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https://www.readbyqxmd.com/read/27902502/zika-virus-and-patient-blood-management
#1
Lawrence T Goodnough, Marisa B Marques
Sporadic Zika virus infections had only occurred in Africa and Asia until an outbreak in Micronesia (Oceania) in 2007. In 2013 to 2014, several outer Pacific Islands reported local outbreaks. Soon thereafter, the virus was likely introduced in Brazil from competing athletes from French Polynesia and other countries that participated in a competition there. Transmission is thought to have occurred through mosquito bites and spread to the immunologically naive population. Being also a flavivirus, the Zika virus is transmitted by the Aedes mosquito that is endemic in South and Central America that is also the vector of West Nile virus, dengue, and chikungunya...
November 29, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27729840/virtual-screening-for-potential-inhibitors-of-ns3-protein-of-zika-virus
#2
Maheswata Sahoo, Lingaraja Jena, Sangeeta Daf, Satish Kumar
Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause microcephaly, a serious birth defect during pregnancy. The recent outbreak of ZIKV in February 2016 in Brazil realized it as a major health risk, demands an enhanced surveillance and a need to develop novel drugs against ZIKV. Amodiaquine, prochlorperazine, quinacrine, and berberine are few promising drugs approved by Food and Drug Administration against dengue virus which also belong to Flaviviridae family...
September 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/27693308/zika-virus-infection-induces-cranial-neural-crest-cells-to-produce-cytokines-at-levels-detrimental-for-neurogenesis
#3
Nicholas L Bayless, Rachel S Greenberg, Tomek Swigut, Joanna Wysocka, Catherine A Blish
Zika virus (ZIKV) infection during pregnancy is linked to microcephaly, which is attributed to infection of developing brain structures. ZIKV infects neural progenitor cells in vitro, though its effects on other developmentally relevant stem cell populations, including cranial neural crest cells (CNCCs), have not been assessed. CNCCs give rise to most cranial bones and exert paracrine effects on the developing brain. Here, we report that CNCCs are productively infected by ZIKV, but not by the related dengue virus...
October 12, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27641777/association-between-zika-virus-infection-and-microcephaly-in-brazil-january-to-may-2016-preliminary-report-of-a-case-control-study
#4
Thalia Velho Barreto de Araújo, Laura Cunha Rodrigues, Ricardo Arraes de Alencar Ximenes, Demócrito de Barros Miranda-Filho, Ulisses Ramos Montarroyos, Ana Paula Lopes de Melo, Sandra Valongueiro, Maria de Fátima Pessoa Militão de Albuquerque, Wayner Vieira Souza, Cynthia Braga, Sinval Pinto Brandão Filho, Marli Tenório Cordeiro, Enrique Vazquez, Danielle Di Cavalcanti Souza Cruz, Cláudio Maierovitch Pessanha Henriques, Luciana Caroline Albuquerque Bezerra, Priscila Mayrelle da Silva Castanha, Rafael Dhalia, Ernesto Torres Azevedo Marques-Júnior, Celina Maria Turchi Martelli
BACKGROUND: The microcephaly epidemic, which started in Brazil in 2015, was declared a Public Health Emergency of International Concern by WHO in 2016. We report the preliminary results of a case-control study investigating the association between microcephaly and Zika virus infection during pregnancy. METHODS: We did this case-control study in eight public hospitals in Recife, Brazil. Cases were neonates with microcephaly. Two controls (neonates without microcephaly), matched by expected date of delivery and area of residence, were selected for each case...
September 15, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27526349/miscarriage-following-dengue-virus-3-infection-in-the-first-six-weeks-of-pregnancy-of-a-dengue-virus-naive-traveller-returning-from-bali-to-italy-april-2016
#5
Maurizio Zavattoni, Francesca Rovida, Giulia Campanini, Elena Percivalle, Antonella Sarasini, Graziella Cristini, Lina Rachele Tomasoni, Francesco Castelli, Fausto Baldanti
We report miscarriage following dengue virus (DENV)-3 infection in a pregnant woman returning from Bali to Italy in April 2016. On her arrival, the woman had fever, rash, asthenia and headache. DENV RNA was detected in plasma and urine samples collected the following day. Six days after symptom onset, she had a miscarriage. DENV RNA was detected in fetal material, but in utero fetal infection cannot be demonstrated due to possible contamination by maternal blood.
August 4, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27490087/update-ongoing-zika-virus-transmission-puerto-rico-november-1-2015-july-7-2016
#6
Laura Adams, Melissa Bello-Pagan, Matthew Lozier, Kyle R Ryff, Carla Espinet, Jomil Torres, Janice Perez-Padilla, Mitchelle Flores Febo, Emilio Dirlikov, Alma Martinez, Jorge Munoz-Jordan, Myriam Garcia, Marangely Olivero Segarra, Graciela Malave, Aidsa Rivera, Carrie Shapiro-Mendoza, Asher Rosinger, Matthew J Kuehnert, Koo-Whang Chung, Lisa L Pate, Angela Harris, Ryan R Hemme, Audrey Lenhart, Gustavo Aquino, Sherif Zaki, Jennifer S Read, Stephen H Waterman, Luisa I Alvarado, Francisco Alvarado-Ramy, Miguel Valencia-Prado, Dana Thomas, Tyler M Sharp, Brenda Rivera-Garcia
Zika virus is a flavivirus transmitted primarily by Aedes aegypti and Aedes albopictus mosquitoes, and infection can be asymptomatic or result in an acute febrile illness with rash (1). Zika virus infection during pregnancy is a cause of microcephaly and other severe birth defects (2). Infection has also been associated with Guillain-Barré syndrome (GBS) (3) and severe thrombocytopenia (4,5). In December 2015, the Puerto Rico Department of Health (PRDH) reported the first locally acquired case of Zika virus infection...
2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27467271/preventing-zika-virus-infection-during-pregnancy-using-a-seasonal-window-of-opportunity-for-conception
#7
Micaela Elvira Martinez
It has come to light that Zika virus (ZIKV) infection during pregnancy can result in trans-placental transmission to the fetus along with fetal death, congenital microcephaly, and/or Central Nervous System (CNS) malformations. There are projected to be >9,200,000 births annually in countries with ongoing ZIKV transmission. In response to the ZIKV threat, the World Health Organization (WHO) is strategically targeting prevention of infection in pregnant women and funding contraception in epidemic regions. I propose that the damaging effects of ZIKV can be reduced using a seasonal window of opportunity for conception that may minimize maternal exposure...
July 2016: PLoS Biology
https://www.readbyqxmd.com/read/27412976/zika-virus-infections
#8
F de Laval, I Leparc-Goffart, J-B Meynard, H Daubigny, F Simon, S Briolant
Since its discovery in 1947 in Uganda, the Zika virus (ZIKV) remained in the shadows emerging in 2007 in Micronesia, where hundreds of dengue-like syndromes were reported. Then, in 2013-2014, it was rife in French Polynesia, where the first neurological effects were observed. More recently, its arrival in Brazil was accompanied by an unusually high number of children with microcephaly born to mothers infected with ZIKV during the first trimester of pregnancy. In 2016, the World Health Organization declared ZIKV infection to be a public health emergency and now talks about a ZIKV pandemic...
May 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/27384840/dengue-as-a-cause-of-fever-during-pregnancy-a-report-of-two-cases
#9
Ariani Impieri Souza, Ana Laura Carneiro Gomes Ferreira, Matheus Alencar Arraes, Bruno Marcelo Moura, Maria Cynthia Braga
Dengue infection has not been routinely investigated among pregnant women and parturients with acute febrile syndrome in endemic settings. Here, we report two cases of dengue fever detected at the time of delivery in parturients enrolled in a cohort prospective study conducted in a hospital in Recife, Brazil. The parturients reported fever onset within seven days prior to delivery, and dengue infection was confirmed upon detection of viral ribonucleic acid (RNA) by using the reverse transcriptase-polymerase chain reaction...
May 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27366586/using-phenomenological-models-to-characterize-transmissibility-and-forecast-patterns-and-final-burden-of-zika-epidemics
#10
Gerardo Chowell, Doracelly Hincapie-Palacio, Juan Ospina, Bruce Pell, Amna Tariq, Sushma Dahal, Seyed Moghadas, Alexandra Smirnova, Lone Simonsen, Cécile Viboud
BACKGROUND: The World Health Organization declared the ongoing Zika virus (ZIKV) epidemic in the Americas a Public Health Emergency of International Concern on February 1, 2016. ZIKV disease in humans is characterized by a "dengue-like" syndrome including febrile illness and rash. However, ZIKV infection in early pregnancy has been associated with severe birth defects, including microcephaly and other developmental issues. Mechanistic models of disease transmission can be used to forecast trajectories and likely disease burden but are currently hampered by substantial uncertainty on the epidemiology of the disease (e...
2016: PLoS Currents
https://www.readbyqxmd.com/read/27323550/zika-virus-infection-vertical-transmission-and-foetal-congenital-anomalies
#11
EDITORIAL
Aziz-un-Nisa Abbasi
Zika virus (ZIKV) is an arbovirus belonging to flaviviridae family that includes Dengue, West Nile, and Yellow Fever among others. Zika virus was first discovered in 1947 in Zika forest of Uganda. It is a vector borne disease, which has been sporadically reported mostly from Africa, Pacific islands and Southeast Asia since its discovery. ZIKV infection presents as a mild illness with symptoms lasting for several days to a week after the bite of an infected mosquito. Majority of the patients have low grade fever, rash, headaches, joints pain, myalgia, and flu like symptoms...
January 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/27257326/dengue-chikungunya-%C3%A2-and-the-missing-entity-zika-fever-a-new-emerging-threat
#12
REVIEW
Rina Tilak, Sougat Ray, V W Tilak, Sandip Mukherji
Zika virus (ZIKV), a relative newcomer from the flavivirus group that includes dengue, Japanese encepahalitis and yellow fever, is one of the emerging pathogens that is fast transcending geographical boundaries. It is a vector-borne disease transmitted by the same Aedes aegypti and Aedes albopictus, which cause dengue and chikungunya. In addition to the vector-mediated transmission of Zika fever, probable human-to-human transmission through exchange of body fluids, including sexual and perinatal transmission and through blood transfusion, makes containment of this new entity more challenging...
April 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27236271/expanded-spectrum-of-congenital-ocular-findings-in-microcephaly-with-presumed-zika-infection
#13
Homero Augusto de Miranda, Marcelo Cavalcante Costa, Maria Auxiliadora Monteiro Frazão, Natália Simão, Sandra Franchischini, Darius M Moshfeghi
PURPOSE: To describe the ocular findings of 3 cases of suspected congenital Zika viral infection with microcephaly and maculopathy. DESIGN: Retrospective, consecutive case series. PARTICIPANTS: Three male infants born in northern Brazil whose mothers demonstrated a viral syndrome during the first trimester and who subsequently were born with microcephaly. METHODS: Observational report of macular findings. MAIN OUTCOME MEASURES: Continued observation...
August 2016: Ophthalmology
https://www.readbyqxmd.com/read/27149205/update-ongoing-zika-virus-transmission-puerto-rico-november-1-2015-april-14-2016
#14
Emilio Dirlikov, Kyle R Ryff, Jomil Torres-Aponte, Dana L Thomas, Janice Perez-Padilla, Jorge Munoz-Jordan, Elba V Caraballo, Myriam Garcia, Marangely Olivero Segarra, Graciela Malave, Regina M Simeone, Carrie K Shapiro-Mendoza, Lourdes Romero Reyes, Francisco Alvarado-Ramy, Angela F Harris, Aidsa Rivera, Chelsea G Major, Marrielle Mayshack, Luisa I Alvarado, Audrey Lenhart, Miguel Valencia-Prado, Steve Waterman, Tyler M Sharp, Brenda Rivera-Garcia
Zika virus is a flavivirus transmitted primarily by Aedes species mosquitoes, and symptoms of infection can include rash, fever, arthralgia, and conjunctivitis (1).* Zika virus infection during pregnancy is a cause of microcephaly and other severe brain defects (2). Infection has also been associated with Guillain-Barré syndrome (3). In December 2015, Puerto Rico became the first U.S. jurisdiction to report local transmission of Zika virus, with the index patient reporting symptom onset on November 23, 2015 (4)...
2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27069349/spectrum-of-maternofetal-outcomes-during-dengue-infection-in-pregnancy-an-insight
#15
Swati Sharma, Sandhya Jain, Shalini Rajaram
Dengue is a vector transmitted viral infection; tropical and subtropical countries see outbreaks of dengue each year. There is a paucity of literature on effects of dengue infection on pregnancy outcome and this prompted us to undertake a study for better understanding of pregnancy implications with dengue infection. Pregnant women admitted during the seasonal outbreak of dengue between September 2015 and October 2015 were studied and maternal and fetal outcomes in sixteen NS1Ag positive women were analysed...
2016: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27052792/why-zika-virus-infection-has-become-a-public-health-concern
#16
REVIEW
Hui-Lan Chen, Ren-Bin Tang
Prior to 2015, Zika Virus (ZIKV) outbreaks had occurred in areas of Africa, Southeast Asia, and the Pacific Islands. Although a causal relationship between Zika infection during pregnancy and microcephaly is strongly suspected, such a connection has not yet been scientifically proven. In May 2015, the outbreak of ZIKV infection in Brazil led to reports of syndrome and pregnant women giving birth to babies with birth defects and poor pregnancy outcomes; the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed ZIKV infection in Brazil...
April 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27050192/the-aetiologies-and-impact-of-fever-in-pregnant-inpatients-in-vientiane-laos
#17
Vilada Chansamouth, Syvilay Thammasack, Rattanaphone Phetsouvanh, Valy Keoluangkot, Catrin E Moore, Stuart D Blacksell, Josee Castonguay-Vanier, Audrey Dubot-Pérès, Jarasporn Tangkhabuanbutra, Narongchai Tongyoo, Phooksavanh Souphaphonh, Onanong Sengvilaipaseuth, Manivanh Vongsouvath, Koukeo Phommasone, Davanh Sengdethka, Amphayvanh Seurbsanith, Scott B Craig, Laura Hermann, Michel Strobel, Paul N Newton
INTRODUCTION: Laos has the highest maternal mortality ratio in mainland Southeast Asia and a high incidence of infectious diseases. Globally, malaria has been the pathogen most intensively investigated in relation to impact on pregnancy, but there has been relatively little research on the aetiology and impact of other diseases. We therefore aimed to determine the causes and impact of fever in pregnant women admitted to two central hospitals in Vientiane City, Lao PDR (Laos). MATERIALS AND METHODS: This hospital-based prospective study was conducted in Mahosot Hospital and the Mother and Child Hospital, Vientiane, between 2006 and 2010, with the aim to recruit 250 consenting pregnant women admitted with tympanic temperature ≥37...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27042608/can-radiology-play-a-role-in-early-diagnosis-of-dengue-fever
#18
Shruti Chandak, Ashutosh Kumar
BACKGROUND: Dengue fever (DF) is a viral hemorrhagic fever causing severe morbidity and mortality in affected patients. AIMS: The purpose of our study was to evaluate the changing trends in radiological findings in DF, to find if ultrasound is useful in the diagnosis of DF during an epidemic in absence of serological tests, and also to investigate the effects of DF in pregnancy. MATERIALS AND METHODS: A prospective study was conducted in 2013 comprising of 400 patients who were serologically positive for dengue...
February 2016: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/27020989/zika-virus-and-the-current-outbreak-an-overview
#19
M Goeijenbier, L Slobbe, A van der Eijk, M de Mendonça Melo, M P G Koopmans, C B E M Reusken
Zika virus (ZIKV), a mosquito-borne flavivirus closely related to yellow fever virus and dengue virus, is currently causing a large outbreak in the Americas. Historically, ZIKV infection was considered a sporadic, relatively mild disease characterised by fever, maculopapular rash, conjunctivitis and often arthralgia. However, current observational studies suggest that ZIKV may cause more severe neurological sequelae such as Guillain-Barre syndrome, and birth defects, mainly microcephaly, in babies of whom the mother was infected with ZIKV during pregnancy...
March 2016: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/26988170/epidemiology-and-neurological-complications-of-infection-by-the-zika-virus-a-new-emerging-neurotropic-virus
#20
Francisco J Carod-Artal
INTRODUCTION: The current epidemic outbreak due to Zika virus began in 2015 and since then it has been reported in 31 countries and territories in America. The epidemiological and clinical aspects related to infection by Zika virus are reviewed. DEVELOPMENT: Since 2007, 55 countries in America, Asia, Africa and Oceania have detected local transmission of the virus. This epidemic has affected almost 1.5 million people in Brazil. 80% of the cases are asymptomatic...
April 1, 2016: Revista de Neurologia
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