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Atsushi Miyajima, Takashi Hirota, Mari Tashiro, Wataru Noguchi, Yayoi Kawano, Takehisa Hanawa, Akira Kigure, Taichi Anata, Yosuke Yamamoto, Nae Yuasa, Machi Koshino, Yumi Shiraishi, Kaoru Yuzawa, Keita Akagi, Takashi Yoshimasu, Kuniko Makigami, Masayo Komoda
As a novel administration method of ivermectin (IVM) for scabies treatment, we proposed a "whole-body bathing method (WBBM)". In this method, the patients would bathe themselves in a bathing fluid containing IVM at an effective concentration. Previously, we demonstrated that WBBM could deliver IVM to the skin but not to the plasma in rats. In the present study, to assess the clinical validity of the method an arm bathing examination (first trial) and a whole-body bathing examination (second trial) were conducted in healthy volunteers...
October 15, 2016: Journal of Dermatology
Thanh M Bui, Alain Coron, Jonathan Mamou, Emi Saegusa-Beecroft, Tadashi Yamaguchi, Eugene Yanagihara, Junji Machi, S Lori Bridal, Ernest J Feleppa
OBJECTIVE: To detect metastases in freshly excised human lymph nodes (LNs) using 3-dimensional (3D), high-frequency, quantitative ultrasound (QUS) methods, the LN parenchyma (LNP) must be segmented to preclude QUS analysis of data in regions outside the LNP and to compensate ultrasound attenuation effects due to overlying layers of LNP and residual perinodal fat (PNF). METHODS: After restoring saturated radio-frequency signals from PNF using an approach based on smoothing-cubic splines, the three regions, i...
September 28, 2016: IEEE Transactions on Bio-medical Engineering
Seiichi Uno, Emiko Kokushi, Machi Kawano, Anne E McElroy, Jiro Koyama
Toxic risks of sediments collected from seven sites in Tokyo Bay were evaluated using Japanese medaka embryos. Those sediments with slight pore water were placed in grass petri dishes without overlying water. The most remarkable effect in the field sediment was to cause hatching delay in embryos, and the longest time until hatching took was 12.5 ± 1.6 days post-fertilization (dpf), although that in control group was 10.1 ± 0.7 dpf. A significant delay in hatching was observed at four sites. Because total carbon concentrations were relatively high in sediments at three of these four sites, several chemicals were expected to be residues in these sites and could cause their delay...
September 13, 2016: Environmental Science and Pollution Research International
Tadashi Konoshita, Saori Kaeriyama, Machi Urabe, Takahiro Nakaya, Mika Yamada, Mai Ichikawa, Katsushi Yamamoto, Satsuki Sato, Michiko Imagawa, Miki Fujii, Yasukazu Makino, Yasuo Zenimaru, Shigeyuki Wakahara, Jinya Suzuki, Tamotsu Ishizuka, Hiroyuki Nakamura
The activation of the renin-angiotensin system (RAS) is one of the unfavourable characteristics of calcium channel blocker (CCB). N type calcium channel is thought to be involved in renin gene transcription and adrenal aldosterone release. Accordingly, N/L type CCB has a possibility of less elevation of plasma aldosterone concentrations (PAC) among CCBs. In a monotherapy study, we had already demonstrated that N/L type CCB leads to less activation of the RAS compared with L type CCB. The objective of this study is to substantiate the hypothesis that at the condition of additive administration on the top of an angiotensin receptor blocker (ARB), still N/L type CCB leads to less elevation of PAC compared with L type one...
October 2016: Bioscience Reports
Yohei Koya, Shinya Uchida, Yoshiki Machi, Yuko Shobu, Noriyuki Namiki, Tsutomu Kotegawa
PURPOSE: AST-120 is used to decrease the abundance of serum uremic toxins in treatment of chronic kidney disease; however, it could also adsorb concomitantly administered drugs. This study aimed to develop a prediction method for drug interaction between AST-120 and concomitantly administered drugs based on in vitro dissolution and in vivo absorption behavior. METHODS: Sixty-eight drugs were selected for the analysis. For each drug, theoretical dissolution (R d) and absorption (R a) rates at estimated dosing intervals (1, 30, 60, 90, 120, and 240 min) were calculated using the Noyes-Whitney formula and compartment analysis, respectively...
November 2016: European Journal of Clinical Pharmacology
Toshihiko Machi
No abstract text is available yet for this article.
2016: Internal Medicine
Machi Suka, Asako Taniuchi, Suguru Igarashi, Hiroyuki Yanagisawa, Bunpei Ishizuka
OBJECTIVES: This study proposed a method for assessing menopause-specific health literacy (knowledge and beliefs about menopausal symptoms which aid their recognition, assessment, and management) using a vignette methodology. STUDY DESIGN: A cross-sectional web-based survey was conducted in September 2015 among Japanese women aged 30-59 years. Of 1236 women surveyed, 1196 eligible participants who were not under treatment for menopausal symptoms were included. MAIN OUTCOME MEASURES: Participants were presented with a vignette describing a woman with menopausal symptoms and were then asked a series of questions to assess their recognition of menopausal symptoms, attitude, subjective norm, perceived behavior control, availability, and intention to seek medical care if they themselves had the problems described in the vignette...
September 2016: Maturitas
Akiko Hashimoto-Tane, Machie Sakuma, Hiroshi Ike, Tadashi Yokosuka, Yayoi Kimura, Osamu Ohara, Takashi Saito
The immunological synapse (IS) formed at the interface between T cells and antigen-presenting cells represents a hallmark of initiation of acquired immunity. T cell activation is initiated at T cell receptor (TCR) microclusters (MCs), in which TCRs and signaling molecules assemble at the interface before IS formation. We found that each TCR-MC was transiently bordered by a ring structure made of integrin and focal adhesion molecules in the early phase of activation, which is similar in structure to the IS in microscale...
July 25, 2016: Journal of Experimental Medicine
Ryuji Fujihara, Yoichi Chiba, Toshitaka Nakagawa, Nozomu Nishi, Ryuta Murakami, Koichi Matsumoto, Machi Kawauchi, Tetsuji Yamamoto, Masaki Ueno
Their aim was to examine whether microvascular leakage of endogenous albumin, a representative marker for blood-brain barrier (BBB) damage, was induced in the periventricular area of diabetic db/db mice because periventricular white matter hyperintensity formation in magnetic resonance images was accelerating in elderly patients with diabetes mellitus. Using light and electron microscopes, and semi-quantitative analysis techniques, immunoreactivity of endogenous albumin, indicating vascular permeability, was examined in the periventricular area and spinal cord of db/db mice and db/+m control mice...
September 2016: Microscopy Research and Technique
Joichi Usui, Takashi Tawara-Iida, Kenji Takada, Itaru Ebihara, Atsushi Ueda, Satoshi Iwabuchi, Takashi Ishizu, Tadashi Iitsuka, Katsumi Takemura, Tetsuya Kawamura, Shuzo Kaneko, Kentaro Sakai, Hirayasu Kai, Tomoka Gomibuchi, Michio Nagata, Masaki Kobayashi, Akio Koyama, Machi Suka, Jai Radhakrishnan, Kunihiro Yamagata
BACKGROUND: The incidence of post-infectious glomerulonephritis (PIGN) in developed countries has decreased over the last 50 years. Here we identified the trends of the incidence of PIGN in Japan during the past four decades. METHODS: We explored the frequency, clinicopathological findings, and prognosis of PIGN based on 6,369 cases from the Renal Biopsy Database of our institute in the Kanto region of Japan, diagnosed histologically from 1976 to 2009. RESULTS: The numbers of PIGN cases were 131 (2...
2016: PloS One
D Abbott, P Adderley, A Adeyemi, P Aguilera, M Ali, H Areti, M Baylac, J Benesch, G Bosson, B Cade, A Camsonne, L S Cardman, J Clark, P Cole, S Covert, C Cuevas, O Dadoun, D Dale, H Dong, J Dumas, E Fanchini, T Forest, E Forman, A Freyberger, E Froidefond, S Golge, J Grames, P Guèye, J Hansknecht, P Harrell, J Hoskins, C Hyde, B Josey, R Kazimi, Y Kim, D Machie, K Mahoney, R Mammei, M Marton, J McCarter, M McCaughan, M McHugh, D McNulty, K E Mesick, T Michaelides, R Michaels, B Moffit, D Moser, C Muñoz Camacho, J-F Muraz, A Opper, M Poelker, J-S Réal, L Richardson, S Setiniyaz, M Stutzman, R Suleiman, C Tennant, C Tsai, D Turner, M Ungaro, A Variola, E Voutier, Y Wang, Y Zhang
The Polarized Electrons for Polarized Positrons experiment at the injector of the Continuous Electron Beam Accelerator Facility has demonstrated for the first time the efficient transfer of polarization from electrons to positrons produced by the polarized bremsstrahlung radiation induced by a polarized electron beam in a high-Z target. Positron polarization up to 82% have been measured for an initial electron beam momentum of 8.19  MeV/c, limited only by the electron beam polarization. This technique extends polarized positron capabilities from GeV to MeV electron beams, and opens access to polarized positron beam physics to a wide community...
May 27, 2016: Physical Review Letters
Akira Tadokoro, Nobuhiro Kanaji, Taiga Hara, Koichi Matsumoto, Tomoya Ishii, Takehiro Takagi, Naoki Watanabe, Nobuyuki Kita, Machi Kawauchi, Masaki Ueno, Norimitsu Kadowaki, Shuji Bandoh
No abstract text is available yet for this article.
September 2016: American Journal of Medicine
Machi Kawano, Seiichi Uno, Jiro Koyama, Emiko Kokushi, Anne McElroy
Oxygenated polycyclic aromatic hydrocarbons (oxyPAHs) are directly discharged into the atmosphere with exhaust gas from diesel engine automobiles and industry and are also generated by photo-oxidation and/or microbial metabolism of parent polycyclic aromatic hydrocarbons (PAHs). They are widely distributed in environment, especially around urban areas. We evaluated the effects of exposure to oxyPAHs as acenaphthenequinone (ANQ), 7,12-benz(a)anthracenequinone (BAQ), 1,4-naphthoquinone (NAQ), and 9,10-phenanethrenequinone (PHQ) in Japanese medaka (Oryzias latipes) embryos...
May 27, 2016: Environmental Science and Pollution Research International
Ryuta Murakami, Yoichi Chiba, Kazuhito Tsuboi, Koichi Matsumoto, Machi Kawauchi, Ryuji Fujihara, Masato Mashima, Kenji Kanenishi, Tetsuji Yamamoto, Masaki Ueno
High fructose intake is known to be associated with increased plasma triglyceride concentration, impaired glucose tolerance, insulin resistance, and high blood pressure. In addition, excess fructose intake is also thought to be a risk factor for dementia. Previous immunohistochemical studies have shown the presence of glucose transporter 5 (GLUT5), a major transporter of fructose, in the epithelial cells of the choroid plexus and ependymal cells in the brains of humans, rats, and mice, while GLUT2, a minor transporter of fructose, was localized in the ependymal cells of rat brain...
August 2016: Histochemistry and Cell Biology
Cyril Dargazanli, Valérie Rigau, Omer Eker, Carlos Riquelme Bareiro, Paolo Machi, Grégory Gascou, Caroline Arquizan, Xavier Ayrignac, Isabelle Mourand, Astrid Corlobé, Kyriakos Lobotesis, Nicolas Molinari, Valérie Costes, Alain Bonafé, Vincent Costalat
BACKGROUND AND PURPOSE: Approximately 30% of strokes are cryptogenic despite an exhaustive in-hospital work-up. Analysis of clot composition following endovascular treatment could provide insight into stroke etiology. T-cells already have been shown to be a major component of vulnerable atherosclerotic carotid lesions. We therefore hypothesize that T-cell content in intracranial thrombi may also be a biomarker of atherothrombotic origin. MATERIALS AND METHODS: We histopathologically investigated 54 consecutive thrombi retrieved after mechanical thrombectomy in acute stroke patients...
2016: PloS One
Christian A Taschner, René Chapot, Vincent Costalat, Paolo Machi, Patrick Courthéoux, Xavier Barreau, Jérôme Berge, Laurent Pierot, Kryzsztof Kadziolka, Betty Jean, Raphaël Blanc, Alessandra Biondi, Hervé Brunel, Sophie Gallas, Ansgar Berlis, Denis Herbreteau, Joachim Berkefeld, Horst Urbach, Samer El Shikh, Jens Fiehler, Hubert Desal, Erika Graf, Alain Bonafé
INTRODUCTION: Hybrid hydrogel-platinum coils (HydroCoil) have proven effective for endovascular aneurysm treatment. To overcome technical limitations (coil stiffness, time restriction for placement), a second generation of softer hydrogel coils has been brought to clinical practice (HydroSoft, HydroFrame). We report on procedural safety and core-lab-assessed angiographic results from an open-label multicenter randomized controlled trial. METHODS: Web-based randomization occurred in 15 medical centers in France and seven in Germany between coil embolization with second-generation hydrogel coils and treatment with any bare platinum coil...
August 2016: Neuroradiology
Machi Tsukamoto, Noriaki Manabe, Tomoari Kamada, Toshihiro Hirai, Jiro Hata, Ken Haruma, Kazuhiko Inoue
Dysphagia is a symptom suggestive of severe underlying pathology, although its causes include organic and non-organic disorders. The epidemiology of dysphagia is, however, poorly understood. We evaluated the prevalence of dysphagia in outpatients in Japan, measured the proportion ultimately found to have an organic cause, and recorded the nature of their symptoms and the underlying disorder. Of 5362 consecutive outpatients attending the Digestive Center at our hospital between June 1, 2010 and December 31, 2012, 186 patients (3...
August 2016: Dysphagia
Machi Suka, Takashi Yamauchi, Hiroki Sugimori
BACKGROUND: Failure and delay in initial treatment contact for mental disorders has been recognized as an important public health problem. According to the concept of mental health literacy, recognition of symptoms is crucial to making decisions to seek or not seek professional help. The aims of this study were to investigate the types of health problems for which Japanese adults intend to seek help, their preferred sources of help, and the factors associated with help-seeking intentions...
2016: BMC Public Health
Naoko Komura, Kenichi G N Suzuki, Hiromune Ando, Miku Konishi, Machi Koikeda, Akihiro Imamura, Rahul Chadda, Takahiro K Fujiwara, Hisae Tsuboi, Ren Sheng, Wonhwa Cho, Koichi Furukawa, Keiko Furukawa, Yoshio Yamauchi, Hideharu Ishida, Akihiro Kusumi, Makoto Kiso
Gangliosides, glycosphingolipids containing one or more sialic acid(s) in the glyco-chain, are involved in various important physiological and pathological processes in the plasma membrane. However, their exact functions are poorly understood, primarily because of the scarcity of suitable fluorescent ganglioside analogs. Here, we developed methods for systematically synthesizing analogs that behave like their native counterparts in regard to partitioning into raft-related membrane domains or preparations. Single-fluorescent-molecule imaging in the live-cell plasma membrane revealed the clear but transient colocalization and codiffusion of fluorescent ganglioside analogs with a fluorescently labeled glycosylphosphatidylinisotol (GPI)-anchored protein, human CD59, with lifetimes of 12 ms for CD59 monomers, 40 ms for CD59's transient homodimer rafts in quiescent cells, and 48 ms for engaged-CD59-cluster rafts, in cholesterol- and GPI-anchoring-dependent manners...
June 2016: Nature Chemical Biology
Jacqueline Freire Machi, Danielle da Silva Dias, Sarah Cristina Freitas, Oscar Albuquerque de Moraes, Maikon Barbosa da Silva, Paula Lázara Cruz, Cristiano Mostarda, Vera M C Salemi, Mariana Morris, Kátia De Angelis, Maria-Cláudia Irigoyen
OBJECTIVE: The aim of this study was to evaluate the effects of aging on metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters after ovarian hormone deprivation (OVX). METHODS: Female Wistar rats (3 or 22 months old) were divided into: young controls, young ovariectomized, old controls, and old ovariectomized (bilateral ovaries removal). After a 9-week follow-up, physical capacity, metabolic parameters, and morphometric and cardiac functions were assessed...
2016: Clinical Interventions in Aging
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