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https://www.readbyqxmd.com/read/27102185/smokehaz-systematic-reviews-and-meta-analyses-of-the-effects-of-smoking-on-respiratory-health
#1
Leah Jayes, Patricia L Haslam, Christina G Gratziou, Pippa Powell, John Britton, Constantine Vardavas, Carlos Jimenez-Ruiz, Jo Leonardi-Bee
BACKGROUND: Smoking tobacco increases the risk of respiratory disease in adults and children, but communicating the magnitude of these effects in a scientific manner that is accessible and usable by the public and policymakers presents a challenge. We have therefore summarized scientific data on the impact of smoking on respiratory diseases to provide the content for a unique resource, SmokeHaz. METHODS: We conducted systematic reviews and meta-analyses of longitudinal studies (published to 2013) identified from electronic databases, gray literature, and experts...
July 2016: Chest
https://www.readbyqxmd.com/read/26962806/pre-existing-pulmonary-diseases-and-survival-in-patients-with-stage-dependent-lung-adenocarcinoma-a-strobe-compliant-article
#2
Zhi-Hong Jian, Jing-Yang Huang, Oswald Ndi Nfor, Kai-Ming Jhang, Wen-Yuan Ku, Chien-Chang Ho, Chia-Chi Lung, Hui-Hsien Pan, Yu-Chiu Liang, Ming-Fang Wu, Yung-Po Liaw
Asthma, chronic obstructive pulmonary disease (COPD), and pulmonary tuberculosis (TB) are common lung diseases associated with lung cancer mortality. This study evaluated sex disparities in pre-existing pulmonary diseases and stage-dependent lung adenocarcinoma survival.Patients newly diagnosed with lung adenocarcinoma between 2003 and 2008 were identified using the National Health Insurance Research Database and Cancer Registry. Cases with lung adenocarcinoma were followed until the end of 2010. Survival curves were estimated by the Kaplan-Meier method...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26846830/the-emerging-role-of-myeloid-derived-suppressor-cells-in-lung-diseases
#3
Saeed Kolahian, Hasan Halit Öz, Benyuan Zhou, Christoph M Griessinger, Nikolaus Rieber, Dominik Hartl
Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterised by their potential to control T-cell responses and to dampen inflammation. While the role of MDSCs in cancer has been studied in depth, our understanding of their relevance for infectious and inflammatory disease conditions has just begun to evolve. Recent studies highlight an emerging and complex role for MDSCs in pulmonary diseases. In this review, we discuss the potential contribution of MDSCs as biomarkers and therapeutic targets in lung diseases, particularly lung cancer, tuberculosis, chronic obstructive pulmonary disease, asthma and cystic fibrosis...
March 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/26767408/dyspnoea-as-a-predictor-of-cause-specific-heart-lung-disease-mortality-in-bangladesh-a-prospective-cohort-study
#4
Gene R Pesola, Maria Argos, Vernon M Chinchilli, Yu Chen, Faruque Parvez, Tariqul Islam, Alauddin Ahmed, Rabiul Hasan, Muhammad Rakibuz-Zaman, Habibul Ahsan
BACKGROUND: The spectrum of mortality outcomes by cause in populations with/without dyspnoea has not been determined. The study aimed to evaluate whether dyspnoea, a symptom, predicts cause-specific mortality differences between groups. The hypothesis was that diseases that result in chronic dyspnoea, those originating from the heart and lungs, would preferentially result in heart and lung disease mortality in those with baseline dyspnoea (relative to no dyspnoea) when followed over time...
July 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/26756025/waterpipe-tobacco-smoking-a-new-smoking-epidemic-among-the-young
#5
Eric K Soule, Thokozeni Lipato, Thomas Eissenberg
Waterpipe (hookah, narghile) tobacco smoking (WTS) is becoming prevalent worldwide and is one of the most popular forms of tobacco use among youth. WTS prevalence has increased dramatically among youth in the United States within the past decade. Misperceived as less harmful than cigarette smoking, WTS is associated with many of the same chronic health effects such as lung cancer, chronic obstructive pulmonary disease, cardiovascular disease, bronchitis, and asthma. Much of this risk is due to the fact that a single WTS session exposes users to large volumes of smoke that contain toxic chemicals such as carbon monoxide, cancer-causing polycyclic aromatic hydrocarbons, and volatile aldehydes...
December 1, 2015: Current Pulmonology Reports
https://www.readbyqxmd.com/read/26526071/the-effects-of-pulmonary-diseases-on-histologic-types-of-lung-cancer-in-both-sexes-a-population-based-study-in-taiwan
#6
Jing-Yang Huang, Zhi-Hong Jian, Oswald Ndi Nfor, Wen-Yuan Ku, Pei-Chieh Ko, Chia-Chi Lung, Chien-Chang Ho, Hui-Hsien Pan, Chieh-Ying Huang, Yu-Chiu Liang, Yung-Po Liaw
BACKGROUND: The associations between pulmonary diseases (asthma, chronic obstructive pulmonary disease [COPD], and tuberculosis [TB]) and subsequent lung cancer risk have been reported, but few studies have investigated the association with different histologic types of lung cancer. METHODS: Patients newly diagnosed with lung cancer from 2004 to 2008 were identified from the National Health Insurance Research Database in Taiwan. Histologic types of lung cancer were further confirmed using the Taiwan Cancer Registry Database...
2015: BMC Cancer
https://www.readbyqxmd.com/read/26508848/effect-of-tiotropium-on-lung-function-decline-in-early-stage-of-chronic-obstructive-pulmonary-disease-patients-propensity-score-matched-analysis-of-real-world-data
#7
Ha Youn Lee, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Deog Kyeom Kim, Sang-Min Lee, Ho Il Yoon, Jae-Joon Yim, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo
BACKGROUND: Tiotropium failed to slow the annual rate of forced expiratory volume in 1 second (FEV1) decline in chronic obstructive pulmonary disease (COPD) patients with <70% predicted FEV1. However, the rate of FEV1 decline is known to be faster at early stages, which suggests that the effects of tiotropium may be more prominent in early-stage of COPD patients. The aim of this study was to test the hypothesis that tiotropium modifies the rate of FEV1 decline in COPD patients with an FEV1≥70%...
2015: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/26196516/the-impact-of-coexisting-asthma-chronic-obstructive-pulmonary-disease-and-tuberculosis-on-survival-in-patients-with-lung-squamous-cell-carcinoma
#8
Jing-Yang Huang, Zhi-Hong Jian, Oswald Ndi Nfor, Kai-Ming Jhang, Wen-Yuan Ku, Pei-Chieh Ko, Shiou-Rung Jan, Chien-Chang Ho, Chia-Chi Lung, Hui-Hsien Pan, Yu-Chiu Liang, Yung-Po Liaw
BACKGROUND: Pulmonary diseases [asthma, chronic obstructive pulmonary disease (COPD), and tuberculosis (TB)] are associated with lung cancer mortality. However, the relationship between coexisting pulmonary diseases and survival in patients with lung squamous cell carcinoma (SqCC) has not been well defined. METHODS: Patients newly diagnosed with SqCC between 2003 and 2008 were identified by linking the National Health Insurance Research Database and Taiwan Cancer Registry Database...
2015: PloS One
https://www.readbyqxmd.com/read/25992446/sirna-based-therapies-for-pulmonary-diseases
#9
REVIEW
Uday Koli, R Akhil Krishnan, Prasad Pofali, Ratnesh Jain, Prajakta Dandekar
Various delivery strategies, involving siRNA as a therapeutic tool for gene silencing, have been highlighted through several investigations all over the world. One such medical target, where the siRNA-based therapies have been immensely explored and have met with considerable success, is the area of pulmonary disorders. Lung diseases have presented themselves as attractive targets for studying siRNA-mediated cures due to their widespread persistence and lethality. Another interesting feature in this case is that the lung is accessible to therapeutic agents via multiple administration routes including the nasal, oral and intravenous routes...
September 2014: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/25882805/statement-on-smoking-cessation-in-copd-and-other-pulmonary-diseases-and-in-smokers-with-comorbidities-who-find-it-difficult-to-quit
#10
REVIEW
Carlos A Jiménez-Ruiz, Stefan Andreas, Keir E Lewis, Philip Tonnesen, C P van Schayck, Peter Hajek, Serena Tonstad, Bertrand Dautzenberg, Monica Fletcher, Sarah Masefield, Pippa Powell, Thomas Hering, Stefano Nardini, Thomy Tonia, Christina Gratziou
Chronic obstructive pulmonary disease (COPD), lung cancer, asthma and pulmonary tuberculosis are common pulmonary diseases that are caused or worsened by tobacco smoking. Growing observational evidence suggests that symptoms and prognosis of these conditions improve upon smoking cessation. Despite increasing numbers of (small) randomised controlled trials suggesting intensive smoking cessation treatments work in people with pulmonary diseases many patients are not given specific advice on the benefits or referred for intensive cessation treatments and, therefore, continue smoking...
July 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/25634179/impact-of-coexisting-pulmonary-diseases-on-survival-of-patients-with-lung-adenocarcinoma-a-strobe-compliant-article
#11
Zhi-Hong Jian, Jing-Yang Huang, Pei-Chieh Ko, Shiou-Rung Jan, Oswald Ndi Nfor, Chia-Chi Lung, Wen-Yuan Ku, Chien-Chang Ho, Hui-Hsien Pan, Yung-Po Liaw
Asthma, chronic obstructive pulmonary disease (COPD), and pulmonary tuberculosis (TB) are common pulmonary diseases associated with lung cancer. Besides, smoking is more prevalent in Taiwanese men. This study evaluated gender disparities in coexisting pulmonary diseases on survival of patients with lung adenocarcinoma. Patients newly diagnosed with lung cancer between 2003 and 2008 were identified from Taiwan National Health Insurance Research Database. Cases with lung adenocarcinoma were further confirmed using the Cancer Registry Database and followed up until the end of 2010...
January 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25530134/flow-cytometry-applications-in-the-study-of-immunological-lung-disorders
#12
REVIEW
Esmaeil Mortaz, Hoda Gudarzi, Payam Tabarsi, Ian M Adcock, Mohamad Reza Masjedi, Hamid Reza Jamaati, Johan Garssen, Ali Akbar Velayati, Frank A Redegeld
The use of flow cytometry in the clinical laboratory has grown substantially in the past decade. Flow cytometric analysis provides a rapid qualitative and quantitative description of multiple characteristics of individual cells. For example, it is possible to detect the cell size and granularity, aspects of DNA and RNA content and the presence of cell surface and nuclear markers which are used to characterize the phenotype of single cells. Flow cytometry has been used for the immunophenotyping of a variety of specimens including whole blood, bone marrow, serous cavity fluids, (cerebrospinal fluid) CSF, urine and all types of body fluids...
February 2015: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/25501048/the-coexistence-of-common-pulmonary-diseases-on-the-histologic-type-of-lung-cancer-in-both-genders-in-taiwan-a-strobe-compliant-article
#13
Zhi-Hong Jian, Chia-Chi Lung, Jing-Yang Huang, Pei-Chieh Ko, Shiou-Rung Jan, Oswald Ndi Nfor, Wen-Yuan Ku, Chien-Chang Ho, Hui-Hsien Pan, Yung-Po Liaw
Effects of pulmonary diseases [asthma, chronic obstructive pulmonary disease (COPD), and lung tuberculosis (TB)] on subsequent lung cancer development have been reported. However, whether patients with coexisting pulmonary diseases are at greater risk of developing various histologic types of lung cancer remains elusive. Patients newly diagnosed with lung cancer between 2004 and 2008 were identified from National Health Insurance Research Database (Taiwan). The histologic types of lung cancer were further confirmed using Taiwan Cancer Registry Database...
December 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25241555/-evidences-related-to-pulmonary-rehabilitation-in-the-respiratory-pathology
#14
REVIEW
Alina Croitoru, Miron Alexandru Bogdan
Pulmonary rehabilitation represents a modern therapeutic approach of respiratory diseases, with a multidisciplinary character, including: physical training, therapeutic education, psychosocial counseling, and nutritional approach. Pulmonary rehabilitation addresses to any patient suffering from pulmonary pathology whose quality of life is affected by the respiratory symptoms, regardless of the degree of functional impairment. This article is an analysis of evidences from the medical literature on outcomes of rehabilitation programs conducted in various lung diseases...
April 2014: Pneumologia: Revista Societății Române de Pneumologie
https://www.readbyqxmd.com/read/24678708/nanocarriers-for-respiratory-diseases-treatment-recent-advances-and-current-challenges
#15
REVIEW
Adriana Trapani, Sante Di Gioia, Stefano Castellani, Annalucia Carbone, Gennara Cavallaro, Giuseppe Trapani, Massimo Conese
Pulmonary delivery of locally-acting drugs encapsulated in nanocarriers provides several advantages for the treatment of respiratory diseases such as asthma, chronic obstructive pulmonary diseases, cystic fibrosis, tuberculosis and lung cancer. These advantages include, among others, sustained drug delivery to the lungs, reduced therapeutic dose and improved patient compliance. The aim of this review is to give an updated overview on recent advances recorded in the last few years in this field as well as on the major challenges still existing and that remain to be overcome before any clinical application...
2014: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/24673697/lung-disease-in-a-global-context-a-call-for-public-health-action
#16
Neil W Schluger, Ram Koppaka
As described in a recently released report of the Forum of International Respiratory Societies, four of the leading causes of death in the world are chronic obstructive pulmonary disease, acute respiratory tract infections, lung cancer, and tuberculosis. A fifth, asthma, causes enormous global morbidity. Not enough progress has been made in introducing new therapies and reducing disease burden for these illnesses in the last few decades, despite generous investments and some notable progress in biomedical research...
March 2014: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/24673696/the-global-burden-of-respiratory-disease
#17
Thomas Ferkol, Dean Schraufnagel
The Forum of International Respiratory Societies has released a report entitled Respiratory Disease in the World: Realities of Today-Opportunities for Tomorrow. The report identifies five conditions that primarily contribute to the global burden of respiratory disease (asthma, chronic obstructive pulmonary disease, acute respiratory infections, tuberculosis, and lung cancer), and offers an action plan to prevent and treat those diseases. It describes the staggering magnitude of the global burden of lung disease: hundreds of millions of people suffer and four million people die prematurely from respiratory diseases each year...
March 2014: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/24610581/the-global-burden-of-respiratory-disease-impact-on-child-health
#18
EDITORIAL
Heather J Zar, Thomas W Ferkol
Respiratory disease is the major cause of mortality and morbidity worldwide, with infants and young children especially susceptible. The spectrum of disease ranges from acute infections to chronic non-communicable diseases. Five respiratory conditions dominate-acute respiratory infections, chronic obstructive pulmonary disease, asthma, tuberculosis (TB), and lung cancer. Pneumonia remains the predominant cause of childhood mortality, causing nearly 1.3 million deaths each year, most of which are preventable...
May 2014: Pediatric Pulmonology
https://www.readbyqxmd.com/read/23891511/history-of-lung-disease-and-risk-of-lung-cancer-in-a-population-with-high-household-fuel-combustion-exposures-in-rural-china
#19
H Dean Hosgoodiii, Robert S Chapman, Xingzhou He, Wei Hu, Linwei Tian, Larry Z Liu, Hong Lai, Wei Chen, Nathaniel Rothman, Qing Lan
History of chronic lung diseases and household coal use for heating and cooking are established risk factors of lung cancer; however, few studies have been able to explore these risk factors simultaneously. Xuanwei, China, has some of the highest rates of lung cancer in China and most residents experience substantial in-home coal smoke exposures. Using a population-based case-control study of 498 lung cancer cases and 498 age-matched controls, we evaluated the risk of lung cancer in relation to coal smoke exposure and history of chronic lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, tuberculosis (TB), chronic bronchitis, and emphysema...
September 2013: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/23856439/comorbidities-and-health-status-in-individuals-with-and-without-copd-in-five-latin-american-cities-the-platino-study
#20
MULTICENTER STUDY
Maria Victorina López Varela, María Montes de Oca, Ronald Halbert, Adriana Muiño, Carlos Tálamo, Rogelio Pérez-Padilla, José Roberto B Jardim, Gonzalo Valdivia, Julio Pertuzé, Ana María B Menezes
INTRODUCTION: Comorbidities are common in patients with chronic obstructive pulmonary disease (COPD), and have a significant impact on health status and prognosis. The PLATINO study provides data on self-reported comorbidities and perceived health status in COPD subjects. METHODS: PLATINO is a population-based study on COPD prevalence in five Latin American cities. COPD diagnosis was defined by GOLD criteria (FEV1/FVC<.70 post-bronchodilator). Information was collected on the following comorbidities: heart disease, hypertension, diabetes, cerebrovascular disease, peptic ulcer and asthma...
November 2013: Archivos de Bronconeumología
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