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https://www.readbyqxmd.com/read/29446012/a-meta-analysis-of-the-effects-of-antidepressants-on-cognitive-functioning-in-depressed-and-non-depressed-samples
#1
REVIEW
Catherine E Prado, Stephanie Watt, Simon F Crowe
A thorough understanding of the cognitive effects of antidepressant medications is essential given their frequency of use. This meta-analysis was conducted to investigate whether antidepressants differentially affect the various domains of cognitive functioning for depressed and non-depressed participants. An electronic search of PsycInfo, Medline and Google Scholar was conducted for all journal articles published between January 1998 and January 2017. Thirty-three studies were included enabling calculation of Hedges' g using a random effects model for the cognitive domains of divided attention, executive function, expressive language, immediate memory, perceptual motor skills, processing speed, recent memory, sustained attention, visuospatial-constructional skills and working memory...
February 14, 2018: Neuropsychology Review
https://www.readbyqxmd.com/read/29441424/selective-serotonin-reuptake-inhibitors-ssris-and-markers-of-bone-turnover-in-men
#2
Lana J Williams, Michael Berk, Jason M Hodge, Mark A Kotowicz, Amanda L Stuart, Vinoomika Chandrasekaran, Jasmine Cleminson, Julie A Pasco
Selective serotonin reuptake inhibitors (SSRIs) have been shown to have a clinically significant impact on bone metabolism. To explore this further, we aimed to determine whether these agents are associated with serum markers of bone turnover utilising a population-based sample of men (n = 1138; 20-96 year) participating in the Geelong Osteoporosis Study. Blood samples were obtained and the bone resorption marker, C-telopeptide (CTx) and formation marker, type 1 procollagen amino-terminal-propeptide (PINP) were measured...
February 13, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29435621/effect-of-selective-serotonin-reuptake-inhibitors-on-bone-mineral-density-a-systematic-review-and-meta-analysis
#3
REVIEW
C Zhou, L Fang, Y Chen, J Zhong, H Wang, P Xie
Our work is the first systematic meta-analysis to investigate the effect of selective serotonin reuptake inhibitor (SSRI) medication on bone mineral density. Through meta-analyzed 11 studies, our findings suggested that compared with nonusers, use of SSRIs was significantly associated with lumbar spine BMD reduction, particularly for old people. The use of selective serotonin reuptake inhibitors (SSRIs) has already been associated with bone mass loss. Their effects on bone mineral density (BMD) for the different bone sections have, however, thus been inconsistent...
February 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29435082/escitalopram-oxalate-inhibits-proliferation-and-migration-and-induces-apoptosis-in-non-small-cell-lung-cancer-cells
#4
I Yuan, Chi-Ting Horng, Vincent Chin-Hung Chen, Chun-Hung Chen, Li-Jeng Chen, Tsai-Ching Hsu, Bor-Show Tzang
Population-based cohort studies have revealed that neuroleptic medications are associated with a reduced cancer risk. Recent studies have demonstrated that selective serotonin reuptake inhibitors (SSRIs) have an antiproliferative or cytotoxic effect on certain cancer types. Known as a superior SSRI, escitalopram oxalate exhibits favorable tolerability with generally mild and temporary adverse events. The present study aimed to examine the effects of escitalopram oxalate on non-small cell lung cancer (NSCLC) cells...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432263/perioperative-inpatient-use-of-selective-serotonin-reuptake-inhibitors-is-associated-with-a-reduced-risk-of-tha-and-tka-revision
#5
Jie J Yao, Hilal Maradit Kremers, Walter K Kremers, David G Lewallen, Daniel J Berry
BACKGROUND: Depression is common in the general population, and so it is likewise common among patients undergoing THA and TKA. Depression is associated with lower perioperative patient-reported outcomes and an increased risk of postoperative complications. Antidepressants are effective in managing symptoms of depression and may potentially contribute to better functional status and better clinical outcomes after THA and TKA. QUESTIONS/PURPOSES: We examined (1) whether perioperative depression is associated with all-cause revisions, revisions for aseptic loosening, revisions without infection, and periprosthetic joint infections (PJIs) in patients undergoing THA and TKA; and (2) whether perioperative antidepressant use reduces the risk of all-cause revisions, revisions for aseptic loosening, aseptic revisions, and PJIs in patients undergoing THA and TKA...
February 8, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29351761/selective-serotonin-reuptake-inhibitor-use-and-breast-cancer-survival-a-population-based-cohort-study
#6
John Busby, Ken Mills, Shu-Dong Zhang, Fabio Giuseppe Liberante, Chris R Cardwell
BACKGROUND: Nearly 50% of breast cancer patients suffer from depression or anxiety. Selective serotonin reuptake inhibitors (SSRIs), the first-line pharmacological treatment for depression, have been implicated in breast cancer development through increased prolactin levels and tamoxifen metabolism inhibition. Previous studies of breast cancer progression have focused on tamoxifen users, or have been limited by their small sample size and methodology. Therefore, we used UK population-based data to more robustly investigate the association between SSRI use and cancer-specific mortality...
January 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29344692/the-epidemiology-of-wrist-fractures-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#7
N C Wright, E R Hooker, C M Nielson, K E Ensrud, S L Harrison, E S Orwoll, E Barrett-Connor
There is limited wrist fracture information on men. Our goal was to calculate frequency and identify risk factors for wrist fracture in the Osteoporotic Fractures in Men (MrOS) study. We confirmed that fracture history and certain medications are predictors, and identified novel predictors including markers of kidney function and physical performance. INTRODUCTION: To calculate the incidence of wrist fractures and their risk factors in older community-dwelling men from the US Osteoporotic Fractures in Men (MrOS) study...
January 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29333835/-an-unintended-diagnosis-serotonergic-toxicity-secondary-to-drug-interactions-case-reports
#8
Elda G Cargnel, Patricia C Cardoso, Julián Irigoyen, Sol García Puglisi
Serotonin toxicity is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. It is seen with therapeutic medication use, intentional self-poisoning and inadvertent interactions (SSRI-isoniazid). Although this pathology is increasingly common, it is not well recognized by physicians and manifestations may be wrongly attributed to another cause. The aim of this paper is to describe the clinical picture of a patient, to collaborate on diagnosis and to improve medical care of these patients...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29278206/a-systematic-review-of-evidence-based-treatment-strategies-for-obsessive-compulsive-disorder-resistant-to-first-line-pharmacotherapy
#9
Umberto Albert, Donatella Marazziti, Gabriele Di Salvo, Francesca Solia, Gianluca Rosso, Giuseppe Maina
BACKGROUND: Serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). However, a significant proportion of patients do not respond satisfactorily to first-choice treatments. Several options have been investigated for the management of resistant patients. OBJECTIVE: The aim of the present paper is to systematically review the available literature concerning the strategies for the treatment of resistant adult patients with OCD...
December 22, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29276014/early-selective-serotonin-reuptake-inhibitors-for-recovery-after-stroke-a-meta-analysis-and-trial-sequential-analysis
#10
Si-Chun Gu, Chang-De Wang
BACKGROUND: Potential benefits and risks of early (≤30 days from stroke onset) selective serotonin reuptake inhibitors (SSRIs) treatment for neurologic functional recovery after stroke are not fully understood. METHODS: We searched PubMed, Embase, and the Cochrane Library to identify randomized controlled trials that assessed SSRI medications during the initial ictus after stroke versus placebo. Primary outcome was decrease in National Institutes of Health Stroke Scale (NIHSS) score...
December 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29210786/selective-serotonin-reuptake-inhibitors-and-serotonin-norepinephrine-reuptake-inhibitors-are-not-associated-with-bleeding-or-transfusion-in-cardiac-surgical-patients
#11
Mark M Smith, Bradford B Smith, Brian D Lahr, Gregory A Nuttall, William J Mauermann, Timothy J Weister, Joseph A Dearani, David W Barbara
BACKGROUND: Selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) use is known to alter platelet activation and aggregation leading to impairment in hemostasis. Previous studies are ambiguous with regard to bleeding, transfusion, and perioperative complications in patients undergoing cardiac surgery. The purpose of this study was to evaluate the risk of perioperative bleeding, transfusion, morbidity, and mortality in cardiac surgical patients taking SSRI/SNRIs compared with propensity-matched controls...
November 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29203333/perinatal-fluoxetine-increases-hippocampal-neurogenesis-and-reverses-the-lasting-effects-of-pre-gestational-stress-on-serum-corticosterone-but-not-on-maternal-behavior-in-the-rat-dam
#12
Mary Gemmel, Danny Harmeyer, Eszter Bögi, Marianne Fillet, Lesley A Hill, Geoffrey L Hammond, Thierry D Charlier, Jodi L Pawluski
There is increasing evidence that mental health concerns, stress-related mental illnesses, and parental stress prior to conception have long-term effects on offspring outcomes. However, more work is needed to understand how pre-gestational stress might affect neurobehavioral outcomes in the mother. We investigated how chronic stress prior to gestation affects the maternal behavior and related physiology, and aimed to determine the role that perinatal SSRIs may have in altering these stress effects. To do this, female Sprague-Dawley rats were subject to chronic unpredictable stress (CUS) prior to breeding and during the perinatal period they were administered fluoxetine (10mg/kg/day)...
December 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29200837/the-relationship-of-ssri-and-snri-usage-with-interstitial-lung-disease-and-bronchiectasis-in-an-elderly-population-a-case-control-study
#13
Ted Rosenberg, Rory Lattimer, Patrick Montgomery, Christian Wiens, Liran Levy
Background: The association between interstitial lung disease (ILD) and selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors (SSRI/SNRI) has been previously described in published case reports. However, its prevalence may be more common than expected. We examined the association between SSRI/SNRI usage and presence of ILD and or bronchiectasis (ILD/B) in an elderly population. Methods: We conducted a retrospective case series and case-control study involving all 296 eligible elderly patients in one primary care geriatric practice in Victoria, BC, Canada...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29200012/a-naturalistic-evaluation-of-change-in-antidepressant-prescription-in-patients-with-affective-and-anxiety-disorders-in-a-tertiary-care-hospital-of-india
#14
Amol Patil, Swapnajeet Sahoo, Gaurav Garg, Sandeep Grover
BACKGROUND: Although many studies have evaluated prescription patterns, there is lack of information on the choice of antidepressants among patients who do not respond antidepressants. Similarly, information on switching strategies is also limited. This naturalistic study aimed to evaluate the switching strategies and preferred antidepressants by the psychiatrists among patients who do not respond to or who are not able to tolerate an antidepressant. METHODS: A cross-sectional observational study design was followed...
December 1, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29172802/the-effect-of-antidepressant-medications-in-the-management-of-heart-failure-on-outcomes-mortality-cardiovascular-function-and-depression-a-systematic-review
#15
Thurkka Rajeswaran, Carla M Plymen, Anne M Doherty
OBJECTIVE: Depression is associated with increased morbidity, mortality and hospital readmission in patients with heart failure (HF). This systematic review aimed to compile studies examining whether the use of antidepressants could improve outcome in patients with HF and concomitant depression. METHODS: The electronic libraries Embase, OVID MEDLINE(R) and PsychInfo were used to search the following terms 'heart failure' AND 'anti-depressants'; 'heart failure' AND 'TCA' OR 'SSRI' OR 'SNRI'...
November 26, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29150233/management-of-first-depression-or-generalized-anxiety-disorder-episode-in-adults-in-primary-care-a-systematic-metareview
#16
Damien Driot, Michel Bismuth, Adrien Maurel, Julie Soulie-Albouy, Jordan Birebent, Stéphane Oustric, Julie Dupouy
CONTEXT: General Practitioners (GPs) are the leading antidepressants prescribers in Europe and in France. Difficulties in implementing existing recommendations in daily practice have been described. OBJECTIVE: The objective of this study was to elaborate two algorithms to guide GPs in the patient management for a first major depressive disorder (MDD) or generalized anxiety disorder (GAD) episode in primary care. DATA SOURCES: PubMed, Cochrane, and ISI Web of Science were explored using mainly the following keywords: depressive disorder, anxiety disorders, antidepressive agents or antidepressant...
November 14, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29123931/rapid-ascending-sensorimotor-paralysis-hearing-loss-and-fatal-arrhythmia-in-a-multimorbid-patient-due-to-an-accidental-overdose-of-fluoxetine
#17
Matthew Herrmann, Prissilla Xu, Antonio Liu
Background: Common side effects of selective serotonin reuptake inhibitors (SSRIs) include tachycardia, drowsiness, tremor, nausea, and vomiting. Although SSRIs have less toxic side effects compared to more traditional antidepressants, serious and life threatening cases of SSRI overdose have been reported. We describe a 24-year-old multimorbid female who presented to the emergency department with rapid onset ascending sensorimotor paralysis, complicated by respiratory and cardiac arrest, found to have fatal levels of fluoxetine by toxicological analysis, not taken in a suicidal act...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29102768/brain-derived-neurotrophic-factor-bdnf-and-neurotrophin-3-nt3-levels-in-post-mortem-brain-tissue-from-patients-with-depression-compared-to-healthy-individuals%C3%A2-%C3%A2-a-proof-of-concept-study
#18
A Sheldrick, S Camara, M Ilieva, P Riederer, T M Michel
The neurotrophic factors (NTF) hypothesis of depression was postulated nearly a decade ago and is nowadays widely acknowledged. Previous reports suggest that cerebral concentrations of NTF may be reduced in suicide victims who received minimal or no antidepressant pharmacotherapy. Recent evidence suggests that antidepressant treatment may improve or normalise cerebral concentrations of neurotrophic factors. Therefore, we examined the concentration of brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) in different brain regions (cortex, cingulate gyrus, thalamus, hippocampus, putamen and nucleus caudatus) of 21 individuals - 7 patients of which 4 patients with major depressive disorder (MDD) and overall age 86...
October 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29099547/treating-pediatric-anxiety-initial-use-of-ssris-and-other-antianxiety-prescription-medications
#19
Greta A Bushnell, Scott N Compton, Stacie B Dusetzina, Bradley N Gaynes, M Alan Brookhart, John T Walkup, Moira A Rynn, Til Stürmer
OBJECTIVE: Multiple pharmacotherapies for treating anxiety disorders exist, including selective serotonin reuptake inhibitors (SSRIs), the recommended first-line pharmacotherapy for pediatric anxiety. We sought to describe initial antianxiety medication use in children and estimate how long antianxiety medications were continued. METHODS: In a large commercial claims database, we identified children (3-17 years) initiating prescription antianxiety medication from 2004 to 2014 with a recent anxiety diagnosis (ICD-9-CM = 293...
October 31, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29065916/a-randomised-controlled-trial-assessing-the-severity-and-duration-of-depressive-symptoms-associated-with-a-clinically-significant-response-to-sertraline-versus-placebo-in-people-presenting-to-primary-care-with-depression-panda-trial-study-protocol-for-a-randomised
#20
George Salaminios, Larisa Duffy, Anthony Ades, Ricardo Araya, Katherine S Button, Rachel Churchill, Tim Croudace, Catherine Derrick, Padraig Dixon, Christopher Dowrick, Simon Gilbody, William Hollingworth, Vivien Jones, Tony Kendrick, David Kessler, Daphne Kounali, Paul Lanham, Alice Malpass, Tim J Peters, Derek Riozzie, Jude Robinson, Debbie Sharp, Laura Thomas, Nicky J Welton, Nicola Wiles, Glyn Lewis
BACKGROUND: Depressive symptoms are usually managed within primary care and antidepressant medication constitutes the first-line treatment. It remains unclear at present which people are more likely to benefit from antidepressant medication. This paper describes the protocol for a randomised controlled trial (PANDA) to investigate the severity and duration of depressive symptoms that are associated with a clinically significant response to sertraline compared to placebo, in people presenting to primary care with depression...
October 24, 2017: Trials
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