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Akihiko Kimura, Yuko Ishida, Machi Furuta, Mizuho Nosaka, Yumi Kuninaka, Akira Taruya, Naofumi Mukaida, Toshikazu Kondo
BACKGROUND: A clear understanding of the molecular mechanisms underlying hemodynamic stress-initiated cardiac hypertrophy is important for preventing heart failure. Interferon-γ (IFN-γ) has been suggested to play crucial roles in various diseases other than immunological disorders by modulating the expression of myriad genes. However, the involvement of IFN-γ in the pathogenesis of cardiac hypertrophy still remains unclear. METHODS AND RESULTS: In order to elucidate the roles of IFN-γ in pressure overload-induced cardiac pathology, we subjected Balb/c wild-type (WT) or IFN-γ-deficient ( Ifng -/- ) mice to transverse aortic constriction (TAC)...
March 19, 2018: Journal of the American Heart Association
Marco Antonio F Carneiro, Beatriz da C A Alves, Flávia de Sousa Gehrke, José Nuno Domingues, Nelson Sá, Susana Paixão, João Figueiredo, Ana Ferreira, Cleonice Almeida, Amaury Machi, Eriane Savóia, Vânia Nascimento, Fernando Fonseca
INTRODUCTION: Global climate changes directly affect the natural environment and contribute to an increase in the transmission of diseases by vectors. Among these diseases, dengue is at the top of the list. The aim of our study was to understand the consequences of temporal variability of air temperature in the occurrence of dengue in an area comprising seven municipalities of the Greater São Paulo. METHOD: Characterization of a temporal trend of the disease in the region between 2010 and 2013 was performed through analysis of the notified number of dengue cases over this period...
November 2017: Revista da Associação Médica Brasileira
Takashi Suzuki, Ryota Inokuchi, Kazuo Hanaoka, Machi Suka, Hiroyuki Yanagisawa
Objectives: Minimally invasive epiduroscopy has recently been reported as an effective treatment procedure for chronic and intractable low back pain. However, no study has determined safe anesthetics for monitored anesthesia care during epiduroscopy. We aimed to compare and evaluate conventional monitored anesthesia care drugs with dexmedetomidine. Methods: A retrospective study including all patients who underwent epiduroscopy at the JR Tokyo General Hospital from April 2011 to March 2016 was designed...
2018: SAGE Open Medicine
Christian A Taschner, René Chapot, Vincent Costalat, Paolo Machi, Patrick Courthéoux, Xavier Barreau, Jérôme Berge, Laurent Pierot, Krzysztof Kadziolka, Betty Jean, Raphaël Blanc, Alessandra Biondi, Hervé Brunel, Sophie Gallas, Ansgar Berlis, Denis Herbreteau, Joachim Berkefeld, Horst Urbach, Samer Elsheikh, Jens Fiehler, Hubert Desal, Erika Graf, Alain Bonafé
BACKGROUND AND PURPOSE: Endovascular embolization of intracranial aneurysms with hydrogel-coated coils lowers the risk of major recurrence, but technical limitations (coil stiffness and time restriction for placement) have prevented their wider clinical use. We aimed to assess the efficacy of softer, second-generation hydrogel coils. METHODS: A randomized controlled trial was conducted at 22 centers in France and Germany. Patients aged 18 to 75 years with untreated ruptured or unruptured intracranial aneurysms measuring 4 to 12 mm in diameter were eligible and randomized (1:1 using a web-based system, stratified by rupture status) to coiling with either second-generation hydrogel coils or bare platinum coils...
March 2018: Stroke; a Journal of Cerebral Circulation
Zsolt Kulcsár, Paolo Machi, Karl Schaller, Karl Olof Lovblad, Philippe Bijlenga
Treatment of ruptured deep-seated arteriovenous malformations is challenging and associated with elevated risks. This is due to the proximity or involvement of critical brain structures and the specifically fine and delicate angioarchitecture of these lesions, making both endovascular and surgical access technically complicated. We present the advantages of a true combined, open surgical and endovascular transvenous approach in a hybrid operating room. The technique may overcome in part the difficulties and may improve safety and risk related concerns...
February 1, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
Jeremy Hofmeister, Zsolt Kulcsar, Gianmarco Bernava, Alain Pellaton, Hasan Yilmaz, Gorislav Erceg, Maria Isabel Vargas, Karl-Olof Lovblad, Paolo Machi
OBJECTIVE: Mechanical thrombectomy (MTB) is a treatment of reference for acute ischemic stroke due to large brain vessel occlusion but some concerns remain about its use in small distal branches. In the present study, we assessed the efficacy and the safety of distal MTB using the Catch Mini (CM) stent retriever. METHODS: We retrospectively reviewed a prospectively maintained database of all consecutive patients who underwent MTB for a distal intracranial occlusion with the Catch Mini device at our hospital...
February 1, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
Machi Atarashi, Takeshi Izawa, Rena Miyagi, Shoko Ohji, Ai Hashimoto, Mitsuru Kuwamura, Jyoji Yamate
Nonalcoholic fatty liver disease (NAFLD) is now the most common liver disease in the world. NAFLD can progress to nonalcoholic steatohepatitis (NASH), cirrhosis and eventually hepatocellular carcinoma. Acquired hepatic iron overload is seen in a number of patients with NAFLD; however, its significance in the pathology of NAFLD is still debated. Here, we investigated the role of dietary iron supplementation in experimental steatohepatitis in rats. Rats were fed a control, high-fat (HF), high-fat high-iron (HFHI) and high-iron (HI) diet for 30 weeks...
February 4, 2018: Nutrients
Daniel Mantilla, Marine Le Corre, Federico Cagnazzo, Gregory Gascou, Omer Eker, Paolo Machi, Carlos Riquelme, Cyril Dargazanli, Vincent Costalat, Alain Bonafe, Pierre-Henri Lefevre
BACKGROUND AND PURPOSE: Transarterial Onyx embolization is an effective treatment for patients with intracranial dural arteriovenous fistula (DAVF). A study was performed to determine whether the clinical and radiological outcomes after transarterial Onyx treatment were affected by the type of cortical venous drainage (direct vs indirect) of high-grade DAVF. MATERIALS AND METHODS: Between May 2006 and December 2014, demographic data, clinical presentation, angiographic characteristics, and treatment-related outcomes were collected for 54 patients divided into two groups (intracranial DAVF with direct and indirect cortical venous drainage)...
January 30, 2018: Journal of Neurointerventional Surgery
Takashi Yamauchi, Takeshi Sasaki, Toru Yoshikawa, Shun Matsumoto, Masaya Takahashi, Machi Suka, Hiroyuki Yanagisawa
OBJECTIVE: This study aimed to clarify whether work-related adverse events in cases involving compensation for mental disorders and suicide differ by sex and industry using a database containing all relevant cases reported from 2010 to 2014 in Japan. METHODS: A total of 1,362 eligible cases involving compensation for mental disorders (422 females and 940 males) were analyzed. RESULTS: Among males, 55.7% of cases were attributed to "long working hours...
January 24, 2018: Journal of Occupational and Environmental Medicine
Alice R Wattam, Thomas Brettin, James J Davis, Svetlana Gerdes, Ronald Kenyon, Dustin Machi, Chunhong Mao, Robert Olson, Ross Overbeek, Gordon D Pusch, Maulik P Shukla, Rick Stevens, Veronika Vonstein, Andrew Warren, Fangfang Xia, Hyunseung Yoo
In the "big data" era, research biologists are faced with analyzing new types that usually require some level of computational expertise. A number of programs and pipelines exist, but acquiring the expertise to run them, and then understanding the output can be a challenge.The Pathosystems Resource Integration Center (PATRIC, ) has created an end-to-end analysis platform that allows researchers to take their raw reads, assemble a genome, annotate it, and then use a suite of user-friendly tools to compare it to any public data that is available in the repository...
2018: Methods in Molecular Biology
Paolo Machi, Rafik Ouared, Olivier Brina, Pierre Bouillot, Hasan Yilmaz, Maria I Vargas, Renato Gondar, Philippe Bijlenga, Karl O Lovblad, Zsolt Kulcsár
BACKGROUND AND PURPOSE: Hemodynamics play a driving role in the life cycle of brain aneurysms from initiation through growth until eventual rupture. The specific factors behind aneurysm growth, especially in small aneurysms, are not well elucidated. The goal of this study was to differentiate focal versus general growth and to analyze the hemodynamic microenvironment at the sites of enlargement in small cerebral aneurysms. MATERIALS AND METHODS: Small aneurysms showing growth during follow-up were identified from our prospective aneurysm database...
December 5, 2017: Clinical Neuroradiology
Christina Iosif, Michel Piotin, Suzana Saleme, Xavier Barreau, Jacques Sedat, Yves Chau, Nader Sourour, Mohamed Aggour, Herve Brunel, Alain Bonafe, Paolo Machi, Carlos Riquelme, Vincent Costalat, Laurent Pierot, Raphael Blanc, Charbel Mounayer
BACKGROUND AND PURPOSE: To evaluate the safety and effectiveness of the low-profile braided intracranial stents called the Low Profile Visualized Intraluminal Support (LVIS) devices for stent-assisted coil embolization of wide-necked intracranial aneurysms. MATERIALS AND METHODS: This was a prospective, multicenter, observational study of unruptured and ruptured intracranial aneurysms treated with the LVIS devices. Imaging and clinical data were independently analyzed respectively by CoreLab and Clinical Event Committee...
November 24, 2017: Journal of Neurointerventional Surgery
Machi Suka, Takashi Yamauchi, Hiroyuki Yanagisawa
BACKGROUND: Communicating health messages is an important way to influence people's behaviors towards health issues. Providers need to incorporate audience's perspective to design more persuasive messages. This study aimed to develop rating scales for measuring audience's perception of effectiveness of health messages in Japanese people. METHODS: The comprehensibility scale including five items and the persuasiveness scale including seven items were designed based on literature review...
September 29, 2017: Environmental Health and Preventive Medicine
Emily P Ernest, Anthony S Machi, Brock A Karolcik, Paul R LaSala, Matthew J Dietz
Adjuvant treatments including Betadine, Dakin's solution (sodium hypochlorite), or hydrogen peroxide (H2 O2 ) have been attempted to eradicate prosthetic joint infection caused by biofilm or intracellular bacteria. The purpose of this study was to evaluate the in vitro abilities of chemical adjuvants to decrease Staphylococcus aureus (S. aureus) biofilm presence on orthopaedic implant grade materials, including titanium, stainless steel, and cobalt chrome. S. aureus biofilms were grown for 48 h and evaluated for baseline colony forming units/centimeter squared (CFU/cm2 ) and compared to treatments with Betadine, Dakin's solution, H2 O2 , or 1% chlorine dioxide (ClO2 )...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
O F Eker, P Panni, C Dargazanli, G Marnat, C Arquizan, P Machi, I Mourand, G Gascou, E Le Bars, V Costalat, A Bonafé
BACKGROUND AND PURPOSE: Mechanical thrombectomy for patients with acute ischemic stroke with tandem occlusions has been shown to present varying reperfusion successes and clinical outcomes. However, the heterogeneity of tandem occlusion etiology has been strongly neglected in previous studies. We retrospectively investigated patients with acute ischemic stroke atherothrombotic tandem occlusion. MATERIALS AND METHODS: All consecutive patients with acute ischemic stroke with atherothrombotic tandem occlusions treated with mechanical thrombectomy in our center between September 2009 and April 2015 were analyzed...
November 2017: AJNR. American Journal of Neuroradiology
Fei Ai, Jianqiang Qian, Junfeng Shi, Machi Zhang
The transmission properties of beams in gain fibers are studied with the complex refractive index beam propagation method (CRI-BPM). The method is checked by comparison with an analytic method. The behavior of a gain-guided, index antiguided (GG-IAG) fiber with different gain coefficients is studied. The simulation results show that the signal can transfer in the fiber with almost no loss when the gain coefficient reaches the threshold of the fundamental mode, and the shape of output spot will have no major changes when the gain coefficient is over the thresholds of high-order modes, even when the mode competition is not obvious...
October 10, 2017: Applied Optics
Takashi Yamauchi, Toru Yoshikawa, Takeshi Sasaki, Shun Matsumoto, Masaya Takahashi, Machi Suka, Hiroyuki Yanagisawa
In Japan, overwork-related disorders occur among local public employees as well as those in private businesses. However, to date, there are no studies reporting the state of compensation for cerebrovascular/cardiovascular diseases (CCVD) and mental disorders due to overwork or work-related stress among local public employees in Japan over multiple years. This report examined the recent trend of overwork-related CCVD and mental disorders, including the incidence rates of these disorders, among local public employees in Japan from the perspective of compensation for public accidents, using data from the Japanese Government and relevant organizations...
October 11, 2017: Industrial Health
Dionysios A Antonopoulos, Rida Assaf, Ramy Karam Aziz, Thomas Brettin, Christopher Bun, Neal Conrad, James J Davis, Emily M Dietrich, Terry Disz, Svetlana Gerdes, Ronald W Kenyon, Dustin Machi, Chunhong Mao, Daniel E Murphy-Olson, Eric K Nordberg, Gary J Olsen, Robert Olson, Ross Overbeek, Bruce Parrello, Gordon D Pusch, John Santerre, Maulik Shukla, Rick L Stevens, Margo VanOeffelen, Veronika Vonstein, Andrew S Warren, Alice R Wattam, Fangfang Xia, Hyunseung Yoo
The Pathosystems Resource Integration Center (PATRIC, is designed to provide researchers with the tools and services that they need to perform genomic and other 'omic' data analyses. In response to mounting concern over antimicrobial resistance (AMR), the PATRIC team has been developing new tools that help researchers understand AMR and its genetic determinants. To support comparative analyses, we have added AMR phenotype data to over 15 000 genomes in the PATRIC database, often assembling genomes from reads in public archives and collecting their associated AMR panel data from the literature to augment the collection...
July 31, 2017: Briefings in Bioinformatics
Shinichi Nakatoh
It is difficult to prevent primary fragility fractures because the subjects have not yet experienced a fracture. The offers of the community Osteoporosis Liaison Service are important for primary prevention of fragility fractures. The prevention, education, enlightenment, and the offer of osteoporosis examinations are included in this service. It is necessary to deliver the prevention services and osteoporosis education according to the age of the subjects. Hence, for young people, it is effective to include in school education that getting high peak bone mass is important, and for the middle-aged population, it is necessary to include education on the maintenance of bone quantity and the impact on risk factors such as smoking and excessive alcohol consumption...
2017: Clinical Calcium
Michelle Sartori, Filipe F Conti, Danielle da Silva Dias, Fernando Dos Santos, Jacqueline F Machi, Zaira Palomino, Dulce E Casarini, Bruno Rodrigues, Kátia De Angelis, Maria-Claudia Irigoyen
Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index...
2017: Frontiers in Physiology
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