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genetically modified foods

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https://www.readbyqxmd.com/read/28913806/endogenous-reference-genes-and-their-quantitative-real-time-pcr-assays-for-genetically-modified-bread-wheat-triticum-aestivum-l-detection
#1
Litao Yang, Sheng Quan, Dabing Zhang
Endogenous reference genes (ERG) and their derivate analytical methods are standard requirements for analysis of genetically modified organisms (GMOs). Development and validation of suitable ERGs is the primary step for establishing assays that monitoring the genetically modified (GM) contents in food/feed samples. Herein, we give a review of the ERGs currently used for GM wheat analysis, such as ACC1, PKABA1, ALMT1, and Waxy-D1, as well as their performances in GM wheat analysis. Also, we discussed one model for developing and validating one ideal RG for one plant species based on our previous research work...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28913797/agribusiness-perspectives-on-transgenic-wheat
#2
Bill Malcolm
Declining yields of the major human food crops, looming growth in global population and rise of populism, and ill-founded bans on agricultural and horticultural crops and foodstuffs which are genetically modified have potentially serious implications. It makes the chance less than otherwise would be the case that agribusiness value chains in the future will meet the growing demand around the world for more and different foods from more and wealthier people. In the agribusiness value chain, transgenic wheat, meeting a consumer "trigger need" also must meet the "experience" and "credence," risk-related criteria of well-informed consumers...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28913796/allergenicity-assessment-of-transgenic-wheat-lines-in-silico
#3
Ankita Mishra, Naveen Arora
Agriculture biotechnology is a promising tool for developing varieties with enhanced quality and quantity. Transgenic proteins expressed by genetically modified (GM) food crops improve crop characteristics like nutritional value, taste, and texture, and endow plants with resistance against fungus, pests, and insects. Despite such potential benefits, there are concerns regarding possible adverse effects of GM crops on human health, animals and the environment. Among the proposed guidelines for GM food safety testing-the weight-of-evidence approach proposed by the Codex Alimentarius Commission (ALINORM 03/34A) is the most recent...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28898466/an-overview-of-genetically-modified-crop-governance-issues-and-challenges-in-malaysia
#4
REVIEW
Andrew Johnny, Ismail Normaz Wana, Djama Marcel
The application of agricultural biotechnology attracts the interest of many stakeholders. Genetically modified (GM) crops, for example, are rapidly increase in production for the last 20 years. Despite its known benefits, GM crops also pose many concerns not only to human and animal health but also the environment. Malaysia, in general, allows the use of GM technology applications but it has to come with precautionary and safety measures consistent with the international obligations and domestic legal frameworks...
September 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28894443/improved-vaccine-against-prrsv-current-progress-and-future-perspective
#5
REVIEW
Yuchen Nan, Chunyan Wu, Guoqian Gu, Weiyao Sun, Yan-Jin Zhang, En-Min Zhou
Porcine reproductive and respiratory syndrome virus (PRRSV), one of the most economically significant pathogens worldwide, has caused numerous outbreaks during the past 30 years. PRRSV infection causes reproductive failure in sows and respiratory disease in growing and finishing pigs, leading to huge economic losses for the swine industry. This impact has become even more significant with the recent emergence of highly pathogenic PRRSV strains from China, further exacerbating global food security. Since new PRRSV variants are constantly emerging from outbreaks, current strategies for controlling PRRSV have been largely inadequate, even though our understanding of PRRSV virology, evolution and host immune response has been rapidly expanding...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28891383/a-hypothesis-moderate-consumption-of-alcoholic-beverages-contributes-to-lower-prevalence-of-type-2-diabetes-t2dm-due-to-scavenging-of-%C3%AE-dicarbonyls-by-several-classes-of-dietary-phytochemicals
#6
Benjamin S Szwergold
The world is experiencing an epidemic of Type-2-Diabetes (T2DM). This has led to increased morbidity and mortality, explosive growth in heath-care budgets and has an even greater, if indirect, impact on societies and economies of the affected countries. While genetic susceptibility to T2DM is a major determinant of its prevalence, changes in life-styles also play a role. One such change has been a transition from traditional diets characterized by low caloric and high nutrient density to calorie-rich but nutrient-poor Western diets...
September 11, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28890018/the-allergenicity-of-genetically-modified-foods-from-genetically-engineered-crops-a-narrative-and-systematic-review
#7
REVIEW
S Eliza Dunn, John L Vicini, Kevin C Glenn, David M Fleischer, Matthew J Greenhawt
No abstract text is available yet for this article.
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28890014/genetically-modified-products-and-food-allergy-beliefs-evidence-and-opportunity
#8
EDITORIAL
John Compton, Joseph B Fanning, Andrew S Nickels
No abstract text is available yet for this article.
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28889778/genotoxicity-testing-progress-and-prospects-for-the-next-decade
#9
Hasan Turkez, Mehmet E Arslan, Ozlem Ozdemir
Genotoxicity and mutagenicity analyses have a significant role in the identification of hazard effects of therapeutic drugs, cosmetics, agrochemicals, industrial compounds, food additives, natural toxins and nanomaterials for regulatory purposes. To evaluate mutagenicity or genotoxicity, different in vitro and in vivo methodologies exert various genotoxicological endpoints such as point mutations, changes in number and structure of chromosomes. Areas covered: This review covered the basics of genotoxicity and in vitro/in vivo methods for determining of genetic damages...
September 10, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28884629/maternal-lifestyle-impairs-embryonic-growth-the-rotterdam-periconception-cohort
#10
Matthijs R Van Dijk, Nicole V Borggreven, Sten P Willemsen, Anton H J Koning, Régine P M Steegers-Theunissen, Maria P H Koster
Previously, embryonic growth has been assumed to be uniform, but in recent years, it has become more clear that genetic and environmental factors may influence the intrauterine environment and therefore embryonic growth trajectories as well as pregnancy course and outcome. The objective of this study was to investigate associations between modifiable maternal nutrition and lifestyle factors during the periconception period and embryonic growth. We established a prospective cohort including 342 women less than 13 weeks pregnant...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28878216/environmental-stress-is-the-major-cause-of-transcriptomic-and-proteomic-changes-in-gm-and-non-gm-plants
#11
Rita Batista, Cátia Fonseca, Sébastien Planchon, Sónia Negrão, Jenny Renaut, M Margarida Oliveira
The approval of genetically modified (GM) crops is preceded by years of intensive research to demonstrate safety to humans and environment. We recently showed that in vitro culture stress is the major factor influencing proteomic differences of GM vs. non-GM plants. This made us question the number of generations needed to erase such "memory". We also wondered about the relevance of alterations promoted by transgenesis as compared to environment-induced ones. Here we followed three rice lines (1-control, 1-transgenic and 1-negative segregant) throughout eight generations after transgenesis combining proteomics and transcriptomics, and further analyzed their response to salinity stress on the F6 generation...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28831923/the-food-and-drug-addiction-epidemic-targeting-dopamine-homeostasis
#12
Kenneth Blum, Panayotis K Thanos, Gene-Jack Wang, Marcelo Febo, Zsolt Demetrovics, Edward Justin Modestino, Eric R Braverman, David Baron, Rajendra D Badgaiyan, Mark S Gold
Obesity is damaging the lives of more than 300 million people worldwide and maintaining a healthy weight using popular weight loss tactics remains a very difficult undertaking. Managing the obesity problem seems within reach, as better understanding develops, of the function of our genome in drug/nutrient responses. Strategies indicated by this understanding of nutriepigenomics and neurogenetics in the treatment and prevention of metabolic syndrome and obesity include moderation of mRNA expression by DNA methylation, and inhibition of histone deacetylation...
August 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28830835/bioinformatics-analysis-to-assess-potential-risks-of-allergenicity-and-toxicity-of-hrap-and-pflp-proteins-in-genetically-modified-bananas-resistant-to-xanthomonas-wilt-disease
#13
Yuan Jin, Richard E Goodman, Afua O Tetteh, Mei Lu, Leena Tripathi
Banana Xanthomonas wilt (BXW) disease threatens banana production and food security throughout East Africa. Natural resistance is lacking among common cultivars. Genetically modified (GM) bananas resistant to BXW disease were developed by inserting the hypersensitive response-assisting protein (Hrap) or/and the plant ferredoxin-like protein (Pflp) gene(s) from sweet pepper (Capsicum annuum). Several of these GM banana events showed 100% resistance to BXW disease under field conditions in Uganda. The current study evaluated the potential allergenicity and toxicity of the expressed proteins HRAP and PFLP based on evaluation of published information on the history of safe use of the natural source of the proteins as well as established bioinformatics sequence comparison methods to known allergens (www...
August 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28827344/individuals-with-greater-science-literacy-and-education-have-more-polarized-beliefs-on-controversial-science-topics
#14
Caitlin Drummond, Baruch Fischhoff
Although Americans generally hold science in high regard and respect its findings, for some contested issues, such as the existence of anthropogenic climate change, public opinion is polarized along religious and political lines. We ask whether individuals with more general education and greater science knowledge, measured in terms of science education and science literacy, display more (or less) polarized beliefs on several such issues. We report secondary analyses of a nationally representative dataset (the General Social Survey), examining the predictors of beliefs regarding six potentially controversial issues...
August 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28819142/development-and-inter-laboratory-assessment-of-droplet-digital-pcr-assays-for-multiplex-quantification-of-15-genetically-modified-soybean-lines
#15
Alexandra Bogožalec Košir, Bjørn Spilsberg, Arne Holst-Jensen, Jana Žel, David Dobnik
Quantification of genetically modified organisms (GMOs) in food and feed products is often required for their labelling or for tolerance thresholds. Standard-curve-based simplex quantitative polymerase chain reaction (qPCR) is the prevailing technology, which is often combined with screening analysis. With the rapidly growing number of GMOs on the world market, qPCR analysis becomes laborious and expensive. Innovative cost-effective approaches are therefore urgently needed. Here, we report the development and inter-laboratory assessment of multiplex assays to quantify GMO soybean using droplet digital PCR (ddPCR)...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28809975/discovery-of-synthetic-small-molecules-that-enhance-the-number-of-stomata-c-h-functionalization-chemistry-for-plant-biology
#16
Asraa Ziadi, Naoyuki Uchida, Hiroe Kato, Rina Hisamatsu, Ayato Sato, Shinya Hagihara, Kenichiro Itami, Keiko U Torii
The increasing climate changes and global warming are leading to colossal agricultural problems such as abatement of food production and quality. As stomatal development is considered to play a key role in crop plant productivity and water-use efficiency, studying stomatal development is useful for understanding the productivity of plant systems for both natural and agricultural systems. Herein, we report the first-in-class synthetic small molecules enhancing the number of stomata in Arabidopsis thaliana that have been discovered by screening of the chemical library and further optimized by the Pd-catalyzed C-H arylation reaction...
August 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28799326/glucagon-like-peptide-1-conjugated-to-recombinant-human-serum-albumin-variants-with-modified-neonatal-fc-receptor-binding-properties-impact-on-molecular-structure-and-half-life
#17
Jens T Bukrinski, Pernille Sønderby, Filipa Antunes, Birgitte Andersen, Esben G W Schmidt, Günther H J Peters, Pernille Harris
Glucagon-like peptide 1 (GLP-1) is a small incretin hormone stimulated by food intake, resulting in an amplification of the insulin response. Though GLP-1 is interesting as a drug candidate for the treatment of type 2 diabetes mellitus, its short plasma half-life of <3 min limits its clinical use. A strategy for extending the half-life of GLP-1 utilizes the long half-life of human serum albumin (HSA) by combining the two via chemical conjugation or genetic fusion. HSA has a plasma half-life of around 21 days because of its interaction with the neonatal Fc receptor (FcRn) expressed in endothelial cells of blood vessels, which rescues circulating HSA from lysosomal degradation...
August 25, 2017: Biochemistry
https://www.readbyqxmd.com/read/28795123/corrigendum-to-data-in-support-of-the-detection-of-genetically-modified-organisms-gmos-in-food-and-feed-samples-data-brief-7-2016-pp-243-252
#18
(no author information available yet)
[This corrects the article DOI: 10.1016/j.dib.2016.02.035.].
September 2016: Data in Brief
https://www.readbyqxmd.com/read/28792800/national-antimicrobial-resistance-monitoring-system-two-decades-of-advancing-public-health-through-integrated-surveillance-of-antimicrobial-resistance
#19
Beth E Karp, Heather Tate, Jodie R Plumblee, Uday Dessai, Jean M Whichard, Eileen L Thacker, Kis Robertson Hale, Wanda Wilson, Cindy R Friedman, Patricia M Griffin, Patrick F McDermott
Drug-resistant bacterial infections pose a serious and growing public health threat globally. In this review, we describe the role of the National Antimicrobial Resistance Monitoring System (NARMS) in providing data that help address the resistance problem and show how such a program can have broad positive impacts on public health. NARMS was formed two decades ago to help assess the consequences to human health arising from the use of antimicrobial drugs in food animal production in the United States. A collaboration among the Centers for Disease Control and Prevention, the U...
August 9, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28770337/overexpression-of-biologically-safe-rorippa-indica-defensin-enhances-aphid-tolerance-in-brassica-juncea
#20
Poulami Sarkar, Kuladip Jana, Samir Ranjan Sikdar
Transgenic mustard plants ( Brassica juncea ) expressing non-allergenic and biologically safe RiD peptide show higher tolerance against Lipaphis erysimi. Rorippa indica defensin (RiD) has previously been reported as a novel insecticidal protein derived from a wild crucifer Rorippa indica. RiD was found to have an effective insecticidal property against mustard aphid, Lipaphis erysimi. In the present study, RiD was highly upregulated in R. indica during aphid infestation initiating a defense system mediated by jasmonic acid (JA), but not by salicylic acid (SA)/abscisic acid (ABA)...
August 2, 2017: Planta
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