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Extramammary paget's disease

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https://www.readbyqxmd.com/read/28918854/erratum-to-extramammary-paget-s-disease-of-the-oral-mucosa-and-perioral-skin-oral-surg-oral-med-oral-pathol-oral-radiol-2017-124-2-e157-e163
#1
Xiangjian Wang, Lanyan Wu, Xueke Shi, Xin He, Wei Li, Hongmei Zhou
No abstract text is available yet for this article.
September 11, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28900484/chemokine-receptors-cxcr4-and-cxcr7-are-associated-with-tumor-aggressiveness-and-prognosis-in-extramammary-paget-disease
#2
Kun Chang, Gao-Xiang Li, Yun-Yi Kong, Xu-Xia Shen, Yuan-Yuan Qu, Zhong-Wei Jia, Yue Wang, Bo Dai, Ding-Wei Ye
Chemokines are involved in many aspects of oncogenesis, including regulation of cancer cell growth, dissemination and host-tumor response. However, the potential of the chemokine receptors, CXCR4 and CXCR7, in serving as biomarkers in extramammary Paget's disease (EMPD) has been rarely examined. Expressions of CXCR4 and CXCR7 were evaluated in 92 EMPD specimens by immunohistochemistry. High expression of CXCR4 and CXCR7 were both correlated with regional lymph node metastasis and presence of lymphovascular invasion...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28893632/patients-experiences-with-extramammary-paget-s-disease-an-online-pilot-study-querying-a-patient-support-group
#3
Paul H Chung, Jeremy T Kampp, Bryan B Voelzke
OBJECTIVE: To illustrate the heterogeneous care delivered to patients with Extramammary Paget's Disease (EMPD), a rare and lethal malignancy with poorly described treatment methodologies, by characterizing the clinical and pathological characteristics of an international patient support group. METHODS: Institutional review board approval was obtained to develop and distribute a non-validated survey to patients from an international, online EMPD support group. The survey was developed to capture patient clinical and pathological details and was distributed between January 2017 and February 2017...
September 8, 2017: Urology
https://www.readbyqxmd.com/read/28891079/successful-ts-1-monotherapy-as-the-second-line-treatment-for-advanced-extramammary-paget-s-disease-a-report-of-two-cases
#4
Junji Kato, Tokimasa Hida, Toshiharu Yamashita, Shiori Kamiya, Kohei Horimoto, Sayuri Sato, Hitomi Takahashi, Masahide Sawada, Mao Yamada, Hisashi Uhara
There is no standard chemotherapeutic treatment for advanced extramammary Paget's disease, though the effectiveness of some chemotherapy regimens, including docetaxel, has been reported. In this report, we report that TS-1 monotherapy was effective in two patients with advanced extramammary Paget's disease after docetaxel treatment failure. TS-1 monotherapy may be useful as the second-line treatment for patients with advanced extramammary Paget's disease.
September 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28887080/a-rare-case-of-metastatic-extramammary-paget-disease-of-the-spine-and-review-of-the-literature
#5
A Karim Ahmed, C Rory Goodwin, Nancy Abu-Bonsrah, Doreen Nguyen, Daniel M Sciubba
Extramammary Paget disease is an intraepithelial neoplasm affecting cells rich in apocrine glands-often located in the vulvar, scrotal, or perianal region. It typically affects older patients, between the ages of 50 and 80years old, and is most often limited to the epidermis. A 47-year-old Asian male first presented with enlargement of the right inguinal lymph node. A subsequent biopsy revealed extrammamary Paget disease of the scrotum. The patient eventually developed significant worsening back pain with bilateral lower extremity numbness and weakness three months later...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28846155/dermoscope-guided-lesional-biopsy-to-diagnose-ema-ck7-ck20-extramammary-paget-s-disease-with-an-extensive-lesion
#6
Antonio Chuh, Vijay Zawar, Regina Fölster-Holst
Dermoscopy has been reported to facilitate the diagnosis of extramammary Paget's disease (EMPD).(1-3) We report here the first application of dermoscope-guided lesional biopsy to confirm the diagnosis of EMPD. A 60-year-old male presented with a pruritic and painful rash over his left groin region for six months. This article is protected by copyright. All rights reserved.
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28827914/extramammary-paget-s-disease-of-the-perianal-region
#7
S Devaji Rao, Meera Govindarajan
Extramammary Paget's disease (EMPD) is uncommon and only a few cases have been reported in the literature. They are identical to the Mammary Paget's disease. This can occur where the apocrine glands are in abundance, more commonly in the genitalia and perianal area. We report here a case of Extramammary Paget's disease in the perianal region. The colourful background of this ulcer is analysed and the literature reviewed.
August 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28731239/new-technology-discloses-the-tumour-margin-of-extramammary-paget-disease
#8
N Hatta
No abstract text is available yet for this article.
July 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28712271/ectopic-extramammary-paget-s-disease-on-the-scalp
#9
Evgenia Balamonti, Eftychia Platsidaki, Anargyros Kouris, Akrivi Kostopoulou, Sofia Pappa, Georgios Kontochristopoulos
No abstract text is available yet for this article.
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28693610/gata3-is-a-sensitive-marker-for-primary-genital-extramammary-paget-disease-an-immunohistochemical-study-of-72-cases-with-comparison-to-gross-cystic-disease-fluid-protein-15
#10
Ming Zhao, Lixin Zhou, Li Sun, Yan Song, Yunquan Guo, Xun Zhang, Feng Zhao, Peng Wang, Junqiu Yue, Dongfeng Niu, Zhongwu Li, Xiaozheng Huang, Qiang Kang, Lin Jia, Jinping Lai, Dengfeng Cao
BACKGROUND: GATA-binding protein 3 (GATA3) has been identified as a sensitive marker for breast carcinoma but its sensitivity in primary genital extramammary Paget diseases (EMPDs) has not been well studied. METHODS: Here we investigated immunohistochemical expression of GATA3 in 72 primary genital EMPDs (35 from female, 37 from male; 45 with intraepithelial disease only, 26 with both intraepithelial disease and invasive adenocarcinoma including 14 also metastasis, 1 with metastatic adenocarcinoma only for study)...
July 10, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28653158/usefulness-of-mapping-biopsy-in-the-treatment-of-penoscrotal-extramammary-paget-s-disease
#11
Seong Oh Park, Jeong Hyun Ha, Ki Yong Hong, Hak Chang
BACKGROUND: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy; however, the standard treatment of EMPD has not been established. In this study, we applied mapping biopsy to penoscrotal EMPD and evaluated its effects. METHODS: A retrospective chart review was performed to determine the outcomes of patients with primary penoscrotal EMPD who underwent surgery at our institution between 2007 and 2014. Patients were divided into two groups (one group underwent mapping biopsy, while the other group did not), and the difference between the two groups was analyzed...
June 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28634665/usefulness-of-mapping-biopsy-in-the-treatment-of-penoscrotal-extramammary-paget-s-disease
#12
EDITORIAL
Curtis A Pettaway
No abstract text is available yet for this article.
June 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28631716/-anogenital-mammary-like-glands-and-related-diseases-part-2-malignant-tumors-of-the-anogenital-glands
#13
A M Konstantinova, I E Belousova, D Kacerovska, M Michal, K V Shelekhova, D V Kazakov
Mammary-like glands are a normal anatomical component of the anogenital region and can give rise to many benign and malignant tumors that morphologically mimic the similar diseases of the breast. The literature review is complemented by a description of 199 cases of malignant tumors of mammary-like glands. The paper presents the clinical and morphological characteristics of various malignant tumors of mammary-like glands, including extramammary Paget's disease, ductal, tubulolobular, adenoid cystic adenocarcinoma, low-grade phyllodes tumor, etc...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28614205/spectrum-of-changes-in-anogenital-mammary-like-glands-in-primary-extramammary-anogenital-paget-disease-and-their-possible-role-in-the-pathogenesis-of-the-disease
#14
Anastasia M Konstantinova, Dominic V Spagnolo, Colin J R Stewart, Denisa Kacerovska, Ksenya V Shelekhova, Jose A Plaza, Saul Suster, Jiri Bouda, Liubov Kyrpychova, Michal Michal, Irena E Belousova, Katrin Kerl, Dmitry V Kazakov
To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). In all cases, lesions involved the vulva and in 1 patient the perianal skin was affected. Histopathologically, AGMLG manifested changes identical to columnar cell change (CCC) (87...
August 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28611562/perianal-pagetoid-intraepithelial-carcinoma
#15
Suanga Sisodia, Robin Boushey, Goo Lee, Celia Marginean, Marcio M Gomes, Gaurav Bhattacharya, Kristopher Dennis
Extramammary Paget disease (EMPD) involving the perianal region is rare and challenging to manage. Primary EMPD involves stand-alone noninvasive lesions within the epidermis, while secondary EMPD involves phenotypically similar lesions derived from separate underlying malignancies. Differentiating between primary and secondary EMPD is challenging when no underlying malignancies are detected during workup. Continued reporting of perianal EMPD cases is encouraged so that risk stratification can be improved and patients can be managed with an appropriate level of aggressiveness...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28606832/extramammary-paget-s-disease-of-the-oral-mucosa-and-perioral-skin
#16
Xiangjian Wang, Lanyan Wu, Xueke Shi, Xin He, Wei Li, Hongmei Zhou
Extramammary Paget's disease (EMPD) is an unusual intraepidermal adenocarcinoma. Only 2 cases of EMPD in the oral mucosa have been reported previously. Here, we present the first report of a rare case of Paget's disease of the oral mucosa and perioral skin with extensive contiguous erythematous and erosive manifestations. Ultimately, the patient was treated with oral thalidomide for 8 weeks. We noticed an improvement with resolution of symptoms. A 3-year follow-up showed no relapse. Thus, this case may provide new insights to clinicians about treatment of EMPD...
May 11, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28603180/intratumor-dihydropyrimidine-dehydrogenase-mrna-expression-levels-are-decreased-in-extramammary-paget-s-disease
#17
Yuki Nakamura, Ikko Kajihara, Yamada-Kanazawa Saori, Maeda-Otsuka Saki, Takamitsu Johno, Jun Aoi, Toshikatsu Igata, Shinichi Masuguchi, Satoshi Fukushima, Masatoshi Jinnin, Hironobu Ihn
S-1, a 5-fluorouracil (5-FU)-based anti-cancer agent, is an important drug for treating metastatic extramammary Paget's disease (EMPD). Although intratumor expression levels of 5-FU metabolism enzymes have been studied widely in many solid tumors, no studies have examined on the expression levels of thymidylate synthase (TS), orotate phosphoribosyl-transferase (OPRT) or dihydropyrimidine dehydrogenase (DPD) in skin cancers. The aim of this study was to estimate the intratumoral mRNA expression levels of these genes in EMPD by real time PCR...
June 11, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28582341/invasive-extramammary-paget-disease-of-the-vulva-with-signet-ring-cell-morphology-in-a-patient-with-signet-ring-cell-carcinoma-of-the-stomach-report-of-a-case
#18
Byung-Kwan Jeong, Kyu-Rae Kim
This report describes a rare case of invasive extramammary Paget disease of the vulva with signet ring cell morphology in a 58-yr-old woman with a history of signet ring cell carcinoma of the stomach. This case was initially misinterpreted as a metastatic gastric carcinoma to the vulva because an initial small, superficial biopsy specimen showed infiltration of signet ring cells in the dermis without intraepidermal Paget cells. However, a surgically resected specimen showed concordant immunophenotypes in both intraepidermal Paget cells and intradermal signet ring cell components with immunoreactivity to cytokeratin (CK) 7, CEA, and gross cystic disease fluid protein-15, and immunonegativity for CK20, MUC5AC, and MUC6...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28543532/intraepidermal-merkel-cell-carcinoma-a-case-series-of-a-rare-entity-with-clinical-follow-up
#19
George Jour, Phyu P Aung, Eduardo Rozas-Muñoz, Johnathan L Curry, Victor Prieto, Doina Ivan
BACKGROUND: Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous carcinoma. MCC involves typically dermis and although epidermotropism has been reported, MCC strictly intraepidermal or in situ (MCCIS) is exceedingly rare. Most of the cases of MCCIS described so far have associated other lesions, such as squamous or basal cell carcinoma, actinic keratosis and so on. Herein, we describe 3 patients with MCC strictly in situ, without a dermal component. METHODS: Our patients were elderly, 2 of the lesions involved the head and neck area and 1 was on a finger...
May 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28525420/diagnostic-criteria-in-intraepithelial-pagetoid-neoplasms-a-histopathologic-study-and-evaluation-of-select-features-in-paget-disease-bowen-disease-and-melanoma-in-situ
#20
Amira Elbendary, Ruzeng Xue, Manuel Valdebran, Kara Melissa T Torres, Kruti Parikh, Inas Elattar, Eun Ji Kwon, Dirk M Elston
BACKGROUND: Paget disease, Bowen disease, and malignant melanoma in situ are intraepidermal neoplasms, characterized by the presence of pagetoid scatter of atypical cells in the epidermis. This study reviewed the frequency of select histologic criteria to validate their usefulness in the histologic distinction between these entities. METHODS: One hundred forty-four specimens with the diagnosis of Bowen disease, 144 specimens with Paget disease (mammary and extramammary), and 144 specimens with malignant melanoma in situ were examined microscopically to define frequencies of select histologic criteria present in each disease...
June 2017: American Journal of Dermatopathology
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