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https://www.readbyqxmd.com/read/29225034/cytosolic-iron-sulfur-assembly-is-evolutionarily-tuned-by-a-cancer-amplified-ubiquitin-ligase
#1
Jenny L Weon, Seung Wook Yang, Patrick Ryan Potts
The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway functions to incorporate inorganic Fe-S cofactors into a variety of proteins, including several DNA repair enzymes. However, the mechanisms regulating the CIA pathway are unknown. We describe here that the MAGE-F1-NSE1 E3 ubiquitin ligase regulates the CIA pathway through ubiquitination and degradation of the CIA-targeting protein MMS19. Overexpression or knockout of MAGE-F1 altered Fe-S incorporation into MMS19-dependent DNA repair enzymes, DNA repair capacity, sensitivity to DNA-damaging agents, and iron homeostasis...
November 30, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29223140/collagen-induced-arthritis-analysis-in-rhbdf2-knockout-mouse
#2
Min-Young Lee, Ju-Seong Kang, Ryeo-Eun Go, Yong-Sub Byun, Young Jin Wi, Kyung-A Hwang, Jae-Hoon Choi, Hyoung-Chin Kim, Kyung-Chul Choi, Ki-Hoan Nam
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α) converting enzyme, which is the molecule responsible for the release of TNF-α. In this study, Rhbdf2 knockout (KO) mice were produced by CRISPR/CAS9. To see the effects of the failure of TNF-α release induced by Rhbdf2 gene KO, collagen-induced arthritis (CIA), which is the representative TNF-α related disease, was induced in the Rhbdf2 mutant mouse using chicken collagen type II...
December 8, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29219157/protein-networks-in-the-maturation-of-human-iron-sulfur-proteins
#3
REVIEW
Simone Ciofi-Baffoni, Veronica Nasta, Lucia Banci
The biogenesis of iron-sulfur (Fe-S) proteins in humans is a multistage process occurring in different cellular compartments. The mitochondrial iron-sulfur cluster (ISC) assembly machinery composed of at least 17 proteins assembles mitochondrial Fe-S proteins. A cytosolic iron-sulfur assembly (CIA) machinery composed of at least 13 proteins has been more recently identified and shown to be responsible for the Fe-S cluster incorporation into cytosolic and nuclear Fe-S proteins. Cytosolic and nuclear Fe-S protein maturation requires not only the CIA machinery, but also the components of the mitochondrial ISC assembly machinery...
December 8, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29201902/in-vivo-studies-on-the-influence-of-bacteriophage-preparations-on-the-autoimmune-inflammatory-process
#4
Ryszard Międzybrodzki, Jan Borysowski, Marlena Kłak, Ewa Jończyk-Matysiak, Bożena Obmińska-Mrukowicz, Agnieszka Suszko-Pawłowska, Barbara Bubak, Beata Weber-Dąbrowska, Andrzej Górski
Phage preparations used for phage therapy may have not only direct antibacterial action but also immunomodulating effects mediated by phages themselves as well as by bacterial antigens. Therefore phage application in patients with immune disorders, and especially with autoimmune diseases, requires special attention. The aim of this study was to investigate the effect of phage lysates (staphylococcal phages A3/R, phi200, and MS-1 cocktail, enterococcal phage 15/P, Pseudomonas phage 119x, and E. coli T4 phage) as well as purified T4 phage on the course of murine collagen-induced arthritis (CIA), commonly used as an animal model of rheumatoid arthritis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29196861/crispr-based-strategies-for-studying-regulatory-elements-and-chromatin-structure-in-mammalian-gene-control
#5
REVIEW
Cia-Hin Lau, Yousin Suh
The development of high-throughput methods has enabled the genome-wide identification of putative regulatory elements in a wide variety of mammalian cells at an unprecedented resolution. Extensive genomic studies have revealed the important role of regulatory elements and genetic variation therein in disease formation and risk. In most cases, there is only correlative evidence for the roles of these elements and non-coding changes within these elements in pathogenesis. With the advent of genome- and epigenome-editing tools based on the CRISPR technology, it is now possible to test the functional relevance of the regulatory elements and alterations on a genomic scale...
December 1, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29190705/arthritic-role-of-porphyromonas-gingivalis-in-collagen-induced-arthritis-mice
#6
Hyerin Jung, Seung Min Jung, Yeri Alice Rim, Narae Park, Yoojun Nam, Jennifer Lee, Sung-Hwan Park, Ji Hyeon Ju
Epidemiological studies show an association between rheumatoid arthritis (RA) and periodontal disease. Porphyromonas gingivalis (P.gingivalis) is a well-known pathogen in periodontitis. This study investigated the pathogenic effects of P.gingivalis on autoimmune arthritis in vivo. Collagen-induced arthritis (CIA) mice were intraperitoneally injected with W83 and 2561 strains of P.gingivalis. Infection with P.gingivalis exacerbated arthritis score in CIA mice. Synovial inflammation and bone destruction in CIA mice infected with P...
2017: PloS One
https://www.readbyqxmd.com/read/29187339/sophocarpine-suppress-inflammatory-response-in-human-fibroblast-like-synoviocytes%C3%A2-and-in-mice-with-collagen-induced-arthritis
#7
Lihua Zhu, Liyan Zhu
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting nearly 1% of adults worldwide. This study aimed to investigate whether sophocarpine is a potential drug for treating RA. The cytotoxicity of sophocarpine to RA-fibroblast-like synoviocytes (FLSs) was evaluated using 3-[4,-dimethylthiazol-2-y]-2,5-diphenyl-tetrazolium bromide (MTT) assays kit and released lactate dehydrogenase (LDH) assays. The transcription of proinflammatory cytokines in RA-FLSs was analyzed by reverse transcription and real-time polymerase chain reaction (RT-PCR)...
September 1, 2017: European Cytokine Network
https://www.readbyqxmd.com/read/29184764/dual-energy-ct-angiography-in-peripheral-arterial-stents-optimal-scanning-protocols-with-regard-to-image-quality-and-radiation-dose
#8
Abdulrahman Almutairi, Zakariya Al Safran, Saif A AlZaabi, Zhonghua Sun
Background: To determine the optimal scanning protocols of dual energy computed tomography angiography (DECTA) in terms of radiation dose and image quality assessment at different keV levels, and compare it with conventional computed tomography angiography (CTA) in patients treated with peripheral arterial stents. Methods: Twenty-nine patients with previous stent placement in peripheral arteries were evaluated with DECTA. Images were reconstructed with virtual monochromatic spectral imaging (VMS) at 65, 68, 70 and 72 keV and adaptive statistical iterative reconstruction (ASIR) at 50% compared with CTA...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29184498/development-of-the-digital-arthritis-index-a-novel-metric-to-measure-disease-parameters-in-a-rat-model-of-rheumatoid-arthritis
#9
Maria A Lim, Brenton Louie, Daniel Ford, Kyle Heath, Paulyn Cha, Joe Betts-Lacroix, Pek Yee Lum, Timothy L Robertson, Laura Schaevitz
Despite a broad spectrum of anti-arthritic drugs currently on the market, there is a constant demand to develop improved therapeutic agents. Efficient compound screening and rapid evaluation of treatment efficacy in animal models of rheumatoid arthritis (RA) can accelerate the development of clinical candidates. Compound screening by evaluation of disease phenotypes in animal models facilitates preclinical research by enhancing understanding of human pathophysiology; however, there is still a continuous need to improve methods for evaluating disease...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29181736/adoptive-induced-antigen-specific-treg-cells-reverse-inflammation-in-collagen-induced-arthritis-mouse-model
#10
Guangzhi Sun, Yanfeng Hou, Wang Gong, Sai Liu, Jia Li, Yao Yuan, Dunfang Zhang, Qianming Chen, Xinfeng Yan
Rheumatoid arthritis (RA) is a systemic autoimmune disease that may cause bone damage and worsening disability. Manipulating antigen-specific Treg cells is a promising approach to treat autoimmune disease since the immune suppressive function of Treg cells has the feature of antigen specificity which could avoid overall immune suppression. It has been known that the function of Treg cells is impaired in RA, and adoptive transfer of Treg cells is effective in suppressing RA. Here, we designed a new approach to generate antigen-specific Treg cells by culturing CD4+ T cells from mice with RA onset, and we also proved that the adoptive transfer of these antigen-specific Treg cells reversed the collagen-induced arthritis (CIA) progression by suppressing the key inflammatory cytokine TNF-α...
November 27, 2017: Inflammation
https://www.readbyqxmd.com/read/29170107/analytical-and-clinical-comparison-of-two-fully-automated-immunoassay-systems-for-the-detection-of-autoantibodies-to-extractable-nuclear-antigens
#11
Pieter van der Pol, Liesbeth E Bakker-Jonges, Jac H S A M Kuijpers, Marco W J Schreurs
BACKGROUND: Detection of antinuclear antibodies (ANA) by indirect immunofluorescence assay (IIFA) is increasingly substituted by fully automated solid phase immunoassays. This study evaluated the performance of an automated chemiluminescence immunoassay (CIA) and fluorescence enzyme immunoassay (FEIA) and compared their performance to that of IIFA. METHODS: The study included an unselected prospective study population suspected of systemic autoimmune rheumatic disease...
November 21, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29163010/an-axiology-of-information-security-for-futuristic-neuroprostheses-upholding-human-values-in-the-context-of-technological-posthumanization
#12
Matthew E Gladden
Previous works exploring the challenges of ensuring information security for neuroprosthetic devices and their users have typically built on the traditional InfoSec concept of the "CIA Triad" of confidentiality, integrity, and availability. However, we argue that the CIA Triad provides an increasingly inadequate foundation for envisioning information security for neuroprostheses, insofar as it presumes that (1) any computational systems to be secured are merely instruments for expressing their human users' agency, and (2) computing devices are conceptually and practically separable from their users...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29161371/long-term-remineralizing-effect-of-mi-paste-plus-on-regression-of-early-caries-after-orthodontic-fixed-appliance-treatment-a-12-month-follow-up-randomized-controlled-trial
#13
Moniek W Beerens, Jacob M Ten Cate, Mark J Buijs, Monique H van der Veen
Background: Casein-phosphopeptide-amorphous-calcium-fluoride-phosphate (CPP-ACFP) can remineralize subsurface lesions. It is the active ingredient of MI-Paste-Plus® (MPP). The long-term remineralization efficacy is unknown. Objective: To evaluate the long-term effect of MPP versus a placebo paste on remineralization of enamel after fixed orthodontic treatment over a 12-month period. Design: This trial was designed as a prospective, double-blinded, placebo-controlled RCT...
November 17, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29161065/from-nuremberg-to-guantanamo-bay-uses-of-physicians-in-the-war-on-terror
#14
Sondra S Crosby, Gilbert Benavidez
Seventy years after the Nuremberg Doctors' Trial, health professionals and lawyers working together after 9/11 played a critical role in designing, justifying, and carrying out the US state-sponsored torture program in the CIA "Black Sites" and US military detention centers, including Abu Ghraib, Bagram, and Guantanamo Bay, Cuba. We analyze the similarities between the Nazi doctors and health professionals in the War on Terror and address the question of how it happened that health professionals, including doctors, psychologists, physician assistants, and nurses, acted as agents of the state to utilize their medical and healing skills to cause harm and sanitize barbarous acts, similar to (though not on the scale of) how Nazi doctors were used by the Third Reich...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29160881/effect-of-nobiletin-on-the-mapk-nf-%C3%AE%C2%BAb-signaling-pathway-in-the-synovial-membrane-of-rats-with-arthritis-induced-by-collagen
#15
Guliang Yang, Shiming Li, Li Yuan, Yiwen Yang, Min-Hsiung Pan
Nobiletin (5,6,7,8,3',4'-hexamethoxyflavone) is a natural compound in the fruit peel of citrus fruit in the Rutaceae family. It is active in inhibiting inflammation, reducing plasma lipids and has anti-oxidative properties. In studying the effect of nobiletin on rheumatoid arthritis (RA), the collagen-induced arthritis (CIA) model on Sprague-Dawley (SD) rats was established by bovine type II collagen (BIIC), and the effect of nobiletin on RA was investigated using hematoxylin-eosin (H&E) staining, serum enzyme linked immunosorbent assay (ELISA) detection and western blotting...
November 21, 2017: Food & Function
https://www.readbyqxmd.com/read/29152095/tipe2-expression-is-increased-in-peripheral-blood-mononuclear-cells-from-patients-with-rheumatoid-arthritis
#16
Zhu Shi-Bai, Liu Rui-Min, Sun Ying-Chuan, Zhai Jie, Jiang Chao, Ye Can-Hua, Chen Xi, Qian Wen-Wei
We investigated the changes in mRNA and protein expression of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) and PEST-containing nuclear protein (PCNP) in peripheral blood lymphocytes from 54 patients with rheumatoid arthritis (RA) and the spleens of model mice with collagen-induced arthritis (CIA) to generate new ideas for clinical diagnosis and treatment. Expression levels of both TIPE2 and PCNP were higher in RA patients and CIA mice than in their respective controls. They were also higher in the 32 patients with active RA than in the 22 with inactive RA (P < 0...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29149703/quercetin-attenuates-collagen-induced-arthritis-by-restoration-of-th17-treg-balance-and-activation-of-heme-oxygenase-1-mediated-anti-inflammatory-effect
#17
Yan Yang, Xu Zhang, Min Xu, Xin Wu, Feipeng Zhao, Chengzhi Zhao
Quercetin (QU) has been shown obvious anti-arthritic property in pre-clinical studies or clinical studies. Howbeit, the underlying mechanism of it is still not revealed distinctly and should be gotten further insight into. QU at a dosage of 150 mg/kg was administered orally in collagen-induced arthritis rats and then the clinical symptoms were monitored. The protein levels of Th17/Treg-related cytokines were determined by ELISA, and the mRNA levels of cytokines and transcription factors associated with the Th17 and Treg phenotypes were evaluated by real-time PCR, the proportions of Th17 and Treg cells were assessed by flow cytometry...
November 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29145862/l161982-alleviates-collagen-induced-arthritis-in-mice-by-increasing-treg-cells-and-down-regulating-interleukin-17-and-monocyte-chemoattractant-protein-1-levels
#18
Liang Chen, Xianglei Wu, Jun Zhong, Dongqing Li
BACKGROUND: To investigate the effects and potential mechanism of L161982 (a kind of EP4 antagonist) on the collagen-induced arthritis (CIA) mice model. METHODS: The CIA mice model were first established by immunizing with Chicken Type II Collagen on DBA/1 mice. The CIA groups were administered once a day for 2 weeks with either 5 mg/kg L161982 by intraperitoneal injections (IP), 200 U celecoxib by intragastrical injections, or 100 μl PBS (IP). At the end of the study, total arthritis score and histopathologic examination were assessed to determine CIA severity...
November 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29143269/defining-information-security
#19
Björn Lundgren, Niklas Möller
This article proposes a new definition of information security, the 'Appropriate Access' definition. Apart from providing the basic criteria for a definition-correct demarcation and meaning concerning the state of security-it also aims at being a definition suitable for any information security perspective. As such, it bridges the conceptual divide between so-called 'soft issues' of information security (those including, e.g., humans, organizations, culture, ethics, policies, and law) and more technical issues...
November 15, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29142301/alteration-of-the-intestinal-microbiome-characterizes-preclinical-inflammatory-arthritis-in-mice-and-its-modulation-attenuates-established-arthritis
#20
Rebecca Rogier, Heather Evans-Marin, Julia Manasson, Peter M van der Kraan, Birgitte Walgreen, Monique M Helsen, Liduine A van den Bersselaar, Fons A van de Loo, Peter L van Lent, Steven B Abramson, Wim B van den Berg, Marije I Koenders, Jose U Scher, Shahla Abdollahi-Roodsaz
Perturbations of the intestinal microbiome have been observed in patients with new-onset and chronic autoimmune inflammatory arthritis. However, it is currently unknown whether these alterations precede the development of arthritis or are rather a consequence of disease. Modulation of intestinal microbiota by oral antibiotics or germ-free condition can prevent arthritis in mice. Yet, the therapeutic potential of modulation of the microbiota after the onset of arthritis is not well characterized. We here show that the intestinal microbial community undergoes marked changes in the preclinical phase of collagen induced arthritis (CIA)...
November 15, 2017: Scientific Reports
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