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Walter Colangeli, Umberto Riccelli, Amerigo Giudice, Ida Barca, Davide Caruso, Daniela Novembre, Claudio Tortosa, Raffaella Cordaro, Maria Giulia Cristofaro
PURPOSE: Mesenchymal stem cells (MSC), which are multipotent stromal cells, are considered to be a promising resource in tissue engineering and tissue regeneration. MSCs have been used to generate new maxillary bone with clinically successful results. The aim of this study was to determine the role of MSC in bone regeneration procedures in patients with benign maxillary lesions. METHODS: A study was conducted on five patients treated for maxillary bone defects resulting from biopsy of benign lesions at the University Hospital of Magna Græcia, Catanzaro, Italy from January 2015 to October 2016...
2018: Annali Italiani di Chirurgia
Pengyan Xia, Shuo Wang, Buqing Ye, Ying Du, Chong Li, Zhen Xiong, Yuan Qu, Zusen Fan
Disrupting the balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) leads to bone marrow failure or hematologic malignancy. However, how HSCs sustain their quiescent state and avoid type I interferon (IFN)-mediated exhaustion remains elusive. Here we defined a circular RNA that we named cia-cGAS that was highly expressed in the nucleus of long-term (LT)-HSCs. Cia-cGAS deficiency in mice caused elevated expression of type I IFNs in bone marrow and led to decreased numbers of dormant LT-HSCs...
March 29, 2018: Immunity
Maria Infantino, M Manfredi, M Merone, V Grossi, M Benucci, F Li Gobbi, F Bandinelli, A Damiani, P Soda
Anti-dsDNA antibodies are a heterogeneous group of antibodies, quite specific for SLE. Their variability is related to the assay used, the immunoglobulin class secondary antibody, and the dsDNA source. The standardization of measuring anti-dsDNA antibodies is still poor and different methods yield different results. Several novel technologies were developed during the last decades that represent viable alternatives to the traditional methods such as the chemiluminescent immunoassay (CIA) and multiplex flow immunoassay (MFI)...
April 5, 2018: Immunologic Research
Douglas L Boggs, Toral Surti, Aarti Gupta, Swapnil Gupta, Mark Niciu, Brian Pittman, Ashley M Schnakenberg Martin, Halle Thurnauer, Andrew Davies, Deepak C D'Souza, Mohini Ranganathan
RATIONALE: Preliminary evidence suggests that cannabidiol (CBD) may be effective in the treatment of neurodegenerative disorders; however, CBD has never been evaluated for the treatment of cognitive impairments associated with schizophrenia (CIAS). OBJECTIVE: This study compared the cognitive, symptomatic, and side effects of CBD versus placebo in a clinical trial. METHODS: This study was a 6-week, randomized, placebo-controlled, parallel group, fixed-dose study of oral CBD (600 mg/day) or placebo augmentation in 36 stable antipsychotic-treated patients diagnosed with chronic schizophrenia...
April 5, 2018: Psychopharmacology
Nagaraja Haleagrahara, Kelly Hodgson, Socorro Miranda-Hernandez, Samuel Hughes, Anupama Bangra Kulur, Ketheesan Natkunum
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovial tissues in joints, leading to progressive destruction of cartilage and joints. The disease-modifying anti-rheumatic drugs currently in use have side-effects. Thus, there is an urgent need for safe anti-inflammatory therapies for RA. This study aimed to evaluate the therapeutic effect of the flavonoid quercetin on arthritis in mice immunized with type II collagen (CII). An arthritis model was established in C57/BL6 mice by intradermal administration of chicken CII mixed with Freund's complete adjuvant...
April 3, 2018: Inflammopharmacology
Jorge Peiró Cadahía, Jon Bondebjerg, Christian Abilgaard Hansen, Viola Previtali, Anders E Hansen, Thomas L Andresen, Mads Hartvig Clausen
A series of novel hydrogen peroxide sensitive prodrugs of methotrexate (MTX) and aminopterin (AMT) were synthesized and evaluated for therapeutic efficacy in mice with collagen induced arthritis (CIA) as a model of chronic rheumatoid arthritis (RA). The prodrug strategy selected is based on ROS-labile 4-methylphenylboronic acid promoieties linked to the drugs via a carbamate linkage or a direct C‒N bond. Activation under patho-physiological concentrations of H2O2 proved to be effective and prodrug candidates were selected in agreement with relevant in vitro physicochemical and pharmacokinetic assays...
March 31, 2018: Journal of Medicinal Chemistry
Tokumitsu Mihara, Shinji Tanishima, Atsushi Tanida, Ryota Teshima, Hideki Nagashima
Background: To histologically evaluate lumbar involvement in rheumatoid arthritis (RA) by investigating rats with collagen-induced arthritis (CIA) and to assess the potential effects of RA on the discovertebral joints and facet joints. Methods: Seven-month-old female Sprague-Dawley rats were divided into groups with CIA and without CIA (control). All rats were sacrificed at 8 weeks after initial sensitization and the lumbar spine (L5/6) was harvested. Then the lumbar spine block specimens were stained with Villaneuva bone stain and sectioned in the midsagittal plane...
March 2018: Yonago Acta Medica
Claude Schwartz
BACKGROUND: The aim of this study was to evaluate the possible complications specific to the continuous intraarticular anaesthesia (CIA) in a minimally invasive posterior approach in total hip arthroplasty and its possible effects on the recovery, especially on pain and the length of hospitalisation. MATERIALS AND METHODS: The surgical procedure is first precisely described step by step with numerous per-operating photographs. Particular technical points are detailed...
March 26, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Xiaofen He, Lei Huang, Shenchen Qiu, Xiaohu Yin, Yafang Shen, Yuanyuan Wu, Yongliang Jiang, Jianqiao Fang
The classical analgesic pathway of opioids by binding their receptors in the nervous system is well known. However, little is known regarding opioid analgesia through the anti-inflammatory pathway. The present study aimed to investigate the analgesic and anti-inflammatory effect of β-endorphin on inflammatory pain. A rat model of collagen-induced arthritis (CIA) was generated by intradermal injection of bovine type II collagen. Rats were divided into the CIA + saline group and the CIA + β-endorphin group, in which rats were intraperitoneally injected with β-endorphin once every other day from day 18 following the injection of CII until day 28...
April 2018: Experimental and Therapeutic Medicine
Vincent Panneton, Sahar Bagherzadeh Yazdchi, Mariko Witalis, Jinsam Chang, Woong-Kyung Suh
ICOS is a key costimulatory receptor facilitating differentiation and function of follicular helper T cells and inflammatory T cells. Rheumatoid arthritis patients were shown to have elevated levels of ICOS+ T cells in the synovial fluid, suggesting a potential role of ICOS-mediated T cell costimulation in autoimmune joint inflammation. In this study, using ICOS knockout and knockin mouse models, we found that ICOS signaling is required for the induction and maintenance of collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis...
March 26, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Paulo V G Alabarse, Priscila S Lora, Jordana M S Silva, Rafaela C E Santo, Eduarda C Freitas, Mayara S de Oliveira, Andrelise S Almeida, Mônica Immig, Vivian O N Teixeira, Lidiane I Filippin, Ricardo M Xavier
BACKGROUND: Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% of the patients. This can progress to severely debilitating state known as rheumatoid cachexia-without loss of fat mass and body weight-for which there is little consensus in terms of diagnosis or treatment. This study aims to evaluate whether the collagen-induced arthritis (CIA) animal model also develops clinical and functional features characteristic of rheumatoid cachexia...
March 25, 2018: Journal of Cachexia, Sarcopenia and Muscle
Kathryn M Harper, Darin J Knapp, Meredith A Park, George R Breese
Neuroimmune cytokines are increased with alcohol withdrawal and may mediate clinical responses associated with alcoholism. Because minocycline regulates the level of cytokines, it has been suggested as a therapeutic for disorders associated with alcohol. Male Wistar rats were exposed to chronic intermittent alcohol (CIA) comprising three 5-day cycles of ethanol liquid diet separated by 2 days of withdrawal. Rats were tested on social interaction, a measure of anxiety-like behavior, followed immediately by collection of amygdala tissue to measure CCL2 and TNFα or collection of the blood to measure corticosterone (CORT)...
March 20, 2018: Pharmacology, Biochemistry, and Behavior
Sang Hoon Jeong, Yoojun Nam, Hyerin Jung, Juryun Kim, Yeri Alice Rim, Narae Park, Kijun Lee, Seungjin Choi, Yeonsue Jang, Yena Kim, Ji-Hoi Moon, Seung Min Jung, Sung-Hwan Park, Ji Hyeon Ju
Rheumatoid arthritis (RA) is a chronic autoimmune disease that typically results in strong inflammation and bone destruction in the joints. It is generally known that the pathogenesis of RA is linked to cardiovascular and periodontal diseases. Though rheumatoid arthritis and periodontitis share many pathologic features such as a perpetual inflammation and bone destruction, the precise mechanism underlying a link between these two diseases has not been fully elucidated. Collagen-induced arthritis (CIA) mice were orally infected with Porphyromonas gingivalis (Pg) or Pg preincubated with an anti-FimA antibody (FimA Ab) specific for fimbriae that are flexible appendages on the cell surface...
March 23, 2018: Experimental & Molecular Medicine
Xinming Yun, Shu Dong, Qiaoqiao Hu, Yue Dai, Yufeng Xia
Tetrandrine is an effective ingredient isolated from the roots of a frequently used medicinal plant Stephania tetrandra S. Moore. It has been used for the management of arthritis in China, but the precise mechanism remains unclear. In the present study, a metabolomics method based on the1 H NMR was constituted to quantify the alterations of the endogenous metabolites in the urines of collagen-induced arthritis (CIA) rats treated with tetrandrine. Data showed that tetrandrine treatment could alleviate the ankle joint swelling and ameliorate histopathological changes in rats...
March 14, 2018: Journal of Pharmaceutical and Biomedical Analysis
Xingfei Li, Jie Long, Yufei Hua, Yeming Chen, Xiangzhen Kong, Caimeng Zhang
We first observed that protein/polysaccharide interaction exhibited non-interacting behavior which makes Bowman-Birk chymotrypsin inhibitor (BBI) always free of complexation, being separated from another protein with similar isoelectric points, Kunitz trypsin inhibitor (KTI). Turbidity titrations showed that, the electrostatic attractions were much stronger between KTI/BBI (KBi) and carboxymethyl cellulose of higher substitution degree. Unchanged chymotrypsin inhibitory activity (CIA) indicated that BBI had negligible contribution to protein recovery and trypsin inhibitory activity (TIA)...
March 22, 2018: Journal of Agricultural and Food Chemistry
Qiaozhen Peng, Weishe Zhang
RATIONALE: Placenta accreta is the main cause of severe obstetric postpartum hemorrhage (PPH) and hysterectomy. Several hemostatic techniques have been performed in patients with placenta accreta to prevent PPH and reserve fertility. Abdominal aorta and pelvic arteries balloon occlusion are the only techniques which could be performed before cesarean section (CS) in patients who want to keep the fetus and reserve fertility. However, abdominal aorta and pelvic arteries balloon occlusion might lead to severe complications such as formation and rupture of pseudoaneurysm, angiorrhexis, etc...
March 2018: Medicine (Baltimore)
Keumah Han, Jongbin Kim
Local anesthesia is administered to control pain, but it may induce fear and anxiety. Root planing is a non-surgical periodontal therapy; however, when it is performed in an extensive manner, some tissue removal is inevitable. Notably, this removal may be so painful that local anesthesia is required to be administered to the area scheduled for the treatment. Although patients tend to accept root planing easily, they frequently express a fear of local anesthesia. Intraosseous anesthesia (IA) is an intraosseous injection technique, whereby local anesthetic is injected into the cancellous bone supporting the teeth...
February 2018: Journal of Dental Anesthesia and Pain Medicine
Henry H Nguyen, Abdel Aziz Shaheen, Natalia Baeza, Ellina Lytvyak, Stefan J Urbanski, Andrew L Mason, Gary L Norman, Marvin J Fritzler, Mark G Swain
BACKGROUND AND AIMS: Up to 20% of Primary Biliary Cholangitis (PBC) patients are estimated to have features that overlap with Autoimmune Hepatitis (AIH). Patients with PBC-AIH overlap syndrome (PBC-AIH OS) have been reported to exhibit suboptimal responses to ursodeoxycholic acid therapy, and are more likely to progress to cirrhosis. Anti-double stranded DNA (anti-dsDNA) and anti-p53 have been previously suggested to be potential autoantibodies for identifying patients with PBC-AIH OS...
2018: PloS One
Mahmood Ahmad Khan, Mohd Jahir Khan
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, affecting almost 1% of world population. Although the exact cause of RA is not known but the complex interaction between inflammatory mediators like tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2) and nitric oxide (NO) is accountable for cartilage destruction in joints. Gold is used for arthritis treatment since long without knowing its mechanism of action. Hence, the present study was designed to assess antiarthritic activity of nanogold (AuNGs) in collagen-induced arthritic (CIA) rat model by virtue of decreasing inflammatory mediators and oxidative stress...
March 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Shu Yang, Zhihua Xing, Tao Liu, Jing Zhou, Qinghua Liang, Tao Tang, Hanjin Cui, Weijun Peng, Xingui Xiong, Yang Wang
Background: Rheumatoid arthritis (RA) is a common worldwide public health problem, which causes a chronic, systemic inflammatory disorder of synovial joints. Paeoniflorin (PA) has achieved positive results to some extent for the treatment of RA. Purpose: This study aimed to reveal the potential druggable targets of PA in an experimental RA model using quantitative proteomics analysis. Study design and methods: Thirty Sprague-Dawley rats were randomly divided into a normal group, model group and PA group...
2018: Drug Design, Development and Therapy
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