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Rapid-sequence induction

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https://www.readbyqxmd.com/read/29899136/neural-differentiation-selection-and-transcriptomic-profiling-of-human-neuromesodermal-progenitors-like-cells-in-vitro
#1
Laure Verrier, Lindsay Davidson, Marek Gierliński, Alwyn Dady, Kate G Storey
Robust protocols for directed differentiation of human pluripotent cells are required to determine whether mechanisms operating in model organisms are relevant to our own development. Recent work in vertebrate embryos has identified neuromesodermal progenitors as a bipotent cell population that contributes to paraxial mesoderm and spinal cord. However, precise protocols for in vitro differentiation of human spinal cord progenitors are lacking. Informed by signalling in amniote embryos, we show here that transient dual-SMAD inhibition, together with retinoic acid (dSMADi-RA), provides rapid and reproducible induction of human spinal cord progenitors from neuromesodermal progenitor-like cells...
June 13, 2018: Development
https://www.readbyqxmd.com/read/29878947/deep-neuromuscular-blockade-and-surgical-conditions-during-laparoscopic-ventral-hernia-repair-a-randomised-blinded-study
#2
Carl M Söderström, Roar Borregaard Medici, Sami Assadzadeh, Søren Følsgaard, Jacob Rosenberg, Mona R Gätke, Matias V Madsen
BACKGROUND: Laparoscopic ventral hernia repair is a common surgical procedure. However, muscle contractions and general muscle tension may impair the surgical view and cause difficulties suturing the hernial defect. Deep neuromuscular blockade (NMB) paralyses the abdominal wall muscles and may help to create better surgical conditions. OBJECTIVES: The current study investigated if deep compared with no NMB improved the surgical view during laparoscopic ventral hernia repair...
June 6, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29851051/systematic-review-and-meta-analysis-of-cricoid-pressure-training-and-education-efficacy
#3
REVIEW
Lorna Beckford, Cheryl Holly, Ronell Kirkley
We examined the evidence on the effectiveness of education and training on cricoid pressure (ie, Sellick maneuver) application. Cricoid pressure is used during rapid sequence induction and intubation to reduce the risk of pulmonary aspiration. We searched seven databases for studies on the education and training of health care personnel expected to apply cricoid pressure as a part of their regular clinical responsibilities. We appraised the included studies using standardized tools validated for this purpose and we performed a meta-analysis of the eight eligible studies...
June 2018: AORN Journal
https://www.readbyqxmd.com/read/29794121/prehospital-emergency-anaesthesia-an-updated-survey-of-uk-practice-with-emphasis-on-the-role-of-standardisation-and-checklists
#4
Mark R Burgess, Kate Crewdson, David J Lockey, Zane B Perkins
INTRODUCTION: Prehospital emergency anaesthesia (PHEA or 'prehospital rapid sequence intubation') is a high-risk procedure. Standard operating procedures (SOPs) and checklists within healthcare systems have been demonstrated to reduce human error and improve patient safety. We aimed to describe the current practice of PHEA in the UK, determine the use of checklists for PHEA and describe the content, format and layout of any such checklists currently used in the UK. METHOD: A survey of UK prehospital teams was conducted to establish the incidence and conduct of PHEA practice...
May 24, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29765548/transformation-of-mouse-t-cells-requires-myc-and-akt-activity-in-conjunction-with-inhibition-of-intrinsic-apoptosis
#5
Kari Högstrand, Stephanie Darmanin, TachaZi Plym Forshell, Alf Grandien
Peripheral T-cell lymphoma is an aggressive non-Hodgkin's lymphoma characterized by excessive proliferation of transformed mature T cells. The number and nature of genetic aberrations required and sufficient for transformation of normal T cells into lymphomas is unknown. Here, using a combinatorial in vitro -approach, we demonstrate that overexpression of MYC together with activated AKT in conditions of inhibition of intrinsic apoptosis rapidly resulted in transformation of mature mouse T cells with a frequency approaching 100%...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29750692/trainability-of-cricoid-pressure-force-application-a-simulation-based-study
#6
Eric Noll, Shivam Shodhan, Arnavi Varshney, Christopher Gallagher, Pierre Diemunsch, F Barry Florence, Jamie Romeiser, Elliott Bennett-Guerrero
BACKGROUND: Aspiration of gastric contents is a leading cause of airway management-related mortality during anesthesia practice. Cricoid pressure (CP) is widely used during rapid sequence induction to prevent aspiration. National guidelines for CP suggest a target force of 10 N before and 30 N after loss of consciousness. However, few studies have rigorously assessed whether clinicians can be trained to consistently achieve these levels of force. We hypothesized that clinicians can be trained effectively to deliver 10-30 N during application of CP...
May 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29744386/pulmonary-aspiration-during-intubation-in-a-high-risk-patient-a-video-clip-and-clinical-implications
#7
Gi-Ho Koh, Sung-Hoon Kim, Hyo-Jung Son, Jun-Young Jo, Seong-Soo Choi, Se-Ung Park, Wook-Jong Kim, Seung-Woo Ku
We report a case of pulmonary aspiration during induction of general anesthesia in a patient who was status post esophagectomy. Sudden, unexpected aspiration occurred even though the patient had fasted adequately (over 13 hours) and received rapid sequence anesthesia induction. Since during esophagectomy, the lower esophageal sphincter is excised, stomach vagal innervation is lost, and the stomach is flaccid, draining only by gravity, the patient becomes vulnerable to aspiration. As the incidence of perioperative pulmonary aspiration is relatively low, precautions to prevent aspiration tend to be overlooked...
April 2018: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29720758/ultra-modified-rapid-sequence-induction-with-transnasal-humidified-rapid-insufflation-ventilatory-exchange-challenging-convention
#8
Ketan Sakharam Kulkarni, Nandini Dave, Shriyam Saran, Madhu Garasia, Sandesh Parelkar
During positive pressure ventilation, gastric inflation and subsequent pulmonary aspiration can occur. Rapid sequence induction (RSI) technique is an age-old formula to prevent this. We adopted a novel approach of RSI for patients with high risk of aspiration and evaluated it further in patients undergoing laparoscopic surgeries. We believe that, in patients with risk of gastric insufflation and pulmonary aspiration, transnasal humidified rapid-insufflation ventilatory exchange can be useful in facilitating pre- and apnoeic oxygenation till tracheal isolation is achieved...
April 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29720506/induction-of-neoantigen-specific-cytotoxic-t-cells-and-construction-of-t-cell-receptor-engineered-t-cells-for-ovarian-cancer
#9
Tatsuo Matsuda, Matthias Leisegang, Jae-Hyun Park, Lili Ren, Taigo Kato, Yuji Ikeda, Makiko Harada, Kazuma Kiyotani, Ernst Lengyel, Gini F Fleming, Yusuke Nakamura
PURPOSE: Current evolution of cancer immunotherapies, such as immune checkpoint blockade, has implicated neoantigens as major targets of anti-cancer cytotoxic T cells. Adoptive T cell therapy with neoantigen-specific T cell receptor (TCR)-engineered T cells would be an attractive therapeutic option for advanced cancers where the host anti-tumor immune function is strongly inhibited. We previously developed a rapid and efficient pipeline for production of neoantigen-specific TCR-engineered T cells using peripheral blood from an HLA-matched healthy donor...
May 2, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29713291/byssus-structure-and-protein-composition-in-the-highly-invasive-fouling-mussel-limnoperna-fortunei
#10
Shiguo Li, Zhiqiang Xia, Yiyong Chen, Yangchun Gao, Aibin Zhan
Biofouling mediated by byssus adhesion in invasive bivalves has become a global environmental problem in aquatic ecosystems, resulting in negative ecological and economic consequences. Previous studies suggested that mechanisms responsible for byssus adhesion largely vary among bivalves, but it is poorly understood in freshwater species. Understanding of byssus structure and protein composition is the prerequisite for revealing these mechanisms. Here, we used multiple methods, including scanning electron microscope, liquid chromatography-tandem mass spectrometry, transcriptome sequencing, real-time quantitative PCR, inductively coupled plasma mass spectrometry, to investigate structure, and protein composition of byssus in the highly invasive freshwater mussel Limnoperna fortunei ...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29708920/airway-management-in-a-patient-with-tracheal-disruption-due-to-penetrating-neck-trauma-with-hollow-point-ammunition-a-case-report
#11
Angela M Johnson, James L Hill, Dave J Zagorski, Joseph M McClain, Nicole C Maronian
Rapid sequence induction and intubation was performed for a patient in respiratory distress after a gunshot wound to the neck. Resistance was noted distal to vocal cords. With a bronchoscope unavailable, the endotracheal tube was advanced with a corkscrew maneuver. Subcutaneous emphysema had developed. The endotracheal tube was advanced into the right mainstem with adequate ventilation. Imaging illustrated tracheoesophageal injury. The patient was emergently explored. An intraluminal bullet was removed, lateral wall tracheal defect was repaired, and a tracheostomy was placed...
May 1, 2018: A&A practice
https://www.readbyqxmd.com/read/29700275/anesthesia-management-of-modified-ex-vivo-liver-resection-and-autotransplantation
#12
Fujun Cheng, Zhiyong Yang, Jing Zeng, Jianteng Gu, Jian Cui, Jiaoning Ning, Bin Yi
BACKGROUND Ex situ liver surgery allows liver resection and vascular reconstruction in patients who have liver tumors located in critical sites. Only a small series of studies about ex situ liver surgery is available in the literature. No anesthesia management experience has been previously published. The aim of the currents study was to summarize our experience with anesthetic management of patients during ex vivo liver surgery. MATERIAL AND METHODS The first 43 patients who received ex vivo liver surgery between January 2007 and April 2012 were included...
April 27, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29693943/anesthetic-management-of-caesarean-section-in-a-patient-with-verapamil-sensitive-ventricular-tachycardia-after-catheter-ablation
#13
Minori Morita
A 32-year-old pregnant woman with verapamil sensitive ventricular tachycardia underwent elective caesarean section. She received catheter ablation for frequent tachycardia, but ventricular tachycardia appeared. In the operating room, a defibrillator pad was placed on her chest for external defibrillation, with A-line in a left radial artery. General anesthesia was started with rapid sequence induction. The anesthetic course was uneventful, and the infant showed no complication during the perioperative period...
May 2017: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/29679720/enhancement-of-peri-implant-bone-osteogenic-activity-induced-by-a-peptidomimetic-functionalization-of-titanium
#14
F Ravanetti, F Gazza, D D'Arrigo, G Graiani, A Zamuner, M Zedda, E Manfredi, M Dettin, A Cacchioli
Osteoblast cell adhesion to the extracellular matrix is established through two main pathways: one is mediated by the binding between integrin and a minimal adhesion sequence (RGD) on the extracellular protein, the other is based on the interactions between transmembrane proteoglycans and heparin-binding sequences found in many matrix proteins. The aim of this study is the evaluation in an in vivo endosseous implant model of the early osteogenic response of the peri-implant bone to a biomimetic titanium surface functionalized with the retro-inverso 2DHVP peptide, an analogue of Vitronectin heparin binding site...
July 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29679482/an-impurity-characterization-based-approach-for-the-rapid-development-of-integrated-downstream-purification-processes
#15
Steven M Timmick, Nicholas Vecchiarello, Chaz Goodwine, Laura E Crowell, Kerry R Love, J Christopher Love, Steven M Cramer
In this study, we describe a new approach for the characterization of process-related impurities along with an in silico tool to generate orthogonal, integrated downstream purification processes for biological products. A one-time characterization of process-related impurities from product expression in Pichia pastoris was first carried out using linear salt and pH gradients on a library of multimodal, salt-tolerant, and hydrophobic charge induction chromatographic resins. The Reversed-phase ultra-performance liquid chromatography (UPLC) analysis of the fractions from these gradients was then used to generate large data sets of impurity profiles...
April 21, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29661387/pre-hospital-advanced-airway-management-by-anaesthetist-and-nurse-anaesthetist-critical-care-teams-a-prospective-observational-study-of-2028-pre-hospital-tracheal-intubations
#16
M Gellerfors, E Fevang, A Bäckman, A Krüger, S Mikkelsen, J Nurmi, L Rognås, E Sandström, G Skallsjö, C Svensén, D Gryth, H M Lossius
BACKGROUND: Pre-hospital tracheal intubation success and complication rates vary considerably among provider categories. The purpose of this study was to estimate the success and complication rates of pre-hospital tracheal intubation performed by physician anaesthetist or nurse anaesthetist pre-hospital critical care teams. METHODS: Data were prospectively collected from critical care teams staffed with a physician anaesthetist or a nurse anaesthetist according to the Utstein template for pre-hospital advanced airway management...
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29628594/an-unusual-case-of-a-parturient-with-uncorrected-pentalogy-of-fallot-presenting-for-elective-cesarean-section-delivery-of-twins
#17
Ying Ci Ho, Sek Koon Boey, Abey Matthew Varughese Mathews, Hooi Geok See, Nian Chih Hwang
We present a 31-year-old primigravida with uncorrected pentalogy of Fallot, pregnant with monochorionic-diamniotic twins, undergoing elective lower segment cesarean section at 36 weeks gestation. Preoperative workup included a transthoracic echocardiogram which revealed a large ventricular septal defect of 1.8 cm with bidirectional shunting, a moderate size atrial septal defect of 1.8 cm with predominant left-to-right shunting, an overriding aorta, moderate right ventricular hypertrophy, and severe pulmonary valve stenosis...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29573111/a-tale-of-two-cities-prehospital-intubation-with-or-without-paralysing-agents-for-traumatic-brain-injury
#18
Cino Bendinelli, Dominic Ku, Shane Nebauer, Kate L King, Teresa Howard, Russel Gruen, Tiffany Evans, Mark Fitzgerald, Zsolt J Balogh
BACKGROUND: The role of prehospital endotracheal intubation (PETI) for traumatic brain injury is unclear. In Victoria, paramedics use rapid sequence induction (RSI) drugs to facilitate PETI, while in New South Wales (NSW) they do not have access to paralysing agents. We hypothesized that RSI would both increase PETI rates and improve mortality. METHODS: Retrospective comparison of adult primary admissions (Glasgow Coma Scale <9 and abbreviated injury scale head and neck >2) to either Victorian or NSW trauma centre, which were compared with univariate and logistic regression analysis to estimate odds ratio for mortality and intensive care unit (ICU) length of stay...
May 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29567177/quantitative-determination-of-total-cesium-in-highly-active-liquid-waste-by-using-liquid-electrode-plasma-optical-emission-spectrometry
#19
Van-Khoai Do, Masahiko Yamamoto, Shigeo Taguchi, Yuzuru Takamura, Naoki Surugaya, Takehiko Kuno
A sensitive analytical method for determination of total cesium (Cs) in highly active liquid waste (HALW) by using modified liquid electrode plasma optical emission spectrometry (LEP-OES) is developed in this study. The instrument is modified to measure radioactive samples in a glove box. The effects of important factors, including pulsed voltage sequence and nitric acid concentration, on the emission of Cs are investigated. The limit of detection (LOD) and limit of quantification (LOQ) are 0.005 mg/L and 0...
June 1, 2018: Talanta
https://www.readbyqxmd.com/read/29564834/experimental-induction-of-genome-chaos
#20
Christine J Ye, Guo Liu, Henry H Heng
Genome chaos, or karyotype chaos, represents a powerful survival strategy for somatic cells under high levels of stress/selection. Since the genome context, not the gene content, encodes the genomic blueprint of the cell, stress-induced rapid and massive reorganization of genome topology functions as a very important mechanism for genome (karyotype) evolution. In recent years, the phenomenon of genome chaos has been confirmed by various sequencing efforts, and many different terms have been coined to describe different subtypes of the chaotic genome including "chromothripsis," "chromoplexy," and "structural mutations...
2018: Methods in Molecular Biology
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