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Neuropathic ulcer

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https://www.readbyqxmd.com/read/29745908/local-use-of-granulocyte-macrophages-colony-stimulating-factor-in-treatment-of-chronic-diabetic-neuropathic-ulcer-case-review
#1
E Karlafti, Ch Savopoulos, A Hatzitolios, T Didangelos
One of the main causes of amputations in patients with Diabetes Mellitus patients is a chronic diabetic foot ulcer. The authors present a clinical case and discussion of a successful use of Granulocyte-Macrophages Colony Stimulating Factor (GM-CSF) treatment for the promotion of healing of a chronic diabetic foot ulcer. A 65 year-old woman was admitted to the Diabetes Center with complaints of a deep non-healing chronic foot ulcer for the last 18 months. At the examination a 5 cm ulcer on the plantar surface of the right foot was revealed...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29718812/safety-and-efficacy-of-an-autologous-blood-clot-product-in-the-management-of-texas-1a-or-2a-neuropathic-diabetic-foot-ulcers-a-prospective-multicenter-open-label-pilot-study
#2
Robert J Snyder, Maria A Kasper, Keyur Patel, Marissa J Carter, Igal Kushnir, Alon Kushnir, Thomas E Serena
OBJECTIVE: This pilot study evaluates safety in terms of the occurrence of adverse events (AEs) as well as the efficacy in terms of complete wound healing rates of a blood clot product when applied to chronic neuropathic diabetic foot ulcers (DFUs). MATERIALS AND METHODS: Participants were chosen from patients with DFUs visiting the wound care clinic. Up to 10 mL of blood drawn from each participant was injected into the product's clotting tray. Within 12 minutes, the blood clot product was formed, applied to the single DFU of each participant, and covered with primary and secondary dressings...
April 20, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29703224/factors-associated-with-amputation-among-patients-with-diabetic-foot-ulcers-in-a-saudi-population
#3
Imad R Musa, Mohanned O N Ahmed, Elsanousi Ibrahim Sabir, Ibrahim F Alsheneber, Elsayed M E Ibrahim, Gussay Badawi Mohamed, Rasha Elamin Awadallah, Tarig Abbas, Gasim Ibrahim Gasim
OBJECTIVES: A prospective study was conducted at the Armed Forces Hospital, Dhahran, Saudi Arabia, between January 2015 and December 2016 to identify the risk factors associated with amputation among diabetic foot ulcers DFUs patients. RESULTS: In total, 82 patients were recruited. Fifty-five of the patients were males (67.07%), the mean (SD) age of the participants was 60 (± 11.4) years, the mean duration of diabetes was 8.5 (± 3.7) years, and the mean haemoglobin A1c was 4...
April 27, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29698813/neuropathic-keratopathy
#4
REVIEW
Harminder S Dua, Dalia G Said, Elisabeth M Messmer, Maurizio Rolando, Jose M Benitez-Del-Castillo, Parwez N Hossain, Alex J Shortt, Gerd Gerling, Mario Nubile, Francisco C Figueiredo, Saaeha Rauz, Leonardo Mastropasqua, Paolo Rama, Christophe Baudouin
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor and trophic functions, which can be affected independently or simultaneously. Loss of trophic function and consequent epithelial breakdown exposes the stroma making it susceptible to enzymatic degradation. Nerve pathology can range from attrition to aberrant re-generation with corresponding symptoms from anaesthesia to hyperaesthesia/allodynia...
April 23, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29649067/outpatient-negative-pressure-wound-therapy-following-surgical-debridement-results-and-complications
#5
Eran Tamir, Aharon S Finestone, Itay Wiser, Yoram Anekstein, Gabriel Agar
OBJECTIVE: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT). METHODS: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT...
April 11, 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29581518/depressive-mood-in-individuals-with-spinal-cord-injury-sci-living-in-greece
#6
Ioannis-Alexandros Tzanos, Andreas Mavrogenis, Konstantina Gioti, Panagiotis Papaggeloppoulos, Elias Panagiotopoulos
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To provide data on depressive symptoms rates in the Greek SCI population and to investigate their association with demographic and clinical variables. SETTING: Greek territory. METHODS: One hundred and sixty-four individuals with SCI living in the community for at least 1 year after the completion of the primary inpatient rehabilitation program were included in the study...
March 26, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29569418/monitoring-of-ph-and-temperature-of-neuropathic-diabetic-and-non-diabetic-foot-ulcers-for-12-weeks-an-observational-study
#7
G Gethin, G M O'Connor, J Abedin, J Newell, L Flynn, D Watterson, A O'Loughlin
Wound bed assessment is largely reliant on subjective interpretation without recourse to objective tools or biomarkers. The identification of a point of care, reliable biomarker would enhance assessment and ultimately clinical decision-making. Two potentially emerging wound biomarkers exist: surface pH and surface temperature. To date, knowledge of their use has been predominantly in wound prevention, in vitro studies and single time measurements. Our objective was to determine surface pH, size and surface temperature in non-infected, neuropathic foot ulcers at baseline and at 12 weeks...
March 22, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29564750/the-proteolytic-fraction-from-latex-of-vasconcellea-cundinamarcensis-p1g10-enhances-wound-healing-of-diabetic-foot-ulcers-a-double-blind-randomized-pilot-study
#8
Luís A B Tonaco, Flavia L Gomes, Gustavo Velasquez-Melendez, Miriam T P Lopes, Carlos E Salas
INTRODUCTION: The aim of the study was to investigate the role of the proteolytic fraction from Vasconcellea cundinamarcensis, designated as P1G10, on the healing of chronic foot ulcers in neuropathic patients with diabetes 2. METHODS: Fifty patients were enrolled in a prospective, randomized, double-blind trial, to verify the efficacy and safety of a topical dressing formulated with 0.1% P1G10, intended for wound healing, versus a hydrogel (control) protocol. Upon completion of the intervention, the outcome evaluated the number of patients attaining full epithelization (100%), or at least 80% healing...
March 21, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29521643/clinic-based-debridement-of-chronic-ulcers-has-minimal-impact-on-bacteria
#9
Paul J Kim, Christopher E Attinger, Thomas Bigham, Robert Hagerty, Samantha Platt, Ersilia Anghel, John S Steinberg, Karen K Evans
Outpatient-based sharp debridement is considered an important element for the care of a chronic ulcer. OBJECTIVE: The aim of this study is to evaluate the change in bacterial amounts with sharp debridement in a clinical setting. MATERIALS AND METHODS: Bacterial autofluorescence, quantitative cultures, semiquantitative cultures, and qualitative speciation were performed predebridement and postdebridement during a single clinic visit. RESULTS: Thirty-six wounds were included in the analysis...
February 23, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29503134/squamous-cell-carcinoma-from-marjolin-s-ulcer-of-the-foot-in-a-diabetic-patient-case-study
#10
Raymond Cavaliere, Danielle M Mercado, Malary Mani
Squamous cell carcinoma (SCC) has been commonly reported by foot and ankle specialists. Marjolin's ulcer is a malignancy that involves a posttraumatic scar or ulceration that can develop into SCC from chronic neuropathic pedal wounds, venous stasis, or decubitus ulcerations. Most Marjolin's ulcers are found in the lower extremity, specifically the feet, and it is twice as common in females as males. Biopsy of the tumor is the reference standard to diagnose SCC, and wide excision of SCC is the most common treatment option...
March 2, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29481330/total-contact-cast-use-in-patients-with-peripheral-arterial-disease-a-case-series-and-systematic-review
#11
Anthony Tickner, Cheri Klinghard, Jonathan F Arnold, Valerie Marmolejo
INTRODUCTION: As the majority of diabetic foot ulcerations (DFUs) occur on the plantar foot, excessive pressure is a major contributing factor to delayed healing. The gold standard for offloading is the total contact cast (TCC); yet, TCC use is contraindicated in patients with ischemia. Lower extremity ischemia typically presents in the more severe end stages of peripheral arterial disease (PAD). As PAD exists on a severity spectrum from mild to severe, designation of a clear cutoff where TCC use is an absolute contraindication would assist those who treat DFUs on a daily basis...
February 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29477099/an-exploratory-study-on-differences-in-cumulative-plantar-tissue-stress-between-healing-and-non-healing-plantar-neuropathic-diabetic-foot-ulcers
#12
Jaap J van Netten, Jeff G van Baal, Adriaan Bril, Marieke Wissink, Sicco A Bus
BACKGROUND: Mechanical stress is important in causing and healing plantar diabetic foot ulcers, but almost always studied as peak pressure only. Measuring cumulative plantar tissue stress combines plantar pressure and ambulatory activity, and better defines the load on ulcers. Our aim was to explore differences in cumulative plantar tissue stress between people with healing and non-healing plantar diabetic foot ulcers. METHODS: We analyzed a subgroup of 31 patients from a randomized clinical trial, treated with a removable offloading device for their plantar diabetic forefoot ulcer...
March 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29438840/efficacy-and-safety-of-combined-low-doses-of-either-diclofenac-or-celecoxib-with-gabapentin-versus-their-single-high-dose-in-treatment-of-neuropathic-pain-in-rats
#13
Mohamed A Ibrahim, Walaa Yehia Abdelzaher, Remon R Rofaeil, Soha Abdelwahab
Neuropathic pain is a worldwide health problem with no consensus regarding its optimal therapy. This study compared the analgesic effect and gastric, hepatic, and renal safety of combined low doses of diclofenac and celecoxib with gabapentin versus their individual high doses in the treatment of neuropathic pain in rats. Left sciatic nerve ligation was used as neuropathic pain model. Rats were allocated into 7 groups (7 rats for each): sham control; model group (received vehicle); Gaba-group (received gabapentin (100 mg/kg /day); Diclo 10-group (received diclofenac (10 mg/kg); Cele 10-group (received celecoxib (10 mg/kg/day); Gaba + Diclo 5 (receivedgabapentin(100 mg/kg /day) plus diclofenac (5 mg/kg); Gaba + Cele 5 (received gabapentin (100 mg/kg/day) plus celecoxib (5 mg/kg))...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29409261/non-contact-ulcer-area-calculation-system-for-neuropathic-foot-ulcer
#14
Parth Shah, Siddaram Mahajan, Sharmila Nageswaran, Sathish Kumar Paul, Mannam Ebenzer
BACKGROUND: Around 125,785 new cases in year 2013-14 of leprosy were detected in India as per WHO report on leprosy in September 2015 which accounts to approximately 62% of the total new cases. Anaesthetic foot caused by leprosy leads to uneven loading of foot leading to ulcer in approximately 20% of the cases. Much efforts have gone in identifying newer techniques to efficiently monitor the progress of ulcer healing. Current techniques followed in measuring the size of ulcers, have not been found to be so accurate but are still is followed by clinicians across the globe...
August 11, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29406291/why-do-wounds-itch
#15
Ethan Lerner
Everyone has experienced itch. It might simply be the nuisance of a mosquito bite or a transient itch on the scalp that is relieved by a simple scratch. For wounds such as venous ulcers, itch may be present but is usually mild. For some of the 40% of people with neuropathic itch or pain that can develop and persist following mastectomy, itch can be overwhelming, intractable, not widely appreciated by the medical community, and poorly responsive to current treatment regimens. Why are some wounds in some patients itchy whereas seemingly equivalent ones in the same or other patients not? Why is the sensation of itch present in the wound itself in some cases while in the surrounding skin in others? Why are burns so frequently associated with itch? How commonly do wounds itch? Detailed answers to these questions are lacking, but this area is beginning to be explored...
January 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29346148/vertical-profunda-artery-perforator-flap-for-plantar-foot-wound-closure-a-new-application
#16
Allyson R Alfonso, James L Mayo, Vishal K Sharma, Robert J Allen, Ernest S Chiu
BACKGROUND: Plantar foot reconstruction requires special consideration of both form and function. There are several fasciocutaneous flap options, each with indications and reservations. CASE STUDY: This case presents a new application of the vertical profunda artery perforator flap for definitive closure of a neuropathic foot ulcer in a young woman with spina bifida. The postoperative course was uneventful, and the flap survived completely. The surgical and donor sites were without wound recurrence at 5-month follow-up...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29344337/financial-burden-of-diabetic-foot-ulcers-to-world-a-progressive-topic-to-discuss-always
#17
REVIEW
Alok Raghav, Zeeshan Ahmad Khan, Rajendra Kumar Labala, Jamal Ahmad, Saba Noor, Brijesh Kumar Mishra
Diabetic foot complications are the most common occurring problems throughout the globe, resulting in devastating economic crises for the patients, families and society. Diabetic foot ulcers (DFUs) have a neuropathic origin with a progressive prevalence rate in developing countries compared with developed countries among diabetes mellitus patients. Diabetic patients that are of greatest risk of ulcers may easily be diagnosed with foot examination. Economic burden may be carefully examined. The budget costing must include both the clinical and social impact of the patients...
January 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29337168/aggressive-resection-of-congenital-lumbosacral-lipomas-in-adults-indications-techniques-and-outcomes-in-122-patients
#18
Shao Cong Bai, Ben Zhang Tao, Le Kai Wang, Xin Guang Yu, Bai Nan Xu, Ai Jia Shang
OBJECTIVE: The authors reviewed the treatment of adult patients with congenital intraspinal lipomas with total/near-total resection and discussed their preoperative characteristics, prognostic factors, and surgical outcomes. METHODS: Medical records of 122 adult patients with congenital lumbosacral lipomas undergoing total/near-total resection were systematically analyzed. The cohort was subdivided into 3 groups depending on symptom onset age: group 1 (≤5 years, n = 40), group 2 (>5 years but <18 years, n = 33), and group 3 (>18 years, n = 49)...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29273187/distal-syme-hallux-amputation-for-tip-of-toe-wounds-and-gangrene-complicated-by-osteomyelitis-of-the-distal-phalanx-surgical-technique-and-outcome-in-consecutive-cases
#19
Troy J Boffeli, Mark S Goss
Distal hallux gangrene and neuropathic ulceration associated with digit deformity frequently result in osteomyelitis of the distal phalanx. Ideal treatment would involve limited resection to preserve function. We describe our surgical technique and retrospective results for distal Syme hallux amputation with plantar flap closure. An institutional review board-approved review was conducted on cases performed over 8 years. A total of 15 consecutive patients (16 digits) with hallux soft tissue loss who had undergone distal Syme hallux amputation were included...
December 19, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29240741/a-retrospective-audit-of-the-characteristics-and-treatment-outcomes-in-patients-with-diabetes-related-charcot-neuropathic-osteoarthropathy
#20
Joanne Dixon, Joshua Coulter, Michele Garrett, Rick Cutfield
AIMS: To review the characteristics, management and outcomes one year after diagnosis in patients with diabetes related charcot neuropathic osteoarthropathy (CN) treated at the Diabetes Podiatry service, Waitemata District Health Board (WDHB) between 2000-2014. METHODS: Patients with diabetes and recorded diagnosis of CN were identified from the podiatry service records. Clinical details were retrospectively obtained from WDHB databases and patient medical records...
December 15, 2017: New Zealand Medical Journal
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