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https://www.readbyqxmd.com/read/29137449/differential-side-effects-profile-in-patients-with-mcrpc-treated-with-abiraterone-or-enzalutamide-a-meta-analysis-of-randomized-controlled-trials
#1
REVIEW
Raphael B Moreira, Marcio Debiasi, Edoardo Francini, Pier V Nuzzo, Guillermo De Velasco, Fernando C Maluf, Andre P Fay, Joaquim Bellmunt, Toni K Choueiri, Fabio A Schutz
Background: Abiraterone and enzalutamide are currently approved for mCRPC patients. Both drugs have distinct mechanisms of action and may have different toxicity profile. There are limited data comparing the side effects of abiraterone and enzalutamide. We performed a meta-analysis of randomized controlled trials (RCT) to better characterize the risk of adverse events associated with both drugs. Methods: We performed a literature search on MEDLINE for studies reporting abiraterone and enzalutamide side effects from January 1966 to July 31, 2015...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136603/prolonged-grief-reactions-after-old-age-spousal-loss-and-centrality-of-the-loss-in-post-loss-identity
#2
Lena Eckholdt, Lynn Watson, Maja O'Connor
BACKGROUND: The loss of a spouse is a major life event. Previous research found that centrality of the loss to one's identity using Centrality of Event Scale (CES) is related to complicated bereavement reactions, such as depression, posttraumatic stress symptoms (PTS), and prolonged grief symptoms (PGS). This study aims to examine loss-centrality in elderly bereaved people up to 4 years post loss, to determine the relation of loss-centrality to complicated bereavement reactions, such as PGS, depression, and PTS, and to identify early predictors of loss-centrality...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29136368/split-2-protein-ligation-generates-active-il-6-type-hyper-cytokines-from-inactive-precursors
#3
Jens Mark Moll, Melanie Wehmöller, Nils Christopher Frank, Lisa Homey, Paul Baran, Christoph Garbers, Larissa Lamertz, Jonathan H Axelrod, Eithan Galun, Henning D Mootz, Jürgen Scheller
Trans-signaling of the major pro- and anti-inflammatory cytokines Interleukin (IL)-6 and IL-11 has the unique feature to virtually activate all cells of the body and is critically involved in chronic inflammation and regeneration. Hyper-IL-6 and Hyper-IL-11 are single chain designer trans-signaling cytokines, in which the cytokine and soluble receptor units are trapped in one complex via a flexible peptide linker. Albeit, Hyper-cytokines are essential tools to study trans-signaling in vitro and in vivo, the superior potency of these designer cytokines are accompanied by undesirable stress responses...
November 14, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29132220/catheter-directed-thrombolysis-versus-standard-anticoagulation-for-acute-lower-extremity-deep-vein-thrombosis-a-meta-analysis-of-clinical-trials
#4
Yongming Lu, Linyi Chen, Jinhui Chen, Tao Tang
Standard anticoagulant treatment alone for acute lower extremity deep vein thrombosis (DVT) is ineffective in eliminating thrombus from the deep venous system, with many patients developing postthrombotic syndrome (PTS). Because catheter-directed thrombolysis (CDT) can dissolve the clot, reducing the development of PTS in iliofemoral or femoropopliteal DVT. This meta-analysis compares CDT plus anticoagulation versus standard anticoagulation for acute iliofemoral or femoropopliteal DVT. Ten trials were included in the meta-analysis...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29131737/the-use-of-yoga-by-physical-therapists-in-the-united-states
#5
Mary E Wims, Shayla M McIntyre, Ann York, Laura G Covill
How physical therapists (PTs) in the United States currently use yoga in their clinical practices is unknown. The purpose of this study was to determine how PTs in the United States view yoga as a physical therapy (PT) tool and how PTs use yoga therapeutically. The authors conducted a 24-item survey via electronic communications of the Geriatric, Orthopedic, Pediatric, and Women's Health Sections of the American Physical Therapy Association. Participants (n = 333) from 47 states and the District of Columbia replied...
November 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/29131296/complete-percutaneous-approach-versus-surgical-access-in-transfemoral-transcatheter-aortic-valve-implantation-results-from-a-multicenter-registry
#6
Janusz Kochman, Łukasz Kołtowski, Zenon Huczek, Bartosz Rymuza, Radosław Wilimski, Maciej Dąbrowski, Adam Witkowski, Marek Grygier, Anna Olasińska-Wiśniewska, Piotr Kubler, Krzysztof Reczuch, Radosław Parma, Andrzej Ochała, Dariusz Jagielak, Wacław Kochman, Eberhard Grube
BACKGROUND: Although the femoral approach is the most common route utilized in transcatheter aortic valve implantation (TAVI) it still carries a substantial risk of severe bleeding and vascular complications. The aim of our study was to compare the safety and efficacy of the complete percutaneous (CPC) approach with surgical cutdown and closure (SCC) in TAVI patients. METHODS: The study population comprised 683 patients with severe aortic stenosis who underwent transfemoral TAVI...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29131286/conscious-sedation-for-transcatheter-implantation-of-atrial-septal-occluders-with-the-2d-and-3d-transesophageal-echocardiography-guidance-the-feasibility-and-safety-study
#7
Piotr Lipiec, Dawid Miśkowiec, Jan Z Peruga, Michał Plewka, Ewa Szymczyk, Paulina Wejner-Mik, Karolina Kupczyńska, Jarosław D Kasprzak
BACKGROUND: General anesthesia may have negative impact on patients mortality and morbidity, as well as overall procedure costs in atrial septal occluders (ASO) implantation. AIM: We sought to evaluate the safety, efficacy and feasibility of conscious sedation for transcatheter implantation of ASO. METHODS: 122 patients (pts) referred for transcatheter implantation of ASO were included. Mean patients' age was 51±15 years, 43 patients were male (35%)...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29127495/size-and-heterologous-elements-predict-metastases-in-malignant-phyllodes-tumours-of-the-breast
#8
Valerie Cui Yun Koh, Aye Aye Thike, Nur Diyana Md Nasir, George Wai Cheong Yip, Boon Huat Bay, Puay Hoon Tan
Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms comprising 0.3-1.0% of all primary breast tumours. The majority of PTs are benign and generally well managed with surgery. However, malignant PTs, and occasionally borderline PTs, can behave in a clinically aggressive manner by metastasizing to distant organs. Although distant metastasis is rare, the prognosis of patients with metastasis is dismal as many are unresponsive to standard chemotherapy and the risk of death is high. In this study, we correlated clinicopathological parameters to survival outcomes in a cohort of patients diagnosed with malignant PTs in our institution...
November 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29127431/effect-of-cornea-preservation-time-on-success-of-descemet-stripping-automated-endothelial-keratoplasty-a-randomized-clinical-trial
#9
George O Rosenwasser, Loretta B Szczotka-Flynn, Allison R Ayala, Wendi Liang, Anthony J Aldave, Steven P Dunn, Tyrone McCall, Lisa C Navarro, Sudeep Pramanik, Kevin W Ross, R Doyle Stulting, Mark A Terry, Elmer Y Tu, David D Verdier, Craig Kollman, Robin L Gal, Roy W Beck, Jonathan H Lass
Importance: Demonstrating that success of Descemet stripping automated endothelial keratoplasty is similar across donor cornea preservation times (PTs) could increase the donor pool. Objective: To determine whether the 3-year rate of graft success using corneal donor tissue preserved 8 to 14 days is noninferior to that of donor tissue preserved 7 days or less. Design, Setting, and Participants: A multicenter, double-masked, randomized noninferiority clinical trial was conducted from April 16, 2012, to June 5, 2017, at 40 clinical sites (70 surgeons) in the United States, with donor corneas provided by 23 US eye banks...
November 10, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29126608/diagnostic-scales-for-the-post-thrombotic-syndrome
#10
Hilde Skuterud Wik, Tone R Enden, Waleed Ghanima, Marit Engeseth, Susan R Kahn, Per Morten Sandset
Post-thrombotic syndrome (PTS) is the most common long-term complication after deep vein thrombosis (DVT) developing in up to 70% of the patients. PTS is diagnosed on the basis of typical symptoms and signs of the lower limb with a previous DVT, but no objective diagnostic test exists. A number of diagnostic scales have been developed primarily for research purposes. An optimal diagnostic test for PTS should be reliable and easy to use, sensitive and specific, able to grade PTS severity, and to identify changes over time...
October 28, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29126446/detection-level-and-pattern-of-positive-lesions-using-psma-pet-ct-for-staging-prior-to-radiation-therapy
#11
Nina-Sophie Schmidt-Hegemann, Wolfgang Peter Fendler, Alexander Buchner, Christian Stief, Paul Rogowski, Maximilian Niyazi, Chukwuka Eze, Minglun Li, Peter Bartenstein, Claus Belka, Ute Ganswindt
BACKGROUND: To determine the potential role of (68)Ga-PSMA positron emission tomography/computed tomography (PET/CT) in radiotherapy (RT) planning for prostate cancer (PCa). METHODS: One hundred twenty-nine patients (pts) with (68)Ga-PSMA PET/CT were retrospectively analysed. Potentially influencing factors (androgen deprivation therapy, amount of (68)Ga-PSMA-HBED-CC, PSA doubling time ≤/> 10 months, PSA before PET/CT, T-/N-category and Gleason score) were evaluated by logistic regression analysis...
November 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29125559/endotoxin-induced-inflammation-suppresses-the-effect-of-melatonin-on-the-release-of-lh-from-the-ovine-pars-tuberalis-explants-ex-vivo-study
#12
Karolina Wojtulewicz, Dorota Tomaszewska-Zaremba, Andrzej Przemysław Herman
The secretion of the hormone melatonin reliably reflects environmental light conditions. Among numerous actions, in seasonal breeders, melatonin may regulate the secretion of the gonadotropins acting via its corresponding receptors occurring in the Pars Tuberalis (PT). However, it was previously found that the secretory activity of the pituitary may be dependent on the immune status of the animal. Therefore, this study was designed to determine the role of melatonin in the modulation of luteinizing hormone (LH) secretion from the PT explants collected from saline- and endotoxin-treated ewes in the follicular phase of the oestrous cycle...
November 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29122572/characterization-of-vessel-deformations-during-evar-a-preliminary-retrospective-analysis-to-improve-fidelity-of-endovascular-simulators
#13
Laura Cercenelli, Barbara Bortolani, Guido Tiberi, Chiara Mascoli, Ivan Corazza, Mauro Gargiulo, Emanuela Marcelli
OBJECTIVE: During endovascular aneurysm repair (EVAR), vessel deformations occur due to the insertion of tools and deployment of stent grafts in the arteries. We present a method for the characterization of vessel deformations during EVAR, and its application on patient datasets for a preliminary retrospective analysis that may be used to improve fidelity of endovascular simulators. DESIGN: The method provides the extraction of vessel profiles from intraoperative fluoroscopic images and the calculation of a tortuosity index in the 2D fluoroscopy view (τ2D) used to quantify the vessel deformations (δ%) during EVAR caused by the stiff guidewire insertion (δ%Stiff) and the stent graft deployment (δ%Graft), when compared with the undeformed vessel configuration (no device inserted)...
November 6, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29121989/determining-the-impact-of-a-new-physiotherapist-led-primary-care-model-for-back-pain-protocol-for-a-pilot-cluster-randomized-controlled-trial
#14
Jordan Miller, David Barber, Catherine Donnelly, Simon French, Michael Green, Jonathan Hill, Joy MacDermid, Jacquelyn Marsh, Kathleen Norman, Julie Richardson, Monica Taljaard, Timothy Wideman, Lynn Cooper, Colleen McPhee
BACKGROUND: Back pain is a leading contributor to disability, healthcare costs, and lost work. Family physicians are the most common first point of contact in the healthcare system for people with back pain, but physiotherapists (PTs) may be able to support the primary care team through evidence-based primary care. A cluster randomized trial is needed to determine the clinical, health system, and societal impact of a primary care model that integrates physiotherapists at the first visit for people with back pain...
November 9, 2017: Trials
https://www.readbyqxmd.com/read/29121581/clinicopathology-and-treatment-of-a-giant-malignant-phyllodes-tumor-of-the-breast-a-case-report-and-literature-review
#15
Wayne A Warner, Vandana Devika Sookdeo, Maurice Fortuné, Meenakshi Akhilesh, Chalapathi Rao Adidam Venkata, Wayne Mohammed, Cassandra Ramkissoon, Dave Harnanan, Lemuel Pran, Ravi Maharaj
INTRODUCTION: Phyllodes tumors (PTs) of the breast are extremely rare accounting for less than 1% of all breast tumors globally. Case records at the Trinidad and Tobago Cancer Registry show that only 0.003% of the reported breast cancer cases between 1995 and 2009 were PTs. PRESENTATION OF THE CASE: We report a 45-year-old woman who presented with swelling of the left breast. Ultrasound, mammogram and computed tomography imaging confirmed the presence of a mass in the right upper inner quadrant of the left breast...
October 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29119276/phase-ib-ii-study-of-gemcitabine-nab-paclitaxel-and-pembrolizumab-in-metastatic-pancreatic-adenocarcinoma
#16
Glen J Weiss, Lisa Blaydorn, Julia Beck, Kirsten Bornemann-Kolatzki, Howard Urnovitz, Ekkhard Schütz, Vivek Khemka
Background A single center phase Ib/II study of gemcitabine, nab-paclitaxel, and pembrolizumab (GNP) to evaluate the safety and efficacy in metastatic pancreatic adenocarcinoma (PDAC) was conducted (NCT02331251). Methods PDAC patients (pts) with measurable disease, biopsy proven metastasis, adequate laboratory tests, and KPS ≥ 70% received GNP until progression or toxicity. Safety monitoring, RECIST 1.1, and irRECIST assessments were conducted. Response imaging was performed prior to cycle 4, then every 3 months...
November 8, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29114851/biweekly-cisplatin-and-gemcitabine-in-patients-advanced-biliary-tract-cancer
#17
Daniel H Ahn, Josh Reardon, Chul W Ahn, Manojkumar Bupathi, Sameh Mikhail, Christina Sing-Ying Wu, Tanios Bekaii-Saab
Treatment with cisplatin with gemcitabine (CG) demonstrates a survival benefit in patients with advanced biliary tract cancer (ABTC). However, the weekly administration can add significant toxicities that may prohibit prolonged treatment. Based on previous studies, we implemented a modified biweekly regimen of GC in an attempt to optimize the prescribed regimen with an improved toxicity profile, added convenience to patients while maintaining efficacy. Patients with ABTC were treated with fixed dose rate (FDR) gemcitabine (1000mg/m(2) /min) and cisplatin 20mg/m(2) on days 1 and 15 of every 28-day cycle...
November 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29111323/the-role-of-the-ptsi-gene-on-ai-2-internalization-and-pathogenesis-of-avian-pathogenic-escherichia-coli
#18
Xiaoka Wu, Xiaolong Lv, Jinye Lu, Shengqing Yu, Yawei Jin, Jiangang Hu, Jiakun Zuo, Rongsheng Mi, Yan Huang, Kezong Qi, Zhaoguo Chen, Xiangan Han
The LuxS/AI-2 quorum sensing mechanism can regulate the physiological functions of avian pathogenic Escherichia coli (APEC) through internalization of the small molecule autoinducer-2 (AI-2). The ptsI gene encodes enzyme I, which participates in the phosphotransferase system (PTS) that regulates the virulence and AI-2 internalization of bacteria. The aim of the present study was to determine the effect of ptsI on AI-2 internalization and other pathogenesis process in APEC using a ptsI mutant of the APEC strain DE17 (serotype O2), namely DE17ΔptsI...
October 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29107937/avoidance-in-posttraumatic-stress-among-refugee-survivors-of-violent-conflict-and-atrocities-testing-trans-cultural-risk-processes-and-candidate-intervention-targets
#19
Kim Yuval, Amit Bernstein
BACKGROUND: A fast-growing population of refugees and survivors of violent conflict and atrocities are at risk for trauma-related mental health problems. Experimental clinical research key to the development of interventions tailored to this population is limited. AIMS: In an experimental psychopathology laboratory paradigm, we tested the expression and function of avoidance in posttraumatic stress (PTS) among a highly traumatized community sample of forcibly displaced refugees seeking asylum...
October 21, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29105470/-effect-of-medicated-catgut-embedding-at-changqiang-gv-1-on-mechanical-pain-threshold-and-p-38-mapk-expression-in-spinal-cord-tissue-in-anus-incisional-pain-rats
#20
Tao Shu, Shi-Ti Zhang, Feng Yan, Yu-Pei Ke, Jun Wang
OBJECTIVE: To observe the effect of medicated-catgut embedding at "Changqiang"(GV 1) on regional pain reaction and expression of p 38 MAPK in the dorsal horn of spinal cord in anus incisional pain rats, so as to explore its analgesic mechanism. METHODS: Forty male SD rats were randomly divided into control, model, GV 1-embedding and sham acupoint embedding groups (n=10 rats in each group). The anus incisional pain model was established by making a radial incision (about 10 mm length) at the left lithotomy position of the anus with a surgical knife, and the mechanical pain threshold (PT) was measured by using a Von Frey before and 4, 8, 12, 24 h after operation...
October 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
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