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Lumpectomy

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https://www.readbyqxmd.com/read/29152598/study-protocol-a-randomized-controlled-trial-of-a-comprehensive-breast-cancer-treatment-patient-decision-tool-icandecide
#1
Sarah T Hawley, Yun Li, L Alexandra Jeanpierre, Stefanie Goodell, Reshma Jagsi, Kevin C Ward, Michael S Sabel, Steven J Katz
Background: Patients newly diagnosed with breast cancer face a series of complex decisions regarding locoregional and systemic treatment. There is a need to improve the quality of locoregional and systemic decisions for breast cancer patients, and to help patients understand the role of evaluative tests in this decision process. We are now conducting a randomized controlled trial (RCT) of an online decision tool-called iCanDecide, which we expect will help patients with these difficult decisions...
March 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29132560/alternatives-to-standard-fractionation-radiation-therapy-after-lumpectomy-hypofractionated-whole-breast-irradiation-and-accelerated-partial-breast-irradiation
#2
REVIEW
Nisha Ohri, Bruce G Haffty
Adjuvant whole-breast irradiation (WBI) after lumpectomy has been an established standard of care for decades. Standard-fractionation WBI delivered over 5 to 7 weeks can achieve durable tumor control with low toxicity but can be inconvenient for patients and cost ineffective. Hypofractionated WBI can be completed in 3 to 4 weeks and, based on long-term randomized data, is the preferred standard of care in select patients. Accelerated partial-breast irradiation can be delivered using even shorter treatment regimens...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29128819/the-saw-tooth-operation-for-giant-fibroadenomas
#3
Vijay Naraynsingh, Lemuel Pran, Shariful Islam, Shamir Cawich
Fibroadenomas are the most common benign breast lesions affecting adolescents and young women. Cosmesis is an important factor when considering surgical management for these masses. Giant fibroadenomas (>5cm), because of their size, may require larger incisions resulting in significant scarring and scar complications in these young women. Several approaches have been employed, usually involving large incisions, when performing a lumpectomy for giant fibroadenomas. In this report, we highlight a new technique for removal of these masses, which allows the removal of large fibroadenomas through a relatively small, cosmetically acceptable, circumareolar incision...
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29127721/the-impact-of-preoperative-magnetic-resonance-imaging-and-lumpectomy-cavity-shavings-on-re-excision-rate-in-pure-ductal-carcinoma-in-situ-a-single-institution-s-experience
#4
Alycia So, Lucy M De La Cruz, Austin D Williams, Joseph Bahng, Geraldine Liao, Elizabeth S McDonald, Carla S Fisher, Brian J Czerniecki, Dahlia Sataloff, Julia Tchou
BACKGROUND AND OBJECTIVES: The impact of preoperative magnetic resonance imaging (pMRI) and cavity shave margins (CSM) on re-excision rate (RR) in DCIS is unclear. We investigated whether either modality was associated with RR in DCIS. METHODS: This is a single-institution retrospective study of 295 women undergoing breast conservation surgery for pure DCIS (2010-2013). CSM were the systematic resection of 4-6 margins during lumpectomy whereas selective shave margins (SSM) were the selective resection of 1-3 margins...
November 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29119692/impact-of-same-day-vs-day-before-pre-operative-lymphoscintigraphy-for-sentinel-lymph-node-biopsy-for-early-breast-cancer-local-australian-experience
#5
Yang Yang Huang, Amelie Maurel, Saud Hamza, Lee Jackson, Zeyad Al-Ogaili
INTRODUCTION: To assess the impact of delayed vs immediate pre-operative lymphoscintigraphy (LSG) for sentinel lymph node biopsy in a single Australian tertiary breast cancer centre. METHODS: Retrospective cohort study analysing patients with breast cancer or DCIS who underwent lumpectomy or mastectomy with pre-operative LSG and intra-operative sentinel lymph node biopsy from January 2015 to June 2016. RESULTS: A total of 182 LSG were performed...
November 9, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29110314/post-irradiation-morphoea-of-the-breast-a-case-report-and-review-of-the-literature
#6
Paula I Gonzalez-Ericsson, Monica V Estrada, Rami Al-Rohil, Melinda E Sanders
We describe a 44-year-old female with triple-negative breast cancer who developed skin erythaema, sclerosis and contracture of her entire right breast 15 months after completion of post-lumpectomy chemotherapy and radiotherapy, consistent with post-irradiation morphoea (PIM). PIM is a rare complication of breast irradiation that impairs a patient's quality of life. PIM is located usually at the radiation port or in the surrounding tissue. Clinically, PIM is misdiagnosed commonly as lymphoedema and cellulitis in the early inflammatory phase, and recurrent breast cancer, chronic radiodermatitis (CRD), radiation-induced fibrosis (RIF), post-irradiation pseudosclerodermatous panniculitis (PIPP), atypical vascular lesions (AVL) or angiosarcoma (AS) in the late burnout phase...
August 14, 2017: Histopathology
https://www.readbyqxmd.com/read/29099721/automated-detection-of-breast-cancer-in-resected-specimens-with-fluorescence-lifetime-imaging
#7
Jennifer E Phipps, Dimitris Gorpas, Jakob Unger, Morgan Darrow, Richard J Bold, Laura Marcu
Re-excision rates for breast cancer lumpectomy procedures are currently nearly 25% due to surgeons relying on inaccurate or incomplete methods of evaluating specimen margins. The objective of this study was to determine if cancer could be automatically detected in breast specimens from mastectomy and lumpectomy procedures by a classification algorithm that incorporated parameters derived from fluorescence lifetime imaging (FLIm). This study generated a database of co-registered histologic sections and FLIm data from breast cancer specimens (N=20) and a support vector machine (SVM) classification algorithm able to automatically detect cancerous, fibrous, and adipose breast tissue...
November 3, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29097927/comparison-of-diagnostic-performance-of-three-dimensional-positron-emission-mammography-versus-whole-body-positron-emission-tomography-in-breast-cancer
#8
Dong Dai, Xiuyu Song, Man Wang, Lin Li, Wenchao Ma, Wengui Xu, Yunchuan Ma, Juntian Liu, Jin Zhang, Peifang Liu, Xiaoyue Gu, Yusheng Su
Objective: To compare the diagnostic performance of three-dimensional (3D) positron emission mammography (PEM) versus whole body positron emission tomography (WBPET) for breast cancer. Methods: A total of 410 women with normal breast or benign or highly suspicious malignant tumors were randomized at 1 : 1 ratio to undergo 3D-PEM followed by WBPET or WBPET followed by 3D-PEM. Lumpectomy or mastectomy was performed on eligible participants after the scanning. Results: The sensitivity and specificity of 3D-PEM were 92...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29095189/venous-thromboembolism-after-surgical-treatment-of-breast-cancer
#9
Arash Momeni, Justin P Fox
BACKGROUND: Venous thromboembolism (VTE) remains a serious complication after the surgical treatment of breast cancer. Contemporary guidelines limit VTE chemoprophylaxis to the period of hospitalization. We conducted this study to evaluate the frequency of postdischarge VTE among surgically treated breast cancer patients and identify patient level factors associated with postdischarge VTE. METHODS: Using Arkansas, Florida, Nebraska, and New York state inpatient databases, we conducted a retrospective cohort study of adult women who underwent surgical treatment for breast cancer between October 1, 2008, and September 30, 2013...
October 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29089810/training-oncoplastic-breast-surgeons-the-canadian-fellowship-experience
#10
J Maxwell, A Arnaout, R Hanrahan, M Brackstone
BACKGROUND: Oncoplastic breast surgery combines traditional oncologic breast conservation with plastic surgery techniques to achieve improved aesthetic and quality-of-life outcomes without sacrificing oncologic safety. Clinical uptake and training remain limited in the Canadian surgical system. In the present article, we detail the current state of oncoplastic surgery (ops) training in Canada, the United States, and worldwide, as well as the experience of a Canadian clinical fellow in ops...
October 2017: Current Oncology
https://www.readbyqxmd.com/read/29080650/modern-approaches-to-the-surgical-management-of-malignant-breast-disease-the-role-of-breast-conservation-complete-mastectomy-skin-and-nipple-sparing-mastectomy
#11
REVIEW
Tulin D Cil, David McCready
The armamentarium of the modern breast surgeon includes the time-tested procedures of modified radical mastectomy and lumpectomy with sentinel lymph node biopsy with postoperative radiation, but has evolved to include several options that produce excellent oncologic endpoints and improved cosmesis. These options include skin- and nipple-sparing mastectomies with immediate reconstruction as well as oncoplastic procedures that allow larger excisions and better postoperative breast shape. This article provides an overview of these modern surgical approaches for breast cancer treatment...
January 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29072347/technical-note-dosimetric-impact-of-spherical-applicator-size-in-intrabeam-%C3%A2-iort-for-treating-unicentric-breast-cancer-lesions
#12
Yaseen Saleh, Hualin Zhang
PURPOSE: To characterize the dosimetric impact of using different sizes of spherical applicators in Intrabeam(™) Intraoperative Radiation Therapy (IB-IORT) to treat unicentric cancer lesions after breast-conserving lumpectomy. METHODS: Using the commissioned depth dose rates, the three-dimensional dosages of the 3.5, 4.0, 4.5, and 5.0 cm spherical applicators of the IB-IORT PRS400 machine were established. Five different cancer cell infiltration depths of unicentric breast lesions were formulated by a linearly declining cancer cell density distribution from the surgical surface...
October 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/29064749/variability-of-postsurgical-imaging-surveillance-of-breast-cancer-patients-a-nationwide-survey-study
#13
Bhavika K Patel, Cindy S Lee, Heidi E Kosiorek, Mary S Newell, Victor J Pizzitola, Carl J D'Orsi
OBJECTIVE: Because of observed clinical variance and the discretion of referring physicians and radiologists in patient follow-up, the purpose of this study was to conduct a survey to explore whether broad discrepancy exists in imaging protocols used for postsurgical surveillance. SUBJECTS AND METHODS: An online survey was created to assess radiologists' use of diagnostic versus screening mammography for women with a personal history of breast cancer and determine whether the choice of protocol was associated with practice characteristics (setting, region, and reader type)...
October 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29059428/cost-effectiveness-analysis-comparing-conventional-hypofractionated-and-intraoperative-radiotherapy-for-early-stage-breast-cancer
#14
COMPARATIVE STUDY
Ashish A Deshmukh, Shervin M Shirvani, Lincy Lal, J Michael Swint, Scott B Cantor, Benjamin D Smith, Anna Likhacheva
Background: Early-stage breast cancer is among the most prevalent and costly malignancies treated in the American health care system. Adjuvant radiotherapy after lumpectomy represents a substantial portion of breast cancer expenditures. The relative value of novel radiotherapeutic approaches such as intraoperative radiotherapy (IORT) and hypofractionated whole breast irradiation (HF-WBI) compared with conventionally fractionated whole breast irradiation (CF-WBI) is unknown. Therefore, we used prospectively collected outcomes from randomized clinical trials (RCTs) to compare the cost-effectiveness of these approaches...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29053170/radiation-therapy-utilization-in-medicare-beneficiaries-with-early-stage-breast-cancer
#15
Audrey S Wallace, Kimberley S Keene, Courtney P Williams, Bradford E Jackson, Maria Pisu, Edward E Partridge, Gabrielle B Rocque
BACKGROUND: There is increasing evidence that radiation therapy (RT) can be omitted for select older patients who are compliant with hormonal blockade, but there is no recent claim-based analysis for determining patterns of care and guiding possible treatment recommendations. METHODS: Medicare beneficiaries who were 65 years old or older and were diagnosed with breast cancer at 1 of 12 cancer centers affiliated with an academic center in the southeastern United States were analyzed...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29043480/body-mass-index-bmi-postoperative-appearance-satisfaction-and-sexual-function-in-breast-cancer-survivorship
#16
K E Rojas, N Matthews, C Raker, M A Clark, M Onstad, A Stuckey, J Gass
PURPOSE: We sought to explore the correlation between BMI and postoperative sexual function, body image, and breast-specific sensuality before and after breast cancer surgery. METHODS: A cross-sectional survey of patients at least 1 year from surgery employed the Female Sexual Function Index (FSFI) and investigator-generated questions. Patients who underwent lumpectomy (L), mastectomy (M), and mastectomy with reconstruction (MR) were compared across three BMI groups: normal weight, overweight, and obese...
October 17, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29039119/clinical-implications-of-germline-mutations-in-breast-cancer-tp53
#17
REVIEW
Katherine Schon, Marc Tischkowitz
PURPOSE: This review describes the prevalence of germline TP53 mutations, the risk of breast cancer and other cancers in mutation carriers and management implications for women with breast cancer and unaffected women. METHODS: Literature review of English language papers available through PubMed. RESULTS: Women who carry germline mutations in the TP53 gene have a very high risk of breast cancer of up to 85% by age 60 years. Most of these breast cancers are early onset with a median age at diagnosis of 34 years...
October 16, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28990155/treatment-decisions-and-employment-of-breast-cancer-patients-results-of-a-population-based-survey
#18
Reshma Jagsi, Paul H Abrahamse, Kamaria L Lee, Lauren P Wallner, Nancy K Janz, Ann S Hamilton, Kevin C Ward, Monica Morrow, Allison W Kurian, Christopher R Friese, Sarah T Hawley, Steven J Katz
BACKGROUND: Many patients with breast cancer work for pay at the time of their diagnosis, and the treatment plan may threaten their livelihood. Understanding work experiences in a contemporary population-based sample is necessary to inform initiatives to reduce the burden of cancer care. METHODS: Women who were 20 to 79 years old and had been diagnosed with stage 0 to II breast cancer, as reported to the Georgia and Los Angeles Surveillance, Epidemiology, and End Results registries in 2014-2015, were surveyed...
October 9, 2017: Cancer
https://www.readbyqxmd.com/read/28985858/increase-in-contralateral-prophylactic-mastectomy-conversation-online-unrelated-to-decision-making
#19
Rebecca A Marmor, Wenrui Dai, Xiaoqian Jiang, Shuang Wang, Sarah L Blair, Jina Huh
BACKGROUND: The increased uptake of contralateral prophylactic mastectomy (CPM) among breast cancer patients remains poorly understood. We hypothesized that the increased rate of CPM is represented in conversations on an online breast cancer community and may contribute to patients choosing this operation. METHODS: We downloaded 328,763 posts and their dates of creation from an online breast cancer community from August 1, 2000, to May 22, 2016. We then performed a keyword search to identify posts which mentioned breast cancer surgeries: contralateral prophylactic mastectomy (n = 7095), mastectomy (n = 10,889), and lumpectomy (n = 9694)...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28984579/follow-up-of-patients-undergoing-oncoplastic-surgery-more-palpable-masses-and-benign-biopsies
#20
Yoav Amitai, Orit Golan, Yoav Barnea, Joseph Klausner, Tehillah S Menes
BACKGROUND: Oncoplastic reconstruction is increasingly used in the management of women undergoing breast conserving surgery. We examined the findings on breast exam and imaging of patients who underwent breast conservation with or without oncoplastic reconstruction. OBJECTIVE: We hypothesized that patients undergoing immediate breast reconstruction would present with more palpable and imaging abnormalities compared to lumpectomy alone and undergo therefore more biopsies...
October 3, 2017: Breast Disease
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