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dengue and pregnancy

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https://www.readbyqxmd.com/read/29779827/zika-virus-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#1
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Pravin Amin
Zika fever is an acute infectious disease caused by the Zika virus (ZIKV), an RNA virus belonging to the genus Flavivirus. ZIKV can be transmitted by bites from Aedes aegypti and Aedes albopictus species, sexual activity, blood transfusion and from mother to fetus during pregnancy and delivery. A total of 50 territories and countries in the Americas had reported ZIKV infections. For those with symptoms, the presentation is similar to dengue fever with body aches, joint pain, fatigue, malaise, fever and conjunctivitis lasting up to seven days...
April 5, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29773774/us-and-cuban-scientists-forge-collaboration-on-arbovirus-research
#2
Jorge Pérez-Ávila, Maria G Guzmán-Tirado, Jorge Fraga-Nodarse, Gray Handley, James Meegan, Jose L Pelegrino-Martínez de la Cotera, Anthony S Fauci
After December 17, 2014, when the US and Cuban governments announced their intent to restore relations, the two countries participated in various exchange activities in an effort to encourage cooperation in public health, health research and biomedical sciences. The conference entitled Exploring Opportunities for Arbovirus Research Collaboration, hosted at Havana's Hotel Nacional, was part of these efforts and was the first major US-Cuban scientific conference in over 50 years. Its purpose was to share information about current arbovirus research and recent findings, and to explore opportunities for future joint research...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29744330/splenic-hematoma-mimicking-rupture-uterus-a-diagnostic-dilemma
#3
Vishnu Bhartiya, Richa Sharma
Spontaneous splenic hematoma occurring during pregnancy is a rare entity. It often occurs in preexisting pathology of the spleen such as thalassemia or infectious etiologies such as malaria, typhoid, dengue, or infectious mononucleosis but most commonly after a trauma. The occurrence of splenic hematoma during pregnancy without any underlying cause is rare. Here, we present such a case and the diagnostic dilemma associated with it.
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29716774/dengue-vaccination-during-pregnancy-an-overview-of-clinical-trials-data
#4
Anna Skipetrova, Tram Anh Wartel, Sophia Gailhardou
BACKGROUND: The live, attenuated, tetravalent dengue vaccine (CYD-TDV) is licensed in several endemic countries and contraindicated during pregnancy. Inadvertent vaccination during pregnancy may occur during clinical trials that include women of childbearing age. The potential risk associated with dengue vaccination in pregnancy remains unknown. We describe pregnancy outcomes following inadvertent dengue vaccination in pregnancy from CYD-TDV trial data. METHODS: Data were collected from trials conducted as part of the CYD-TDV clinical development...
April 28, 2018: Vaccine
https://www.readbyqxmd.com/read/29692297/estimating-the-risk-of-vertical-transmission-of-dengue-a-prospective-study
#5
Célia Basurko, Séverine Matheus, Hélène Hildéral, Sibille Everhard, Marion Restrepo, Emma Cuadro-Alvarez, Véronique Lambert, Rachida Boukhari, Jean-Pierre Duvernois, Anne Favre, Mathieu Nacher, Gabriel Carles
The incidence of dengue worldwide is increasing rapidly. A better understanding of dengue transmission may help improve interventions against this major public health problem. The virus is mostly transmitted by vectors. There are, however, other modes of transmission, notably mother-to-child transmission or vertical transmission. We studied a prospective cohort of 54 women who had dengue while pregnant during the 2012-2013 epidemic in French Guiana to estimate the mother-to-child transmission rate and assess the clinical and biological presentation of neonatal dengue...
April 23, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29623138/clinical-serological-and-molecular-observations-from-a-case-series-study-during-the-asian-lineage-zika-virus-outbreak-in-grenada-during-2016
#6
Marco Brenciaglia, Trevor P Noël, Paul J Fields, Satesh Bidaisee, Todd E Myers, William M Nelson, Neeraja Venkateswaran, Kodumudi Venkateswaran, Nishanth Parameswaran, Avi Bahadoor, Katherine Yearwood, Veronica Mapp-Alexander, George Mitchell, A Desiree LaBeaud, Calum N L Macpherson
This paper describes the spatial and temporal distribution of cases, demographic characteristics of patients, and clinical manifestations of Zika virus (ZIKV) during the 2016 outbreak in Grenada. The first reported case was recorded in St. Andrew Parish in April, and the last reported case was seen in November, with peak transmission occurring in the last week of June, based on test results. Data were collected from a total of 514 patients, of whom 207 (40%) tested positive for ZIKV. No evidence was found that testing positive for ZIKV infection was related to age, gender, or pregnancy status...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29607328/maternal-fetal-and-neonatal-outcomes-in-pregnant-dengue-patients-in-mexico
#7
Carlos Machain-Williams, Eric Raga, Carlos M Baak-Baak, Sungmin Kiem, Bradley J Blitvich, Celso Ramos
To increase our understanding of the consequences of dengue virus infection during pregnancy, a retrospective analysis was performed on the medical records of all completed pregnancies (live births and pregnancy losses) at nine public hospitals in the Gulf of Mexico from January to October 2013. Eighty-two patients developed clinical, laboratory-confirmed dengue virus infections while pregnant. Of these, 54 (65.9%) patients were diagnosed with dengue without warning signs, 15 (18.3%) patients were diagnosed with dengue with warning signs, and 13 (15...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29546926/-perinatal-dengue-a-case-report
#8
Ramiro Manzano Núñez, James Alejandro Zapata, Herney A García-Perdomo, Diego A Gomez, Mónica A Solís Velasco
INTRODUCTION: Few reports are available about perinatal dengue, with controversial results in regards the risk of perinatal outcome. OBJECTIVE: To report a case of perinatal dengue as a differential diagno sis with neonatal sepsis, which must be considered in endemic areas. CLINICAL CASE: Male newborn of a 23 year-old female, who presented a Non-Structural Protein 1 (NS1) antigen positive to dengue at 36 weeks of gestation and negative anti-dengue antibodies...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29416874/optimization-of-commercially-available-zika-virus-antibodies-for-use-in-a-laboratory-developed-immunohistochemical-assay
#9
Brigid C Bollweg, Luciana Silva-Flannery, Pamela Spivey, Gillian L Hale
Zika virus (ZIKV) infection during pregnancy can cause adverse fetal outcomes and severe irreversible congenital birth defects including microcephaly. Immunohistochemistry (IHC) is a valuable diagnostic tool for detecting ZIKV antigens in tissues from cases of fetal loss in women infected with ZIKV, and for providing insights into disease pathogenesis. As a result, there is increasing demand for commercially available ZIKV antibodies for use in IHC assays. ZIKV antibodies were selected and obtained from commercial sources to include both mouse and rabbit hosts, and a variety of antigenic targets...
January 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29412347/microcephaly-in-piau%C3%A3-brazil-descriptive-study-during-the-zika-virus-epidemic-2015-2016
#10
Igor Gonçalves Ribeiro, Marcia Regina de Andrade, Janaína de Moraes Silva, Zenira Martins Silva, Maria Amélia de Oliveira Costa, Marcelo Adriano da Cunha E Silva Vieira, Francisca Miriane de Araújo Batista, Herlon Guimarães, Marcelo Yoshito Wada, Eduardo Saad
OBJECTIVE: to describe the occurrence and characteristics of microcephaly cases in Piauí, Brazil, during an epidemic of Zika virus infection in 2015-2016. METHODS: descriptive study using data of live births from January/2015 to January/2016, obtained from the Information System on Live Births (Sinasc), the Public Health Events Registry (RESP) and the active search for medical records; mothers and live births were tested for dengue, chikungunya, and Zika, besides syphilis, toxoplasmosis, rubella, cytomegalovirus, and herpes (STORCH)...
February 1, 2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29398694/when-epidemiology-is-the-clue-to-a-positive-outcome-a-case-of-malaria-during-pregnancy
#11
Daniela F de Lima Corvino, Aditya A Chandorkar, Andres L Mora Carpio, Antonette Climaco
BACKGROUND Malaria infection during pregnancy is associated with increased perinatal and maternal morbidity and mortality. CASE REPORT A 29-year-old primigravida at 37 weeks of gestation, with no significant medical history, presented complaining of fever, chills, and generalized body aches. She had been living in Malawi for 1 year and was on atovaquone/proguanil prophylaxis until she was found to be pregnant. Prophylaxis was changed to mefloquine and discontinued upon her return to the US. Six weeks prior to presentation, she traveled to Malawi for 1 month when she was off prophylaxis...
February 5, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29363451/case-report-an-acute-chikungunya-infection-and-a-recent-secondary-dengue-infection-in-a-peripartum-case-in-ecuador
#12
Daniel F Farrell, Christina D Lupone, Aileen Kenneson, Cinthya Cueva, Naveed Heydari, Julio H Barzallo Aguilera, Mark Polhemus, Timothy P Endy, Anna M Stewart-Ibarra
Dengue virus (DENV) and chikungunya virus (CHIKV) are transmitted by the same mosquito vectors and now co-circulate in many parts of the world; however, coinfections and serial infections are not often diagnosed or reported. A 38-week pregnant woman was admitted to the hospital with a diagnosis of suspected DENV and CHIKV in southern coastal Ecuador. The pregnancy was complicated by mild polyhydramnios and fetal tachycardia, and a healthy newborn was born. The patient was positive for a recent secondary DENV infection (Immunoglobulin M and Immunoglobulin G positive) and an acute CHIKV infection (real-time reverse transcriptase polymerase chain reaction positive) (Asian genotype)...
March 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29305550/comparison-of-four-serological-methods-and-two-reverse-transcription-pcr-assays-for-diagnosis-and-surveillance-of-zika-virus-infection
#13
Angel Balmaseda, José Victor Zambrana, Damaris Collado, Nadezna García, Saira Saborío, Douglas Elizondo, Juan Carlos Mercado, Karla Gonzalez, Cristhiam Cerpas, Andrea Nuñez, Davide Corti, Jesse J Waggoner, Guillermina Kuan, Raquel Burger-Calderon, Eva Harris
Zika virus (ZIKV) is a mosquito-borne flavivirus that is responsible for recent explosive epidemics in the Americas. Notably, ZIKV infection during pregnancy has been found to cause congenital birth defects, including microcephaly, and ZIKV has been associated with Guillain-Barré syndrome in adults. Diagnosis and surveillance of Zika in the Americas have been challenging due to similar clinical manifestations and extensive antibody cross-reactivity with endemic flaviviral diseases, such as dengue. We evaluated four serological and two reverse transcription-PCR (RT-PCR) methods in acute-phase (mean day, 1...
March 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29288700/erythrosin-b-is-a-potent-and-broad-spectrum-orthosteric-inhibitor-of-the-flavivirus-ns2b-ns3-protease
#14
Zhong Li, Srilatha Sakamuru, Ruili Huang, Matthew Brecher, Cheri A Koetzner, Jing Zhang, Haiying Chen, Cheng-Feng Qin, Qing-Yu Zhang, Jia Zhou, Laura D Kramer, Menghang Xia, Hongmin Li
Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1-4) and yellow fever virus (YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito-borne flavivirus, is associated with increased risk of microcephaly in newborns and Guillain-Barré syndrome and other complications in adults. Currently, specific therapy does not exist for any flavivirus infections. In this study, we found that erythrosin B, an FDA-approved food additive, is a potent inhibitor for flaviviruses, including ZIKV and DENV2...
February 2018: Antiviral Research
https://www.readbyqxmd.com/read/29242091/association-between-microcephaly-zika-virus-infection-and-other-risk-factors-in-brazil-final-report-of-a-case-control-study
#15
Thalia Velho Barreto de Araújo, Ricardo Arraes de Alencar Ximenes, Demócrito de Barros Miranda-Filho, Wayner Vieira Souza, Ulisses Ramos Montarroyos, Ana Paula Lopes de Melo, Sandra Valongueiro, Maria de Fátima Pessoa Militão de Albuquerque, Cynthia Braga, Sinval Pinto Brandão Filho, Marli Tenório Cordeiro, Enrique Vazquez, Danielle di Cavalcanti Souza Cruz, Claudio Maierovitch Pessanha Henriques, Luciana Caroline Albuquerque Bezerra, Priscila Mayrelle da Silva Castanha, Rafael Dhalia, Ernesto Torres Azevedo Marques-Júnior, Celina Maria Turchi Martelli, Laura Cunha Rodrigues
BACKGROUND: A Zika virus epidemic emerged in northeast Brazil in 2015 and was followed by a striking increase in congenital microcephaly cases, triggering a declaration of an international public health emergency. This is the final report of the first case-control study evaluating the potential causes of microcephaly: congenital Zika virus infection, vaccines, and larvicides. The published preliminary report suggested a strong association between microcephaly and congenital Zika virus infection...
March 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29235969/chikungunya-dengue-co-infection-during-pregnancy-requiring-preterm-caesarean-section-first-case-report-from-bangladesh
#16
Muhammad Abdur Rahim, Shahana Zaman, Nasreen Sultana, Ariful Islam, Khwaja Nazim Uddin
We report the first case of chikungunya-dengue co-infection during pregnancy requiring emergency Caesarean section (CS) because of fetal distress in a Bangladeshi primigravida. Though previously unreported, this situation may become increasingly common.
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29138300/high-zika-virus-seroprevalence-in-salvador-northeastern-brazil-limits-the-potential-for-further-outbreaks
#17
Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebastian Funk, Adam J Kucharski, Alexandra Rockstroh, Beate M Kümmerer, Gilmara Souza Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country, yet population exposure remains unknown. Serological studies of ZIKV are hampered by cross-reactive immune responses against heterologous viruses. We conducted serosurveys for ZIKV, dengue virus (DENV), and Chikungunya virus (CHIKV) in 633 individuals prospectively sampled during 2015 to 2016, including microcephaly and non-microcephaly pregnancies, HIV-infected patients, tuberculosis patients, and university staff in Salvador in northeastern Brazil using enzyme-linked immunosorbent assays (ELISAs) and plaque reduction neutralization tests...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29133154/adverse-birth-outcomes-associated-with-zika-virus-exposure-during-pregnancy-in-s%C3%A3-o-jos%C3%A3-do-rio-preto-brazil
#18
M L Nogueira, N R R Nery Júnior, C F Estofolete, A C Bernardes Terzian, G F Guimarães, N Zini, R Alves da Silva, G C Dutra Silva, L C Junqueira Franco, P Rahal, C Bittar, B Carneiro, P F C Vasconcelos, D Freitas Henriques, D M U Barbosa, P Lopes Rombola, L de Grande, A F Negri Reis, S A Palomares, M Wakai Catelan, L E A A Cruz, S H Necchi, R C V Mendonça, I N Penha Dos Santos, S B Alavarse Caron, F Costa, F A Bozza, A Soares de Souza, C C Brandão de Mattos, L C de Mattos, N Vasilakis, A H Oliani, D C M Vaz Oliani, A I Ko
OBJECTIVES: We aimed to report the first 54 cases of pregnant women infected by Zika virus (ZIKV) and their virologic and clinical outcomes, as well as their newborns' outcomes, in 2016, after the emergence of ZIKV in dengue-endemic areas of São Paulo, Brazil. METHODS: This descriptive study was performed from February to October 2016 on 54 quantitative real-time PCR ZIKV-positive pregnant women identified by the public health authority of São José do Rio Preto, São Paulo, Brazil...
November 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29112671/travel-characteristics-and-pretravel-health-care-among-pregnant-or-breastfeeding-u-s-women-preparing-for-international-travel
#19
Stefan H F Hagmann, Sowmya R Rao, Regina C LaRocque, Stefanie Erskine, Emily S Jentes, Allison T Walker, Elizabeth D Barnett, Lin H Chen, Davidson H Hamer, Edward T Ryan
OBJECTIVE: To study characteristics and preventive interventions of adult pregnant and breastfeeding travelers seeking pretravel health care in the United States. METHODS: This cross-sectional study analyzed data (2009-2014) of pregnant and breastfeeding travelers seen at U.S. travel clinics participating in Global TravEpiNet. Nonpregnant, nonbreastfeeding adult female travelers of childbearing age were used for comparison. We evaluated the prescription of malaria chemoprophylaxis and antibiotics for this population as well as the administration of three travel-related vaccines: hepatitis A, typhoid, and yellow fever...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29081814/roles-of-interferons-in-pregnant-women-with-dengue-infection-protective-or-dangerous-factors
#20
REVIEW
Hao Zhang, Zhiyi He, Wenting Zeng, Hong-Juan Peng
Dengue infection is a serious public health problem in tropical and subtropical areas. With the recent outbreaks of Zika disease and its reported correlation with microcephaly, the large number of pregnancies with dengue infection has become a serious concern. This review describes the epidemiological characteristics of pregnancy with dengue and the initial immune response to dengue infection, especially in IFNs production in this group of patients. Dengue is much more prevalent in pregnant women compared with other populations...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
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