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Porokeratosis

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https://www.readbyqxmd.com/read/28906091/acquired-disseminated-superficial-porokeratosis-in-a-patient-affected-by-chronic-lymphocitic-leukemia
#1
Luigi Rossiello, Amalia Lupoli, Francescamaria Ruggiero, Amedeo Boscaino, Roberto Cozzi
No abstract text is available yet for this article.
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28894928/enhanced-dendritic-cells-and-regulatory-t-cells-in-the-dermis-of-porokeratosis
#2
Kanako Matsuyama, Yoko Mizutani, Tomoko Takahashi, En Shu, Hiroyuki Kanoh, Tatsuhiko Miyazaki, Mariko Seishima
Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS)...
September 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28817832/successful-use-of-grenz-rays-for-disseminated-superficial-actinic-porokeratosis-report-of-8-cases
#3
Egle Ramelyte, Matilda Bylaite-Bucinskiene, Reinhard Dummer, Laurence Imhof
BACKGROUND: Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder with potential malignant transformation, for which present treatment strategies show limited success. AIM: To evaluate the response of DSAP lesions to grenz ray radiotherapy (RTx). METHODS: Data of patients treated with RTx at University Hospital Zurich, Switzerland, between 2004 and 2015, were reviewed. Patients with DSAP, who received at least 1 RTx treatment session and who had been followed up for at least 4 weeks were included in the further data analysis...
August 18, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28777842/-analysis-of-clinical-and-genetic-features-of-nine-patients-with-disseminated-superfacial-actinic-porokeratosis
#4
Xiuling Li, Qian Zhou, Lude Zhu, Zijun Zhao, Peiru Wang, Linglin Zhang, Guolong Zhang, Xiuli Wang
OBJECTIVE: To analyze the clinical and genetic features of 9 ethnic Han Chinese patients with disseminated superfacial actinic porokeratosis (DSAP). METHODS: Genomic DNA was extracted from peripheral blood samples collected from the patients. PCR and direct sequencing were carried out for five patients from a family, 4 sporadic cases, and 120 healthy controls to identify potential mutations of four genes (MVK, MVD, PMVK, FDPS) involved in the mevalonate pathway as well as SLC17A9, SSH1, and SART3 genes...
August 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28765912/disorder-of-the-mevalonate-pathway-inhibits-calcium-induced-differentiation-of-keratinocytes
#5
Rui Jin, Xin Luo, Kang Luan, Li Liu, Liang-Dan Sun, Sen Yang, Sheng-Quan Zhang, Xue-Jun Zhang
Mutation of genes encoding the enzymes of the mevalonate pathway cause a variety of diseases, including skin disorders. Mutation of four genes in this pathway, including mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase and farnesyl diphosphate synthase, have demonstrated to be responsible for porokeratosis (PK). However, the pathogenesis of PK remains unclear. In the present study, specific enzyme inhibitors of the mevalonate pathway, including pravastatin (PRA), alendronate (ALD), farnesyl transferase inhibitor (FTI‑277) and geranylgeranyl transferase inhibitor (GGTI‑298), were used to investigate the effect on differentiation of keratinocytes (KCs)...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28761862/dermoscopy-of-porokeratosis-of-mibelli
#6
Abhijeet K Jha, Sidharth Sonthalia, Aimilios Lallas
No abstract text is available yet for this article.
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28761308/porokeratosis-ptychotropica-coexisting-with-tinea-corporis
#7
Solam Lee, Sung Jay Choe, Sung Ku Ahn
No abstract text is available yet for this article.
August 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28748571/follicular-porokeratosis-four-new-cases
#8
A Sud, A R Shipman, M Odeke, K Varma, M Read-Jones, R A Carr
Porokeratosis, a disorder of keratinisation, is clinically characterized by the presence of annular plaques with a surrounding keratotic ridge. Clinical variants include linear, disseminated superficial actinic, verrucous/hypertrophic, disseminated eruptive, palmoplantar and porokeratosis of Mibelli (one or two typical plaques with atrophic centre and guttered keratotic rim). All of these subtypes share the histological feature of a cornoid lamella, characterized by a column of 'stacked' parakeratosis with focal absence of the granular layer, and dysmaturation (prematurely keratinised cells in the upper spinous layer)...
July 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28685731/dermoscopic-features-and-gene-mutation-in-the-mevalonate-pathway-of-five-sporadic-patients-with-porokeratosis
#9
Rui-Feng Sun, Hui Chen, Wei Zhu, Shi Lian
No abstract text is available yet for this article.
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28677581/follicular-porokeratosis-a-case-study-and-literature-review
#10
Ruifeng Sun, Hui Chen, Shi Lian, Wei Zhu
No abstract text is available yet for this article.
June 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28664560/porokeratosis-ptychotropica-a-giant-lesion-in-a-chinese-man
#11
Qian Wang, Huiying Wan, Wei Liu, Lixia Zhang
No abstract text is available yet for this article.
June 30, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28632889/onychodystrophy-due-to-porokeratosis-of-mibelli-a-rare-association
#12
Manoj Pawar
Porokeratosis is a specific keratinization disorder that manifests clinically as well-demarcated annular or linear keratotic plaques of various sizes and forms and with distinguished histology showing cornoid lamella, which is a column of closely packed parakeratotic cells extending through the stratum corneum. Nail changes secondary to porokeratotic lesions involving digits are quite uncommon and rarely reported in the porokeratosis of Mibelli (PM) subtype. Here we report the case of a young girl with a PM lesion over the hand along with nail dystrophy of the involved digit...
June 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28632808/unilateral-verrucous-porokeratosis-of-the-gluteal-cleft
#13
Bruno A Schmitz, Timothy C Sorrells, Wilber Delorme
No abstract text is available yet for this article.
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28580653/porokeratosis-ptychotropica-responding-to-photodynamic-therapy-an-alternative-treatment-for-a-refractory-disease
#14
Xavier Fustà-Novell, Sebastian Podlipnik, Andrea Combalia, Daniel Morgado-Carrasco, Juan Ferrando, Jose Manuel Mascaró, Paula Aguilera
BACKGROUND: Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis with a special predisposition to affect body folds, particularly the intergluteal cleft. This disease is resistant to most topical and systemic treatments, as shown in the review of the literature we provide here. Itching and discomfort are often a difficult problem to solve. PATIENTS AND METHODS: Two patients with PP that had not responded to multiple topical treatments were treated with photodynamic therapy (PDT)...
June 5, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28566925/p16-ink4a-expression-in-porokeratosis
#15
Miki Uryu, Masutaka Furue
No abstract text is available yet for this article.
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28543730/treatment-of-disseminated-superficial-actinic-porokeratosis-with-oral-alitretinoin
#16
LETTER
B J Park, E H Oh, J E Kim, J Y Ko, Y S Ro
No abstract text is available yet for this article.
May 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28543715/a-novel-nonframeshift-deletion-in-mvk-gene-responsible-for-disseminated-superficial-actinic-porokeratosis-in-one-chinese-family
#17
Chang-Xing Li, Si-Long Sun, Jing-Yao Liang, Yao-Qin Yuan, San-Quan Zhang, Ping-Jiao Chen, Kang Zeng, Xue-Feng Xie, Xi-Bao Zhang
Disseminated superficial actinic porokeratosis (DSAP), a genodermatosis transmitted as an autosomal dominant trait featuring disorder of keratinization, is characterized clinically by annular plaques with an atropic center and hyperkeratotic edges.(1-4) Recently, Zhang et al. (2) reported MVK mutations in 33% familiar and 16% sporadic patients with DSAP by exome sequencing. Here, we report a single novel mutation of MVK, p.Cys161_Arg176del, in a Chinese family suffering from DSAP. This article is protected by copyright...
May 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28543397/a-case-of-porokeratosis-ptychotropica-successful-treatment-with-topical-5-imiquimod-cream
#18
Y Kawakami, S Mitsui
No abstract text is available yet for this article.
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28398427/disseminated-superficial-actinic-porokeratosis-treated-with-ingenol-mebutate-gel-0-05
#19
Isabella Anderson, Ethan T Routt, Shelbi C Jim On
Disseminated superficial actinic porokeratosis (DSAP) is a chronic condition characterized by numerous atrophic papules and patches with a distinctive peripheral keratotic ridge, typically found on sun-exposed areas. Treatment of DSAP is warranted not only for cosmetic and symptomatic benefits but also to prevent malignant transformation. Successful treatment of DSAP often is difficult and frequently requires the use of multiple modalities. Ingenol mebutate gel 0.05% is a topical medication primarily used for the treatment of actinic keratosis (AK) by inducing cell death...
March 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28300921/porokeratosis-ptychotropica
#20
Ana Carolina Franco Tebet, Tatiana Gandolfi de Oliveira, Anna Rita Ferrante Mitidieri de Oliveira, Fabiolla Sih Moriya, Jayme de Oliveira, Luiz Carlos Cucé
Porokeratosis is a skin disorder clinically characterized by annular plaques with keratotic borders resembling the Great Wall of China and histopathologically by cornoid lamellae. The disease has several clinical variants. Porokeratosis ptychotropica, which has recently become part of these variants, is quite rare and little known. The entity is characterized by verrucous plaques - which may resemble a psoriasis plaque - that affect the regions of the buttocks, most commonly the gluteal cleft, with or without extremity involvement...
September 2016: Anais Brasileiros de Dermatologia
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