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Varicella zoster virus

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https://www.readbyqxmd.com/read/28730326/infectious-diseases-causing-autonomic-dysfunction
#1
REVIEW
Francisco Javier Carod Artal
OBJECTIVES: To review infectious diseases that may cause autonomic dysfunction. METHODS: Review of published papers indexed in medline/embase. RESULTS: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Autonomic dysfunction is relatively common in HIV-infected patients and heart rate variability is reduced even in early stages of infection...
July 20, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28728870/outpatient-dermatology-consultation-impacts-the-diagnosis-and-management-of-pediatric-oncology-patients-a-retrospective-study
#2
Hannah Song, Sarah N Robinson, Jennifer T Huang
BACKGROUND: The impact of dermatology consultation on the care of children with oncologic conditions is unknown. OBJECTIVE: To review outpatient dermatology visits and the resulting impact on diagnosis and management of pediatric oncology patients. METHOD: Retrospective review of pediatric oncology patients with outpatient dermatology visits at a tertiary care center from 2008 to 2015. RESULTS: The most common dermatologic diagnoses in 516 patients were skin infections (21...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28725563/atypical-hemolytic-uremic-syndrome-triggered-by-varicella-infection
#3
Pauline Condom, Jean-Michel Mansuy, Stéphane Decramer, Jacques Izopet, Catherine Mengelle
Varicella Zoster Virus (VZV) is a well-known virus that belongs to the Herpesviridae family which induces a self-limited disease except in specific cases in particular among stem cell transplant patients. This virus is not known however to trigger atypical Hemolytic Uremic Syndrome (aHUS). Here we report the case of a six-year-old boy who was hospitalized with fever and abdominal pains associated to pruritic and vesicular rash, thrombocytopenia and acute renal failure. He was diagnosed with aHUS precipitated by varicella virus...
2017: IDCases
https://www.readbyqxmd.com/read/28705842/facial-palsy-and-atrial-fibrillation-a-special-case-of-ramsay-hunt-syndrome
#4
Fares Ayoub, Dhruv Mahtta, Roland-Austin Federico, Michael Kaufmann
Ramsay Hunt syndrome (herpes zoster oticus) is a rare complication of latent Varicella Zoster virus infection. It can be complicated by permanent hearing loss, loss of taste and postherpetic neuralgia. Although Ramsay Hunt syndrome most prominently involves the facial nerve, a number of other cranial nerves can be involved such as the vestibulocochlear, glossopharyngeal and the vagus nerve. We report on a case of Ramsay Hunt syndrome with cranial polyneuritis complicated by atrial fibrillation. Vagal involvement as evidenced by physical examination and MRI findings was present in our patient...
July 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28705150/economic-burden-of-varicella-in-children-1-12%C3%A2-years-of-age-in-hungary-2011-2015
#5
Z Meszner, Z Molnar, E Rampakakis, H K Yang, B J Kuter, Lara J Wolfson
BACKGROUND: Although live-attenuated varicella-zoster virus (VZV) vaccines have been proven to be safe and effective in preventing varicella and real-word evidence shows routine childhood immunization programs are effective in dramatically reducing varicella associated morbidity and mortality, varicella vaccine is not included in the National Immunization Program (NIP) in Hungary. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Hungary...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28698046/simian-varicella-virus-causes-robust-transcriptional-changes-in-t-cells-that-support-viral-replication
#6
Nicole Arnold, Ilhem Messaoudi
Varicella zoster virus (VZV) causes varicella (chickenpox) during acute infection. Several studies have shown that T cells are early and preferential targets of VZV infection that play a critical role in disseminating VZV in to the skin and ganglia. However, the transcriptional changes that occur in VZV-infected T cells remain unclear due to limited access to clinical samples and robust translational animal models. In this study, we used a nonhuman primate model of VZV infection where rhesus macaques are infected with the closely related Simian Varicella Virus (SVV) to provide novel insights into VZV-T cell interactions...
July 8, 2017: Virus Research
https://www.readbyqxmd.com/read/28684923/bilateral-herpes-zoster-in-a-patient-with-end-stage-kidney-disease
#7
Tetsu Akimoto, Shigeaki Muto, Daisuke Nagata
Herpes zoster (HZ) is caused by the reactivation of a latent varicella-zoster virus (VZV) infection within the cranial or dorsal root ganglia. The cutaneous lesions of HZ are typically limited to a single dermatome, while non-contiguous HZ involving two or more dermatomes is a very rare clinical entity. In this report, we describe a case of HZ involving the left and right side of the abdomen corresponding to the T11 dermatome in a 63-year-old man on chronic peritoneal dialysis. The characteristic cutaneous manifestation encouraged us to ascribe the disease to HZ duplex bilateralis, and the patient was given a single dose of oral valacyclovir and achieved a favorable outcome...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28683106/cytomegalovirus-infection-in-hiv-infected-and-uninfected-individuals-is-characterized-by-circulating-regulatory-t-cells-of-unconstrained-antigenic-specificity
#8
Adriana Tovar-Salazar, Adriana Weinberg
Cytomegalovirus (CMV) infection is associated with immune-suppression in immune-compromised hosts and old adults. We previously showed that ex vivo CMV restimulation of peripheral blood mononuclear cells (PBMC) of CMV-seropositive volunteers expanded CD4+CD27-CD28- regulatory T cells (Tregs). Here we evaluate the phenotype and function of circulating CD4+CD27-CD28- T cells of CMV-seropositive adults. Compared with CMV-seronegative, CMV-seropositive adults had 10-fold higher CD4+CD27-CD28-% T cells in PBMC. Circulating CD4+CD27-CD28- T cells from both CMV-seropositive and seronegative donors expressed higher levels of TGFβ, granzyme B, CD39, CD147 and IL-35, and lower levels of CD127, compared with their parent circulating CD4+ T cells...
2017: PloS One
https://www.readbyqxmd.com/read/28682067/expanding-the-antiviral-spectrum-of-3-fluoro-2-phosphonomethoxy-propyl-acyclic-nucleoside-phosphonates-diamyl-aspartate-amidate-prodrugs
#9
Min Luo, Elisabetta Groaz, Graciela Andrei, Robert Snoeck, Raj Kalkeri, Roger G Ptak, Tracy Hartman, Robert W Buckheit, Dominique Schols, Steven De Jonghe, Piet Herdewijn
Acyclic nucleosides containing a 3-fluoro-2-(phosphonomethoxy)propyl (FPMP) side chain are known to be moderately potent antihuman immunodeficiency virus (HIV) agents, while being completely devoid of antiviral activity against a wide range of DNA viruses. The derivatization of the phosphonic acid functionality of FPMPs with a diamyl aspartate phenoxyamidate group led to a novel generation of compounds that not only demonstrate drastically improved antiretroviral potency but also are characterized by an expanded spectrum of activity that also covers hepatitis B and herpes viruses...
July 6, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28681577/tuberculous-meningitis-mimicking-varicella-zoster-meningitis
#10
Sun In Hong, Taeeun Kim, Jiwon Jung, Se Yoon Park, Yong Pil Chong, Sang Oh Lee, Sang Ho Choi, Yang Soo Kim, Jun Hee Woo, Sang Ahm Lee, Sung Han Kim
BACKGROUND: Varicella-zoster virus (VZV) is one of the most common etiologies of aseptic meningitis. The severest manifestation of VZV meningitis is occasionally confused with tuberculous meningitis (TBM). Thus, we investigated the clinical manifestations of VZV meningitis as compared with those of TBM. MATERIALS AND METHODS: All adult patients who were diagnosed with VZV meningitis or TBM were enrolled at a tertiary hospital in Seoul, South Korea, during an 8-year period...
June 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28670753/human-varicella-zoster-virus-is-not-present-in-the-semen-of-a-man-affected-by-chickenpox-during-the-in-vitro-fertilisation-of-his-wife
#11
D Y L Chan, K K W Lam, E Y L Lau, W S B Yeung, E H Y Ng
Human varicella zoster virus (VZV) is a member of the herpes virus family and affects humans only. Information about the presence of the virus in the semen samples of men affected by chickenpox is rather limited in the literature. Here, we reported a husband was affected by VZV during in vitro fertilisation treatment of his wife treated in our centre. The semen sample was checked for the presence of VZV by the PCR technique. The PCR result found no detectable viral DNA in the semen sample. The semen sample was then used for conventional IVF insemination and subsequently a healthy baby boy was born...
July 3, 2017: Andrologia
https://www.readbyqxmd.com/read/28669106/oral-shedding-of-human-herpesviruses-in-renal-transplant-recipients
#12
Dmitry José de Santana Sarmento, Tânia Regina Tozetto-Mendoza, Laura Masami Sumita, Ligia Camara Pierroti, Débora Pallos, Rubens Caliento, Michelle Palmieri, Victor Adriano de Oliveira Martins, Marina Gallottini, Claudio Sergio Pannuti, Paulo Henrique Braz-Silva
OBJECTIVE: To describe the shedding profile of human herpesviruses in the saliva of renal transplant recipients. METHODS: This is a prospective case-control study of 50 renal transplant recipients and control group of 50 individuals (non-transplanted and immunocompetent). Mouthwash samples were collected via oral rinse and then submitted to screening for the presence of eight types of herpesviruses by using multiplex PCR. Fisher's exact, chi-square, and Student t tests were used for statistical analysis, and the significance level was set at 5%...
July 1, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28668556/1-2-3-4-6-penta-o-galloyl-%C3%A3-d-glucose-a-bioactive-compound-in-elaeocarpus-sylvestris-extract-inhibits-varicella-zoster-virus-replication
#13
Sohee Bae, Sun Yeou Kim, Moon Ho Do, Chan Hee Lee, Yoon-Jae Song
The aim of this study was to establish the effect of a 70% ethanol extract of Elaeocarpus sylvestris (ESE) on varicella-zoster virus (VZV) replication and identify the specific bioactive component(s) underlying its activity. ESE induced a significant reduction in replication of the clinical strain of VZV. Activity-guided fractionation indicated that the ethyl acetate (EtOAc) fraction of ESE contains the active compound(s) inhibiting VZV replication. High-Performance Liquid Chromatography coupled to Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry (HPLC-Q-TOF-MS/MS) analysis of the EtOAc fraction of ESE facilitated the identification of 13 chemical components...
June 29, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28666730/risk-factors-for-secondary-glaucoma-in-herpetic-anterior-uveitis
#14
Lisette Hoeksema, Nomdo M Jansonius, Leonoor I Los
PURPOSE: To determine the incidence of elevated intraocular pressure (IOP) and secondary glaucoma in herpetic anterior uveitis (AU), due to either herpes simplex or varicella zoster virus, by using the Standardization of Uveitis Nomenclature (SUN) criteria, and to identify risk factors for the development of glaucoma. DESIGN: Retrospective, observational cohort study. METHODS: Patients with herpetic AU presenting themselves between 2001 and 2013 at the ophthalmology department of the University Medical Center Groningen were included...
June 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28662876/herpes-zoster-involving-the-second-division-of%C3%A2-the-trigeminal-nerve-case-report-and-literature%C3%A2-review
#15
Rebecca Paquin, Lisiane F Susin, Garrett Welch, Jonathan B Barnes, Mark R Stevens, Franklin R Tay
Herpes zoster along the maxillary division of the trigeminal nerve is a rare condition that is caused by reactivation of the varicella zoster virus that resides within the trigeminal ganglion after the primary infection of chickenpox. The disease may be manifested as a toothache during its prodromal stage. The active stage of the disease is characterized by the appearance of a vesicular rash. Postherpetic neuralgia is a common complication of herpes zoster after resolution of the facial and intraoral symptoms...
June 26, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28662875/the-role-of-varicella-zoster-virus-in-the-development-of-periapical-pathoses-and-root-resorption-a-systematic-review
#16
REVIEW
Aleksandar Jakovljevic, Jovana Kuzmanovic Pficer, Irina F Dragan, Aleksandra Knezevic, Maja Miletic, Katarina Beljic-Ivanovic, Jelena Milasin, Miroslav Andric
INTRODUCTION: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. METHODS: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus...
June 26, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28657969/varicella-related-primary-healthcare-visits-hospitalizations-and-mortality-in-norway-2008-2014
#17
Grazina Mirinaviciute, Erle Kristensen, Britt Nakstad, Elmira Flem
BACKGROUND: Norway does not currently implement universal varicella vaccination in childhood. We aimed to characterize healthcare burden of varicella in Norway in the pre-vaccine era. METHODS: We linked individual patient data from different national registries to examine varicella vaccinations and varicella-coded primary care consultations, hospitalizations, outpatient hospital visits, deaths, and viral infections of central nervous system (CNS) in the whole population of Norway during 2008-2014...
June 27, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28652792/severe-atypical-herpes-zoster-as-an-initial-symptom-of-fatal-myelodysplastic-syndrome-with-refractory-anemia-and-blast-excess-raeb-ii
#18
Uwe Wollina, Gesina Hansel, Anja Baunacke, Georgi Tchernev
Herpes zoster is a common disease caused due to varicella zoster virus (VZV) infection with increasing incidence by age. If the patient has a severe, extended, or treatment-recalcitrant course of herpes zoster, this must be a red flag to search for underlying pathologies. Here, we report about a 64-year-old male patient with diabetes, who came to our emergency department because of general malaise, fever, chills, and a pronounced nuchal and facial swelling on the left side. Based on herpetiform-grouped vesicles and yellowish crusts, an impetiginized facial herpes zoster was diagnosed, and combined antiviral and antibiotic treatment was initiated...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28649633/latent-virus-reactivation-in-astronauts-on-the-international-space-station
#19
Satish K Mehta, Mark L Laudenslager, Raymond P Stowe, Brian E Crucian, Alan H Feiveson, Clarence F Sams, Duane L Pierson
Reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female) before, during, and after long-duration (up to 180 days) spaceflight onboard the international space station . Twenty age-matched and sex-matched healthy ground-based subjects were included as a control group. Blood, urine, and saliva samples were collected before, during, and after spaceflight. Saliva was analyzed for Epstein-Barr virus, varicella-zoster virus, and herpes simplex virus type 1. Urine was analyzed for cytomegalovirus...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28647346/sting-is-involved-in-antiviral-immune-response-against-vzv-infection-via-the-induction-of-type-i-and-iii-ifn-pathways
#20
Ji-Ae Kim, Seul-Ki Park, Seong-Wook Seo, Chan-Hee Lee, Ok Sarah Shin
Varicella Zoster Virus (VZV) is a human-restricted α-herpesvirus that exhibits tropism for the skin. The VZV host receptors and downstream signaling pathways responsible for the antiviral innate immune response in the skin are not completely understood. Here, we show that stimulator of interferon genes (STING) mediates an important host defense against VZV infection in dermal cells including human dermal fibroblasts (HDFs) and HaCaT keratinocytes. Inhibition of STING using small interfering RNA (siRNA) or short hairpin RNA (shRNA)-mediated gene disruption resulted in enhanced viral replication but diminished IRF3 phosphorylation and induction of IFNs and pro-inflammatory cytokines...
June 21, 2017: Journal of Investigative Dermatology
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