keyword
https://read.qxmd.com/read/35740018/focus-on-the-contribution-of-oxidative-stress-in-skin-aging
#21
REVIEW
Federica Papaccio, Andrea D Arino, Silvia Caputo, Barbara Bellei
Skin aging is one of the most evident signs of human aging. Modification of the skin during the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity, rough-textured appearance, and pallor. In contrast, photoaged skin is associated with uneven pigmentation (age spot) and is markedly wrinkled. At the cellular and molecular level, it consists of multiple interconnected processes based on biochemical reactions, genetic programs, and occurrence of external stimulation. The principal cellular perturbation in the skin driving senescence is the alteration of oxidative balance...
June 6, 2022: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/35618649/absence-of-the-rpb9-subunit-of-rna-polymerase-ii-reduces-the-chronological-life-span-in-fission-yeast
#22
JOURNAL ARTICLE
Vaibhav Bhardwaj, Nimisha Sharma
Fission yeast RNA polymerase II consists of 12 subunits, Rpb1-Rpb12. Among these subunits, Rpb9 is the only subunit whose absence does not cause lethality under optimum growth conditions in fission yeast. However, an rpb9 null fission yeast mutant exhibits a slow-growth phenotype under optimum growth conditions and a defect in survival under environmental and genotoxic stress conditions. To further gain an understanding of its physiological roles, in the present study we have elucidated the role of the Rpb9 subunit in chronological aging using fission yeast as the model organism...
August 2022: Journal of Basic Microbiology
https://read.qxmd.com/read/35572140/structural-and-functional-trajectories-of-middle-temporal-gyrus-sub-regions-during-life-span-a-potential-biomarker-of-brain-development-and-aging
#23
JOURNAL ARTICLE
Jinping Xu, Jinhuan Zhang, Jiaying Li, Haoyu Wang, Jianxiang Chen, Hanqing Lyu, Qingmao Hu
Although previous studies identified a similar topography pattern of structural and functional delineations in human middle temporal gyrus (MTG) using healthy adults, trajectories of MTG sub-regions across lifespan remain largely unknown. Herein, we examined gray matter volume (GMV) and resting-state functional connectivity (RSFC) using datasets from the Nathan Kline Institute (NKI), and aimed to (1) investigate structural and functional trajectories of MTG sub-regions across the lifespan; and (2) assess whether these features can be used as biomarkers to predict individual's chronological age...
2022: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/35452476/the-safety-and-efficacy-of-fingolimod-real-world-data-from-a-long-term-non-interventional-study-on-the-treatment-of-rrms-patients-spanning-up-to-5-years-from-hungary
#24
JOURNAL ARTICLE
Tamás Biernacki, Dániel Sandi, Judit Füvesi, Zsanett Fricska-Nagy, Tamás Zsigmond Kincses, Péter Ács, Csilla Rózsa, Enikő Dobos, Botond Cseh, László Horváth, Zsuzsanna Nagy, Attila Csányi, Krisztina Kovács, Tünde Csépány, László Vécsei, Krisztina Bencsik
BACKGROUND: Fingolimod was approved and reimbursed by the healthcare provider in Hungary for the treatment of highly active relapsing-remitting multiple sclerosis (RRMS) in 2012. The present study aimed to assess the effectiveness, safety profile, and persistence to fingolimod in a real-life setting in Hungary in RRMS patients who were either therapy naïve before enrollment or have changed to fingolimod from another disease-modifying therapy (DMT) for any reason. METHODS: This cross-sectional, observational study with prospective data collection was performed nationwide at 21 sites across Hungary...
2022: PloS One
https://read.qxmd.com/read/35346580/motor-competence-across-the-life-span-a-cross-sectional-study-of-iranians-aged-5-to-85-years
#25
JOURNAL ARTICLE
P Shamsipour Dehkordi, L L Hardy, A Shams, F Sohrabi
OBJECTIVES: To measure motor competence among a representative sample of Iranians aged 5-85 years. DESIGN: Cross-sectional. METHODS: Motor competence was assessed quantitatively by the Test of Motor Competence; two fine motor skills (placing and building bricks) and two gross motor skills (heel-to-toe-walking and walking/running in slopes) to assess dynamic balance. Task scores were summed and transformed into standardized scores (z-scores)...
June 2022: Journal of Science and Medicine in Sport
https://read.qxmd.com/read/35323382/differential-effects-of-fundamental-and-longitudinal-life-history-trade-offs-on-delay-discounting-an-evolutionary-framework
#26
JOURNAL ARTICLE
Junsong Lu, Qi'an Lu, Lin Lu
We synthesized life history theory and the antagonistic pleiotropy hypothesis to form an integrative framework for understanding delay discounting (DD). We distinguished between fundamental and longitudinal life history trade-offs to explain individual and age differences of DD. Fundamental life history trade-offs are characterized by life history strategies (LHS), describing how individuals adjust reproductive timing according to childhood environments, while longitudinal life history trade-offs characterize how individuals make trade-offs between early- vs...
March 1, 2022: Behavioral Sciences
https://read.qxmd.com/read/35058551/oxidative-stress-alleviating-potential-of-galactan-exopolysaccharide-from-weissella-confusa-kr780676-in-yeast-model-system
#27
JOURNAL ARTICLE
Digambar Kavitake, Bhavana Veerabhadrappa, S J Sudharshan, Sujatha Kandasamy, Palanisamy Bruntha Devi, Madhu Dyavaiah, Prathapkumar Halady Shetty
In the present study, galactan exopolysaccharide (EPS) from Weissella confusa KR780676 was evaluated for its potential to alleviate oxidative stress using in vitro assays and in vivo studies in Saccharomyces cerevisiae (wild type) and its antioxidant (sod1∆, sod2∆, tsa1∆, cta2∆ and ctt1∆), anti-apoptotic (pep4∆ and fis1∆) and anti-aging (sod2∆, tsa1∆ and ctt1∆)) isogenic gene deletion mutants. Galactan exhibited strong DPPH and nitric oxide scavenging activity with an IC50 value of 450 and 138 µg/mL respectively...
January 20, 2022: Scientific Reports
https://read.qxmd.com/read/34921163/screening-of-selected-ageing-related-proteins-that-extend-chronological-life-span-in-yeast-saccharomyces-cerevisiae
#28
JOURNAL ARTICLE
Jee Whu Lee, Tee Gee Ong, Mohammed Razip Samian, Aik-Hong Teh, Nobumoto Watanabe, Hiroyuki Osada, Eugene Boon Beng Ong
Ageing-related proteins play various roles such as regulating cellular ageing, countering oxidative stress, and modulating signal transduction pathways amongst many others. Hundreds of ageing-related proteins have been identified, however the functions of most of these ageing-related proteins are not known. Here, we report the identification of proteins that extended yeast chronological life span (CLS) from a screen of ageing-related proteins. Three of the CLS-extending proteins, Ptc4, Zwf1, and Sme1, contributed to an overall higher survival percentage and shorter doubling time of yeast growth compared to the control...
December 17, 2021: Scientific Reports
https://read.qxmd.com/read/34915111/a-short-social-interaction-between-adult-and-old-mice-improves-the-homeostatic-systems-and-increases-healthy-longevity
#29
JOURNAL ARTICLE
Estefanía Díaz-Del Cerro, Noemí Ceprián, Judith Félix, Mónica De la Fuente
The aging process can be influenced by environmental factors, such as the social environment. The continuous cohabitation of the chronologically old mice with adult animals improves them at the behavioral level, immune function, oxidative stress and longevity, but causes a deterioration of these parameters in adults. Therefore, the objective of the study was to study whether the coexistence for only 15 min a day of old mice with adult mice, can produce that improvement and greater longevity in old animals without causing deterioration in adults...
February 2022: Experimental Gerontology
https://read.qxmd.com/read/34875069/navigating-black-aging-the-biological-consequences-of-stress-and-depression
#30
JOURNAL ARTICLE
Sarah N Forrester, Keith E Whitfield, Catarina I Kiefe, Roland J Thorpe
OBJECTIVES: Black persons in the US are more likely to suffer from social inequality. Chronic stress caused by social inequality and racial discrimination results in weathering of the body that causes physiological dysregulation and biological age being higher than chronological age (accelerated aging). Depression has been linked to both racial discrimination and accelerated aging and accelerated aging has been demonstrated to be higher in Black than White persons, on average. However, we know little about accelerated aging across the life course in Black Americans...
December 7, 2021: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://read.qxmd.com/read/34869788/no-limit-to-maximal-lifespan-in-humans-how-to-beat-a-122-year-old-record
#31
JOURNAL ARTICLE
Mikhail V Blagosklonny
Although average human life expectancy is rising, the maximum lifespan is not increasing. Leading demographers claim that human lifespan is fixed at a natural limit around 122 years. However, there is no fixed limit in animals. In animals, anti-aging interventions (dietary restrictions, rapamycin, genetic manipulations) postpone age-related diseases and thus automatically extend maximum lifespan. In humans, anti-aging interventions have not been yet implemented. Instead, by treating individual diseases, medical interventions allow a patient to live longer (despite morbidity), expanding morbidity span...
2021: Oncoscience
https://read.qxmd.com/read/34844026/assessing-bone-maturity-compositional-and-mechanical-properties-of-rib-cortical-bone-at-different-ages
#32
JOURNAL ARTICLE
Andrea Bonicelli, Elena F Kranioti, Bledar Xhemali, Emily Arnold, Peter Zioupos
Understanding what maturity entails for bone, when it arrives, and its pre- and post-maturity traits and properties are very important for understanding its evolution and physiology. There is a clear but fine distinction between the chronological age of bone (the age of its donor) and the tissue age of the bone packets it comprises at the microscopic level. Whole bone fragility changes with age due to mass and architecture effects, but so do the properties of bone at the tissue level. Tissue age and tissue-level properties are therefore increasingly attracting a great deal of attention recently...
February 2022: Bone
https://read.qxmd.com/read/34840260/microvascular-ageing-links-metabolic-disease-to-age-related-disorders-the-role-of-oxidative-stress-and-inflammation-in-promoting-microvascular-dysfunction
#33
REVIEW
Alessandro Mengozzi, Nicola Riccardo Pugliese, Martina Chiriacò, Stefano Masi, Agostino Virdis, Stefano Taddei
Longer life span and increased prevalence of chronic, noncommunicable, inflammatory diseases fuel cardiovascular mortality. The microcirculation is central in the cross talk between ageing, inflammation, cardiovascular, and metabolic diseases. Microvascular dysfunction, characterized by alteration in the microvascular endothelial function and wall structure, is described in an increasing number of chronic age-associated diseases, suggesting that it might be a marker of ageing superior to chronological age. The aim of this review is to thoroughly explore the connections between microvascular dysfunction, ageing, and metabolic disorders by detailing the major role played by inflammation and oxidative stress in their evolution...
December 1, 2021: Journal of Cardiovascular Pharmacology
https://read.qxmd.com/read/34751669/ubb-1-reduces-amyloid-%C3%AE-cytotoxicity-by-activation-of-autophagy-in-yeast
#34
JOURNAL ARTICLE
Xin Chen, Ana Joyce Muñoz-Arellano, Dina Petranovic
UBB+1 is a mutated version of ubiquitin B peptide caused by a transcriptional frameshift due to the RNA polymerase II "slippage". The accumulation of UBB+1 has been linked to ubiquitin-proteasome system (UPS) dysfunction and neurodegeneration. Alzheimer's disease (AD) is defined as a progressive neurodegeneration and aggregation of amyloid-β peptides (Aβ) is a prominent neuropathological feature of AD. In our previous study, we found that yeast cells expressing UBB+1 at lower level display an increased resistance to cellular stresses under conditions of chronological aging...
November 9, 2021: Aging
https://read.qxmd.com/read/34685698/identification-of-tropical-plant-extracts-that-extend-yeast-chronological-life-span
#35
JOURNAL ARTICLE
Mandy Mun Yee Kwong, Jee Whu Lee, Mohammed Razip Samian, Habibah A Wahab, Nobumoto Watanabe, Eugene Boon Beng Ong
Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended chronological life span (CLS) in budding yeast from a screen of 222 PEs. We identified two PEs, the leaf extracts of Manihot esculenta and Wodyetia bifurcata that extended CLS in a dose-dependent manner...
October 11, 2021: Cells
https://read.qxmd.com/read/34114004/identification-of-sur2-mutation-affecting-the-lifespan-of-fission-yeast
#36
JOURNAL ARTICLE
Tatsuhiro Kurauchi, Kotaro Matsui, Takafumi Shimasaki, Hokuto Ohtsuka, Satoshi Tsubouchi, Kunio Ihara, Motohiro Tani, Hirofumi Aiba
Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2+ gene, which encodes a homolog of Saccharomyces cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological lifespan. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2+ gene...
June 24, 2021: FEMS Microbiology Letters
https://read.qxmd.com/read/33829847/subjective-age-from-childhood-to-advanced-old-age-a-meta-analysis
#37
JOURNAL ARTICLE
Martin Pinquart, Hans-Werner Wahl
The present meta-analysis analyzed how the gap between subjective age and chronological age changes across the life-span and whether the size of this gap varies across regions of the globe. In addition, we tested for sources of the national differences. A systematic search in electronic databases (PsycInfo, Medline, Google Scholar, PSYNDEX) and cross-referencing identified 294 studies (with mean age ranging from 8 to 105 years) that were included in random-effects meta-analyses. While children felt about 3 years or 34% older than their chronological age, older adults (60+ years) felt, on average, between 10...
May 2021: Psychology and Aging
https://read.qxmd.com/read/33605165/biological-aging-and-periodontal-disease-analysis-of-nhanes-2001-2002
#38
JOURNAL ARTICLE
L M Nguyen, J J Chon, E E Kim, J C Cheng, J L Ebersole
INTRODUCTION: Periodontitis is a chronic inflammatory disease caused by multiple potential contributing factors such as bacterial biofilm infection of the tissues surrounding the teeth and environmental determinants and a dysregulated host response for modifying and resolving the inflammation. Because periodontal disease is a major public health concern with substantial increases in the prevalence and severity in aging populations, previous studies of periodontitis tended to approach the disease as an age-associated outcome across the life span...
April 2022: JDR Clinical and Translational Research
https://read.qxmd.com/read/33549702/the-mapk-slt2-mpk1-plays-a-role-in-iron-homeostasis-through-direct-regulation-of-the-transcription-factor-aft1
#39
JOURNAL ARTICLE
Nuria Pujol-Carrion, Mónica Pavón-Vergés, Javier Arroyo, Maria Angeles de la Torre-Ruiz
Iron is an essential element for life. Cells develop mechanisms to tightly regulate its homeostasis, in order to avoid abnormal accumulation and the consequent cell toxicity. In budding yeast, the high affinity iron regulon is under the control of the transcription factor Aft1. We present evidence demonstrating that the MAPK Slt2 of the cell wall integrity pathway (CWI), phosphorylates and negatively regulates Aft1 activity upon the iron depletion signal, both in fermentative or respiratory conditions. The lack of Slt2 provokes Aft1 dysfunction leading to a shorter chronological life span...
April 2021: Biochimica et Biophysica Acta. Molecular Cell Research
https://read.qxmd.com/read/33536532/data-driven-identification-of-ageing-related-diseases-from-electronic-health-records
#40
JOURNAL ARTICLE
Valerie Kuan, Helen C Fraser, Melanie Hingorani, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Dorothea Nitsch, Rohini Mathur, Constantinos A Parisinos, R Thomas Lumbers, Reecha Sofat, Ian C K Wong, Juan P Casas, Janet M Thornton, Harry Hemingway, Linda Partridge, Aroon D Hingorani
Reducing the burden of late-life morbidity requires an understanding of the mechanisms of ageing-related diseases (ARDs), defined as diseases that accumulate with increasing age. This has been hampered by the lack of formal criteria to identify ARDs. Here, we present a framework to identify ARDs using two complementary methods consisting of unsupervised machine learning and actuarial techniques, which we applied to electronic health records (EHRs) from 3,009,048 individuals in England using primary care data from the Clinical Practice Research Datalink (CPRD) linked to the Hospital Episode Statistics admitted patient care dataset between 1 April 2010 and 31 March 2015 (mean age 49...
February 3, 2021: Scientific Reports
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