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Superoxide dismutase

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https://www.readbyqxmd.com/read/28534982/pre%C3%A2-treatment-with-chrysanthemum%C3%A2-indicum-linn%C3%A3-extract-protects-pyramidal-neurons-from-transient-cerebral-ischemia-via-increasing-antioxidants-in-the-gerbil-hippocampal-ca1-region
#1
In Hye Kim, Tae-Kyeong Lee, Jeong Hwi Cho, Jae-Chul Lee, Joon Ha Park, Ji Hyeon Ahn, Bich-Na Shin, Bai Hui Chen, Hyun-Jin Tae, Yang Hee Kim, Jong-Dai Kim, Young-Myeong Kim, Moo-Ho Won, Il Jun Kang
Chrysanthemum indicum Linné extract (CIL) is used in herbal medicine in East Asia. In the present study, gerbils were orally pre‑treated with CIL, and changes of antioxidant enzymes including superoxide dismutase (SOD) 1 and SOD2, catalase (CAT) and glutathione peroxidase (GPX) in the hippocampal CA1 region following 5 min of transient cerebral ischemia were investigated and the neuroprotective effect of CIL in the ischemic CA1 region was examined. SOD1, SOD2, CAT and GPX immunoreactivities were observed in the pyramidal cells of the CA1 region and their immunoreactivities were gradually decreased following ischemia‑reperfusion and barely detectable at 5 days post‑ischemia...
May 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534953/proteomic-analysis-of-differentially-expressed-proteins-in-kidneys-of-brain-dead-rabbits
#2
Ling Li, Ning Li, Chongxiang He, Wei Huang, Xiaoli Fan, Zibiao Zhong, Yanfeng Wang, Qifa Ye
A large number of previous clinical studies have reported a delayed graft function for brain dead donors, when compared with living relatives or cadaveric organ transplantations. However, there is no accurate method for the quality evaluation of kidneys from brain‑dead donors. In the present study, two‑dimensional gel electrophoresis and MALDI‑TOF MS‑based comparative proteomic analysis were conducted to profile the differentially‑expressed proteins between brain death and the control group renal tissues...
May 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534307/acanthus-ilicifolius-l-a-promising-candidate-for-phytostabilization-of-zinc
#3
A M Shackira, Jos T Puthur, E Nabeesa Salim
The potential of a halophyte species-Acanthus ilicifolius L.-to phytostabilize zinc (Zn) grown under hydroponics culture conditions was critically evaluated in this study. The propagules after treating with ZnSO4 (4 mM) were analysed for the bioaccumulation pattern, translocation rate of Zn to the shoot, effects of Zn accumulation on organic solutes and the antioxidant defence system. It was found that most of the Zn absorbed by the plant was retained in the root (47%) and only a small portion was transported to stem (12%) and leaves (11%)...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28533793/exogenous-supplementation-of-silicon-improved-the-recovery-of-hyperhydric-shoots-in-dianthus-caryophyllus-l-by-stabilizing-the-physiology-and-protein-expression
#4
Prabhakaran Soundararajan, Abinaya Manivannan, Yoon S Cho, Byoung R Jeong
Hyperhydricity is one of the major problems hindering in vitro propagation of Dianthus caryophyllus L. Silicon (Si) is a well-known beneficial element renowned for its stress amelioration properties in plants. This study has demonstrated the physiological and molecular mechanism behind the Si-mediated recovery from hyperhydricity in D. caryophyllus L. 'Green Beauty'. Four weeks old hyperhydric shoots obtained from temporary immersion system were cultured on the Murashige and Skoog medium supplemented with 0 (control), 1...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28533575/antihypertensive-effects-of-hydroalcoholic-extract-of-crataegus-azarolus-subspecies-aronia-fruit-in-rats-with-renovascular-hypertension-an-experimental-mechanistic-study
#5
Mohammad Reza Haydari, Mohammad Reza Panjeshahin, Elaheh Mashghoolozekr, Ali Akbar Nekooeian
BACKGROUND: Hawthorn species decreases blood pressure and relaxes precontracted vessels. This study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of Crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension. METHODS: Six groups of male Sprague-Dawley rats, each containing 6 to 8 rats, were studied. The groups comprised of one sham group and 5 renal artery-clipped groups. The sham group received vehicle (distilled water 0...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28533431/copper-zinc-superoxide-dismutase-is-activated-through-a-sulfenic-acid-intermediate-at-a-copper-ion-entry-site
#6
Morgan M Fetherolf, Stefanie D Boyd, Alexander B Taylor, Hee Jong Kim, James A Wohlschlegel, Ninian J Blackburn, P John Hart, Dennis R Winge, Duane D Winkler
Metallo-chaperones are a diverse family of trafficking molecules that provide metal ions to protein targets for use as cofactors. The copper chaperone for Sod1 (Ccs1) activates immature copper-zinc superoxide dismutase (Sod1) by delivering copper and facilitating the oxidation of the Sod1 intramolecular disulfide bond. Here, we present structural, spectroscopic, and cell-based data supporting a novel copper-induced mechanism for Sod1 activation. Ccs1 binding exposes an electropositive cavity and proposed "entry site" for copper ion delivery on immature Sod1...
May 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28533261/the-superoxide-dismutase-mimetic-tempol-does-not-alleviate-glucocorticoid-mediated-rarefaction-of-rat-skeletal-muscle-capillaries
#7
Erin R Mandel, Emily C Dunford, Ghoncheh Abdifarkosh, Patrick C Turnbull, Christopher G R Perry, Michael C Riddell, Tara L Haas
Sustained elevations in circulating glucocorticoids elicit reductions in skeletal muscle microvascular content, but little is known of the underlying mechanisms. We hypothesized that glucocorticoid-induced oxidative stress contributes to this phenomenon. In rats that were implanted with corticosterone (CORT) or control pellets, CORT caused a significant decrease in muscle glutathione levels and a corresponding increase in protein carbonylation, an irreversible oxidative modification of proteins. Decreased endothelial nitric oxide synthase and increased endothelin-1 mRNA levels were detected after 9 days of CORT, and blood flow to glycolytic muscles was diminished...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28533019/the-in-vitro-effect-of-nonylphenol-propranolol-and-diethylstilbestrol-on-quality-parameters-and-oxidative-stress-in-sterlet-acipenser-ruthenus-spermatozoa
#8
Olena Shaliutina, Ievgeniia Gazo, Anna Shaliutina-Kolešová, Ievgen Lebeda, Marek Rodina
The sturgeon is a highly endangered fish mostly due to over-fishing, habitat destruction, and water pollution. Nonylphenol (NP), propranolol (PN), and diethylstilbestrol (DES) are multifunctional xenobiotic compounds used in a variety of commercial and industrial products. The mechanism by which these xenobiotic compounds interfere with fish reproduction is not fully elucidated. This study assessed the effect of NP, PN, and DES on motility parameters, membrane integrity, and oxidative/antioxidant status in sterlet Acispenser ruthenus spermatozoa...
May 19, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28532855/long-term-influence-of-prenatal-high-sucrose-intake-on-learning-and-memory-of-aged-rat-offspring-with-oxidative-stress-and-disruptions-in-nmdars-wnt-signaling-in-hippocampus
#9
Axin He, Yingying Zhang, Lingjun Li, Xueqin Feng, Bin Wei, Di Zhu, Yanping Liu, Lei Wu, Lubo Zhang, Zhice Xu, Miao Sun
Maternal over-nutrition may increase risks of various diseases in the offspring. Our recent work demonstrated that prenatal high sucrose (HS) could impair spatial acquisitionin the adolescentoffspringrats. This study investigated whether prenatal HS has a long-term impact on cognitive capabilities in the aged offspring rats. The aged HS offspring showed impaired glucose tolerance, significantly increased fasting insulin and insulin resistance index, with unchanged plasma glucose. In the navigation test, the aged HS offspring exhibited longer escape latency and longer swimming path length to the platform...
May 19, 2017: Brain Research
https://www.readbyqxmd.com/read/28532685/nitroxide-4-hydroxy-2-2-6-6-tetramethylpiperidine-1-oxyl-tempol-inhibits-the-reductase-activity-of-protein-disulfide-isomerase-via-covalent-binding-to-the-cys400-residue-on-cxxc-redox-motif-at-the-a-active-site
#10
Gérsika Bitencourt Santos, Lucia Gonzalez-Perilli, Mauricio Mastrogiovanni, Adrián Aicardo, Cláudio Daniel Cerdeira, Andrés Trostchansky, Maísa Ribeiro Pereira Lima Brigagão
BACKGROUND AND AIM: Oxidative stress arising from inflammatory processes is a serious cause of cell and tissue damage. Tempol is an efficient antioxidant with superoxide dismutase-like activity. The purpose of this paper is to address the inhibition of protein disulfide isomerase (PDI), an essential redox chaperone whose active sites contain the Cys-Gly-His-Cys (CXXC) motif, by the nitroxide Tempol. RESULTS: In the presence of Tempol (5-120 μM), the reductase activity of PDI was reversibly affected both in vitro and in activated mice neutrophils, with an IC50 of 22...
May 19, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28532222/bromuconazole-induced-hepatotoxicity-is-accompanied-by-upregulation-of-pxr-cyp3a1-and-downregulation-of-car-cyp2b1-gene-expression
#11
Doaa H Abdelhady, Mohammed A El-Magd, Zizy I Elbialy, Ayman A Saleh
Despite widespread use of bromuconazole as a pesticide for food crops and fruits, limited studies have been done to evaluate its toxic effects. Here, we evaluated the hepatotoxic effect of bromuconazole using classical toxicological (biochemical analysis and histopathological examination) and gene-based molecular methods. Male rats were treated either orally or topically with bromuconazole at doses equal to no observed adverse effect level (NOAEL) and 1/10 LD50 for 90 days. Bromuconazole increased activities of liver enzymes (ALT, AST, ALP, and ACP), and levels of bilirubin...
May 23, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28532211/rotenone-induces-nephrotoxicity-in-rats-oxidative-damage-and-apoptosis
#12
Xiao-Wen Jiang, Lu Qiao, Xin-Xin Feng, Lin Liu, Qing-Wei Wei, Xue-Wei Wang, Wen-Hui Yu
Previous studies have examined rotenone toxicity on the human central nervous system, especially in the pathogenesis of Parkinson's disease, but few have investigated the effects of rotenone on the kidney. Here, rotenone-induced nephrotoxicity was evaluated by determining morphological, biochemical, oxidative stress-related, and apoptotic factor alterations in rat renal tissue. Morphological and biochemical analyses showed that rotenone administration to rats damaged renal tissue. Western blot results revealed that rotenone induced oxidative damage, causing overproduction of glutathione, malonaldehyde, and reactive oxygen species (ROS), and inhibiting superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity...
May 22, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28531990/safety-protocol-for-the-gold-nanoparticles-administration-in-rats
#13
Alexandre Pastoris Muller, Gabriela Kozuchovski Ferreira, Sabrina da Silva, Renata Tiscoski Nesi, Gustavo de Bem Silveira, Carolini Mendes, Ricardo A Pinho, Marcos Marques da Silva Paula, Paulo Cesar Lock Silveira
Gold nanoparticles (GNPs) have antioxidant and anti-inflammatory effects. However, toxicity is still a concern; therefore, it is critical to study both the therapeutic and toxic properties of GNPs. In this study, we evaluated the effects of the intraperitoneal administration of GNPs (20nm, at a concentration of 2.5mg/L for 21days) every 24 or 48h on oxidative stress, antioxidant status, and electron chain transport (ETC) in the brain. Liver histology and blood marker analyses were conducted to establish a time routine of GNP administration...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531964/non-electron-transfer-chain-mitochondrial-defects-differently-regulate-hif-1%C3%AE-degradation-and-transcription
#14
Antonina N Shvetsova, Daniela Mennerich, Juha M Kerätär, J Kalervo Hiltunen, Thomas Kietzmann
Mitochondria are the main consumers of molecular O2 in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α). While a number of mechanisms in the oxygen-dependent HIF-α regulation are quite well known, the view with respect to mitochondria is less clear. Several approaches using pharmacological or genetic tools targeting the mitochondrial electron transport chain (ETC) indicated that ROS, mainly formed at the Rieske cluster of complex III of the ETC, are drivers of HIF-1α activation...
May 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/28531762/high-dose-testosterone-enanthate-supplementation-boosts-oxidative-stress-but-exerts-little-effect-on-the-antioxidant-barrier-in-sedentary-adolescent-male-rat-liver
#15
Ewa Sadowska-Krepaa, Barbara Klapcinępa, Barbara Kłapcińska, Sławomir Jagsz, Anna Nowara, Izabela Szołtysek-Bołdys, Małgorzata Chalimoniuk, Józef Langfort, Stanisław J Chrapusta
BACKGROUND: Anabolic-androgenic steroids abuse is on the rise among adolescent boys and young men, mostly in those seeking a 'shortcut' to an improved body image. This approach is associated with the risk of severe adverse health effects, some of which involve the liver and are linked to hepatic oxidative stress. Testosterone and its esters is a cornerstone of most anabolic-androgenic steroid stacking protocols. METHODS: We assessed and compared several hepatotoxicity and liver oxidative stress indices, as well as the contents of some components of the hepatic antioxidant barrier between sedentary adolescent male rats given a 6-week course of weekly im testosterone enanthate (TE, 8 or 80mg/kgBW/week) or vehicle (sesame oil) injections...
March 11, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28531761/3%C3%AE-hydroxy-urs-12-en-28-oic-acid-confers-protection-against-znonps-induced-adversity-in-caenorhabditis-elegans
#16
Hema Negi, Shilpi Khare Saikia, Ranjana Kanaujia, Satish Jaiswal, Rakesh Pandey
Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) for overcoming the cytotoxic challenges of ZnONPs employing Ceanorhabditis elegans. The 24h LC50 of Zn-ONPs (<50nm TEM) was deduced as 4.75mgL(-1). UA (25μM) was observed to defend against this toxicity by attenuating Reactive Oxygen Species (ROS) resulting into better survival at 2mgL(-1) in a time dependent behavior...
May 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28531603/the-consumption-of-dietary-supplement-which-contains-plant-extracts-affects-superoxide-dismutase-activity-in-healthy-adults
#17
Maria Choleva, Eleftheria Alexandraki, Georgia Afxediou, Labrini Gabrihl, Chryssa Argyrou, Ioannis Malagaris, Elizabeth Fragopoulou
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28529531/the-protective-effect-of-lavender-essential-oil-and-its-main-component-linalool-against-the-cognitive-deficits-induced-by-d-galactose-and-aluminum-trichloride-in-mice
#18
Pan Xu, Kezhu Wang, Cong Lu, Liming Dong, Li Gao, Ming Yan, Silafu Aibai, Yanyan Yang, Xinmin Liu
Lavender essential oil (LO) is a traditional medicine used for the treatment of Alzheimer's disease (AD). It was extracted from Lavandula angustifolia Mill. This study was designed to investigate the effects of lavender essential oil (LO) and its active component, linalool (LI), against cognitive impairment induced by D-galactose (D-gal) and AlCl3 in mice and to explore the related mechanisms. Our results revealed that LO (100 mg/kg) or LI (100 mg/kg) significantly protected the cognitive impairments as assessed by the Morris water maze test and step-though test...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28529240/protective-effects-of-curcumin-on-manganese-induced-bv-2-microglial-cell-death
#19
Euteum Park, Hong Sung Chun
Curcumin, a bioactive component in tumeric, has been shown to exert antioxidant, anti-inflammatory, anticarcinogenic, hepatoprotective, and neuroprotective effects, but the effects of curcumin against manganese (Mn)-mediated neurotoxicity have not been studied. This study examined the protective effects of curcumin on Mn-induced cytotoxicity in BV-2 microglial cells. Curcumin (0.1-10 μM) dose-dependently prevented Mn (250 μM)-induced cell death. Mn-induced mitochondria-related apoptotic characteristics, such as caspase-3 and -9 activation, cytochrome c release, Bax increase, and Bcl-2 decrease, were significantly suppressed by curcumin...
May 20, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28528861/mechanism-of-melatonin-protection-against-copper-ascorbate-induced-oxidative-damage-in-vitro-through-isothermal-titration-calorimetry
#20
Arnab K Ghosh, Shamreen Naaz, Bharati Bhattacharjee, Nirajan Ghosal, Aindrila Chattopadhyay, Souvik Roy, Russel J Reiter, Debasish Bandyopadhyay
AIMS: Involvement of oxidative stress in cardiovascular diseases is well established. Melatonin's role as an antioxidant and free radical scavenger via its receptor dependent and receptor independent pathways is well known. The aim of this study is to identify and elaborate upon a third mechanism by which melatonin is able to abrogate oxidative stress. MAIN METHODS: Oxidative stress was induced in vitro, by copper (0.2mM)-ascorbate (1mM) in isolated goat heart mitochondria, cytosol and peroxisomes and they were co-incubated with graded doses of melatonin...
May 18, 2017: Life Sciences
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