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https://www.readbyqxmd.com/read/28414191/instant-odfs-development-of-an-intermediate-nanoparticle-based-product-platform-for-individualized-medication
#1
Denise Steiner, Jan Henrik Finke, Arno Kwade
The individualization of solid dosage forms to realize a flexible therapy for all patient groups is a topic which increasingly gains importance in pharmaceutical research. The goal of this study was to develop a nanoparticulate, instant orodispersible film (iODF) powder which can easily be reconstituted in water to cast ODFs containing an individualized concentration of an active pharmaceutical ingredient (API). It was shown that the processing of the film casing mass to iODF powders by spray drying provides the same advantageous film properties, particles sizes redispersed from the ODF and dissolution profiles as compared to the common production route...
April 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28413108/moisturisers-in-scar-management-following-burn-a-survey-report
#2
Tanja Klotz, Rochelle Kurmis, Zachary Munn, Kathryn Heath, John Greenwood
Scar management is a recognised key component of rehabilitation following burn. Moisturising often combined with massage is commenced once healing tissue has gained sufficient strength to tolerate surface friction, with the aim being to hydrate the dry scar. The studies on various moisturisers and creams provide some guidance on moisturiser selection, but many are inconclusive. OBJECTIVE: This survey aimed to determine the current expert opinion regarding moisturiser recommendations, including the basis for these recommendations, across the burns community...
April 13, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28403748/a-cost-effective-method-of-atelo-collagen-type-1-3-col1-3-isolation-from-human-placenta-and-its-in-vitro-characterization-in-2d-and-3d-cell-culture-applications
#3
Johannes Hackethal, Severin Mühleder, Alexandra Hofer, Karl Heinrich Schneider, Johanna Prüller, Simone Hennerbichler, Johann Eibl, Heinz Redl, Andreas Herbert Teuschl
Pepsin-solubilized atelocollagen can be used to form highly complex three-dimensional matrices for a broad spectrum of tissue engineering applications. Moreover, it has a long history as a favorable biomaterial in pharmaceutical and medical industries. So far, the main sources for these approaches are collagens from xenogenic sources. Yet, these non-human collagens carry a risk of provoking immune reactions in patients. Here, we describe an effective method of isolating atelocollagen type 1/3 (COL1/3) from human placenta...
April 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28385244/novel-ethanol-induced-pectin-xanthan-aerogel-coatings-for-orthopedic-applications
#4
Gabrijela Horvat, Klodian Xhanari, Matjaž Finšgar, Lidija Gradišnik, Uroš Maver, Željko Knez, Zoran Novak
In this study, we developed a novel high methoxyl pectin-xanthan aerogel coating on medical-grade stainless steel, prepared by ethanol-induced gelation and subsequent supercritical drying. Two non-steroidal anti-inflammatory drugs, i.e. diclofenac sodium and indomethacin, were incorporated into the aerogel coating. Electrochemical analyses were performed on the coated samples using electrochemical impedance spectroscopy and cyclic polarization techniques. The results showed that all passivated samples were highly resistant to general corrosion...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28370991/polyethylene-versus-cotton-caps-as-adjunct-to-body-wrap-in-preterm-infants
#5
Shafie Hashim, Syed Zulkifli Syed Zakaria, Adli Ali, Shareena Ishak, Jaafar Rohana
BACKGROUND: Occlusive body wrap using polyethylene plastic applied immediately after birth had been shown to reduce hypothermia among preterm infants. Various adjunct methods have been studied in an attempt to further reduce the incidence of hypothermia. This study was conducted to determine whether polyethylene cap is more effective than cotton cap as an adjunct to polyethylene occlusive body wrap in reducing hypothermia among preterm infants. METHODS: Study subjects were preterm infants of 24 to 34 weeks gestation born at Universiti Kebangsaan Malaysia Medical Centre (UKMMC)...
March 29, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28361454/self-report-and-dry-blood-spot-measurement-of-antiretroviral-medications-as-markers-of-adherence-in-pregnant-women-in-rural-south-africa
#6
Maria L Alcaide, Shandir Ramlagan, Violeta J Rodriguez, Ryan Cook, Karl Peltzer, Stephen M Weiss, Sibusiso Sifunda, Deborah L Jones
Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0...
March 30, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28331623/gum-arabic-as-novel-anti-oxidant-agent-in-sickle-cell-anemia-phase-ii-trial
#7
Lamis Kaddam, Imad Fadl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mohammed Abdelraman Salih, Florian Lang, Amal M Saeed
BACKGROUND: Sickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28318369/high-rate-of-hepatitis-b-virus-infection-among-hairdressers-in-ibadan-nigeria
#8
B A Olusola, E A Gometi, O Ogunsemowo, D O Olaleye, G N Odaibo
Hepatitis B virus (HBV) infection is a major public health problem with over two billion people infected globally. Occupationally exposed persons are at high risk of HBV infection. Apart from medical personnel, there is dearth of information as regards the prevalence and awareness of HBV among occupationally exposed persons in the country. This study was designed to determine the levels of HBV awareness and prevalence of HBV infection among hairdressers in Ibadan, Nigeria. Hairdressers and teachers (unmatched controls) in four local government areas in Ibadan were tested for HBV infection using ELISA technique...
March 20, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28317780/structural-physicochemical-and-biological-properties-of-spray-dried-wine-powders
#9
Agnieszka Wilkowska, Agata Czyżowska, Wojciech Ambroziak, Janusz Adamiec
Different fruit wines, chokeberry, blackcurrant and blueberry, were spray-dried using hydroxypropyl-β-cyclodextrin (HP-β-CD) and inulin (IN). The structural, physicochemical, and biological properties of the spray-dried wine powders were studied over 12months of storage in darkness at 8°C. Identification and quantification of single phenolic compounds before and after storage revealed that HP-β-CD had a positive effect on anthocyanin retention during storage for all microcapsules tested. Similar decreases in anthocyanin were found for blackcurrant and chokeberry powders, ranging from 7...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28306757/effect-of-moderate-intensity-exercise-training-on-peak-oxygen-consumption-in-patients-with-hypertrophic-cardiomyopathy-a-randomized-clinical-trial
#10
Sara Saberi, Matthew Wheeler, Jennifer Bragg-Gresham, Whitney Hornsby, Prachi P Agarwal, Anil Attili, Maryann Concannon, Annika M Dries, Yael Shmargad, Heidi Salisbury, Suwen Kumar, Jonathan Herrera, Jonathan Myers, Adam S Helms, Euan A Ashley, Sharlene M Day
Importance: Formulating exercise recommendations for patients with hypertrophic cardiomyopathy is challenging because of concern about triggering ventricular arrhythmias and because a clinical benefit has not been previously established in this population. Objective: To determine whether moderate-intensity exercise training improves exercise capacity in adults with hypertrophic cardiomyopathy. Design, Setting, and Participants: A randomized clinical trial involving 136 patients with hypertrophic cardiomyopathy was conducted between April 2010 and October 2015 at 2 academic medical centers in the United States (University of Michigan Health System and Stanford University Medical Center)...
April 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28301017/intracanal-irrigating-solutions-prior-to-calcium-hydroxide-medication-and-its-effects-on-root-dentin-strength
#11
Leila Clarisse Hillesheim, Juliara Bellina Hoffmann, Daniela Peressoni Vieira Schuldt, Maybell Tedesco, Eduardo Antunes Bortoluzzi, Cleonice Silveira Teixeira
The aim of this study was to assess the effects of intracanal irrigation with sodium hypochlorite (NaOCl) and ethylenediaminetetracetic acid (EDTA) prior to calcium hydroxide medication on the compressive strength of root dentin. Forty-eight roots with single and straight canals were instrumented with a crown-down technique using Flexofile files and Gates Glidden burs, under 0.9% sodium chloride (NaCl) irrigation. Root canals were randomly separated into 4 groups (n=12), according to the irrigating solution: Control Group, 0...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28295603/rapid-abo-genotyping-by-high-speed-droplet-allele-specific-pcr-using-crude-samples
#12
Chiaki Taira, Kazuyuki Matsuda, Naoya Takeichi, Satomi Furukawa, Mitsutoshi Sugano, Takeshi Uehara, Nobuo Okumura, Takayuki Honda
BACKGROUND: ABO genotyping has common tools for personal identification of forensic and transplantation field. We developed a new method based on a droplet allele-specific PCR (droplet-AS-PCR) that enabled rapid PCR amplification. We attempted rapid ABO genotyping using crude DNA isolated from dried blood and buccal cells. METHODS: We designed allele-specific primers for three SNPs (at nucleotides 261, 526, and 803) in exons 6 and 7 of the ABO gene. We pretreated dried blood and buccal cells with proteinase K, and obtained crude DNAs without DNA purification...
March 13, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28294162/sporicidal-activity-of-ceragenin-csa-13-against-bacillus-subtilis
#13
Ewelina Piktel, Katarzyna Pogoda, Maciej Roman, Katarzyna Niemirowicz, Grażyna Tokajuk, Marta Wróblewska, Beata Szynaka, Wojciech M Kwiatek, Paul B Savage, Robert Bucki
Spore-forming bacteria are a class of microorganisms that possess the ability to survive in extreme environmental conditions. Morphological features of spores assure their resistance to stress factors such as high temperature, radiation, disinfectants, and drying. Consequently, spore elimination in industrial and medical environments is very challenging. Ceragenins are a new class of cationic lipids characterized by a broad spectrum of bactericidal activity resulting from amphipathic nature and membrane-permeabilizing properties...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290213/cardamom-fruits-as-a-green-resource-for-facile-synthesis-of-gold-and-silver-nanoparticles-and-their-biological-applications
#14
Veronika Soshnikova, Yeon Ju Kim, Priyanka Singh, Yue Huo, Josua Markus, Sungeun Ahn, Verónica Castro-Aceituno, Jongpyo Kang, Mohan Chokkalingam, Ramya Mathiyalagan, Deok Chun Yang
Gold (FA-AuNps) and silver (FA-AgNps) nanoparticles were synthesized at room temperature by aqueous extract of dried fruits of Amomum villosum, also known as Fructus Amomi (cardamom), in order to confer antioxidant, catalytic, antimicrobial activities and treatment effect against breast cancer cells. Fruit extracts served as both reducing agents and stabilizers in lieu of chemical agents. Ultra-violet visible (UV-Vis) spectroscopy, field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray powder diffraction (XRD), selected area electron diffraction (SAED), dynamic light scattering (DLS) and Fourier transform infrared (FTIR) spectroscopy were employed to characterize the biosynthesized nanoparticles...
March 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28287572/rapid-mix-preparation-of-bioinspired-nanoscale-hydroxyapatite-for-biomedical-applications
#15
Caroline J Wilcock, Piergiorgio Gentile, Paul V Hatton, Cheryl A Miller
Hydroxyapatite (HA) has been widely used as a medical ceramic due to its good biocompatibility and osteoconductivity. Recently there has been interest regarding the use of bioinspired nanoscale hydroxyapatite (nHA). However, biological apatite is known to be calcium-deficient and carbonate-substituted with a nanoscale platelet-like morphology. Bioinspired nHA has the potential to stimulate optimal bone tissue regeneration due to its similarity to bone and tooth enamel mineral. Many of the methods currently used to fabricate nHA both in the laboratory and commercially, involve lengthy processes and complex equipment...
February 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28250652/cosmeceutical-effects-of-galactomannan-fraction-from-arenga-pinnata-fruits-in-vitro
#16
Yanti, Madriena, Soegianto Ali
BACKGROUND: Cosmeceuticals refer to natural cosmetics with medical-like benefits due to their bioactive contents. Sugar palm fruit (Arenga pinnata) extract has been claimed for its anti-aging effect in vitro. However, its active compounds for cosmeceuticals is still unclear. OBJECTIVE: This study was aimed to extract galactomannan from A. pinnata fruits and test its efficacy for tyrosinase inhibition, antioxidant, and anti-photoaging activities in vitro. MATERIALS AND METHODS: Galactomannan from A...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28217981/composition-antifungal-and-antiproliferative-activities-of-the-hydrodistilled-oils-from-leaves-and-flower-heads-of-pterocephalus-nestorianus-nab
#17
Fuad O Abdullah, Faiq H S Hussain, Barbara Mannucci, Rosamaria Lappano, Solveig Tosi, Marcello Maggiolini, Giovanni Vidari
This paper reports the first study of the chemical composition, and antifungal and antiproliferative properties of the volatile extracts obtained by hydrodistillation of the flower heads and leaves of the traditional Kurdish medicinal plant P. nestorianus Nab., collected in the wild. A total of fifty-five constituents, 43 of the flower heads' oil (PFO) and 46 of the leaves' oil (PLO), respectively, were identified by GC/MS, constituting 99.68% and 99.04% of the two oils, respectively. The oils were obtained in 0...
February 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28216881/specific-pcr-identification-between-peucedanum-praeruptorum-and-angelica-decursiva-and-identification-between-them-and-adulterant-using-dna-barcode
#18
Bang-Xing Han, Yuan Yuan, Lu-Qi Huang, Qun Zhao, Ling-Ling Tan, Xiang-Wen Song, Xiao-Mei He, Tao Xu, Feng Liu, Jian Wang
BACKGROUND: The traditional Chinese medicine (TCM) Qianhu and Zihuaqianhu are the dried roots of Peucedanum praeruptorum and Angelica decursiva, respectively. Since the plant sources of Qianhu and Zihuaqianhu are more complex, the chemical compositions of P. praeruptorum and A. decursiva are significantly different, and many adulterants exist because of the differences in traditional understanding and medication habits. Therefore, the rapid and accurate identification methods are required...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28207572/cross-reactivity-of-chloroquine-and-hydroxychloroquine-with-dri-amphetamine-immunoassay
#19
Isabel Gomila, Loreto Quesada, Victoria López-Corominas, Julia Fernández, Miguel Á Servera, Laura Sahuquillo, Macarena Dastis, Albert Torrents, Bernardino Barceló
BACKGROUND: Chloroquine and hydroxychloroquine are medical drugs used to treat the chemoprophylaxis of malaria and a second-line anti-inflammatory drug. METHODS: We performed a study of cross-reactivity of chloroquine and hydroxychloroquine in the DRI Amphetamine Assay inspired by a case report of a self-ingestion of chloroquine after a family dispute, that involved the following: (1) an in vitro study with control samples of healthy subjects, (2) an in vivo study with samples of patients with rheumatoid arthritis, and (3) an evaluation of the cross-reactivity of chloroquine and hydroxychloroquine in 3 additional immunoassays...
April 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28205099/evaluation-of-potentially-drug-related-patient-reported-common-symptoms-assessed-during-clinical-medication-reviews-a-cross-sectional-observational-study
#20
Tim W A Schoenmakers, Martina Teichert, Michel Wensing, Peter A G M de Smet
INTRODUCTION: Healthcare professionals tend to consider common non-alarming drug-related symptoms to be of little clinical relevance. However, such symptoms can have a substantial impact on the individual patient. Insight into patient-reported symptoms could aid pharmacists to identify improvements in medication treatment, for instance in the patient interview at the start of a clinical medication review (CMR). OBJECTIVE: The objectives of this study were to describe the numbers and types of patient-reported symptoms assessed during a CMR and to elucidate their potential association with the drugs in use...
February 15, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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