Dehghan, Mohammad Reza Rashidi
Previous studies suggested that dithio-carbamates are potent apoptosis and anti-apoptosis inducing agents in various cancer cells. Here, the anti-proliferative and apoptosis inducing effects of a new derivative (2-NDC) from the dithio-carbamate family was examined in human leukemia K562 cells. We use thiazolyl blue tetrazolium bromide (MTT) to measure viability and cell growth inhibition. The 2-NDC showed effects on viability in a dose and time-dependent manner, inhibiting proliferation at concentrations of 10-30 μM after 24-48 hours of treatment and increasing values after 72 hours at 40-120 μM...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27779261/experimental-and-theoretical-studies-on-methylene-blue-and-methyl-orange-sorption-by-wheat-straw-derived-biochar-with-a-large-surface-area
#18
Peifang Wang, Chuangfei Wu, Yong Guo, Chao Wang
Wheat straw-derived biochar (BC-4-700) with a large surface area (2263.10 m(2) g(-1)) has been synthesized using potassium hydroxide as an activating agent, and its sorption performance is evaluated by sorbing methylene blue (MB) and methyl orange (MO). The sorption behaviours of both MO and MB by BC-4-700 all follow pseudo-second-order and Langmuir models, and the driving forces for the two sorptions are attributed to the pi-pi interaction. The largest sorption quantity for MO by BC-4-700 is 3.24 mmol g(-1), being 1...
October 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27773706/synthesis-biological-characterization-and-evaluation-of-molecular-mechanisms-of-novel-copper-complexes-as-anticancer-agents
#19
Ceyda Acilan, Buse Cevatemre, Zelal Adiguzel, Didem Karakas, Engin Ulukaya, Nádia Ribeiro, Isabel Correia, João Costa Pessoa
BACKGROUND: To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based compounds. Here, three Cu(II)-complexes, Cu(Sal-Gly)(phen), Cu(Sal-Gly)(pheamine), Cu(Sal-Gly)(phepoxy) are characterized for their interaction with DNA, cytotoxicity and mechanism of action. METHODS: The binding ability of the complexes to Calf-Thymus DNA was evaluated by competition fluorescence studies with thiazole-orange, UV-Vis and circular dichroism spectroscopic titrations...
October 20, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27771936/auraptene-and-its-role-in-chronic-diseases
#20
Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar
Auraptene (7-geranyloxycoumarin) is the best known and most abundant prenyloxycoumarin present in nature. It is synthesized by various plant species, mainly those of the Rutaceae and Umbeliferae (Apiaceae) families, comprising many edible fruits and vegetables such as lemons, grapefruit and orange. Auraptene has shown a remarkable effect in the prevention of degenerative diseases, in particular it has been reported to be one the most promising known natural chemopreventive agents against several types of cancer...
2016: Advances in Experimental Medicine and Biology
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