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https://www.readbyqxmd.com/read/29033138/do-you-believe-it-verbal-suggestions-influence-the-clinical-and-neural-effects-of-escitalopram-in-social-anxiety-disorder-a-randomized-trial
#1
Vanda Faria, Malin Gingnell, Johanna M Hoppe, Olof Hjorth, Iman Alaie, Andreas Frick, Sara Hultberg, Kurt Wahlstedt, Jonas Engman, Kristoffer N T Månsson, Per Carlbring, Gerhard Andersson, Margareta Reis, Elna-Marie Larsson, Mats Fredrikson, Tomas Furmark
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression and anxiety, but their efficacy relative to placebo has been questioned. We aimed to test how manipulation of verbally induced expectancies, central for placebo, influences SSRI treatment outcome and brain activity in patients with social anxiety disorder (SAD). METHODS: We did a randomized clinical trial, within an academic medical center (Uppsala, Sweden), of individuals fulfilling the DSM-IV criteria for SAD, recruited through media advertising...
September 27, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29032922/serotonin-transporter-density-in-binge-eating-disorder-and-pathological-gambling-a-pet-study-with-11-c-madam
#2
Joonas Majuri, Juho Joutsa, Jarkko Johansson, Valerie Voon, Riitta Parkkola, Hannu Alho, Eveliina Arponen, Valtteri Kaasinen
Behavioral addictions, such as pathological gambling (PG) and binge eating disorder (BED), appear to be associated with specific changes in brain dopamine and opioid function, but the role of other neurotransmitter systems is less clear. Given the crucial role of serotonin in a number of psychiatric disorders, we aimed to compare brain serotonergic function among individuals with BED, PG and healthy controls. Seven BED patients, 13 PG patients and 16 healthy controls were scanned with high-resolution positron emission tomography (PET) using the serotonin transporter (SERT) tracer [(11)C]MADAM...
October 9, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29024901/impact-of-initial-medication-non-adherence-to-ssris-on-medical-visits-and-sick-leaves
#3
Ignacio Aznar-Lou, María Iglesias-González, Montserrat Gil-Girbau, Antoni Serrano-Blanco, Ana Fernández, María Teresa Peñarrubia-María, Ramón Sabés-Figuera, Ana Gabriela Murrugarra-Centurión, Marian March-Pujol, Mireia Bolívar-Prados, Maria Rubio-Valera
BACKGROUND: Initial medication non-adherence (IMNA) to antidepressants, which are commonly used to treat depression in primary care (PC), is around 6-12%. Although it is well known that post-initial non-adherence to antidepressants increases the cost of depression, the impact of IMNA on cost is unknown. The aim of this study is to assess the impact of IMNA to Selective Serotonin Reuptake Inhibitors (SSRI) on medical visits and sick leave in patients with depression treated in PC in Catalonia (Spain)...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29024676/perinatal-fluoxetine-prevents-the-effect-of-pre-gestational-maternal-stress-on-5-ht-in-the-pfc-but-maternal-stress-has-enduring-effects-on-mpfc-synaptic-structure-in-offspring
#4
Mary Gemmel, Nikolaos Kokras, Christina Dalla, Jodi L Pawluski
Maternal affective disorders are frequently treated with selective serotonin reuptake inhibitor medications (SSRIs); with up to 10% of women being prescribed these medications during pregnancy. Infant development depends on the early serotonergic environment, which is altered by perinatal SSRIs, raising concern about how these medications affect neural outcomes. While clinical and preclinical research suggests an impact of SSRIs on the developing brain, more research is needed to determine the effects on neuroplasticity, the serotonergic system, and the hypothalamic-pituitary-adrenal axis in neural regions mediating behavior...
October 9, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29016822/platelet-derived-growth-factor-as-an-antidepressant-treatment-selection-biomarker-higher-levels-selectively-predict-better-outcomes-with-bupropion-ssri-combination
#5
Manish K Jha, Abu Minhajuddin, Bharathi S Gadad, Madhukar H Trivedi
Background: Platelet derived growth factor is integral to maintenance of blood brain barrier, increases in response to blood brain barrier disruption, and may reflect neuroinflammation. Based on previous reports of better outcomes with dopaminergic antidepressants in depressed patients with elevated inflammatory biomarkers, we hypothesize that elevated peripheral platelet derived growth factor levels can serve as a powerful biomarker for selecting dopaminergic antidepressants. Methods: Platelet derived growth factor, basic fibroblast growth factor, and granulocyte colony stimulating factor were measured as part of Bioplex Pro human cytokine 27-plex kit in participants of the Combining Medications to Enhance Depression Outcomes trial who provided baseline plasma (n=166) and were treated with either bupropion-plus-escitalopram, escitalopram-plus-placebo, or venlafaxine-plus-mirtazapine...
July 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28953843/what-are-the-risks-associated-with-different-selective-serotonin-re-uptake-inhibitors-ssris-to-treat-depression-and-anxiety-in-pregnancy-an-evaluation-of-current-evidence
#6
Kate Womersley, Katherine Ripullone, Mark Agius
A literature review was conducted to elucidate the respective reproductive safety profiles of different SSRIs to inform the prescribing practices of doctors treating pregnant women with anxiety and depression. BACKGROUND: Women are most likely to be diagnosed with depression or anxiety between the ages of 25 and 44 years, which are also the years of childbearing potential (Burke et al., 1991). Therefore a substantial number of women face a decision about whether or not to take an antidepressant or anxiolytic during pregnancy...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28953776/selective-serotonergic-ssri-versus-noradrenergic-snri-reuptake-inhibitors-with-and-without-acetylsalicylic-acid-in-major-depressive-disorder
#7
Nicolas Zdanowicz, Christine Reynaert, Denis Jacques, Brice Lepiece, Thomas Dubois
BACKGROUND: Antidepressant medication efficacy remains a major research challenge. Here, we explored four questions: whether noradrenergic antidepressants are more effective than serotonergic antidepressants; whether the addition of 100 mg acetylsalicylic acid (ASA) changes antidepressant efficacy; whether the long-term efficacy differs depending on the antidepressant and the addition of ASA; and whether serum levels of brain-derived neurotrophic factor (BDNF) are clinically informative...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28925998/a-critical-period-for-antidepressant-induced-acceleration-of-neuronal-maturation-in-adult-dentate-gyrus
#8
I Åmellem, S Suresh, C C Chang, S S L Tok, A Tashiro
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used medications for mood and anxiety disorders, and adult neurogenesis in the dentate gyrus has been shown to be involved in the behavioral effects of SSRIs in mice. Studies have shown the varied effects of chronic treatment with SSRIs on adult neurogenesis. One such effect is the acceleration of neuronal maturation, which affects the functional integration of new neurons into existing neuronal circuitry. In this study, we labeled new neurons by using GFP-expressing retroviral vectors in mice and investigated the effect of an SSRI, fluoxetine, on these neurons at different time points after neuronal birth...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28917161/maternal-ssri-exposure-increases-the-risk-of-autistic-offspring-a-meta-analysis-and-systematic-review
#9
S Andalib, M R Emamhadi, S Yousefzadeh-Chabok, S K Shakouri, P F Høilund-Carlsen, M S Vafaee, T M Michel
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used to preclude maternal pregnancy depression. There is a growing body of literature assessing the association of prenatal exposure to SSRIs with autism spectrum disorder (ASD). The present systematic review and meta-analysis reviewed the medical literature and pooled the results of the association of prenatal exposure to SSRIs with ASD. METHODS: Published investigations in English by June 2016 with keywords of selective serotonin reuptake inhibitors, SSRI, autism spectrum disorder, ASD, pregnancy, childhood, children, neurodevelopment were identified using databases PubMed and PMC, MEDLINE, EMBASE, SCOPUS, and Google Scholar...
June 20, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28881483/meta-analysis-risk-of-hyperhidrosis-with-second-generation-antidepressants
#10
Chad Beyer, Kiley Cappetta, Jessica A Johnson, Michael H Bloch
BACKGROUND: Our goal was to quantify the risk of hyperhidrosis associated with commonly used antidepressant agents and examine the impact of medication class, pharmacodynamics, and dose on risk of hyperhidrosis. METHODS: We conducted a PubMed search to identify all double-blind, randomized, placebo-controlled trials examining the efficacy of second-generation antidepressant medications in the treatment of adults with a depressive disorder, anxiety disorders, or obsessive-compulsive disorder...
September 7, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28853392/pilot-of-a-randomised-controlled-trial-of-the-selective-serotonin-reuptake-inhibitor-sertraline-versus-cognitive-behavioural-therapy-for-anxiety-symptoms-in-people-with-generalised-anxiety-disorder-who-have-failed-to-respond-to-low-intensity-psychological-treatments
#11
Marta Buszewicz, John Cape, Marc Serfaty, Roz Shafran, Thomas Kabir, Peter Tyrer, Caroline S Clarke, Irwin Nazareth
BACKGROUND: Generalised anxiety disorder (GAD) is common, causing unpleasant symptoms and impaired functioning. The National Institute for Health and Care Excellence (NICE) guidelines have established good evidence for low-intensity psychological interventions, but a significant number of patients will not respond and require more intensive step 3 interventions, recommended as either high-intensity cognitive behavioural therapy (CBT) or a pharmacological treatment such as sertraline. However, there are no head-to-head comparisons evaluating which is more clinically effective and cost-effective, and current guidelines suggest that treatment choice at step 3 is based mainly on patient preference...
August 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28815791/risk-of-preeclampsia-after-gestational-exposure-to-selective-serotonin-reuptake-inhibitors-and-other-antidepressants-a-study-from-the-norwegian-mother-and-child-cohort-study
#12
Angela Lupattelli, Mollie Wood, Kate Lapane, Olav Spigset, Hedvig Nordeng
PURPOSE: To describe the risk of early- and late-onset preeclampsia across pregnancies exposed to antidepressants and to evaluate the impact of timing and length of gestational exposure to antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), on preeclampsia. METHODS: The Norwegian Mother and Child Cohort, a prospective population-based study, and the Medical Birth Registry of Norway provided information on antidepressant exposure, depression, and anxiety symptoms in pregnancy, preeclampsia diagnoses, and important covariates...
October 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28815738/the-effect-of-depression-generalized-anxiety-and-selective-serotonin-reuptake-inhibitors-on-change-in-bone-metabolism-in-adolescents-and-emerging-adults
#13
Chadi A Calarge, James A Mills, Kathleen F Janz, Trudy L Burns, Janet A Schlechte, William H Coryell, Babette S Zemel
OBJECTIVES: To prospectively examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) use to changes in bone metabolism in older adolescents and emerging adults. METHODS: Medically-healthy 15 to 20 year-olds who were unmedicated or within one month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly...
August 16, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28806612/pilots-using-selective-serotonin-reuptake-inhibitors-compared-to-other-fatally-injured-pilots
#14
Paul Rogers, Christy Hileman, Guillermo Salazar, Kacey Cliburn, Lawrence Paskoff, William Hathaway, Kevin Gildea, Victor Hugo Tejera Villalaz
Selective Serotonin Reuptake Inhibitors (SSRI) were a disqualifying medication for U.S. civil pilots before April 5, 2010. After this date, a Federal Aviation Administration policy was created that allowed airmen, on select SSRIs, a pathway to hold a valid medical certificate. The purpose of this study was to provide a detailed look at SSRIs in the U.S. pilot population since the inception of this new policy. We examined the toxicology results from fatally injured airmen in addition to outcomes concerning pilots who are participating in the program...
August 11, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28791695/use-of-antidepressants-and-risk-of-epithelial-ovarian-cancer
#15
Lina S Mørch, Christian Dehlendorff, Louise Baandrup, Søren Friis, Susanne K Kjaer
Antidepressants are widely prescribed among women to treat depression and anxiety disorders, but studies of their effects on gynecological cancer risk are sparse. We assessed associations between various antidepressants and risk of epithelial ovarian cancer. By using Danish nationwide registers, we identified all women (cases) aged 30-84 years with incident epithelial (serous, endometrioid, clear cell or mucinous) ovarian cancer during 2000-2011 (n = 4,103) and matched each case to 20 population controls (n = 58,706) by risk-set matching...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28765248/adherence-and-persistence-with-drug-therapy-among-fibromyalgia-patients-data-from-a-large-health-maintenance-organization
#16
Dana Ben-Ami Shor, Dahlia Weitzman, Shani Dahan, Omer Gendelman, Yael Bar-On, Daniela Amital, Varda Shalev, Gabriel Chodick, Howard Amital
OBJECTIVE: To assess 1-year persistence and adherence rates with drug therapy among patients with fibromyalgia (FM) and to identify factors associated with therapy discontinuation. METHODS: This retrospective, cohort study included members ≥ 21 years old from the Maccabi Healthcare Services, a large health maintenance organization in Israel, who were diagnosed with FM from 2008 through 2011. Medications of interest included the anticonvulsant pregabalin, antidepressants [selective serotonin reuptake inhibitor (SSRI), serotonin/norepinephrine reuptake inhibitor (SNRI)], and tricyclic antidepressants (TCA)...
October 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28759400/body-composition-in-adolescents-during-treatment-with-selective-serotonin-reuptake-inhibitors
#17
Chadi A Calarge, James A Mills, Kathleen F Janz, Trudy L Burns, William H Coryell, Babette S Zemel
OBJECTIVES: To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents. METHODS: Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Body Mass Index (BMI) was measured every 4 months...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28735693/concomitant-use-of-atypical-antipsychotics-with-other-psychotropic-medication-classes-and-the-risk-of-type-2-diabetes-mellitus
#18
Mehmet Burcu, Julie M Zito, Daniel J Safer, Laurence S Magder, Susan dosReis, Fadia T Shaya, Geoffrey L Rosenthal
OBJECTIVE: More than half of youth treated with atypical antipsychotic (AAP) medications are also treated with concomitant antidepressants or stimulants. This study assessed the association between antidepressant or stimulant use concomitant with AAPs and the risk of incident type 2 diabetes mellitus (T2DM). METHOD: Medicaid Analytic eXtract data were used to conduct a retrospective cohort study of youth (aged 5-20 years) who initiated AAP treatment. In AAP-treated youth, concomitant antidepressant (selective serotonin reuptake inhibitors [SSRI]/serotonin-norepinephrine reuptake inhibitors [SNRIs], tricyclic/other cyclic antidepressants [TCAs], and other antidepressants) or stimulant use was assessed...
August 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28735226/perinatal-fluoxetine-effects-on-social-play-the-hpa-system-and-hippocampal-plasticity-in-pre-adolescent-male-and-female-rats-interactions-with-pre-gestational-maternal-stress
#19
Mary Gemmel, Mariah Hazlett, Eszter Bögi, Sonsoles De Lacalle, Lesley A Hill, Nikolaos Kokras, Geoffrey L Hammond, Christina Dalla, Thierry D Charlier, Jodi L Pawluski
Selective serotonin reuptake inhibitor medications (SSRIs) are the first lines of treatment for maternal affective disorders, and are prescribed to up to 10% of pregnant women. Concern has been raised about how perinatal exposure to these medications affect offspring neurobehavioral outcomes, particularly those related to social interactions, as recent research has reported conflicting results related to autism spectrum disorder (ASD) risk in children prenatally exposed to SSRIs. Therefore, the aim of this work was to investigate the effects of perinatal exposure to the SSRI fluoxetine on social play behaviors and the hypothalamic pituitary adrenal system, using a model of pre-gestational maternal stress...
October 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28728805/associations-of-c-reactive-protein-and-psychological-distress-are-modified-by-antidepressants-supporting-an-inflammatory-depression-subtype-findings-from-ukhls
#20
Amanda Hughes, Meena Kumari
BACKGROUND: Clinical evidence increasingly suggests inflammation may be important specifically for an etiologically distinct depression subtype, characterised by resistance to antidepressant medication. However, epidemiological investigations of the relationship of inflammation with depression and psychological distress have failed to acknowledge these developments, which may have resulted in bias or masking of associations driven by the subtype. This may have contributed to inconsistent results in epidemiological studies, and equivocal support for an inflammation-depression link...
July 17, 2017: Brain, Behavior, and Immunity
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