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https://www.readbyqxmd.com/read/28208159/two-previously-unknown-phytophthora-species-associated-with-brown-rot-of-pomelo-citrus-grandis-fruits-in-vietnam
#1
Ivana Puglisi, Alessandro De Patrizio, Leonardo Schena, Thomas Jung, Maria Evoli, Antonella Pane, Nguyen Van Hoa, Mai Van Tri, Sandra Wright, Mauritz Ramstedt, Christer Olsson, Roberto Faedda, Gaetano Magnano di San Lio, Santa Olga Cacciola
Two distinct Phytophthora taxa were found to be associated with brown rot of pomelo (Citrus grandis), a new disease of this ancestral Citrus species, in the Vinh Long province, Mekong River Delta area, southern Vietnam. On the basis of morphological characters and using the ITS1-5.8S-ITS2 region of the rDNA and the cytochrome oxidase subunit 1 (COI) as barcode genes, one of the two taxa was provisionally named as Phytophthora sp. prodigiosa, being closely related to but distinct from P. insolita, a species in Phytophthora Clade 9, while the other one, was closely related to but distinct from the Clade 2 species P...
2017: PloS One
https://www.readbyqxmd.com/read/28198956/evaluating-pharmaceutical-waste-disposal-in-pediatric-units
#2
Maria Angélica Randoli de Almeida, Ana Maria Miranda Martins Wilson, Maria Angélica Sorgini Peterlini
OBJECTIVE: To verify the disposal of pharmaceutical waste performed in pediatric units. METHOD: A descriptive and observational study conducted in a university hospital. The convenience sample consisted of pharmaceuticals discarded during the study period. Handling and disposal during preparation and administration were observed. Data collection took place at pre-established times and was performed using a pre-validated instrument. RESULTS: 356 drugs disposals were identified (35...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28194295/preparation-of-tio2-nanotubes-loaded-on-polyurethane-membrane-and-research-on-their-photocatalytic-properties
#3
Longli Lin, Qijun Wu, Xun Gong, Yu Zhang
To solve the problem of separation and recovery of photocatalyst in water, the modification of TiO2 was studied as well as its immobilization and photocatalytic properties. To improve surface properties, TiO2 nanotubes were synthesized by a hydrothermal method and silylated by silane coupling agents to introduce a certain functional group. Supported on polyurethane (PU) membrane, TiO2 nanotubes were prepared to produce immobilized PU/TiO2. Catalysts were characterized and identified by means of Fourier-transform infrared spectroscopy (FTIR), attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), and scanning electron microscopy (SEM)...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28179028/betanodavirus-like-particles-enter-host-cells-via-clathrin-mediated-endocytosis-in-a-cholesterol-ph-and-cytoskeleton-dependent-manner
#4
Runqing Huang, Guohua Zhu, Jing Zhang, Yuxiong Lai, Yu Xu, Jianguo He, Junfeng Xie
Betanodavirus, also referred to nervous necrosis virus (NNV), is the causative agent of the fatal disease, viral nervous necrosis and has brought significant economic losses in marine and freshwater cultured fish, especially larvae and juveniles. Here, we used an established invasion model with virus-like particle (VLP)-cells, mimicking orange-spotted grouper nervous necrosis virus (OGNNV), to investigate the crucial events of virus entry. VLP were observed in the perinuclear regions of Asian sea bass (SB) cells within 1...
February 8, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28155188/inducible-expression-of-bs2-r-gene-from-capsicum-chacoense-in-sweet-orange-citrus-sinensis-l-osbeck-confers-enhanced-resistance-to-citrus-canker-disease
#5
Lorena Noelia Sendín, Ingrid Georgina Orce, Rocío Liliana Gómez, Ramón Enrique, Carlos Froilán Grellet Bournonville, Aldo Sergio Noguera, Adrián Alberto Vojnov, María Rosa Marano, Atilio Pedro Castagnaro, María Paula Filippone
Transgenic expression of the pepper Bs2 gene confers resistance to Xanthomonas campestris pv. vesicatoria (Xcv) pathogenic strains which contain the avrBs2 avirulence gene in susceptible pepper and tomato varieties. The avrBs2 gene is highly conserved among members of the Xanthomonas genus, and the avrBs2 of Xcv shares 96% homology with the avrBs2 of Xanthomonas citri subsp. citri (Xcc), the causal agent of citrus canker disease. A previous study showed that the transient expression of pepper Bs2 in lemon leaves reduced canker formation and induced plant defence mechanisms...
February 2, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28139498/enhanced-efficacy-of-5-fluorouracil-in-combination-with-a-dual-histone-deacetylase-and-phosphatidylinositide-3-kinase-inhibitor-cudc-907-in-colorectal-cancer-cells
#6
Rimi Hamam, Dalia Ali, Radhakrishnan Vishnubalaji, Zaid F Alsaaran, Elna Paul Chalisserry, Musaad Alfayez, Abdullah Aldahmash, Nehad M Alajez
BACKGROUND/AIMS: 5-Fluorouracil (5-FU) is widely used in the treatment of patients with colorectal cancer (CRC). However, the efficacy of 5-FU as a single agent is limited, with multiple undesired side effects. Therefore, the aim of the current study was to assess the efficacy of CUDC-907 (a dual inhibitor of histone deacetylase and phosphatidylinositide 3-kinase) in combination with 5-FU against CRC cells. MATERIALS AND METHODS: Cell viability was determined using AlamarBlue and colony formation assays...
January 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28138026/preclinical-evaluation-of-sequential-combination-of-oncolytic-adenovirus-delta-24-rgd-and-phosphatidylserine-targeting-antibody-in-pancreatic-ductal-adenocarcinoma
#7
Bingbing Dai, David Roife, Ya'an Kang, Joy Gumin, Mayrim V Rios Perez, Xinqun Li, Michael Pratt, Rolf A Brekken, Juan Fueyo-Margareto, Frederick F Lang, Jason B Fleming
Delta-24-RGD (DNX-2401) is a conditional replication-competent oncolytic virus engineered to preferentially replicate in and lyse tumor cells with abnormality of p16/RB/E2F pathway. In a phase 1 clinical trial, Delta-24-RGD has shown favorable safety profile and promising clinical efficacy in brain tumor, which prompted us to evaluate its anticancer activity in pancreatic ductal adenocarcinoma (PDAC), which also has high frequency of homozygous deletion and promoter methylation of CDKN2A encoding the p16 protein...
January 30, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28131994/ectopic-accumulation-of-linalool-confers-resistance-to-xanthomonas-citri-subsp-citri-in-transgenic-sweet-orange-plants
#8
Takehiko Shimada, Tomoko Endo, Ana Rodríguez, Hiroshi Fujii, Shingo Goto, Takakazu Matsuura, Yuko Hojo, Yoko Ikeda, Izumi C Mori, Takashi Fujikawa, Leandro Peña, Mitsuo Omura
In order to clarify whether high linalool content in citrus leaves alone induces strong field resistance to citrus canker caused by Xanthomonas citri subsp. citri (Xcc), and to assess whether this trait can be transferred to a citrus type highly sensitive to the bacterium, transgenic 'Hamlin' sweet orange (Citrus sinensis L. Osbeck) plants over-expressing a linalool synthase gene (CuSTS3-1) were generated. Transgenic lines (LIL) with the highest linalool content showed strong resistance to citrus canker when spray inoculated with the bacterium...
January 27, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28131777/synthesis-of-c5-tethered-indolyl-3-glyoxylamide-derivatives-as-tubulin-polymerization-inhibitors
#9
Sravanthi Devi Guggilapu, Guntuku Lalita, T Srinivasa Reddy, Santosh Kumar Prajapti, Atulya Nagarsenkar, Shymala Ramu, Uma Rani Brahma, Uppa Jaya Lakshmi, Ganga Modi Naidu Vegi, Suresh K Bhargava, Bathini Nagendra Babu
A series of C5-tethered Indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against DU145 (prostate), PC-3 (prostate), A549 (lung) and HCT-15 (colon) cancer cell lines by employing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among all the synthesized compounds, compound 7f displayed cytotoxicity of IC50 = 140 nM towards DU145 cancer cell line. The treatment of DU145 cells with 7f led to inhibition of cell migration ability...
January 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28130850/demethylating-and-anti-hepatocarcinogenic-potential-of-hesperidin-a-natural-polyphenol-of-citrus-juices
#10
Zahira Fernández-Bedmar, Jaouad Anter, Angeles Alonso-Moraga, Juana Martín de Las Mulas, Yolanda Millán-Ruiz, Silvia Guil-Luna
Hepatocellular carcinoma (HCC) is a neoplasia representing the fifth most common malignancy worldwide and the third cause of death from cancer. Diets with high content in fruits and vegetables are widely recommended for their health-promoting properties, among them, the protection against diabetes, cancer and cardiovascular diseases. Hesperidin is the most important phenol in the orange fruit with well-known health benefits. Diet components have been used as possible modulator agents of DNA methylation in cancer cells and epigenetic therapy against their harmful effects could be a potential tool in chemotherapy...
January 27, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28115093/%C3%AE%C2%BA-carrageenan-an-effective-drug-carrier-to-deliver-curcumin-in-cancer-cells-and-to-induce-apoptosis
#11
Malairaj Sathuvan, Ramar Thangam, Mani Gajendiran, Raju Vivek, Sengottuvelan Balasubramanian, Subramani Nagaraj, Palani Gunasekaran, Balaraman Madhan, Ramasamy Rengasamy
The current study is to develop a natural drug carrier with seaweed derived polymers namely κ-Carrageenan (κ-Car) for drug delivery applications. κ-Car is a natural polysaccharide which derived from edible red seaweeds, they are easily available, non-toxic, cost effective, biodegradable and biocompatible nature. Curcumin (Cur) is a yellow-orange polyphenol existing in turmeric, which is predominantly used as spice and food coloring agent. The ultimate use of polymeric composites, especially those composed of natural polymers, has become a very interesting approach in recent drug delivery applications, due to their non-toxicity and biological origin...
March 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28101129/a-traditional-poly-herbal-medicine-le-pana-guliya-induces-apoptosis-in-hepg2-and-hela-cells-but-not-in-cc1-cells-an-in-vitro-assessment
#12
Nekadage Don Amal Wageesha, Preethi Soysa, Keerthi Atthanayake, Muhammad Iqbal Choudhary, Mahinda Ekanayake
"Le Pana Guliya" (LPG) is a polyherbal formulation which is used to treat different types of cancers in traditional medicine. In this study we describe in vitro efficacy and mechanism of action of LPG on two cancer cell lines (HepG2 and HeLa) compared with a normal cell line CC1. The MTT, LDH assays and protein synthesis were used to study antiproliferative activity of LPG while NO synthesis and GSH content were assayed to determine the oxidative stress exerted by LPG. Rhodamine 123 staining, caspase 3 activity, DNA fragmentation and microscopic examination of cells stained with ethidium bromide/acridine orange were used to identify the apoptosis mechanisms associated with LPG...
2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/28096658/anticancer-and-anti-inflammatory-activities-of-girinimbine-isolated-from-murraya-koenigii
#13
Venoos Iman, Syam Mohan, Siddig Ibrahim Abdelwahab, Hamed Karimian, Noraziah Nordin, Mehran Fadaeinasab, Mohamad Ibrahim Noordin, Suzita Mohd Noor
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. Murraya koenigii is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a carbazole alkaloid isolated from M. koenigii, induced apoptosis and inhibited inflammation in vitro as well as in vivo. Induction of apoptosis in human colon cancer cells (HT-29) by girinimbine revealed decreased cell viability in HT-29, whereas there was no cytotoxic effect on normal colon cells...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28088570/achillea-millefolium-l-extract-mediated-green-synthesis-of-waste-peach-kernel-shell-supported-silver-nanoparticles-application-of-the-nanoparticles-for-catalytic-reduction-of-a-variety-of-dyes-in-water
#14
Bahar Khodadadi, Maryam Bordbar, Mahmoud Nasrollahzadeh
In this paper, silver nanoparticles (Ag NPs) are synthesized using Achillea millefolium L. extract as reducing and stabilizing agents and peach kernel shell as an environmentally benign support. FT-IR spectroscopy, UV-Vis spectroscopy, X-ray Diffraction (XRD), Field emission scanning electron microscopy (FESEM), Energy Dispersive X-ray Spectroscopy (EDS), Thermo gravimetric-differential thermal analysis (TG-DTA) and Transmission Electron Microscopy (TEM) were used to characterize peach kernel shell, Ag NPs, and Ag NPs/peach kernel shell...
January 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28088315/paris-saponin-induced-autophagy-promotes-breast-cancer-cell-apoptosis-via-the-akt-mtor-signaling-pathway
#15
Zhan-Zhi Xie, Man-Mei Li, Peng-Fei Deng, Sheng Wang, Lei Wang, Xue-Ping Lu, Liu-Bing Hu, Zui Chen, Hui-Yang Jie, Yi-Fei Wang, Xiao-Xiao Liu, Zhong Liu
Paris saponins possess anticancer, anti-inflammatory, and antiviral effects. However, the anticancer effect of Paris saponins has not been well elucidated and the mechanisms underlying the potential function of Paris saponins in cancer therapy are needed to be further identify. In this study, we report that saponin compounds isolated from Paris polyphylla exhibited antitumor activity against breast cancer cell lines, MCF-7 and MDA-MB-231. Paris saponin XA-2 induced apoptosis in both cell lines, as evidenced by the activation of caspases and cleavage of Poly (ADP-ribose) polymerase...
February 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28070070/quantitative-determination-of-iron-ions-based-on-a-resonance-raman-rr-probe-phenanthroline
#16
Liang Wang, Yi Zhang, Yeonju Park, Lei Chen, Young Mee Jung
In this paper, we demonstrate a new promising resonance Raman (RR)-based method for the determination of Fe(3+) concentrations in aqueous solutions. Iron ions were quantified at a low concentration range by employing hydroxylamine hydrochloride as the reductant, and phenanthroline as the complexing agent, thereby reducing Fe(3+) to Fe(2+). The addition of Fe(3+) to the detection reagent resulted in a rapid color change from colorless to orange-red, together with an obvious new RR band appearing at 1459 cm(-1)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28068602/synthesis-of-2-3-6-7-tetramethoxyphenanthren-9-amine-an-efficient-precursor-to-access-new-4-aza-2-3-dihydropyridophenanthrenes-as-apoptosis-inducing-agents
#17
Niggula Praveen Kumar, Pankaj Sharma, T Srinivasa Reddy, Shalini Nekkanti, Nagula Shankaraiah, Guntuku Lalita, S Sujanakumari, Suresh K Bhargava, V G M Naidu, Ahmed Kamal
A new route for the synthesis of novel 2,3,6,7-tetramethoxy phenanthrene amine precursor has been successfully accomplished. Subsequently, this amine precursor has been directly utilized for the synthesis of a new series of 4-aza-2,3-dihydropyridophenanthrene derivatives via a three component reaction with tetronic acid and substituted aldehydes. These compounds were evaluated for their cytotoxic potential against human lung (A549), prostate (PC-3 and DU145), breast (MDA-MB-231 and 4T1), gastric (HGC-27), colon (Caco-2) and cervical (HeLa) cancer cell lines...
January 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28066114/antigenotoxic-and-apoptotic-activities-of-essential-oil-of-atalantia-monophylla-correa
#18
Ramaraj Thirugnanasampandan, Gunasekar Ramya, Madusudhanan Gogulramnath
OBJECTIVE: To study antigenotoxic and apoptotic activities of hydrodistilled essential oil from the leaves of Atalantia monophylla Correa. MATERIALS AND METHODS: Antigenotoxic activity of essential oil was tested against hydrogen peroxide (100 μM)-induced deoxyribonucleic acid (DNA) damage in 3T3-L1 cells. Cervical cancer cell (HeLa) growth inhibitory effect of essential oil was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay. Annexin V-fluorescein isothiocyanate/propidium iodide (FITC/PI), Hoechst 33258, and acridine orange/ethidium bromide (AO/EtBr) staining techniques were used to identify apoptosis...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28040156/potential-of-a-new-strain-of-bacillus-amyloliquefaciens-buz-14-as-a-biocontrol-agent-of-postharvest-fruit-diseases
#19
H Calvo, P Marco, D Blanco, R Oria, M E Venturini
The biocontrol potential of the Bacillus amyloliquefaciens strain BUZ-14 was tested against the main postharvest diseases of orange, apple, grape and stone fruit. After characterizing the temperature and pH growth curves of strain BUZ-14, its in vitro antifungal activity was determined against Botrytis cinerea, Monilinia fructicola, M. laxa, Penicillium digitatum, P. expansum and P. italicum. Subsequently, in vivo activity was tested against these pathogens by treating fruit with cells, endospores and cell-free supernatants...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28038323/synthesis-and-biological-evaluation-of-curcumin-inspired-indole-analogues-as-tubulin-polymerization-inhibitors
#20
P V Sri Ramya, Srinivas Angapelly, Lalita Guntuku, Chander Singh Digwal, Bathini Nagendra Babu, V G M Naidu, Ahmed Kamal
In our endeavour towards the development of potent cytotoxic agents, a series of some new curcumin inspired indole analogues, in which indole and phenyl moieties are linked on either sides of 1,5-diaryl-1,4-pentadien-3-one system have been synthesized and characterized by spectral data. All the newly synthesized analogues were tested for their cytotoxic potential against a panel of eight cancer cell lines namely, lung (A549), breast (MDA-MB-231, BT549 and 4T1), prostate (PC-3, DU145), gastric (HGC-27) and cervical (HeLa)...
December 23, 2016: European Journal of Medicinal Chemistry
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