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Malignant ulcer

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https://www.readbyqxmd.com/read/29905579/a-case-of-alk-anaplastic-large-cell-lymphoma-with-aberrant-myeloperoxidase-expression-and-initial-cutaneous-presentation
#1
Alejandro A Gru, Patrick J Voorhess
Anaplastic large-cell lymphoma (ALCL) was first described in 1985 by Stein et al and is a clinically, morphologically, and immunophenotypically heterogeneous neoplasm characterized by ALK expression, rearrangement of the ALK gene, and most characteristically its occurrence in children. Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma. Systemic ALK+ ALCL represents 10%-15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease...
November 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29885367/ecthyma-gangrenosum-vulvar-ulcers-pseudomonas-and-pancytopenia-a-case-report-of-an-18-month-old-female
#2
Nicole Todd, Julia E Boucher, Mylène Bassal, Tania Dumont, Nathalie Fleming
BACKGROUND: An 18-month-old female presenting with severe vulvar ulcers and pancytopenia with investigations revealing P.aeruginosa bacteremia. CASE: Previously healthy 18-month-old female presented with 6 days of fevers, vulvar rash and ulcers. Vulvar cultures demonstrated S.aureus and P.aeruginosa. Bloodwork showed pancytopenia and P.aeruginosa bacteremia. She started broad spectrum antibiotics. Bone marrow aspirate revealed a hypocellular marrow with erythroid dysplasia...
June 6, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29873857/foamy-macrophages-on-cytosmear-the-approach-to-diagnosis
#3
Debasis Gochhait, Vidhyalakshmi Rangarajan, Hema Subramanian, Sajini Elizabeth Jacob, Neelaiah Siddaraju, Laxmisha Chandrasekhar
A 65 year old emaciated patient presented to the Fine needle aspiration cytology (FNAC) clinic with multiple subcutaneous nodules for 1 year. The painful nodules of variable size were scattered throughout the body with ulceration in some of them (Figure I). In addition to that, the patient had generalized lympadenopathy which raised a clinical differential diagnosis of hematolymphoid/metastatic malignancy or disseminated fungal infection. This article is protected by copyright. All rights reserved.
June 6, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29862096/gastric-glomus-tumor-an-uncommon-source-for-an-acute-upper-gi-bleed
#4
Douglas Morte, Jason Bingham, Vance Sohn
Background: Glomus tumors are uncommon mesenchymal neoplasms originating from modified smooth muscle cells in the glomus body. They are generally small, solitary lesions found in the distal extremities. Rarely, involvement in the abdominal viscera can occur. In such cases, hematemesis/melena and epigastric discomfort are the most common initial symptoms. Although gastric glomus tumors can demonstrate malignant behavior, criteria for identifying malignant potential have yet to be established...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29860931/gastrinoma-and-zollinger-ellison-syndrome-in-canids-a-literature-review-and-a-case-in-a-mexican-gray-wolf
#5
Jason D Struthers, Nick Robl, Valerie M Wong, Matti Kiupel
Gastrinoma, an infrequent diagnosis in middle-aged dogs, occurs with nonspecific gastrointestinal morbidity. Laboratory tests can yield a presumptive diagnosis, but definitive diagnosis depends on histopathology and immunohistochemistry. We describe a malignant pancreatic gastrinoma with lymph node metastases and corresponding Zollinger-Ellison syndrome in a Mexican gray wolf ( Canis lupus baileyi) and review this endocrine neoplasm in domestic dogs. A 12-y-old, captive, male Mexican gray wolf developed inappetence and weight loss...
June 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29851815/small-gastric-hyperplastic-polyp-with-acute-bleeding-as-an-unusual-presentation-of-malignancy-a-case-report
#6
Kyoung Sun Park, Seung-Woo Lee, Junguee Lee, Moon Sung Kim, Pyung Hwa Park, Sung Jin Moon, Sang-Bum Kang, Dong Soo Lee
RATIONALE: Gastric hyperplastic polyps are frequently found on upper gastrointestinal endoscopy and usually asymptomatic. PATIENTS CONCERNS: A 65-year-old man visited the emergency department due to melena. Emergency upper endoscopy revealed a semi-pedunculated polyp measuring 1.2 cm in diameter with blood oozing. We resected the polyp using snare polypectomy. Ulceration was noted on the polypectomy specimen and was thought to be a bleeding focus. DIAGNOSES: Histopathologic findings revealed hyperplastic polyp with focal well-differentiated adenocarcinoma in the ulcerated area and involvement of the lateral resection margin by carcinoma...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29849602/the-use-of-complementary-and-alternative-medicine-is-less-frequent-in-patients-with-inflammatory-bowel-disease-than-in-patients-with-other-chronic-gastrointestinal-disorders
#7
Anna Fábián, Mariann Rutka, Tamás Ferenci, Renáta Bor, Anita Bálint, Klaudia Farkas, Ágnes Milassin, Kata Szántó, Zsuzsanna Lénárt, Ferenc Nagy, Zoltán Szepes, Tamás Molnár
Background and Aims: Complementary and alternative medicine (CAM) is commonly used among patients with inflammatory bowel diseases (IBD), but evidence about its real-life use is limited. We aimed to assess and compare CAM use in outpatients with IBD and other gastrointestinal diseases. Materials and Methods: The use of herbs and botanicals, lifestyle modifications and mind/body therapies, patient satisfaction, and continuous use of conventional medicine were assessed with an anonymous questionnaire at a tertiary IBD unit in Hungary...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29849527/an-odd-very-early-marjolin-s-ulcer-after-minimal-hand-burn
#8
A A Mohammadi, A Foroutan, S Mohammadi, M H Anbardar
Marjolin's ulcer refers to any malignant transformation of chronic wounds. Different chronic wounds may be transformed into malignancies, although they usually have a latency period of between 25 to 40 years after the primary injury. We herein present an otherwise healthy man who developed squamous cell carcinoma (SCC) three weeks after burn injury. It is an interesting case because of this acute transformation into SCC, and may be considered as different to the usual presentation of Marjolin's ulcers.
September 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29843119/giant-siliconoma-mimicking-locally-advanced-breast-cancer-a-case-report-and-review-of-literature
#9
Bryce Carson, Steven Cox, Hishaam Ismael
INTRODUCTION: Silicone prosthetics are widely used for breast augmentation and reconstruction. These devices may extrude free silicone into surrounding tissue, stimulating a granulomatous foreign body reaction. The resulting mass can mimic breast cancer. PRESENTATION OF CASE: 71 year old female with a history of a ruptured silicone implant presents with an enlarging left breast mass. Exam demonstrated and ulcerated, fungating mass with active infection. CT scan demonstrated a 23 × 15 cm mass involving the breast and chest wall with axillary lymphadenopathy...
May 11, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29808333/-update-polyarteritis-nodosa
#10
Jan H Schirmer, Frank Moosig
Polyarteritis nodosa (PAN) is a necrotizing arteritis of medium-sized vessels, which is often fatal if untreated. It frequently affects the skin (nodules and ulcers), the peripheral nervous system (mononeuritis multiplex) and the visceral vessels (stenoses and microaneurysms). The complex diagnostic work-up requires discriminating PAN from infectious, malignant, drug-induced and other inflammatory conditions. It can be subclassified into further variants (idiopathic, associated with hepatitis B, associated with hereditary inflammatory diseases or isolated cutaneous disease)...
May 28, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29806286/-application-of-free-anterolateral-thigh-kiss-flap-in-repair-of-large-scalp-defect-after-malignant-tumor-resection
#11
Liang Zuo, Jianjun Yu, Xiao Zhou, Jie Dai, Hao Tian, Zhenfeng Shan, Jie Hu, Xing Chen, Honghan Wang, Xu Cai, Shuichao Gao
Objective: To investigate the effectiveness of free anterolateral thigh Kiss flap in repair of large scalp defect after malignant tumor resection. Methods: Between December 2012 and December 2016,18 patients with large scalp defect after malignant tumor resection were treated. There were 16 males and 2 females with an average age of 52.6 years (range, 43-62 years). There were 17 cases of squamous carcinoma and 1 case of dermatofibrilsarcoma protuberan. The size of scalp defect ranged from 15 cm×10 cm to 17 cm×12 cm after resection of tumors...
March 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29795991/gastrointestinal-lesions-in-african-american-patients-with-iron-deficiency-anemia
#12
Hassan Brim, Anahita Shahnazi, Mehdi Nouraie, Dilhana Badurdeen, Adeyinka O Laiyemo, Tahmineh Haidary, Ali Afsari, Hassan Ashktorab
Background: Iron deficiency anemia (IDA) is a frequent disorder that is associated with many serious diseases. However, the findings of an evaluation of IDA-associated gastrointestinal disorders are lacking among African American patients. Aim: To determine the most prevalent gastrointestinal lesions among African American patients with IDA especially in young men. Methods: We reviewed medical records (n = 422) of patients referred for evaluation of IDA from 2008 to 2012...
2018: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/29790307/necrotising-sialometaplasia-a-diagnostic-perplexity-an-innocent-entity-to-malignant-masquerade
#13
Neeti Swarup, Meghanand T Nayak, Zoya Chowdhary, S Chandarani
Necrotising Sialometaplasia is a benign self limiting reactive condition of major and minor salivary glands, which can arouse suspicion for malignancy, clinically and histopathologically. Here, we report a case of 38-year-old female with a painful ulcer on the palate. The case enlightens the importance of clinicopathologic correlation and diligent follow up in diagnosis and management of the case.
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#14
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780262/high-mortality-due-to-cutaneous-melanoma-in-norway-a-study-of-prognostic-factors-in-a-nationwide-cancer-registry
#15
Trude Eid Robsahm, Per Helsing, Yngvar Nilssen, Linda Vos, Syed Mohammad H Rizvi, Lars A Akslen, Marit B Veierød
Purpose: The purpose of this study was to examine why Norway has the highest rate of mortality due to cutaneous melanoma (CM) in Europe. The Norwegian Malignant Melanoma Registry (NMMR) enables the study of clinical and histopathological characteristics of patients who die due to CM. Results: The NMMR and the Norwegian Cause of Death Registry provided data on the clinical and histopathological factors as well as the date and cause of death, through June 2015 for all first invasive CMs diagnosed in 2008-2012 (n=8087)...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29774226/metastatic-gastric-signet-ring-cell-carcinoma-mimicking-crohn-s-disease
#16
Michael W Winter, Amr Dokmak, Zachary Marnoy, Shweta Sinagare, Alexander N Levy
Signet-ring cell carcinoma (SRCC) is an adenocarcinoma characterized by mucin-producing cells and most commonly arises in the stomach. Colonic SRCC can share features of colitis, including long segments of concentric bowel wall thickening and ulcerated mucosa with regions of sparing. We describe a rare case of metastatic gastric SRCC mimicking Crohn's disease. Our patient underwent 2 colonoscopies, and biopsies revealed chronic active inflammation with no evidence of malignancy. The diagnosis of SRCC was only made after colectomy was performed for recurrent bowel obstruction...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29766398/hepatosplenic-t-cell-lymphoma-a-unifying-entity-in-a-patient-with-hemolytic-anemia-massive-splenomegaly-and-liver-dysfunction
#17
Marianna Mavilia, Agnes McAuliffe, Safina Hafeez, Haleh Vaziri
Hepatosplenic T cell lymphoma (HSTCL) is a rare subtype of peripheral non-Hodgkin lymphoma, of which 20% of cases are associated with chronic immunosuppression. It often occurs in patients with inflammatory bowel disease treated with immunomodulating medications such a thiopurines or TNF-alpha inhibitors. Cytopenias are commonly seen but autoimmune hemolytic anemia (AIHA) is rare. Here we present a young male with longstanding ulcerative colitis on chronic azathioprine, exhibiting several rare features of HSTCL...
May 15, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29765947/leser-tr%C3%A3-lat-syndrome-in-a-male-with-breast-carcinoma-and-eyelid-basal-cell-carcinoma
#18
Rajiv Garg, Siddharth Madan, Pragya Prakash, Ram Chander, Monisha Choudhary
Purpose: Leser-Trélat syndrome consists of appearance of a solid tumor-like carcinoma breast, colon, or stomach following eruption of multiple seborrheic keratoses (SK) of the skin. We present an unusual and possibly the first case report of Leser-Trélat syndrome in a male patient with a history of mastectomy for breast carcinoma who presented to us with a second malignancy in the form of basal cell carcinoma (BCC) of the lower eyelid. Procedure: A 75-year-old male presented in 2014 with a history of modified radical mastectomy for infiltrating ductal carcinoma of the left breast which was performed 11 years prior to the day of presentation...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29758191/an-atypical-infection-of-esophagus-mimicking-malignancy
#19
Ssu-Han Wang, Cheng-Kuan Lin, Yu-Chen Chang, Tzong-Hsi Lee, Chen-Shuan Chung
A 49-year-old man, who was an outdoor builder, had habitual consumption of cigarette, alcohol, and betel nut. He had dysphagia and hoarseness, accompanied with a weight loss of about 5 to 6 kg within 6 months. His esophagogastroduodenoscopy (EGD) (GIF-Q260, Olympus Medical Systems, Tokyo, Japan) demonstrated numerous granular lesions with some erosions and ulcers, mainly distributed at the middle to lower esophagus as seen by white-light imaging.
May 11, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29755852/high-frequency-generator-in-wound-healing-of-marjolin-s-ulcer-after-carcinoma-resection
#20
Pascale Mutti Tacani, Rogério Eduardo Tacani, Aline Fernanda Perez Machado, Débora Montezello, João Carlos Guedes Sampaio Góes, Angela Gonçalves Marx, Richard Eloin Liebano
Marjolin's ulcers (MU) are skin malignancies that form over burn injuries. These very aggressive ulcers can result in functional and wound healing impairment, and require a well thought out treatment plan. Physiotherapy offers resources to help promote recovery of these patients, as described in this case report, in which the patient with a history of burn in the lower limbs evolved to malignancy 32 years later. This patient underwent tumor resection of the left foot, with recurrence and lymphadenectomy . Physical therapy included the application of high-frequency generator (HFG) for wound healing and exercises for functional recovery...
May 1, 2018: Advances in Wound Care
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