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https://www.readbyqxmd.com/read/28207510/endovascular-repair-of-bilateral-common-iliac-artery-aneurysms-using-gore-excluder-iliac-branch-endoprosthesis-without-aortobi-iliac-stent-graft-conjunction-a-case-report
#1
Vincenzo Ardita, Alessia Giaquinta, Massimiliano Veroux, Angelo Sanfiorenzo, Carla Virgilio, Giuseppe D'Arrigo, Pierfrancesco Veroux
INTRODUCTION: Bilateral common iliac artery (CIA) aneurysm (CIAA) is a rare entity. In the past decade, different endovascular approaches have been adopted for patients with several comorbidities or unfit for open repair (OR). Recently, the use of iliac branch stent graft has been proposed, resulting in satisfactory patency rates and decrease in morbidity. Currently, according to instruction for use, the iliac branch stent graft is to be used with aortobi-iliac stent graft conjunction...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28192100/disease-modifying-anti-rheumatic-activity-of-the-alkaloid-montanine-on-experimental-arthritis-and-fibroblast-like-synoviocytes
#2
Mirian Farinon, Vanessa S Clarimundo, Graziele P R Pedrazza, Pércio S Gulko, José A S Zuanazzi, Ricardo M Xavier, Patricia G de Oliveira
Montanine is an alkaloid isolated from Rhodophiala bifida bulb with potential anti-arthritic activity. In this context, we evaluated wether montanine has a disease modifying anti-rheumatic activity in two arthritis models and its effect in vitro on lymphocyte proliferation and on invasiveness of fibroblast-like synoviocytes (FLS). Antigen-induced arthritis (AIA) was performed in Balb/C mice with methylated bovine serum albumin, and nociception and leukocytes migration into the knee joint were evaluated. Collagen-induced arthritis (CIA) was performed in DBA/1J mice, and arthritis development and severity were assessed by clinical and histological scoring and articular nociception...
February 10, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28191643/cd11b-regulates-via-il-6-the-treg-th17-balance-in-murine-arthritis
#3
Mathias Stevanin, Nathalie Busso, Veronique Chobaz, Matteo Pigni, Sahar Ghassem-Zadeh, Li Zhang, Hans Acha-Orbea, Driss Ehirchiou
Th17 cells are often associated with autoimmunity and been shown to be increased in CD11b(-/-) mice. Here, we examined the role of CD11b in murine collagen-induced arthritis (CIA)-induced arthritis. C57BL/6 and CD11b(-/-) resistant mice were immunized with type II collagen. CD11b(-/-) mice developed arthritis with early onset, high incidence and sustained severity compared with C57BL/6 mice. We observed a marked leukocyte infiltration, and histological examinations of the arthritic paws from CD11b(-/-) mice revealed that the cartilage was destroyed in association with strong lymphocytic infiltration...
February 12, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28188486/validation-of-a-method-for-retroperitoneal-tumor-segmentation
#4
Cristina Suárez-Mejías, José A Pérez-Carrasco, Carmen Serrano, José L López-Guerra, Tomás Gómez-Cía, Carlos L Parra-Calderón, Begoña Acha
PURPOSE: In 2005, an application for surgical planning called AYRA[Formula: see text] was designed and validated by different surgeons and engineers at the Virgen del Rocío University Hospital, Seville (Spain). However, the segmentation methods included in AYRA and in other surgical planning applications are not able to segment accurately tumors that appear in soft tissue. The aims of this paper are to offer an exhaustive validation of an accurate semiautomatic segmentation tool to delimitate retroperitoneal tumors from CT images and to aid physicians in planning both radiotherapy doses and surgery...
February 10, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28188247/neurodegeneration-enhances-the-development-of-arthritis
#5
Stefanie C Lang, Ulrike Harre, Pavitra Purohit, Katharina Dietel, Deborah Kienhöfer, Jonas Hahn, Wolfgang Baum, Martin Herrmann, Georg Schett, Dirk Mielenz
The prevalence of neurodegenerative disease and arthritis increases with age. Despite both processes being associated with immune activation and inflammation, little is known about the mechanistic interactions between neurodegenerative disease and arthritis. In this article, we show that tau-transgenic (tau-tg) mice that develop neurodegenerative disease characterized by deposition of tau tangles in the brain are highly susceptible to developing arthritis. Already at steady-state conditions, tau-tg mice exhibit peripheral immune activation that is manifested by higher numbers of granulocytes, plasmablasts, and inflammatory Ly6C(hi) CCR2(+) monocytes, as well as increased levels of proinflammatory cytokines, such as TNF-α and IL-17...
February 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28179174/sedation-during-surgery-for-movement-disorders-and-perioperative-neurological-complications-an-observational-study-comparing-local-anesthesia-remifentanil-and-dexmedetomidine
#6
Maria Cristina Honorato-Cia, Antonio Martinez-Simón, Jorge Guridi, Manuel Alegre, Jorge Nuñes-Cordoba
No abstract text is available yet for this article.
February 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28178521/the-cia-targeting-complex-is-highly-regulated-and-provides-two-distinct-binding-sites-for-client-iron-sulfur-proteins
#7
Diana C Odermatt, Kerstin Gari
The cytoplasmic iron-sulfur assembly (CIA) targeting complex is required for the transfer of an iron-sulfur (Fe-S) cluster to cytoplasmic and nuclear proteins, but how it engages with client proteins is unknown. Here, we show that the complex members MIP18 and CIAO1 associate with the C terminus of MMS19. By doing so, they form a docking site for Fe-S proteins that is disrupted in the absence of either MMS19 or MIP18. The Fe-S helicase XPD seems to be the only exception, since it can interact with MMS19 independently of MIP18 and CIAO1...
February 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/28165872/nampt-is-an-essential-regulator-of-ra-mediated-periodontal-inflammation
#8
D Kim, G Lee, Y H Huh, S Y Lee, K H Park, S Kim, J Kim, J Koh, J Ryu
Recent studies have indicated a potential correlation between rheumatoid arthritis (RA) and periodontal inflammation. We undertook this study to verify whether RA mediates periodontitis-like phenotypes in experimental mouse models of RA and to explore the role of nicotinamide phosphoribosyltransferase (NAMPT) in periodontal inflammation during RA pathogenesis. Periodontal inflammation and alveolar bone loss have been reported in mice with collagen-induced arthritis (CIA) and in genetically modified tumor necrosis factor-α (TNF-α) transgenic (TG) mouse models...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28163269/successful-endovascular-treatment-of-aortoiliac-bifurcation-stenosis-using-an-empirically-based-t-and-protrude-stenting-with-self-and-balloon-expandable-stents
#9
Ken-Ichiro Sasaki, Hidetoshi Chibana, Takafumi Ueno, Naoki Itaya, Masahiro Sasaki, Yoshihiro Fukumoto
A 73-year-old woman with arteriosclerosis obliterans (ASO) was underwent a crossover stenting for an aortoiliac bifurcation from the right common iliac artery (CIA) with a self-expandable bare-metal stent (SE-BMS); however, a new stenosis later occurred just behind the bifurcation of the left CIA. An ex vivo experiment demonstrated that culotte-stenting by additional implantation of a balloon-expandable bare-metal stent (BE-BMS) through stent struts of the SE-BMS would be empirically infeasible. Although we had initially planned a T-stenting for the additional implantation of a BE-BMS in the left CIA, we finally deployed the stent in the CIA with the proximal end protruding into the previously-implanted SE-BMS through the stent struts to avoid incomplete coverage of the stenosis by reference to the ex vivo experiments...
February 6, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/28163195/positive-selection-of-type-ii-collagen-reactive-cd80-high-marginal-zone-b-cells-in-dba-1-mice
#10
Chanho Park, In Seong Kho, Jeong In Yang, Min-Jung Kim, Sunhoo Park, Hoon-Suk Cha, Jaejoon Lee, Tae Jin Kim
To investigate whether dysregulated selection of autoreactive marginal zone (MZ) B cells is involved in autoimmune diseases, we examined MZ B cell profile in multiple strains of mice, and found that type II collagen (CII)-reactive autoreactive CD80(high) MZ B cells spontaneously developed in the DBA/1, but not in C57BL/6 mice. CD80(high) MZ B cells that were characteristically found in DBA/1 mice expressed higher levels of TACI, SLAM3, and SLAM6 than the usual CD80(low) MZ B cells. Notably, the CD80(high) MZ B cells were more sensitive to ibrutinib, a Bruton's tyrosine kinase inhibitor, than CD80(low) MZ or follicular B cells and their transient depletion via intravenous injection of ibrutinib significantly delayed the induction of collagen-induced arthritis (CIA)...
February 2, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28159294/protease-inhibitors-in-various-flours-and-breads-effect-of-fermentation-baking-and-in-vitro-digestion-on-trypsin-and-chymotrypsin-inhibitory-activities
#11
Mine Kostekli, Sibel Karakaya
In this study trypsin (TIA) and chymotrypsin inhibitory (CIA) activities were determined in the extracts of wheat, rye mix, mixed cereals and, whole wheat flours and, breads made with these flours. In addition, effects of fermentation, baking and in vitro digestion on TIA and CIA were studied. Whole wheat flour, dough, and bread did not show any TIA. Other flours displayed TIA. Contrary to, all flours, doughs, and breads exhibited CIA. Although TIA was not detected in the protein extracts obtained from wheat and rye mix breads, protein extract of rye mix flour exhibited TIA...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28158305/higher-efficacy-of-anti-il-6-il-21-combination-therapy-compared-to-monotherapy-in-the-induction-phase-of-th17-driven-experimental-arthritis
#12
Debbie M Roeleveld, Renoud J Marijnissen, Birgitte Walgreen, Monique M Helsen, Liduine van den Bersselaar, Fons A van de Loo, Peter L van Lent, Peter M van der Kraan, Wim B van den Berg, Marije I Koenders
Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation. Th17 development is initiated by combined signaling of TGF-β and IL-6 or IL-21, and can be reduced in the absence of either IL-6 or IL-21. The aim of this study was to assess whether combinatorial IL-6/IL-21 blockade would more potently inhibit Th17 development, and be more efficacious in treating arthritis than targeting either cytokine. We assessed in vitro Th17 differentiation efficacy in the absence of IL-6 and/or IL-21...
2017: PloS One
https://www.readbyqxmd.com/read/28158203/silymarin-suppresses-basal-and-stimulus-induced-activation-exhaustion-differentiation-and-inflammatory-markers-in-primary-human-immune-cells
#13
Erica S Lovelace, Nicholas J Maurice, Hannah W Miller, Chloe K Slichter, Robert Harrington, Amalia Magaret, Martin Prlic, Stephen De Rosa, Stephen J Polyak
Silymarin (SM), and its flavonolignan components, alter cellular metabolism and inhibit inflammatory status in human liver and T cell lines. In this study, we hypothesized that SM suppresses both acute and chronic immune activation (CIA), including in the context of HIV infection. SM treatment suppressed the expression of T cell activation and exhaustion markers on CD4+ and CD8+ T cells from chronically-infected, HIV-positive subjects. SM also showed a trend towards modifying CD4+ T cell memory subsets from HIV+ subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28154297/outcomes-of-endovascular-repair-of-aortoiliac-aneurysms-and-analyses-of-anatomic-suitability-for-internal-iliac-artery-preserving-devices-in-japanese-patients
#14
Nathan K Itoga, Naoki Fujimura, Keita Hayashi, Hideaki Obara, Hideyuki Shimizu, Jason T Lee
BACKGROUND: Understanding that the common iliac arteries (CIA) are shorter in Asian patients, we investigated whether this anatomic difference affects the clinical outcomes of internal iliac artery (IIA) exclusion during endovascular aneurysm repair (EVAR) of aortoiliac aneurysm and thus limits the use of IIA-preserving devices in Japanese patients.Methods and Results:From 2008 to 2014, 69 Japanese patients underwent EVAR of aortoiliac aneurysms with 53 unilateral and 16 bilateral IIA exclusions...
February 2, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28150447/chemotherapy-induced-alopecia-management-clinical-experience-and-practical-advice
#15
Alfredo Rossi, Maria Caterina Fortuna, Gemma Caro, Giulia Pranteda, Valentina Garelli, Umberto Pompili, Marta Carlesimo
BACKGROUND: Chemotherapy-induced alopecia (CIA) is probably one of the most shocking aspects for oncological patients and underestimated by physicians. Among hair loss risk factors, there are treatment-related aspects such as drug dose, administration regimen, and exposure to X-rays, but also patient-related characteristics. To the best of our knowledge, no guidelines are available about CIA management. AIMS AND METHODS: With this study, based on literature background and our clinical experience, we would like to propose a list of actions in order to estimate the risk of hair loss before starting chemotherapy and to manage this condition before, during, and after drug administration and to create a sort of practical guide for dermatologists and oncologists...
February 2, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28132121/assessment-of-caregiver-inventory-for-rett-syndrome
#16
Jane B Lane, Amber R Salter, Nancy E Jones, Gary Cutter, Joseph Horrigan, Steve A Skinner, Walter E Kaufmann, Daniel G Glaze, Jeffrey L Neul, Alan K Percy
Rett syndrome (RTT) requires total caregiver attention and leads to potential difficulties throughout life. The Caregiver Burden Inventory, designed for Alzheimer disease, was modified to a RTT Caregiver Inventory Assessment (RTT CIA). Reliability and face, construct, and concurrent validity were assessed in caregivers of individuals with RTT. Chi square or Fisher's exact test for categorical variables and t tests or Wilcoxon two-sample tests for continuous variables were utilized. Survey completed by 198 caregivers; 70 caregivers completed follow-up assessment...
January 28, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28127805/antiinflammation-effects-and-mechanisms-study-of-geniposide-on-rats-with-collagen-induced-arthritis
#17
Rong Wang, Hong Wu, Jian Chen, Shu-Ping Li, Li Dai, Zheng-Rong Zhang, Wen-Yu Wang
Geniposide (GE), an iridoid glycoside compound purified from Gardenia jasminoides Ellis, has antiinflammatory and other pharmacological effects, but its mechanism of actions on rheumatoid arthritis (RA) have not been clarified. The purpose of this article was to investigate the pharmacological effects of GE on collagen-induced arthritis (CIA) rats and its feasible mechanisms. Collagen-induced arthritis was induced by injection of chicken type II collagen emulsion. The rats were orally administered with GE (33, 66, and 132 mg/kg) from days 14 to 30 after immunization...
January 27, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28124096/defective-germinal-center-b-cell-response-and-reduced-arthritic-pathology-in-microrna-29a-deficient-mice
#18
Annemarie van Nieuwenhuijze, James Dooley, Stéphanie Humblet-Baron, Jayasree Sreenivasan, Marije Koenders, Susan M Schlenner, Michelle Linterman, Adrian Liston
MicroRNA (miR) are short non-coding RNA sequences of 19-24 nucleotides that regulate gene expression by binding to mRNA target sequences. The miR-29 family of miR (miR-29a, b-1, b-2 and c) is a key player in T-cell differentiation and effector function, with deficiency causing thymic involution and a more inflammatory T-cell profile. However, the relative roles of different miR-29 family members in these processes have not been dissected. We studied the immunological role of the individual members of the miR-29 family using mice deficient for miR-29a/b-1 or miR-29b-2/c in homeostasis and during collagen-induced arthritis...
January 25, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28123483/protective-effects-of-fructus-sophorae-extract-on-collagen-induced-arthritis-in-balb-c-mice
#19
Hyoung-Min Han, Su-Hyun Hong, Heung-Sik Park, Jae-Chul Jung, Jong-Sik Kim, Yong-Tae Lee, Eun-Woo Lee, Yung-Hyun Choi, Byung-Woo Kim, Cheol-Min Kim, Kyung-Hwa Kang
Styphnolobium japonicum (L.) is utilized in Korean medicine for the treatment of various inflammatory diseases. The aim of the present study was to explore the effects of Fructus sophorae extract (FSE) isolated from the dried ripe fruit of S. japonicum (L.) on the development of type II collagen-induced arthritis (CIA) in BALB/c mice. The CIA mice were orally administered FSE or saline daily for 2 weeks. The incidence and severity of disease and the inflammatory response in the serum and the joint tissues were assessed...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123248/rate-of-intrusion-of-maxillary-incisors-in-class-ii-div-1-malocclusion-using-skeletal-anchorage-device-and-connecticut-intrusion-arch
#20
Prasanna Kumar, Sanjeev Datana, S M Londhe, Abhijeet Kadu
BACKGROUND: Nonsurgical correction of deep bite involves either extrusion of posterior teeth, intrusion of incisors, or combination of both. The introduction of skeletal anchorage device with microimplant provides near absolute anchorage without producing any untoward effects on anchor unit. Connecticut Intrusion Arch (CIA) provided an efficient system of intruding anterior segment without producing much adverse affects on anchor teeth. METHODS: The study comprised of 30 patients of Class II Div 1 malocclusion with overbite of >6 mm and required therapeutic extractions of all first premolars, randomly distributed into two groups...
January 2017: Medical Journal, Armed Forces India
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