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https://www.readbyqxmd.com/read/29885208/leveraging-digital-health-technologies-and-outpatient-sampling-in-clinical-drug-development-a-phase-1-exploratory-study
#1
Marissa F Dockendorf, Gowri Murthy, Kevin P Bateman, Prajakti A Kothare, Melanie Anderson, Iris Xie, Jeff R Sachs, Rubi Burlage, Andra Goldman, Matthew Moyer, Jyoti Shah, Rachel Ruba, Lisa Shipley, Jane Harrelson
Merck & Co., Inc. (Kenilworth, New Jersey) is investing in approaches to enrich clinical trial data and augment decision-making through utilization of digital health technologies, outpatient sampling, and real-time data access. As part of this strategy, a Phase 1 study was conducted to explore a few technologies of interest. In this fixed-sequence, two-period trial, 16 healthy subjects were administered 50-mg once-daily sitagliptin packaged in a bottle that electronically captured the date and time study medication was dispensed (Period 1) and in a traditional pharmacy bottle (Period 2)...
June 9, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29881683/inhalation-treatment-of-primary-lung-cancer-using-liposomal-curcumin-dry-powder-inhalers
#2
Tongtong Zhang, Yanming Chen, Yuanyuan Ge, Yuzhen Hu, Miao Li, Yiguang Jin
Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low water solubility, poor bioavailability and rapid metabolism significantly limits clinical applications. Here we developed a liposomal curcumin dry powder inhaler (LCD) for inhalation treatment of primary lung cancer. LCDs were obtained from curcumin liposomes after freeze-drying. The LCDs had a mass mean aerodynamic diameter of 5...
May 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29868685/a-tenuous-pas-de-deux-examining-university-dancers-access-to-and-satisfaction-with-healthcare-delivery
#3
Tina J Wang, Jeffrey A Russell
BACKGROUND: Dance is a rigorous art form and athletic activity accompanied by a high injury rate. The purpose of this study was to gather injury and healthcare availability information from university dancers to better understand dancers' access to professional medical attention and their satisfaction with the medical advice they receive. METHODS: An author-designed online questionnaire about dance-related injury (DRI), access to healthcare, and satisfaction with healthcare was distributed to dancers at 102 American post-secondary institutions in 2 states that offer programs in dance; 211 dancers completed the survey...
June 2018: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/29843862/multiresidue-method-of-analysis-of-pesticides-in-medical-cannabis
#4
Jonathan R Moulins, Michel Blais, Kim Montsion, Josee Tully, William Mohan, Mathieu Gagnon, Tyler McRitchie, Keri Kwong, Neil Snider, David R Blais
Three related analytical methods were developed and validated for the determination of pesticides in cannabisleaves, dried cannabis flowers, and cannabis oil. The methods follow the generic sequence of an acetonitrile extraction, followed by solid-phase extraction cleanup and analysis by HPLC-tandem mass spectrometry (HPLC-MS/MS), GC-MS/MS, and GC-MS. These methods were developed to accommodate sample quantity and lipid content of the different matrices. Validation at a spiking level of 0.01 μg/g was successful for 39 pesticides in cannabis leaves and 40 pesticides in cannabis oil, and at 0...
May 29, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29793555/factors-affecting-use-of-ballistics-gelatin-in-laboratory-studies-of-bacterial-contamination-in-projectile-wounds
#5
Jessica J Evans, Aaron Bost, Karim H Muci-Küchler, Linda C DeVeaux
BACKGROUND: Ballistics gelatin is a common tissue surrogate used in bacterial contamination models for projectile wounds. Although these studies have demonstrated that bacteria are transferred from the surface of the gelatin to the wound track by a projectile, quantifiable results have been inconsistent and not repeatable in successive tests. METHODS: In this study, five areas of a typical contamination model in which bacterial recovery or survival are affected were identified for optimization...
May 25, 2018: Military Medical Research
https://www.readbyqxmd.com/read/29783039/the-influence-of-bone-cement-and-american-society-of-anesthesiologists-asa-class-on-cardiovascular-status-during-bipolar-hemiarthroplasty-for-displaced-femoral-neck-fracture-a-multicenter-prospective-case-control-study
#6
Shuichi Miyamoto, Junichi Nakamura, Satoshi Iida, Tomonori Shigemura, Shunji Kishida, Isao Abe, Munenori Takeshita, Makoto Otsuka, Yoshitada Harad, Sumihisa Orita, Seiji Ohtori
BACKGROUND: Little is known about how bone cement and American Society of Anesthesiologists (ASA) classification influence the cardiovascular system in elderly patients with femoral-neck fractures treated with cemented hemiarthroplasty. Therefore, we performed a case-control study to investigate these questions and compared the following: 1) ≥ASA III with ≤ASA II patients who underwent cemented hemiarthroplasty; 2) cemented with cementless hemiarthroplasty in ≥ASA III patients. HYPOTHESIS: ASA classification influences the cardiovascular system during cemented hemiarthroplasty and bone cement influences intraoperative blood pressure [IBP] in patients rated ≥ASA III...
May 18, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29775684/virulence-determinants-biofilm-production-and-antimicrobial-susceptibility-in-staphylococcus-aureus-causing-device-associated-infections-in-a-tunisian-hospital
#7
I Mesrati, M Saidani, M Jemili, S Ferjeni, A Slim, I Boutiba-Ben Boubaker
Staphylococcus aureus is clinically relevant pathogen that cause device-related infections driven by several virulence factors. In this study we characterize S. aureus isolates involved in medical device-related infections in Tunisian patients. Forty consecutive S. aureus strains causing device-related infections (DRI group) and 47 randomly selected S. aureus strains causing non-device-related infections (NDRI group) were collected. All strains were phenotypically screened for antibiotic susceptibility and biofilm forming ability...
May 15, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29749999/freeze-dried-equine-derived-redback-spider-antivenom-a-local-irritation-study-by-intramuscular-injection-in-rabbits-and-a-repeated-dose-toxicity-study-in-rats
#8
Akihiko Yamamoto, Satomi Harano, Noriko Shinya, Ayataka Nagano, Yoshinobu Miyatsu, Kyouko Sawabe, Takayuki Matsumura, Manabu Ato, Motohide Takahashi, Hisashi Taki, Toru Hifumi
The redback spider ( Latrodectus hasseltii ) is nonindigenous to Japan but has now spread throughout the country. Bites to humans are rare but can be fatal. We prepared freeze-dried redback spider antivenom for therapeutic use against bites in Japan by immunization of horse plasma. This study included two nonclinical tests of the antivenom: a local irritation study involving a single intramuscular administration to rabbits (with injections of physiological saline and an existing freeze-dried diphtheria antitoxin as control and comparison substances, respectively) and a 2-week repeated intermittent intravenous-dose toxicity study in rats...
April 2018: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29736939/effects-of-silymarin-on-the-metabolic-syndrome-a-review
#9
REVIEW
Maryam Vahabzadeh, Nafise Amiri, Gholamreza Karimi
BACKGROUND: The metabolic syndrome is one of the rising global health problems and medical challenges due to several clinical complications it may cause, for example increasing the risk of myocardial infarction and hypertension. On the other hand, great attention has been directed toward determining the worthiness of herbal medicines. There are emerging studies on preventive and therapeutic effects of silymarin on different components of the metabolic syndrome. Extracted from the dried seeds of milk thistle plant (Silybum marianum L...
May 7, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29713197/effective-prevention-of-sorafenib-induced-hand-foot-syndrome-by-dried-bonito-broth
#10
Kenya Kamimura, Yoko Shinagawa-Kobayashi, Ryo Goto, Kohei Ogawa, Takeshi Yokoo, Akira Sakamaki, Satoshi Abe, Hiroteru Kamimura, Takeshi Suda, Hiroshi Baba, Takayuki Tanaka, Yoshizu Nozawa, Naoto Koyama, Masaaki Takamura, Hirokazu Kawai, Satoshi Yamagiwa, Yutaka Aoyagi, Shuji Terai
Background: Sorafenib (SOR) is a molecular medicine that prolongs the survival of patients with hepatocellular carcinoma (HCC). Therefore, the management of side effects is essential for the longer period of continuous medication. Among the various side effects, hand-foot syndrome (HFS) is the most common, occurring in 30%-50% of patients, and often results in discontinuation of the SOR medication. However, its mechanism has not been clarified, and no effective prevention method has been reported for the symptoms...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29697680/-specialist-s-training-for-laparoscopic-surgery-in-wet-lab-educational-operating-theatre
#11
D A Khubezov, V P Sazhin, A Yu Ogoreltsev, D K Puchkov, S V Rodimov, I S Ignatov, T V Tazina, M A Evsyukova
AIM: To develop system for students training in laparoscopic surgery by using of Wet-lab educational operating theatre. MATERIAL AND METHODS: We have launched laparoscopic surgery teaching program for students of Ryazan State Medical University. This system includes several stages. At the first stage professional selection was carried out on 'dry' laparoscopic simulators among III-IV-year students of medical faculty. So, 10 people were selected. The second stage included theoretical and practical parts consisting of development of basic laparoscopic skills on 'dry' simulators...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29681419/physostigmine-reversal-of-dysarthria-and-delirium-after-iatrogenic-atropine-overdose-from-a-dental-procedure
#12
Jon B Cole, Benjamin S Orozco, Ann M Arens
BACKGROUND: Sublingual atropine, dosed at 0.4-0.8 mg, is used by dentists as an antisialogogue to facilitate and increase the speed of procedures. Concentrated ophthalmic atropine drops (10 mg/mL) are commonly used off-label for this purpose. These highly concentrated drops may result in medication errors, atropine toxicity, and the antimuscarinic toxidrome. We report a case of a man who suffered acute delirium and dysarthria (from dry mouth) after an iatrogenic overdose from a dental procedure...
June 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29663638/healing-bone-lesion-defects-using-injectable-caso-4-capo-4-tcp-bone-graft-substitute-compared-to-cancellous-allograft-bone-chips-in-a-canine-model
#13
Deborah J Hall, Thomas M Turner, Robert M Urban
CaSO4 /CaPO4 -TCP bone graft substitute has been shown to be effective for treatment of bone lesion defects, but its mechanical, histological, and radiographic characteristics have not been studied in direct comparison with a conventional treatment such as cancellous allograft bone. Thirteen canines had a critical-size axial defect created bilaterally into the proximal humerus. CaSO4 /CaPO4 -TCP bone graft substitute (PRO-DENSE™, Wright Medical Technology) was injected into the defect in one humerus, and an equal volume of freeze-dried cancellous allograft bone chips was placed in the contralateral defect...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29662792/quantitative-determination-of-residual-1-4-dioxane-in-three-dimensional-printed-bone-scaffold
#14
Ling Li, Jing Long, Long Li, Huijuan Cao, Tingting Tang, Xinghua Xi, Ling Qin, Yuxiao Lai, Xinluan Wang
Background/Objective: A novel porous scaffold poly (lactide- co -glycolide) and tricalcium phosphate (PLGA/TCP) was developed by three-dimensional printing technology for bone defect repair. As a Class 2 solvent with less severe toxicity, content of residual 1,4-dioxane in this newly developed scaffold should be rigorously controlled when it is translated to clinical use. In this study, a headspace gas chromatography-mass spectrometric (HS-GC-MS) method and related testing protocol were developed for quantitative determination of 1,4-dioxane in the PLGA/TCP composite scaffolds...
April 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661320/thermoplastic-blends-of-chitosan-a-method-for-the-preparation-of-high-thermally-stable-blends-with-polyesters
#15
Rafael Grande, Luiz Antonio Pessan, Antonio J F Carvalho
Chitosan is high potential material for new applications due to its properties, especially its antimicrobial activity, and because it is one of the most abundant natural polymers. However, chitosan can be processed only from solution limiting its applications. Methods for processing chitosan in molten have been a subject of recent interest. One method, involves thermoplastic its blends with poly(vinyl alcohol), however these blends undergo degradation due to acid residues from previous processing steps. Here we described a process to produce thermoplastic blends of poly(vinyl alcohol)-chitosan in a poly(lactic acid) matrix by avoiding degradation even at higher chitosan contents...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29661299/multi-hierarchical-tissue-engineering-ecm-like-scaffolds-based-on-cellulose-acetate-with-collagen-and-chitosan-fillers
#16
Ksenia I Lukanina, Timofei E Grigoriev, Sergey V Krasheninnikov, Vissarion G Mamagulashvilli, Roman A Kamyshinsky, Sergey N Chvalun
A novel high-tech composite biomimetic matrixes for a wide range of medical purposes were prepared. The structure of scaffolds was inspired by the architecture of native decellularized tissue: material consists of a sponge and fibrous components of different spatial geometry based on cellulose acetate with collagen or chitosan filler. The fibrous component was prepared by electrospinning, the sponge - freeze-drying technique. The influence of main technological parameters, such as freeze mode, polymer type and concentration, etc...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29622864/comparison-of-immunohistochemistry-cytochemistry-and-flow-cytometry-in-aml-for-myeloperoxidase-detection
#17
Ankur Ahuja, Seema Tyagi, Tulika Seth, Hara Prasad Pati, Gps Gahlot, Preeti Tripathi, Venkatesan Somasundaram, Renu Saxena
Acute Myeloid Leukemia (AML) as per World Health Organization (WHO 2008) classification is on the basis of the antigenic characterization, enzymes restriction in the neoplastic myeloid cells and the specific translocations/mutations. AML can be assessed and differentiated by flowcytometry (FCM)/immunohistochemistry (IHC)/cytochemistry techniques. Myeloperoxidase (MPO) is an unequivocal marker to differentiate AML from the acute lymphoblastic leukemia. Despite FCM popularity, it has its limitations, in form of 'dry-tap', cost, and inability of being performed by retrospective analysis...
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29607996/-unidirectionally-oriented-membrane-formation-of-supra-polysaccharides-sacran-and-application-to-drug-delivery-system
#18
Kosuke Okeyoshi, Maiko K Okajima, Tatsuo Kaneko
 The geometric structures of soft materials can be controlled on the macro-scale using interfacial or mechanical instability, e.g., fingering patterns of viscous liquid and buckling patterns of gels during swelling/deswelling. These patterns can be used as smart materials for capturing/releasing and mass-transportation applications. Here we introduce the emergence of a uniaxially oriented membrane by drying an aqueous liquid-crystalline solution, composed of megamolecular supra-polysaccharides "sacran", from a limited space...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29605998/humidity-responsive-gold-aerogel-for-real-time-monitoring-of-human-breath
#19
Israt Ali, Liming Chen, Youju Huang, Liping Song, Xuefei Lu, Baoqing Liu, Lei Zhang, Jiawei Zhang, Linxi Hou, Tao Chen
Humidity sensors have received considerable attention in recent years because of their significance and wide applications in agriculture, industries, goods stores, and medical fields. However, the conventional humidity sensors usually possessed a complex sensing mechanism and low sensitivity and required a time-consuming, labor-intensive process. The exploration for an ideal sensing material to amplify the sensitivity of humidity sensors is still a big challenge. Herein, we developed a simple, low-cost, and scalable fabrication strategy to construct a highly sensitive humidity sensor based on polymer/gold nanoparticle (AuNP) hybrid materials...
April 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29602568/evaluation-of-ophthalmic-surgical-instrument-sterility-using-short-cycle-sterilization-for-sequential-same-day-use
#20
David F Chang, Nikki Hurley, Nick Mamalis, Jeffrey Whitman
PURPOSE: The common practice of short-cycle sterilization for ophthalmic surgical instrumentation has come under increased regulatory scrutiny. This study was undertaken to evaluate the efficacy of short-cycle sterilization processing for consecutive same-day cataract procedures. DESIGN: Testing of specific sterilization processing methods by an independent medical device validation testing laboratory. PARTICIPANTS: Phaco handpieces from 3 separate manufacturers were tested along with appropriate biologic indicators and controls using 2 common steam sterilizers...
March 27, 2018: Ophthalmology
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