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https://www.readbyqxmd.com/read/29928985/design-and-characterization-of-emulsified-spray-dried-alginate-microparticles-as-a-carrier-for-the-dually-acting-drug-roflumilast
#1
Azza A Mahmoud, Nermeen A Elkasabgy, Abdel Fatah A Abdelkhalek
Roflumilast is a selective inhibitor of phosphodiesterase-4 isoenzyme in lung cells. Having psychiatric adverse reactions when administered orally affects negatively the patients' adherence to the drug. This work aimed to prepare emulsified spray dried alginate microparticles for the pulmonary delivery of roflumilast. Sodium alginate was used as microparticle-forming material, isopropyl myristate as an oil, Tween®80 as surfactant and calcium beta-glycerophosphate as cross-linking agent to enhance the mechanical properties of the particles...
June 18, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29928211/small-cell-carcinoma-transformation-of-pulmonary-adenocarcinoma-after-osimertinib-treatment-a-case-report
#2
Yuri Taniguchi, Hajime Horiuchi, Teppei Morikawa, Kazuhiro Usui
There are various mechanisms underlying the resistance of EGFR-mutant lung adenocarcinoma to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). We herein report a case of pulmonary adenocarcinoma with EGFR mutation (exon 19 deletion and T790M) that acquired resistance to osimertinib treatment because of transformation into small-cell lung carcinoma (SCLC). A 67-year-old ex-smoking woman was diagnosed with left upper lobe adenocarcinoma of clinical stage IIIA (cT2bN2M0). She was treated with chemoradiotherapy (cisplatin and vinorelbine plus radiation), gefitinib, cisplatin, and pemetrexed followed by pemetrexed maintenance therapy and erlotinib...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29927042/lung-resident-natural-killer-cells-control-pulmonary-tumor-growth-in-mice
#3
Yutaka Yamamoto, Kiho Miyazato, Kei Takahashi, Naoki Yoshimura, Hideaki Tahara, Yoshihiro Hayakawa
Accumulating evidences indicate an importance of NK cells in controlling tumor growth and metastasis. NK cell subsets display diversities in their function and tissue distribution and Mac-1hi CD27lo NK cells are the predominant population of lung-resident NK cells. Although lung is a major organ where primary tumor develops and cancer cells metastasizes, there is no clear evidence whether circulating NK cells and/or tissue-resident NK cells control tumor growth in lung. In this study, we examined an anti-tumor function of lung-resident NK cells to control pulmonary tumor growth...
June 21, 2018: Cancer Science
https://www.readbyqxmd.com/read/29926548/bleomycin-inhibits-proliferation-via-schlafen-mediated-cell-cycle-arrest-in-mouse-alveolar-epithelial-cells
#4
Soojin Jang, Se Min Ryu, Jooyeon Lee, Hanbyeol Lee, Seok Ho Hong, Kwon Soo Ha, Won Sun Park, Eun Taek Han, Se Ran Yang
BACKGROUND: Idiopathic pulmonary fibrosis involves irreversible alveolar destruction. Although alveolar epithelial type II cells are key functional participants within the lung parenchyma, how epithelial cells are affected upon bleomycin (BLM) exposure remains unknown. In this study, we determined whether BLM could induce cell cycle arrest via regulation of Schlafen (SLFN) family genes, a group of cell cycle regulators known to mediate growth-inhibitory responses and apoptosis in alveolar epithelial type II cells...
June 19, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29926010/pulmonary-tumor-thrombotic-microangiopathy-induced-by-prostate-cancer
#5
Satoshi Katayama, Tadasu Takenaka, Aya Nakamura, Sinichi Sako, Akihiro Bessho, Nobuya Ohara
Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal, malignancy-related respiratory complication; we herein report a PTTM case induced by metastatic prostate cancer. An 81-year-old Japanese man developed dyspnea. High-resolution computed tomography (HRCT) revealed ground-glass opacities spread across bilateral lung fields. Pulmonary microvascular aspiration cytology detected prostate cancer cells. As PTTM was highly suspected, docetaxel chemotherapy was performed immediately. His respiratory condition and HRCT findings improved temporarily, but he died approx...
June 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29925295/a-case-report-pharmacology-and-resistance-patterns-of-three-generations-of-alk-inhibitors-in-metastatic-inflammatory-myofibroblastic-sarcoma
#6
Barbara M Parker, John V Parker, Anastasios Lymperopoulos, Vijay Konda
Background Little exists currently in research about the mechanisms of resistance of ALK inhibitors in inflammatory myofibroblastic sarcoma. It is known, however, that ALK gene rearrangements are common in inflammatory myofibroblastic tumors, similar to non-small cell lung cancer. In roughly 50% of inflammatory myofibroblastic tumors, gene rearrangement has been found to occur on chromosome 2 at band 2p23. In non-small cell lung cancer, it has been shown that about a third of patients who progress on the first generation ALK inhibitor, crizotinib develops mutations in the ALK kinase domain...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29924283/-tuberculosis-that-mimics-cancer-cases-referred-to-the-national-institute-of-neoplastic-diseases-lima-peru
#7
Juliana R Villena-Suarez, William Vicente, Luis Taxa, Luis Cuéllar, Maria T Nuñez-Butrón, Valeria Villegas, Miluska Castillo, Carlos A Castañeda
Tuberculosis (TB) is a major public health problem that, due to the clinical variability of its presentation, can be confused with cancer. The aim of this study was to identify the clinical-radiological characteristics and to describe the methodology that allowed to achieve a TB diagnosis in patients referred to the National Institute of Neoplastic Diseases (INEN) with a presumed diagnosis of cancer between 2014 and 2016. The study included 170 patients (52.4% men) with an average age of 41.1 years; 18% presented a history of contact with TB, and 5...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29924239/tuberous-sclerosis-complex-review-based-on-new-diagnostic-criteria
#8
Larissa Karine Leite Portocarrero, Klícia Novais Quental, Luciana Paula Samorano, Zilda Najjar Prado de Oliveira, Maria Cecília da Matta Rivitti-Machado
Tuberous sclerosis complex is a multisystemic, autosomal dominant genetic disorder with complete penetrance, that can evolve with hamartomas in multiple organs, such as skin, central nervous system, kidney and lung. Due to the wide phenotypic variability, the disease is often not recognized. Tuberous sclerosis complex affects one in 10,000 newborns and most patients are diagnosed during the first 15 months of life. The diagnostic criteria for tuberous sclerosis were reviewed in 2012, at the second International Tuberous Sclerosis Complex Consensus Conference...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924023/small-cell-lung-cancer-mimicking-lymphoma-in-ct-and-68ga-dota-noc-pet-ct-a-case-report
#9
Liyan Lu, Fengfang Li, Yamei Zhang, Peng Wang, Xindao Yin, Wenbin Li
RATIONALE: Small cell lung cancer accounts for 15-20% of all lung cancers and is the most common pulmonary neuroendocrine neoplasm. Most small cell lung cancers arise from lobar or main bronchi, the most common manifestations of small cell lung cancer is a large mass centrally located within the lung parenchyma or a mediastinal mass involving the hilus. Small cell lung cancer is easily ignored by clinicians without lung parenchyma and hilus involvement. Here, we report a case of small cell lung cancer, which was misdiagnosed as the lymphoma in contrast enhanced CT and Ga-DOTA-NOC PET/CT imagings...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924006/radiologic-findings-of-primary-pulmonary-angiosarcoma-a-case-report
#10
Jianbing Ma, Weiqiang Zhang, Yijuan Huang, Lizhang Wang, Jia Wang, Linna Yuan, Jingfeng Zhang
RATIONALE: Primary pulmonary angiosarcoma is a rare disease. Here, we report the case of primary pulmonary angiosarcoma diagnosed computed tomographic pulmonary angiography (CTPA) and discuss its specific imaging characteristics. PATIENT CONCERNS: A 46-year-old man was admitted for cough and shortness of breath. Thoracic CTPA images demonstrated a high-attenuation lesion surrounding by a halo sign in upper lobe of right lung, and the dilated vessel was also seen in lower lobe of right lung...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29922942/validating-margin-status-in-lung-wedge-resection-for-clinical-stage-i-non-small-cell-lung-cancer
#11
Noriyoshi Sawabata, Akikazu Kawase, Nobumasa Takahashi, Takeshi Kawaguchi, Tetsukan Woo, Yuichi Saito, Satoshi Shiono, Noriyuki Matsutani
Stage I non-small cell lung cancer (NSCLC) is a localized disease without metastasis; therefore, it can be treated effectively with local therapies. Pulmonary resection is the most frequent treatment, performed as pulmonary wedge resection, segmentectomy, lobectomy, or pneumonectomy. Some retrospective clinical studies of pulmonary wedge resection suggest that its outcome may be inferior to that of anatomical pulmonary resection, whereas other recent studies, which assess surgical margin status, leveled acceptable outcomes...
June 19, 2018: Surgery Today
https://www.readbyqxmd.com/read/29916548/methylation-profiles-of-mir34-gene-family-in-vietnamese-patients-suffering-from-breast-and-lung-cancers
#12
Vo Thi Thuong Lan, Ho Van Son, Vu Lan Trang, Nguyen Thu Trang, Nguyen Thi Phuong, Nguyen Linh Toan, Pham Anh Thuy Duong
The three genes encoding small non‑coding microRNA (miR)34a, MIR34b and MIR34c act as tumor‑suppressor genes. Their aberrant expressions regulated by DNA methylation have been frequently found in various types of cancer. In the present study, the DNA promoter methylation profiles of the MIR34 gene family were analyzed using the methylation specific polymerase chain reaction in order to clarify their association with breast and lung cancer, non‑cancerous or normal adjacent tissues. The methylation frequency of MIR34a was significantly higher in breast cancer (49...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916529/wnt-inhibitory-factor-1-mediated-autophagy-inhibits-wnt-%C3%AE-catenin-signaling-by-downregulating-dishevelled-2-expression-in-non-small-cell-lung-cancer-cells
#13
Xinmei Luo, Sujuan Ye, Qianqian Jiang, Yi Gong, Yue Yuan, Xueting Hu, Xiaolan Su, Wen Zhu
Wnt inhibitory factor‑1 (WIF‑1) is an important antagonist of Wnt/β‑catenin signaling by binding to Wnt ligands. The downregulation of WIF‑1 leads to the development of non‑small cell lung cancer (NSCLC). The upregulation of WIF‑1 significantly inhibits proliferation and induces apoptosis by inhibiting Wnt/β‑catenin signaling in NSCLC. However, the mechanisms underlying the inhibition of Wnt/β‑catenin signaling by WIF‑1‑mediated autophagy are poorly understood. Thus, in this study, we aimed to shed some light into these mechanisms...
June 15, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29915309/cxcr1-akt-signaling-activation-induced-by-mesenchymal-stem-cell-derived-il-8-promotes-osteosarcoma-cell-anoikis-resistance-and-pulmonary-metastasis
#14
Lin Du, Xiu-Guo Han, Bing Tu, Min-Qi Wang, Han Qiao, Shu-Hong Zhang, Qi-Ming Fan, Ting-Ting Tang
The loss of appropriate cell adhesion normally induces apoptosis via a process termed anoikis. The aim of this study was to investigate the effects of mesenchymal stem cells (MSCs) in the cancer microenvironment on the anoikis resistance and pulmonary metastasis of osteosarcoma (OS) cells, and to evaluate the critical role of the interleukin (IL)-8/C-X-C chemokine receptor (CXCR) 1/Akt-signaling pathway in these processes. Metastatic OS subtype cells, which did or did not interact with MSC-conditioned medium (MSC-CM) in vitro, were isolated from the pulmonary site and named Saos2-lung-M...
June 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29912718/pulmonary-sarcomatoid-carcinomas-a-review
#15
Annikka Weissferdt
Pulmonary sarcomatoid carcinomas belong to a group of neoplasms that remain incompletely understood. They are rare tumors of the bronchopulmonary system that incorporate a wide range of neoplasms that by definition contain a sarcomatoid component characterized by spindle or giant cells. Such classification has led to a heterogenous tumor category that includes neoplasms with different clinical, morphologic, and prognostic features. To date, the histopathologic diagnosis of pulmonary sarcomatoid carcinomas does not require the use of ancillary testing and is based on light microscopic criteria alone...
June 15, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29910732/bleomycin-aggravates-atopic-dermatitis-via-lung-inflammation-in-2-4-dinitrochlorobenzene-induced-nc-nga-mice
#16
Yoon-Young Sung, Seung-Hyung Kim, Won-Kyung Yang, Yang-Chun Park, Ho Kyoung Kim
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Bleomycin (BLM) contributes to the induction of pulmonary inflammation and fibrosis in animals. Although skin and lung tissue inflammation is closely related in the pathogenesis of allergic diseases, a proper animal model for investigating the relationship between skin and lung inflammation is lacking. Therefore, we developed a mouse model of AD with relapsing dermatitis and pulmonary fibrosis caused by the administration of allergen and BLM. The present study determined whether lung injury caused by the bronchial application of BLM would exacerbate AD-like allergic inflammation induced by 2, 4-dinitrochlorobenzene (DNCB) in NC/Nga mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29909079/primary-pulmonary-giant-cell-tumor
#17
Sara Pabón-Carrasco, Ana María Vallejo-Benitez, Manuel Pabón-Carrasco, Enrique Rodriguez-Zarco
No abstract text is available yet for this article.
June 13, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29908980/incidence-and-prognostic-significance-of-carcinoid-lymph-node-metastases
#18
Peter J Kneuertz, Mohamed K Kamel, Brendon M Stiles, Benjamin E Lee, Mohamed Rahouma, Sebron W Harrison, Nasser K Altorki, Jeffery L Port
BACKGROUND: Pulmonary carcinoid tumors are often considered indolent tumors. The prognostic significance of lymph node (LN) metastases and the need for mediastinal dissection is controversial. We sought to determine the incidence, risk factors, and prognosis of LN metastases in resected carcinoid patients. METHODS: Patients undergoing lung resection for carcinoid and removal of ≥10 LNs were identified in the National Cancer Database form 2004-2014. Typical (TC) and atypical (AC) carcinoids were included...
June 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29908246/refractory-ceramic-fibers-fiber-characteristics-potential-health-effects-and-clinical-observations
#19
Mark J Utell, L Daniel Maxim
Refractory ceramic fibers (RCFs) are amorphous fibers that belong to a class of materials termed synthetic vitreous fibers (SVFs), also called man-made mineral fibers (MMMFs), which includes alkaline earth silicate wool, glass wool, rock (stone) wool, slag wool, and special-purpose glass fibers. RCFs are more durable and biopersistent than several other SVFs, although very much less biopersistent than either amosite or crocidolite asbestos. Chronic inhalation studies indicated that rats and hamsters exposed to RCF fibers developed fibrosis and tumors...
June 13, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29907082/paravertebral-dexmedetomidine-as-an-adjuvant-to-ropivacaine-protects-against-independent-lung-injury-during-one-lung-ventilation-a-preliminary-randomized-clinical-trial
#20
Wei Zhang, Shanfeng Zhang, Bing Li, Mingyang Sun, Jiaqiang Zhang
BACKGROUND: To investigate the effect of paravertebral dexmedetomidine as an adjuvant to ropivacaine on independent lung injury during one-lung ventilation. METHODS: In total, 120 patients who underwent elective radical resection of pulmonary carcinoma were randomly assigned to one of six groups (n = 20): normal saline (C group), ropivacaine (R group), intravenous dexmedetomidine (Div group), 0.5 μg/kg paravertebral dexmedetomidine as an adjuvant to ropivacaine (RD0...
June 15, 2018: BMC Anesthesiology
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