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https://www.readbyqxmd.com/read/28539647/physiological-concentrations-of-soluble-uric-acid-are-chondroprotective-and-anti-inflammatory
#1
Jenn-Haung Lai, Shue-Fen Luo, Li-Feng Hung, Chuan-Yueh Huang, Shiu-Bii Lien, Leou-Chyr Lin, Feng-Cheng Liu, B Linju Yen, Ling-Jun Ho
High uric acid levels are a risk factor for cardiovascular disorders and gout; however, the role of physiological concentrations of soluble uric acid (sUA) is poorly understood. This study aimed to clarify the effects of sUA in joint inflammation. Both cell cultures of primary porcine chondrocytes and mice with collagen-induced arthritis (CIA) were examined. We showed that sUA inhibited TNF-α- and interleukin (IL)-1β-induced inducible nitric oxide synthase, cyclooxygenase-2 and matrix metalloproteinase (MMP)-13 expression...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539269/ursodeoxycholic-acid-attenuates-experimental-autoimmune-arthritis-by-targeting-th17-and-inducing-pampk-and-transcriptional-corepressor-smile
#2
Eun Jung Lee, Jeong-Eun Kwon, Min-Jung Park, KyungAh Jung, Da-Som Kim, Eun-Kyung Kim, Seung Hoon Lee, Jong Young Choi, Sung-Hwan Park, Mi-La Cho
BACKGROUND: Ursodeoxycholic acid (UDCA), also known ursodiol, is a secondary bile acid. It has been known that UDCA has prominent effects on liver, however, there is little known about its influence on autoimmune disease. Here, the benefit of UDCA on arthritis rheumatoid (RA) in vivo was tested. METHODS: RA mouse were induced using collagen II (CIA, collagen induced arthritis) where the disease severity or UDCA-related signaling pathway such as AMP-activated protein kinase (AMPK) or small heterodimer partner interacting leucine zipper protein (SMILE) was evaluated by westerblot and immunohistochemical staining...
May 21, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28539047/identifying-the-protein-interactions-of-the-cytosolic-iron-sulfur-cluster-targeting-complex-essential-for-its-assembly-and-recognition-of-apo-targets
#3
Amanda Thuy Van Vo, Nicholas M Fleischman, Mary J Froehlich, Claudia Y Lee, Jessica A Cosman, Calina A Glynn, Zanub O Hassan, Deborah L Perlstein
The cytosolic iron sulfur cluster assembly (CIA) system assembles iron sulfur (FeS) cluster cofactors and inserts them into >20 apo-protein targets residing in the cytosol and nucleus. Three CIA proteins, called Cia1, Cia2, and Met18 in yeast, form the targeting complex responsible for apo-target recognition. There is little information about the structure of this complex or its mechanism of CIA substrate recognition. Herein, we exploit affinity co-purification and size exclusion chromatography to determine the subunit connectivity and stoichiometry of the CIA targeting complex...
May 25, 2017: Biochemistry
https://www.readbyqxmd.com/read/28535900/possible-links-between-osteoporosis-and-periodontal-disease
#4
Daniela Cia Penoni, Anna Thereza Thomé Leão, Tatiana Melo Fernandes, Sandra Regina Torres
No abstract text is available yet for this article.
May 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28522406/therapeutic-effect-of-cryptotanshinone-on-experimental-rheumatoid-arthritis-through-downregulating-p300-mediated-stat3-acetylation
#5
Ying Wang, Chun Zhou, Hui Gao, Cuixian Li, Dong Li, Peiqing Liu, Min Huang, Xiaoyan Shen, Liang Liu
BACKGROUND AND PURPOSE: The balance between T helper 17 (Th17) cells and regulatory T (Treg) cells, plays a critical role in rheumatoid arthritis (RA). The differentiation of Th17 cells requires the activation of STAT3, which determines the balance of Th17/Treg. Here, we investigated the therapeutic effect of Cryptotanshinone (CTS) on collagen induced mouse arthritis and explored the underlying mechanisms. EXPERIMENTAL APPROACH: Arthritis was induced in DBA/1 mice with bovine collagen type II and complete Freund's adjuvant...
May 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28515692/wu-tou-decoction-in-rheumatoid-arthritis-integrating-network-pharmacology-and-in-vivo-pharmacological-evaluation
#6
Qingqing Guo, Kang Zheng, Danping Fan, Yukun Zhao, Li Li, Yanqin Bian, Xuemei Qiu, Xue Liu, Ge Zhang, Chaoying Ma, Xiaojuan He, Aiping Lu
Purpose: This study aimed to explore underlying action mechanism of Wu-Tou decoction (WTD) in rheumatoid arthritis (RA) through network pharmacology prediction and experimental verification. Methods: Chemical compounds and human target proteins of WTD as well as RA-related human genes were obtained from TCM Database @ Taiwan, PubChem and GenBank, respectively. Subsequently, molecular networks and canonical pathways presumably involved in the treatment of WTD on RA were generated by ingenuity pathway analysis (IPA) software...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28515324/the-diferric-tyrosyl-radical-cluster-of-ribonucleotide-reductase-and-cytosolic-iron-sulfur-clusters-have-distinct-and-similar-biogenesis-requirements
#7
Haoran Li, Martin Stümpfig, Caiguo Zhang, Xiuxiang An, JoAnne Stubbe, Roland Lill, Mingxia Huang
How each metalloprotein assembles the correct metal at the proper binding site presents challenges to the cell. The di-iron enzyme ribonucleotide reductase (RNR) uses a diferric-tyrosyl radical (Fe(III)2-Y·) cofactor to initiate nucleotide reduction. Assembly of this cofactor requires O2, Fe(II), and a reducing equivalent. Recent studies show that RNR cofactor biosynthesis shares the same source of iron, in the form of [2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for maturation of [4Fe-4S] clusters in cytosolic and nuclear proteins...
May 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28505087/the-effect-of-diet-on-the-survival-of-patients-with-chronic-kidney-disease
#8
REVIEW
Jacek Rysz, Beata Franczyk, Aleksandra Ciałkowska-Rysz, Anna Gluba-Brzózka
The prevalence of chronic kidney disease (CKD) is high and it is gradually increasing. Individuals with CKD should introduce appropriate measures to hamper the progression of kidney function deterioration as well as prevent the development or progression of CKD-related diseases. A kidney-friendly diet may help to protect kidneys from further damage. Patients with kidney damage should limit the intake of certain foods to reduce the accumulation of unexcreted metabolic products and also to protect against hypertension, proteinuria and other heart and bone health problems...
May 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28504901/tale-of-two-erythropoiesis-stimulating-agents-utilization-dosing-litigation-and-costs-of-darbepoetin-and-epoetin-among-south-carolina-medicaid-covered-patients-with-cancer-and-chemotherapy-induced-anemia
#9
Virginia Noxon, Kevin B Knopf, LeAnn B Norris, Brian Chen, Y Tony Yang, Zaina P Qureshi, William Hrushesky, Akida A Lebby, Benjamin Schooley, Neset Hikmet, Michael Dickson, Mae Thamer, Dennis Cotter, Paul R Yarnold, Charles L Bennett
PURPOSE: The US Food and Drug Administration (FDA) has approved epoetin and darbepoetin for chemotherapy-induced anemia (CIA). Approved epoetin and darbepoetin dosing schedules were three times per week and weekly, respectively, although off-label, less frequent scheduling was common. In 2004, 2007, and 2008, a US Food and Drug Administration Advisory Committees warned of risks associated with erythropoiesis-stimulating agents. During this period, lawsuits alleging illegal darbepoetin marketing practices have concluded, resulting in $1...
May 15, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28503699/eating-psychopathology-and-psychosocial-impairment-in-patients-treated-at-a-singapore-eating-disorders-treatment-programme
#10
Kah Wee Ng, Angeline Kuek, Huei Yen Lee
INTRODUCTION: There is limited data on the psychopathology of eating disorders in Singapore. This study: (a) describes levels of eating psychopathology and psychosocial impairment among individuals diagnosed with eating disorders at our hospital; and (b) compares the related psychopathology of these patients. METHODS: Between 1 August 2010 and 31 July 2012, 257 individuals who met the diagnostic criteria for eating disorders completed the Eating Disorder Examination Questionnaire (EDE-Q) and Clinical Impairment Assessment questionnaire (CIA)...
May 15, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28500877/clinically-isolated-aortitis-pitfalls-progress-and-possibilities
#11
REVIEW
Ilkay Cinar, He Wang, James R Stone
Non-infectious aortitis may be caused by several distinct systemic rheumatologic diseases. In some patients, aortitis is identified either pathologically or radiologically in the absence of clinical evidence of a systemic vasculitis. By consensus nomenclature, such cases are referred to as clinically isolated aortitis (CIA). Some systemic disorders may initially present as CIA including giant cell arteritis (GCA), IgG4-related disease, infectious aortitis, and granulomatosis with polyangiitis. CIA most commonly occurs in women of European descent over the age of 50 and, thus, mirrors the gender, age, and geographic distribution of GCA...
April 23, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28497863/ctla-4-expressed-by-foxp3-treg-cells-prevents-inflammatory-tissue-attack-and-not-t-cell-priming-in-arthritis
#12
Katrin Klocke, Rikard Holmdahl, Kajsa Wing
Cytotoxic T-lymphocyte antigen 4 (CTLA-4)-mediated regulation of already tolerized autoreactive T cells is critical for understanding autoimmune responses. While defects in CTLA-4 contribute to abnormal FOXP3(+) regulatory T cell (Treg) function in rheumatoid arthritis (RA) its role in autoreactive T cells remains elusive. We studied immunity towards the dominant collagen type-II (CII) T cell epitope in collagen-induced arthritis (CIA) both in the heterologous setting and in the autologous setting where CII is mutated at position E266D in mouse cartilage...
May 12, 2017: Immunology
https://www.readbyqxmd.com/read/28492384/effect-of-dexmedetomidine-and-propofol-on-basal-ganglia-activity-in-parkinson-disease-a-controlled-clinical-trial
#13
Antonio Martinez-Simon, Manuel Alegre, Cristina Honorato-Cia, Jorge M Nuñez-Cordoba, Elena Cacho-Asenjo, Iñaki F Trocóniz, Mar Carmona-Abellán, Miguel Valencia, Jorge Guridi
BACKGROUND: Deep brain stimulation electrodes can record oscillatory activity from deep brain structures, known as local field potentials. The authors' objective was to evaluate and quantify the effects of dexmedetomidine (0.2 μg·kg·h) on local field potentials in patients with Parkinson disease undergoing deep brain stimulation surgery compared with control recording (primary outcome), as well as the effect of propofol at different estimated peak effect site concentrations (0.5, 1...
April 7, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28484460/intralymphatic-administration-of-adipose-mesenchymal-stem-cells-reduces-the-severity-of-collagen-induced-experimental-arthritis
#14
Pablo Mancheño-Corvo, Mercedes Lopez-Santalla, Ramon Menta, Olga DelaRosa, Francisca Mulero, Borja Del Rio, Cristina Ramirez, Dirk Büscher, Juan A Bueren, Juan Lopez-Belmonte, Wilfried Dalemans, Marina I Garin, Eleuterio Lombardo
Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues associated with the inflammatory site where functional MSC-induced immune cells with a regulatory phenotype were increased mediating the immunomodulatory effects of MSCs. These results suggest that homing of MSCs to the lymphatic system plays an important role in the mechanism of action of MSCs in vivo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28480183/anatomic-and-clinical-risk-factors-for-pulmonary-embolism-in-patients-with-deep-venous-thrombosis-of-the-lower-extremity
#15
Bomina Paik, Jin Hyun Joh, Ho-Chul Park
PURPOSE: Iliac vein compression is a known culprit of deep vein thrombosis (DVT). In contrast, the compression may prevent the pulmonary embolism (PE). The aim of this study was to evaluate the anatomic and clinical risk factors of PE in patients with lower extremity DVT. METHODS: PE was evaluated using chest computed tomography in patients with lower extremity DVT. The patients were classified into group I (DVT without PE) and group II (DVT with PE) and analyzed to clarify the anatomic and clinical risk factors associated with PE in patients with DVT...
May 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28479440/gender-related-differences-in-iliofemoral-arterial-anatomy-among-aaa-patients
#16
Kenneth Tran, Chelsea Dorsey, Jason T Lee, Venita Chandra
OBJECTIVES: Gender related differences in iliofemoral anatomy are critically important for delivery of modern EVAR devices, however remains poorly characterized in the context of other patient-specific factors. The goal of the present study was to provide a detailed quantification of anatomic differences in iliofemoral anatomy between genders while controlling for height, weight and vascular comorbidities. METHODS: Fifty women with CT-angiograms for evaluation of AAA between 2000-2012 were selected and matched to an equal non-paired cohort of males with similar age, body-mass indices (BMI), and prevalence of vascular comorbidities (e...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28474155/n-2-hydroxyphenyl-acetamide-a-novel-suppressor-of-rank-rankl-pathway-in-collagen-induced-arthritis-model-in-rats
#17
Anum Gul, Bimal Kunwar, Maryam Mazhar, Kahkashan Perveen, Shabana U Simjee
RANKL and RANK are potential contributors of inflammatory cascade in human and animal model of arthritis. The current study aims to investigate the effect of N-(2-hydroxyphenyl)acetamide (NA-2) on regulation of RANKL pathway in collagen-induced arthritis (CIA) model in rats. CIA was induced using bovine type II collagen in female Wistar rats. The clinical parameters, level of pro-inflammatory and oxidative stress markers were measured to determine the progression of the disease. The mRNA level of RANKL and RANK and downstream mediators of inflammation i...
May 4, 2017: Inflammation
https://www.readbyqxmd.com/read/28463993/periploca-forrestii-saponin-ameliorates-cia-via-suppressing-proinflammatory-cytokines-and-nuclear-factor-kappa-b-pathways
#18
Chunmei Bao, Yingqin Liu, Xin Sun, Congcong Xing, Luting Zeng, Guangchen Sun
OBJECTIVE: Periploca forrestii Schltr has been used as a Chinese folk medicine for the treatment of rheumatism, arthralgia and fractures. However, the anti-arthritic activity of Periploca forrestii saponin (PFS) and the active compound has still not been revealed. This study aimed to investigate the protective effects and mechanisms of PFS on collagen type II (CII) collagen-induced arthritis (CIA) mice. We sought to investigate whether PFS and Periplocin could regulate osteoclastogenesis, and if so, further investigation on its mechanism of action...
2017: PloS One
https://www.readbyqxmd.com/read/28458196/moisture-variation-inferred-from-a-nebkha-profile-correlates-with-vegetation-changes-in-the-southwestern-mu-us-desert-of-china-over-one-century
#19
Jinchang Li, Yanfang Zhao, Liuyan Han, Guoming Zhang, Rentao Liu
We inferred moisture variations from the early 1930s to the early 2010s in the southwestern Mu Us Desert of China using Rb/Sr ratio, chemical index of alteration (CIA), and organic matter (OM) content in a nebkha profile. Our results showed that the variations in moisture may have been the main factor that controlled vegetation recovery or degradation, and we believe that gradual vegetation recovery was notable throughout the study area during the past 80years, despite two notable degradation stages during the mid-1950s and the mid-1980s...
April 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28457098/crystal-induced-arthropathy-in-elderly-patients-hospitalized-for-acute-conditions
#20
Andrew Villion, Zeev Arinzon, Jacob Feldman, Oded Kimchi, Yitshal Berner
BACKGROUND: Arthritis and arthralgia are painful symptoms experienced by many elderly patients during hospitalization. Crystal-induced arthritis (CIA) is one of the most common causes of arthritis worldwide and represents the most common cause of acute arthritis in the elderly. OBJECTIVES: To determine the incidence of both acute new onset or acute exacerbation of CIA among elderly patients hospitalized due to an acute medical illness. METHODS: This study comprised 85 patients...
March 2017: Israel Medical Association Journal: IMAJ
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