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https://www.readbyqxmd.com/read/29338088/margins-in-breast-cancer-how-much-is-enough
#1
REVIEW
Melissa Pilewskie, Monica Morrow
The appropriate negative margin width for women undergoing breast-conserving surgery for both ductal carcinoma in situ (DCIS) and invasive carcinoma is controversial. This review examines the available data on the margin status for invasive breast cancer and DCIS, and highlights the similarities and differences in tumor biology and standard treatments that affect the local recurrence (LR) risk and, therefore, the optimal surgical margin. Consensus guidelines support a negative margin, defined as no ink on tumor, for invasive carcinoma treated with breast-conserving therapy...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29334788/latissimus-dorsi-flap-in-breast-reconstruction-recent-innovations-in-the-workhorse-flap
#2
Rachita Sood, Jeena M Easow, Geoffrey Konopka, Zubin J Panthaki
BACKGROUND: Surgeons employ the latissimus dorsi flap (LDF) for reconstruction of a large variety of breast cancer surgery defects, including quadrantectomy, lumpectomy, modified radical mastectomy, and others. The LDF may be used in delayed or immediate reconstruction, in combination with tissue expanders for a staged reconstruction, with implant-based immediate reconstruction, or alone as an autogenous flap. METHODS: The authors discuss the historical uses and more recent developments in the LDF...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29325566/male-breast-cancer-diagnosis-stages-treatment-and-survival-in-a-country-with-limited-resources-burkina-faso
#3
Nayi Zongo, Smaïla Ouédraogo, Nina Korsaga-Somé, Ollo Roland Somé, Naïma Go, Edgar Ouangré, Maurice Zida, Gilbert Bonkoungou, Aimé Sosthène Ouédraogo, Aboubacar Hirrum Bambara, Bambara Augustin Tozoula, Si Simon Traoré, Ahmadou Dem, Pascal Niamba, Adama Traoré, Adama Sanou, Danielé Grazziotin Soares, Jean-Pierre Lotz
BACKGROUND: Male breast cancer is a rare and less known disease. Therapeutic modalities affect survival. In Burkina Faso, male breast cancers are diagnosed in everyday practice, but the prognosis at short-, middle-, and long-term remains unknown. The objective of this study is to study the diagnosis stages, therapeutic modalities, and 5-year survival in male breast cancer at the General Surgery Unit of Yalgado Ouedraogo University Hospital from 1990 to 2009. METHODS: A cohort longitudinal study concerning cases of breast cancer diagnosed in man...
January 11, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29322287/metaplastic-breast-cancer-practice-patterns-outcomes-and-the-role-of-radiotherapy
#4
Waqar Haque, Vivek Verma, Nilan Naik, E Brian Butler, Bin S Teh
PURPOSE: Metaplastic breast cancer (MBC) is a rare, aggressive form of breast cancer with limited data to guide management. This study of a large, contemporary US database described national practice patterns and addressed the impact of radiotherapy (RT) on survival. METHODS: The National Cancer Data Base was queried (2004-2013) for women with non-metastatic MBC. Multivariable logistic regression ascertained factors associated with RT administration. Kaplan-Meier analysis evaluated overall survival (OS) between patients treated with either lumpectomy or mastectomy with or without RT, while substratifying patients into pT1-2N0 and pT3-4/N+ subcohorts...
January 10, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29305733/preclinical-ex-vivo-evaluation-of-the-diagnostic-performance-of-a-new-device-for-in-situ-label-free-fluorescence-spectral-analysis-of-breast-masses
#5
Marie-Christine Mathieu, Alexis Toullec, Charlotte Benoit, Richard Berry, Pierre Validire, Pauline Beaumel, Yves Vincent, Pierre Maroun, Philippe Vielh, Lama Alchab, René Farcy, Hélène Moniz-Koum, Marie-Pierre Fontaine-Aupart, Suzette Delaloge, Corinne Balleyguier
OBJECTIVES: To assess the diagnostic performance of a new device for in situ label-free fluorescence spectral analysis of breast masses in freshly removed surgical specimens, in preparation for its clinical development. METHODS: Sixty-four breast masses from consenting patients who had undergone either a lumpectomy or a mastectomy were included. Label-free fluorescence spectral acquisitions were obtained with a 25G fibre-containing needle inserted into the mass...
January 5, 2018: European Radiology
https://www.readbyqxmd.com/read/29290325/-adenomyoepithelioma-of-the-breast-report-of-four-cases-and-literature-review
#6
Cristina Díaz Del Arco, Lourdes Estrada Muñoz, Alejandro Pascual Martín, Adela Pelayo Alarcón, David de Pablo Velasco, Luis Ortega Medina
Adenomyoepitheliomas of the breast are infrequent tumors with a variable histological appearance, and they can mimic several epithelial, myoepithelial and biphasic lesions of the breast. We have reviewed four cases of adenomyoepithelioma of the breast diagnosed between 2005 and 2015 in our institution (Hospital Clínico San Carlos). Mean age was 57years. All lesions were solid irregular masses located in the upper quadrants (3 of them in the right breast and one in the left), with an average size of 13mm. Microscopically 2 of them were tubular and the remaining 2 were lobulated subtypes...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29273054/significant-suppression-of-radiation-dermatitis-in-breast-cancer-patients-using-a-topically-applied-adrenergic-vasoconstrictor
#7
James F Cleary, Bethany M Anderson, Jens C Eickhoff, Deepak Khuntia, William E Fahl
BACKGROUND: Our previous studies showed that vasoconstrictor applied topically to rat skin minutes before irradiation completely prevented radiodermatitis. Here we report on a Phase IIa study of topically applied NG12-1 vasoconstrictor to prevent radiodermatitis in post-lumpectomy breast cancer patients who received at least 40 Gray to the whole breast using standard regimens. METHODS: Patients had undergone surgery for Stage Ia, Ib, or IIa infiltrating ductal or lobular carcinoma of the breast or ductal carcinoma in situ...
December 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29247967/early-stage-malignant-phyllodes-tumor-case-report
#8
Thao Wolbert, Emilia C N Leigh, Rahman Barry, Jack R Traylor, Mary Legenza
INTRODUCTION: Malignant phyllodes tumor of the breast is an extremely rare entity usually presenting with similar clinical features with those of benign fibroadenoma. Due to its scarcity and clinical presentation, it is quite difficult for clinicians to suspect and diagnose the disease at its early stage. There is currently no consensus regarding adjunctive radiotherapy, hormonal therapy and systemic chemotherapy recommended for malignant phyllodes tumors. PRESENTATION OF CASE: This report presents a case of early-stage malignant phyllodes tumor treated by lumpectomy only without adjunctive chemoradiation therapy, but with an excellent outcome...
December 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29246706/how-well-informed-do-patients-feel-about-their-breast-cancer-surgery-options-findings-from-a-nationwide-survey-of-women-after-lumpectomy-and-or-mastectomy
#9
Sunny Mitchell, Jennifer Gass, Michael Hanna
BACKGROUND: Women diagnosed with breast cancer often describe the process of treatment decision making as bewildering and worrisome. Patients who do not feel completely informed about their surgical options might make choices that are suboptimal or regretted later. The Institute of Medicine has called for more research on why breast cancer patients are inadequately informed about treatment options. The aims of the study were to explore how women become informed about their breast cancer surgery treatment options and to identify improvement opportunities...
December 12, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29238824/effect-of-perioperative-gabapentin-on-postoperative-pain-resolution-and-opioid-cessation-in-a-mixed-surgical-cohort-a-randomized-clinical-trial
#10
Jennifer Hah, Sean C Mackey, Peter Schmidt, Rebecca McCue, Keith Humphreys, Jodie Trafton, Bradley Efron, Debra Clay, Yasamin Sharifzadeh, Gabriela Ruchelli, Stuart Goodman, James Huddleston, William J Maloney, Frederick M Dirbas, Joseph Shrager, John Costouros, Catherine Curtin, Ian Carroll
Importance: Guidelines recommend using gabapentin to decrease postoperative pain and opioid use, but significant variation exists in clinical practice. Objective: To determine the effect of perioperative gabapentin on remote postoperative time to pain resolution and opioid cessation. Design, Setting, and Participants: A randomized, double-blind, placebo-controlled trial of perioperative gabapentin was conducted at a single-center, tertiary referral teaching hospital...
December 13, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29234899/correction-to-ten-year-results-of-accelerated-hypofractionated-adjuvant-whole-breast-radiation-with-concomitant-boost-to-the-lumpectomy-cavity-after-conserving-surgery-for-early-breast-cancer
#11
Domenico Cante, Edoardo Petrucci, Piera Sciacero, Cristina Piva, Silvia Ferrario, Silvia Bagnera, Sebastiano Patania, Guido Mondini, Massimo Pasquino, Valeria Casanova Borca, Giorgio Vellani, Maria Rosa La Porta, Pierfrancesco Franco
An error inadvertently occurred in the discussion of the original publication when citing the local relapse rates of the EORTC 22881-10882 trial ('boost vs no boost trial').
December 12, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29234253/evaluation-of-sentinel-lymph-node-biopsy-and-axillary-lymph-node-dissection-for-breast-cancer-treatment-concepts-a-retrospective-study-of-1-214-breast-cancer-patients
#12
Roland G Stein, Roland Fricker, Thomas Rink, Hartmut Fitz, Sebastian Blasius, Joachim Diessner, Sebastian F M Häusler, Tanja N Stüber, Victoria Andreas, Achim Wöckel, Thomas Müller
Background: Most breast cancer patients require lumpectomy with axillary sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND). The ACOSOG Z0011-trial failed to detect significant effects of ALND on disease-free and overall survival among patients with limited sentinel lymph node (SLN) metastases. Intense dose-dense chemotherapy and supraclavicular fossa radiation (SFR) are indicated for patients with extensive axillary metastases. In this multicentered study, we investigated the relevance of ALND after positive SLNB to determine adequate adjuvant therapy...
October 2017: Breast Care
https://www.readbyqxmd.com/read/29230119/a-potential-additional-variable-to-consider-in-the-surgical-treatment-of-ductal-carcinoma-in-situ
#13
Katherine Chaisson, Amy Rivere, Ralph Corsetti, Tova Weiss, George M Fuhrman
Background: HER2/neu is a potentially interesting variable that has been demonstrated to have a profound impact on the management of invasive breast carcinoma, and we performed this study to evaluate the differences between HER2-positive and HER2-negative ductal carcinoma in situ. The impetus for this study was our poor recruitment to the National Surgical Adjuvant Breast and Bowel Project Protocol B-43 trial that was designed to evaluate the potential role of trastuzumab in breast conservation therapy for patients with HER2-positive ductal carcinoma in situ...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229142/improvement-of-consistency-in-delineating-breast-lumpectomy-cavity-using-surgical-clips
#14
Siavash Atrchian, Pejman Sadeghi, Wladyslawa Cwajna, Lucy Helyer, Dorianne Rheaume, Maureen Nolan, Parisa Sadeghi, James Robar
BACKGROUND: Delineation of lumpectomy cavity for whole breast radiation therapy after breast conserving surgery can be challenging because of poor visualization of the cavity. The use of surgical clips on lumpectomy cavity walls has been suggested as an effective and low-cost method to improve the accuracy and consistency of lumpectomy cavity delineation. MATERIALS AND METHODS: Twenty-three eligible female breast cancer patients who were treated with lumpectomy and adjuvant radiation therapy were recruited for this study...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29222935/risk-factors-for-positive-resection-margins-of-breast-cancer-tumorectomy-specimen-following-breast-conserving-surgery
#15
Niko Heiss, Valentin Rousson, Assia Ifticene-Treboux, Hans-Anton Lehr, Jean-François Delaloye
Background The aim of the study was to identify risk factors for positive surgical margins in breast-conserving surgery for breast cancer and to evaluate the influence of surgical experience in obtaining complete resection. Methods All lumpectomies for invasive breast carcinoma and ductal carcinoma in situ (DCIS) between April 2008 and March 2010 were selected from the database of a single institution. Re-excision rates for positive margins as well as patient and histopathologic tumor characteristics were analyzed...
December 9, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29197477/neoadjuvant-systemic-therapy-in-invasive-lobular-breast-cancer-is-it-indicated
#16
Karen Tsung, Stephen R Grobmyer, Chao Tu, Jame Abraham, G Thomas Budd, Stephanie A Valente
BACKGROUND: This study investigated patients with invasive lobular breast carcinoma (ILC) to determine the benefit of neoadjuvant systemic therapy (NAST). METHODS: Patients with ILC treated from 2006 to 2015 were identified. Tumor characteristics and treatment data were analyzed. RESULTS: Of the 560 patients with ILC, 77 patients received NAST. Patients who received NAST presented with larger clinical T stages compared to patients who received surgery first (p < 0...
November 14, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29191356/a-novel-modality-for-intraoperative-margin-assessment-and-its-impact-on-re-excision-rates-in-breast-conserving-surgery
#17
Amanda Kupstas, Warda Ibrar, R David Hayward, David Ockner, Cheryl Wesen, Jeffrey Falk
BACKGROUND: A single center retrospective chart review was performed examining the ability of a novel radiofrequency probe (Margin Probe; Dune Medical Devices, Caesarea, Israel) for intraoperative margin assessment to reduce the number of reexcisions in breast-conserving surgery. METHODS: Reexcision rates were evaluated in one-hundred and twenty consecutive patients before and after the institution of the device. Utility of the device was evaluated by comparing intraoperative feedback with postoperative pathology reports...
November 21, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29188405/promoting-effects-of-adipose-derived-stem-cells-on-breast-cancer-cells-are-reversed-by-radiation-therapy
#18
Annemarie Baaße, Dajana Juerß, Elaine Reape, Katrin Manda, Guido Hildebrandt
Partial breast irradiation of early breast cancer patients after lumpectomy and the use of endogenous adipose tissue (AT) for breast reconstruction are promising applications to reduce the side effects of breast cancer therapy. This study tries to investigate the possible risks associated with these therapeutic approaches. It also examines the influence of adipose derived stem cells (ADSCs) as part of the breast cancer microenvironment, and endogenous AT on breast cancer cells following radiation therapy. ADSCs, isolated from human reduction mammoplasties of healthy female donors, exhibited multilineage capacity and specific surface markers...
November 29, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29187920/-benign-tumors-of-the-breast-in-the-department-of-senology-at-the-university-hospital-aristide-le-dantec-dakar-senegal
#19
Serigne Modou Kane Gueye, Mamour Gueye, Mariétou Thiam Coulibaly, Diana Mahtouk, Jean Charles Moreau
Introduction: This study aimed to identify the epidemiological, clinical and therapeutic features of benign tumors of the breast treated in the department of senology at the university hospital Aristide Le Dantec, Dakar. Methods: We conducted a cross-sectional, descriptive and analytical study of 220 patients treated in the Department of Senology at the University Hospital Aristide Le Dantec, Dakar over the period from 1 January 2008 to 31 December 2013. Results: 220 patients out of 984 consultants had benign tumor of the breast (22...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29187430/the-yin-and-yang-of-platelet-rich-plasma-in-breast-reconstruction-after-mastectomy-or-lumpectomy-for-breast-cancer
#20
REVIEW
Eleftherios Spartalis, Diamantis I Tsilimigras, Petros Charalampoudis, Georgia-Sofia Karachaliou, Demetrios Moris, Antonios Athanasiou, Michael Spartalis, Vasileios Bolkas, Dimitrios Dimitroulis, Nikolaos Nikiteas
Surgery remains the mainstay of treatment for breast cancer, including complete or partial mastectomy and lumpectomy. Breast reconstruction has gained popularity mainly due to its tremendous impact on the psychological status of the patients. Autologous fat grafting is a well-established method used in cosmetic surgery; however, fat re-absoprtion, fat necrosis, calcifications and oil-cyst formation are some usually encountered complications limiting the efficacy of this approach. Platelet-rich plasma (PRP) has recently been postulated as a promising method for tissue regeneration since it contains high levels of diverse human growth factors...
December 2017: Anticancer Research
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