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https://www.readbyqxmd.com/read/28654822/gender-and-the-structure-of-self-rated-health-across-the-adult-life-span
#1
Anna Zajacova, Snehalata Huzurbazar, Megan Todd
Despite the widespread use of self-rated health (SRH) in population health studies, the meaning of this holistic health judgment remains an open question. Gender differences in health, an issue of utmost importance in population research and policy, are often measured with SRH; the comparisons could be biased if men and women differ in how they form their health judgment. The aim of this study is to examine whether men and women differ in how health inputs predict their health rating across the adult life span...
June 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28654387/phosphatidylserine-targeted-nanotheranostics-for-brain-tumor-imaging-and-therapeutic-potential
#2
Lulu Wang, Amyn A Habib, Akiva Mintz, King C Li, Dawen Zhao
Phosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal cells. However, this PS asymmetry is found disruptive in many tumor vascular endothelial cells. We discuss the underlying mechanisms for PS asymmetry maintenance in normal cells and its loss in tumor cells. The specificity of PS exposure in tumor vasculature but not normal blood vessels may establish it a useful biomarker for cancer molecular imaging. Indeed, utilizing PS-targeting antibodies, multiple imaging probes have been developed and multimodal imaging data have shown their high tumor-selective targeting in various cancers...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28653283/beneficial-effects-of-ketogenic-diets-for-cancer-patients-a-realist-review-with-focus-on-evidence-and-confirmation
#3
REVIEW
Rainer J Klement
Ketogenic diets (KDs) have gained popularity among patients and researchers alike due to their putative anti-tumor mechanisms. However, the question remains which conclusions can be drawn from the available human data thus far concerning the safety and efficacy of KDs for cancer patients. A realist review utilizing a matrix analytical approach was conducted according to the RAMESES publication standards. All available human studies were systematically analyzed and supplemented with results from animal studies...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28653259/a-medication-assessment-tool-to-evaluate-prescribers-adherence-to-evidence-based-guidelines-in-bipolar-disorder
#4
Dalal M Al-Taweel, Mohammad Alsuwaidan
Background The goal of evidence-based clinical practice has led to an increased interest in the development of tools to measure adherence to national guidelines in different diseases. This aids in detecting and measuring inappropriate prescribing to specific patient groups by using quality standards extracted from evidence-based guidelines, and ultimately provide the basis of consistent standardized prescribing. Objective To design and validate a medication assessment tool to assess prescribers' adherence to international guideline recommendations in the management of bipolar disorder (MATBD)...
June 26, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28653150/linkage-map-construction-and-qtl-analysis-for-internal-heat-necrosis-in-autotetraploid-potato
#5
Mitchell J Schumann, Zhao-Bang Zeng, Mark E Clough, G Craig Yencho
A tetraploid potato population was mapped for internal heat necrosis (IHN) using the Infinium (®) 8303 potato SNP array, and QTL for IHN were identified on chromosomes 1, 5, 9 and 12 that explained 28.21% of the variation for incidence and 25.3% of the variation for severity. This research represents a significant step forward in our understanding of IHN, and sets the stage for future research focused on testing the utility of these markers in additional breeding populations. Internal heat necrosis (IHN) is a significant non-pathogenic disorder of potato tubers and previous studies have identified AFLP markers linked to IHN susceptibility in the tetraploid, B2721 potato mapping population...
June 26, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28653117/treating-eating-disorders-at-higher-levels-of-care-overview-and-challenges
#6
REVIEW
Leslie K Anderson, Erin E Reilly, Laura Berner, Christina E Wierenga, Michelle D Jones, Tiffany A Brown, Walter H Kaye, Anne Cusack
Higher levels of care (HLC)-including inpatient hospitalization, residential treatment, partial hospitalization, and intensive outpatient treatment-are frequently utilized within routine care for eating disorders. Despite widespread use, there is limited research evaluating the efficacy of HLC, as well as clinical issues related to care in these settings. This review describes the different levels of care for eating disorders and briefly reviews the most up-to-date guidelines and research regarding how to choose a level of care...
August 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28652942/time-to-cash-in-on-positive-interactions-for-coral-restoration
#7
Elizabeth C Shaver, Brian R Silliman
Coral reefs are among the most biodiverse and productive ecosystems on Earth, and provide critical ecosystem services such as protein provisioning, coastal protection, and tourism revenue. Despite these benefits, coral reefs have been declining precipitously across the globe due to human impacts and climate change. Recent efforts to combat these declines are increasingly turning to restoration to help reseed corals and speed-up recovery processes. Coastal restoration theory and practice has historically favored transplanting designs that reduce potentially harmful negative species interactions, such as competition between transplants...
2017: PeerJ
https://www.readbyqxmd.com/read/28652857/fiber-optic-force-sensors-for-mri-guided-interventions-and-rehabilitation-a-review
#8
Hao Su, Iulian I Iordachita, Junichi Tokuda, Nobuhiko Hata, Xuan Liu, Reza Seifabadi, Sheng Xu, Bradford Wood, Gregory S Fischer
Magnetic Resonance Imaging (MRI) provides both anatomical imaging with excellent soft tissue contrast and functional MRI imaging (fMRI) of physiological parameters. The last two decades have witnessed the manifestation of increased interest in MRI-guided minimally invasive intervention procedures and fMRI for rehabilitation and neuroscience research. Accompanying the aspiration to utilize MRI to provide imaging feedback during interventions and brain activity for neuroscience study, there is an accumulated effort to utilize force sensors compatible with the MRI environment to meet the growing demand of these procedures, with the goal of enhanced interventional safety and accuracy, improved efficacy and rehabilitation outcome...
April 1, 2017: IEEE Sensors Journal
https://www.readbyqxmd.com/read/28652226/a-hybrid-web-based-and-in-person-self-management-intervention-to-prevent-acute-to-chronic-pain-transition-after-major-lower-extremity-trauma-ipact-e-trauma-protocol-for-a-pilot-single-blind-randomized-controlled-trial
#9
Mélanie Bérubé, Céline Gélinas, Géraldine Martorella, José Côté, Nancy Feeley, George-Yves Laflamme, Dominique Rouleau, Manon Choinière
BACKGROUND: Acute pain frequently transitions to chronic pain after major lower extremity trauma (ET). Several modifiable psychological risk and protective factors have been found to contribute to, or prevent, chronic pain development. Some empirical evidence has shown that interventions, including cognitive and behavioral strategies that promote pain self-management, could prevent chronic pain. However, the efficacy of such interventions has never been demonstrated in ET patients. We have designed a self-management intervention to prevent acute to chronic pain transition after major lower extremity trauma (iPACT-E-Trauma)...
June 26, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28652205/opioid-analgesics-administered-for-pain-on-the-inpatient-pediatric-setting
#10
Gary A Walco, Nancy Gove, Jennifer Phillips, Steven J Weisman
This study aimed to describe utilization of opioid medications among infants, children, and adolescents on the inpatient setting. These data are needed to guide clinical trials and improve research methodologies, as well as to inform more about possible sources of opioid misuse in the United States. A retrospective chart review was conducted covering a span of one year, with a special focus on the prescription of opioids for long-term treatment of chronic pain. Opioid medications were prescribed for less than 5 days in the overwhelming majority (75%) of patients...
June 23, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28652166/multilingual-self-management-resources-for-prostate-cancer-survivors-and-their-partners-results-of-a-long-term-academic-state-health-department-partnership-to-promote-survivorship-care
#11
Ted A Skolarus, Jennifer A Ragnoni, Carol Garlinghouse, Ann Schafenacker, Debbie Webster, Polly Hager, Daniela Wittmann, Laurel Northouse
INTRODUCTION: There is increasing need for innovative, sustainable ways to provide evidence-based self-management information and supportive care for prostate cancer survivors and their partners. For these reasons, we describe how an academic-public partnership facilitated the broad dissemination of evidence-based, multilingual survivorship educational materials via a state-managed prostate cancer website. METHODS: We outline the steps of an academic-public partnership leading to dissemination of online, survivorship materials as a resource for prostate cancer survivors and their partners...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28652069/facilitating-tough-conversations-using-an-innovative-simulation-primed-qualitative-inquiry-in-pediatric-research
#12
REVIEW
Ambrose H Wong, Gunjan K Tiyyagura, James M Dodington, Bonnie Hawkins, Denise Hersey, Marc A Auerbach
Deep exploration of a complex healthcare issue in pediatrics may be hindered by the sensitive or infrequent nature of a particular topic in pediatrics. Healthcare simulation builds on constructivist theories to guide individuals through an experiential cycle of action, self-reflection, and open discussion, but has traditionally been applied to the educational domain in health sciences. Leveraging the emotional activation of a simulated experience, investigators can prime participants to engage in open dialog for the purposes of qualitative research...
June 23, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28651900/potential-clinical-applications-of-placental-stem-cells-for-use-in-fetal-therapy-of-birth-defects
#13
Melissa Vanover, Aijun Wang, Diana Farmer
Placental stem cells are of growing interest for a variety of clinical applications due to their multipotency and ready availability from otherwise frequently discarded biomaterial. Stem cells derived from the placenta have been investigated in a number of disease processes, including wound healing, ischemic heart disease, autoimmune disorders, and chronic lung or liver injury. Fetal intervention for structural congenital defects, such as spina bifida, has rapidly progressed as a field due to advances in maternal-fetal medicine and improving surgical techniques...
May 18, 2017: Placenta
https://www.readbyqxmd.com/read/28651803/clinical-outcomes-research-in-gynecologic-oncology
#14
Alexander Melamed, J Alejandro Rauh-Hain, John O Schorge
Clinical outcomes research seeks to understand the real-world manifestations of clinical care. In particular, outcomes research seeks to reveal the effects of pharmaceutical, procedural, and structural aspects of healthcare on patient outcomes, including mortality, disease control, toxicity, cost, and quality of life. Although outcomes research can utilize interventional study designs, insightful use of observational data is a defining feature of this field. Many questions in gynecologic oncology are not amenable to investigation in randomized clinical trials due to cost, feasibility, or ethical concerns...
June 23, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28651634/data-and-expert-driven-rule-induction-and-filtering-framework-for-functional-interpretation-and-description-of-gene-sets
#15
Aleksandra Gruca, Marek Sikora
BACKGROUND: High-throughput methods in molecular biology provided researchers with abundance of experimental data that need to be interpreted in order to understand the experimental results. Manual methods of functional gene/protein group interpretation are expensive and time-consuming; therefore, there is a need to develop new efficient data mining methods and bioinformatics tools that could support the expert in the process of functional analysis of experimental results. RESULTS: In this study, we propose a comprehensive framework for the induction of logical rules in the form of combinations of Gene Ontology (GO) terms for functional interpretation of gene sets...
June 26, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28651613/an-audience-research-study-to-disseminate-evidence-about-comprehensive-state-mental-health-parity-legislation-to-us-state-policymakers-protocol
#16
Jonathan Purtle, Félice Lê-Scherban, Paul Shattuck, Enola K Proctor, Ross C Brownson
BACKGROUND: A large proportion of the US population has limited access to mental health treatments because insurance providers limit the utilization of mental health services in ways that are more restrictive than for physical health services. Comprehensive state mental health parity legislation (C-SMHPL) is an evidence-based policy intervention that enhances mental health insurance coverage and improves access to care. Implementation of C-SMHPL, however, is limited. State policymakers have the exclusive authority to implement C-SMHPL, but sparse guidance exists to inform the design of strategies to disseminate evidence about C-SMHPL, and more broadly, evidence-based treatments and mental illness, to this audience...
June 26, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28651135/a-model-biorefinery-for-avocado-persea-americana-mill-processing
#17
Javier A Dávila, Moshe Rosenberg, Eulogio Castro, Carlos A Cardona
This research investigated and evaluated a biorefinery for processing avocado Hass variety into microencapsulated phenolic compounds extract, ethanol, oil and xylitol. Avocado was first characterized for its potential valuable compounds; then, the techno-economic and environmental aspects of the biorefinery were developed and finally the total production costs and potential environmental impact of the proposed biorefinery were investigated. Four scenarios of the biorefinery were evaluated with different extent of mass and energy integration as well as the incorporation of a cogeneration system...
June 15, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28650980/changes-in-transcript-levels-of-starch-hydrolysis-genes-and-raising-citric-acid-production-via-carbon-ion-irradiation-mutagenesis-of-aspergillus-niger
#18
Wei Hu, Wenjian Li, Hao Chen, Jing Liu, Shuyang Wang, Jihong Chen
The filamentous ascomycete Aspergillus niger is well known for its ability to accumulate citric acid for the hydrolysis of starchy materials. To improve citric acid productivity, heavy ion beam mutagenesis was utilized to produce mutant A.niger strains with enhanced production of citric acid in this work. It was demonstrated that a mutant HW2 with high concentration of citric acid was isolated after carbon ion irradiation with the energy of 80Mev/μ, which was obvious increase higher than the original strain from liquefied corn starch as a feedstock...
2017: PloS One
https://www.readbyqxmd.com/read/28650799/learning-the-personalized-intransitive-preferences-of-images
#19
Jun Chen, Chaokun Wang, Jianmin Wang, Xiang Ying, Xuecheng Wang
Most of the previous studies on the user preferences assume that there is a personal transitive preference ranking of the consumable media like images. For example, the transitivity of preferences is one of the most important assumptions in the recommender system research. However, the intransitive relations have also been widely observed, such as the win/loss relations in online video games, in sport matches, and even in rock-paper-scissors games. It is also found that different subjects demonstrate the personalized intransitive preferences in the pairwise comparisons between the applicants for college admission...
September 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28650559/the-antibacterial-activity-and-modes-of-li-f-type-antimicrobial-peptides-against-bacillus-cereus-in-vitro
#20
Jinzhi Han, Shengming Zhao, Zhi Ma, Ling Gao, Hongxia Liu, Umair Muhammad, Zhaoxin Lu, Fengxia Lv, Xiaomei Bie
AIMS: LI-Fs are a family of highly potent cyclic lipodepsipeptide antibiotics with a broad antimicrobial spectrum (Gram-positive bacteria and fungi). In this study, LI-F type antimicrobial peptides (AMP-jsa9) composing of LI-F03a, LI-F03b, LI-F04a, LI-F04b, and LI-F05b were isolated from Paenibacillus polymyxa JSA-9. To better understand the antimicrobial mechanism of AMP-jsa9, the potency and action(s) of AMP-jsa9 against B. cereus were examined. METHODS AND RESULTS: Flow cytometry, confocal laser microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM) observation, as well as determination of peptidoglycan and cell wall associated protein, and other methods were used...
June 26, 2017: Journal of Applied Microbiology
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