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Rapid-sequence induction

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https://www.readbyqxmd.com/read/28989091/more-than-just-antibodies-protective-mechanisms-of-a-mucosal-vaccine-against-fish-pathogen-flavobacterium-columnare
#1
Dongdong Zhang, Wilawan Thongda, Chao Li, Honggang Zhao, Benjamin H Beck, Haitham Mohammed, Covadonga R Arias, Eric Peatman
A recently developed attenuated vaccine for Flavobacterium columnare has been demonstrated to provide superior protection for channel catfish, Ictalurus punctatus, against genetically diverse columnaris isolates. We were interested in examining the mechanisms of this protection by comparing transcriptional responses to F. columnare challenge in vaccinated and unvaccinated juvenile catfish. Accordingly, 58 day old fingerling catfish (28 days post-vaccination or unvaccinated control) were challenged with a highly virulent F...
October 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28975884/anaesthesia-in-patients-undergoing-esophago-gastro-duodenoscopy-for-suspected-bleeding
#2
Ida Helsø, Martin Risom, Therese Risom Vestergaard, Nicolai Bang Foss, Steffen Rosenstock, Morten Hylander Møller, Lars Hyldborg Lundstrøm, Nicolai Lohse
INTRODUCTION: Upper gastrointestinal bleeding (UGIB) is a common emergency. Currently, there are no agreed guidelines on the level of anaesthetic support required in patients undergoing acute esophago-gastro-duodendoscopy (EGD). METHODS: An online questionnaire comprising 19 questions was distributed to all members of the Danish Association of Anaesthesiology and Intensive Care (n = 1,418) and the Danish Society of Anaesthesiologists in Training (n = 566). The questions concerned clinical practice for anaesthesia care to patients undergoing EGD for suspected UGIB and availability of local guidelines...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28969793/activation-of-zmmkk10-a-maize-mitogen-activated-protein-kinase-kinase-induces-ethylene-dependent-cell-death
#3
Ying Chang, Hailian Yang, Dongtao Ren, Yuan Li
Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant growth, development and stress responses. Here, we report that ZmMKK10, a maize MAP kinase kinase, positively regulates cell death. Sequence comparison to Arabidopsis MKKs has led to ZmMKK10 being classified as a group D MKK. Kinase activity analysis of recombinant ZmMKK10 showed that the Mg(2+) ion was required for its kinase activity. Transient expression of ZmMKK10(WT) or ZmMKK10(DD) (the active form of ZmMKK10) in maize mesophyll protoplast significantly increased the cell death rate...
November 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28960597/ideal-cricoid-pressure-is-biomechanically-impossible-during-laryngoscopy
#4
Christopher E Trethewy, Steven R Doherty, Julie M Burrows, Don Clausen
STUDY OBJECTIVE: A prospective, randomised controlled trial of Rapid Sequence Intubation (RSI) with Cricoid Pressure (CP) within the Emergency Department (ED). The primary aim of the study was to examine the link between ideal CP and the incidence of aspiration. METHOD: Patients >18 years of age undergoing RSI in the ED of two hospitals in New South Wales, Australia, were randomly assigned to receive Measured CP using weighing scales to target the ideal CP range (3...
September 28, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28956237/usefulness-of-oxygen-reserve-index-ori%C3%A2-a-new-parameter-of-oxygenation-reserve-potential-for-rapid-sequence-induction-of-general-anesthesia
#5
Keisuke Yoshida, Tsuyoshi Isosu, Yoshie Noji, Makiko Hasegawa, Yuzo Iseki, Rieko Oishi, Tsuyoshi Imaizumi, Norie Sanbe, Shinju Obara, Masahiro Murakawa
The oxygen reserve index (ORi™) is a new parameter for monitoring oxygen reserve noninvasively. The aim of this study was to examine the usefulness of ORi for rapid sequence induction (RSI). Twenty adult patients who were scheduled for surgical procedures under general anesthesia were enrolled. After attaching a sensor capable of measuring ORi, oxygen (6 L/min) and fentanyl (2 μg/kg) were administered. After 3 min, propofol 2 mg/kg and rocuronium 1 mg/kg were administered without ventilation. Regardless of changes in ORi, tracheal intubation was performed either 2 min after administration of propofol or when percutaneous oxygen saturation (SpO2) reached 98%...
September 27, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28935878/old-yellow-enzyme-homologues-in-mucor-circinelloides-expression-profile-and-biotransformation
#6
Alice Romagnolo, Federica Spina, Anna Poli, Sara Risso, Bianca Serito, Michele Crotti, Daniela Monti, Elisabetta Brenna, Luisa Lanfranco, Giovanna Cristina Varese
The reduction of C=C double bond, a key reaction in organic synthesis, is mostly achieved by traditional chemical methods. Therefore, the search for enzymes capable of performing this reaction is rapidly increasing. Old Yellow Enzymes (OYEs) are flavin-dependent oxidoreductases, initially isolated from Saccharomyces pastorianus. In this study, the presence and activation of putative OYE enzymes was investigated in the filamentous fungus Mucor circinelloides, which was previously found to mediate C=C reduction...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28913501/acute-poisoning-due-to-ingestion-of-datura-stramonium-a-case-report
#7
Sebastian Daniel Trancă, Robert Szabo, Mihaela Cociş
Datura stramonium (DS) is a widespread annual plant, containing atropine, hyoscyamine, and scopolamine, which can produce poisoning with a severe anticholinergic syndrome. Teenagers ingest the roots, seeds or the entire plant to obtain its hallucinogenic and euphoric effects. We presented the case of a 22 year old male who was admitted to the Emergency Room in a coma after consuming Datura stramonium, 2 hours earlier. The patient presented with fever, tachycardia with right bundle branch block, and urinary retention...
April 2017: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/28889210/ketamine-and-midazolam-differently-impact-post-intubation-hemodynamic-profile-when-used-as-induction-agents-during-emergency-airway-management-in-hemodynamically-stable-patients-with-st-elevation-myocardial-infarction
#8
Marco Zuin, Gianluca Rigatelli, Fabio Dell'Avvocata, Giuseppe Faggian, Luca Conte, Sara Giatti, Flavio Michielan, Loris Roncon
We investigated the incidence of post-intubation hypotension (PIH) in hemodynamically stable patients with STEMI requiring rapid sequences intubation (RSI) and medicated with ketamine or midazolam as induction agent. STEMI patients admitted between 1st January 2009 and 1st January 2017 who did not receive any type of inotropic support before the endotracheal intubation (ETI) was reviewed. PIH was defined as a reduction greater than 20% or a drop of systolic blood pressure (SBP) below 90 mmHg within 10 min from the administration of the induction agent [ketamine (1 mg/kg) or midazolam (0...
September 9, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28881083/transcriptome-analysis-using-rna-seq-%C3%A2-of-lomandra-longifolia-roots-infected-with-phytophthora-cinnamomi-reveals-the-complexity-of-the-resistance-response
#9
Md Tohidul Islam, Hashmath Inayath Hussain, James Edward Rookes, David Miles Cahill
The plant pathogen Phytophthora cinnamomi is the causal agent of disease in numerous species, is a major threat to natural vegetation and has economic impacts in agriculture. The pathogen principally invades the root system which, in susceptible species, is rapidly colonised and functionally destroyed. Few species are resistant, however, where resistance is expressed the pathogen is restricted to small, localised lesions. The molecular mechanisms that underpin this response in resistant species are not well understood...
September 7, 2017: Plant Biology
https://www.readbyqxmd.com/read/28867469/tmsr-c-scavenger-receptor-class-c-plays-a-pivotal-role-in-antifungal-and-antibacterial-immunity-in-the-coleopteran-insect-tenebrio-molitor
#10
Soo Gon Kim, Yong Hun Jo, Jeong Hwan Seong, Ki Beom Park, Mi Young Noh, Jun Ho Cho, Hye Jin Ko, Chang Eun Kim, Hamisi Tindwa, Bharat Bhusan Patnaik, In Seok Bang, Yong Seok Lee, Yeon Soo Han
Scavenger receptors (SRs) constitute a family of membrane-bound receptors that bind to multiple ligands. The SR family of proteins is involved in removing cellular debris, oxidized low-density lipoproteins, and pathogens. Specifically, class C scavenger receptors (SR-C) have also been reported to be involved in phagocytosis of gram-positive and -negative bacteria in Drosophila and viruses in shrimp. However, reports are unavailable regarding the role of SR-C in antifungal immune mechanisms in insects. In this study, a full-length Tenebrio molitor SR-C (TmSR-C) sequence was obtained by 5'- and 3'-Rapid amplification of cDNA ends-polymerase chain reaction (RACE-PCR)...
September 1, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28835591/rasd1-is-an-estrogen-responsive-immediate-early-gene-and-modulates-expression-of-late-genes-in-rat-anterior-pituitary-cells
#11
Linghong Wang, Tetsuo Mitsui, Maho Ishida, Michi Izawa, Jun Arita
Dexamethasone-induced Ras-related protein 1 (Rasd1) is a member of the Ras superfamily of monomeric G proteins that have a regulatory function in signal transduction. Here we investigated the role of Rasd1 in regulating estrogen-induced gene expression in primary cultures of rat anterior pituitary cells. Rasd1 mRNA expression in anterior pituitary cells decreased after treatment with forskolin or serum and increased after treatment with 17β-estradiol (E2). Increases in Rasd1 mRNA expression occurred as early as 0...
August 23, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28767072/insights-into-the-mechanisms-involved-in-strong-hemorrhage-and-dermonecrosis-induced-by-atroxlysin-ia-a-pi-class-snake-venom-metalloproteinase
#12
Luciana Aparecida Freitas-de-Sousa, Mônica Colombini, Mônica Lopes-Ferreira, Solange M T Serrano, Ana Maria Moura-da-Silva
Hemorrhage is the most prominent effect of snake venom metalloproteinases (SVMPs) in human envenomation. The capillary injury is a multifactorial effect caused by hydrolysis of the components of the basement membrane (BM). The PI and PIII classes of SVMPs are abundant in viperid venoms and hydrolyze BM components. However, hemorrhage is associated mostly with PIII-class SVMPs that contain non-catalytic domains responsible for the binding of SVMPs to BM proteins, facilitating enzyme accumulation in the tissue and enhancing its catalytic efficiency...
August 2, 2017: Toxins
https://www.readbyqxmd.com/read/28763317/rocuronium-is-more-hepatotoxic-than-succinylcholine-in-vitro
#13
Martin Sauer, Ines Piel, Cristof Haubner, Georg Richter, Miriam Mann, Gabriele Nöldge-Schomburg, Thomas Mencke
BACKGROUND: The development of liver failure is a major problem in critically ill patients. The hepatotoxicity of many drugs, as one important reason for liver failure, is poorly screened for in human models. Rocuronium and succinylcholine are neuromuscular blocking agents used for tracheal intubation and for rapid-sequence induction. OBJECTIVE: We used an in-vitro test with a permanent cell line and compared rocuronium and succinylcholine for hepatotoxicity. DESIGN: In-vitro study...
September 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28759496/addition-of-nasal-cannula-can-either-impair-or-enhance-preoxygenation-with-a-bag-valve-mask-a-randomized-crossover-design-study-comparing-oxygen-flow-rates
#14
David McQuade, Matthew R Miller, Clare Hayes-Bradley
BACKGROUND: A critical safety component of emergency anesthesia is the avoidance of hypoxemia during the apneic phase of a rapid sequence intubation. Preoxygenation with a bag valve mask (BVM) or anesthetic circuit may be improved with supplemental oxygen by nasal cannula (NC) if there is a mask leak. In addition, NC is recommended for apneic oxygenation after induction and may be placed before preoxygenation. However, the optimum NC flow rate for preoxygenation or whether the presence of NC alone creates a mask leak remains unclear...
July 26, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28754704/metagenomic-analysis-of-dairy-bacteriophages-extraction-method-and-pilot-study-on-whey-samples-derived-from-using-undefined-and-defined-mesophilic-starter-cultures
#15
Musemma K Muhammed, Witold Kot, Horst Neve, Jennifer Mahony, Josué L Castro-Mejía, Lukasz Krych, Lars H Hansen, Dennis S Nielsen, Søren J Sørensen, Knut J Heller, Douwe van Sinderen, Finn K Vogensen
Despite being potentially highly useful for characterizing the biodiversity of phages, metagenomic studies are currently not available for dairy bacteriophages, partly due to the lack of a standard procedure for phage extraction. We optimized an extraction method that allows the removal of the bulk protein from whey and milk samples with losses of less than 50% of spiked phages. The protocol was applied to extract phages from whey in order to test the notion that members of Lactococcus lactis 936 (now Sk1virus), P335, c2 (now C2virus) and Leuconostoc phage groups are the most frequently encountered in the dairy environment...
October 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28751801/drought-tolerant-brassica-rapa-shows-rapid-expression-of-gene-networks-for-general-stress-responses-and-programmed-cell-death-under-simulated-drought-stress
#16
Yi Ming Guo, Birgit Samans, Sheng Chen, Kidist B Kibret, Sarah Hatzig, Neil C Turner, Matthew N Nelson, Wallace A Cowling, Rod J Snowdon
Production of oilseed rape/canola (Brassica napus) is increasingly threatened by dry conditions while the demand for vegetable oil is increasing. Brassica rapa is a genetically diverse ancestor of B. napus, and is readily crossed with B. napus. Recently, we reported promising levels of drought tolerance in a wild type of B. rapa which could be a source of drought tolerance for B. napus. We analysed global gene expression by messenger RNA sequencing in seedlings of the drought-tolerant and a drought-sensitive genotype of B...
2017: Plant Molecular Biology Reporter
https://www.readbyqxmd.com/read/28739829/inherent-oxidative-stress-in-the-lewis-rat-is-associated-with-resistance-to-toxoplasmosis
#17
William H Witola, Chi Yong Kim, Xuejin Zhang
The course of Toxoplasma gondii infection in rats closely resembles that in humans. However, compared to the Brown Norway (BN) rat, the Lewis (LEW) rat is extremely resistant to T. gondii infection. Thus, we performed RNA sequencing analysis of the LEW rat versus the BN rat, with or without T. gondii infection, in order to unravel molecular factors directing robust and rapid early T. gondii-killing mechanisms in the LEW rat. We found that compared to the uninfected BN rat, the uninfected LEW rat has inherently higher transcript levels of cytochrome enzymes (Cyp2d3, Cyp2d5, and Cybrd1, which catalyze generation of reactive oxygen species [ROS]), with concomitant higher levels of ROS...
October 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28701342/activating-transcription-factor-3-promotes-loss-of-the-acinar-cell-phenotype-in-response-to-cerulein-induced-pancreatitis-in-mice
#18
Elena N Fazio, Claire C Young, Jelena Toma, Michael Levy, Kurt R Berger, Charis L Johnson, Rashid Mehmood, Patrick Swan, Alphonse Chu, Sean P Cregan, F Jeffrey Dilworth, Christopher J Howlett, Christopher L Pin
Pancreatitis is a debilitating disease of the exocrine pancreas that, under chronic conditions, is a major susceptibility factor for pancreatic ductal adenocarcinoma (PDAC). Although down-regulation of genes that promote the mature acinar cell fate is required to reduce injury associated with pancreatitis, the factors that promote this repression are unknown. Activating transcription factor 3 (ATF3) is a key mediator of the unfolded protein response, a pathway rapidly activated during pancreatic insult. Using chromatin immunoprecipitation followed by next-generation sequencing, we show that ATF3 is bound to the transcriptional regulatory regions of >30% of differentially expressed genes during the initiation of pancreatitis...
September 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28673543/autogenous-control-of-5%C3%A2-top-mrna-stability-by-40s-ribosomes
#19
Antonio Gentilella, Francisco D Morón-Duran, Pedro Fuentes, Guilherme Zweig-Rocha, Ferran Riaño-Canalias, Joffrey Pelletier, Marta Ruiz, Gemma Turón, Julio Castaño, Albert Tauler, Clara Bueno, Pablo Menéndez, Sara C Kozma, George Thomas
Ribosomal protein (RP) expression in higher eukaryotes is regulated translationally through the 5′TOP sequence. This mechanism evolved to more rapidly produce RPs on demand in different tissues. Here we show that 40S ribosomes, in a complex with the mRNA binding protein LARP1, selectively stabilize 5′TOP mRNAs, with disruption of this complex leading to induction of the impaired ribosome biogenesis checkpoint (IRBC) and p53 stabilization. The importance of this mechanism is underscored in 5q− syndrome, a macrocytic anemia caused by a large monoallelic deletion, which we found to also encompass the LARP1 gene...
July 6, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28673505/the-first-sign-of-loss-of-consciousness
#20
Typ Whinnery, Estrella M Forster
The first clinically observable sign of an unconsciousness episode (UNCE) serves as the temporal sequence (kinetics) onset point for neurological events occurring during the loss of consciousness, unconsciousness and recovery of consciousness phases of the UNCE. The initial neurologic signs of 212 individuals exposed to gradual (N=114) and rapid (N=98) onset +Gz acceleration stress, inducing the ischemic LOC phase in 83.3±18.6s and 8.89±1.52s; p<0.001 respectively, were determined. The duration of the unconscious phase (considered absolute incapacitation) was 10...
October 1, 2017: Physiology & Behavior
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