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Porokeratosis

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https://www.readbyqxmd.com/read/29341221/pediatric-penile-porokeratosis-a-case-report
#1
Omar Bari, Antoanella Calame, Sarah Marietti-Shepherd, Victoria R Barrio
We present what we believe to be the second case of pediatric penile porokeratosis and the youngest case reported. A 6-year-old boy presented with a pruritic, verrucous growth at the urethral meatus that recurred after two meatotomies. The diagnosis of porokeratosis was confirmed by biopsy. Porokeratosis should be added to the differential diagnosis of chronic hyperkeratotic penile lesions in children.
January 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29232434/linear-porokeratosis-associated-with-multiple-squamous-cell-carcinomas
#2
Blake Friedman, Kseniya Golubets, Jonhan Ho, Timothy Patton
Linear porokeratosis is a rare subtype of porokeratosis with a higher rate of malignant transformation than other subtypes of porokeratosis. Identification of cornoid lamellae on histology allows for definitive diagnosis, which makes high clinical suspicion and appropriate biopsy essential in establishing the correct diagnosis and developing an effective management plan. We present a case report of linear porokeratosis and discuss aspects of etiology, diagnosis, and management.
November 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29221722/ink-enhanced-dermoscopy-is-a-useful-tool-to-differentiate-acquired-solitary-plaque-porokeratosis-from-other-scaly-lesions
#3
Cristián Navarrete-Dechent, Pablo Uribe, Ashfaq Marghoob
No abstract text is available yet for this article.
December 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29221608/a-case-of-eruptive-disseminated-porokeratosis-in-a-cancer-patient-after-trastuzumab-and-exemestane-treatment-cancer-related-or-drug-induced-phenomenon
#4
C Mangas, V Espeli, R Blum
No abstract text is available yet for this article.
December 5, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29194784/inflammatory-disseminated-superficial-porokeratosis-successfully-controlled-with-a-combination-of-topical-diclofenac-gel-and-systemic-etretinate
#5
Satoko Shimizu, Yuka Takashima, Moeko Hotta, Eri Ito, Reine Moriuchi
Porokeratosis is an uncommon keratinization disorder characterized clinically by annular keratotic plaques and histologically by cornoid lamella, a vertical stack of parakeratotic corneocytes within the horny layer. Disseminated superficial porokeratosis (DSP) manifests with several to hundreds of small annular lesions on sun-exposed and non-sun-exposed body areas [1]. Recently, unusual cases of DSP accompanied by severe pruritus and inflammation have been reported as inflammatory DSP [2, 3]. Here, we report a case of inflammatory DSP successfully controlled with topical diclofenac gel and oral etretinate...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29159004/linear-malignant-melanoma-in-situ-reports-and-review-of-cutaneous-malignancies-presenting-as-linear-skin-cancer
#6
Philip R Cohen
Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. A medical literature search engine, PubMed, was used to search the following terms: cancer, cutaneous, in situ, linear, malignant, malignant melanoma, melanoma in situ, neoplasm, and skin...
September 18, 2017: Curēus
https://www.readbyqxmd.com/read/28976625/amelanotic-melanoma-arising-within-a-lesion-of-disseminated-superficial-actinic-porokeratosis-an-unusual-presentation-leading-to-a-novel-therapeutic-approach
#7
Ali Al-Haseni, Pooja Chitgopeker, Jonathan D Ho, Lynne J Goldberg, Debjani Sahni
Disseminated superficial actinic porokeratosis (DSAP) is the most common variant of porokeratosis with a potential for malignant transformation. Its association with malignant melanoma, however, is exceedingly rare. Treatment of DSAP is often ineffective. We report a unique case of amelanotic melanoma arising within a lesion of DSAP. The melanoma was managed surgically, and her DSAP were treated successfully with a novel approach utilizing 5-fluorouracil chemowraps.
October 4, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28940636/porokeratosis-ptychotropica-a-diagnostic-and-therapeutic-challenge
#8
Jose Contreras-Ruiz, Sonia Toussaint-Caire, Paula Torres-Camacho, Virginia Berenice Villa-Castro
The porokeratoses are characterized by the formation of cornoid lamellae. Porokeratosis ptychotropica (PP), is a rare form first described by Lucker, where the dyskeratotic skin changes are mainly located around the gluteal cleft or genital area (1, 2). A 56-year-old man presented with mildly pruritic symmetrical hyperkeratotic brown plaques with subtle fine scaling, and smaller satellite plaques, affecting both buttocks, and partially the intergluteal cleft. (Figure 1 a) The plaque began a year before on the right buttock, and a second plaque followed on the left...
September 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28922948/clinical-and-dermoscopic-features-of-pigmented-disseminated-superficial-actinic-porokeratosis-case-report-and-literature-review
#9
Bahman Sotoodian, Muhammad N Mahmood, Thomas G Salopek
INTRODUCTION: Porokeratosis is a benign hyperkeratotic skin tumour due to a clonal proliferation of keratinocytes and is characterised by a telltale annular threadlike configuration along the border of a skin-colored to erythematous papule that can expand centrifugally. CASE PRESENTATION: We are presenting a clinical and dermoscopic case of pigmented disseminated superficial actinic porokeratosis (DSAP) limited to the upper trunk of a white man with sun-damaged skin...
September 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28906091/acquired-disseminated-superficial-porokeratosis-in-a-patient-affected-by-chronic-lymphocitic-leukemia
#10
Luigi Rossiello, Amalia Lupoli, Francescamaria Ruggiero, Amedeo Boscaino, Roberto Cozzi
No abstract text is available yet for this article.
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28894928/enhanced-dendritic-cells-and-regulatory-t-cells-in-the-dermis-of-porokeratosis
#11
Kanako Matsuyama, Yoko Mizutani, Tomoko Takahashi, En Shu, Hiroyuki Kanoh, Tatsuhiko Miyazaki, Mariko Seishima
Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS)...
September 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28817832/successful-use-of-grenz-rays-for-disseminated-superficial-actinic-porokeratosis-report-of-8-cases
#12
Egle Ramelyte, Matilda Bylaite-Bucinskiene, Reinhard Dummer, Laurence Imhof
BACKGROUND: Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder with potential malignant transformation, for which present treatment strategies show limited success. AIM: To evaluate the response of DSAP lesions to grenz ray radiotherapy (RTx). METHODS: Data of patients treated with RTx at University Hospital Zurich, Switzerland, between 2004 and 2015, were reviewed. Patients with DSAP, who received at least 1 RTx treatment session and who had been followed up for at least 4 weeks were included in the further data analysis...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28777842/-analysis-of-clinical-and-genetic-features-of-nine-patients-with-disseminated-superfacial-actinic-porokeratosis
#13
Xiuling Li, Qian Zhou, Lude Zhu, Zijun Zhao, Peiru Wang, Linglin Zhang, Guolong Zhang, Xiuli Wang
OBJECTIVE: To analyze the clinical and genetic features of 9 ethnic Han Chinese patients with disseminated superfacial actinic porokeratosis (DSAP). METHODS: Genomic DNA was extracted from peripheral blood samples collected from the patients. PCR and direct sequencing were carried out for five patients from a family, 4 sporadic cases, and 120 healthy controls to identify potential mutations of four genes (MVK, MVD, PMVK, FDPS) involved in the mevalonate pathway as well as SLC17A9, SSH1, and SART3 genes...
August 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28765912/disorder-of-the-mevalonate-pathway-inhibits-calcium-induced-differentiation-of-keratinocytes
#14
Rui Jin, Xin Luo, Kang Luan, Li Liu, Liang-Dan Sun, Sen Yang, Sheng-Quan Zhang, Xue-Jun Zhang
Mutation of genes encoding the enzymes of the mevalonate pathway cause a variety of diseases, including skin disorders. Mutation of four genes in this pathway, including mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase and farnesyl diphosphate synthase, have demonstrated to be responsible for porokeratosis (PK). However, the pathogenesis of PK remains unclear. In the present study, specific enzyme inhibitors of the mevalonate pathway, including pravastatin (PRA), alendronate (ALD), farnesyl transferase inhibitor (FTI‑277) and geranylgeranyl transferase inhibitor (GGTI‑298), were used to investigate the effect on differentiation of keratinocytes (KCs)...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28761862/dermoscopy-of-porokeratosis-of-mibelli
#15
Abhijeet K Jha, Sidharth Sonthalia, Aimilios Lallas
No abstract text is available yet for this article.
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28761308/porokeratosis-ptychotropica-coexisting-with-tinea-corporis
#16
Solam Lee, Sung Jay Choe, Sung Ku Ahn
No abstract text is available yet for this article.
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28748571/follicular-porokeratosis-four-new-cases
#17
A Sud, A R Shipman, M Odeke, K Varma, M Read-Jones, R A Carr
Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer)...
July 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28685731/dermoscopic-features-and-gene-mutation-in-the-mevalonate-pathway-of-five-sporadic-patients-with-porokeratosis
#18
Rui-Feng Sun, Hui Chen, Wei Zhu, Shi Lian
No abstract text is available yet for this article.
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28677581/follicular-porokeratosis-a-case-study-and-literature-review
#19
Ruifeng Sun, Hui Chen, Shi Lian, Wei Zhu
No abstract text is available yet for this article.
June 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28664560/porokeratosis-ptychotropica-a-giant-lesion-in-a-chinese-man
#20
Qian Wang, Huiying Wan, Wei Liu, Lixia Zhang
No abstract text is available yet for this article.
June 30, 2017: Australasian Journal of Dermatology
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