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https://www.readbyqxmd.com/read/28070070/quantitative-determination-of-iron-ions-based-on-a-resonance-raman-rr-probe-phenanthroline
#1
Liang Wang, Yi Zhang, Yeonju Park, Lei Chen, Young Mee Jung
In this paper, we demonstrate a new promising resonance Raman (RR)-based method for the determination of Fe(3+) concentrations in aqueous solutions. Iron ions were quantified at a low concentration range by employing hydroxylamine hydrochloride as the reductant, and phenanthroline as the complexing agent, thereby reducing Fe(3+) to Fe(2+). The addition of Fe(3+) to the detection reagent resulted in a rapid color change from colorless to orange-red, together with an obvious new RR band appearing at 1459 cm(-1)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28068602/synthesis-of-2-3-6-7-tetramethoxyphenanthren-9-amine-an-efficient-precursor-to-access-new-4-aza-2-3-dihydropyridophenanthrenes-as-apoptosis-inducing-agents
#2
Niggula Praveen Kumar, Pankaj Sharma, T Srinivasa Reddy, Shalini Nekkanti, Nagula Shankaraiah, Guntuku Lalita, S Sujanakumari, Suresh K Bhargava, V G M Naidu, Ahmed Kamal
A new route for the synthesis of novel 2,3,6,7-tetramethoxy phenanthrene amine precursor has been successfully accomplished. Subsequently, this amine precursor has been directly utilized for the synthesis of a new series of 4-aza-2,3-dihydropyridophenanthrene derivatives via a three component reaction with tetronic acid and substituted aldehydes. These compounds were evaluated for their cytotoxic potential against human lung (A549), prostate (PC-3 and DU145), breast (MDA-MB-231 and 4T1), gastric (HGC-27), colon (Caco-2) and cervical (HeLa) cancer cell lines...
January 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28066114/antigenotoxic-and-apoptotic-activities-of-essential-oil-of-atalantia-monophylla-correa
#3
Ramaraj Thirugnanasampandan, Gunasekar Ramya, Madusudhanan Gogulramnath
OBJECTIVE: To study antigenotoxic and apoptotic activities of hydrodistilled essential oil from the leaves of Atalantia monophylla Correa. MATERIALS AND METHODS: Antigenotoxic activity of essential oil was tested against hydrogen peroxide (100 μM)-induced deoxyribonucleic acid (DNA) damage in 3T3-L1 cells. Cervical cancer cell (HeLa) growth inhibitory effect of essential oil was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay. Annexin V-fluorescein isothiocyanate/propidium iodide (FITC/PI), Hoechst 33258, and acridine orange/ethidium bromide (AO/EtBr) staining techniques were used to identify apoptosis...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28040156/potential-of-a-new-strain-of-bacillus-amyloliquefaciens-buz-14-as-a-biocontrol-agent-of-postharvest-fruit-diseases
#4
H Calvo, P Marco, D Blanco, R Oria, M E Venturini
The biocontrol potential of the Bacillus amyloliquefaciens strain BUZ-14 was tested against the main postharvest diseases of orange, apple, grape and stone fruit. After characterizing the temperature and pH growth curves of strain BUZ-14, its in vitro antifungal activity was determined against Botrytis cinerea, Monilinia fructicola, M. laxa, Penicillium digitatum, P. expansum and P. italicum. Subsequently, in vivo activity was tested against these pathogens by treating fruit with cells, endospores and cell-free supernatants...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28038323/synthesis-and-biological-evaluation-of-curcumin-inspired-indole-analogues-as-tubulin-polymerization-inhibitors
#5
P V Sri Ramya, Srinivas Angapelly, Lalita Guntuku, Chander Singh Digwal, Bathini Nagendra Babu, V G M Naidu, Ahmed Kamal
In our endeavour towards the development of potent cytotoxic agents, a series of some new curcumin inspired indole analogues, in which indole and phenyl moieties are linked on either sides of 1,5-diaryl-1,4-pentadien-3-one system have been synthesized and characterized by spectral data. All the newly synthesized analogues were tested for their cytotoxic potential against a panel of eight cancer cell lines namely, lung (A549), breast (MDA-MB-231, BT549 and 4T1), prostate (PC-3, DU145), gastric (HGC-27) and cervical (HeLa)...
December 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28035421/digitoxin-synergizes-with-sorafenib-to-inhibit-hepatocelluar-carcinoma-cell-growth-without-inhibiting-cell-migration
#6
Yijun Xiao, Wei Yan, Libin Guo, Chen Meng, Bin Li, Henrique Neves, Peng-Chen Chen, Ling Li, Yide Huang, Hang Fai Kwok, Yao Lin
Sorafenib is a chemotherapeutic agent approved for the treatment of hepatocellular carcinoma (HCC) in China. Digitoxin is a cardiotonic drug, which has been demonstrated to exhibit anticancer effects in a number of cancers, but not in HCC. The aim of the present study was to evaluate the combinational effect of sorafenib and digitoxin on the treatment of HCC and to investigate the relevant molecular mechanisms of action that underlie these effects. The proliferation, cell death and migration of HCC cell lines, HepG2 and BEL‑7402, were examined using MTT, acridine orange/ethidium bromide staining and scratch wound healing assays, respectively...
December 30, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27980993/all-copper-nanocluster-based-down-conversion-white-light-emitting-devices
#7
Zhenguang Wang, Bingkun Chen, Andrei S Susha, Weihua Wang, Claas J Reckmeier, Rui Chen, Haizheng Zhong, Andrey L Rogach
Most of the present-day down-conversion white light-emitting devices (WLEDs) utilize rare-earth elements, which are expensive and facing the problem of shortage in supply. WLEDs based on the combination of orange and blue emitting copper nanoclusters are introduced, which are easy to produce and low in cost. Orange emitting Cu nanoclusters (NCs) are synthesized using glutathione as both the reduction agent and stabilizer, followed by solvent induced aggregation leading to the emission enhancement. Photoluminescence quantum yields (PL QY) of 24% and 43% in solution and solid state are achieved, respectively...
November 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27978441/development-of-horseradish-peroxidase-based-cross-linked-enzyme-aggregates-and-their-environmental-exploitation-for-bioremediation-purposes
#8
Muhammad Bilal, Hafiz M N Iqbal, Hongbo Hu, Wei Wang, Xuehong Zhang
In the present study, horseradish peroxidase (HRP), in-house isolated crude cocktail enzyme, from Armoracia rusticana was cross-linked using a new type of cross-linking agent, i.e., ethylene glycol-bis [succinic acid N-hydroxysuccinimide, (EG-NHS)], which is mild in nature as compared to the glutaraldehyde (GA). The HRP-immobilized cross-linked enzyme aggregates (HRP-CLEAs) were developed using a wider range of EG-NHS and notably no adverse effect was observed. In a comparative evaluation, in the case of EG-NHS, a high-level stability in the residual activity was recorded, whereas a sharp decrease was observed in the case of glutaraldehyde...
March 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27965050/the-optimal-dose-of-arsenic-trioxide-induced-opposite-efficacy-in-autophagy-between-k562-cells-and-their-initiating-cells-to-eradicate-human-myelogenous-leukemia
#9
Zhenzhen Guo, Mingjing Meng, Shengnan Geng, Zhenhua Du, Yaqiu Zheng, Jingjing Yao, Zibo Li, Guang Han, Haihong Lin, Gangjun Du
ETHNOPHARMACOLOGICAL RELEVANCE: Arsenic trioxide (As2O3), a main component of arsenolite which is a common traditional Chinese medicine (TCM) wildly used as a therapeutic agent for more than 2400 years in china, has been accepted as a standard treatment for the patients with acute promyelocytic leukemia (APL) based on the principle in TCM of "using a poison to fight against other poisons or malignancy illnesses". However, it remains unknown that which mechanism is actually responsible for the therapeutic effects against these blood malignancies...
December 10, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27941926/dihydroartemisinin-inhibits-catabolism-in-rat-chondrocytes-by-activating-autophagy-via-inhibition-of-the-nf-%C3%AE%C2%BAb-pathway
#10
Li-Bo Jiang, De-Hua Meng, Soo-Min Lee, Shu-Hao Liu, Qin-Tong Xu, Yang Wang, Jian Zhang
Osteoarthritis is a disease with inflammatory and catabolic imbalance in cartilage. Dihydroartemisinin (DHA), a natural and safe anti-malarial agent, has been reported to inhibit inflammation, but its effects on chondrocytes have yet to be elucidated. We investigated the effects of DHA on catabolism in chondrocytes. Viability of SD rats chondrocytes was analyzed. Autophagy levels were determined via expression of autophagic markers LC3 and ATG5, GFP-LC3 analysis, acridine orange staining, and electron microscopy...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27938950/pterygium-excision-with-conjunctival-autograft-and-subconjunctival-amniotic-membrane-as-antirecurrence-agents
#11
Alexander Shusko, John A Hovanesian
OBJECTIVE: To determine the outcome of pterygium excision with a conjunctival autograft when the adjunctive use of a subconjunctival graft of amniotic membrane is employed to reduce fibrosis and recurrence after surgery. DESIGN: This is a retrospective, noncomparative study of postoperative outcomes. PARTICIPANTS: Eighty-four patients totalling 101 eyes with clinically significant pterygia that warranted surgical excision. METHODS: Surgeries were performed at South Orange County Outpatient Surgery Center (San Clemente, Calif...
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27908921/wartime-toxin-exposure-recognising-the-silent-killer
#12
Kamran Khan, Susan E Wozniak, JoAnn Coleman, Mukund S Didolkar
Wartime toxin exposures have been implicated in the genesis of malignancy in war veterans. Agent Orange, one toxin among many, has been linked to malignancy and the subcomponent phenoxyacetic acid has been associated with soft tissue sarcomas (STSs). This case demonstrates the association between a wartime toxin exposure (Agent Orange) and subsequent cancer development. Ultimately, we aim to highlight the importance of simple, specific questions in the patient history to account for previous wartime toxin exposures...
December 1, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27891561/citrus-psorosis-virus-coat-protein-derived-hairpin-construct-confers-stable-transgenic-resistance-in-citrus-against-psorosis-a-and-b-syndromes
#13
A De Francesco, N Costa, M L García
Citrus psorosis virus (CPsV) is the causal agent of psorosis, a serious and widespread citrus disease. Two syndromes of psorosis, PsA and PsB, have been described. PsB is the most aggressive and rampant form. Previously, we obtained Pineapple sweet orange plants transformed with a hairpin construct derived from the CPsV coat protein gene (ihpCP). Some of these plants were resistant to CPsV 90-1-1, a PsA isolate homologous to the transgene. In this study, we found that expression of the ihpCP transgene and siRNA production in lines ihpCP-10 and -15 were stable with time and propagation...
November 28, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27891240/differences-in-the-clinical-manifestations-and-short-term-prognosis-of-acute-cerebral-infarction-after-exposure-to-agent-orange
#14
SangWoo Han, Inha Hwang, Seung Min Kim, Young Soon Yang, SangWon Ha, Jeong Ho Han, Tae Hwan Park
BACKGROUND: Agent Orange (AO) is the code name for one of the herbicides and defoliants used in the Vietnam War. Studies conducted thus far show a significant correlation between AO and the occurrence of cardiovascular diseases. But there is little data on the association between AO and stroke, and limited studies have targeted patient groups exposed to AO. METHOD: Bohun medical center Institutional Review Board (IRB) approved the study. (ID: 341) We studied patients with acute ischemic stroke within 7 days of onset in VHS medical center and 4 other general hospitals...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27889234/in-silico-and-in-vitro-anti-cancer-potential-of-a-curcumin-analogue-1e-6e-1-7-di-1h-indol-3-yl-hepta-1-6-diene-3-5-dione
#15
Shamim Akhtar Sufi, Lakshmi Narayana Adigopula, Safiulla Basha Syed, Victor Mukherjee, Mohane S Coumar, H Surya Prakash Rao, Rukkumani Rajagopalan
PURPOSE: Previously we showed that BDMC, an analogue of curcumin suppresses growth of human breast and laryngeal cancer cell line by causing apoptosis. Here, we demonstrate the enhanced anti-cancer activity of a heterocyclic ring (indole) incorporated curcumin analogue ((1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-Dione), ICA in short, in comparison to curcumin. METHOD: ICA was synthesized by a one pot condensation reaction. Anti-cancer potential of ICA was assessed in three human cancer cell lines of different origin (Lung adenocarcinoma (A549), leukemia (K562) and colon cancer (SW480)) by MTT assay...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27885775/the-coffee-leaf-rust-pathogen-hemileia-vastatrix-one-and-a-half-centuries-around-the-tropics
#16
Pedro Talhinhas, Dora Batista, Inês Diniz, Ana Vieira, Diogo N Silva, Andreia Loureiro, Sílvia Tavares, Ana Paula Pereira, Helena G Azinheira, Leonor Guerra-Guimarães, Vítor Várzea, Maria do Céu Silva
Taxonomy and history: Hemileia vastatrix Berk. and Broome (Basidiomycota, Pucciniales) was described in 1869 in Eastern Africa and Ceylon as the agent of Coffee Leaf Rust and spread to all coffee cultivation areas worldwide. Major disease outbreaks in Asia, Africa and America caused and continue to cause severe yield losses, making this the most important disease of Arabica coffee, a cash crop for many tropical and sub-tropical countries. Life cycle and disease symptoms: Hemileia vastatrix is a hemicyclic fungus with the urediniosporic life cycle as its most important (if not only) source of inoculum...
November 25, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27879007/drotaverine-a-concealed-cytostatic
#17
Ioana Z Pavel, Lucie Heller, Sven Sommerwerk, Anne Loesche, Ahmed Al-Harrasi, René Csuk
Drotaverine (also known as dihydroperparine or No-Spa(®) ) is an antispasmodic drug closely related to papaverin. Drotaverin also acts as a cytostatic compound for several human tumor cell lines and nonmalignant mouse fibroblasts, and EC50 values as low as 3.0 μM were observed in SRB assays for HT-29 human colorectal carcinoma cells. Small structural changes (e.g., aromatization, benzylic oxidation) led to a reduced activity or a complete loss of cytotoxicity. Staining of the cells with acridine orange showed the cell membrane of the dead cells to be still intact, and a slight G1/G0 arrest in the treated cells was observed after 24 h...
November 23, 2016: Archiv der Pharmazie
https://www.readbyqxmd.com/read/27870949/green-synthesis-of-pd-nanoparticles-at-apricot-kernel-shell-substrate-using-salvia-hydrangea-extract-catalytic-activity-for-reduction-of-organic-dyes
#18
Bahar Khodadadi, Maryam Bordbar, Mahmoud Nasrollahzadeh
For the first time the extract of the plant of Salvia hydrangea was used to green synthesis of Pd nanoparticles (NPs) supported on Apricot kernel shell as an environmentally benign support. The Pd NPs/Apricot kernel shell as an effective catalyst was prepared through reduction of Pd(2+) ions using Salvia hydrangea extract as the reducing and capping agent and Pd NPs immobilization on Apricot kernel shell surface in the absence of any stabilizer or surfactant. According to FT-IR analysis, the hydroxyl groups of phenolics in Salvia hydrangea extract as bioreductant agents are directly responsible for the reduction of Pd(2+) ions and formation of Pd NPs...
November 9, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27860301/synthesis-and-biological-evaluation-of-novel-imidazopyrimidin-3-amines-as-anticancer-agents
#19
Mohammad Mahdavi, Shima Dianat, Behnaz Khavari, Setareh Moghimi, Mohammad Abdollahi, Maliheh Safavi, Arash Mouradzadegun, Sussan Kabudanian Ardestani, Reyhaneh Sabourian, Saeed Emami, Tahmineh Akbarzadeh, Abbas Shafiee, Alireza Foroumadi
Groebke-Blackburn-Bienayme reaction has been utilized for the synthesis of new imidazo[1,2-a]pyrimidine derivatives as novel anticancer agents. The cytotoxic activities of compounds were evaluated against human cancer cell lines including MCF-7, T-47D, and MDA-MB-231, compared with etoposide as the standard drug. Among the tested compounds, hydroxy- and/or methoxy-phenyl derivatives (6a-c and 6k) with IC50 values of 6.72-14.36 μm were more potent than etoposide against all cell lines. The acridine orange/ethidium bromide double staining and DNA fragmentation studies demonstrated that the cytotoxic effect of 3-hydroxy-4-methoxyphenyl derivative 6c is associated with apoptosis in cancer cells...
November 8, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27846986/colorimetric-detection-of-hydrogen-peroxide-and-lactate-based-on-the-etching-of-the-carbon-based-au-ag-bimetallic-nanocomposite-synthesized-by-carbon-dots-as-the-reductant-and-stabilizer
#20
Lin Zhang, Wenli Hou, Qiujun Lu, Meiling Liu, Chao Chen, Youyu Zhang, Shouzhuo Yao
In this report, carbon-based gold core silver shell Au-Ag bimetallic nanocomposite (Au-Ag/C NC) was synthesized using carbon dots (C-dots) as the reductant and stabilizer by a facile green sequential reduction approach. The structure and morphology of the nanocomposite are characterized by ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR) and transmission electron microscopy (TEM). The as synthesized Au-Ag/C NC exhibits good optic response toward hydrogen peroxide (H2O2) without adding any other chromogenic agents...
December 1, 2016: Analytica Chimica Acta
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