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https://www.readbyqxmd.com/read/29345035/pressure-and-pipes-from-neuroimaging-to-virtual-measurement
#1
Marialuisa Zedde, Rosario Pascarella
Leng et al. [1] described the practical application of a computational fluid dynamics (CFD) model based on Computed Tomography Angiography (CTA) in 85 patients with symptomatic atherosclerotic M1 middle cerebral artery (MCA) stenosis, to virtually measure arterial pressure (AP) across the stenotic segment, according to the theory that translesional pressure gradient (PG) drives arteriologenesis and leptomeningeal collaterals (LMC) development. This is a fundamental pathophysiological issue about the risk of recurrent stroke downstream an intracranial artery stenosis and both the degree of stenosis and the collateral circulation affect it; in WASID trial [2] patients with severe (> 70%) intracranial stenosis and efficient collaterals had a lower risk of recurrent stroke than patients with poor collaterals...
January 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29343625/methicillin-resistant-staphylococcus-aureus-causes-sustained-collecting-lymphatic-vessel-dysfunction
#2
Dennis Jones, Eelco F J Meijer, Cedric Blatter, Shan Liao, Ethel R Pereira, Echoe M Bouta, Keehoon Jung, Shan Min Chin, Peigen Huang, Lance L Munn, Benjamin J Vakoc, Michael Otto, Timothy P Padera
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality worldwide and is a frequent cause of skin and soft tissue infections (SSTIs). Lymphedema-fluid accumulation in tissue caused by impaired lymphatic vessel function-is a strong risk factor for SSTIs. SSTIs also frequently recur in patients and sometimes lead to acquired lymphedema. However, the mechanism of how SSTIs can be both the consequence and the cause of lymphatic vessel dysfunction is not known. Intravital imaging in mice revealed an acute reduction in both lymphatic vessel contractility and lymph flow after localized MRSA infection...
January 17, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29276499/usability-of-videogame-based-dexterity-training-in-the-early-rehabilitation-phase-of-stroke-patients-a-pilot-study
#3
Tim Vanbellingen, Suzanne J Filius, Thomas Nyffeler, Erwin E H van Wegen
Background: Approximately 70-80% of stroke survivors have limited activities of daily living, mainly due to dexterous problems. Videogame-based training (VBT) along with virtual reality seems to be beneficial to train upper limb function. Objective: To evaluate the usability of VBT using the Leap Motion Controller (LMC) to train fine manual dexterity in the early rehabilitation phase of stroke patients as an add-on to conventional therapy. Additionally, this study aimed to estimate the feasibility and potential efficacy of the VBT...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29175019/long-term-outcome-and-quality-of-life-after-initial-and-repeat-resection-of-colorectal-liver-metastasis-a-retrospective-analysis
#4
D Heise, W Bayings, A Tuinhof, R Eickhoff, A Kroh, F Ulmer, C H C Dejong, U Neumann, M Binnebösel
BACKGROUND: Repeat hepatectomy is a widely accepted treatment for patients with recurrent colorectal liver metastasis (CRLM). The aim of this study was to compare initial and repeat hepatic resection concerning overall survival, prognostic factors and postoperative quality of life. METHODS: Data on patients who underwent initial or repeat hepatic resection for CRLM between 2010 and 2016 were prospectively collected and retrospectively evaluated. Follow-up data, EORTC QLQ-C30 and QLQ-LMC21 questionnaire results for quality of life (QoL) evaluation were analyzed...
November 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29171118/translesional-pressure-gradient-and-leptomeningeal-collateral-status-in-symptomatic-middle-cerebral-artery-stenosis
#5
Xinyi Leng, Linfang Lan, Hing Lung Ip, Florence Fan, Sze Ho Ma, Karen Ma, Haipeng Liu, Zhengzheng Yan, Jia Liu, Jill Abrigo, Yannie Oy Soo, David S Liebeskind, Ka Sing Wong, Thomas W Leung
BACKGROUND AND PURPOSE: Leptomeningeal collateral (LMC) status governs prognosis of large artery occlusive stroke, while factors determining the LMC status were not fully elucidated. We aimed to investigate metrics affecting LMC status in such patients by using computational fluid dynamics (CFD) models based on CT angiography (CTA). METHODS: In this cross-sectional study, we recruited patients with recent ischemic stroke or transient ischemic attack attributed to atherosclerotic M1 middle cerebral artery (MCA) stenosis (50-99%)...
November 24, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29169786/characterization-of-cellulolytic-microbial-consortium-enriched-on-napier-grass-using-metagenomic-approaches
#6
Pattanop Kanokratana, Sarunyou Wongwilaiwalin, Wuttichai Mhuantong, Sithichoke Tangphatsornruang, Lily Eurwilaichitr, Verawat Champreda
Energy grass is a promising substrate for production of biogas by anaerobic digestion. However, the conversion efficiency is limited by the enzymatically recalcitrant nature of cellulosic wastes. In this study, an active, structurally stable mesophilic lignocellulolytic degrading microbial consortium (Np-LMC) was constructed from forest compost soil microbiota by successive subcultivation on Napier grass under facultative anoxic conditions. According to tagged 16S rRNA gene amplicon sequencing, increasing abundance of facultative Proteobacteria was found in the middle of batch cycle which was then subsequently replaced by the cellulose degraders Firmicutes and Bacteroidetes along with decreasing CMCase, xylanase, and β-glucanase activity profiles in the supernatant after 5 days of incubation...
November 20, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29159778/risk-of-leptomeningeal-carcinomatosis-in-patients-with-brain-metastases-treated-with-stereotactic-radiosurgery
#7
Rosaline Ma, Morgan Levy, Bin Gui, Shou-En Lu, Venkat Narra, Sharad Goyal, Shabbar Danish, Simon Hanft, Atif J Khan, Jyoti Malhotra, Sabin Motwani, Salma K Jabbour
There is limited available literature examining factors that predispose patients to the development of LMC after stereotactic radiosurgery (SRS) for brain metastases. We sought to evaluate risk factors that may predispose patients to LMC after SRS treatment in this case-control study of patients with brain metastases who underwent single-fraction SRS between 2011 and 2016. Demographic and clinical information were collected retrospectively for 19 LMC cases and 30 controls out of 413 screened patients with brain metastases...
November 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29138187/roundup-from-lmc-conference
#8
Gareth Iacobucci
No abstract text is available yet for this article.
November 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29124751/detailed-characterization-of-human-mycobacterium-tuberculosis-specific-hla-e-restricted-cd8-t-cells
#9
Teresa Prezzemolo, Krista E van Meijgaarden, Kees Lmc Franken, Nadia Caccamo, Francesco Dieli, Tom Hm Ottenhoff, Simone A Joosten
HLA-E presented antigens are interesting targets for vaccination given HLA-Es' essentially monomorphic nature. We have shown previously that Mycobacterium tuberculosis (Mtb) peptides are presented by HLA-E to CD8(+) effector T-cells, but the precise phenotype and functional capacity of these cells remains poorly characterized. We have developed and utilized in this study a new protocol combining HLA-E tetramer with intracellular staining for cytokines, transcription factors and cytotoxic molecules to characterize these cells in depth...
November 9, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29097289/assessment-of-self-management-in-patients-with-diabetes-using-the-novel-lmc-skills-confidence-and-preparedness-index-scpi
#10
Ronnie Aronson, Ruth E Brown, Dishay Jiandani, Ashleigh Walker, Naomi Orzech, Lawrence Mbuagbaw
AIMS: The LMC Skills, Confidence & Preparedness Index (SCPI) is an electronic tool designed to meet ISOQOL standards and (a) assess three dimensions: knowledge, confidence and preparedness; (b) provide a clinically meaningful measure; (c) provide immediate feedback to the healthcare provider. Internal consistency and external validity have been previously reported in a refractory diabetes cohort. This larger evaluation, broader in glycemic control, sought to assess clinical relevance to glycemia...
October 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29069594/columnar-intrinsic-cues-shape-premotor-input-specificity-in-locomotor-circuits
#11
Myungin Baek, Chiara Pivetta, Jeh-Ping Liu, Silvia Arber, Jeremy S Dasen
Control of movement relies on the ability of circuits within the spinal cord to establish connections with specific subtypes of motor neuron (MN). Although the pattern of output from locomotor networks can be influenced by MN position and identity, whether MNs exert an instructive role in shaping synaptic specificity within the spinal cord is unclear. We show that Hox transcription-factor-dependent programs in MNs are essential in establishing the central pattern of connectivity within the ventral spinal cord...
October 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/29061638/motor-neurons-with-limb-innervating-character-in-the-cervical-spinal-cord-are-sculpted-by-apoptosis-based-on-the-hox-code-in-chick-embryo
#12
Katsuki Mukaigasa, Chie Sakuma, Tomoaki Okada, Shunsaku Homma, Takako Shimada, Keiji Nishiyama, Noboru Sato, Hiroyuki Yaginuma
In the developing chick embryo, a certain population of motor neurons (MNs) in the non-limb-innervating cervical spinal cord undergoes apoptosis between embryonic days 4 and 5. However, the characteristics of these apoptotic MNs remain undefined. Here, by examining the spatiotemporal profiles of apoptosis and MN subtype marker expression in normal or apoptosis-inhibited chick embryos, we found that this apoptotic population is distinguishable by Foxp1 expression. When apoptosis was inhibited, the survived Foxp1+ MNs showed characteristics of lateral motor column (LMC) neurons, which are of a limb-innervating subtype, suggesting that cervical Foxp1(+) MNs are the rostral continuation of LMC...
October 23, 2017: Development
https://www.readbyqxmd.com/read/28949349/understanding-the-structure-and-reactivity-of-nicu-nanoparticles-an-atomistic-model
#13
P Quaino, G Belletti, S A Shermukhamedov, D V Glukhov, E Santos, W Schmickler, R Nazmutdinov
The structure of bimetallic NiCu nanoparticles (NP) is investigated as a function of their composition and size by means of Lattice MonteCarlo (LMC) and molecular dynamics (MD) simulations. According to our results, copper segregation takes place at any composition of the particles. We found that this feature is not size-dependent. In contrast, nickel segregation depends on the NP size. When the size increases, Ni atoms tend to remain in the vicinity of the surface and deeper. For smaller NPs, Ni atoms are located at the surface as well...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28924004/basic-fibroblast-growth-factor-2-is-a-determinant-of-cd4-t-cell-airway-smooth-muscle-cell-communication-through-membrane-conduits
#14
Soroor Farahnak, Toby K McGovern, Rachael Kim, Michael O'Sullivan, Brian Chen, Minhyoung Lee, Haruka Yoshie, Anna Wang, Joyce Jang, Saba Al Heialy, Anne-Marie Lauzon, James G Martin
Activated CD4 T cells connect to airway smooth muscle cells (ASMCs) in vitro via lymphocyte-derived membrane conduits (LMCs) structurally similar to membrane nanotubes with unknown intercellular signals triggering their formation. We examined the structure and function of CD4 T cell-derived LMCs, and we established a role for ASMC-derived basic fibroblast growth factor 2 (FGF2b) and FGF receptor (FGFR)1 in LMC formation. Blocking FGF2b's synthesis and FGFR1 function reduced LMC formation. Mitochondrial flux from ASMCs to T cells was partially FGF2b and FGFR1 dependent...
November 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28881814/diagnostic-and-prognostic-values-of-cerebrospinal-fluid-cyfra-21-1-in-patients-with-leptomeningeal-carcinomatosis
#15
Jae-Won Hyun, Ji Hyun Park, Boo Gil Kang, Eun Young Park, Boram Park, Jungnam Joo, Jong Kuk Kim, Su-Hyun Kim, Jee Hyang Jeong, Hyang Woon Lee, Kee Duk Park, Kyung Gyu Choi, Sang-Hyun Hwang, Ho-Shin Gwak, Ho Jin Kim
OBJECTIVES: To investigate the diagnostic and prognostic values of cerebrospinal fluid (CSF) CYFRA 21-1 in patients with leptomeningeal carcinomatosis (LMC). METHODS: Concentration of CSF CYFRA 21-1 was detected using electro-chemiluminescent immunoassay. The difference in level of CYFRA 21-1 between 61 patients with LMC and 200 patients with other neurological disease was evaluated, and diagnostic performance of CSF CYFRA 21-1 was investigated. In LMC patients treated with ventriculo-lumbar perfusion (VLP) chemotherapy, prognostic performance of CSF CYFRA 21-1 was evaluated...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881161/leptomeningeal-carcinomatosis-from-gastric-cancer-successfully-treated-by-the-intrathecal-methotrexate-plus-temozolomide-and-simultaneous-radiotherapy-case-report-and-literatures-review
#16
Yangyang Liu
Leptomeningeal carcinomatosis (LMC) from gastrointestinal cancer is rare. A 56-year-old man with complaint of upper abdominal pain exhibited adenocarcinoma upon histopathologic examination of biopsy specimens. At the end of adjuvant chemotherapy, the patient was affected by hearing loss. Malignant cells were observed by cerebrospinal fluid (CSF) cytology. Therefore, the patient received intrathecal methotrexate and oral temozolomide chemotherapy and radiotherapy. The progress-free survival was approximately 11 months...
October 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28830129/genome-re-sequencing-to-identify-snp-markers-for-muscle-color-traits-in-broiler-chickens
#17
Hyeonmin R Kong, Nicholas B Anthony, Kaylee C Rowland, Bhuwan Khatri, Byungwhi C Kong
Objective: Meat quality including muscle color in chickens is an important trait and continuous selective pressures for fast growth and high yield have negatively impacted this trait. This study was conducted to investigate genetic variations responsible for regulating muscle color. Methods: Whole genome re-sequencing analysis using Illumina HiSeq paired end read method was performed with pooled DNA samples isolated from two broiler chicken lines divergently selected for muscle color [high muscle color (HMC) and low muscle color (LMC)] along with their random bred control line (RAN)...
August 22, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28813804/leap-motion-evaluation-for-assessment-of-upper-limb-motor-skills-in-parkinson-s-disease
#18
A H Butt, E Rovini, C Dolciotti, P Bongioanni, G De Petris, F Cavallo
The main goal of this study is to investigate the potential of the Leap Motion Controller (LMC) for the objective assessment of motor dysfunctioning in patients with Parkinson's disease (PwPD). The most relevant clinical signs in Parkinson's Disease (PD), such as slowness of movements, frequency variation, amplitude variation, and speed, were extracted from the recorded LMC data. Data were clinically quantified using the LMC software development kit (SDK). In this study, 16 PwPD subjects and 12 control healthy subjects were involved...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28802401/differences-in-igg-responses-against-infection-phase-related-mycobacterium-tuberculosis-mtb-specific-antigens-in-individuals-exposed-or-not-to-mtb-correlate-with-control-of-tb-infection-and-progression
#19
Mariateresa Coppola, Leonar Arroyo, Krista E van Meijgaarden, Kees Lmc Franken, Annemieke Geluk, Luis F Barrera, Tom H M Ottenhoff
Tuberculosis (TB) occurs in only 3-10% of Mycobacterium tuberculosis (Mtb) infected individuals, suggesting that natural immunity can contain Mtb infection, although this remains poorly understood. Next to T-cells, a potentially protective role for B-cells and antibodies has emerged recently. However, the Mtb antigens involved remain ill-defined. Here, we investigated in a TB-endemic setting IgG levels against 15 Mtb antigens, representing various phases of Mtb infection and known to be potent human T-cell antigens...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28757287/sagittal-lumbopelvic-alignment-in-patients-with-low-back-pain-and-the-effects-of-a-high-load-lifting-exercise-and-individualized-low-load-motor-control-exercises-a-randomized-controlled-trial
#20
Lars Berglund, Björn Aasa, Peter Michaelson, Ulrika Aasa
BACKGROUND CONTEXT: Assessment of posture and lumbopelvic alignment is often the main focus in the classification and treatment of patients with low back pain (LBP). However, little is known regarding the effects of motor control interventions on objective measures of lumbopelvic alignment. PURPOSE: The primary aim of this study was to describe the variation of sagittal lumbopelvic alignment in patients with nociceptive mechanical LBP. The secondary aim was to compare the effects of a high-load lifting exercise (HLL) and low-load motor control exercises (LMC) on the change in lumbopelvic alignment with a special emphasis on patients with high and low degrees of lumbar lordosis (lu) and sacral angle (sa)...
July 28, 2017: Spine Journal: Official Journal of the North American Spine Society
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