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https://www.readbyqxmd.com/read/28525790/quantitative-lc-hrms-determination-of-selected-cardiovascular-drugs-in-dried-blood-spots-as-an-indicator-of-adherence-to-medication
#1
Dennis Bernieh, Graham Lawson, Sangeeta Tanna
Dried blood spot (DBS) sampling was investigated as a means of obtaining micro-volume blood samples for the quantitative analyses of ten commonly UK prescribed cardiovascular drugs as an indicator of medication adherence. An 8mm disc was punched out from each DBS from calibration, quality control and volunteer samples and extracted using methanol containing the internal standard. Each extract was evaporated to dryness, the residue reconstituted in methanol:water (40:60v/v) containing 0.1% formic acid and analysed by LC-HRMS...
May 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28513733/polylactic-acid-nano-and-microchamber-arrays-for-encapsulation-of-small-hydrophilic-molecules-featuring-drug-release-via-high-intensity-focused-ultrasound
#2
Meiyu Gai, Johannes Frueh, Tianyi Tao, Arseniy V Petrov, Vladimir V Petrov, Evgeniy V Shesterikov, Sergei I Tverdokhlebov, Gleb B Sukhorukov
Long term encapsulation combined with spatiotemporal release for a precisely defined quantity of small hydrophilic molecules on demand remains a challenge in various fields ranging from medical drug delivery, controlled release of catalysts to industrial anti-corrosion systems. Free-standing individually sealed polylactic acid (PLA) nano- and microchamber arrays were produced by one-step dip-coating a PDMS stamp into PLA solution for 5 s followed by drying under ambient conditions. The wall thickness of these hydrophobic nano-microchambers is tunable from 150 nm to 7 μm by varying the PLA solution concentration...
May 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28504347/a-rapid-method-to-screen-poisoning-causative-agents-in-an-acute-care-hospital-in-japan
#3
K Usui, H Mori, T Tachi, T Matsumura, K Mori, A Takeda, Y Noguchi, T Yoshimura, H Teramachi
WHAT IS KNOWN AND OBJECTIVE: A simple, rapid analysis is required to simultaneously analyse medicinal toxicants in emergency medical care. In this regard, the analysis of blood samples by LC-MS/MS equipped with a spin column, involving a rapid, simple pretreatment, has attracted attention. In this study, sample pretreatment using a Monospin C18 column was performed to screen 11 medicinal toxicants in blood samples by LC-MS/MS. METHODS: Serum samples supplemented with 11 medical toxicants-acetaminophen, salicylic acid, nitrazepam, diphenhydramine, bromvalerylurea, phenobarbital, amitriptyline, risperidone, fenitrothion, malathion and methomyl-were pretreated with the Monospin C18 column according to Pretreatment I and Pretreatment II, followed by LC-MS/MS analysis...
May 15, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28501802/stability-of-proteins-in-dried-blood-spot-biobanks
#4
Johan Björkesten, Stefan Enroth, Qiujin Shen, Lotta Wik, David Hougaard, Arieh Cohen, Lene Sörensen, Vilmantas Giedraitis, Martin Ingelsson, Anders Larsson, Masood Kamali-Moghaddam, Ulf Landegren
An important motivation for the construction of biobanks is to discover biomarkers that identify diseases at early, potentially curable stages. This will require biobanks from large numbers of individuals, preferably sampled repeatedly, where the samples are collected and stored under conditions that preserve potential biomarkers. Dried blood samples are attractive for biobanking because of the ease and low cost of collection and storage. Here we have investigated their suitability for protein measurements...
May 13, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28501425/the-effects-of-kratom-on-restraint-stress-induced-analgesia-and-its-mechanisms-of-action
#5
José Luis Vázquez López, Lorenz Schild, Thomas Günther, Stefan Schulz, Hartmud Neurath, Axel Becker
ETHNOPHARMACOLOGICAL RELEVANCE: Mitragyna speciosa and its extracts are called kratom (dried leaves, extract). They contain several alkaloids with an affinity for different opioid receptors. They are used in traditional medicine for the treatment of different diseases, as a substitute by opiate addicts, and to mitigate opioid withdrawal symptoms. Apart from their medical properties, they are used to enhance physical endurance and as a means of overcoming stress. PURPOSE: The aim of this study was to determine the mechanisms underlying the effects of kratom on restraint-stress-induced analgesia which occurs during or following exposure to a stressful or fearful stimulus...
May 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28495190/antibodies-to-toxoplasma-gondii-and-leishmania-spp-in-domestic-cats-from-luanda-angola
#6
Ana Patrícia Lopes, Ana Cristina Oliveira, Sara Granada, Filipa T Rodrigues, Elias Papadopoulos, Henk Schallig, Jitender P Dubey, Luís Cardoso
Toxoplasma gondii and Leishmania spp. are zoonotic protozoa of importance to animal and public health. The present study aimed to assess for the first time the seroprevalence of these zoonotic parasites in a domestic feline population living in Luanda, Angola. One hundred and two cats were sampled at a veterinary medical centre, from May 2014 to February 2016. The age of the cats ranged from 2.5 to 143 months (median: 12 months; interquartile range: 7.5-24). Serum samples were tested for immunoglobulin (Ig) G antibodies to T...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28493805/creating-three-dimensional-printed-models-of-acetabular-fractures-for-use-as-educational-tools
#7
Matthew S Manganaro, Yoav Morag, William J Weadock, Corrie M Yablon, Kara Gaetke-Udager, Erica B Stein
Acetabular fractures are frequently encountered in some clinical practices, and the precise classification of these fractures greatly influences treatments and outcomes. The authors identified the need for an educational aid when teaching acetabular fracture classifications, given the complex spatial anatomy and the nonintuitive classification system that is commonly used. Three-dimensional ( 3D three-dimensional ) printing is an evolving technique that has applications as an educational aid, providing the student with a tangible object to interact with and learn from...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28492472/molecular-surveillance-of-cronobacter-spp-isolated-from-a-wide-variety-of-foods-from-44-different-countries-by-sequence-typing-of-16s-rrna-rpob-and-o-antigen-genes
#8
Nancy Miranda, Pratik Banerjee, Steven Simpson, Khalil Kerdahi, Irshad M Sulaiman
Cronobacter spp. are emerging infectious bacteria that can cause acute meningitis and necrotizing enterocolitis in neonatal and immunocompromised individuals. Although this opportunistic human-pathogenic microorganism has been isolated from a wide variety of food and environmental samples, it has been primarily linked to foodborne outbreaks associated with powdered infant formula. The U.S. Food and Drug Administration use the presence of these microbes as one of the criteria to assess food adulteration and to implement regulatory actions...
May 11, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28463880/medication-adherence-condom-use-and-sexually-transmitted-infections-in-australian-prep-users-interim-results-from-the-victorian-prep-demonstration-project
#9
Luxi Lal, Jennifer Audsley, Dean Murphy, Christopher K Fairley, Mark Stoove, Norm Roth, Richard Moore, B K Tee, Nalagafiar Puratmaja, Peter L Anderson, David Leslie, Robert M Grant, John De Wit, Edwina Wright
OBJECTIVE: HIV Pre-exposure prophylaxis (PrEP) decreases risk of HIV acquisition however its efficacy is closely dependent on adherence. There is also concern that the preventive effect of PrEP may be offset by risk compensation, notably an increase in condomless anal sex. DESIGN: Multi-site, open-label demonstration study that recruited people at current or recent risk of HIV infection in Melbourne, Australia. METHODS: Participants were recruited from three general practice clinics and one sexual health clinic in Melbourne and consented to take daily tenofovir/emtricitabine for 30 months...
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28458701/is-herbal-therapy-safe-in-obesity-a-case-of-apium-graveolens-celery-induced-hyperthyroidism
#10
Hojjat Rouhi-Boroujeni, Masih Hosseini, Mojgan Gharipour, Hamid Rouhi-Boroujeni
BACKGROUND: Apium graveolens is one of the well-known herbs used for the treatment of different; however, allergic reactions have been reported after its use. This report aimed to demonstrate the A. graveolens induced hyperthyroidism after its oral consumption for weight loss. CASE REPORT: Mr. A, 48-year-old, with no history of any thyroid diseases, was diagnosed with hyperthyroidism due to daily consumption of 4 g of dried celery leaves for 45 days. After cessation of consumption and treatment with methimazole, the symptoms remitted...
September 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28456049/silk-fibroin-thelebolan-matrix-a-promising-chemopreventive-scaffold-for-soft-tissue-cancer
#11
Sourav K Mukhopadhyay, Deboki Naskar, Promita Bhattacharjee, Abheepsa Mishra, Subhas C Kundu, Satyahari Dey
Research of improved functional bio-mimetic matrix for regenerative medicine is currently one of the rapidly growing fields in tissue engineering and medical sciences. This study reports a novel bio-polymeric matrix, which is fabricated using silk protein fibroin from Bombyx mori silkworm and fungal exopolysaccharide Thelebolan from Antarctic fungus Thelebolus sp. IITKGP-BT12 by solvent evaporation and freeze drying method. Natural cross linker genipin is used to imprison the Thelebolan within the fibroin network...
April 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28414191/instant-odfs-development-of-an-intermediate-nanoparticle-based-product-platform-for-individualized-medication
#12
Denise Steiner, Jan Henrik Finke, Arno Kwade
The individualization of solid dosage forms to realize a flexible therapy for all patient groups is a topic which increasingly gains importance in pharmaceutical research. The goal of this study was to develop a nanoparticulate, instant orodispersible film (iODF) powder which can easily be reconstituted in water to cast ODFs containing an individualized concentration of an active pharmaceutical ingredient (API). It was shown that the processing of the film casing mass to iODF powders by spray drying provides the same advantageous film properties, particles sizes redispersed from the ODF and dissolution profiles as compared to the common production route...
April 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28413108/moisturisers-in-scar-management-following-burn-a-survey-report
#13
Tanja Klotz, Rochelle Kurmis, Zachary Munn, Kathryn Heath, John Greenwood
Scar management is a recognised key component of rehabilitation following burn. Moisturising often combined with massage is commenced once healing tissue has gained sufficient strength to tolerate surface friction, with the aim being to hydrate the dry scar. The studies on various moisturisers and creams provide some guidance on moisturiser selection, but many are inconclusive. OBJECTIVE: This survey aimed to determine the current expert opinion regarding moisturiser recommendations, including the basis for these recommendations, across the burns community...
April 13, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28403748/an-effective-method-of-atelocollagen-type-1-3-isolation-from-human-placenta-and-its-in-vitro-characterization-in-two-dimesional-and-three-dimensional-cell-culture-applications
#14
Johannes Hackethal, Severin Mühleder, Alexandra Hofer, Karl Heinrich Schneider, Johanna Prüller, Simone Hennerbichler, Heinz Redl, Andreas Teuschl
Pepsin-solubilized atelocollagen can be used to form highly complex three-dimensional matrices for a broad spectrum of tissue engineering applications. Moreover, it has a long history as a favorable biomaterial in pharmaceutical and medical industries. So far, the main sources for these approaches are collagens from xenogenic sources. Yet, these nonhuman collagens carry a risk of provoking immune reactions in patients. Here we describe an effective method of isolating atelocollagen type 1/3 (COL1/3) from human placenta...
May 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28385244/novel-ethanol-induced-pectin-xanthan-aerogel-coatings-for-orthopedic-applications
#15
Gabrijela Horvat, Klodian Xhanari, Matjaž Finšgar, Lidija Gradišnik, Uroš Maver, Željko Knez, Zoran Novak
In this study, we developed a novel high methoxyl pectin-xanthan aerogel coating on medical-grade stainless steel, prepared by ethanol-induced gelation and subsequent supercritical drying. Two non-steroidal anti-inflammatory drugs, i.e. diclofenac sodium and indomethacin, were incorporated into the aerogel coating. Electrochemical analyses were performed on the coated samples using electrochemical impedance spectroscopy and cyclic polarization techniques. The results showed that all passivated samples were highly resistant to general corrosion...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28370991/polyethylene-versus-cotton-caps-as-adjunct-to-body-wrap-in-preterm-infants
#16
Shafie Hashim, Syed Zulkifli Syed Zakaria, Adli Ali, Shareena Ishak, Jaafar Rohana
BACKGROUND: Occlusive body wrap using polyethylene plastic applied immediately after birth had been shown to reduce hypothermia among preterm infants. Various adjunct methods have been studied in an attempt to further reduce the incidence of hypothermia. This study was conducted to determine whether polyethylene cap is more effective than cotton cap as an adjunct to polyethylene occlusive body wrap in reducing hypothermia among preterm infants. METHODS: Study subjects were preterm infants of 24 to 34 weeks gestation born at Universiti Kebangsaan Malaysia Medical Centre (UKMMC)...
March 29, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28361454/self-report-and-dry-blood-spot-measurement-of-antiretroviral-medications-as-markers-of-adherence-in-pregnant-women-in-rural-south-africa
#17
Maria L Alcaide, Shandir Ramlagan, Violeta J Rodriguez, Ryan Cook, Karl Peltzer, Stephen M Weiss, Sibusiso Sifunda, Deborah L Jones
Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0...
March 30, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28331623/gum-arabic-as-novel-anti-oxidant-agent-in-sickle-cell-anemia-phase-ii-trial
#18
Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih, Florian Lang, Amal M Saeed
BACKGROUND: Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28318369/high-rate-of-hepatitis-b-virus-infection-among-hairdressers-in-ibadan-nigeria
#19
B A Olusola, E A Gometi, O Ogunsemowo, D O Olaleye, G N Odaibo
Hepatitis B virus (HBV) infection is a major public health problem for over two billion people infected globally. Occupationally exposed persons are at high risk of HBV infection and, apart from medical personnel, there is dearth of information concerning the prevalence and awareness of HBV among this population in Nigeria. This study was designed to determine the levels of HBV awareness and prevalence of HBV infection among hairdressers in Ibadan, Nigeria. Hairdressers and teachers (unmatched controls) in four local government areas in Ibadan were tested for HBV infection using ELISA technique...
March 20, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28317780/structural-physicochemical-and-biological-properties-of-spray-dried-wine-powders
#20
Agnieszka Wilkowska, Agata Czyżowska, Wojciech Ambroziak, Janusz Adamiec
Different fruit wines, chokeberry, blackcurrant and blueberry, were spray-dried using hydroxypropyl-β-cyclodextrin (HP-β-CD) and inulin (IN). The structural, physicochemical, and biological properties of the spray-dried wine powders were studied over 12months of storage in darkness at 8°C. Identification and quantification of single phenolic compounds before and after storage revealed that HP-β-CD had a positive effect on anthocyanin retention during storage for all microcapsules tested. Similar decreases in anthocyanin were found for blackcurrant and chokeberry powders, ranging from 7...
August 1, 2017: Food Chemistry
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