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numb cervical cancer

Elenaé Vázquez-Ulloa, Ana Clara Ramos-Cruz, Diddier Prada, Alejandro Avilés-Salas, Alma Delia Chávez-Blanco, Luis A Herrera, Marcela Lizano, Adriana Contreras-Paredes
The participation of NOTCH signaling in invasive cervical cancer (ICC) remains controversial since both tumor suppressive and oncogenic properties have been described. Additionally, the role of NUMB, a negative regulator of NOTCH, remains unclear in ICC. We aimed to investigate the role of NOTCH1 and NUMB expression and their localization in cervical intraepithelial neoplasia (CIN) and ICC samples. A total of 144 biopsies were obtained from the Instituto Nacional de Cancerología, México from 2004 to 2017, and were subjected to immunohistochemistry for NOTCH1 and NUMB...
April 10, 2018: Oncotarget
Linlin Jia, Fengying Li, Mingliang Shao, Wei Zhang, Chunbin Zhang, Xiaolian Zhao, Haiyan Luan, Yaling Qi, Pengxia Zhang, Lichun Liang, Xiuyue Jia, Kun Zhang, Yan Lu, Zhe Yang, Xiulin Zhu, Qi Zhang, Jiwei Du, Weiqun Wang
Interleukin-8 (IL-8) serves an important function in chronic inflammation and cancer development; however, the underlying molecular mechanism(s) of IL-8 in uterine cervical cancer remains unclear. The present study investigated whether IL-8 and its receptors [IL-8 receptor (IL-8R)A and IL-8RB] contributed to the proliferative and migratory abilities of HeLa cervical cancer cells, and also investigated the potential underlying molecular mechanisms. Results demonstrated that IL-8 and its receptors were detected in HeLa cells, and levels of IL-8RA were significantly increased compared with those of IL-8RB...
January 2018: Oncology Letters
Xiaoling Zhang, Xinyuan Li, Meihong Meng, Jie Cao, Xiaonan Song, Kangding Liu, Shaokuan Fang
RATIONALE: Superior vena cava syndrome (SVCS) is the obstruction of blood flow through the SVC, causing complete or partial blockade of the collateral circulation of returning venous blood. SVCS is frequently presented with facial, neck, trunk, and upper limbs swelling and so on. However, to the best of our knowledge, the obstruction of the venous return in the spinal veins is rarely a manifestation of SVCS. PATIENT CONCERNS: We presented a rare case of a 52-year-old male patient with 2-month history of progressive right upper limb numbness and swelling and 10-day history of extremities malfunctioning...
December 2017: Medicine (Baltimore)
Ping Dong, Ni Chen, Lin Li, Rui Huang
RATIONALE: The spine is the most common site of bone metastases due to thyroid cancer; however, spinal cord compression as a complication of metastatic thyroid cancer is very rare. PATIENT CONCERNS: A 48-year-old female patient was presented to the Neurosurgical Department, complaining of progressive back neck pain with bilateral upper extremities numbness and weakness for 4 months. DIAGNOSIS: Imaging studies revealed osteolytic destruction in bodies and accessories of the second and third cervical vertebrae with a huge soft-tissue mass compressing spinal cord and causing swelling...
October 2017: Medicine (Baltimore)
Guozi Yang, Zhenyu Pan, Ning Ma, Limei Qu, Tingting Yuan, Xiaochuan Pang, Xu Yang, Lihua Dong, Shixin Liu
Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and malignant form of lung cancer with a poor prognosis for patients. The common sites of metastases are the liver, adrenal glands, bone and brain. LCNEC rarely metastasizes to the small intestine, ovaries, tonsils, mandible, vulva or spine. To the best of our knowledge, there have been no reports of leptomeningeal metastasis of LCNEC to date. The present case report describes an unusual case of leptomeningeal metastasis from pulmonary LCNEC alongside a review of the literature...
October 2017: Oncology Letters
Cai Rong, Yu Feng, Zhou Ye
Cervical cancer, which is the second most common female malignancy, is characterized by the consistent presence of human papillomavirus. Inappropriate activation of Notch signaling has been associated with various types of cancer; however, the role of Notch in cervical cancer remains unclear. The present study aimed to investigate the role of Notch in cervical cancer. The methods used included the generation of plasmids, viability assays, polymerase chain reaction and western blotting The present findings demonstrated that cervical cancer samples also consistently exhibit abnormal activation of the Notch pathway...
April 2017: Oncology Letters
Hiromi Yasuda, Tadanobu Shimura, Masato Okigami, Shigeyuki Yoshiyama, Masaki Ohi, Koji Tanaka, Yasuhiko Mohri, Masato Kusunoki
A 63-year-old man visited the clinic with numbness in the right hand. Magnetic resonance imaging demonstrated multiple low-intensity lesions in the cervical vertebrae and sacrum, which was suspicious of cervical bone metastasis. Fluorodeoxyglucose positron emission tomography/computed tomography revealed areas of increased fluorodeoxyglucose uptake in the thoracic esophagus, sternum and sacrum. A flat, elevated esophageal cancer was identified by upper gastrointestinal endoscopy, and the macroscopic appearance indicated early-stage disease...
September 2016: Case Reports in Oncology
Je Hoon Jeong, Hee Kyung Kim, Soo Bin Im
BACKGROUND: Atlantoaxial spondyloarthropathy most often results from rheumatoid arthritis, cancer metastasis, or basilar invagination. Dialysis-related spondyloarthropathy is a rare cause of spinal deformity and cervical myelopathy at the atlantoaxial joint. We report 2 patients on long-term hemodialysis who presented with atlantoaxial spondyloarthropathy. CASE DESCRIPTION: Two patients with end-stage renal failure presented with a history of progressively worsening neck pain, motion limitation, and gait disturbance...
January 2017: World Neurosurgery
Takayuki Tajima, Masaya Mukai, Sayuri Hasegawa, Souichirou Yamamoto, Eiji Nomura, Takuma Tajiri, Sotaro Sadahiro, Seiei Yasuda, Hiroyasu Makuuchi
A 70-year-old man undergoing treatment for diabetes presented with a cough and pyrexia that has lasted one week. Laboratory tests demonstrated evidence of inflammation. The patient was hospitalized and antibiotic treatment was initiated, but the condition of the patient did not improve. After 2 weeks, computerized tomography scanning demonstrated the presence of multiple small nodules in the lungs and a liver abscess. The patient also developed neck pain and numbness of the upper extremities and was then transferred to Tokai University Hachioji Hospital (Tokyo, Japan)...
October 2015: Oncology Letters
Stepan Capek, Kimberly K Amrami, P James B Dyck, Robert J Spinner
OBJECT Nerve biopsy is typically performed in distal, noncritical sensory nerves without using imaging to target the more involved regions. The yield of these procedures rarely achieves more than 50%. In selected cases where preoperative evaluation points toward a more localized (usually a more proximal) process, targeted biopsy would likely capture the disease. Synthesis of data obtained from clinical examination, electrophysiological testing, and MRI allows biopsy of a portion of the major mixed nerves safely and efficiently...
September 2015: Neurosurgical Focus
Quirine D Pieterse, Gemma G Kenter, Cornelis P Maas, Cor D de Kroon, Carien L Creutzberg, J Baptist M Z Trimbos, Moniek M Ter Kuile
OBJECTIVE: Conventional radical hysterectomy with pelvic lymphadenectomy (RHL) for early-stage cervical cancer is associated with significant bladder, anorectal, and sexual dysfunction. Nerve-sparing modification of RHL (NS-RHL) has been developed with the aim to reduce surgical treatment-related morbidity. Postoperative radiation therapy (RT) is offered to patients with unfavorable prognostic features to improve local control. The aim of the study was to assess self-reported morbidity of various types of treatment in cervical cancer patients...
November 2013: International Journal of Gynecological Cancer
Peng-bo Deng, Yang-yang Luo, Cheng-ping Hu, Li-hua Zhou
OBJECTIVE: To further understand the clinical features and the causes of misdiagnosis of pancoast cancer. METHODS: The data of 26 cases of pancoast cancer from 1999 - 2006 were collected for a retrospective review. The clinical and imaging features, and the causes underlying misdiagnosis were analyzed. RESULTS: There were 24 males and 2 females (mean age 59 ± 6, range 44 - 70 years). The earliest clinical features of pancoast cancer included painful shoulder and back in 25 cases, upper extremity pain, palsy and numbness in 18 cases...
September 2011: Chinese Journal of Tuberculosis and Respiratory Diseases
Daniel Franzen, Tsogyal Latshang, Thomas Frauenfelder, Erich W Russi
A 37-years old patient of south Indian origin presented with pain in his right scapular region radiating to the right arm, numbness and muscular weakness of the fourth and fifth finger. Computed tomography (CT) revealed a mass at the right pleural dome with arrosion of the first rib (Pancoast presentation), an osteolytic process in the fourth rib and in the right hip. All three lesions had a high FDG uptake in the PET/CT suggestive for lung cancer metastases in this smoker. Surprisingly, the CT-guided fine needle biopsy revealed no malignancy, but granulomatous inflammation and epitheloid cells...
December 2010: Therapeutische Umschau. Revue Thérapeutique
Tomoyuki Kakuta, Shin-ichi Kosugi, Tatsuo Kanda, Katsuyoshi Hatakeyama
A 73-year-old man underwent neoadjuvant chemotherapy followed by transhiatal esophagectomy with gastric tube reconstruction for advanced esophageal cancer with palliative intent. Cervical esophagogastrostomy with circular-stapled end-to-side anastomosis was performed; however, anastomotic fistula developed. Fever, severe pain in the nape of the neck and numbness of the left hand were noted after drainage by wide opening of cervicotomy and the administration of empiric antibiotics. Magnetic resonance imaging revealed high signal intensity between the inferior C5 vertebral body and the intervertebral disc on T2-weighted images, and some areas were contrast-enhanced, suggesting purulent spondylodiscitis...
August 2010: Interactive Cardiovascular and Thoracic Surgery
Chao-Kai Hu, Lu-Ting Kuo, Wei-Chen Hong, Jen-Chieh Lee, Yong-Kwang Tu
STUDY DESIGN: Case report. OBJECTIVE: We report a rare case of postradiation sarcoma of the cervical spine 30 years after treatment for thyroid cancer. SUMMARY OF BACKGROUND DATA: The reported case is a 66-year-old man with a history of thyroid cancer treated with surgery and radiotherapy at the age of 36 years. He was disease-free for 30 years, but then developed left upper limb weakness and numbness. Magnetic resonance imaging showed a homogeneously enhanced mass lesion with cystic parts involving the C4 vertebral body and occupying the left side of the spinal canal with extension to the paraspinal space through the neural foramen...
April 20, 2010: Spine
C Marquart, M Weckesser, P Schueller, M Hasselblatt, H Wassmann, J Schröder
We report the rare case of a 74-year-old man who was admitted to our hospital with rapid progression of tetraparesis, which was most apparent in the lower right limb, sensory disturbances from C3 to S1 on the left side and recent onset of constipation and urinary retention. There was no known history of cancer. As MRI of the neck disclosed a cervical intramedullary mass lesion at C 4/5 level suspicious for a primary glial tumour, the patient underwent surgery. After microsurgical excision the histological analysis of the lesion unexpectedly revealed an intramedullary spinal cord metastasis (ISCM) of a poorly differentiated carcinoma, immunohistochemically consistent with a bronchial carcinoma...
November 2007: Zentralblatt Für Neurochirurgie
M Mohammadianpanah, M Vasei, A Mosalaei, S Omidvari, N Ahmadloo
Although it is quite rare, second primary neoplasms in cancer patients may present with the signs and symptoms of malignant spinal cord compression. Primary spinal cord tumours in the cancer patients may be deceptive and considered as the recurrent first cancer. Therefore, it should be precisely differentiated and appropriately managed. We report such a case of intramedullary ependymoma of the cervical spinal cord mimicking metatstatic recurrent lymphoma and causing cord compression. A 50-year-old man developed intramedullary ependymoma of the cervical spinal cord 1...
December 2006: European Journal of Cancer Care
Masuko Katoh, Masaru Katoh
Notch, FGF and WNT signaling pathways cross-talk during embryogenesis, tissue regeneration and carcinogenesis. Notch-ligand binding to Notch receptors leads to the cleavage of Notch receptors and the following nuclear translocation of Notch intracellular domain (NICD) to induce transcriptional activation of Notch target genes. Notch signaling inhibitors, NUMB and NUMB-like (NUMBL), are docking proteins with PTB domain. We searched for the TCF/LEF-binding site within the promoter region of NUMB and NUMBL genes...
September 2006: International Journal of Molecular Medicine
Tetsuro Inoue, Eisaku Tanaka, Minoru Sakuramoto, Masayoshi Minakuchi, Yuji Maeda, Ko Maniwa, Kunihiko Terada, Shunsuke Goto, Tomoshi Takeda, Yoshiaki Yuba, Yoichiro Kobashi, Satoshi Noma, Yoshio Taguchi
A 69-year-old woman was diagnosed with limited stage, small cell lung cancer in February 2001. Systemic chemotherapy and radiotherapy were performed resulting in complete remission of the disease. In October 2001, she complained of pain and numbness of her left arm. Magnetic resonance imaging (MRI) of the neck showed an intramedullary enhanced mass at the C4-5 level. Specimen obtained by tumor biopsy showed pathological diagnosis of metastasis from small cell lung cancer. Neurological symptoms improved after radiochemotherapy...
December 2004: Nihon Kokyūki Gakkai Zasshi, the Journal of the Japanese Respiratory Society
Michael Fredericson, Brandee L Waite
A 56-year-old woman with a chief complaint of left lower-extremity numbness was referred by her gynecologist to the physical medicine clinic for workup of presumed lumbosacral radiculopathy. She had no history of low back pain, and her symptoms were elicited only with exercise. Results of her neurologic examination and lumbosacral radiographs were normal. Her medical history was significant for advanced cervical cancer, successfully treated with local surgery followed by high-dose pelvic radiation and chemotherapy 2 years before the current onset of symptoms...
May 2003: Archives of Physical Medicine and Rehabilitation
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