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https://www.readbyqxmd.com/read/28431420/generative-retrieval-improves-learning-and-retention-of-cardiac-anatomy-using-transesophageal-echocardiography
#1
Amanda M Kleiman, Katherine T Forkin, Allison J Bechtel, Stephen R Collins, Jennie Z Ma, Edward C Nemergut, Julie L Huffmyer
BACKGROUND: Transesophageal echocardiography (TEE) is a valuable monitor for patients undergoing cardiac and noncardiac surgery as it allows for evaluation of cardiovascular compromise in the perioperative period. It is challenging for anesthesiology residents and medical students to learn to use and interpret TEE in the clinical environment. A critical component of learning to use and interpret TEE is a strong grasp of normal cardiovascular ultrasound anatomy. METHODS: Fifteen fourth-year medical students and 15 post-graduate year (PGY) 1 and 2 anesthesiology residents without prior training in cardiac anesthesia or TEE viewed normal cardiovascular anatomy TEE video clips; participants were randomized to learning cardiac anatomy in generative retrieval (GR) and standard practice (SP) groups...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28431097/on-the-appropriate-interpretation-of-evidence-the-example-of-culture-media-and-birth-weight
#2
Stephen A Roberts, Andy Vail
No abstract text is available yet for this article.
April 19, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28431035/medical-symptom-validity-test-performance-following-moderate-severe-traumatic-brain-injury-expectations-based-on-orientation-log-classification
#3
Stephen N Macciocchi, Ronald T Seel, Angela Yi, Sarah Small
Objective: This study examined performance on the Medical Symptom Validity test (MSVT) during acute rehabilitation for moderate-severe traumatic brain injury (TBI) stratified by Orientation Log (O-Log) scores. Method: Participants were 77 prospectively enrolled persons who sustained moderate-severe TBI and were acutely hospitalized secondary to the cognitive, medical and physical sequelae of their TBI. Participants were administered neuropsychological metrics, the O-Log and the MSVT a mean of 44 days post injury...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28431030/using-multivariate-base-rates-to-interpret-low-scores-on-an-abbreviated-battery-of-the-delis-kaplan-executive-function-system
#4
Justin E Karr, Mauricio A Garcia-Barrera, James A Holdnack, Grant L Iverson
Objective: Executive function consists of multiple cognitive processes that operate as an interactive system to produce volitional goal-oriented behavior, governed in large part by frontal microstructural and physiological networks. Identification of deficits in executive function in those with neurological or psychiatric conditions can be difficult because the normal variation in executive function test scores, in healthy adults when multiple tests are used, is largely unknown. This study addresses that gap in the literature by examining the prevalence of low scores on a brief battery of executive function tests...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28431029/the-chinese-version-of-the-brief-assessment-of-cognition-in-schizophrenia-data-of-a-large-scale-mandarin-speaking-population
#5
Liang-Jen Wang, Yu-Chi Huang, Chi-Fa Hung, Chih-Ken Chen, Yi-Chih Chen, Pei-Yi Lee, Si-Ming Wang, Ming-Hsiung Liu, Chia-Ju Lin, Su-Ting Hsu
Objective: The Brief Assessment of Cognition in Schizophrenia (BACS) is a cognitive assessment tool used to measure the broad aspects of cognition that are most frequently impaired in patients with schizophrenia. This study aims to develop the normative data of the Chinese version of the BACS among the Mandarin-speaking population. Method: This cross-sectional study included 382 healthy participants (age range: 19-79 years; mean age: 48.0 ± 16.7 years, 47.6% men) in Taiwan, who were evaluated with the BACS...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28430971/association-between-native-american-owned-casinos-and-the-prevalence-of-large-for-gestational-age-births
#6
Jessica C Jones-Smith, William H Dow, Vanessa M Oddo
Background: A small number of studies have used a natural experiment approach to examine the health impacts of increased economic resources stemming from Native American-owned casinos. We build on this work by examining whether casinos are associated with obesity-related health in utero . Methods: We examined whether casino openings or expansion (as proxy for increased economic resources) are associated with a decreased likelihood of infants being born large-for-gestational-age (LGA), an important risk factor for childhood overweight/obesity...
April 19, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28430951/evidence-for-a-strong-correlation-between-transcription-factor-protein-disorder-and-organismic-complexity
#7
Inmaculada Yruela, Christopher J Oldfield, Karl J Niklas, A Keith Dunker
Studies of diverse phylogenetic lineages reveal that protein disorder increases in concert with organismic complexity but that differences nevertheless exist among lineages. To gain insight into this phenomenology, we analyzed all of the transcription factor (TF) families for which sequences are known for 17 species spanning bacteria, yeast, algae, land plants, and animals and for which the number of different cell types has been reported in the primary literature. Although the fraction of disordered residues in TF sequences is often moderately or poorly correlated with organismic complexity as gauged by cell type number (r2 < 0...
April 18, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28430833/on-the-need-for-quantitative-bias-analysis-in-the-peer-review-process
#8
Matthew P Fox, Timothy L Lash
Peer review is central to the process through which epidemiologists generate evidence to inform public health and medical interventions. Reviewers thereby act as critical gatekeepers to high-quality research. They are asked to carefully consider the validity of the proposed work or research findings by paying careful attention to the methodology and critiquing the importance of the insight gained. However, although many have noted problems with the peer-review system for both manuscripts and grant submissions, few solutions have been proposed to improve the process...
April 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28430703/evidence-based-recommendations-for-pediatric-orthopaedic-practice
#9
Kishore Mulpuri, Emily K Schaeffer, H Kerr Graham, Mininder S Kocher, James Sanders, Ira Zaltz
BACKGROUND: Evidence-based medicine has become the cornerstone to guide clinical practice decision-making. Evidence-based medicine integrates the strongest available evidence with clinical expertise to make decisions about clinical care. The quality of the evidence depends upon the soundness of the study methodology to allow for meaningful interpretation of the clinical results. The purpose of this review is to analyze the methodological design and clinical findings of published pediatric orthopaedic studies to determine their ability to change or influence clinical practice...
April 20, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28430695/cerebral-recovery-index-reliable-help-for-prediction-of-neurologic-outcome-after-cardiac-arrest
#10
Marleen C Tjepkema-Cloostermans, Jeannette Hofmeijer, Albertus Beishuizen, Harold W Hom, Michiel J Blans, Frank H Bosch, Michel J A M van Putten
OBJECTIVE: Early electroencephalography measures contribute to outcome prediction of comatose patients after cardiac arrest. We present predictive values of a new cerebral recovery index, based on a combination of quantitative electroencephalography measures, extracted every hour, and combined by the use of a random forest classifier. DESIGN: Prospective observational cohort study. SETTING: Medical ICU of two large teaching hospitals in the Netherlands...
April 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28430532/overcoming-discourse-linking-difficulties-in-aphasia-the-case-of-clitic-pronouns
#11
Silvia Martínez-Ferreiro, Andrés Felipe Reyes, Roelien Bastiaanse
The present study aims to contribute to the ongoing discussion about the impact of discourse-linking deficits on the performance of individuals with aphasia by providing new data from a set of rarely investigated constructions: sentences in which a clitic pronoun coexists alongside with the full DP it agrees with. To do so, we use data of individuals with non-fluent aphasias who need to overcome the difficulties in direct object (accusative) clitic production. This results in overproduction of non-target clitic right dislocations (RDs) and clitic doubling (CD)...
April 21, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28430483/infrared-peak-splitting-from-phonon-localization-in-solid-hydrogen
#12
Ioan B Magdău, Graeme J Ackland
We show that the isotope effect leads to a completely different spectroscopic signal in hydrogen-deuterium mixtures, compared to pure elements that have the same crystal structure. This is particularly true for molecular vibrations, which are the main source of information about the structure of high-pressure hydrogen. Mass disorder breaks translational symmetry, meaning that vibrations are localized almost to single molecules, and are not zone-center phonons. In mixtures, each observable infrared (IR) peak corresponds to a collection of many such molecular vibrations, which have a distribution of frequencies depending on local environment...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430457/classical-spin-liquid-instability-driven-by-off-diagonal-exchange-in-strong-spin-orbit-magnets
#13
Ioannis Rousochatzakis, Natalia B Perkins
We show that the off-diagonal exchange anisotropy drives Mott insulators with strong spin-orbit coupling to a classical spin liquid regime, characterized by an infinite number of ground states and Ising variables living on closed or open strings. Depending on the sign of the anisotropy, quantum fluctuations either fail to lift the degeneracy down to very low temperatures, or select noncoplanar magnetic states with unconventional spin correlations. The results apply to all 2D and 3D tricoordinated materials with bond-directional anisotropy and provide a consistent interpretation of the suppression of the x-ray magnetic circular dichroism signal reported recently for β-Li_{2}IrO_{3} under pressure...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430426/the-rosetta-all-atom-energy-function-for-macromolecular-modeling-and-design
#14
Rebecca Faye Alford, Andrew Leaver-Fay, Jeliazko R Jeliazkov, Matthew J O'Meara, Frank P DiMaio, Hahnbeom Park, Maxim V Shapovalov, P Douglas Renfrew, Vikram Khipple Mulligan, Kalli Kappel, Jason W Labonte, Michael Steven Pacella, Richard Bonneau, Philip Bradley, Roland L Dunbrack, Rhiju Das, David Baker, Brian Kuhlman, Tanja Kortemme, Jeffrey J Gray
Over the past decade, the Rosetta biomolecular modeling suite has informed diverse biological questions and engineering challenges ranging from interpretation of low-resolution structural data to design of nanomaterials, protein therapeutics, and vaccines. Central to Rosetta's success is the energy function: a model parameterized from small molecule and X-ray crystal structure data used to approximate the energy associated with each biomolecule conformation. This paper describes the mathematical models and physical concepts that underlie the latest Rosetta Energy Function, REF15...
April 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28430041/integrative-modeling-of-pfc
#15
William H Alexander, Eliana Vassena, James Deraeve, Zachary D Langford
pFC is generally regarded as a region critical for abstract reasoning and high-level cognitive behaviors. As such, it has become the focus of intense research involving a wide variety of subdisciplines of neuroscience and employing a diverse range of methods. However, even as the amount of data on pFC has increased exponentially, it appears that progress toward understanding the general function of the region across a broad array of contexts has not kept pace. Effects observed in pFC are legion, and their interpretations are generally informed by a particular perspective or methodology with little regard with how those effects may apply more broadly...
April 21, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28430031/evaluation-of-multidimensional-models-of-wais-iv-subtest-performance
#16
Dennis J McFarland
OBJECTIVE: The present study examined the extent to which the covariance structure of the WAIS-IV is best accounted for by models that assume that test performance is the result of group-level factors and multiple independent general factors. METHOD: Structural models with one to four general factors were evaluated with either four or five group-level factors. Simulations based on four general factors were run to clarify the adequacy of the estimates of the allocation of covariance by the models...
April 21, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28430009/evaluating-questionnaires-used-to-assess-self-reported-physical-activity-and-psychosocial-outcomes-among-survivors-of-adolescent-and-young-adult-cancer-a-cognitive-interview-study
#17
Amanda Wurz, Jennifer Brunet
Physical activity is increasingly being studied as a way to improve psychosocial outcomes (e.g., quality of life, self-efficacy, physical self-perceptions, self-esteem, body image, posttraumatic growth) among survivors of adolescent and young adult (AYA) cancer. Assessing levels of and associations between self-reported physical activity and psychosocial outcomes requires clear, appropriate, and relevant questionnaires. To explore how survivors of AYA cancer interpreted and responded to the following eight published questionnaires: Leisure Time Exercise Questionnaire, Exercise Self-Efficacy Scale, Physical Self-Description Questionnaire, Rosenberg Global Self-Esteem Scale, Multidimensional Body-Self Relations Questionnaire, Posttraumatic Growth Inventory, Functional Assessment of Cancer Therapy-General (FACT-G), RAND 36-Item Health Survey 1...
April 21, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28429996/are-athletes-doping-related-attitudes-predicted-by-their-perceptions-of-coaches-confrontation-efficacy
#18
Philip Sullivan, Parmida Razavi
BACKGROUND: The coaching process is complex and dynamic. Coaches are known to affect athlete attitudes indirectly, through athletes' perceptions and interpretations. This process has been verified with a variety of ethical behaviors. OBJECTIVES: The current study investigated the relationships between athletes' perceived doping confrontation efficacy of their coaches and athlete's anti-doping attitudes. METHODS: A sample of athletes (N = 96) completed a version of the Doping Confrontation Efficacy Scale that was modified to assess their perception of their coaches' anti-doping confrontation efficacy, and the PEAS (Performance Enhancing Attitude Scale), which assessed their performance-enhancing attitudes...
April 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28429943/on-the-size-and-origins-of-long-range-orientational-water-correlations-in-dilute-aqueous-salt-solutions
#19
Eva Pluharova, Damien Laage, Pavel Jungwirth
Long-range ordering of water around solutes has been invoked repeatedly in the literature as the key to understanding its biological function. Recently, it has been shown that in a dilute 8 mM aqueous NaCl solution the orientational correlation between water molecules extends beyond 8 nanometers. This was interpreted as arising from a long-range effect induced by the ions on the water collective hydrogen-bond interactions. Within this interpretation, each ion was supposed to affect tens of thousands or more water molecules in its surroundings, invoking a picture of ordered domains extending to several nanometers...
April 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28429938/high-resolution-accurate-mass-mass-spectrometry-enables-in-depth-characterization-of-in-vivo-biotransformations-for-intact-antibody-drug-conjugates
#20
Jintang He, Dian Su, Carl K Ng, Luna Liu, Shang-Fan Yu, Thomas H Pillow, Geoffrey Del Rosario, Martine Darwish, Byoung-Chul Lee, Rachana Ohri, Hongxiang Zhou, Xueji Wang, Jiawei Lu, Surinder Kaur, Keyang Xu
Antibody-drug conjugates (ADCs) represent a promising class of therapeutics for the targeted delivery of highly potent cytotoxic drugs to tumor cells to improve bioactivity while minimizing side effects. ADCs are composed of both small and large molecules, and therefore have complex molecular structures. In vivo biotransformations may further increase the complexity of ADCs, representing a unique challenge for bioanalytical assays. Quadrupole time-of-flight mass spectrometry (Q-TOF MS) with electrospray ionization has been widely used for characterization of intact ADCs...
April 21, 2017: Analytical Chemistry
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