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https://www.readbyqxmd.com/read/29454048/new-insights-into-the-molecular-characteristics-of-pulmonary-carcinoids-and-large-cell-neuroendocrine-carcinomas-and-the-impact-on-their-clinical-management
#1
REVIEW
J L Derks, N Leblay, S Lantuejoul, A M Dingemans, E J M Speel, L Fernandez-Cuesta
Carcinoids and large-cell neuroendocrine carcinomas (LCNEC) are rare neuroendocrine lung tumors. Here we provide an overview of the most updated data on the molecular characteristics of these diseases. Recent genomic studies showed that carcinoids generally contain a low mutational burden and few recurrently mutated genes. Most of the reported mutations occur in chromatin-remodeling genes (e.g. MEN1), and few affect genes of the PI3K-AKT-mTOR pathway. Aggressive disease has been related to chromothripsis, DNA-repair gene mutations, loss of OTP/CD44, and upregulation of RET gene expression...
February 14, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29453962/an-autoantibody-against-human-dna-topoiomerase-i-is-a-novel-biomarker-for-non-small-cell-lung-cancer
#2
Wen-Bin Wu, Shang-Mian Yie, Shang-Rong Ye, Ke Xie, Jian-Bo Zhang, Mei Cao, Jie Chen, Xu He, Xiao-Li Ma, Jia Zhang
BACKGROUND: We previously reported a novel tumor associated antigen with a molecular weight around 48 kDa that was a fragment derived from human DNA-topoiomerase I. The aim of this study is to further investigate the clinical significance of the autoantibody in patients with non-small cell lung cancer (NSCLC). METHODS: We determined serum levels of the autoantibody in 127 NSCLC patients, 127 age-, gender- and smoking history-matched healthy controls, and 38 patients with pulmonary benign tumors by using a specific enzyme linked immunosorbent assay (ELISA) for the autoantibody...
February 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29452998/resection-of-intrathoracic-paraganglioma-with-and-without-cardiopulmonary-bypass
#3
Carmelina Gurrieri, James J Butz, Toby N Weingarten, Irina Bancos, William F Young, Stephen D Cassivi, Sameh M Said, Travis J McKenzie, David W Barbara, Juraj Sprung
BACKGROUND: Intrathoracic paragangliomas (PGLs) are rare tumors. Approximately 50% originate from and around cardiac structures. METHODS: A retrospective review was made of the perioperative course of patients with intrathoracic PGL resection from 2000 through 2015 at Mayo Clinic in Rochester, Minnesota. RESULTS: Twenty-two patients underwent PGL resection. Sixteen patients (73%) had functioning tumors (11, noradrenergic; 4, mixed noradrenergic and dopaminergic; 1, dopaminergic)...
February 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29451347/a-rare-case-of-ectopic-papillary-thyroid-carcinoma-transformed-into-squamous-cell-carcinoma
#4
Hironao Yasuoka, Yasushi Nakamura, Ken-Ichi Yoshida, Toshiro Shimo, Masayuki Tori, Yuuki Matsui, Yasushi Sakamaki, Masahiko Tsujimoto
A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. During the post-operative follow-up period, a rapidly growing 2 cm nodular lesion in the lower left lobe of the lung was detected...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29449935/pleomorphic-liposarcoma-of-bone-a-rare-primary-malignant-bone-tumour
#5
G L Tiemeier, J M Brown, S E Pratap, C McCarthy, A Kastrenopoulou, K Bradley, S Wilson, Z Orosz, C L M H Gibbons, U Oppermann, N A Athanasou
Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29448832/bland-or-tumor-pulmonary-artery-stump-thrombosis
#6
Luis Gorospe, Raquel Jover-Díaz, Gemma María Muñoz-Molina
No abstract text is available yet for this article.
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29445589/robot-assisted-bronchoplasty-using-continuous-barbed-sutures
#7
Omar Matthieu Sarsam, Joel Dunning, Bruno Pochulu, Jean-Marc Baste
We describe in this article our bronchoplastic robot-assisted techniques. This consists of using continuous barbed sutures. Our aim is to show the feasibility and the interest of using robotics and this kind of suture material for complex bronchial procedures. We report four cases in France and the UK, two wedge bronchoplasties and two sleeve bronchoplasties for central pulmonary tumors.
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29445486/aneurysm-of-the-inferior-vena-cava-with-thrombosis
#8
Masashi Inoue, Takeshi Sudo, Megumi Yamaguchi, Shingo Seo, Tatsuya Miyamoto, Toshihiro Misumi, Wataru Shimizu, Toshimitsu Irei, Takahisa Suzuki, Takashi Onoe, Yosuke Shimizu, Takao Hinoi, Hirotaka Tashiro
Inferior vena cava (IVC) aneurysms are extremely rare. Patients can be asymptomatic, have thrombosis, rupture, or pulmonary embolism. Thrombosis of the IVC aneurysm may mimic a retroperitoneal tumor. Surgical treatment of abdominal venous aneurysms with thrombosis is warranted and is necessary for the management of intraoperative bleeding and thrombosis.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29445290/molecular-features-of-giant-cell-carcinoma-of-the-lung-a-case-report-and-literature-review
#9
Xin Li, Zihe Zhang, Jinghao Liu, Dan Wang, Sen Wei, Jun Chen
Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper lobe of his lung. After thoracoscopic lobectomy, a histopathologic diagnosis of GCCL was made. He did well postoperatively, showing no local recurrence or distal disease in a 7-year follow-up period...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29444773/lung-function-inflammation-and-endothelin-1-in-congenital-heart-disease-associated-pulmonary-arterial-hypertension
#10
Andrew Low, Sarah George, Luke Howard, Nicholas Bell, Ann Millar, Robert M R Tulloh
BACKGROUND: Breathlessness is the most common symptom in people with pulmonary arterial hypertension and congenital heart disease (CHD-APAH), previously thought to be caused by worsening PAH, but perhaps also by inflammation and abnormalities of lung function. We studied lung function and airway inflammation in patients with CHD-APAH and compared the results with controls. METHODS AND RESULTS: Sixty people were recruited into the study: 20 CHD-APAH, 20 CHD controls, and 20 healthy controls...
February 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29443743/circulating-mir-146a-b-correlates-with-inflammatory-cytokines-in-copd-and-could-predict-the-risk-of-acute-exacerbation-copd
#11
Bei-Bei Chen, Zhen-Hua Li, Shan Gao
The aim of this study was to investigate the predicting value of miR-146a/b for acute exacerbation chronic obstructive pulmonary disease (AECOPD) and COPD, and to explore their associations with inflammatory cytokines in AECOPD and stable COPD patients.One hundred six AECOPD, 122 stable COPD patients, and 110 health volunteers with age and sex matched to total COPD patients (AECOPD and stable COPD) were enrolled. Blood samples were collected from all participants. Relative expression of miR-146a/b was determined by real-time polymerase chain reaction...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443539/intermittent-exposure-to-cigarette-smoke-increases-lung-tumors-and-the-severity-of-emphysema-more-than-continuous-exposure
#12
Naofumi Kameyama, Shotaro Chubachi, Ahmed E Hegab, Hiroyuki Yasuda, Shizuko Kagawa, Akihiro Tsutsumi, Koichi Fukunaga, Masayuki Shimoda, Yae Kanai, Kenzo Soejima, Tomoko Betsuyaku
Lung cancer and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality worldwide, and cigarette smoking is a main risk factor for both. The presence of emphysema, an irreversible lung disease, further raises the risk of lung cancer in COPD patients. The mechanisms involved in smoke-induced tumorigenesis and emphysema are not fully understood, attributable to a lack of appropriate animal models. Here, we optimized a model of cigarette smoke (CS)-induced lung cancer and emphysema in A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent carcinogen...
February 14, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29442347/f-18-fdg-pet-ct-in-pulmonary-artery-sarcoma-clinical-vignette
#13
Stjepan Hmelik, Margareta Dobrenić, Dražen Huić
Pulmonary artery sarcomas (PAS's) are extremely rare malignant tumors that arise from the endothelial lining of the pulmonary arteries. On CT scans PAS's appear as intraluminal filling defects in the pulmonary arteries, mimicking pulmonary embolism (PE). Due to the similarities in radiographic features as well as in clinical presentation, PAS's are usually misdiagnosed as pulmonary embolism. Since PASs are F-18 FDG avid, F-18 FDG PET/CT scan is a useful imaging tool for differentiating between these two conditions, as shown in this case report...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29442198/hgf-reduces-disease-severity-and-inflammation-by-attenuating-the-nf-%C3%AE%C2%BAb-signaling-in-a-rat-model-of-pulmonary-artery-hypertension
#14
Ying Pang, Ming-Ting Liang, Ying Gong, Yong Yang, Pei-Li Bu, Mei Zhang, Heng-Chen Yao
The purpose of the present study was to investigate the anti-inflammatory effect of hepatocyte growth factor (HGF) on pulmonary artery hypertension (PAH) in a rat model and underlying mechanisms. Wistar rats were treated with monocrotaline intravenously to induce PAH and then treated with vehicle or HGF for 2 weeks, respectively. The mean pulmonary artery pressure (mPAP), the index of right heart ventricular hypertrophy (RHVI), pathological changes, and inflammation in the lungs of individual rats were measured...
February 13, 2018: Inflammation
https://www.readbyqxmd.com/read/29441326/a-rare-case-of-primary-intrapulmonary-neurilemmoma-diagnosed-in-a-43-year-old-asymptomatic-man-with-a-well-defined-intrapulmonary-mass
#15
Serafeim Chrysikos, Maria Kaponi, Christina Triantafillidou, Theodoros Karampitsakos, Argyrios Tzouvelekis, Maria Anyfanti, Konstantinos Marossis, Marios Konstantinou, Rodoula Tringidou, Demosthenes Bouros, Katerina Dimakou
Neurilemmoma (NL), also termed schwannoma, presents as a well-circumscribed and encapsulated mass in the human body and is almost always solitary. CT scan of a patient with NL shows a round, ovoid, or lobulated well-demarcated solid mass of soft tissue density. Primary intrathoracic neurogenic tumors location varies. However, the development of such tumors is by far more common in the costovertebral angle of the posterior mediastinum. Here, we report a rare case of a 43-year-old patient, never smoker and previously healthy, who presented with a mass adjacent to the right pulmonary hilum...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29441110/case-of-mucinous-adenocarcinoma-of-the-lung-associated-with-congenital-pulmonary-airway-malformation-in-a-neonate
#16
Juneyoug Koh, Euiseok Jung, Se Jin Jang, Dong Kwan Kim, Byong Sop Lee, Ki-Soo Kim, Ellen Ai-Rhan Kim
Congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation, is a rare developmental lung abnormality associated with rhabdomyosarcoma, pleuropulmonary blastoma, and mucinous adenocarcinoma of the lung. We report an unusual case of a 10-day-old male newborn with a left lower lobe pulmonary cyst who underwent lobectomy, which revealed type II CPAM complicated by multifocal mucinous adenocarcinoma. KRAS sequencing revealed a somatic mutation in Codon12 (GGT → GAT), suggesting the development of a mucinous adenocarcinoma in the background of mucinous metaplasia...
January 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29438170/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-dipnech-syndrome-and-carcinoid-tumors-with-without-nech-a-clinicopathologic-radiologic-and-immunomolecular-comparison-study
#17
Maria Cecilia Mengoli, Giulio Rossi, Alberto Cavazza, Renato Franco, Federica Zito Marino, Mario Migaldi, Letizia Gnetti, Enrico Maria Silini, Luca Ampollini, Marcello Tiseo, Filippo Lococo, Ludovic Fournel, Paolo Spagnolo, Vincent Cottin, Thomas V Colby
The diagnostic criteria of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) are not well defined, and DIPNECH can be mistaken for carcinoids associated with neuroendocrine cell hyperplasia (NECH). In this study, we compared clinical, radiologic, histologic, immunohistochemical, and molecular features of DIPNECH and isolated carcinoids with/without NECH. The study population included 151 cases (77 female patients and 74 male patients), 19 with DIPNECH and 132 with carcinoids with/without NECH...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29437031/underexpression-of-mir-486-5p-but-not-overexpression-of-mir-155-is-associated-with-lung-cancer-stages
#18
Marwa A Mohamed, Ehab I Mohamed, Samir A Abd El-Kaream, Mohamed I Badawi, Samy H Darwish
BACKGROUND: Evidence is increasing that microRNAs (miR) are particularly important in lung homeostasis and development and have been shown to be involved in many pulmonary diseases such as asthma, chronic obstructive pulmonary disease, sarcoidosis, lung cancer (LC) and other smoking-related diseases. OBJECTIVE: The objective of this study was to investigate the expression of miR-155 and miR-486-5p in tissues from LC patients and healthy endobronchial mucosa as prognostic biomarkers for diagnosing LC...
February 12, 2018: MicroRNA
https://www.readbyqxmd.com/read/29436921/volumetric-and-linear-measurements-of-lung-tumor-burden-from-non-gated-micro-ct-imaging-correlate-with-histological-analysis-in-a-genetically-engineered-mouse-model-of-non-small-cell-lung-cancer
#19
Aitor Gallastegui, James Cheung, Teresa Southard, Kelly R Hume
In vivo micro-computed tomography (CT) imaging allows longitudinal studies of pulmonary neoplasms in genetically engineered mouse models. Respiratory gating increases the accuracy of lung tumor measurements but lengthens anesthesia time in animals that may be at increased risk for complications. We hypothesized that semiautomated, volumetric, and linear tumor measurements performed in micro-CT images from non-gated scans would have correlation with histological findings. Primary lung tumors were induced in eight FVB mice with two transgenes (FVB/N-Tg(tetO-Kras2)12Hev/J; FVB...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29435191/effect-of-postoperative-systemic-therapy-on-pulmonary-adenocarcinoma-with-unexpected-pleural-spread-detected-during-thoracotomy-or-thoracoscopy
#20
Chi-Lu Chiang, Lei-Chi Wang, Hsiang-Ling Ho, Chun-Ming Tsai, Yi-Chen Yeh, Wen-Hu Hsu, Teh-Ying Chou, Chao-Hua Chiu, Yu-Chung Wu
Background: Occasionally, malignant pleural disease is only detected unexpectedly during surgery in patients with pulmonary adenocarcinoma. Previous studies mostly focused on the role of main tumor resection on patient's outcome, barely addressing the position of postoperative systemic therapy. Methods: The medical records of 5321 non-small cell lung cancer patients who underwent thoracic surgery between January 1990 and December 2012 were reviewed. Pulmonary adenocarcinoma patients with unexpected pleural spread noted during surgery were included...
January 12, 2018: Oncotarget
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