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https://www.readbyqxmd.com/read/29626802/laparoscopic-excision-of-a-retroperitoneal-completely-isolated-enteric-duplication-cyst-in-an-adult-male-a-case-report-and-review-of-literature
#1
Naoya Sasaki, Miru Okamura, Satoshi Kanto, Kentaro Tatsumi, Seiichi Yasuda, Atsushi Kawabe
INTRODUCTION: Duplication cysts are very rare congenital malformations in adults. They are lined by gastrointestinal mucosa, connect to the digestive tract, and share smooth muscular layers and a common blood supply. In rare cases, duplication cysts are completely isolated from the digestive tract and have a proper blood supply. Completely isolated duplication cysts in the retroperitoneum are unusual so it is hard to diagnose them without a surgical resection. PRESENTATION OF CASE: A 19-year-old male presented at our emergency department with sharp abdominal pain...
March 28, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29617680/the-role-of-crush-cytology-in-the-diagnosis-of-large-intestine-lesions-with-correlation-on-histopathology
#2
Chaithra Gv, Debarshi Saha, Richa Yadav, Deepa S Adiga, Flore D Lobo, Apurv Ghosh, Jyoti Kini
OBJECTIVE: To study the efficacy of colonoscopic crush cytology as a convenient and near-accurate method to evaluate colonic neoplasms. STUDY DESIGN: Retrospective and cross-sectional. The original cytologic diagnoses were correlated with a histology report on 100 cases sent to the cytology laboratory over 2 years. RESULTS: Of the 100 cases, 25 were nonmalignant. Of the 75 malignant lesions, 72 could be identified as positive for malignancy on cytology...
April 4, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29607436/autoimmune-hemolytic-anemia-associated-with-infliximab-infusion-in-ulcerative-colitis
#3
Fazia A Mir, Alhareth Al Juboori, Jack D Bragg, Veysel Tahan
Infliximab is a monoclonal antibody that antagonizes the activity of tumor necrosis factor alpha to induce and maintain remission in patients with inflammatory bowel disease. Adverse effects associated with Infliximab infusions include infusion reactions, risk of infections, development of hematological malignancies, and pancytopenia. Autoimmune hemolytic anemia has rarely been reported in ulcerative colitis. Herein we report a case of drug-induced hemolytic anemia after infliximab infusion for treating ulcerative colitis...
2018: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/29606936/vedolizumab-as-a-potential-culprit-in-the-development-of-ovarian-teratoma
#4
Judy A Trieu, Mohammad Bilal, Gurinder Luthra
Vedolizumab is a new humanized monoclonal antibody that has been reserved for those with moderate-to-severe Crohn's disease and ulcerative colitis who have failed immunomodulator and TNF-α antagonist therapy, and for those who have an increased risk for developing progressive multifocal leukoencephalopathy. Because it targets gastrointestinal tract-specific lymphocytes, meta-analyses and integrated studies have shown that vedolizumab causes fewer extraintestinal adverse effects, such as opportunistic infections and malignancies, compared with anti-TNF therapies...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29602460/preoperative-gastric-lavage-in-gastric-cancer-patients-undergoing-surgical-endoscopic-or-minimally-invasive-treatment-an-oncological-measure-preventing-peritoneal-spillage-of-intragastric-cancer-cells-and-development-of-related-metastases
#5
Edoardo Virgilio, Genoveffa Balducci, Paolo Mercantini, Enrico Giarnieri, Maria Rosaria Giovagnoli, Monica Montagnini, Antonella Proietti, Rosaria D'Urso, Marco Cavallini
In addition to classical metastatic pathways, recently gastric cancer was described having an alternative route called "endoluminal exfoliation". Provisional analyses demonstrated, in fact, this kind of shedding is associated with several clinico-pathological features indicative of aggressive behavior and resulted to be an independent prognostic factor entailing poor prognosis. Compared with non-sowing counterparts, in fact, patients affected with exfoliating early and advanced gastric carcinomas met with shorter overall survival, disease free survival, progression free survival and time to tumor progression...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29600228/incidental-gallbladder-carcinoma-utility-of-histopathological-evaluation-of-routine-cholecystectomy-specimens
#6
Vidya Jha, Preeti Sharma, K Ashish Mandal
Background: Incidental gallbladder carcinoma (IGBC) is rare cancer diagnosed during or after cholecystectomy done for benign gallbladder disease. The concern whether routine histopathological examination is needed for all cholecystectomy specimens still remains debatable. Materials and Methods: Twenty patients diagnosed with IGBC over a period of 2 years were retrospectively reviewed. Clinical details including clinical presentation, preoperative ultrasound (USG) findings, and macroscopic features were retrieved...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29596683/marjolin-s-ulcer-arising-in-a-burn-scar
#7
Andrea Sisti, Edoardo Pica Alfieri, Roberto Cuomo, Luca Grimaldi, Cesare Brandi, Giuseppe Nisi
Marjolin's ulcer is an aggressive disease arising in chronic wounds and cutaneous scars. Corbo et al define Marjolin's ulcer an often overlooked or misdiagnosed tumor. We report a case of Marjolin's ulcer arose in a burn scar of a 51-year-old man who sustained a burn in childhood. A punch biopsy showed squamous cell carcinoma. The lesion was surgically removed with wide excision. The loss of substance was covered with a partial-thickness skin graft, harvested from the left thigh with dermatome. Histological examination confirmed a well-differentiated squamous cell carcinoma...
January 18, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29595104/association-of-metronidazole-with-cancer-a-potential-risk-factor-or-inconsistent-deductions
#8
Muhammad Adil, Waheed Iqbal, Fazal Adnan, Shabnam Wazir, Imran Khan, Mohammad Umar Khayam, Mohammad Amjad Kamal, Shafiq Ahmad, Jawad Ahmad, Ishaq N Khan
Metronidazole is a synthetic derivative of nitroimidazole that has been widely used for the treatment of several bacterial and protozoal parasitic infections including trichomoniasis, amoebiasis, giardiasis, liver abscess, acute ulcerative gingivitis, syphilis and tropical phagedena. In addition to its toxicity in the gastrointestinal tract and central/peripheral nervous system, metronidazole has been reported to cause mucosal imbalance by affecting the expression of mucin (Muc2 gene), which is responsible to form an insoluble mucous barrier that protects the gut lumen from microbial colonization...
March 29, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29570860/undifferentiated-type-component-mixed-with-differentiated-type-early-gastric-cancer-is-a-significant-risk-factor-for-endoscopic-non-curative-resection
#9
Yusuke Horiuchi, Junko Fujisaki, Noriko Yamamoto, Naoki Ishizuka, Masami Omae, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
OBJECTIVES: Previous studies of surgical specimens have found that the presence of mixed histological components in differentiated-type early gastric cancer (EGCs) is a risk factor for lymph node metastasis and indicates more malignancy. Because there have been no reports on endoscopic treatment of it, we examined the endoscopic curative resection in relation to differentiated-type-predominant mixed-type (MT). METHODS: This was a single-center, retrospective study...
March 23, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29570169/telomerase-reverse-transcriptase-promoter-mutations-and-solar-elastosis-in-cutaneous-melanoma
#10
Johanne Lade-Keller, Sakineh Yuusufi, Rikke Riber-Hansen, Torben Steiniche, Magnus Stougaard
The aims of this study were to assess the prognostic potential of solar elastosis grading and telomerase reverse transcriptase (TERT) promoter mutations (TERTp) in melanoma and to evaluate whether an association between solar elastosis and TERTp exists. Solar elastosis in the dermis was evaluated in hematoxylin and eosin-stained whole slides from 486 malignant melanomas. Pyrosequencing was used to detect TERTp in 189 samples. There was no association between solar elastosis and TERTp (P=0.3). Severe elastosis was associated with older age (P<0...
March 21, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29566932/the-status-of-the-seborrheic-keratosis
#11
Ayse Serap Karadag, Lawrence Charles Parish
Seborrheic keratosis (SK), whose appearance is generally a small roundish reddish to brownish scaling lesion ranging in size from a few mm to many mm, may have a single presentation or be one of many such lesions. Because it is a commonly encountered lesion on the face, trunk, or extemities and is readily recognized clinically, it is infrequently biopsied. When the lesion has an unusual pattern or has become irritated, it may rarely mimic a malignancy,Most patients ignore such common age spots; however, others may have concern about their appearence, in which case the SKs have been surgicaly excised...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29566924/genital-diseases-in-the-mature-man
#12
Richard E Watchorn, Christopher B Bunker
Elderly men are at higher risk of developing genital dermatologic problems, including inflammatory and neoplastic conditions due to age-related physiologic changes, immunosenescence, comorbidities, and iatrogenesis. Clinical manifestations of genital dermatoses in men are varied and may include itching, pain, redness, dermatitis, lumps, and ulcers. Even when asymptomatic, the psychologic impact may be significant. Sexual or urinary dysfunction may complicate genital dermatoses. Early and accurate diagnosis is essential to reduce morbidity and mortality from premalignant and malignant conditions and also to prevent sexual dysfunction and unnecessary anxiety in the case of benign entities...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29566370/dermoscopic-features-of-basal-cell-carcinoma-on-the-lower-limbs-a-chameleon
#13
Mara Lombardi, Riccardo Pampena, Stefania Borsari, Caterina Bombonato, Elisa Benati, Giovanni Pellacani, Caterina Longo
BACKGROUND: Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions. OBJECTIVE: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benign- or malignant-looking appearance...
March 22, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29563742/papillary-adenocarcinoma-in-a-gastric-duplication-cyst
#14
Sonali Sethi, Satyajit Godhi, Sunil Kumar Puri
Gastric duplication cysts are rare and mostly present in the first year of life. In adulthood presentation is in the form of obstruction, ulceration, bleeding, fistulization etc. Malignancy is extremely rare with only 12 cases reported to date. We came across a gastric duplication cyst with papillary adenocarcinoma in a 63 year old man. He underwent cyst excision with radical subtotal gastrectomy. The awareness of such a condition made it possible for us to have a suspicion of malignancy preoperatively based on imaging and thus a radical surgery was performed...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29560650/an-unusual-case-of-hamartomatous-polyposis-with-malignancy-complication-in-a-patient-with-ulcerative-colitis-treated-with-golimumab
#15
A Al Khoury, C-Y Chao, S Camilleri-Broet, T Bessissow
We report an unusual case of hamartomatous polyposis with malignant complications in a patient with ulcerative colitis on golimumab and previous thiopurine therapy. This patient was evaluated for iron deficiency anemia and underwent hemicolectomy for extensive right-side predominant inflammatory pseudopolyps. Anemia persisted post-colectomy and subsequent gastroscopy showed a fungating polypoid lesion along with numerous carpet-like strawberry appearing polyps in the stomach extending from the gastro-esophageal junction to the distal part of the antrum, necessitating a gastrectomy...
October 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29556388/late-duodenal-metastasis-from-renal-cell-carcinoma-with-newly-developed-malignant-lymphoma-a-case-report
#16
Makoto Saito, Hajime Senjo, Minoru Kanaya, Koh Izumiyama, Akio Mori, Masanori Tanaka, Masanobu Morioka, Kencho Miyashita, Yusuke Ishida
Duodenal metastasis from renal cell carcinoma (RCC) is rare. The current case report presents a very rare case of late duodenal metastasis from RCC with newly developed malignant lymphoma (diffuse large B-cell lymphoma: DLBCL) at the same time. A 64-year-old man with systemic lymph nodes swelling who had undergone left nephrectomy for RCC 25 years previously, was admitted to the present hospital. Inguinal lymph node biopsy was performed, leading to a diagnosis of DLBCL. fluorine-18-fluorodeoxy-glucose (18 F-FDG)-positron emission tomography (PET)/computed tomography (CT) revealed multiple lymph nodes, spleen, and ileocecal lesions...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29552352/cutaneous-non-epitheliotropic-t-cell-lymphoma-associated-with-a-fracture-site-in-a-cat
#17
Selvi Jegatheeson, Julie Wayne, Laura K Brockley
Case summary: A 7-year-old male neutered domestic shorthair cat presented for investigation of a swelling over the right forelimb. Radiographs of the right forelimb revealed significant lysis and soft tissue swelling surrounding a previously implanted surgical plate, used to repair a fracture of the distal radius 5 years prior. The implant was removed, and a biopsy was collected. Histopathological analysis and immunohistochemistry diagnosed a non-epitheliotropic T-cell cutaneous lymphoma...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29546569/a-case-of-duodenal-malignant-lymphoma-presenting-as-acute-pancreatitis-systemic-lupus-erythematosus-and-immunosuppressive-therapy-as-risk-factors
#18
Reiko Yamada, Takashi Sakuno, Hiroyuki Inoue, Hiroshi Miura, Toshifumi Takeuchi, Yasunori Shiono, Hiroaki Okuse, Misaki Nakamura, Masaki Katsurahara, Yasuhiko Hamada, Kyosuke Tanaka, Noriyuki Horiki, Yoshiyuki Takei
A 49-year-old man was admitted to our hospital with pancreatitis. He was diagnosed with systemic lupus erythematosus at 34 years of age and was being treated with oral tacrolimus (3 mg/day) and predonine (10 mg/day) for the past 15 months. The computed tomography (CT) scan showed the mass lesion had invaded the pancreatic head via thickening of the duodenal wall. Upper gastrointestinal endoscopy showed the all-round ulcerative lesion from the superior duodenal angle to the descending portion. Histological examination confirmed the diagnosis of diffuse large B cell lymphoma (DLBCL)...
March 15, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29543326/non-invasive-diagnostic-tests-for-helicobacter-pylori-infection
#19
REVIEW
Lawrence Mj Best, Yemisi Takwoingi, Sulman Siddique, Abiram Selladurai, Akash Gandhi, Benjamin Low, Mohammad Yaghoobi, Kurinchi Selvan Gurusamy
BACKGROUND: Helicobacter pylori (H pylori) infection has been implicated in a number of malignancies and non-malignant conditions including peptic ulcers, non-ulcer dyspepsia, recurrent peptic ulcer bleeding, unexplained iron deficiency anaemia, idiopathic thrombocytopaenia purpura, and colorectal adenomas. The confirmatory diagnosis of H pylori is by endoscopic biopsy, followed by histopathological examination using haemotoxylin and eosin (H & E) stain or special stains such as Giemsa stain and Warthin-Starry stain...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29534593/neurotropism-as-a-prognostic-factor-in-cutaneous-melanoma-patients
#20
F Tas, K Erturk
Neurotropism is a feature that is encountered rarely in melanoma and is considered to be associated with increased risk of local recurrence. However, its prognostic significance still remains controversial. The objective of this study was to deter- mine the clinical significance of neurotropism in cutaneous melanoma patients. A total of 519 cutaneous melanoma patients were enrolled into this study and their data were analyzed in a retrospective fashion. The melanomas without neurotro- pism (n=496; 95.6%) were larger in number than those with neurotropism (n=23; 4...
2018: Neoplasma
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