Mengnan Liu, Gang Yuan, Gang Luo, Xin Guo, Mingtai Chen, Huayi Yang, Fan He, Tingfu Yang, Xinyue Zhang, Qibiao Wu, Hua Zhou, Sijin Yang
Background: Danshen Decoction comprises Salvia miltiorrhiza , Santalum album , and Amomum villosum . It can promote blood circulation and remove blood stasis, and is commonly used in the treatment of gastric and duodenal ulcers, coronary heart disease, angina pectoris, etc. This research is based on network pharmacology and is experimentally verified to explore the potential mechanism of Danshen Decoction in the treatment of ischemic cardiomyopathy (ICM). Methods: The effective components and targets of Danshen Decoction were firstly extracted from Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform, the drug-component-target-disease network was then constructed, the protein-protein interaction (PPI) network was constructed, the Gene Ontology (GO) enrichment analysis was carried out, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway was analyzed in order to find the potential active components and therapeutic mechanisms...
2022: Evidence-based Complementary and Alternative Medicine: ECAM