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https://www.readbyqxmd.com/read/28912385/-primary-fracture-prevention-through-the-osteoporosis-liaison-service
#1
Shinichi Nakatoh
It is difficult to prevent primary fragility fractures because the subjects have not yet experienced a fracture. The offers of the community Osteoporosis Liaison Service are important for primary prevention of fragility fractures. The prevention, education, enlightenment, and the offer of osteoporosis examinations are included in this service. It is necessary to deliver the prevention services and osteoporosis education according to the age of the subjects. Hence, for young people, it is effective to include in school education that getting high peak bone mass is important, and for the middle-aged population, it is necessary to include education on the maintenance of bone quantity and the impact on risk factors such as smoking and excessive alcohol consumption...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28878683/association-between-diastolic-dysfunction-with-inflammation-and-oxidative-stress-in-females-ob-ob-mice
#2
Michelle Sartori, Filipe F Conti, Danielle da Silva Dias, Fernando Dos Santos, Jacqueline F Machi, Zaira Palomino, Dulce E Casarini, Bruno Rodrigues, Kátia De Angelis, Maria-Claudia Irigoyen
Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28870626/immunoreactivity-of-urate-transporters-glut9-and-urat1-is-located-in-epithelial-cells-of-the-choroid-plexus-of-human-brains
#3
Naoya Uemura, Ryuta Murakami, Yoichi Chiba, Ken Yanase, Ryuji Fujihara, Masato Mashima, Koichi Matsumoto, Machi Kawauchi, Gotaro Shirakami, Masaki Ueno
It has been suggested that urate plays a protective role in neurons, while hyperuricemia is correlated with atherosclerosis and cardiovascular disease. However, whether there is a system that directly transports urate into the brain remains to be clarified. In this study, the localization of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1), which are known to be representative reabsorptive urate transporters, was immunohistochemically examined in autopsied human brains. Immunoreactivity of GLUT9 was observed on the apical side of the cytoplasm of epithelial cells in the choroid plexus and in the cilia of ependymal cells of the human brain...
September 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28866099/nicotine-transport-in-lung-and-non-lung-epithelial-cells
#4
Mikihisa Takano, Hidetaka Kamei, Machi Nagahiro, Masashi Kawami, Ryoko Yumoto
AIMS: Nicotine is rapidly absorbed from the lung alveoli into systemic circulation during cigarette smoking. However, mechanism underlying nicotine transport in alveolar epithelial cells is not well understood to date. In the present study, we characterized nicotine uptake in lung epithelial cell lines A549 and NCI-H441 and in non-lung epithelial cell lines HepG2 and MCF-7. MATERIALS AND METHODS: Characteristics of [(3)H]nicotine uptake was studied using these cell lines...
August 30, 2017: Life Sciences
https://www.readbyqxmd.com/read/28796617/segmentation-of-3d-high-frequency-ultrasound-images-of-human-lymph-nodes-using-graph-cut-with-energy-functional-adapted-to-local-intensity-distribution
#5
Jen-Wei Kuo, Jonathan Mamou, Yao Wang, Emi Saegusa-Beecroft, Junji Machi, Ernest J Feleppa
Previous studies by our group have shown that three-dimensional high-frequency quantitative ultrasound methods have the potential to differentiate metastatic lymph nodes from cancer-free lymph nodes dissected from human cancer patients. To successfully perform these methods inside the lymph node parenchyma, an automatic segmentation method is highly desired to exclude the surrounding thin layer of fat from quantitative ultrasound processing and accurately correct for ultrasound attenuation. In high-frequency ultrasound images of lymph nodes, the intensity distribution of lymph node parenchyma and fat varies spatially because of acoustic attenuation and focusing effects...
August 9, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28723305/prevalence-of-primary-aldosteronism-without-hypertension-in-the-general-population-results-in-shika-study
#6
Shigehiro Karashima, Mitsuhiro Kometani, Hiromasa Tsujiguchi, Hiroki Asakura, Shigeru Nakano, Mikiya Usukura, Shunsuke Mori, Masashi Ohe, Toshitaka Sawamura, Rika Okuda, Akinori Hara, Toshinari Takamura, Masakazu Yamagishi, Hiroyuki Nakamura, Yoshiyu Takeda, Takashi Yoneda
OBJECTIVE: Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensive patients. However, few data exist regarding the prevalence of PA in the general population. Therefore, we examined the prevalence of PA in the general population including normotensive subjects. METHODS: Plasma renin activity (ng/mL/hr), plasma aldosterone concentration (pg/mL) and aldosterone renin ratio (ARR) were determined in 309 subjects aged >40 years in Horimatsu and Higashi-Matsuho district, Shika-machi, Ishikawa, Japan...
July 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28674310/distribution-of-rotavirus-genotypes-from-the-2008-2009-to-2015-2016-season-in-nara-prefecture-japan
#7
Daichi Sugimoto, Mamoru Nakano, Machi Inada, Misako Fujitani, Shoko Chiba, Takeshi Sakai
This study was conducted to investigate the distribution of rotavirus genotypes in Nara Prefecture, Japan before and after introduction of vaccination in 2011. Since the 2011/2012 season, DS-1-like G1P[8] strains have been detected in Nara Prefecture, accounting for about half of all strains in the 2014/2015 season. During the 2015/2016 season, no DS-1-like G1P[8] strain was detected. G2P[4] was the predominant genotype. Group A rotavirus (RVA), a major cause of severe gastroenteritis in infants and young children, poses an important public health issue in Japan...
July 1, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28652818/adaptation-of-the-european-commission-recommended-user-testing-method-to-patient-medication-information-leaflets-in-japan
#8
Michiko Yamamoto, Hirohisa Doi, Ken Yamamoto, Kazuhiro Watanabe, Tsugumichi Sato, Machi Suka, Takeo Nakayama, Hiroki Sugimori
BACKGROUND: The safe use of drugs relies on providing accurate drug information to patients. In Japan, patient leaflets called Drug Guide for Patients are officially available; however, their utility has never been verified. This is the first attempt to improve Drug Guide for Patients via user testing in Japan. PURPOSE: To test and improve communication of drug information to minimize risk for patients via user testing of the current and revised versions of Drug Guide for Patients, and to demonstrate that this method is effective for improving Drug Guide for Patients in Japan...
2017: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/28642775/ectopic-expression-of-the-grape-hyacinth-muscari-armeniacum-r2r3-myb-transcription-factor-gene-maan2-induces-anthocyanin-accumulation-in-tobacco
#9
Kaili Chen, Hongli Liu, Qian Lou, Yali Liu
Anthocyanins are responsible for the different colors of ornamental plants. Grape hyacinth (Muscari armeniacum), a monocot plant with bulbous flowers, is popular for its fascinating blue color. In the present study, we functionally characterized an R2R3-MYB transcription factor gene MaAN2 from M. armeniacum. Our results indicated that MaAN2 participates in controlling anthocyanin biosynthesis. Sequence alignment and phylogenetic analysis suggested that MaAN2 belonged to the R2R3-MYB family AN2 subgroup. The anthocyanin accumulation of grape hyacinth flowers was positively correlated with the expression of MaAN2...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28599481/prognostic-impact-of-carbohydrate-sulfotransferase-15-in-patients-with-pancreatic-ductal-adenocarcinoma
#10
Zensho Ito, Kazuki Takakura, Machi Suka, Tomoya Kanai, Ryota Saito, Shuichi Fujioka, Mikio Kajihara, Hiroyuki Yanagisawa, Takeyuki Misawa, Tadashi Akiba, Shigeo Koido, Toshifumi Ohkusa
Patients with pancreatic ductal adenocarcinoma (PDA) typically succumb to mortality early, even following surgical resection. Therefore, prognostic factors associated with early mortality are required to improve the survival of patients with PDA following surgical resection. Carbohydrate sulfotransferase 15 (CHST15) is responsible for the biosynthesis of sulfated chondroitin sulfate E (CS-E), which serves a pivotal function in cancer progression by cleaving CD44. CHST15 and CD44 expression in PDA tissue were assessed as a prognostic factor in patients with PDA following surgical resection...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28448112/real-time-imaging-of-2d-and-3d-temperature-distribution-coating-of-metal-ion-intercalated-organic-layered-composites-with-tunable-stimuli-responsive-properties
#11
Machi Takeuchi, Hiroaki Imai, Yuya Oaki
Organic layered materials have intercalation and dynamic properties. The dynamic properties are tuned by the intercalation of the guests. In general, however, it is not easy to achieve the homogeneous and thin coating of the layered materials on substrates with complex shapes because of the two-dimensional anisotropic structures. In the present work, the layered organic composites were homogeneously coated on a variety of substrates for application to practical devices. The metal-ion-intercalated layered polydiacetylene (PDA-M(n+)) with tunable stimuli-responsive color-change properties was coated on substrates, such as paper and cotton consisting of cellulose fibers...
May 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28432895/predictive-ability-of-visit-to-visit-variability-in-hba1c-and-systolic-blood-pressure-for-the-development-of-microalbuminuria-and-retinopathy-in-people-with-type-2-diabetes
#12
Toshiko Takao, Machi Suka, Hiroyuki Yanagisawa, Yutaka Matsuyama, Yasuhiko Iwamoto
AIMS: We explored whether visit-to-visit variability in both glycated hemoglobin (HbA1c) and systolic blood pressure (SBP) simultaneously predicted the development of microalbuminuria and retinopathy, and whether the predictive ability of these measurements changed according to mean HbA1c and SBP levels in people with type 2 diabetes. METHODS: A retrospective observational cohort study was conducted on 243 type 2 diabetes patients with normoalbuminuria and 486 without retinopathy at the first visit and within 1year thereafter...
April 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28428925/medical-school-hotline-hawai-i-medical-education-program-an-innovative-method-to-incorporate-american-education-methodologies-into-the-traditional-japanese-system
#13
Junji Machi, Emi Saegusa-Beecroft, Satoru Izutsu, Jerris R Hedges
No abstract text is available yet for this article.
April 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28412842/four-new-sesquiterpenoids-from-sphaeranthus-indicus
#14
Lakshma Reddy Emani, Suryachandra Rao Ravada, Machi Raju Garaga, Bharani Meka, Trimurtulu Golakoti
Isolation and characterisation of two new eudesmanolides, 5α-hydroperoxy-7α-hydroxy-isosphaerantholide (1) and (11α,13-dihydro-7α-hydroxyfrullanolide-13-yl)-adenine (2) from the flower heads of Sphaeranthus indicus are described. In addition, 5α-hydroxy-isosphaerantholide (3) and 11α,13-dihydro-eudesman-3,5,7-triene-6α-12-olide (4) are reported first time as a metabolite of S. indicus and as a natural product, respectively. The structures of these compounds were established from rigorous analysis of their high-resolution mass, IR, UV, (1)H NMR, (13)C NMR and 2D NMR spectral data...
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28302124/reliability-and-acceptability-of-six-station-multiple-mini-interviews-past-behavioural-versus-situational-questions-in-postgraduate-medical-admission
#15
Toru Yamada, Juichi Sato, Hiroshi Yoshimura, Tomoya Okubo, Eiji Hiraoka, Takashi Shiga, Tadao Kubota, Shigeki Fujitani, Junji Machi, Nobutaro Ban
BACKGROUND: The multiple mini-interview (MMI) is increasingly used for postgraduate medical admissions and in undergraduate settings. MMIs use mostly Situational Questions (SQs) rather than Past-Behavioural Questions (PBQs). A previous study of MMIs in this setting, where PBQs and SQs were asked in the same order, reported that the reliability of PBQs was non-inferior to SQs and that SQs were more acceptable to candidates. The order in which the questions are asked may affect reliability and acceptability of an MMI...
March 16, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28277288/ct-imaging-selection-in-acute-stroke
#16
Laurie Bouchez, Roman Sztajzel, Maria Isabel Vargas, Paolo Machi, Zsolt Kulcsar, Pierre-Alexandre Poletti, Vitor Mendes Pereira, Karl-Olof Lövblad
Acute stroke has become an increasingly treatable cause of acute neurological deficits. Indeed, over the last two decades, the introduction of first thrombolysis, and now thrombectomy has improved patient outcomes and extended the therapeutic window. Computed tomography has been established as the most simple and readily available technique for the diagnosis and management of patients with acute stroke. Indeed, CT allows easy confirmation or exclusion of acute hemorrhage on the one hand, and on the other hand the early signs are quite reliable in the detection of ischemia...
October 26, 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/28113305/local-transverse-slice-based-level-set-method-for-segmentation-of-3-d-high-frequency-ultrasonic-backscatter-from-dissected-human-lymph-nodes
#17
Thanh Minh Bui, Alain Coron, Jonathan Mamou, Emi Saegusa-Beecroft, Tadashi Yamaguchi, Eugene Yanagihara, Junji Machi, S Lori Bridal, Ernest Joseph Feleppa
OBJECTIVE: To detect metastases in freshly excised human lymph nodes (LNs) using three-dimensional (3-D), high-frequency, quantitative ultrasound (QUS) methods, the LN parenchyma (LNP) must be segmented to preclude QUS analysis of data in regions outside the LNP and to compensate ultrasound attenuation effects due to overlying layers of LNP and residual perinodal fat (PNF). METHODS: After restoring the saturated radio-frequency signals from PNF using an approach based on smoothing cubic splines, the three regions, i...
July 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27978599/impact-of-postprandial-hyperglycemia-at-clinic-visits-on-the-incidence-of-cardiovascular-events-and-all-cause-mortality-in-patients-with-type-2-diabetes
#18
Toshiko Takao, Machi Suka, Hiroyuki Yanagisawa, Yasuhiko Iwamoto
AIMS/INTRODUCTION: We evaluated the impact of postprandial hyperglycemia at clinic visits on the incidence of cardiovascular diseases (CVD) and all-cause mortality independently of mean glycosylated hemoglobin in type 2 diabetes patients in a real-world setting. MATERIALS AND METHODS: The present retrospective observational cohort study included 646 type 2 diabetes patients. All of the participants had their initial consultations at the Institute for Diabetes Care and Research, Asahi Life Foundation affiliated Marunouchi Hospital, Tokyo, Japan, during the period from 1995 to 1996, visited the clinic ≥4 times, had their 2-h post-breakfast blood glucose (2h-PBBG) levels measured and were followed up for ≥1 year...
July 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27899627/improvements-to-patric-the-all-bacterial-bioinformatics-database-and-analysis-resource-center
#19
Alice R Wattam, James J Davis, Rida Assaf, Sébastien Boisvert, Thomas Brettin, Christopher Bun, Neal Conrad, Emily M Dietrich, Terry Disz, Joseph L Gabbard, Svetlana Gerdes, Christopher S Henry, Ronald W Kenyon, Dustin Machi, Chunhong Mao, Eric K Nordberg, Gary J Olsen, Daniel E Murphy-Olson, Robert Olson, Ross Overbeek, Bruce Parrello, Gordon D Pusch, Maulik Shukla, Veronika Vonstein, Andrew Warren, Fangfang Xia, Hyunseung Yoo, Rick L Stevens
The Pathosystems Resource Integration Center (PATRIC) is the bacterial Bioinformatics Resource Center (https://www.patricbrc.org). Recent changes to PATRIC include a redesign of the web interface and some new services that provide users with a platform that takes them from raw reads to an integrated analysis experience. The redesigned interface allows researchers direct access to tools and data, and the emphasis has changed to user-created genome-groups, with detailed summaries and views of the data that researchers have selected...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27884859/isolated-gnrh-deficiency-genotypic-and-phenotypic-characteristics-of-the-genetically-heterogeneous-greek-population
#20
LETTER
M I Stamou, P Varnavas, M Kentrou, F Adamidou, A Voutetakis, J Jing, L Plummer, V Koika, N A Georgopoulos
No abstract text is available yet for this article.
March 2017: European Journal of Endocrinology
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