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Extramammary paget's disease

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https://www.readbyqxmd.com/read/28058078/extramammary-paget-s-disease-of-anal-canal-associated-with-rectal-adenoma-without-invasive-carcinoma
#1
Vaibhav Chumbalkar, Timothy A Jennings, Sanaz Ainechi, Edward C Lee, Hwajeong Lee
Extramammary Paget's disease (EMPD) is a rare disease which is found in apocrine-rich locations such as anogenital region, axilla and rarely in other sites. Perianal EMPD is often reported as the involvement of perianal skin, but involvement of anal mucosa is very rare. Based on pathogenesis and association with either synchronous or metachronous malignancy, EMPD can be divided into primary and secondary types. Treatment approach for these two types of Paget's disease and their prognosis is different, thus it is important to make the distinction...
December 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/28052404/perineal-reconstruction-with-multiple-perforator-flaps-based-on-anatomical-divisions
#2
Joon P Hong, Chang G Kim, Hyun S Suh, Hoon Kim, Chi S Yoon, Kyu N Kim
PURPOSE: Reconstruction of perineal defects remains a challenge because such defects can be extensive, complex, and three-dimensional. This report presents a retrospective review of our past 5 years of experience in perineal reconstruction, and suggests a simple algorithmic approach according to anatomical divisions with multiple pedicled perforator flaps for extensive perineal defects. METHODS: From January 2011 to December 2015, 16 patients, including 5 men and 11 women, underwent reconstruction of extensive perineal defects...
January 4, 2017: Microsurgery
https://www.readbyqxmd.com/read/28028810/three-dimensional-evaluation-of-subclinical-extension-of-extramammary-paget-s-disease-visualization-of-histological-border-and-its-comparison-to-clinical-border
#3
T Murata, T Honda, G Egawa, A Kitoh, T Dainichi, A Otsuka, S Nakajima, S Kore-Eda, Y Kaku, S Nakamizo, Y Endo, A Fujisawa, Y Miyachi, K Kabashima
BACKGROUND: In extramammary Paget's disease (EMPD), Paget cells are sometimes detected outside the clinical border (subclinical extension). The spreading pattern of Paget cells in subclinical extension, however, remains unclear. In addition, the macroscopic appearances of lesions accompanied by subclinical extension are totally unknown. OBJECTIVES: To characterize the spreading pattern of Paget cells as well as the macroscopic appearance of lesions of EMPD with subclinical extension...
December 27, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27994832/mayo-clinic-cancer-center-experience-of-metastatic-extramammary-paget-disease-1998-2012
#4
Leslie Padrnos, Nina Karlin, Thorvardur R Halfdanarson
Extramammary Paget disease (EMPD) is a rare cutaneous malignancy. The most common presentation of EMPD is the vulva followed by perianal involvement. Most cases are localized to the dermis with treatment focused on surgery, topical treatment or radiotherapy. Recurrence is frequent despite therapies utilized. Metastatic extramammary Paget disease is uncommon and, as such, standard treatment guidelines do not exist. This study sought to evaluate the treatment regimens and outcomes of patients treated at a Mayo Clinic Center from 1998-2012...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27976423/mohs-micrographic-surgery-of-rare-cutaneous-tumors
#5
Sophie C Flohil, Charlotte B van Lee, Jessica Beisenherz, Marc A M Mureau, Lucy I H Overbeek, Tamar Nijsten, Renate R van den Bos
BACKGROUND: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumors are poorly defined. OBJECTIVE: Investigate the recurrence rate after MMS for rare cutaneous tumors at a university center. METHODS & MATERIALS: Retrospective review of all rare cutaneous tumors treated with MMS at a large university center between January 2008 and December 2012. To detect all recurrences, patients were linked to The nationwide network and registry of histo- and cytopathology (PALGA)...
December 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27832673/extramammary-paget-disease-of-the-vulva-case-report
#6
Bianca Ruschel Hillmann, Amanda Amaro Pereira, Luiz Fernando Sommacal
Extramammary Paget disease (EPD) is a rare malign neoplasm that may affect the vulva and has manifestations common to benign diseases such as itching, pain and eczema. This leads to delay in diagnosis and consequent worse prognosis. The definitive diagnosis is obtained by biopsy of the vulva, which shows Paget cells. The treatment of choice is wide excision with margins, which leads to sequelae, functional and aesthetic. Recurrence is common. This article reports the case of a 48-year-old female patient with history of vulvar itching for the past 2 years, who had been submitted to various treatments for benign pathologies...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27772880/primary-invasive-extramammary-paget-s-disease-on-penoscrotum-a-clinicopathological-analysis-of-41-cases
#7
Yunyi Kong, Xuxia Shen, Jiaojie Lv, Bo Shu
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27761174/spinal-metastases-of-extramammary-paget-disease-with-radiologic-pathologic-correlation
#8
Jason T Little, Vance T Lehman, Jonathan M Morris, Julia S Lehman, Felix E Diehn
Extramammary Paget disease (EMPD) is an uncommon malignancy. It manifests either in the primary form in the skin as an intraepithelial neoplasm, or in secondary form as pagetoid (intraepithelial) spread of an underlying internal carcinoma to the skin. Although local invasion and recurrence of primary extramammary Paget disease are relatively frequent, widespread metastases are rare. As such, there are very few reports and little characterization of the radiologic features of widespread spinal metastases. To our knowledge, there are no prior reports of a metastatic extramammary Paget disease presenting as a painful pathologic vertebral body compression fracture...
May 2016: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/27746643/perianal-and-vulvar-extramammary-paget-disease-a-report-of-six-cases-and-mapping-biopsy-of-the-anal-canal
#9
Yuzo Nagai, Sinsuke Kazama, Daisuke Yamada, Takuya Miyagawa, Koji Murono, Koji Yasuda, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Yuri Masui, Hiroaki Nozawa, Hironori Yamaguchi, Soichiro Ishihara, Takafumi Kadono, Toshiaki Watanabe
Treatment of perianal and vulvar extramammary Paget disease (EMPD), rare intraepithelial malignancies, is often challenging because of its potential to spread into the anal canal. However, there is still no consensus regarding the optimal resection margin within the anal canal. Between 2004 and 2014, six patients (three with perianal EMPD and three with vulvar EMPD) in which the spread of Paget cells into the anal canal was highly suspected were referred to our department. To evaluate the disease extent within the anal canal, preoperative mapping biopsy of the anal canal was performed in five out of six patients...
October 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27717438/preneoplastic-and-primary-scrotal-cancer-updates-on-pathogenesis-and-diagnostic-evaluation
#10
REVIEW
Yao Zhu, Ding-Wei Ye
Occupational exposure has been causally linked to scrotal cancer. Primary preventative care and avoiding carcinogenic substances have decreased the incidence and changed the treatment of scrotal cancer. The current incidence of scrotal malignancy is approximately 1 per 1,000,000 male persons/year. The rarity of cases and of research impedes our understanding of the changing nature of scrotal cancer. This article summarizes the current knowledge, focusing mainly on pathogenesis and diagnostic evaluation, which may influence prevention and early recognition of the disease...
November 2016: Urologic Clinics of North America
https://www.readbyqxmd.com/read/27689055/three-directional-reconstruction-of-a-massive-perineal-defect-after-wide-local-excision-of-extramammary-paget-s-disease
#11
Seung Woo Cho, Hak Chang, Sung Tack Kwon
Extramammary Paget's disease (EMPD) is a rare, slow-growing intraepithelial malignancy that mainly involves the genital region, including the vulva, penis, scrotum, perianal, and periurethral areas. Although several treatment options exist, wide local excision with a safe margin is considered the treatment of choice. After resection of the lesion, it is often challenging to reconstruct the defect because defects in the perineal region require adequate volume for protection and are susceptible to infections, which is a particularly significant risk for large defects...
September 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27686876/chemotherapy-reaction-induced-by-ixabepilone-a-microtubule-stabilizing-agent-mimicking-extramammary-paget-s-disease-in-a-patient-with-breast-carcinoma
#12
Jillian W Millsop, Victoria R Sharon, Tatyana Petukhova, Maxwell A Fung, Maija Kiuru
The histopathologic characteristics of reactions caused by the many novel anticancer agents are under-recognized. We report a case of a 67-year-old female with locally advanced metastatic breast cancer, who initially presented with an extensive reticulated erythematous patch on the trunk caused by intravascular metastases confirmed by a skin biopsy. Owing to disease progression, she was started on ixabepilone, a mitotic inhibitor. While receiving ixabepilone, another skin biopsy was obtained and initially interpreted as extramammary Paget's disease...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27661427/intraepithelial-extramammary-paget-s-disease-of-the-vulva-the-clinicopathological-characteristics-management-and-outcome-in-a-study-of-18-female-patients
#13
Lingling Fan, Jin Zhu, Xiang Tao, Congjian Xu
OBJECTIVE: This study aimed to analyze the clinicopathologic characteristics, management, and outcome of patients with intraepithelial extramammary Paget's disease of the vulva (EMPDV). MATERIALS AND METHODS: This retrospective study included medical records and pathological slides of 18 female patients with EMPDV between January 2001 and December 2012. Diagnosis was confirmed using conventional hematoxylin and eosin staining. RESULTS: The median age was 65 years...
October 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27633145/gata3-expression-in-primary-vulvar-paget-disease-a-potential-pitfall-leading-to-misdiagnosis-of-pagetoid-urothelial-intraepithelial-neoplasia
#14
Diogo Morbeck, Aline C Tregnago, Glauco Baiocchi Netto, Carlos Sacomani, Patricia M Peresi, Cynthia T Osório, Luciana Schutz, Stephania M Bezerra, Louise de Brot, Isabela W Cunha
AIMS: GATA3 has been reported as a specific urothelial marker among organs in the pelvic region, and has been classified as highly sensitive and specific for urothelial and breast carcinomas. Our aim was to verify GATA3 expression in extramammary Paget disease, and to determine whether it can be use to differentiate primary vulvar Paget disease from pagetoid urothelial intraepithelial neoplasia (PUIN). We also analysed HER2 protein expression and HER2 gene amplification and their roles as prognostic factors in extramammary Paget disease...
February 2017: Histopathology
https://www.readbyqxmd.com/read/27628645/multiorgan-involvement-of-extramammary-paget-s-disease-with-mucinous-carcinoma-like-components
#15
Ryoko Kimura, Yuichi Yoshida, Tatsushi Shiomi, Shigeto Yanagihara, Reiko Tsutsumi, Kazunari Sugita, Osamu Yamamoto
No abstract text is available yet for this article.
December 1, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27587306/extramammary-paget-s-disease-of-the-oral-tissues-literature-review-and-a-rare-case-report
#16
Hana Kennedy, Jayanth Kunjur, Kavita Amarasinghe, Graham Smith
Extramammary Paget's disease (EMPD) is a rare, cutaneous adenocarcinoma in situ characterized by a chronic eczema-like rash of the anogenital regions. It is usually slow growing, locally invasive and presents mainly with pruritis. Extremely rare in the oral tissues, here we present a case of EMPD of the hard palate and a review of the existing literature base.
2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27566212/ante-mortem-diagnosis-of-pulmonary-tumour-thrombotic-microangiopathy-in-a-patient-with-unrecognised-extramammary-paget-s-disease
#17
Aya Banno, Keijiro Chiba, Hiroko Kasai, Keiichi Nagami
Pulmonary tumour thrombotic microangiopathy (PTTM) resulting in fatal pulmonary hypertension is a rare complication of malignancy. Patients with PTTM generally suffer rapid deterioration of hypoxaemia, and a diagnosis is often only made at autopsy. We report a case of extramammary Paget's disease associated with PTTM. An ante-mortem diagnosis was made based on cytology of blood aspirated from a pulmonary artery catheter in a wedged position. Together with a review of the literature, this case highlights the potential diagnostic value of blood cytology in patients with cancer with rapidly progressing pulmonary hypertension...
August 26, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27544564/management-of-extramammary-paget-s-disease-with-a-staged-modified-mohs-technique
#18
Anant Shukla, Matthew Stringer, Pansy Uberoi, Steven Hudak, George Kallingal
Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma arising from apocrine glands. We describe an innovative surgical technique to manage extensive cutaneous malignancies in a notoriously challenging location. The patient is a 78-year-old male who presented with 'jock itch' on his left groin refractory to topical treatment. A shave biopsy of the lesion demonstrated non-invasive EMPD which yielded a urology consult. Rather than the standard wide local excision (WLE), which can lead to positive margins, progression, and recurrence, we used a modified the Mohs technique and staged the procedure, providing excellent oncologic and cosmetic outcomes...
August 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/27526657/topical-imiquimod-in-the-treatment-of-extramammary-paget-s-disease-a-10-year-retrospective-analysis-in-an-asian-tertiary-centre
#19
MeiQi May Liau, Shiyao Sam Yang, Kong Bing Tan, Chen Wee Derrick Aw
Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma usually found in apocrine-rich areas. Although surgery remains standard treatment, topical imiquimod has emerged as a promising drug for the treatment of EMPD in recent years. We present our experience in treating EMPD in Asian skin successfully with topical imiquimod 5% cream, over the past 10 years in our tertiary institution.
November 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27511910/extramammary-paget-disease-of-the-perianal-region-the-potential-role-of-imiquimod-in-achieving-disease-control
#20
Stephen R Knight, Charlotte Proby, Dorin Ziyaie, Frank Carey, Sacha Koch
Extramammary Paget disease (EMPD) is a rare perineal neoplasia associated with a high rate of local recurrence. Surgical excision is the standard treatment; however, this has high rates of post-operative morbidity in combination with potentially mutilating results. Previous literature has demonstrated good response with imiquimod 5% cream in patients with vulval EMPD, yet its effectiveness in primary perianal disease is unknown.We describe the case of a 40-year-old woman presenting with EMPD of the perianal region, providing detailed histological and pictoral evidence of its response to topical imiquimod 5% cream over a 16-week period, which initially resulted in remission prior to metastatic lymph node recurrence...
2016: Journal of Surgical Case Reports
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