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https://www.readbyqxmd.com/read/28806612/pilots-using-selective-serotonin-reuptake-inhibitors-compared-to-other-fatally-injured-pilots
#1
Paul Rogers, Christy Hileman, Guillermo Salazar, Kacey Cliburn, Lawrence Paskoff, William Hathaway, Kevin Gildea, Victor Hugo Tejera Villalaz
Selective Serotonin Reuptake Inhibitors (SSRI) were a disqualifying medication for U.S. civil pilots before April 5, 2010. After this date, a Federal Aviation Administration policy was created that allowed airmen, on select SSRIs, a pathway to hold a valid medical certificate. The purpose of this study was to provide a detailed look at SSRIs in the U.S. pilot population since the inception of this new policy. We examined the toxicology results from fatally injured airmen in addition to outcomes concerning pilots who are participating in the program...
August 11, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28791695/use-of-antidepressants-and-risk-of-epithelial-ovarian-cancer
#2
Lina S Mørch, Christian Dehlendorff, Louise Baandrup, Søren Friis, Susanne K Kjaer
Antidepressants are widely prescribed among women to treat depression and anxiety disorders, but studies of their effects on gynecological cancer risk are sparse. We assessed associations between various antidepressants and risk of epithelial ovarian cancer. By using Danish nationwide registers, we identified all women (cases) aged 30 to 84 years with incident epithelial (serous, endometrioid, clear cell or mucinous) ovarian cancer during 2000-2011 (n= 4,103) and matched each case to 20 population controls (n=58,706) by risk-set matching...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28765248/adherence-and-persistence-with-drug-therapy-among-fibromyalgia-patients-data-from-a-large-health-maintenance-organization
#3
Dana Ben-Ami Shor, Dahlia Weitzman, Shani Dahan, Omer Gendelman, Yael Bar-On, Daniela Amital, Varda Shalev, Gabriel Chodick, Howard Amital
OBJECTIVE: To assess 1-year persistence and adherence rates with drug therapy among patients with fibromyalgia (FM) and to identify factors associated with therapy discontinuation. METHODS: This retrospective, cohort study included members ≥ 21 years old from the Maccabi Healthcare Services, a large health maintenance organization in Israel, who were diagnosed with FM from 2008 through 2011. Medications of interest included the anticonvulsant pregabalin, antidepressants [selective serotonin reuptake inhibitor (SSRI), serotonin/norepinephrine reuptake inhibitor (SNRI)], and tricyclic antidepressants (TCA)...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28759400/body-composition-in-adolescents-during-treatment-with-selective-serotonin-reuptake-inhibitors
#4
Chadi A Calarge, James A Mills, Kathleen F Janz, Trudy L Burns, William H Coryell, Babette S Zemel
OBJECTIVES: To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents. METHODS: Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Body Mass Index (BMI) was measured every 4 months...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28735693/concomitant-use-of-atypical-antipsychotics-with-other-psychotropic-medication-classes-and-the-risk-of-type-2-diabetes-mellitus
#5
Mehmet Burcu, Julie M Zito, Daniel J Safer, Laurence S Magder, Susan dosReis, Fadia T Shaya, Geoffrey L Rosenthal
OBJECTIVE: More than half of youth treated with atypical antipsychotic (AAP) medications are also treated with concomitant antidepressants or stimulants. This study assessed the association between antidepressant or stimulant use concomitant with AAPs and the risk of incident type 2 diabetes mellitus (T2DM). METHOD: Medicaid Analytic eXtract data were used to conduct a retrospective cohort study of youth (aged 5-20 years) who initiated AAP treatment. In AAP-treated youth, concomitant antidepressant (selective serotonin reuptake inhibitors [SSRI]/serotonin-norepinephrine reuptake inhibitors [SNRIs], tricyclic/other cyclic antidepressants [TCAs], and other antidepressants) or stimulant use was assessed...
August 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28735226/perinatal-fluoxetine-effects-on-social-play-the-hpa-system-and-hippocampal-plasticity-in-pre-adolescent-male-and-female-rats-interactions-with-pre-gestational-maternal-stress
#6
Mary Gemmel, Mariah Hazlett, Eszter Bögi, Sonsoles De Lacalle, Lesley A Hill, Nikolaos Kokras, Geoffrey L Hammond, Christina Dalla, Thierry D Charlier, Jodi L Pawluski
Selective serotonin reuptake inhibitor medications (SSRIs) are the first lines of treatment for maternal affective disorders, and are prescribed to up to 10% of pregnant women. Concern has been raised about how perinatal exposure to these medications affect offspring neurobehavioral outcomes, particularly those related to social interactions, as recent research has reported conflicting results related to autism spectrum disorder (ASD) risk in children prenatally exposed to SSRIs. Therefore, the aim of this work was to investigate the effects of perinatal exposure to the SSRI fluoxetine on social play behaviors and the hypothalamic pituitary adrenal system, using a model of pre-gestational maternal stress...
July 15, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28728805/associations-of-c-reactive-protein-and-psychological-distress-are-modified-by-antidepressants-supporting-an-inflammatory-depression-subtype-findings-from-ukhls
#7
Amanda Hughes, Meena Kumari
BACKGROUND: Clinical evidence increasingly suggests inflammation may be important specifically for an etiologically distinct depression subtype, characterised by resistance to antidepressant medication. However, epidemiological investigations of the relationship of inflammation with depression and psychological distress have failed to acknowledge these developments, which may have resulted in bias or masking of associations driven by the subtype. This may have contributed to inconsistent results in epidemiological studies, and equivocal support for an inflammation-depression link...
July 17, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28714603/variations-in-neurodevelopmental-outcomes-in-children-with-prenatal-ssri-antidepressant-exposure
#8
REVIEW
Naama Rotem-Kohavi, Tim F Oberlander
Mood disorders and treatment with selective serotonin reuptake inhibitor (SSRI) antidepressants during pregnancy are common and both pose neurodevelopmental risks. This often makes the decision to treat prenatal depression with pharmacotherapy (i.e., antidepressants) challenging for clinicians and mothers. SSRIs block the reuptake of the neurotransmitter serotonin (5HT) and given its developmental role, it is not inconceivable that early changes in 5HT signaling could have an impact on early brain development...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28713436/the-traditional-chinese-medicine-and-relevant-treatment-for-the-efficacy-and-safety-of-atopic-dermatitis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
Zhao-Feng Shi, Tie-Bing Song, Juan Xie, Yi-Quan Yan, Yong-Ping Du
BACKGROUND: Atopic dermatitis (AD) has become a common skin disease that requires systematic and comprehensive treatment to achieve adequate clinical control. Traditional Chinese medicines and related treatments have shown clinical effects for AD in many studies. But the systematic reviews and meta-analyses for them are lacking. OBJECTIVE: The systematic review and meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement were conducted to evaluate the efficacy and safety of traditional Chinese medicines and related treatments for AD treatment...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28712980/association-of-selective-serotonin-reuptake-inhibitors-and-bone-mineral-density-in-elderly-women
#10
Smita Saraykar, Vineeth John, Bo Cao, Matthew Hnatow, Catherine G Ambrose, Nahid Rianon
Depression and osteoporosis are 2 common comorbidities in geriatric patients. There are concerns about the deleterious effects of selective serotonin reuptake inhibitor (SSRI) antidepressant use on bone mineral density (BMD). We examined the association between SSRI use and BMD in elderly women (≥65 yr) referred to a geriatric osteoporosis clinic for bone health evaluation. Cross-sectional analyses using the general linear model were performed on data collected retrospectively from August 2010 to April 2015...
July 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28700807/association-of-antidepressant-medication-use-during-pregnancy-with-intellectual-disability-in-offspring
#11
Alexander Viktorin, Rudolf Uher, Alexander Kolevzon, Abraham Reichenberg, Stephen Z Levine, Sven Sandin
Importance: Maternal antidepressant medication use during pregnancy has previously been associated with adverse outcomes in offspring, but to our knowledge, the association with intellectual disability (ID) has not been investigated. Objectives: To examine the association of maternal antidepressant medication use during pregnancy with ID in offspring and investigate the importance of parental mental illness for such an association. Design, Setting, and Participants: A population-based cohort study of 179 007 children born from January 1, 2006, through December 31, 2007, with complete parental information from national registers who were followed up from birth throughout 2014...
July 12, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28698115/interleukin-17-selectively-predicts-better-outcomes-with-bupropion-ssri-combination-novel-t-cell-biomarker-for-antidepressant-medication-selection
#12
Manish K Jha, Abu Minhajuddin, Bharathi Gadad, Tracy L Greer, Taryn L Mayes, Madhukar H Trivedi
BACKGROUND: Interleukin 17 (IL-17) is produced by highly inflammatory Th17 cells and has been implicated in pathophysiology of depression. IL-17 putatively disrupts the blood brain barrier and affects dopamine synthesis whereas dopamine has been shown to decrease Th17 cell-mediated immune response. Nevertheless, whether IL-17 can predict differential treatment outcome with antidepressants modulating dopaminergic transmission is unknown. METHODS: IL-17 and other T cell and non-T cell markers (Th1, Th2 and non-T cell markers) were measured with the Bioplex Pro™ human cytokine 27-plex kit in the Combining Medications to Enhance Depression Outcomes (CO-MED) trial participants who provided baseline plasma and were treated with either bupropion plus escitalopram (bupropion-SSRI), escitalopram plus placebo (SSRI monotherapy), or venlafaxine plus mirtazapine (n=166)...
July 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28672405/driving-performance-of-depressed-patients-who-are-untreated-or-receive-long-term-antidepressant-ssri-snri-treatment
#13
Nick N J J M van der Sluiszen, Marleen Wingen, Annemiek Vermeeren, Frederick Vinckenbosch, Stefan Jongen, Johannes G Ramaekers
Introduction Depression is a mental disorder likely to affect everyday functions. The present study aimed to assess actual driving performance of depressed patients who were without specific antidepressant treatment or received long-term antidepressant treatment. Methods A standardized on-the-road driving test was used to assess standard deviation of lateral position (SDLP) in 3 patient groups receiving either no antidepressant treatment (with or without benzodiazepine medication) or treatment with selective serotonin/noradrenalin reuptake inhibitors for a period of 6-52 weeks...
July 3, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28656371/cerebrospinal-fluid-monoamine-metabolite-profiles-in-bipolar-disorder-adhd-and-controls
#14
Erik Pålsson, Carl Sellgren, Eleonore Rydén, Ruth Kizza, Aurimantas Pelanis, Henrik Zetterberg, Kaj Blennow, Mikael Landén
Alterations in monoaminergic signaling are suggested as key aspects of the pathophysiology in bipolar disorder and ADHD, but it is not known if the monoamine metabolic profile differs between these disorders. One method to study monoaminergic systems in humans is to measure monoamine end-point metabolite concentrations in cerebrospinal fluid (CSF). Here, we analyzed CSF monoamine metabolite concentrations in 103 adults with bipolar disorder, 72 adults with ADHD, and 113 controls. Individuals with bipolar disorder had significantly higher homovanillic acid (HVA, 264 ± 112 nmol/L, p < 0...
June 27, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28646789/data-mining-for-detecting-signals-of-adverse-drug-reactions-of-fluoxetine-using-the-korea-adverse-event-reporting-system-kaers-database
#15
Seonji Kim, Kyounghoon Park, Mi-Sook Kim, Bo Ram Yang, Hyun Jin Choi, Byung-Joo Park
Selective serotonin reuptake inhibitors (SSRIs) have become one of the most broadly used medications in psychiatry. Fluoxetine is the first representative antidepressant SSRI drug approved by the Food and Drug Administration (FDA) in 1987. Safety information on fluoxetine use alone was less reported than its combined use with other drugs. There were no published papers on adverse drug reactions (ADRs) of fluoxetine analyzing spontaneous adverse events reports. We detected signals of the adverse drug reactions of fluoxetine by data mining using the Korea Adverse Events Reporting System (KAERS) database...
June 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28644344/treatment-of-functional-abdominal-pain-with-antidepressants-benefits-adverse-effects-and-the-gastroenterologist-s-role
#16
Claire A M Zar-Kessler, Jaime Belkind-Gerson, Suzanne Bender, Braden M Kuo
OBJECTIVES: Pediatric functional abdominal pain is often treated with tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). The aim is investigating antidepressant use for treatment efficacy, correlation of response to psychiatric factors, and impact of adverse effects in regard to physicians' prescribing patterns. METHODS: Retrospective review (2005-2013) children (5-21 years old) with functional abdominal pain treated with SSRI or TCA...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28642048/sexual-consequences-of-post-ssri-syndrome
#17
REVIEW
Yacov Reisman
INTRODUCTION: Sexual dysfunctions are well-known side effects of selective serotonin reuptake inhibitor (SSRI) use. Altered libido, erectile dysfunction, vaginal dryness, ejaculatory disorders, and orgasmic problems are frequently reported by patients treated with SSRIs. Moreover, these antidepressant-emergent sexual dysfunctions do not always resolve after discontinuation of the medication and can persist indefinitely. These complaints are termed post-SSRI sexual dysfunctions (PSSD)...
June 19, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28640459/antidepressant-use-in-pregnancy-and-the-risk-of-attention-deficit-with-or-without-hyperactivity-disorder-in-children
#18
Takoua Boukhris, Odile Sheehy, Anick Bérard
BACKGROUND: The association between antidepressant (AD) use during pregnancy and the risk of attention deficit with or without hyperactivity disorder (ADHD) in children is debated. We investigated the risk of ADHD associated with overall and class-specific antidepressant exposure in utero. METHODS: We designed a register-based cohort study using the Quebec Pregnancy/Children Cohort (QPC). A total of 144 406 singleton full-term live-born from 1998 to 2009 were included...
June 22, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28623894/-doing-the-right-thing-factors-influencing-gp-prescribing-of-antidepressants-and-prescribed-doses
#19
Chris F Johnson, Brian Williams, Stephen A MacGillivray, Nadine J Dougall, Margaret Maxwell
BACKGROUND: Antidepressant prescribing continues to increase, with 5-16% of adults receiving antidepressants annually. Total prescribing growth is due in part to increased long-term use, greater selective serotonin re-uptake inhibitor (SSRI) use and the use of higher SSRI doses. Evidence does not support routine use of higher SSRI doses for depression treatment, and factors influencing the use of such doses are not well known. The aim of this study was to explore factors influencing GPs' use of antidepressants and their doses to treat depression...
June 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28608626/serotonergic-5httlpr-rs25531-s-allele-homozygosity-associates-with-violent-suicides-in-male-citalopram-users
#20
Anna-Liina Rahikainen, Salla Majaharju, Jari Haukka, Jukka U Palo, Antti Sajantila
Depressive disorders are involved as a background factor in over 50% of suicide cases. The most widely used antidepressants today are serotonin selective reuptake inhibitors (SSRIs). However, not all users benefit from SSRI medication. Although the overall number of suicides in Finland have decreased notably during the last decade, the annual rate is still relatively high, particularly in male population. In this study, we tested the hypothesis that the genetic variants associated with decreased citalopram efficiency, 5HTTLPR/rs25531, and increased impulsive behavior, MAOA-uVNTR and HTR2B Q20*, are more frequent among citalopram users committing suicide than among the citalopram users in general...
June 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
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