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Keywords female reproductive system mal...

female reproductive system malignant tumors

https://read.qxmd.com/read/37716918/knockdown-of-limd2-inhibits-the-progression-of-ovarian-carcinoma-through-erk1-2-pathway
#21
JOURNAL ARTICLE
Haiyang Hu, Yanan Wang, Yan Dong, Lin Wang, Yahui Chen, Yan Zhou, Lin Sun
BACKGROUND: The incidence rate of ovarian carcinoma (OC) is the third of the female reproductive system malignant tumors, while its mortality rate ranks first among causes of female reproductive system tumor related death in the world. METHODS: In the present research, we investigated the specific role of LIMD2 through LIMD2 knockdown in OC cells. RESULTS: The results of online analysis and expression detection proved that LIMD2 was up-regulated in human OC tissues and cells...
September 16, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37702230/mitochondrial-calcium-uniporter-mcu-that-modulates-mitochondrial-calcium-uptake-and-facilitates-endometrial-cancer-progression-through-interaction-with-vdac1
#22
JOURNAL ARTICLE
Hongyan Xiao, Lijun Ma, Jie Ding, Honghong Wang, Xiaofang Bi, Fengmei Tan, Wenhua Piao
BACKGROUND: Although endometrial cancer represents a frequently diagnosed malignancy of the female reproductive tract, we know very little about the factors that control endometrial cancer. OBJECTIVE: Our study was presented to investigate the function of MCU in endometrial tumorigenesis and the molecular mechanisms involved. METHODS: A total of 94 endometrial cancer patients were recruited into our cohort. MCU and VDAC1 expression was examined in tumor and normal tissues via immunohistochemistry and immunofluorescence...
September 12, 2023: Current Cancer Drug Targets
https://read.qxmd.com/read/37690459/ct-based-radiomics-prediction-of-cxcl13-expression-in-ovarian-cancer
#23
JOURNAL ARTICLE
Wenting Xu, Chengyi Zhu, Dan Ji, Haiqing Qian, Lingli Shi, Xuping Mao, Huifang Zhou, Lihong Wang
BACKGROUND: Ovarian cancer, the most common malignancy in the female reproductive system, and patients tend to be at middle and advanced clinical stages when diagnosed. Therefore, early detection and early diagnosis have important clinical significance for the treatment of ovarian cancer patients. CXCL13, a chemokine with the ligands CXCR3 and CXCR5, is involved in the tumor metastasis process. PURPOSE: This study aimed to predict mRNA expression of CXCL13 in ovarian cancer tissues noninvasively...
September 10, 2023: Medical Physics
https://read.qxmd.com/read/37633972/mitophagy-related-long-non-coding-rna-signature-predicts-prognosis-and-drug-response-in-ovarian-cancer
#24
JOURNAL ARTICLE
Jiao Wang, Xiaocui Zhang, Fei Zheng, Qing Yang, Fangfang Bi
BACKGROUND: Ovarian cancer (OC) is the most malignant tumor with the worst prognosis in female reproductive system. Mitophagy and long non-coding RNAs (lncRNAs) play pivotal roles in tumorigenesis, development, and drug resistance. The effects of mitophagy-related lncRNAs on OC prognosis and therapeutic response remain unelucidated. METHODS: We retrieved OC-related RNA sequence, copy number variation, somatic mutation, and clinicopathological information from The Cancer Genome Atlas database and mitophagy-related gene sets from the Reactome database...
August 26, 2023: Journal of Ovarian Research
https://read.qxmd.com/read/37560861/rbc-transfusion-strategy-in-oncological-patients-with-chronic-rbc-transfusion-therapy
#25
JOURNAL ARTICLE
Weiwei Fang, Cheng Pang, Fanguo Zhang, Haipo Zhang, Tao Peng, Min Liu, Jingjing Yu, Ruijuan Zhao, Juan Cai, Simeng Chen, Xiying Li
BACKGROUND: Red blood cell (RBC) transfusion therapy has greatly reduced mortality and morbidity in multiply transfused patients with oncological malignancies. The aim of this study was to underline the necessity of introducing a policy for extended RBC phenotyping of these patients and for the issuing of antigen-matched blood (at least for E antigen). METHODS: Multivariate logistic regression analysis was used to evaluate the associations of age, gender, transfusion history, and various malignancies with the development of red cell alloimmunization...
August 1, 2023: Clinical Laboratory
https://read.qxmd.com/read/37550644/the-crucial-value-of-serum-ferritin-in-assessing-high-risk-factors-and-prognosis-for-patients-with-endometrial-carcinoma
#26
JOURNAL ARTICLE
Jiali Liu, Beibei Xuan, Quan Quan, Sainan Gong, Xiaoling Mu
BACKGROUND: Endometrial carcinoma is a common malignant tumor in female reproductive system. At present, there is no effective and economic prognostic index. This study aimed to investigate the effect of serum ferritin levels on the prognosis of endometrial carcinoma. METHODS: Data of 367 patients who diagnosed with endometrial carcinoma at the First Affiliated Hospital of Chongqing Medical University between January 2012 and August 2018 was retrospectively analyzed...
August 7, 2023: BMC Women's Health
https://read.qxmd.com/read/37497824/reduced-2-4-dienoyl-coa-reductase-1-is-served-as-an-unfavorable-biomarker-and-is-related-to-immune-infiltration-in-cervical-cancer
#27
JOURNAL ARTICLE
Suiqun Guo, Huiping Jiang, Yuanrun Deng, Yanqi Dong, Aiqi Yin, Qinghai Wang, Qiudai Lan, Yilin Zhang, Caiqiu Xu
BACKGROUND: Worldwide, cervical cancer (CC) remains the most prevalent malignancy of the female reproductive system, posing a threat to women's life and health, and increasing the medical and economic burden on society. Therefore, the search for tumor biomarkers for CC remains an important research direction. Immunotherapy has significantly improved patient outcomes, and genes related to tumor immune infiltration have been clinically relevant and highly reproducible biomarkers that affect the prognosis and response to treatment of CC...
July 27, 2023: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/37469398/ascites-derived-cdcp1-extracellular-vesicles-subcluster-as-a-novel-biomarker-and-therapeutic-target-for-ovarian-cancer
#28
JOURNAL ARTICLE
Lingnan Kong, Famei Xu, Yukuan Yao, Zhihui Gao, Peng Tian, Shichao Zhuang, Di Wu, Tangyue Li, Yanling Cai, Jing Li
INTRODUCTION: Ovarian cancer (OVCA) is one of the most prevalent malignant tumors of the female reproductive system, and its diagnosis is typically accompanied by the production of ascites. Although liquid biopsy has been widely implemented recently, the diagnosis or prognosis of OVCA based on liquid biopsy remains the primary emphasis. METHODS: In this study, using proximity barcoding assay, a technique for analyzing the surface proteins on single extracellular vesicles (EVs)...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37442264/fbxo22-inhibits-proliferation-and-metastasis-of-cervical-cancer-cells-by-mediating-ubiquitination-dependent-degradation-of-gak
#29
JOURNAL ARTICLE
Shanfeng Li, Lei Shi, You Wang, Lanxia Zhang, Sufang Chu, Minle Li, Jin Bai, Weipei Zhu
Cervical cancer is one of the recognized malignant tumors of female reproductive system. At present, the research and development of biomarkers has attracted increasing attention, and the wide application of clinical cervical cancer screening strategies has significantly reduced its morbidity and mortality. A member of the F-box protein family, FBXO22, is involved in cell cycle, DNA damage repair and many other processes. Dysregulation of FBXO22 plays an important role in the occurrence and development of various tumors, including ovarian cancer, liver cancer and lung cancer...
July 11, 2023: Experimental Cell Research
https://read.qxmd.com/read/37425140/the-haunting-diagnosis-of-malignancy-in-women-with-treatable-reproductive-system-tuberculosis
#30
Alex Mremi, Jeremia J Pyuza, Patrick Amsi, Elichilia R Shao, Gilbert Nkya, Ummil Jaabir, Alice A Andongolile, Angela Pallagyo
This study reports a case of female genital tuberculosis in a 46-year-old woman who presented to emergency department with abdominal pain and progressive abdominal distension. The patient was initially thought to have ovarian cancer based on clinical diagnosis and elevated cancer antigen-125 (CA-125) levels. Intra-operatively, no obvious ovarian tumor was encountered instead; disseminated creamy white patches on the uterus and left adnexa were seen. About 4500-mL straw-colored ascitic fluid and disseminated creamy white patches were also found on the bowels and omentum giving an impression of carcinomatosis...
2023: SAGE Open Medical Case Reports
https://read.qxmd.com/read/37408092/circular-rna-differential-expression-profiles-and-bioinformatics-analysis-of-hsa_circrna_079422-in-human-endometrial-carcinoma
#31
JOURNAL ARTICLE
Yuwei Li, Ziling Yang, Mengyao Zeng, Ying Wang, Xin Chen, Shibo Li, Xiaotong Zhao, Yuhui Sun
The aim of our study was to explore circular RNA (circRNA) expression profiles associated with human endometrial carcinoma (EC) and to analyse the molecular mechanisms involved in cancer development and their potential clinical importance. Differential expression profiles were revealed by Arraystar human circRNA microarray analysis. The results of the circRNA microarray were confirmed by quantitative real-time PCR. Interactions between circRNAs and microRNAs (miRNAs) were predicted using Arraystar's miRNA target prediction software...
December 2023: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/37397523/niclosamide-na-overcomes-cisplatin-resistance-in-human-ovarian-cancer
#32
JOURNAL ARTICLE
Linjuan Huang, Jing Zhang, Youling Deng, Hao Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Yonghui Wang, Connie Chen, William Wagstaff, Rex C Haydon, Russell R Reid, Tong-Chuan He, Le Shen, Hue H Luu, Ling Zhao
Ovarian cancer (OC) is one of the most lethal malignancies of the female reproductive system. OC patients are usually diagnosed at advanced stages due to the lack of early diagnosis. The standard treatment for OC includes a combination of debulking surgery and platinum-taxane chemotherapy, while several targeted therapies have recently been approved for maintenance treatment. The vast majority of OC patients relapse with chemoresistant tumors after an initial response. Thus, there is an unmet clinical need to develop new therapeutic agents to overcome the chemoresistance of OC...
July 2023: Genes & Diseases
https://read.qxmd.com/read/37369687/snord6-promotes-cervical-cancer-progression-by-accelerating-e6-mediated-p53-degradation
#33
JOURNAL ARTICLE
Qianhui Li, Bumin Xie, Xi Chen, Bingfeng Lu, Shuo Chen, Xiujie Sheng, Yang Zhao
Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs widely distributed in eukaryotic nucleoli. In recent years, studies have revealed that snoRNAs can also participate in the occurrence and development of malignant tumors through different pathways. Cervical cancer is one of the most common malignant tumors of the female reproductive system, and the high-risk HPV virus infection is its main pathogenic mechanism. However, the outcomes in different patients with malignant tumors vary, indicating that other factors might affect the pathogenic process of cervical cancer...
June 27, 2023: Cell Death Discovery
https://read.qxmd.com/read/37355027/aptamer-based-carbohydrate-antigen-125-sensor-with-molybdenum-disulfide-functional-hybrid-materials
#34
JOURNAL ARTICLE
Chang Hu, Ziyue Qin, Jie Fu, Qiya Gao, Chong Chen, Cherie S Tan, Shuang Li
Epithelial ovarian cancer is a malignant tumor of the female reproductive system with insidious symptoms, aggressiveness, risk of metastasis, and high mortality. Carbohydrate antigen 125 (CA125), a standard biomarker for screening epithelial ovarian cancer, can be applied to track cancer progression and treatment response. Here, we constructed an aptamer-based electrochemical biosensor to achieve sensitive detection of CA125. Molybdenum disulfide (MoS2 ) was used as the stable layered substrate, combined with the irregular branched structure of gold nanoflowers (AuNFs) to provide the sensing interface with a large specific surface area by one-step electrodeposition AuNFs@MoS2 ...
June 22, 2023: Analytical Biochemistry
https://read.qxmd.com/read/37325054/piwi-interacting-rna-17458-is-oncogenic-and-a-potential-therapeutic-target-in-cervical-cancer
#35
JOURNAL ARTICLE
Lianqin Liu, Liu Li, Wufan Zu, Jiayu Jing, Guanjun Liu, Tingyi Sun, Qi Xie
Cervical cancer (CC) is one of the leading cancers among the female reproductive system. The piwi-interacting RNA (piRNA) function and biogenesis has been studied in various cancers, including CC. But the precise mechanism of piRNA in CC is still unknown. In our study, we found that piRNA-17458 was overexpressed in CC tissues and cells. piRNA-17458 mimic and inhibitor promoted and suppressed proliferation, migration and invasion ability of CC cells, respectively. We also demonstrated that piRNA-17458 mimic could contribute to tumor growth in mice xenograft models...
2023: Journal of Cancer
https://read.qxmd.com/read/37304283/the-overexpression-of-actin-related-protein-2-3-complex-subunit-1b-arpc1b-promotes-the-ovarian-cancer-progression-via-activation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#36
JOURNAL ARTICLE
Junning Huang, Haiqin Zhou, Caichun Tan, Shien Mo, Tingji Liu, Yan Kuang
INTRODUCTION: Ovarian cancer is one of the most fatal malignancies of the female reproductive system. The purpose of this study is to explore the mechanism of Actin Related Protein 2/3 Complex Subunit 1B(ARPC1B) in the progression of ovarian cancer. METHODS: The expressions and prognostic value of ARPC1B in ovarian cancer were identified using the GEPIA database and the Kaplan-Meier Plotter database. The expression of ARPC1B was manipulated to evaluate its impact on the malignant phenotypes of ovarian cancer...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37277821/tumor-metabolism-rewiring-in-epithelial-ovarian-cancer
#37
REVIEW
Ming Wang, Jingjing Zhang, Yumei Wu
The mortality rate of epithelial ovarian cancer (EOC) remains the first in malignant tumors of the female reproductive system. The characteristics of rapid proliferation, extensive implanted metastasis, and treatment resistance of cancer cells require an extensive metabolism rewiring during the progression of cancer development. EOC cells satisfy their rapid proliferation through the rewiring of perception, uptake, utilization, and regulation of glucose, lipids, and amino acids. Further, complete implanted metastasis by acquiring a superior advantage in microenvironment nutrients competing...
June 5, 2023: Journal of Ovarian Research
https://read.qxmd.com/read/37239926/covid-19-the-shift-of-homeostasis-into-oncopathology-or-chronic-fibrosis-in-terms-of-female-reproductive-system-involvement
#38
REVIEW
Elena Petersen, Daria Chudakova, Daiana Erdyneeva, Dulamsuren Zorigt, Evgeniya Shabalina, Denis Gudkov, Pavel Karalkin, Igor Reshetov, Ospan A Mynbaev
The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus remains a global public health concern due to the systemic nature of the infection and its long-term consequences, many of which remain to be elucidated. SARS-CoV-2 targets endothelial cells and blood vessels, altering the tissue microenvironment, its secretion, immune-cell subpopulations, the extracellular matrix, and the molecular composition and mechanical properties. The female reproductive system has high regenerative potential, but can accumulate damage, including due to SARS-CoV-2...
May 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37200931/analysis-of-risk-factors-for-negative-emotions-in-perioperative-period-of-ovarian-cancer-patients-and-their-impact-on-prognosis
#39
JOURNAL ARTICLE
Jing He, Yang Zhang
BACKGROUND: Ovarian cancer (OC), a common malignant tumor of the female reproductive system, has the highest mortality rate among gynecologic cancers. Female patients often experience negative emotions such as anxiety and depression due to sex hormone disorders, fear of cancer, and unfamiliarity with the hospital environment. This study aimed to elucidate the risk factors of negative emotions in the perioperative period of OC patients and their effect on prognosis to provide a reference basis for improving patients' prognosis...
April 28, 2023: Gland Surgery
https://read.qxmd.com/read/37176048/association-of-membranous-wnt-1-and-nuclear-mtor-with-endometrial-cancer-grade
#40
JOURNAL ARTICLE
Milosz Pietrus, Kazimierz Pitynski, Marcin Waligora, Katarzyna Milian-Ciesielska, Artur Ludwin, Maciej W Socha, Klaudia Skrzypek
Endometrial cancer remains a common cancer affecting the female reproductive system. There is still a need for more efficient ways of determining the degree of malignancy and optimizing treatment. WNT and mTOR are components of signaling pathways within tumor cells, and dysfunction of either protein is associated with the pathogenesis of neoplasms. Therefore, the aim of our study was to assess the impact of subcellular WNT-1 and mTOR levels on the clinical course of endometrial cancer. WNT-1 and mTOR levels in the plasma membrane, nucleus, and cytoplasm were evaluated using immunohistochemical staining in a group of 64 patients with endometrial cancer of grades 1-3 and FIGO stages I-IV...
May 6, 2023: International Journal of Molecular Sciences
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