keyword
https://read.qxmd.com/read/38490565/the-impact-of-prenatal-alcohol-synthetic-cannabinoid-and-co-exposure-on-behavioral-adaptations-in-adolescent-offspring-and-alcohol-self-administration-in-adulthood
#1
JOURNAL ARTICLE
Laura C Ornelas, Eric W Fish, Jacob C Dooley, Megan Carroll, Scott E Parnell, Joyce Besheer
Prenatal exposure to alcohol or cannabinoids can produce enduring neurobiological, cognitive, and behavioral changes in the offspring. Furthermore, prenatal co-exposure to alcohol and cannabinoids induces malformations in brain regions associated with reward and stress-related circuitry. This study examined the effects of co-exposure to alcohol and the synthetic cannabinoid (SCB) CP55,940 throughout gastrulation and neurulation in rats on basal corticosterone levels and a battery of behavioral tests during adolescence and alcohol self-administration in adulthood...
March 13, 2024: Neurotoxicology and Teratology
https://read.qxmd.com/read/38474425/overactivation-of-the-endocannabinoid-system-in-adolescence-disrupts-adult-adipose-organ-function-in-mice
#2
JOURNAL ARTICLE
Kwang-Mook Jung, Lin Lin, Daniele Piomelli
Cannabis use stimulates calorie intake, but epidemiological studies show that people who regularly use it are leaner than those who don't. Two explanations have been proposed for this paradoxical finding. One posits that Δ9 -tetrahydrocannabinol (THC) in cannabis desensitizes adipose CB1 cannabinoid receptors, stopping their stimulating effects on lipogenesis and adipogenesis. Another explanation is that THC exposure in adolescence, when habitual cannabis use typically starts, produces lasting changes in the developing adipose organ, which impacts adult systemic energy use...
March 6, 2024: Cells
https://read.qxmd.com/read/38461611/a-case-report-of-lai-two-injection-start-in-a-16-year-old-adolescent-with-severe-manic-episode-and-comorbid-cannabinoid-use-disorder
#3
JOURNAL ARTICLE
Laura Orsolini, Sofia Pacini Biagiotti, Lorenzo Maria Martino, Umberto Volpe
There is a lack of randomized clinical trials and few studies regarding long-acting injectable antipsychotics (LAIs) in adolescents. Non-adherence, aggressiveness, comorbid substance use disorder and lack of insight may represent the main reasons for starting LAIs. Hereby we describe a 16-year-old male adolescent subject with bipolar type I disorder and comorbid cannabinoid use disorder, successfully treated with two-injection start regimen of LAI aripiprazole. Two-injection start regime of aripiprazole could represent an effective and safe therapeutic option for adolescents with early onset bipolar disorder...
March 4, 2024: Asian Journal of Psychiatry
https://read.qxmd.com/read/38404644/-in-silico-analyses-of-the-involvement-of-gpr55-cb1r-and-trpv1-response-to-thc-contribution-to-temporal-lobe-epilepsy-structural-modeling-and-updated-evolution
#4
JOURNAL ARTICLE
Amy L Cherry, Michael J Wheeler, Karolina Mathisova, Mathieu Di Miceli
INTRODUCTION: The endocannabinoid (eCB) system is named after the discovery that endogenous cannabinoids bind to the same receptors as the phytochemical compounds found in Cannabis. While endogenous cannabinoids include anandamide (AEA) and 2-arachidonoylglycerol (2-AG), exogenous phytocannabinoids include Δ-9 tetrahydrocannabinol (THC) and cannabidiol (CBD). These compounds finely tune neurotransmission following synapse activation, via retrograde signaling that activates cannabinoid receptor 1 (CB1R) and/or transient receptor potential cation channel subfamily V member 1 (TRPV1)...
2024: Frontiers in Neuroinformatics
https://read.qxmd.com/read/38399295/unveiling-the-potential-of-cannabinoids-in-multiple-sclerosis-and-the-dawn-of-nano-cannabinoid-medicine
#5
REVIEW
Roua A Nouh, Ahmed Kamal, Oluwaseyi Oyewole, Walaa A Abbas, Bishoy Abib, Abdelrouf Omar, Somaia T Mansour, Anwar Abdelnaser
Multiple sclerosis is the predominant autoimmune disorder affecting the central nervous system in adolescents and adults. Specific treatments are categorized as disease-modifying, whereas others are symptomatic treatments to alleviate painful symptoms. Currently, no singular conventional therapy is universally effective for all patients across all stages of the illness. Nevertheless, cannabinoids exhibit significant promise in their capacity for neuroprotection, anti-inflammation, and immunosuppression. This review will examine the traditional treatment for multiple sclerosis, the increasing interest in using cannabis as a treatment method, its role in protecting the nervous system and regulating the immune system, commercially available therapeutic cannabinoids, and the emerging use of cannabis in nanomedicine...
February 7, 2024: Pharmaceutics
https://read.qxmd.com/read/38397346/the-use-of-cannabinoids-in-pediatric-palliative-care-a-retrospective-single-center-analysis
#6
JOURNAL ARTICLE
David Tagsold, Irmgard Toni, Regina Trollmann, Joachim Woelfle, Chara Gravou-Apostolatou
This data analysis aimed to systematically analyze a pediatric patient population with a life-limiting disease who were administered cannabinoids. It was a retrospective single-center analysis of patients under supervision of the specialized outpatient pediatric palliative care (SOPPC) team at the Department of Pediatrics and Adolescent Medicine of the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU). Thirty-one patients with a primary diagnosis of neuropediatric, oncologic, metabolic, and cardiologic categories were included...
February 11, 2024: Children
https://read.qxmd.com/read/38361722/neurocognitive-impact-of-exposure-to-cannabis-concentrates-and-cannabinoids-including-vaping-in-children-and-adolescents-a-systematic-review
#7
REVIEW
Michell S Saavedra, Priyanka Thota, Tariladei S Peresuodei, Abhishek Gill, Chijioke Orji, Maiss Reghefaoui, Safeera Khan
During adolescence, significant changes unfold in the brain's maturation process. The density of white matter increases, accompanied by the pruning back of gray matter. This critical and vulnerable period becomes especially noteworthy in the context of drug use, as adolescents are extensively exposed to substances such as tobacco, alcohol, and cannabis. The concern is heightened now that cannabis has been legalized for recreational use in many places, leading to increased exposure levels. Additionally, knowledge about the impact of cannabis on neurocognitive development during this stage is limited...
January 2024: Curēus
https://read.qxmd.com/read/38314698/limited-wky-chromosomal-regions-confer-increases-in-anxiety-and-fear-memory-in-a-f344-congenic-rat-strain
#8
JOURNAL ARTICLE
Michelle T Ji, Neha Pashankar, Aspen M Harter, Mariya Nemesh, Katherine J Przybyl, Megan K Mulligan, Hao Chen, Eva E Redei
This study investigated the interaction between genetic differences in stress reactivity/coping and environmental challenge, such as acute stress during adolescence on adult contextual fear memory and anxiety-like behaviors. Fischer 344 (F344) and the inbred F344;WKY-Stresp3/Eer congenic strain (congenic), in which chromosomal regions from the Wistar Kyoto (WKY) strain were introgressed into the F344 background, were exposed to a modified Forced Swim Test (FST) during adolescence while controls were undisturbed...
February 5, 2024: Physiological Genomics
https://read.qxmd.com/read/38309382/novel-rapid-treatment-options-for-adolescent-depression
#9
JOURNAL ARTICLE
Sandra Ledesma-Corvi, Jordi Jornet-Plaza, Laura Gálvez-Melero, M Julia García-Fuster
There is an urgent need for novel fast-acting antidepressants for adolescent treatment-resistant depression and/or suicidal risk, since the selective serotonin reuptake inhibitors that are clinically approved for that age (i.e., fluoxetine or escitalopram) take weeks to work. In this context, one of the main research lines of our group is to characterize at the preclinical level novel approaches for rapid-acting antidepressants for adolescence. The present review summarizes the potential use in adolescence of non-pharmacological options, such as neuromodulators (electroconvulsive therapy and other innovative types of brain stimulation), as well as pharmacological options, including consciousness-altering drugs (mainly ketamine but also classical psychedelics) and cannabinoids (i...
February 2, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38190273/sex-differences-in-response-contingent-cannabis-vapor-administration-during-adolescence-mediate-enduring-effects-on-behavioral-flexibility-and-prefrontal-microglia-activation-in-rats
#10
JOURNAL ARTICLE
Timothy G Freels, Sara R Westbrook, Erica Zamberletti, Jacqulyn R Kuyat, Hayden R Wright, Alexandra N Malena, Max W Melville, Amanda M Brown, Nicholas C Glodosky, Darren E Ginder, Courtney M Klappenbach, Kristen M Delevich, Tiziana Rubino, Ryan J McLaughlin
Introduction: Cannabis is the most used illicit drug in the United States. With many states passing legislation to permit its recreational use, there is concern that cannabis use among adolescents could increase dramatically in the coming years. Historically, it has been difficult to model real-world cannabis use to investigate the causal relationship between cannabis use in adolescence and behavioral and neurobiological effects in adulthood. Materials and Methods: We used a response-contingent vapor administration model to investigate long-term effects of cannabis use during adolescence on the medial prefrontal cortex (mPFC) and mPFC-dependent behaviors in male and female rats...
January 8, 2024: Cannabis and Cannabinoid Research
https://read.qxmd.com/read/38139145/omega-3-recovers-cannabinoid-1-receptor-expression-in-the-adult-mouse-brain-after-adolescent-binge-drinking
#11
JOURNAL ARTICLE
Ane Martín-Llorente, Maitane Serrano, Itziar Bonilla-Del Río, Leire Lekunberri, Garazi Ocerin, Nagore Puente, Almudena Ramos, Irantzu Rico-Barrio, Inmaculada Gerrikagoitia, Pedro Grandes
Adolescent binge drinking is a social problem with a long-lasting impact on cognitive functions. The cannabinoid type-1 (CB1 ) receptor of the endocannabinoid system (ECS) is involved in brain synaptic plasticity, cognition and behavior via receptor localization at specific subcellular compartments of the cortical, limbic and motor regions. Alcohol (EtOH) intake affects the ECS, CB1 and their functions. Evidence indicates that binge drinking during adolescence impairs memory via the abrogation of CB1 -dependent synaptic plasticity in the hippocampus...
December 10, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38134471/a-comprehensive-lc-ms-ms-method-for-simultaneous-analysis-of-65-synthetic-cannabinoids-in-human-hair-samples-and-application-to-forensic-investigations
#12
JOURNAL ARTICLE
Yiqi Yang, Buyi Xu, Daoxia Li, Qifu Zhang, Jing Zhang, Lin Yang, Yi Ye
Synthetic cannabinoids (SCs) represent a diverse class of new psychoactive substances characterized by extensive substance variety and severe abuse implications. The current situation of synthetic cannabinoid abuse in China is getting worse, with an increasing number of SC variants emerging. Therefore, it is imperative to improve synthetic cannabinoid detecting methods to align with the prevalent abuse situation in the region. In this study, a reliable and validated liquid chromatography-tandem mass spectrometry method was developed for the qualitative and quantitative analysis of 65 SC analogues in human hair samples...
December 15, 2023: Journal of Forensic and Legal Medicine
https://read.qxmd.com/read/38124000/cannabinoid-home-storage-practices-among-a-national-qualtrics-panel-of-adult-users-of-cannabinoid-products-in-the-usa
#13
JOURNAL ARTICLE
Kathleen Louise Egan, Melissa J Cox
INTRODUCTION: The presence of cannabinoid products in the home may increase the likelihood of unintended adverse consequences for children and adolescents. Secure storage of these products is one prevention method to decrease the risk of diversion and use of cannabinoid products among youth. We sought to examine cannabis, delta-8 tetrahydrocannabinol (THC), and cannabidiol (CBD) storage practices among a sample of adults 18-64 years old residing in the USA. METHODS: In December 2021, we conducted an online cross-sectional survey of 1042 current (past 30 day) users of cannabinoid products (88...
December 16, 2023: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://read.qxmd.com/read/38099278/gene-expression-changes-in-the-cerebellum-are-associated-with-persistent-post-injury-pain-in-adolescent-rats-exposed-to-early-life-stress
#14
JOURNAL ARTICLE
Sabrina Salberg, Crystal N Li, Jaimie K Beveridge, Melanie Noel, Glenn R Yamakawa, Richelle Mychasiuk
Chronic pain develops following injury in approximately 20% of adolescents, at twice the rate in females than males. Adverse childhood experiences also increase the risk for poor health outcomes, such as chronic pain. Emerging literature suggests the cerebellum to be involved in pain processing, however detailed explorations into how the cerebellum contributes to pain are lacking. Therefore, this study aimed to characterise chronic pain outcomes and cerebellar gene expression changes following early life stress and injury in both sexes...
2023: Neurobiology of Pain
https://read.qxmd.com/read/38091780/cannabis-use-and-neurocognitive-performance-at-13-14-years-old-optimizing-assessment-with-hair-toxicology-in-the-adolescent-brain-cognitive-development-abcd-study
#15
JOURNAL ARTICLE
Natasha E Wade, Alexander L Wallace, Marilyn A Huestis, Krista M Lisdahl, Ryan M Sullivan, Susan F Tapert
OBJECTIVE: Cannabis is widely used, including in early adolescence, with prevalence rates varying by measurement method (e.g., toxicology vs. self-report). Critical neurocognitive development occurs throughout adolescence. Given conflicting prior brain-behavior results in cannabis research, improved measurement of cannabis use in younger adolescents is needed. METHODS: Data from the Adolescent Brain Cognitive Development (ABCD) Study Year 4 follow-up (participant age: 13-14 years-old) included hair samples assessed by LC-MS/MS and GC-MS/MS, quantifying THCCOOH (THC metabolite), THC, and cannabidiol concentrations, and the NIH Toolbox Cognitive Battery...
December 2, 2023: Addictive Behaviors
https://read.qxmd.com/read/38069051/molecular-changes-associated-with-suicide
#16
REVIEW
Daniela Navarro, Marta Marín-Mayor, Ani Gasparyan, María Salud García-Gutiérrez, Gabriel Rubio, Jorge Manzanares
Suicide is a serious global public health problem, with a worrying recent increase in suicide rates in both adolescent and adult populations. However, it is essential to recognize that suicide is preventable. A myriad of factors contributes to an individual's vulnerability to suicide. These factors include various potential causes, from psychiatric disorders to genetic and epigenetic alterations. These changes can induce dysfunctions in crucial systems such as the serotonergic, cannabinoid, and hypothalamic-pituitary-adrenal axes...
November 24, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38064909/thc-improves-behavioural-schizophrenia-like-deficits-that-cbd-fails-to-overcome-a-comprehensive-multilevel-approach-using-the-poly-i-c-maternal-immune-activation
#17
JOURNAL ARTICLE
Nicolás Lamanna-Rama, Diego Romero-Miguel, Marta Casquero-Veiga, Karina S MacDowell, Cristina Santa-Marta, Sonia Torres-Sánchez, Esther Berrocoso, Juan C Leza, Manuel Desco, María Luisa Soto-Montenegro
Prenatal infections and cannabis use during adolescence are well-recognized risk factors for schizophrenia. As inflammation and oxidative stress (OS) contribute to this disorder, anti-inflammatory drugs have been proposed as potential therapies. This study aimed to evaluate the association between delta-9-tetrahydrocannabinol (THC) and schizophrenia-like abnormalities in a maternal immune activation (MIA) model. Additionally, we assessed the preventive effect of cannabidiol (CBD), a non-psychotropic/anti-inflammatory cannabinoid...
November 27, 2023: Psychiatry Research
https://read.qxmd.com/read/38021250/the-first-hit-to-the-endocannabinoid-system-associations-between-prenatal-cannabis-exposure-and-frontolimbic-white-matter-pathways-in-children
#18
JOURNAL ARTICLE
Julia M Evanski, Clara G Zundel, Samantha L Baglot, Shreya Desai, Leah C Gowatch, Samantha L Ely, Nareen Sadik, Leslie H Lundahl, Matthew N Hill, Hilary A Marusak
BACKGROUND: Cannabis is the most used federally illicit substance among pregnant people in the United States. However, emerging preclinical data show that a significant portion of cannabis constituents, such as Δ9 -tetrahydrocannabinol and its bioactive metabolites, readily cross the placenta and accumulate in the fetal brain, disrupting neurodevelopment. Recent research using the Adolescent Brain Cognitive Development (ABCD) Study cohort has linked prenatal cannabis exposure (PCE) to greater neurobehavioral problems and lower total gray and white matter volume in children...
January 2024: Biol Psychiatry Glob Open Sci
https://read.qxmd.com/read/38020805/%C3%AE-9-tetrahydrocannabinol-does-not-upregulate-an-aversive-dopamine-receptor-mechanism-in-adolescent-brain-unlike-in-adults
#19
JOURNAL ARTICLE
Marie-Eve Di Raddo, Marija Milenkovic, Meenalochani Sivasubramanian, Ahmed Hasbi, Jack Bergman, Sarah Withey, Bertha K Madras, Susan R George
Earlier age of cannabis usage poses higher risk of Cannabis Use Disorder and adverse consequences, such as addiction, anxiety, dysphoria, psychosis, largely attributed to its principal psychoactive component, Δ9-tetrahydrocannabinol (THC) and altered dopaminergic function. As dopamine D1-D2 receptor heteromer activation causes anxiety and anhedonia, this signaling complex was postulated to contribute to THC-induced affective symptoms. To investigate this, we administered THC repeatedly to adolescent monkeys and adolescent or adult rats...
2023: Current research in neurobiology
https://read.qxmd.com/read/38010707/false-negative-confirmatory-testing-in-patients-with-cannabinoid-positive-urine-drug-screens
#20
JOURNAL ARTICLE
C James Watson, Gwendolyn A McMillin, Michele M Burns
No abstract text is available yet for this article.
November 27, 2023: JAMA Pediatrics
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