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numb endometrial cancer

Stephanie M de Boer, Melanie E Powell, Linda Mileshkin, Dionyssios Katsaros, Paul Bessette, Christine Haie-Meder, Petronella B Ottevanger, Jonathan A Ledermann, Pearly Khaw, Alessandro Colombo, Anthony Fyles, Marie-Helene Baron, Henry C Kitchener, Hans W Nijman, Roy F Kruitwagen, Remi A Nout, Karen W Verhoeven-Adema, Vincent T Smit, Hein Putter, Carien L Creutzberg
BACKGROUND: About 15% of patients with endometrial cancer have high-risk features and are at increased risk of distant metastases and endometrial cancer-related death. We designed the PORTEC-3 trial to investigate the benefit of adjuvant chemoradiotherapy compared with radiotherapy alone for women with high-risk endometrial cancer. METHODS: PORTEC-3 was a multicentre, open-label, randomised, international trial. Women with high-risk endometrial cancer were randomly allocated (1:1) to radiotherapy alone (48·6 Gy) in 1·8 Gy fractions five times a week or chemoradiotherapy (two cycles concurrent cisplatin 50 mg/m(2) and four adjuvant cycles of carboplatin area under the curve [AUC] 5 and paclitaxel 175 mg/m(2)) using a biased coin minimisation procedure with stratification for participating centre, lymphadenectomy, stage of cancer, and histological type...
August 2016: Lancet Oncology
Chao Wang, Weiwei Feng, Chuyao Zhang
BACKGROUND: Since more and more evidences support that NUMB orchestrates many cell physiological and pathological processes of diseases including cancer, based on our previous work, we studied deeply the function of NUMB in endometrial cancer (EC) and tried to understand the mechanism of NUMB's nucleus translocation which might be relative to the occurrence of EC and will contribute to find a new targeting therapeutic strategy for EC. METHODS: Immunohistochemistry was employed to test NUMB and HDM2 expression in endometrial cancer tissue from clinical patients...
2015: Journal of Cancer
Hyo Sook Bae, Myong Cheol Lim, Jeong Seon Lee, Yumi Lee, Byung Ho Nam, Sang-Soo Seo, Sokbom Kang, Seung Hyun Chung, Joo-Young Kim, Sang-Yoon Park
PURPOSE: The goal of this study was to investigate clinical manifestations of lower extremity edema (LEE) after lymph node dissection in patients with primary endometrial cancer. METHODS: Women with primary endometrial cancer who underwent staging surgery between November 2001 and March 2011 were included in the study. Medical records and/or responses to the Gynecologic Cancer Lymphedema Questionnaire (GCLQ) were used for LEE evaluation. RESULTS: All 154 patients underwent pelvic lymph node dissection, and 126 patients (81...
January 2016: Annals of Surgical Oncology
Chao Wang, Tao Cui, Weiwei Feng, Huashun Li, Lina Hu
The cell fate determinant Numb orchestrates numerous cell physiological and pathological processes and previous evidence has indicated that Numb expression is associated with tumorigenesis. The present study investigated the potential role of Numb in endometrial cancer (EC). Numb expression was compared between the normal endometrium and EC tissue by immunohistochemistry, and the protein levels were assessed by western blotting and confocal microscopy in the human endometrial HEC-1B cancer cell line and normal epithelial cells...
April 2015: Oncology Letters
Hiroi Kaku, Seisuke Kumagai, Hiroki Onoue, Anna Takada, Tadahiro Shoji, Fumiharu Miura, Akira Yoshizaki, Shinya Sato, Junzo Kigawa, Tsutomu Arai, Shinpei Tsunoda, Eiichiro Tominaga, Daisuke Aoki, Toru Sugiyama
Paclitaxel/carboplatin chemotherapy for cancer (TC therapy) exhibits neurotoxicity and causes peripheral neuropathy at a high frequency, which is difficult to cope with. In this study, we investigated the efficacy of Goshajinkigan, a traditional Japanese herbal medicine, for TC therapy-induced peripheral neuropathy. The subjects included in our study were patients with ovarian or endometrial cancer who underwent TC therapy and developed peripheral neuropathy. The patients were randomly divided into Group A, comprising of 14 patients (vitamin B12 treatment), and Group B, comprising of 15 patients (vitamin B12 + Goshajinkigan treatment)...
January 2012: Experimental and Therapeutic Medicine
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