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https://www.readbyqxmd.com/read/27910804/sudden-cardiac-death-a-nationwide-cohort-study-among-the-young
#1
Bjarke Risgaard
Sudden cardiac death (SCD) is a tragic event affecting millions of individuals worldwide. Although several studies have investigated the epidemiology of SCD, these studies may have been affected by reporting and referral biases, which are reflected in the very different incidence rates and causes of deaths that have previously been reported. Among SCD victims aged < 36 years, inherited cardiac diseases are well known to play an important role. However, the extent to which inherited cardiac diseases also play a role in SCD victims aged < 50 years has not been completely described...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27852328/a-pilot-program-of-knowledge-translation-and-implementation-for-newborn-resuscitation-using-us-peace-corps-volunteers-in-rural-madagascar
#2
Kristin Close, Michele Karel, Michelle White
BACKGROUND: Prevention of adverse perinatal outcome using the Helping Babies Breathe (HBB) neonatal resuscitation algorithm can reduce perinatal mortality in low income settings. Mercy Ships is a non-governmental organisation providing free healthcare education in sub-Saharan Africa and in an attempt to reach more rural areas of Madagascar with our neonatal resuscitation training we designed a novel approach in collaboration with US Peace Corps Volunteers (PCV). PCVs work in rural areas and contribute to locally determined public health initiatives...
November 16, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27814620/mucopolysaccharidosis-vi-pathophysiology-diagnosis-and-treatment
#3
Paul Harmatz, Renee Shediac
Mucopolysaccharidosis VI (MPS VI), or Maroteaux-Lamy syndrome, is an autosomal recessive lysosomal storage disorder caused by deficient activity of the enzyme arylsulfatase B (ASB). Progressive accumulation of glycosaminoglycans (GAGs) in organs and tissues leads to the development of multisystem clinical manifestations. The presentation of MPS VI is genotypically and phenotypically diverse, with a large number of potential disease-causing mutations and a phenotypic spectrum ranging from very slowly to very rapidly progressing disease...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27786147/anticholinergic-medication-use-is-associated-with-globus-pharyngeus
#4
S Haft, R M Carey, D Farquhar, N Mirza
BACKGROUND: Globus pharyngeus has been linked to salivary hypofunction. We hypothesise that a considerable portion of the globus experienced by patients is due to a drying effect secondary to anticholinergic medication use; this study aimed to determine their association. METHODS: A cross-sectional study was conducted of 270 patients who presented to a laryngology practice over 6 months. Participants rated globus sensation on a 5-point severity scale, with those scoring 0 considered as controls (non-globus)...
October 27, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27774066/rhizoma-coptidis-a-potential-cardiovascular-protective-agent
#5
Hui-Li Tan, Kok-Gan Chan, Priyia Pusparajah, Acharaporn Duangjai, Surasak Saokaew, Tahir Mehmood Khan, Learn-Han Lee, Bey-Hing Goh
Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality in both the developed and developing world. Rhizoma coptidis (RC), known as Huang Lian in China, is the dried rhizome of medicinal plants from the family Ranunculaceae, such as Coptis chinensis Franch, C. deltoidea C.Y. Cheng et Hsiao, and C. teeta Wall which has been used by Chinese medicinal physicians for more than 2000 years. In China, RC is a common component in traditional medicines used to treat CVD associated problems including obesity, diabetes mellitus, hyperlipidemia, hyperglycemia and disorders of lipid metabolism...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27721966/human-split-thickness-skin-allograft-from-brain-dead-donors
#6
A Khodadadi, O Olang, A Makhllough, B Nozary Heshmati, F Azmoudeh Ardalan, S A Tavakoli
BACKGROUND: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers. OBJECTIVE: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbits. METHODS: After receiving negative serologic tests of BDDs, we prepared partial thickness skin grafts. They were then used in treating wounds of 5 rabbits in comparison with split-thickness skins taken from cardiac dead donors...
2016: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/27708179/understanding-and-discrimination-of-biofilms-of-clinically-relevant-microorganisms-using-surface-enhanced-raman-scattering
#7
Seda Keleştemur, Mustafa Çulha
Biofilm formation is a defense mechanism for microorganisms to survive under both natural and stress conditions. Clinically relevant microorganisms threaten patient health through biofilm formation on medical devices and implants. It is very important to identify biofilm formation in order to suppress their pathogenic activities in early stages. With the aim for better understanding biofilm formation and possibility of detection, in this study, biofilm formation of clinically important microorganisms, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Candida albicans are monitored with surface-enhanced Raman scattering (SERS)...
October 5, 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27694393/stable-isotope-dilution-hplc-electrospray-ionization-tandem-mass-spectrometry-method-for-quantifying-hydroxyurea-in-dried-blood-samples
#8
Anu Marahatta, Vandana Megaraj, Patrick T McGann, Russell E Ware, Kenneth D R Setchell
BACKGROUND: Sickle cell anemia (SCA) is a life-threatening blood disorder characterized by the presence of sickle-shaped erythrocytes. Hydroxyurea is currently the only US Food and Drug Administration-approved treatment and there is a need for a convenient method to monitor compliance and hydroxyurea concentrations, especially in pediatric SCA patients. METHODS: We describe a novel approach to the determination of hydroxyurea concentrations in dried whole blood collected on DMPK-C cards or volumetric absorptive microsampling (VAMS) devices...
December 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27671660/mitochondrial-dna-from-the-eradicated-european-plasmodium-vivax-and-p-falciparum-from-70-year-old-slides-from-the-ebro-delta-in-spain
#9
Pere Gelabert, Marcela Sandoval-Velasco, Iñigo Olalde, Rosa Fregel, Adrien Rieux, Raül Escosa, Carles Aranda, Krijn Paaijmans, Ivo Mueller, M Thomas P Gilbert, Carles Lalueza-Fox
Phylogenetic analysis of Plasmodium parasites has indicated that their modern-day distribution is a result of a series of human-mediated dispersals involving transport between Africa, Europe, America, and Asia. A major outstanding question is the phylogenetic affinity of the malaria causing parasites Plasmodium vivax and falciparum in historic southern Europe-where it was endemic until the mid-20th century, after which it was eradicated across the region. Resolving the identity of these parasites will be critical for answering several hypotheses on the malaria dispersal...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27649531/mechanistic-insights-into-the-antilithiatic-proteins-from-terminalia-arjuna-a-proteomic-approach-in-urolithiasis
#10
Amisha Mittal, Simran Tandon, Surender Kumar Singla, Chanderdeep Tandon
Kidney stone formation during hyperoxaluric condition is inherently dependent on the interaction between renal epithelial cells and calcium oxalate (CaOx) crystals. Although modern medicine has progressed in terms of removal of these stones, recurrence and persistent side effects restricts their use. Strategies involving plant based agents which could be used as adjunct therapy is an area which needs to be explored. Plant proteins having antilithiatic activity is a hitherto unexplored area and therefore, we conducted a detailed identification and characterization of antilithiatic proteins from Terminalia arjuna (T...
2016: PloS One
https://www.readbyqxmd.com/read/27599009/multi-elements-determination-in-medical-and-edible-alpinia-oxyphylla-and-morinda-officinalis-and-their-decoctions-by-icp-ms
#11
Xiangsheng Zhao, Jianhe Wei, Xiaoyan Shu, Weijun Kong, Meihua Yang
Contents of twenty elements (Mg, K, Ca, Na, Fe, Al, Zn, Ba, Mn, Cu, Mo, Cr, Ni, As, Se, Cd, Hg, Tl, Pb and V) in two medical and edible plant species, Alpinia oxyphylla and Morinda officinalis were simultaneously determined by inductively coupled plasma-mass spectrometry (ICP-MS) method after microwave digestion with HNO3-H2O2 (6:1, v/v) as the digestion solvent. Certified standard reference material Poplar leaf was used to assess the accuracy of the method. The greatest contents of Mg, K, Ca, Al, Fe and Na were found in dried Alpinia oxyphylla and Morinda officinalis samples...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27598852/screening-for-inherited-metabolic-diseases-using-gas-chromatography-tandem-mass-spectrometry-gc-ms-ms-in-sichuan-china
#12
Hong Wang, Xia Wang, Yingying Li, Wei Dai, Dongmei Jiang, Xiaodong Zhang, Yali Cui
The aim of this study was to retrospectively diagnose and confirm inherited metabolic diseases (IMD), from a small population of IMD high-risk patients, with the aid of gas chromatography-tandem mass spectrometry (GC-MS/MS), technologies yet to be popularized in Sichuan, China. Using GC-MS/MS coupled with clinical diagnosis, we retrospectively analyzed samples of dried blood spots and urine specimen from 183 IMD high-risk infant patients, who visited the West China Second Hospital of Sichuan University between June 2013 and October 2015...
September 6, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27585102/development-and-evaluation-of-a-protocol-for-control-of-giardia-duodenalis-in-a-colony-of-group-housed-dogs-at-a-veterinary-medical-college
#13
Meriam N Saleh, Alexandra D Gilley, Meghan K Byrnes, Anne M Zajac
OBJECTIVE To develop and evaluate a protocol for control of Giardia duodenalis in naturally infected group-housed dogs at a veterinary medical college. DESIGN Prospective evaluation study. ANIMALS 34 dogs. PROCEDURES All dogs were tested for evidence of G duodenalis infection. Dogs were treated with fenbendazole on study days 1 through 10. On day 5, dogs were bathed and moved into clean, disinfected kennels in a different room to allow for disinfection and drying of their assigned kennels at 26.7°C (80°F) for 24 hours on day 6...
September 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27563640/design-formulation-and-evaluation-of-ginger-medicated-chewing-gum
#14
Abolfazl Aslani, Alireza Ghannadi, Farnaz Rostami
BACKGROUND: Various ginger compounds improve gastrointestinal problems and motion sickness. The main effects of ginger allocate to some phenolics such as gingerols and shogaols that act as their active agents. Chewing gums are among convenient dosage forms which patients prefer due to their advantages. Hence, this study tried to design, formulate, and evaluate ginger chewing gum of favorable taste and texture to avoid motion sickness and have gastro-protective and anti-oxidant effect...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27556111/changes-in-oral-cavity-during-period-of-intensive-vomiting-in-patient-with-somatoform-autonomic-dysfunction-description-of-the-case
#15
Elżbieta Maria Paszyńska, Agnieszka Słopień, Agata Osińska, Monika Dmitrzak-Węglarz, Andrzej Rajewski, Anna Surdacka
INTRODUCTION: The most important endogenous causes of erosion are eating disorders, gastro-oesophageal reflux (GERD), alcoholism and syndromes involving lowered saliva secretion. AIM: The aim of this work is to study a patient with symptoms of somatoform autonomic dysfunction, in which significant erosive loss occurred through chemical influence of gastric acid on oral cavity. METHODS: Seventeen years old girl was sent to Department of Child and Adolescent Psychiatry due to persistent nausea and vomiting, which occurred over a period of about 10 months...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27516695/the-effect-of-traditional-treatments-on-heavy-metal-toxicity-of-armenian-bole
#16
Ammar Hosamo, Mohammad Mehdi Zarshenas, Alireza Mehdizadeh, Kamiar Zomorodian, Ayda Hossein Khani
BACKGROUND: Clay has been used for its nutrition, cosmetic, and antibacterial properties for thousands of years. Its small particle size, large surface area, and high concentration of ions have made it an interesting subject for pharmaceutical research. There have been studies on scavenging foreign substances and antibacterial properties of clay minerals. The main problem with the medical use of these agents, today, is their heavy metal toxicity. This includes arsenic, cadmium, lead, nickel, zinc, and iron...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27503828/significantly-accelerated-wound-healing-of-full-thickness-skin-using-a-novel-composite-gel-of-porcine-acellular-dermal-matrix-and-human-peripheral-blood-cells
#17
Vijay K Kuna, Arvind M Padma, Joakim Håkansson, Jan Nygren, Robert Sjöback, Sarunas Petronis, Suchitra Sumitran-Holgersson
Herein, we report the fabrication of a novel composite gel from decellularized gal-gal-knockout porcine skin and human peripheral blood mononuclear cells (hPBMC) for full-thickness skin wound healing. Decellularized skin extracellular matrix (ECM) powder was prepared via chemical treatment, freeze-drying and homogenization. The powder was mixed with culture medium containing hyaluronic acid to generate a pig skin gel (PSG). The effect of the gel in regeneration of full-thickness wound was studied in nude mice...
August 5, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27474663/preparation-of-aminated-chitosan-alginate-scaffold-containing-halloysite-nanotubes-with-improved-cell-attachment
#18
Hamideh Amir Afshar, Azadeh Ghaee
The chemical nature of biomaterials play important role in cell attachment, proliferation and migration in tissue engineering. Chitosan and alginate are biodegradable and biocompatible polymers used as scaffolds for various medical and clinical applications. Amine groups of chitosan scaffolds play an important role in cell attachment and water adsorption but also associate with alginate carboxyl groups via electrostatic interactions and hydrogen bonding, consequently the activity of amine groups in the scaffold decreases...
October 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27471845/interventions-for-treating-oral-leukoplakia-to-prevent-oral-cancer
#19
REVIEW
Giovanni Lodi, Roberto Franchini, Saman Warnakulasuriya, Elena Maria Varoni, Andrea Sardella, Alexander R Kerr, Antonio Carrassi, L C I MacDonald, Helen V Worthington
BACKGROUND: Oral leukoplakia is a relatively common oral lesion that, in a small proportion of people, precedes the development of oral cancer. Most leukoplakias are asymptomatic; therefore, the primary objective of treatment should be to prevent onset of cancer. This review updates our previous review, published in 2006. OBJECTIVES: To assess the effectiveness, safety and acceptability of treatments for leukoplakia in preventing oral cancer. SEARCH METHODS: We searched the following electronic databases: Cochrane Oral Health's Trials Register (to 16 May 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2016, Issue 4), MEDLINE Ovid (1946 to 16 May 2016), Embase Ovid (1980 to 16 May 2016) and CancerLit via PubMed (1950 to 16 May 2016)...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27470430/pharmacokinetic-bioequivalence-of-two-inhaled-tiotropium-bromide-formulations-in-healthy-volunteers
#20
Jaime Algorta, Laura Andrade, Marta Medina, Valentin Kirkov, Sacha Arsova, Fumin Li, Jingduan Chi
BACKGROUND AND OBJECTIVE: A novel tiotropium bromide monodose capsule dry powder inhaler (DPI) formulation and device have been developed. The formulation was based on a spray-dried matrix that enhances the aerosolizaton properties, allowing a less active tiotropium metered dose (13 µg/capsule) while maintaining the same delivered dose (10 µg/actuation). This study describes the pharmacokinetic bioequivalence to the reference product. METHODS: This randomized, two-stage, crossover, semi-replicate (three-way) study was performed in healthy volunteers...
September 2016: Clinical Drug Investigation
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