keyword
https://read.qxmd.com/read/38520402/pacemaking-in-the-lymphatic-system
#1
JOURNAL ARTICLE
Michael J Davis, Scott D Zawieja
Lymphatic collecting vessels exhibit spontaneous phasic contractions that are critical for lymph propulsion and tissue fluid homeostasis. This rhythmic activity is driven by action potentials conducted across the lymphatic muscle cell (LMC) layer to produce entrained contractions. The contraction frequency of a lymphatic collecting vessel displays exquisite mechanosensitivity, with a dynamic range from <1 to >20 contractions per minute. A myogenic pacemaker mechanism intrinsic to the LMCs was initially postulated to account for pressure-dependent chronotropy...
March 23, 2024: Journal of Physiology
https://read.qxmd.com/read/38514195/dural-metastasis-in-breast-cancer-mri-based-morphological-subtypes-and-their-clinical-implications
#2
JOURNAL ARTICLE
Sung Jun Ahn, Bio Joo, Mina Park, Hun Ho Park, Sang Hyun Suh, Sung Gwe Ahn, Jihwan Yoo
PURPOSE: To investigate the clinical factors associated with breast cancer (BRCA) dural metastases (DMs), their impact on prognosis compared to brain parenchymal metastases (BPMs) alone, and differences between DM subtypes, aiming to inform clinical decisions. MATERIALS AND METHODS: We retrospectively analyzed 119 patients with BRCA with brain metastasis, including 91 patients with BPM alone and 28 patients with DM. Univariate and multivariate analyses were performed to compare the clinical characteristics between the two groups and within subtypes of DM...
March 19, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/38476802/palliative-treatment-of-leptomeningeal-carcinomatosis-from-renal-cell-carcinoma-with-local-cyberknife-radiotherapy-and-systemic-pazopanib-therapy-a-case-report
#3
Shinichiro Mizumatsu, Kenichi Wakabayashi, Yasuhiro Terashima
Leptomeningeal carcinomatosis (LMC) from renal cell carcinoma (RCC) is rare. There is no established treatment strategy for LMC, and the prognosis is extremely poor. We describe a case of LMC from RCC treated with local CyberKnife radiotherapy (CKR) and systemic therapy with pazopanib. The patient was a 63-year-old man with brain metastases from right RCC. Surgery and CKR were performed for the brain metastases, and the lesions were subsequently controlled. The patient developed isolated lesions in the pituitary stalk, right internal auditory canal, left ventricular choroid plexus (CP), left facial nerve, and medulla oblongata after the surgery and CKR for brain metastases...
February 2024: Curēus
https://read.qxmd.com/read/38434413/characterization-of-primary-human-leptomeningeal-cells-in-2d-culture
#4
JOURNAL ARTICLE
Mannthalah Abubaker, Aisling Greaney, David Newport, John J E Mulvihill
Maintaining the integrity of brain barriers is critical for a healthy central nervous system. While extensive research has focused on the blood-brain barrier (BBB) of the brain vasculature and blood-cerebrospinal fluid barrier (BCSFB) of the choroid plexus, the barriers formed by the meninges have not received as much attention. These membranes create a barrier between the brain and cerebrospinal fluid (CSF), as well as between CSF and blood. Recent studies have revealed that this barrier has been implicated in the development of neurological and immunological disorders...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38392336/central-autonomic-mechanisms-involved-in-the-control-of-laryngeal-activity-and-vocalization
#5
REVIEW
Marta González-García, Laura Carrillo-Franco, Carmen Morales-Luque, Marc Stefan Dawid-Milner, Manuel Víctor López-González
In humans, speech is a complex process that requires the coordinated involvement of various components of the phonatory system, which are monitored by the central nervous system. The larynx in particular plays a crucial role, as it enables the vocal folds to meet and converts the exhaled air from our lungs into audible sounds. Voice production requires precise and sustained exhalation, which generates an air pressure/flow that creates the pressure in the glottis required for voice production. Voluntary vocal production begins in the laryngeal motor cortex (LMC), a structure found in all mammals, although the specific location in the cortex varies in humans...
February 13, 2024: Biology
https://read.qxmd.com/read/38372902/leptomeningeal-carcinomatosis-and-brain-metastases-in-gastroesophageal-carcinoma-a-real-world-analysis-of-clinical-and-pathologic-characteristics-and-outcomes
#6
JOURNAL ARTICLE
Thais Baccili Cury Megid, Zeynep Baskurt, Lucy X Ma, Carly C Barron, Abdul Farooq, Marie Phillipe Saltiel, Xin Wang, Yvonne Bach, Hiroko Ayoama, Raymond W Jang, Eric Chen, Patrick Veit-Haibach, Ben Wang, Sangeetha Kalimuthu, James Cotton, Rebecca Wong, Aruz Mesci, Elena Elimova
BACKGROUND: Brain metastasis (BrM) and Leptomeningeal Carcinomatosis (LMC) are uncommon complications in gastroesophageal carcinoma (GEC) patients. These patients have a poor prognosis and are challenging to treat. We described the clinicopathologic features and outcomes in the largest cohort of Central Nervous System (CNS) metastasis in GEC patients. METHODS: single-center retrospective study of GEC treated from 2007 to 2021. Clinicopathologic characteristics and treatment modalities were reviewed...
February 19, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38335670/electrostatic-particle-ionization-for-suppressing-air-pollutants-in-cage-free-layer-facilities
#7
JOURNAL ARTICLE
Ramesh Bahadur Bist, Xiao Yang, Sachin Subedi, Casey W Ritz, Woo Kyun Kim, Lilong Chai
The increasing demand for cage-free (CF) poultry farming raises concern regarding air pollutant emissions in these housing systems. Previous studies have indicated that air pollutants such as particulate matter (PM) and ammonia (NH3 ) pose substantial risks to the health of birds and workers. This study aimed to evaluate the efficacy of electrostatic particle ionization (EPI) technology with different lengths of ion precipitators in reducing air pollutants and investigate the relationship between PM reduction and electricity consumption...
January 24, 2024: Poultry Science
https://read.qxmd.com/read/38313981/leptomeningeal-carcinomatosis-from-primary-mucinous-carcinoma-of-the-ovary
#8
Alexander Dye, Rachel Stein, Gregory Lewis, Karina Hew
Leptomeningeal carcinomatosis (LMC) is an extremely rare site for metastasis from a primary ovarian cancer. LMC occurs when the thin layers of tissue that surround the brain and spinal cord are infiltrated by ovarian cancer metastasis. We present a case of a 63-year-old female with recurrent metastatic mucinous adenocarcinoma of the ovary who was diagnosed with LMC. While undergoing sixth-line chemotherapy, she presented with debilitating headaches and gait instability. Brain MRI revealed subarachnoid enhancement and other findings diagnostic of LMC...
January 2024: Curēus
https://read.qxmd.com/read/38181494/intraoperative-cortical-stimulation-mapping-with-laryngeal-electromyography-for-the-localization-of-human-laryngeal-motor-cortex
#9
JOURNAL ARTICLE
Simon G Ammanuel, Sravani Kondapavulur, Alex Y Lu, Jonathan D Breshears, John P Clark, Alexander B Silva, Edward F Chang
OBJECTIVE: The objectives of this study were to describe the authors' clinical methodology and outcomes for mapping the laryngeal motor cortex (LMC) and define localization of the LMC in a cohort of neurosurgical patients undergoing intraoperative brain mapping. Because of mapping variability across patients, the authors aimed to define the probabilistic distribution of cortical sites that evoke laryngeal movement, as well as adjacent cortical somatotopic representations for the face (mouth), tongue, and hand...
January 5, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38173954/biochar-and-seed-priming-technique-with-gallic-acid-an-approach-toward-improving-morpho-anatomical-and-physiological-features-of-solanum-melongena-l-under-induced-nacl-and-boron-stresses
#10
JOURNAL ARTICLE
Shumaila, Sami Ullah, Wadood Shah, Aqsa Hafeez, Baber Ali, Shahid Khan, Sezai Ercisli, Abdullah Ahmed Al-Ghamdi, Mohamed S Elshikh
Dynamic shifts in climatic patterns increase soil salinity and boron levels, which are the major abiotic factors that affect plant growth and secondary metabolism. The present study assessed the role of growth regulators, including biochar (5 g kg-1 ) and gallic acid (GA, 2 mM), in altering leaf morpho-anatomical and physiological responses of Solanum melongena L. exposed to boron (25 mg kg-1 ) and salinity stresses (150 mM NaCl). These growth regulators enhanced leaf fresh weight (LFW) (70%), leaf dry weight (LDW) (20%), leaf area (LA), leaf area index (LAI) (85%), leaf moisture content (LMC) (98%), and relative water content (RWC) (115%) under salinity and boron stresses...
August 8, 2023: ACS Omega
https://read.qxmd.com/read/38147151/lysosomal-sialidase-neu1-its-intracellular-properties-deficiency-and-use-as-a-therapeutic-agent
#11
REVIEW
Kohji Itoh, Jun Tsukimoto
Neuraminidase 1 (NEU1) is a lysosomal sialidase that cleaves terminal α-linked sialic acid residues from sialylglycans. NEU1 is biosynthesized in the rough endoplasmic reticulum (RER) lumen as an N-glycosylated protein to associate with its protective protein/cathepsin A (CTSA) and then form a lysosomal multienzyme complex (LMC) also containing β-galactosidase 1 (GLB1). Unlike other mammalian sialidases, including NEU2 to NEU4, NEU1 transport to lysosomes requires association of NEU1 with CTSA, binding of the CTSA carrying terminal mannose 6-phosphate (M6P)-type N-glycan with M6P receptor (M6PR), and intralysosomal NEU1 activation at acidic pH...
December 26, 2023: Glycoconjugate Journal
https://read.qxmd.com/read/38141990/applying-thallium-isotopic-compositions-as-novel-and-sensitive-proxy-for-tl-i-tl-iii-transformation-and-source-apportionment
#12
JOURNAL ARTICLE
Juan Liu, Lulu Wang, Jingfen Lin, Wenhuan Yuan, Liangzhong Li, Yung-Kang Peng, Xinni Xiong, Huimin Cao, Xudong Wei, Qi'en Ouyang, Holger Lippold, Jin Wang, Ke Lin
Thallium is a rare metal known for its highly toxic nature. Recent research has indicated that the precise determination of Tl isotopic compositions using Multi-Collector Inductively Coupled Plasma Mass Spectrometry (MC-ICP MS) provides new opportunities for understanding Tl geochemical behavior. While isotopic fractionation of Tl derived from anthropogenic activities (e.g., mining, smelting) have been reported, there is limited information regarding Tl influenced by both natural weathering processes and anthropogenic origins...
December 21, 2023: Science of the Total Environment
https://read.qxmd.com/read/38098918/leptomeningeal-carcinomatosis-a-rare-presentation-of-perforated-gastric-cancer
#13
Klara Schwarzova, Xiaolong Li, Faith Adekunle, Alok Gupta
Leptomeningeal carcinomatosis (LMC) or leptomeningeal metastasis is defined as metastasis to the pia mater, arachnoid, and subarachnoid space. Only very few patients with cancer have LMC. In the practice of general surgeons, this diagnosis is rarely, if ever, encountered. We present a rare case of a patient presenting to ED with worsening headaches over several months that developed acute-onset abdominal pain while being evaluated. Further workup showed free air, and the patient was taken emergently to the OR, where a perforated gastric ulcer was identified and biopsied...
November 2023: Curēus
https://read.qxmd.com/read/38087729/-optimizing-the-use-of-bosutinib-in-patients-with-chronic-phase-chronic-myeloid-leukemia-recommendations-of-a-panel-of-experts-from-the-fi-lmc-french-cml-working-group
#14
REVIEW
Delphine Rea, Emilie Cayssials, Aude Charbonnier, Valérie Coiteux, Gabriel Etienne, Lauriane Goldwirt, Agnès Guerci-Bresler, Françoise Huguet, Laurence Legros, Lydia Roy, Franck Emmanuel Nicolini
The treatment of chronic myeloid leukemia relies on orally available tyrosine kinase inhibitors targeting the BCR::ABL1 oncoprotein. Bosutinib is a second generation adenosine triphosphate-competitive inhibitor approved for use in frontline adult chronic phase-chronic myeloid leukemia and all phases-chronic myeloid leukemia in the second line setting or beyond. Its efficacy was demonstrated in several pivotal clinical trials at 400mg once daily in the first line context and at 500mg once daily beyond first line...
December 11, 2023: Bulletin du Cancer
https://read.qxmd.com/read/38055694/women-veterans-perspectives-experiences-and-preferences-for-firearm-lethal-means-counseling-discussions
#15
JOURNAL ARTICLE
Evan R Polzer, Ryan Holliday, Carly M Rohs, Suzanne M Thomas, Christin N Miller, Joseph A Simonetti, Lisa A Brenner, Lindsey L Monteith
AIMS: Firearms have become an increasingly common method of suicide among women Veterans, yet this population has rarely been a focus in firearm suicide prevention research. Limited knowledge is available regarding the preferences, experiences, or needs of women Veterans with respect to firearm lethal means counseling (LMC), an evidence-based suicide prevention strategy. Understanding is necessary to optimize delivery for this population. METHOD: Our sample included forty women Veterans with lifetime suicidal ideation or suicide attempt(s) and firearm access following military separation, all enrolled in the Veterans Health Administration...
2023: PloS One
https://read.qxmd.com/read/38040145/effects-of-chitosan-molecular-weight-and-mass-ratio-with-natural-blue-phycocyanin-on-physiochemical-and-structural-stability-of-protein
#16
JOURNAL ARTICLE
Qike Li, Liang Zhang, Wenyan Liao, Jinfang Liu, Yanxiang Gao
Phycocyanin (PC), an algae-extracted colorant, has extensive applications for its water-solubility and fresh blue shade. When PC is added to acidified media, dispersions are prone to aggregate and decolorize into cloudy systems. For palliating this matter, chitosan with high, medium, and low molecular weights (HMC, MMC, and LMC) were adopted in PC dispersions, and their protective effects were compared based on physiochemical stabilities. The optimal mass ratio between chitosan and PC was identified as 1:5 based on preliminary evaluations and was supported by the higher ζ-potential (31...
November 29, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38026525/functionalized-cerium-dioxide-nanoparticles-with-antioxidative-neuroprotection-for-alzheimer-s-disease
#17
JOURNAL ARTICLE
Yu Hu, Hui Guo, Shuai Cheng, Junpeng Sun, Jiaqun Du, Xiaobang Liu, Ying Xiong, Liqing Chen, Chang Liu, Chao Wu, He Tian
BACKGROUND: Oxidative stress induced reactive oxygen species (ROS) and aggregation of amyloid β (Aβ) in the nervous system are significant contributors to Alzheimer's disease (AD). Cerium dioxide and manganese oxide are known as to be effective and recyclable ROS scavengers with high efficiency in neuroprotection. METHODS: A hollow-structured manganese-doped cerium dioxide nanoparticle (LMC) was synthesized for loading Resveratrol (LMC-RES). The LMC-RES were characterized by TEM, DLS, Zeta potential, and X-ray energy spectrum analysis...
2023: International Journal of Nanomedicine
https://read.qxmd.com/read/38024242/gliomatosis-cerebri-gc-growth-pattern-a-single-center-analysis-of-clinical-histological-and-molecular-characteristics-of-gc-and-non-gc-glioblastoma
#18
JOURNAL ARTICLE
Iris Divé, Katharina J Weber, Tabea I Hartung, Eike Steidl, Marlies Wagner, Elke Hattingen, Kea Franz, Emmanouil Fokas, Michael W Ronellenfitsch, Ulrich Herrlinger, Patrick N Harter, Joachim P Steinbach
BACKGROUND: The biological understanding of glioblastoma (GB) with gliomatosis cerebri (GC) pattern is poor due to the absence of GC-specific studies. Here, we aimed to identify molecular or clinical parameters that drive GC growth. METHODS: From our methylome database of IDH (isocitrate dehydrogenase)-wildtype GB, we identified 158 non-GC and 65 GC cases. GC cases were subdivided into diffuse-infiltrative (subtype 1), multifocal (subtype 2), or tumors with 1 solid mass (subtype 3)...
2023: Neuro-oncology advances
https://read.qxmd.com/read/38021693/a-case-of-leptomeningeal-carcinomatosis-manifesting-with-vertigo-in-the-setting-of-intracranial-hypertension
#19
Leena Saeed, Sondos K Khalil, Sulafa K Khalil, Omar A Madani, Fakhreddin Al Refai, Muzamil Musa, Ehab Adam, Husam Abu-Obieda
Leptomeningeal carcinomatosis (LMC) is a rare condition where malignant cells infiltrate the leptomeninges of the central nervous system. We present a case of a 51-year-old male with stage IV adenocarcinoma of the lung who developed recurrent vertigo. The patient initially received a diagnosis of peripheral vertigo, but his symptoms worsened over time and were associated with headache, vomiting, and one episode of seizure. Upon readmission, based on his normal neuroimaging results, normal CSF examination with elevated opening pressure, and papilledema on fundoscopic examination, a diagnosis of pseudotumor cerebri was made...
October 2023: Curēus
https://read.qxmd.com/read/38013339/small-bowel-diaphragm-disease-with-multiple-cluster-lesions-in-one-segment-of-the-small-bowel-mimicking-an-adhesion-band-a-case-report
#20
JOURNAL ARTICLE
Youseok Jeong, Jae Hun Chung, Dong Won Lim, Si Hak Lee, Sun-Hwi Hwang, Dong Hoon Shin
RATIONALE: Small bowel diaphragm disease (SBDD) is a rare case, caused by long-term administration of nonsteroidal anti-inflammatory drugs (NSAIDs). The circumferential diaphragm in the lumen of small bowel causing mechanical obstruction is the characteristic finding. PATIENT CONCERNS: A 74-year-old male was transferred to Pusan National University Yangsan Hospital (PNUYH) due to abdominal pain lasting for 2 months. He was treated in the local medical center (LMC) with Levin tube insertion and Nil Per Os (NPO) but showed no improvement...
November 24, 2023: Medicine (Baltimore)
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