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https://www.readbyqxmd.com/read/29748884/predictors-of-residual-disease-after-breast-conservation-surgery
#1
Lisa J Findlay-Shirras, Oussama Outbih, Charlene N Muzyka, Katie Galloway, Pamela C Hebbard, Maged Nashed
INTRODUCTION: Breast-conserving therapy is the standard of care for early-stage breast cancer. In the era of multimodality therapy, the debate on the value of revision surgery for compromised margins continues, and high re-excision rates persist despite updated guidelines. Our study sought to identify the local re-excision rate for compromised margins after lumpectomy, and identify predictors of residual disease at re-excision. METHODS: This population-based retrospective cohort study included women with breast cancer who underwent a lumpectomy between 2009 and 2012 in Manitoba, with close (≤ 2 mm) or positive margins that led to re-excision...
May 10, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29745104/topically-applied-vasoconstrictor-while-decreasing-radiation-dermatitis-may-increase-local-recurrences-in-post-lumpectomy-breast-cancer-patients-who-received-radiotherapy
#2
Kadri Altundag
No abstract text is available yet for this article.
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29733543/disparities-in-breast-cancer-a-multi-institutional-comparative-analysis-focusing-on-american-hispanics
#3
Zeina Nahleh, Salman Otoukesh, Hamid Reza Mirshahidi, Anthony Loc Nguyen, Gayathri Nagaraj, Gehan Botrus, Nabeel Badri, Nabih Diab, Andres Alvarado, Luis A Sanchez, Alok K Dwivedi
Breast cancer (BC) is the leading cause of cancer death in Hispanic/Latino women nationwide. Hispanic women are more likely to be presented with advanced disease and adverse prognosis subtypes. The aim of this study is to describe the clinico- pathological characteristics and disparities in breast cancer in this group at two tertiary care University-based medical centers. After IRB approval, Cancer registry was used to analyze the variables of 3441 patients with breast cancer diagnosed and treated consecutively at two large tertiary University based medical and cancer center database centers in El Paso, TX and Loma Linda, CA between 2005 and 2015...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29731165/encapsulated-papillary-carcinoma-of-the-breast-a-clinicopathological-study-of-49-cases
#4
Xiaomei Li, Yanmei Xu, Hong Ye, Shuming Qin, Feng Hou, Wenlou Liu
BACKGROUND: Encapsulated papillary carcinoma (EPC) has been considered as a variant of ductal carcinoma in situ. Recent studies suggest that EPC could be invasive, as it often lacks myoepithelial cells (MECs) at their periphery. The current study was performed to investigate the biological features of EPC. METHODS: Forty-nine EPC patients admitted to the Tai'an Central Hospital and Qilu Hospital of Shandong University from January 2004-December 2014 were included in this study...
March 30, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29730916/-the-influence-of-lumpectomy-on-the-axillary-lymph-node-status-of-breast-cancer-patients
#5
D C Jiao, J J Zhu, J H Qiao, L N Wang, Y Z Ma, Z D Lu, Z Z Liu
Objective: To investigate the influence of lumpectomy on axillary lymph node status of breast cancer patients. Methods: The clinical data of 738 invasive breast cancer patients with non-palpable axillary lymph node and sentinel lymph node (SLN) biopsy from November 2011 to August 2013 in Henan Provincial Cancer Hospital were collected and retrospectively analyzed. Among them, 136 patients underwent preoperative lumpectomy (lumpectomy group) and 602 patients underwent puncture biopsy only (biopsy group). The difference of axillary lymph node status and positive ratio of SLN detected by color Doppler ultrasound were compared between these two groups...
April 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29719429/prescribing-practices-of-endocrine-therapy-for-ductal-carcinoma-in-situ-in-british-columbia
#6
A T Chaudhry, T A Koulis, C Speers, R A Olson
Purpose: The mainstay of treatment for ductal carcinoma in situ (dcis) involves surgery in the form of mastectomy or lumpectomy. Inconsistency in the use of endocrine therapy (et) for dcis is evident worldwide. We sought to assess the variation in et prescribing for patients with dcis across a population-based radiotherapy (rt) program and to identify variables that predict its use. Methods: Data from a breast cancer database were obtained for women diagnosed with dcis in British Columbia from 2009 to 2014...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29718314/simulation-modeling-of-cancer-clinical-trials-application-to-omitting-radiotherapy-in-low-risk-breast-cancer
#7
Jinani Jayasekera, Yisheng Li, Clyde B Schechter, Reshma Jagsi, Juhee Song, Julia White, George Luta, Judith-Anne W Chapman, Eric J Feuer, Richard C Zellars, Natasha Stout, Thomas B Julian, Timothy Whelan, Xuelin Huang, E Shelley Hwang, Judith O Hopkins, Joseph A Sparano, Stewart J Anderson, Anthony W Fyles, Robert Gray, Willi Sauerbrei, Jeanne Mandelblatt, Donald A Berry
Background: We used two models to simulate a proposed noninferiority trial of radiotherapy (RT) omission in low-risk invasive breast cancer to illustrate how modeling could be used to predict the trial's outcomes, inform trial design, and contribute to practice debates. Methods: The proposed trial was a prospective randomized trial of no-RT vs RT in women age 40 to 74 years undergoing lumpectomy and endocrine therapy for hormone receptor-positive, human epidermal growth factor receptor 2-negative, stage I breast cancer with an Oncotype DX score of 18 or lower...
April 28, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29716450/evaluation-of-surgical-instruments-with-radiofrequency-identification-tags-in-the-operating-room
#8
Kazuhiko Yamashita, Kaori Kusuda, Yoshitomo Ito, Masaru Komino, Kiyohito Tanaka, Satoru Kurokawa, Michitaka Ameya, Daiji Eba, Ken Masamune, Yoshihiro Muragaki, Yuji Ohta, Chugo Rinoie, Kenji Yamada, Yoshiki Sawa
BACKGROUND: Surgical instrument retention and instrument breakage compromise surgery quality and lead to medical malpractice. We developed an instrument tracking system that could alert surgeons to instrument retention during surgery and monitor instrument use to reduce the risk of breakage. METHODS: This prospective, experimental clinical trial included 15 patients undergoing inguinal hernia surgery or lumpectomy under general anesthesia at Saiseikai Kurihashi Hospital...
April 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29688847/the-cosmam-trial-a-prospective-cohort-study-of-quality-of-life-and-cosmetic-outcome-in-patients-undergoing-breast-conserving-surgery
#9
Coriene J L M Catsman, Martinus A Beek, Adri C Voogd, Paul G H Mulder, Ernest J T Luiten
BACKGROUND: Cosmetic result in breast cancer surgery is gaining increased interest. Currently, some 30-40% of the patients treated with breast conserving surgery (BCS) are dissatisfied with their final cosmetic result. In order to prevent disturbing breast deformity oncoplastic surgical techniques have been introduced. The extent of different levels of oncoplastic surgery incorporated in breast conserving surgery and its value with regard to cosmetic outcome, patient satisfaction and quality of life remains to be defined...
April 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29687530/radiographically-guided-shave-margins-may-reduce-lumpectomy-re-excision-rates
#10
Kelsey E Larson, Priya Jadeja, Alison Marko, Veeraj Jadeja, Debra Pratt
Minimizing margin re-excision optimizes patient care by providing appropriate oncologic resection and reducing costs. This study aims to assess margin positivity rate in two groups: shave margin based on gross specimen (control group, CG) vs shave margin based on intraoperative imaging (radiographic group, RG). A total of 182 patients who underwent lumpectomy for stage O-III breast cancer at a single institution from January 2013 to January 2014 were evaluated. There was statistically significant decrease in margin re-excision rate with intraoperative mammography but not with ultrasound...
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29673384/prognostic-factors-of-radiation-dermatitis-following-passive-scattering-proton-therapy-for-breast-cancer
#11
Xiaoying Liang, Julie A Bradley, Dandan Zheng, Michael Rutenberg, Daniel Yeung, Nancy Mendenhall, Zuofeng Li
BACKGROUND: To identify prognostic factors for grade 3 radiation dermatitis following passive-scattering proton therapy for breast cancer. METHODS: This retrospective study included data on 23 (11 post-mastectomy and 12 post-lumpectomy) breast cancer patients who underwent proton therapy with the passive scattering technique in our institute from 2012 to 2016. Each patient received 50-50.4 cobalt Gy equivalent (CGE) at 1.8 or 2 CGE per daily fraction. Logistic regression analysis was performed to identify prognostic factors for grade 3 skin toxicity...
April 19, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29671140/profiling-surgeon-performance-for-breast-cancer-lumpectomy-by-composite-measurement-of-reoperations-cosmetic-outcomes-and-patient-preferences
#12
Annie L Dunham, Luis D Ramirez, Choua A Vang, Jared H Linebarger, Jeffrey Landercasper
BACKGROUND: Patients want information to search for destination of care for breast-conserving surgery (BCS). To inform patients wanting a lumpectomy, we aimed to develop a pilot project that communicated composite quality measure (QM) results using a '4-star' rating system. Two patient-centered QMs were included in the model-reoperation rate (ROR) and cosmetic outcome (COSM). METHODS: A prospective database was reviewed for stage 0-3 patients undergoing initial lumpectomy by three surgeons from 2010 to 2015...
April 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29669187/patient-views-and-correlates-of-radiotherapy-omission-in-a-population-based-sample-of-older-women-with-favorable-prognosis-breast-cancer
#13
Dean A Shumway, Kent A Griffith, Sarah T Hawley, Lauren P Wallner, Kevin C Ward, Ann S Hamilton, Monica Morrow, Steven J Katz, Reshma Jagsi
BACKGROUND: The omission of radiotherapy (RT) after lumpectomy is a reasonable option for many older women with favorable-prognosis breast cancer. In the current study, we sought to evaluate patient perspectives regarding decision making about RT. METHODS: Women aged 65 to 79 years with AJCC 7th edition stage I and II breast cancer who were reported to the Georgia and Los Angeles County Surveillance, Epidemiology, and End Results registries were surveyed (response rate, 70%) regarding RT decisions, the rationale for omitting RT, decision-making values, and understanding of disease recurrence risk...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29661737/a-rapid-triage-protocol-to-optimize-cold-ischemic-time-for-breast-resection-specimens
#14
Ellen G East, Matthew Gabbeart, Emily Roberts, Lili Zhao, Julie M Jorns
Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens. Current guidelines recommend CIT of ≤1 h. Since formalin penetrates resections slowly, optimal fixation requires incision. We evaluated the efficacy of a rapid triage protocol developed to optimize CIT. We identified 2821 specimens: 650 (23.0%) excisional biopsies (EB), 1051 (37...
March 6, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29616366/de-escalation-of-breast-radiotherapy-after-conserving-surgery-in-low-risk-early-breast-cancer-patients
#15
REVIEW
Pierfrancesco Franco, Giuseppe Carlo Iorio, Sara Bartoncini, Mario Airoldi, Corrado De Sanctis, Isabella Castellano, Umberto Ricardi
The reduction in the burden related to treatment is becoming more and more important in modern oncology. Radiation therapy is a mainstay option in the postoperative setting for early breast cancer patients after breast-conserving surgery. Nowadays, different options are available to de-escalate radiotherapy in this scenario such as the use of hypofractionated whole-breast radiation, the selective delivery of the boost dose to the lumpectomy cavity, the introduction of accelerated partial breast irradiation and the omission of treatment in appropriately selected patients with low-risk features...
April 3, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29605247/breast-reconstruction-after-breast-conservation-therapy-for-breast-cancer
#16
Filip E F Thiessen, Wiebren A A Tjalma, Thierry Tondu
Conservative breast surgery followed by irradiation, often referred to as Breast conserving therapy (BCT), has replaced modified radical mastectomy for the treatment of early stage invasive breast cancer and ductal carcinoma in situ (DCIS). About 10% to 40% of the patients treated with BCT have poor cosmetic outcome results. Small tumours in large breasts can be successfully treated by lumpectomy and radiotherapy, with good cosmetic outcome. However when the tumour breast ratio is higher, the cosmetic outcome can be very disappointing...
March 27, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29595718/breast-cancer-following-augmentation-mammaplasty-a-case-control-study
#17
Michael Sosin, Chaitan Devulapalli, Charles Fehring, Edward R Hammond, Shawna C Willey, Eleni A Tousimis, Scott L Spear, Maurice Y Nahabedian, Elizabeth D Feldman
BACKGROUND: The purpose of this study was to determine whether augmentation mammaplasty, implant type, and implant location affect breast cancer detection, stage, and treatment. METHODS: An institutional case-control study was performed of patients with prior breast augmentation undergoing breast cancer treatment from 2000 to 2013. Controls were propensity matched and randomized, and data were retrospectively reviewed. RESULTS: Forty-eight cases and 302 controls were analyzed...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29594203/association-between-cumulative-radiation-dose-adverse-skin-reactions-and-changes-in-surface-hemoglobin-among-women-undergoing-breast-conserving-therapy
#18
Michael S Chin, Leah Siegel-Reamer, Gordon A FitzGerald, Allison Wyman, Nikole M Connor, Yuan-Chyuan Lo, Shirin Sioshansi, Janaki Moni, Maria Giulia Cicchetti, Janice F Lalikos, Thomas J FitzGerald
Introduction: Radiation therapy is crucial to effective cancer treatment. Modern treatment strategies have reduced possible skin injury, but few clinical studies have addressed the dose relationship between radiation exposure and skin reaction . This prospective clinical study analyzes skin oxygenation/perfusion in patients undergoing fractionated breast conserving therapy via hyperspectral imaging (HSI). Methods: Forty-three women undergoing breast conserving therapy were enrolled in this study...
June 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29582584/dysregulation-of-metabolic-associated-pathways-in-muscle-of-breast-cancer-patients-preclinical-evaluation-of-interleukin-15-targeting-fatigue
#19
Joseph Bohlen, Sarah L McLaughlin, Hannah Hazard-Jenkins, Aniello M Infante, Cortney Montgomery, Mary Davis, Emidio E Pistilli
BACKGROUND: Breast cancer patients report a perception of increased muscle fatigue, which can persist following surgery and standardized therapies. In a clinical experiment, we tested the hypothesis that pathways regulating skeletal muscle fatigue are down-regulated in skeletal muscle of breast cancer patients and that different muscle gene expression patterns exist between breast tumour subtypes. In a preclinical study, we tested the hypothesis that mammary tumour growth in mice induces skeletal muscle fatigue and that overexpression of the cytokine interleukin-15 (IL-15) can attenuate mammary tumour-induced muscle fatigue...
March 26, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29569502/tumor-size-in-breast-carcinoma-gross-measurement-is-important
#20
Ameer Hamza, Ramen Sakhi, Ahmed Alrajjal, Warda Ibrar, Shelby Miller, Sajad Salehi, Jacob Edens, Daniel Ockner
INTRODUCTION: The staging of breast carcinoma is mainly dependent on tumor size and lymph node status. Small increments in tumor size upstage the patient. An accurate determination of the tumor size is therefore critically important. Although the final staging is based on microscopic size, pathologists rely on gross measurements in a considerable number of cases. METHODS: We investigated the concordance between gross and microscopic measurements of breast carcinoma as well as factors affecting this concordance...
March 1, 2018: International Journal of Surgical Pathology
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