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bizarre delusions means in schizophrenia

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https://www.readbyqxmd.com/read/27136403/clinical-characteristics-and-predictors-of-outcome-of-schizophrenia-spectrum-psychosis-in-children-and-adolescents-a-systematic-review
#1
Marie Stentebjerg-Olesen, Anne K Pagsberg, Anders Fink-Jensen, Christoph U Correll, Pia Jeppesen
OBJECTIVE: Treatment of early-onset schizophrenia spectrum psychosis (EOS) is hampered by limited data on clinical presentation and illness course. We aimed to systematically review the clinical characteristics, diagnostic trajectories, and predictors of illness severity and outcomes of EOS. METHODS: We conducted a systematic PubMed, PsycINFO, and Embase literature review including studies published from January 1, 1990 to August 8, 2014 of EOS patients with 1) ≥50% nonaffective psychosis cases; 2) mean age of subjects <19 years; 3) clinical samples recruited through mental health services; 4) cross-sectional or prospective design; 5) ≥20 participants at baseline; 6) standardized/validated diagnostic instruments; and 7) quantitative psychotic symptom frequency or severity data...
June 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26151103/decomposition-of-brain-diffusion-imaging-data-uncovers-latent-schizophrenias-with-distinct-patterns-of-white-matter-anisotropy
#2
Javier Arnedo, Daniel Mamah, David A Baranger, Michael P Harms, Deanna M Barch, Dragan M Svrakic, Gabriel A de Erausquin, C Robert Cloninger, Igor Zwir
Fractional anisotropy (FA) analysis of diffusion tensor-images (DTI) has yielded inconsistent abnormalities in schizophrenia (SZ). Inconsistencies may arise from averaging heterogeneous groups of patients. Here we investigate whether SZ is a heterogeneous group of disorders distinguished by distinct patterns of FA reductions. We developed a Generalized Factorization Method (GFM) to identify biclusters (i.e., subsets of subjects associated with a subset of particular characteristics, such as low FA in specific regions)...
October 15, 2015: NeuroImage
https://www.readbyqxmd.com/read/25943123/psychopathology-of-lived-time-abnormal-time-experience-in-persons-with-schizophrenia
#3
Giovanni Stanghellini, Massimo Ballerini, Simona Presenza, Milena Mancini, Andrea Raballo, Stefano Blasi, John Cutting
Abnormal time experience (ATE) in schizophrenia is a long-standing theme of phenomenological psychopathology. This is because temporality constitutes the bedrock of any experience and its integrity is fundamental for the sense of coherence and continuity of selfhood and personal identity. To characterize ATE in schizophrenia patients as compared to major depressives we interviewed, in a clinical setting over a period of 15 years, 550 consecutive patients affected by schizophrenic and affective disorders. Clinical files were analyzed by means of Consensual Qualitative Research (CQR), an inductive method suited to research that requires rich descriptions of inner experiences...
January 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/22239570/abnormal-bodily-experiences-may-be-a-marker-of-early-schizophrenia
#4
COMPARATIVE STUDY
Giovanni Stanghellini, Massimo Ballerini, Paolo Fusar Poli, John Cutting
The purpose of this study is to answer the following question: What are the typical features of abnormal bodily experiences (ABEs) in persons affected by acute first-episode schizophrenia? Our overall objective is to contribute to enhance early diagnosis of schizophrenia, and providing supplementary diagnostic criteria especially for ultra-high risk patients. In a group of 39 patients with first-episode schizophrenia selected from a sample of 393 psychotic patients, 30 (76.9 %) reported ABEs. By means of a phenomenologically-based qualitative method of inquiry, we recognized four subtypes of ABEs whose main characteristics are dynamization of bodily boundaries and construction, morbid objectivization/devitalization, dysmorphic experiences and pain-like experiences...
2012: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/22034458/the-french-concept-of-psychose-hallucinatoire-chronique-a-preliminary-form-of-schizophrenia-the-role-of-late-life-psychosis-in-the-anticipation-hypothesis-of-schizophrenia
#5
C Dubertret, P Gorwood
The distinction between schizophrenia and chronic delusional syndromes (including the French concept of "psychose hallucinatoire chronique" [PHC] or chronic psychotic hallucinations, paraphrenia, and late paraphrenia) is currently used in various European countries, although there are no international criteria for chronic and bizarre delusions. The French concept of PHC is characterized by late-onset psychosis, predominantly in females, with rich and frequent hallucinations, but almost no dissociative features or negative symptoms...
December 2001: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/19251247/dopamine-d2-receptor-levels-in-striatum-thalamus-substantia-nigra-limbic-regions-and-cortex-in-schizophrenic-subjects
#6
Robert M Kessler, Neil D Woodward, Patrizia Riccardi, Rui Li, M Sib Ansari, Sharlett Anderson, Benoit Dawant, David Zald, Herbert Y Meltzer
BACKGROUND: Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments. METHODS: [(18)F]fallypride positron emission tomography studies were performed in off-medication or never-medicated schizophrenic subjects (n = 11, 6 men, 5 women; mean age of 30.5 +/- 8.0 [SD] years; 4 drug-naive) and age-matched healthy subjects (n = 11, 5 men, 6 women, mean age of 31...
June 15, 2009: Biological Psychiatry
https://www.readbyqxmd.com/read/16940339/values-in-persons-with-schizophrenia
#7
Giovanni Stanghellini, Massimo Ballerini
This is an explorative study on the values of persons with schizophrenia based on transcripts of individual therapy sessions conducted for 40 persons with chart diagnoses of schizophrenia or schizotypal disorder. Values are action-guiding attitudes that subject human activities to be worthy of praise or blame. The schizophrenic value system conveys an overall crisis of common sense. The outcome of this has been designated as antagonomia and idionomia. Antagonomia reflects the choice to take an eccentric stand in the face of commonly shared assumptions and the here and now "other...
January 2007: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/15993564/positive-and-negative-symptoms-in-affected-sib-pairs-with-schizophrenia-implications-for-genetic-studies-in-an-african-xhosa-sample
#8
COMPARATIVE STUDY
Dana J H Niehaus, Liezl Koen, Claudine Laurent, Jacqueline Muller, Jean-Francois Deleuze, Jacques Mallet, Cathlene Seller, Esme Jordaan, Robin Emsley
Careful phenotyping and the identification of subtypes of schizophrenia can contribute significantly to the success of genetic studies in schizophrenia. The phenomenology of schizophrenia in affected sib pairs has been well-described in Caucasian populations, however a paucity of data exists for African populations. This study therefore investigated symptom dimensions in a sizeable group of affected Xhosa sib pairs as a means of evaluating the role of shared familial factors in the psychosis of schizophrenia...
November 15, 2005: Schizophrenia Research
https://www.readbyqxmd.com/read/12127598/the-possible-pathophysiological-role-of-plasma-nitric-oxide-and-adrenomedullin-in-schizophrenia
#9
S Salih Zoroglu, Hasan Herken, Muhittin Yürekli, Efkan Uz, Hamdi Tutkun, Haluk A Savaş, Cahit Bagci, Murat Eren Ozen, Beyhan Cengiz, Ecir Ali Cakmak, M Ilker Dogru, Omer Akyol
Evidence is accumulating for a possible role of nitric oxide (NO) in schizophrenia. Adrenomedullin (AM) induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of NO. AM immune reactivity is present in the brain consistent with a role as neurotransmitter. We aimed to examine plasma levels of nitrite (a metabolite of NO) and AM in schizophrenic patients. Eighty-two patients with schizophrenia and 21 healthy control subjects were included in this study. DSM-IV diagnosis of chronic schizophrenia was established on the basis of independent structured clinical interviews and review of records by two qualified psychiatrists which included the Brief Psychiatric Rating Scale (BPRS), The Scale for the Assessment of Negative Symptoms (SANS) and The Scale for the Assessment of Positive Symptoms (SAPS)...
September 2002: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/12040703/the-language-of-schizophrenia-and-the-world-of-delusion
#10
Michael Robbins
The bizarre language of schizophrenics is nowadays generally believed to be the meaningless breakdown product of a neurobiological disorder. The psychological significance of hallucinations and delusions also remains mysterious. Verbatim vignettes are presented from an advanced stage of a psychoanalytically informed treatment to illustrate that schizophrenics speak a meaningful language that is syntactically and morphologically similar to ordinary language, but is qualitatively different in terms of semantics and pragmatics...
April 2002: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/12028698/the-language-of-schizophrenia-and-the-world-of-delusion
#11
Michael Robbins
The bizarre language of schizophrenics is nowadays generally believed to be the meaningless breakdown product of a neurobiological disorder. The psychological significance of hallucinations and delusions also remains mysterious. Verbatim vignettes are presented from an advanced stage of a psychoanalytically informed treatment to illustrate that schizophrenics speak a meaningful language that is syntactically and morphologically similar to ordinary language, but is qualitatively different in terms of semantics and pragmatics...
April 2002: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/10427607/dimensional-structure-of-psychotic-symptoms-an-item-level-analysis-of-saps-and-sans-symptoms-in-psychotic-disorders
#12
COMPARATIVE STUDY
V Peralta, M J Cuesta
The factor structure of psychotic symptoms as assessed by means of the Scales for the Assessment of Positive and Negative Symptoms (SAPS and SANS) was examined in a sample of 660 psychotic inpatients. Analyses were conducted at item-level. Principal-component analysis (PCA) was used to extract factors, the OBLIMIN procedure to rotate factors, and the eigen value greater-than-one criterion to determine the number of factors. PCA resulted in 11 interpretable factors explaining 64% of the total variance: poverty of affect/speech, thought disorder/inappropriate affect, bizarre delusions, social dysfunction, other delusions, paranoid delusions, bizarre behavior, nonauditory hallucinations, auditory hallucinations, manic thought disorder, and attention...
July 27, 1999: Schizophrenia Research
https://www.readbyqxmd.com/read/7375853/platelet-monoamine-oxidase-activity-in-subgroups-of-schizophrenic-disorders
#13
J J Schildkraut, P J Orsulak, A F Schatzberg, J M Herzog
This article summarizes findings from a series of studies that examined platelet monoamine oxidase (MAO) activity in patients with nonaffective schizophrenic disorders and schizophrenia-related depressions. The findings indicate that mean platelet MAO activity was not different from control values in the subgroup of nonaffective schizophrenic disorders without auditory hallucinations (that is, the S-1 subgroup). However, mean platelet MAO activity was reduced in the subgroup of nonaffective schizophrenic disorders characterized by the presence of auditory hallucinations often occurring in conjunction with paranoid features (that is, the S-2 subgroup)...
1980: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/7058942/ventricular-enlargement-in-schizophrenia-relationship-to-positive-and-negative-symptoms
#14
N C Andreasen, S A Olsen, J W Dennert, M R Smith
The authors explored the clinical correlates of ventricular enlargement in schizophrenia by comparing 16 patients with "large" ventricles (ventricles more than I SD above the control mean) with 16 patients with the smallest ventricles from a sample of 52 schizophrenic patients. Patients with ventricular enlargement showed some impairment in the sensorium and had a preponderance of "negative" symptoms (e.g., alogia, affective flattening, avolition, anhedonia), while those with small ventricles were characterized by "positive" symptoms (e...
March 1982: American Journal of Psychiatry
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