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Extramammary paget's disease

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https://www.readbyqxmd.com/read/29324542/extramammary-paget-disease-of-the-vulva-a-case-series-examining-treatment-recurrence-and-malignant-transformation
#1
Roni Nitecki, Michelle Davis, Jaclyn C Watkins, Yiru E Wu, Allison F Vitonis, Michael G Muto, Ross S Berkowitz, Neil S Horowitz, Colleen M Feltmate
OBJECTIVES: Extramammary Paget disease (EMPD) of the vulva is a rare lesion with a high recurrence rate ranging from 12% to 61%. The rate of underlying adenocarcinoma varies, but in the largest series was reported at 4%. Given the rarity of the disease there is a paucity of data to optimize treatment. This study aims to describe the management and recurrence patterns in a tertiary care setting and to offer suggestions for management in a modern-day setting. METHODS: Patients with pathologically confirmed EMPD treated from 2000 to 2015 were retrospectively identified using an IRB approved database...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29319287/double-extramammary-paget-s-disease
#2
Massimiliano Scalvenzi, Milena Cappello, Daniela Russo, Massimo Mascolo, Giuseppe Monfrecola, Claudia Costa
No abstract text is available yet for this article.
February 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29311042/fatal-venous-embolism-in-a-patient-with-advanced-extramammary-paget-disease
#3
Hiroyuki Goto, Kazunari Sugita, Yuichi Yoshida, Osamu Yamamoto
No abstract text is available yet for this article.
December 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29277763/the-expression-of-matrix-metalloproteinases-in-receptor-activator-of-nuclear-factor-kappa-b-ligand-rankl-expressing-cancer-of-apocrine-origin
#4
Yumi Kambayashi, Taku Fujimura, Sadanori Furudate, Chunbing Lyu, Takanori Hidaka, Aya Kakizaki, Yota Sato, Kayo Tanita, Setsuya Aiba
Primary cutaneous apocrine carcinoma (PCAC) is a rare and highly aggressive tumor entity. Since there is no conventional therapy for advanced PCAC, exploratory treatments are sometimes used. As we previously reported, receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL)/RANK signaling on M2 macrophages promotes the production of chemokines and proinflammatory cytokines to maintain the immunosuppressive tumor environment of extramammary Paget's disease (EMPD). Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK+ M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277730/evaluation-of-mapping-biopsies-for-extramammary-paget-s-disease-a-retrospective-study
#5
Yumiko Kaku-Ito, Takamichi Ito, Gaku Tsuji, Takeshi Nakahara, Akihito Hagihara, Masutaka Furue, Hiroshi Uchi
BACKGROUND: Extramammary Paget's disease (EMPD) sometimes shows an ill-defined border and an unexpectedly extended tumor spread beyond the clinical borders. Mapping biopsy is one approach for complete surgical removal, but its efficacy has remained controversial. OBJECTIVE: We sought to evaluate the mapping biopsy for EMPD. METHODS: We performed a retrospective review of 133 patients with 150 primary EMPD lesions. We histopathologically examined 1182 skin biopsy specimens (975 from mapping biopsy and 207 from lesional biopsy)...
December 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29250682/extramammary-paget-s-disease-in-an-hiv-positive-patient
#6
Constantin Căruntu, Sabina Andrada Zurac, GheorghiŢă Jugulete, Daniel Boda
Extramammary Paget's disease (EMPD) is an uncommon intraepithelial carcinoma usually found as an irregular, pruritic plaque on the apocrine-rich anogenital skin. Diagnosis of EMPD is challenging due to the rarity of the disease and the uncharacteristic clinical aspect and requires histopathological confirmation. We report the case of a 62-year-old human immunodeficiency virus (HIV)-positive male, which presents with a lesion of the left part of pubic area with clinical and dermatoscopic appearance suggestive for Bowen's disease but with histopathological diagnosis of EMPD...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29250514/perianal-paget-disease-a-report-of-2-cases
#7
Youn Young Park, Moonsik Kim, Chinock Cheong, Sang Kyum Kim, Seung Yong Song, Kee-Yang Chung, Nam Kyu Kim
Extramammary Paget disease (EMPD) is a rare cutaneous neoplasm. Perianal Paget disease (PPD) is a subset of EMPD manifesting perianal lesions. Two cases of PPD in Severance Hospital are described in this article. A 65-year-old female and 78-year-old male patients visited our institution because of an unhealed perianal skin lesion despite treatment for a long period with topical agents. PPD was diagnosed by skin biopsies in both cases, and the patients underwent surgical treatment. Clinical manifestations, preoperative work-ups, and surgical treatments including different reconstruction methods are described in detail...
December 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29214113/reflectance-confocal-microscopy-of-mammary-paget-disease
#8
Fezal Ozdemir, Bengu G Turk, Banu Yaman, Giovanni Pellecani, Necmettin Ozdemir, Isil Karaarslan, Francesca Farnetani
Mammary Paget disease is the intraepidermal adenocarcinoma of the nipple area which is characterized usually by a well-demarcated eczematous plaque. Reflectance confocal microscopy (RCM), is an in vivo noninvasive diagnostic tool with a high-resolution imaging of the skin, almost comparable to conventional histology. RCM findings of Paget disease are limited in the literature. Most of the reported cases are the extramammary type. In this report, we aimed to evaluate the RCM findings of a non-pigmented mammary Paget disease in a 65 year-old woman...
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29203997/perianal-paget-s-disease-a-case-report-and-a-review-of-current-diagnosis-and-management
#9
Chintamani Godbole, Jyoti Mehta, Bijoy Methil, Reshma Palep, Prajesh Bhuta
Paget's disease is an intraepithelial adenocarcinoma arising from the apocrine gland component of the skin. Paget's disease is most common in the breast but extra mammary disease is also seen. Perianal Paget's disease is a rare form of extramammary disease with few cases reported in literature. It can be primary-arising from the skin or secondary-cutaneous metastases of anorectal or genitourinary malignancy. We hereby wish to report a case of perianal Paget's disease that presented as an eczematous lesion and was diagnosed incidentally on biopsy...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29202553/extramammary-paget-s-disease-associated-with-genital-wart-and-lichen-sclerosus
#10
Rana Rafiei, Hojat Eftekhari, Siamak Granmayeh, Nahid Nickhah, Behnam Rafiee
Extramammary Paget's disease is an uncommon intraepithelial adenocarcinoma in genital and perianal regions. Genital wart is the most common sexually transmitted disease caused by human papilloma viruses and vulval lichen sclerosus is chronic pruritic dermatitis in genital area which could be able to change to invasive squamous cell carcinoma. We report a patient who had simultaneous lichen sclerosus, genital wart and extramammary Paget's disease of the vulva. We could not find any significant association between them in literature...
September 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29181166/successful-and-long-term-response-to-trastuzumab-plus-paclitaxel-combination-therapy-in-human-epidermal-growth-factor-receptor-2-positive-extramammary-paget-s-disease-a-case-report-and-review-of-the-literature
#11
Takashi Ichiyama, Daisuke Gomi, Toshirou Fukushima, Takashi Kobayashi, Nodoka Sekiguchi, Akiyuki Sakamoto, Shigeru Sasaki, Keiko Mamiya, Tomonobu Koizumi, Yoshihisa Hama
A 58-year-old woman with a histologically confirmed diagnosis of vulvar extramammary Paget's disease (EMPD) was referred to our hospital due to locally advanced and relapsed EMPD. The patient had undergone surgical resection three times for relapsed vulvar EMPD over a period of 12 years, but developed locally advanced and unresectable EMPD. As pathological examination indicated that the lesion was positive for human epidermal growth factor receptor 2 (HER2) on immunohistochemical staining, the patient was treated with trastuzumab plus paclitaxel...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29115681/imiquimod-5-cream-as-a-therapeutic-option-for-extramammary-paget-s-disease
#12
Masahide Sawada, Junji Kato, Toshiharu Yamashita, Akihiro Yoneta, Tokimasa Hida, Kohei Horimoto, Sayuri Sato, Hisashi Uhara
A wide local excision is the standard treatment for extramammary Paget's disease (EMPD), though this treatment often leads to permanent anogenital mutilation and functional impairment. The purpose of our study is to evaluate the efficacy and safety of the topical application of imiquimod 5% cream for non-invasive EMPD. We examined nine patients with EMPD. Eight of the nine patients were treated with imiquimod 5% cream three times per week for 16 weeks; one case was treated for 6 weeks. The response rate was 100% including five complete remissions...
November 8, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29113769/advanced-scrotal-extramammary-paget-s-disease-treated-with-apatinib-a-case-report
#13
Yun-Ni Zhang, Ye Chen, Feng Gao, Ni Chen, Ji-Yan Liu
No abstract text is available yet for this article.
October 16, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29082243/mammary-and-extramammary-paget-s-disease-presented-different-expression-pattern-of-steroid-hormone-receptors
#14
Songxia Zhou, Weixiang Zhong, Ruiqin Mai, Guohong Zhang
BACKGROUND AND OBJECTIVES: Paget's disease (PD) is a rare intraepithelial adenocarcinoma, which is composed of mammary (MPD) and extramammary Paget's disease (EMPD). Currently, the published literature contains scant data on expression pattern of steroid hormone receptors in MPD and EMPD. METHODS: Expression of estrogen receptor (ER) and androgen receptor (AR) was evaluated in 88 MPD and 72 EMPD by using immunohistochemical staining and H-score method. RESULTS: Positive expression of AR was significantly higher in EMPD (61...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29079166/benefits-of-urologic-dermatologic-consultations-for-the-diagnosis-of-cutaneous-penile-lesions-a%C3%A2-prospective-study
#15
Edouard Fortier, Arnaud Cerruti, Christian Le Clec'h, Abdel-Rahmène Azzouzi, Pierre Bigot
INTRODUCTION: We evaluated the benefits of a specialized consultation created in 2014 for cutaneous penile lesions. MATERIALS AND METHODS: We performed a descriptive prospective study evaluating all patients sent for a monthly urologic-dermatologic consultation at a French university hospital from September 2014 to September 2015 for cutaneous penile lesions. All patients evaluated were included. We collected the demographic data, clinical examination findings, and the proposed diagnosis and treatment for every patient...
October 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29054795/topical-ala-pdt-as-alternative-therapeutic-option-in-treatment-recalcitrant-dermatosis-report-of-4-cases
#16
REVIEW
Calvina Theresia, Jie Zheng, Xiao-Ying Chen
BACKGROUND: Topical Photodynamic therapy (PDT) is widely acknowledged for its safety and effectiveness in treating oncologic skin diseases such as basal cell carcinoma, actinic keratosis and squamous cell carcinoma in situ. Despite its broad applications in dermatology, this method is a relatively new therapeutic option for treating inflammatory/infectious skin diseases. OBJECTIVES: To determine whether topical PDT is a safe and effective treatment option in treating treatment-recalcitrant dermatosis...
October 17, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29033402/5-aminolevulinic-acid-5-ala-fluorescence-guided-mohs-surgery-resection-of-penile-scrotal-extramammary-paget-s-disease
#17
Xiaoqiong Peng, Wei Qian, Jiangang Hou
This report aims to evaluate the usefulness of 5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease for achieving maximum tumor resection. Between January 2014 and December 2015, 5 patients underwent surgical resection of a penile-scrotal extramammary Paget's disease in department of urology, Huashan hospital, Fudan University. All patients were coated with 5-ALA (concentration of 20%) throughout the scrotum and the visible range of the lesion plus a 2cm margin 3 hours before the induction of anesthesia...
October 16, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28992669/-a-case-of-secondary-extramammary-paget-s-disease-aroundthe-cutaneous-stoma-after-radical-cystectomy
#18
Sohei Kanda, Kazutoshi Okubo, Takuya Hida, Jin Kono, Takeshi Takahashi, Kenji Mitsumori, Toshihide Shimada, Kazuo Nishimura
We present a case of secondary extramammary Paget's disease around the cutaneous ureterostomy stoma after radical cystectomy. An 85-year-old man with bacillus calmette-guérin refractory high-grade urothelial carcinoma underwent radical cystectomy and cutaneous ureterostomy construction. After right ureter cancer diagnosis, he underwent right nephroureterectomy 3 years after the cystectomy. He developed refractory dermatitis around the cutaneous stoma 1 year after the nephroureterectomy. Skin biopsy revealed secondary extramammary Paget's disease, cured by skin excision around the cutaneous stoma and skin grafting...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28976448/invasive-paget-disease-of-the-vulva
#19
Chiara Borghi, Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Cono Scaffa, Stefania Perotto, Umberto Leone Roberti Maggiore, Dario Recalcati, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Extramammary Paget disease of the vulva (EPDV) is a rare occurrence with an indolent and relapsing course. Progression to invasion occurs in 4% to 19% of cases. The aim of this study is to report clinical-pathological features and outcomes of patients treated for invasive EPDV. METHODS: Data of consecutive patients treated between 2000 and 2017 for invasive EPDV were reviewed. RESULTS: Among 79 patients with EPDV, 10 (12.7%) presented a microinvasive or invasive form at first diagnosis or during follow-up...
October 3, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28945622/clinical-benefits-of-preoperative-conventional-fluorescence-diagnosis-in-surgical-treatment-of-extramammary-paget-disease
#20
Miaojian Wan, Han Ma, Yue Zhao, Lin Xie, Zhirui Chen
BACKGROUND: In extramammary Paget disease (EMPD), initial margins of surgical excision are difficult to determine preoperatively. Fluorescence diagnosis (FD) may have utility as a noninvasive method for delineating tumor boundaries. OBJECTIVE: The relationship between FD-delineated borders and results of multiple scouting biopsies (MSBs) in EMPD was investigated, evaluating the potential clinical role of FD. MATERIALS AND METHODS: A cohort of 21 patients was studied, looking for consistencies between FD and MSB results...
September 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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