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https://www.readbyqxmd.com/read/28624279/the-use-of-national-level-data-to-describe-trends-in-intramammary-antimicrobial-usage-on-irish-dairy-farms-from-2003-to-2015
#1
Simon J More, Tracy A Clegg, Finola McCoy
In this study, we used national-level data to describe trends in on-farm intramammary antimicrobial usage in Ireland from 2003 to 2015. We calculated actual sales of intramammary tubes and the quantity of active substance sold, by year, product type [lactation or dry cow therapy (DCT)], antimicrobial group, World Health Organization antimicrobial classification, and from 2009 to 2015, prescribing route. We also estimated on-farm usage of lactation and dry cow intramammary antimicrobials using defined daily dose (DDDvet) and defined course dose (DCDvet) calculations, and dry cow coverage...
June 14, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28618762/antiinflammatory-and-antioxidant-effects-of-gemcitabine-in-collagen-induced-arthritis-model
#2
Adile Ferda Dağli, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Metin Özgen, Kazım Şahin, Süleyman Serdar Koca
BACKGROUND/AIM: Gemcitabine (GEM) has antiproliferative effects on lymphocytes, which are potent pathogenic actors of rheumatoid arthritis (RA). The aim of the study was to investigate the therapeutic potential of GEM on collagen-induced arthritis (CIA). MATERIALS AND METHODS: Arthritis was induced by the intradermal injection of chicken type II collagen with incomplete Freund's adjuvant into albino Wistar rats. Doses of 5 and 20 mg/kg GEM were administered twice a week after the 14th day, which marked the onset the arthritis...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28617559/blockade-of-il-17-alleviated-inflammation-in-rat-arthritis-and-mmp-13-expression
#3
X-L Shui, W Lin, C-W Mao, Y-Z Feng, J-Z Kong, S-M Chen
OBJECTIVE: Rheumatoid arthritis (RA) is one systemic auto-immune disorder featured as chronic synovitis and can destruct joint cartilage. Fibroblast-like synoviocyte (FLS) secretes various factors affecting chondrocyte matrix and degradation. This study thus investigated the effect of interleukin-17A (IL-17A) on FLS and osteoclast. MATERIALS AND METHODS: Type II collagen-induced arthritis (CIA) rats were assigned to CIA model, CIA + IgG1 isotype, and CIA + Anti-Rat IL-17A groups...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28615450/cellular-requirements-for-iron-sulfur-cluster-insertion-into-the-antiviral-radical-sam-protein-viperin
#4
Arunkumar S Upadhyay, Oliver Stehling, Christakis Panayiotou, Ralf Rösser, Roland Lill, Anna K Överby
Viperin (RSAD2) is an interferon-stimulated antiviral protein that belongs to the radical S-adenosyl methionine (SAM) enzyme family. Viperin's iron-sulfur (Fe/S) cluster is critical for its antiviral activity against many different viruses. CIA1 (CIAO1), an essential component of the cytosolic iron-sulfur protein assembly (CIA) machinery, is crucial for Fe/S cluster insertion into viperin and hence for viperin's antiviral activity. In the CIA pathway, CIA1 cooperates with CIA2A, CIA2B, and MMS19 targeting factors to form various complexes that mediate the dedicated maturation of specific Fe/S recipient proteins...
June 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28615031/leucine-rich-alpha-2-glycoprotein-promotes-th17-differentiation-and-collagen-induced-arthritis-in-mice-through-enhancement-of-tgf-%C3%AE-smad2-signaling-in-na%C3%A3-ve-helper-t-cells
#5
Hayato Urushima, Minoru Fujimoto, Takashi Mishima, Tomoharu Ohkawara, Hiromi Honda, Hyun Lee, Hirohisa Kawahata, Satoshi Serada, Tetsuji Naka
BACKGROUND: Leucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, LRG binds with transforming growth factor (TGF)-β and enhances Smad2 phosphorylation. Considering that the imbalance between T helper 17 (Th17) cells and regulatory T cells (Treg) plays important roles in the pathogenesis of RA, LRG may affect arthritic pathology by enhancing the TGF-β-Smad2 pathway that is pivotal for both Treg and Th17 differentiation...
June 14, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28607955/wound-healing-protects-against-chemotherapy-induced-alopecia-in-young-rats-via-up-regulating-interleukin-1%C3%AE-mediated-signaling
#6
Olivera Stojadinovic, Tongyu C Wikramanayake, Alexandra C Villasante Fricke, Natalie C Yin, Liang Liang, Eleanor Hinde, Julia Escandon, Marjana Tomic-Canic, David M Ansell, Ralf Paus, Joaquin J Jimenez
Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28593630/investigating-the-dsm-5-severity-specifiers-based-on-thinness-for-adults-with-anorexia-nervosa
#7
Deborah Lynn Reas, Øyvind Rø
OBJECTIVE: The DSM-5 severity classification scheme for adults with anorexia nervosa (AN) is based upon current body mass index (BMI; kg/m(2) ). This study examined the utility of the DSM-5 severity specifiers for adults with AN in relation to core cognitive and behavioral features of eating pathology and associated psychosocial impairment. METHODS: A clinical sample of 146 adult AN patients (140 women, 6 men) were categorized using DSM-5 current BMI severity specifiers and assessed with the Eating Disorder Examination-Questionnaire (EDE-Q) and Clinical Impairment Assessment (CIA)...
June 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28591946/-the-effects-of-all-trans-retinoic-acid-on-the-expression-of-inflammatory-cytokines-and-cartilage-damage-related-protease-in-rats-with-collagen-induced-arthritis
#8
Xue-Jian Xie, Yu-Yan Shen, Jie Song, Ling-Yu Zhong, Yan-Hua Ning, Xiang Zeng, Jing-Yan Shan, Yang Liu, Yan-Feng Zhu, Yun Li
OBJECTIVES: To investigate the effects of all-trans retinoic acid (ATRA) on arthritis and the expressions of inflammatory cytokines and cartilage damage related proteases of the collagen-induced arthritis model (CIA) rats in vivo. METHODS: The CIA model of rheumatoid arthritis was induced with C2 and incomplete Freund's adjuvant. The rats were randomly divided into control group, CIA model group and two ATRA dose groups (ATRA 0.50 mg/kg group and ATRA 1.00 mg/kg group)...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28584977/andrographolide-benefits-rheumatoid-arthritis-via-inhibiting-mapk-pathways
#9
Zun-Zhong Li, Ju-Peng Tan, Li-Li Wang, Qing-Hua Li
Andrographolide (AD) is the main compound distributed in medicinal herb Andrographis paniculata and exhibits anti-inflammatory activity. AD has been used for the treatment of multiple inflammatory diseases. However, the therapeutic value of AD on human rheumatoid arthritis (RA) remains unclear. In this study, we investigated the effects of AD on collagen-induced arthritis (CIA) and human RA synovial fibroblasts (RA-SFs). CIA mice were treated with AD (dissolved in 0.5% CMC-Na, 100 mg/kg per day) or vehicle (0...
June 6, 2017: Inflammation
https://www.readbyqxmd.com/read/28578206/is-internet-addiction-transitory-or-persistent-incidence-and-prospective-predictors-of-remission-of-internet-addiction-among-chinese-secondary-school-students
#10
Joseph T F Lau, Anise M S Wu, Danielle L Gross, Kit-Man Cheng, Mason M C Lau
BACKGROUND: Internet addiction (IA) is prevalent among adolescents but it is potentially revertible. Only three Taiwan adolescent studies reported IA remission and a few related factors. We investigated incidence and predictors of remission among Hong Kong Chinese secondary school students with a 12-month longitudinal study. METHODS: IA was defined as Chen Internet Addiction Scale (CIAS) score>63. Validated measures were used to assess students' psychosocial wellbeing at baseline and follow-up...
May 29, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28577436/anti-inflammatory-effects-of-ursolic-acid-3-acetate-on-human-synovial-fibroblasts-and-a-murine-model-of-rheumatoid-arthritis
#11
Jong Yeong Lee, Jin Kyeong Choi, Na-Hee Jeong, Jeongsoo Yoo, Yeong Su Ha, Byungheon Lee, Hyukjae Choi, Pil-Hoon Park, Tae-Yong Shin, Taeg Kyu Kwon, Sang-Rae Lee, Soyoung Lee, Seung Woong Lee, Mun-Chual Rho, Sang-Hyun Kim
Ursolic acid (UA), a pentacyclic triterpenoid, is a common natural substance known to be effective in the treatment of inflammation, oxidative stress, and ulcers in arthritis. This study examined the effects of ursolic acid-3-acetate (UAA), a derivative of UA, on rheumatoid arthritis (RA) and verified the underlying mechanism of action by using a type-II collagen-induced arthritis (CIA) mice model and tumor necrosis factor (TNF)-α-stimulated RA synovial fibroblasts. The oral administration of UAA showed a decrease in clinical arthritis symptoms, paw thickness, histologic and radiologic changes, and serum IgG1 and IgG2a levels...
May 31, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28572711/buprenorphine-alters-inflammatory-and-oxidative-stress-molecular-markers-in-arthritis
#12
Mahadevappa Hemshekhar, Vidyanand Anaparti, Carol Hitchon, Neeloffer Mookherjee
Buprenorphine is recommended for use as an analgesic in animal models including in murine models of collagen-induced arthritis (CIA). However, the effect of buprenorphine on the expression of disease-associated biomarkers is not well defined. We examined the effect of buprenorphine administration on disease progression and the expression of inflammatory and oxidative stress markers, in a murine model of CIA. Buprenorphine administration altered the expression of cytokines, IFN-γ, IL-6, and MMP-3, and oxidative markers, for example, iNOS, superoxide dismutase (SOD1), and catalase (CAT), in the CIA mice...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28566090/lymphatic-delivery-of-etanercept-via-nanotopography-improves-response-to-collagen-induced-arthritis
#13
Melissa B Aldrich, Fred C Velasquez, Sunkuk Kwon, Ali Azhdarinia, Kenneth Pinkston, Barrett R Harvey, Wenyaw Chan, John C Rasmussen, Russell F Ross, Caroline E Fife, E M Sevick-Muraca
BACKGROUND: Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previously been shown to disrupt tight cellular junctions, potentially enhancing local lymphatic delivery and potentially improving overall therapeutic efficacy. METHOD: We first characterized nanotopography (SOFUSA™) delivery of an anti-TNF drug, etanercept, by comparing pharmacokinetic profiles to those obtained by conventional SC, intravenous (IV), and intradermal (ID) routes of administration, and assessed uptake of radiolabeled etanercept in draining lymph nodes (LNs) in single dosing studies...
May 31, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28565837/artesunate-influences-th17-treg-lymphocyte-balance-by-modulating-treg-apoptosis-and-th17-proliferation-in-a-murine-model-of-rheumatoid-arthritis
#14
Jia Liu, Xuezhi Hong, Dong Lin, Xiaohong Luo, Mengya Zhu, Hanyou Mo
CD4(+) regulatory T (Treg) cells and T-helper 17 (Th17) cells have been shown to have important roles in rheumatoid arthritis (RA). In our previous study, it was demonstrated that artesunate was able to alter the Treg/Th17 ratio in patients with RA; however, the underlying mechanisms remain unclear. The present study established a male Sprague Dawley (SD) rat model of type II collagen-induced arthritis (CIA). SD rats were divided into normal control, CIA model and artesunate-treated (5, 10 or 20 mg/kg/day) groups...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28562359/blockage-of-foxp3-transcription-factor-dimerization-and-foxp3-aml1-interaction-inhibits-t-regulatory-cell-activity-sequence-optimization-of-a-peptide-inhibitor
#15
Teresa Lozano, Marta Gorraiz, Aritz Lasarte-Cía, Marta Ruiz, Obdulia Rabal, Julen Oyarzabal, Sandra Hervás-Stubbs, Diana Llopiz, Pablo Sarobe, Jesús Prieto, Noelia Casares, Juan José Lasarte
Although T regulatory cells (Treg) are essential for the prevention of autoimmune diseases, their immunoregulatory function restrains the induction of immune responses against cancer. Thus, development of inhibitors of FOXP3, a key transcription factor for the immunosuppressive activity of Treg, might give new therapeutic opportunities. In a previous work we identified a peptide (named P60) able to enter into the cells, bind to FOXP3, and impair Treg activity in vitro and in vivo. Here we show that P60 binds to the intermediate region of FOXP3 and inhibits its homodimerization as well as its interaction with the transcription factor AML1...
May 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28560778/daily-oral-administration-of-low-dose-methotrexate-has-greater-antirheumatic-effects-in-collagen-induced-arthritis-rats
#16
Aoi Koyama, Aki Tanaka, Hideto To
OBJECTIVES: Methotrexate (MTX) is administered once or thrice weekly to patients with rheumatoid arthritis (RA). Even though RA continually progresses, MTX is not administered daily. Therefore, we investigated whether the daily administration of a low dose of MTX inhibits the progression of arthritis in collagen-induced arthritis (CIA) rats. METHODS: Methotrexate was orally administered once weekly, thrice weekly and once daily to CIA rats, and arthritis scores were measured...
May 31, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28560007/use-of-immune-modulation-by-human-adipose-derived-mesenchymal-stem-cells-to-treat-experimental-arthritis-in-mice
#17
Li Zhang, Xiao-Yan Wang, Peng-Jun Zhou, Zhe He, Hai-Zhao Yan, Dan-Dan Xu, Ying Wang, Wu-Yu Fu, Bi-Bo Ruan, Sheng Wang, Hai-Xuan Chen, Qiu-Ying Liu, Yu-Xia Zhang, Zhong Liu, Yi-Fei Wang
Rheumatoid arthritis is a chronic and systemic autoimmune disease characterized by inflammatory cell infiltration and joint erosion. Human adipose-derived mesenchymal stem cells (hASCs) have shown the capacity of suppressing effector T cell activation and inflammatory cytokine expression. We investigated whether hASCs play a therapeutic role in collagen-induced arthritis (CIA) by administering a single dose of hASCs in mice with established CIA. In vivo, a beneficial effect was observed following hASC infusion as shown by a marked decrease in the severity of arthritis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28559174/prospective-multicenter-study-of-endovascular-repair-of-aortoiliac-and-iliac-aneurysms-using-the-gore-iliac-branch-endoprosthesis
#18
Darren B Schneider, Jon S Matsumura, Jason T Lee, Brian G Peterson, Rabih A Chaer, Gustavo S Oderich
OBJECTIVE: The GORE EXCLUDER Iliac Branch Endoprosthesis (IBE; W. L. Gore and Associates, Flagstaff, Ariz) is an iliac branch stent graft system designed to preserve internal iliac artery perfusion during endovascular repair of aortoiliac aneurysms (AIAs) and common iliac artery (CIA) aneurysms (CIAAs). We report the 6-month primary end point results of the IBE 12-04 United States pivotal trial for endovascular treatment of AIAs and CIAAs using the IBE device. METHODS: The trial prospectively enrolled 63 patients with AIA or CIAA who underwent implantation of the IBE device at 28 centers in the United States from 2013 to 2015...
May 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28554370/measurement-invariance-across-genders-on-the-childhood-illness-attitude-scales-cias
#19
Audur S Thorisdottir, Anna Villadsen, Daniel M LeBouthillier, Charlotte Ulrikka Rask, Kristi D Wright, John R Walker, Steven Feldgaier, Gordon J G Asmundson
OBJECTIVE: The Childhood Illness Attitude Scales (CIAS) were created as a developmentally appropriate measure for symptoms of health anxiety (HA) in school-aged children. Despite overall sound psychometric properties reported in previous studies, more comprehensive examination of the latent structure and potential response bias in the CIAS is needed. The purpose of the present study was to cross-validate the latent structure of the CIAS across genders and to examine gender-specific variations in CIAS scores...
July 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28553850/how-the-three-arches-of-the-foot-intercorrelate
#20
Abdullahi Suleiman Gwani, Mohd Asnizam Asari, Zul Izhar Mohd Ismail
BACKGROUND: The foot is composed of medial, lateral and transverse arches which, particularly the medial arch, provide it with the ability to function both as a flexible and rigid structure for proper locomotion. Arches of the foot, as well as their effect on lower extremity function, have been studied. However, quantitative data on the relationship between these arches still remain scanty. The purpose of this study was, therefore, to examine how the three arches of the foot intercorrelate...
May 29, 2017: Folia Morphologica (Warsz)
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