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https://www.readbyqxmd.com/read/29049530/risk-of-venous-thromboembolism-among-otolaryngology-patients-vs-general-surgery-and-plastic-surgery-patients
#1
John D Cramer, Amanda E Dilger, Alex Schneider, Stephanie Shintani Smith, Sandeep Samant, Urjeet A Patel
Importance: Venous thromboembolism (VTE), which includes deep venous thrombosis or pulmonary embolism, is the number 1 cause of preventable death in surgical patients. Current guidelines from the American College of Chest Physicians provide VTE prevention recommendations that are specific to individual surgical subspecialties; however, no guidelines exist for otolaryngology. Objective: To examine the rate of VTE for various otolaryngology procedures compared with an established average-risk field (general surgery) and low-risk field (plastic surgery)...
October 19, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29049269/long-term-surgical-outcomes-after-early-definitive-spinal-fusion-for-early-onset-scoliosis-with-neurofibromatosis-type-1-at-mean-follow-up-of-14-years
#2
Ryoji Tauchi, Noriaki Kawakami, Michael Anton Castro, Tetsuya Ohara, Toshiki Saito, Kazuaki Morishita, Ippei Yamauchi
BACKGROUND: Several authors mentioned surgical outcome for scoliosis associated with neurofibromatosis type 1 (NF-1). However, no studies have summarized long-term surgical outcomes after surgical treatment of early-onset scoliosis (EOS) with NF-1. The purpose of this study is to evaluate the long-term surgical outcome after early definitive spinal fusion for EOS in NF-1 patients. METHODS: We performed a retrospective review on a cohort of 11 patients diagnosed with EOS associated with NF-1 between 1990 and 2009 in our hospital...
October 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29046796/pulmonary-and-pleural-metastasis-of-intracranial-anaplastic-meningioma-in-a-3-year-old-boy-a-case-report
#3
Yuko Honda, Rie Shirayama, Hiromi Morita, Koichi Kusuhara
In adults, meningiomas occasionally display aggressive behavior and may occasionally metastasize. By contrast, pediatric meningiomas are rare, and there is limited information regarding their clinical characteristics, treatment and prognosis. We herein report the case of a 3-year-old boy with anaplastic meningioma with a history of local recurrence and late pulmonary metastasis. At diagnosis, a 70-mm mass lesion in was identified in the right frontal lobe, with intratumoral hemorrhage. The tumor was attached to the falx cerebri and was completely resected...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29045502/long-term-toxicity-of-cisplatin-in-germ-cell-tumor-survivors
#4
M Chovanec, M Abu Zaid, N Hanna, N El-Kouri, L H Einhorn, C Albany
Context: Testicular germ cell tumors (GCT) are highly curable. A multidisciplinary approach, including cisplatin-based chemotherapy has resulted in cure in the majority of patients with GCT. Thus, the life expectancy of survivors will extend to many decades post diagnosis. Late treatment toxicities associated with cisplatin-based chemotherapy may impact their future health. Objective: To systematically evaluate evidence regarding the long-term toxicity of cisplatin in GCT survivors...
July 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044995/mir-200c-regulates-endothelin-1-induced-pasmcs-abnormal-proliferation-and-apoptosis
#5
Chao Yuan, Min Xu, Rong Rong, Yong Mei, Wenyan Cai, Lin Li, Yao Xue, Baoli Zhu, Kai Sun, Lei Han
miR-200c is an antioncogene in multiple tumors. However, its function in the pathogenesis of pulmonary arterial hypertension (PAH) has not been thoroughly investigated nor understood. In this study, we discovered that miR-200c was able to substantially upregulate in pulmonary arterial smooth muscle cells (PASMCs) treated with endothelin-1 (ET-1). miR-200c also induced cell proliferation and suppressed cell apoptosis in PASMCs in vitro. However, miR-200c had no effect on G1/S/G2 transitions during the cell cycle...
October 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/29043206/spontaneous-regression-of-a-pulmonary-adenocarcinoma-after-core-needle-biopsy
#6
Cristiana Marques, Henrique Queiroga, Margarida Marques, Conceição Moura
Spontaneous regression (SR) of cancer, especially lung cancer, is a rare biological event with a mechanism that is not currently understood. Immunological mechanisms seem to be the stronger explanation in SR of a lung cancer. We report the rare case of SR of a lung adenocarcinoma stage IA, in a 75-year-old man, which was incidentally diagnosed and histologically confirmed. Due to the patient's comorbidities and his poor pulmonary function, stereotactic radiotherapy was scheduled. However, by the time the treatment was due to start, the tumor was no longer detectable...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29042934/intermittent-hypoxia-simulating-obstructive-sleep-apnea-causes-pulmonary-inflammation-and-activates-the-nrf2-ho-1-pathway
#7
Yeying Wang, Yanling Chai, Xiaojie He, Li Ai, Xia Sun, Yiling Huang, Yongxia Li
Obstructive sleep apnea (OSA) is a disorder with high morbidity in adults. OSA damages multiple organs and tissues, including the cardiovascular and cerebrovascular systems, the metabolism system, the lungs, liver and heart. OSA-induced damage is earliest and greatest to the pulmonary tissue. The present study established a rat OSA model of differing severity by inducing intermittent hypoxia with different concentrations of O2 and it was determined that OSA caused a severe oxidative stress response and pulmonary inflammation in a dose-dependent manner...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042417/restoration-of-natural-killer-cell-anti-metastatic-activity-by-il-12-and-checkpoint-blockade
#8
Isabel Ohs, Laura Ducimetiere, Joana Marinho, Paulina Kulig, Burkhard Becher, Sonia Tugues
Immune checkpoint therapies target tumor antigen-specific T cells, but less is known about their effects on natural killer (NK) cells, which help control metastasis. In studying the development of lung metastases, we found that NK cells lose their cytotoxic capacity and acquire a molecular signature defined by the expression of co-inhibitory receptors. In an effort to overcome this suppressive mechanism, we evaluated NK cell responses to the immunostimulatory cytokine IL-12. Exposure to IL-12 rescued the cytotoxicity of NK cells but also led to the emergence of an immature NK cell population which expressed high levels of the co-inhibitory molecules PD-1, Lag-3 and TIGIT, thereby limiting NK cell-mediated control of pulmonary metastases...
October 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/29042049/t-category-of-non-small-cell-lung-cancer-invading-the-fissure-to-the-adjacent-lobe
#9
Ming Liu, Dennis Wigle, Jason A Wampfler, Jie Dai, Shawn M Stoddard, Zhiqiang Xue, Francis C Nichols, Gening Jiang, Ping Yang
BACKGROUND: Dispute arises in the tumor category of non-small cell lung cancer invading the fissure to the adjacent lobe. The purpose of this study is to determine the long-term prognosis of non-small cell lung cancer with such an invasion and to propose an appropriate T category. METHODS: In total, 53 cases of non-small cell lung cancer invading the fissure to the adjacent lobe (fissure group) were identified in patients who underwent pulmonary resection from 1997 to 2014...
November 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29039495/protective-effects-of-neem-azadirachta-indica-a-juss-leaf-extract-against-cigarette-smoke-and-lipopolysaccharide-induced-pulmonary-inflammation
#10
Jae-Won Lee, Hyung Won Ryu, So-Yeon Park, Hyun Ah Park, Ok-Kyoung Kwon, Heung Joo Yuk, Krishna K Shrestha, Minwoo Park, Jung Hee Kim, Sangwoo Lee, Sei-Ryang Oh, Kyung-Seop Ahn
Neem (Azadirachta indica A. Juss.) leaf has been reported to exert anti-inflammatory, antibacterial and antioxidant effects. The purpose of this study was to investigate the protective effects of neem leaf extract (NLE) against cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with NLE significantly attenuated the infiltration of inflammatory cells, such as neutrophils and macrophages in bronchoalveolar lavage fluid (BALF). NLE also reduced the production of reactive oxygen species and the activity of neutrophil elastase in BALF...
October 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29039444/vaspin-protects-against-lps%C3%A2-induced-ards-by-inhibiting-inflammation-apoptosis-and-reactive-oxygen-species-generation-in-pulmonary-endothelial-cells-via-the-akt-gsk%C3%A2-3%C3%AE-pathway
#11
Di Qi, Daoxin Wang, Chunrong Zhang, Xumao Tang, Jing He, Yan Zhao, Wang Deng, Xinyu Deng
Acute respiratory distress syndrome (ARDS) is characterized by uncontrolled extravasation of protein‑rich fluids, which is caused by disruption and dysfunction of the barrier of pulmonary endothelial cells (ECs). Visceral adipose tissue‑derived serine protease inhibitor (vaspin) is a novel adipokine with pleiotropic properties, which has been reported to exert beneficial effects against obesity‑associated systemic vascular diseases; however, its effects on ARDS remain unknown. In the present study, mice were subjected to systemic administration of adenoviral vector expressing vaspin (Ad‑vaspin) to examine its effects on lipopolysaccharide (LPS)‑induced ARDS in vivo...
October 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29039075/venous-thromboembolism-and-intracranial-hemorrhage-after-craniotomy-for-primary-malignant-brain-tumors-a-national-surgical-quality-improvement-program-analysis
#12
Joeky T Senders, Nicole H Goldhaber, David J Cote, Ivo S Muskens, Hassan Y Dawood, Filip Y F L De Vos, William B Gormley, Timothy R Smith, Marike L D Broekman
Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), frequently complicates the postoperative course of primary malignant brain tumor patients. Thromboprophylactic anticoagulation is commonly used to prevent VTE at the risk of intracranial hemorrhage (ICH). We extracted all patients who underwent craniotomy for a primary malignant brain tumor from the National Surgical Quality Improvement Program (NSQIP) registry (2005-2015) to perform a time-to-event analysis and identify relevant predictors of DVT, PE, and ICH within 30 days after surgery...
October 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29038921/muscular-sarcoidosis-involving-the-chest-and-abdominal-walls-case-report-with-mr-imaging
#13
Seunghyun Lee, In Sook Lee, Jeongha Mok, You Seon Song, Kyung-Un Choi
Sarcoidosis is an inflammatory disorder that is characterized by the presence of noncaseating granulomas in tissues, involving many organs and tissues. Extra-pulmonary, especially muscular sarcoidosis is a rare condition. The most common location of the muscular sarcoidosis is known to be the proximal muscles of the extremities; however, there have been no cases of diffuse involvement of the chest and abdominal wall muscles. Here, we report a rare muscular sarcoidosis with infiltrative pattern in the chest and abdominal wall muscles and describe the MR imaging findings that were mistaken as lymphoma at initial diagnosis...
October 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29038780/pulmonary-ossification-and-microlithiasis-in-a-bitch-with-multicentric-mammary-tumors
#14
Mahir A G Kubba
Microliths and ossification were found in the lungs of a 12-year-old bitch suffering from compound mammary gland tumor which has disseminated in the inguinal lymph node glands and the lungs. Pulmonary ossification appeared grossly as irregular stony sharp particles which infiltrated the lung tissue and were readily recognizable from under the pleura as grayish sharp protruding particles. Microscopic examination revealed the existence of intra-alveolar single or multilobular particles of ossification which are formed of lamellated osseous substance with osteocytes in lacunae...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29038249/anti-pd-1-antibody-treatment-promotes-clearance-of-persistent-cryptococcal-lung-infection-in-mice
#15
Jonathan A Roussey, Steven P Viglianti, Seagal Teitz-Tennenbaum, Michal A Olszewski, John J Osterholzer
Activation of immunomodulatory pathways in response to invasive fungi can impair clearance and promote persistent infections. The programmed cell death protein-1 (PD-1) signaling pathway inhibits immune effector responses against tumors, and immune checkpoint inhibitors that block this pathway are being increasingly used as cancer therapy. The objective of this study was to investigate whether this pathway contributes to persistent fungal infection and to determine whether anti-PD-1 Ab treatment improves fungal clearance...
October 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29037039/synthesis-and-preclinical-evaluation-of-18f-peg3-fpn-for-the-detection-of-metastatic-pigmented-melanoma
#16
Xiaodong Xu, Lujie Yuan, Lianglan Yin, Yaqun Jiang, Yongkang Gai, Qingyao Liu, Yichun Wang, Yongxue Zhang, Xiaoli Lan
Although 18F-5-fluoro-N-(2-[diethylamino]ethyl)picolinamide (18F-5-FPN) is considered a promising radiopharmaceutical for PET imaging of melanoma, it accumulates at high concentrations in the liver. The aim in this research was to optimize the structure of 18F-5-FPN with triethylene glycol to reduce liver uptake as well as improve pharmacokinetics, and to evaluate its performance in detection of melanoma liver and lung metastases. 18F-PEG3-FPN was successfully prepared with a high radiolabeling yield (44.68% ± 5...
October 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29036520/lung-specific-overexpression-of-constitutively-active-ikk2-induces-pulmonary-and-systemic-inflammations-but-not-hypothalamic-inflammation-and-glucose-intolerance
#17
Minjie Chen, Huifen Zhou, Yanyi Xu, Lianglin Qiu, Ziying Hu, Xiaobo Qin, Sufang Chen, Yuhao Zhang, Qi Cao, Yousef Abu-Amer, Zhekang Ying
The lung is constantly exposed to ambient pollutants such as ambient fine particulate matter (PM2.5), making it one of the most frequent locations of inflammation in the body. Given the establishment of crucial role of inflammation in the pathogenesis of cardiometabolic diseases, pulmonary inflammation is thus widely believed to be an important risk factor for cardiometabolic diseases. However, the causality between them has not yet been well established. To determine if pulmonary inflammation is sufficient to cause adverse cardiometabolic effects, SFTPC-rtTA+/-tetO-cre+/-pROSA-inhibitor κB kinase 2(IKK2)ca+/- (LungIKK2ca) and littermate SFTPC-rtTA+/-tetO-cre-/-pROSA-IKK2ca+/- wildtype (WT) mice were fed with doxycycline diet to induce constitutively active Ikk2 (Ikk2ca) overexpression in the lung and their pulmonary, systemic, adipose, and hypothalamic inflammations, vascular function, and glucose homeostasis were assessed...
July 28, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29035996/radioguided-occult-lesion-localization-technical-procedures-and-clinical-applications
#18
Gianpiero Manca, Sara Mazzarri, Domenico Rubello, Elisa Tardelli, Roberto C Delgado-Bolton, Francesco Giammarile, Manuela Roncella, Duccio Volterrani, Patrick M Colletti
PURPOSE: Regarding radioguided surgery, the concept of "radioguided occult lesion localization" (ROLL) is based on both preoperative interventional imaging and intraoperative radioguided detection of a clinically occult neoplastic lesion. METHODS: This methodology consists in the direct administration into the lesion of Tc-macroaggregated human albumin formed by relatively large particles retained at the injection site, which direct radioguided excisional biopsy...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29033202/-pyopneumothorax-in-rheumatoid-arthritis
#19
B Huret, S Boulanger, L Benhamed, X Deprez, D Caparros
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the joints but which frequently includes extra articular effects, including pulmonary nodules, which grow faster under immunosuppressive treatment. CASE REPORT: A 74 years old man, with mild asbestosis, underwent treatment with methotrexate then leflunomide (LEF) for seropositive RA. In February 2014, during monitoring of his asbestosis, chest CT scan showed the appearance of thick-walled cavitating lung nodules, with a central and sub pleural distribution...
October 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29032404/dietary-supplementation-with-methylseleninic-acid-inhibits-mammary-tumorigenesis-and-metastasis-in-male-mmtv-pymt-mice
#20
Sneha Sundaram, Lin Yan
Male breast cancer, which makes up approximately 1% of all breast cancers, is an aggressive disease with poor prognosis. We investigated the effects of dietary supplementation with selenium in the form of methylseleninic acid [(MSeA) 2.5 mg selenium/kg] on mammary tumorigenesis in male MMTV-PyMT mice. The mammary tumor latency was 14.6 weeks for the MSeA-fed group and 13.8 weeks for the controls fed the AIN93G diet (p < 0.05). Dietary supplementation with MSeA, versus the control, resulted in a 72% reduction in tumor progression, a 46% reduction in both final volume and weight of mammary tumors, and a 70% reduction in the number of lung metastases...
October 14, 2017: Biological Trace Element Research
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