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Porokeratosis

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https://www.readbyqxmd.com/read/29750048/genitogluteal-porokeratosis-a-clinical-review
#1
REVIEW
Rajiv Joshi, Khushboo Minni
Porokeratosis is an uncommon disorder of keratinization that presents with keratotic papules or annular plaques that expand centrifugally with a thread-like elevated border. A distinctive histologic structure, the cornoid lamella, is diagnostic of this disorder and consists of a column of parakeratosis with the absence of the granular layer and dyskeratotic cells in the upper spinous zone. Porokeratosis confined to the genitogluteal region is rare and may be subclassified into three types, namely, classical porokeratosis on the genital region, ptychotropic porokeratosis most often seen in the natal cleft and buttocks and penoscrotal porokeratosis that is seen on the penis and adjacent scrotal skin in young men in their third decade of life...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29722423/mutations-in-mevalonate-pathway-genes-in-patients-with-familial-or-sporadic-porokeratosis
#2
Yunji Leng, Lulu Yan, Hongquan Feng, Chen Chen, Shusen Wang, Yang Luo, Lihua Cao
Porokeratosis comprises heterogeneous keratinization disorders that are characterized by one or more atrophic patches surrounded by a ridge-like cornoid lamella. In this study, we evaluated seven families affected by porokeratosis and five sporadic patients of the disease in a Chinese population. We performed Sanger sequencing of exons and flanking intron-exon boundaries of mevalonate pathway genes (MVD, MVK, PMVK and FDPS) and of SLC17A9. In five familial and three sporadic patients, we detected six variations, including four novel mutations (MVD c...
May 3, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29719023/maximizing-the-clinical-utility-of-descriptive-lymphoid-pathology-reporting
#3
Timothy H McCalmont
Dermatopathology reporting can be both exact and inexact. Exact reporting represents the use of terminology that corresponds to a disease sui generis, such as discoid lupus erythematosus or disseminated superficial porokeratosis. Inexact reporting can vary greatly amongst various practitioners-both in terms of the exact semantics used and also stylistically-and can be used habitually by pathologists as a means to provide cover for diagnostic uncertainty or inexperience. This article explores the use of descriptive (inexact) reporting as it applies to cutaneous lymphoma and its differential diagnosis...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29706025/disseminated-filiform-hyperkeratosis-a-variant-of-porokeratosis
#4
A Kaushik, S Handa, D Chatterjee, V Keshavmurthy, R Mahajan
Filiform hyperkeratosis (FH) is a rare dermatosis with unresolved nosologic status, characterised by keratotic spicules in a predominant palmoplantar distribution1 . We report a case of disseminated filiform hyperkeratosis revealing a typical porokeratotic histology, and a successful therapeutic response to low dose oral isotretinoin. This article is protected by copyright. All rights reserved.
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29693064/novel-mevalonate-kinase-missense-mutation-in-a-patient-with-disseminated-superficial-actinic-porokeratosis
#5
George D Glinos, Irena Pastar, Alessio Giubellino, Marjana Tomic-Canic, Mariya Miteva, Rivka C Stone
No abstract text is available yet for this article.
May 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29630163/a-report-and-follow-up-of-a-patient-with-disseminated-superficial-actinic-porokeratosis-dsap-undergoing-novel-systemic-treatment-with-palifermin-a-keratinocyte-growth-factor-during-chemotherapy
#6
Matthew Howard, Anthony Hall
Disseminated superficial actinic porokeratosis (DSAP) is an inherited dermatosis triggered by chronic ultraviolet light exposure. Cosmetic improvement has been noted with topical therapies or laser treatment. Lesions of DSAP are precancerous, having been reported to develop into squamous cell carcinomas (SCCs) or basal cell carcinomas (BCCs) occasionally. We describe a patient with longstanding DSAP who developed a primary CNS lymphoma. Palifermin (a keratinocyte growth factor analogue) was used as an adjuvant for his chemotherapy to minimize mucositis...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29606833/disseminated-superficial-actinic-porokeratosis-in-a-vitiligo-patient-undergoing-treatment-with-long-term-narrowband-ultraviolet-b
#7
Eun-Jae Shin, Min Jae Gwak, Ki-Heon Jeong, Mu-Hyoung Lee
No abstract text is available yet for this article.
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29606819/disseminated-superficial-actinic-porokeratosis-in-a-patient-with-psoriasis-after-long-term-narrowband-ultraviolet-b-phototherapy
#8
Chang Yoon Sim, Ji Yeoun Shin, Sung Yul Lee, Young Lip Park
Porokeratosis is a rare epidermal disorder characterized by annular or linear hyperkeratotic plaques with slightly raised thread-like borders, and in most cases, atrophic centers. Disseminated superficial porokeratosis and disseminated superficial actinic porokeratosis (DSAP), which primarily involve sun-exposed areas, are common types of porokeratoses. Histologically, a column of parakeratotic cells, a so-called cornoid lamella, is a hallmark of porokeratosis. Porokeratosis is considered to result from the inability to eliminate an abnormal keratinocyte clone induced by genetic factors and various stimuli, including sunlight, artificial ultraviolet light, viral infections, immunosuppressive conditions (hematologic malignancies, organ transplants, or autoimmune disease), and immunosuppressive therapies...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29484012/disseminated-porokeratosis-with-idiopathic-thrombocytopenia-case-report-and-literature-review-of-porokeratosis-and-related-disorders
#9
Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Georgi Konstantinov Maximov, Ilia Lozev, Georgi Tchernev
BACKGROUND: Porokeratosis is characterised by one or more atrophic patches surrounded by a distinctive peripheral keratotic ridge, typically found on sun-exposed areas, with several clinical variants and typical histological findings. Despite ultraviolet radiation, varies antibody - related autoimmune disease treated with systemic steroids and other immunosuppressive conditions such as chronic liver disease, HIV and organ transplantations have been implicated in its etiopathology. CASE REPORT: We present a case of porokeratosis, associated with idiopathic thrombocytopenia in 74 - year old, otherwise healthy male patient, as we discuss the previously reported associated disorders...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29341221/pediatric-penile-porokeratosis-a-case-report
#10
Omar Bari, Antoanella Calame, Sarah Marietti-Shepherd, Victoria R Barrio
We present what we believe to be the second case of pediatric penile porokeratosis and the youngest case reported. A 6-year-old boy presented with a pruritic, verrucous growth at the urethral meatus that recurred after two meatotomies. The diagnosis of porokeratosis was confirmed by biopsy. Porokeratosis should be added to the differential diagnosis of chronic hyperkeratotic penile lesions in children.
January 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29232434/linear-porokeratosis-associated-with-multiple-squamous-cell-carcinomas
#11
Blake Friedman, Kseniya Golubets, Jonhan Ho, Timothy Patton
Linear porokeratosis is a rare subtype of porokeratosis with a higher rate of malignant transformation than other subtypes of porokeratosis. Identification of cornoid lamellae on histology allows for definitive diagnosis, which makes high clinical suspicion and appropriate biopsy essential in establishing the correct diagnosis and developing an effective management plan. We present a case report of linear porokeratosis and discuss aspects of etiology, diagnosis, and management.
November 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29221722/ink-enhanced-dermoscopy-is-a-useful-tool-to-differentiate-acquired-solitary-plaque-porokeratosis-from-other-scaly-lesions
#12
Cristián Navarrete-Dechent, Pablo Uribe, Ashfaq Marghoob
No abstract text is available yet for this article.
December 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29221608/a-case-of-eruptive-disseminated-porokeratosis-in-a-cancer-patient-after-trastuzumab-and-exemestane-treatment-cancer-related-or-drug-induced-phenomenon
#13
C Mangas, V Espeli, R Blum
No abstract text is available yet for this article.
December 5, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29194784/inflammatory-disseminated-superficial-porokeratosis-successfully-controlled-with-a-combination-of-topical-diclofenac-gel-and-systemic-etretinate
#14
LETTER
S Shimizu, Y Takashima, M Hotta, E Ito, R Moriuchi
No abstract text is available yet for this article.
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29159004/linear-malignant-melanoma-in-situ-reports-and-review-of-cutaneous-malignancies-presenting-as-linear-skin-cancer
#15
Philip R Cohen
Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. A medical literature search engine, PubMed, was used to search the following terms: cancer, cutaneous, in situ, linear, malignant, malignant melanoma, melanoma in situ, neoplasm, and skin...
September 18, 2017: Curēus
https://www.readbyqxmd.com/read/28976625/amelanotic-melanoma-arising-within-a-lesion-of-disseminated-superficial-actinic-porokeratosis-an-unusual-presentation-leading-to-a-novel-therapeutic-approach
#16
Ali Al-Haseni, Pooja Chitgopeker, Jonathan D Ho, Lynne J Goldberg, Debjani Sahni
Disseminated superficial actinic porokeratosis (DSAP) is the most common variant of porokeratosis with a potential for malignant transformation. Its association with malignant melanoma, however, is exceedingly rare. Treatment of DSAP is often ineffective. We report a unique case of amelanotic melanoma arising within a lesion of DSAP. The melanoma was managed surgically, and her DSAP were treated successfully with a novel approach utilizing 5-fluorouracil chemowraps.
January 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/28940636/porokeratosis-ptychotropica-a-diagnostic-and-therapeutic-challenge
#17
LETTER
J Contreras-Ruiz, S Toussaint-Caire, P Torres-Camacho, V B Villa-Castro
No abstract text is available yet for this article.
March 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28922948/clinical-and-dermoscopic-features-of-pigmented-disseminated-superficial-actinic-porokeratosis-case-report-and-literature-review
#18
Bahman Sotoodian, Muhammad N Mahmood, Thomas G Salopek
INTRODUCTION: Porokeratosis is a benign hyperkeratotic skin tumour due to a clonal proliferation of keratinocytes and is characterised by a telltale annular threadlike configuration along the border of a skin-colored to erythematous papule that can expand centrifugally. CASE PRESENTATION: We are presenting a clinical and dermoscopic case of pigmented disseminated superficial actinic porokeratosis (DSAP) limited to the upper trunk of a white man with sun-damaged skin...
September 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28906091/acquired-disseminated-superficial-porokeratosis-in-a-patient-affected-by-chronic-lymphocitic-leukemia
#19
LETTER
Luigi Rossiello, Amalia Lupoli, Francescamaria Ruggiero, Amedeo Boscaino, Roberto Cozzi
No abstract text is available yet for this article.
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28894928/enhanced-dendritic-cells-and-regulatory-t-cells-in-the-dermis-of-porokeratosis
#20
Kanako Matsuyama, Yoko Mizutani, Tomoko Takahashi, En Shu, Hiroyuki Kanoh, Tatsuhiko Miyazaki, Mariko Seishima
Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS)...
September 11, 2017: Archives of Dermatological Research
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