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https://www.readbyqxmd.com/read/29341456/iron-pill-aspiration-cytologic-and-histologic-findings-of-a-potential-life-threatening-airway-injury-a-case-report-and-literature-review
#1
Vanessa Henriques, Diogo Costa Santos, Graça Lérias, Lucília Cáceres Monteiro
Iron pill-induced injury of bronchial mucosa is a complication following accidental aspiration of an iron tablet. Oral iron supplementation is a common therapy, particularly among advanced-age patients, who are more prone to aspiration. However, iron pill aspiration has been rarely reported in the literature, usually under the format of short case reports, with only 32 cases published in the literature. The cytologic features suspicious for this rare but potentially lethal entity have been seldom described...
January 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29329306/lifespan-extension-without-fertility-reduction-following-dietary-addition-of-the-autophagy-activator-torin1-in-drosophila-melanogaster
#2
Janet S Mason, Tom Wileman, Tracey Chapman
Autophagy is a highly conserved mechanism for cellular repair that becomes progressively down-regulated during normal ageing. Hence, manipulations that activate autophagy could increase lifespan. Previous reports show that manipulations to the autophagy pathway can result in longevity extension in yeast, flies, worms and mammals. Under standard nutrition, autophagy is inhibited by the nutrient sensing kinase Target of Rapamycin (TOR). Therefore, manipulations of TOR that increase autophagy may offer a mechanism for extending lifespan...
2018: PloS One
https://www.readbyqxmd.com/read/29327956/the-incidence-and-treatment-outcomes-of-macrorhabdus-ornithogaster-infection-in-budgerigars-melopsittacus-undulatus-in-a-veterinary-clinic
#3
Ronja Püstow, Maria-Elisabeth Krautwald-Junghanns
Macrorhabdus ornithogaster, avian gastric yeast, is a common cause of gastrointestinal disease in budgerigars ( Melopsittacus undulatus). To better understand the clinical disease in budgerigars presented in a practice population, we reviewed the occurrence, clinical signs, and treatment success of M ornithogaster disease in budgerigars during a 2.5-year period at the Clinic for Birds and Reptiles, University of Leipzig (Leipzig, Germany). The yeast was diagnosed by microscopic examination of fresh fecal samples...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29324667/dietary-resveratrol-does-not-affect-life-span-body-composition-stress-response-and-longevity-related-gene-expression-in-drosophila-melanogaster
#4
Stefanie Staats, Anika E Wagner, Bianca Kowalewski, Florian T Rieck, Sebastian T Soukup, Sabine E Kulling, Gerald Rimbach
In this study, we tested the effect of the stilbene resveratrol on life span, body composition, locomotor activity, stress response, and the expression of genes encoding proteins centrally involved in ageing pathways in the model organism Drosophila melanogaster. Male and female w1118 D. melanogaster were fed diets based on sucrose, corn meal, and yeast. Flies either received a control diet or a diet supplemented with 500 µmol/L resveratrol. Dietary resveratrol did not affect mean, median, and maximal life span of male and female flies...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29319242/clinical-diversity-of-cns-cryptococcosis
#5
J M Koshy, S Mohan, D Deodhar, M John, A Oberoi, A Pannu
Background: Though cryptococcal meningitis (CM) is recognized as a disease of the immunocompromised, studies have implicated that it also affect immunocompetent patients. Methodology: This was a cross sectional study conducted in the Department of Medicine of a tertiary teaching institution in North India. All the patients diagnosed with CM on the basis of detection of cryptococcal antigen or the presence of capsulated budding yeast cells on India ink preparation, from April 2009 to March2015 were included in the study...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29318545/autophagy-and-proteases-basic-study-of-the%C3%A2-autophagic-flux-by-western-blot
#6
Álvaro F Fernández
Autophagy is a catabolic process triggered in the cell by a wide range of stress stimuli, both external (including nutrient deprivation) and internal (like the presence of protein aggregates or damaged organelles). First described in yeast, this pathway has recently gained major importance due to its role in several pathologies, from inflammatory processes to cancer or aging. However, its analysis can be easily misinterpreted if it is not done properly, leading to conflicting results. Here, the classical autophagy flux study by Western blot is described, as a first and basic analysis of the status of autophagy in a given system...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29290964/tetratricopeptide-repeat-domain-3-overexpression-tends-to-form-aggregates-and-inhibit-ubiquitination-and-degradation-of-dna-polymerase-%C3%AE
#7
Yueqing Gong, Xiaolan Wang, Xuan Shang, Sheng Ping Xiao, Wanjie Li, Yu Shang, Fei Dou
Tetratricopeptide repeat (TPR) domain 3 (TTC3) is a protein that contains canonical RING finger and TPR motifs. It is encoded by the TTC3 gene located in the Down syndrome critical region (DSCR). In this study, we used a yeast two-hybrid assay to identify several proteins that physically interact with TTC3, including heat shock proteins and DNA polymerase γ (POLG). When TTC3 was overexpressed in mammalian cells, the ubiquitination of POLG was inhibited and its degradation slowed. High TTC3 protein expression led to the development of intracellular TTC3 aggregates, which also contained POLG...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285768/optimization-of-culture-conditions-for-penicilazaphilone-c-production-by-a-marine-derived-fungus-penicillium-sclerotiorum-m-22
#8
Huan-Ge Zhao, Ming Wang, Ying-Ying Lin, Song-Lin Zhou
The aim of this study was to optimize the culture conditions of a marine-derived fungus Penicillium sclerotiorum M-22 for the production of penicilazaphilone C (PAC), a novel azaphilonidal derivative exhibiting broad cytotoxic and antibacterial effects. By single factor experiments, the effects to the production of PAC of aged seawater concentration, initial pH values, fermentation time, carbon sources, nitrogen sources and inorganic salt sources were investigated individually. Response surface methodology (RSM) analysis was adopted to investigate the interactions between variables and determine the optimal values for maximum PAC production...
December 29, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29283340/heat-stress-promotes-longevity-in-budding-yeast-by-relaxing-the-confinement-of-age-promoting-factors-in-the-mother-cell
#9
Sandro Baldi, Alessio Bolognesi, Anne Cornelis Meinema, Yves Barral
Although individuals of many species inexorably age, a number of observations established that the rate of ageing is modulated in response to a variety of mild stresses. Here, we investigated how heat stress promotes longevity in yeast. We show that upon growth at higher temperature, yeast cells relax the retention of DNA circles, which act as ageing factors in the mother cell. The enhanced frequency at which circles redistribute to daughter cells was not due to changes of anaphase duration or nuclear shape but solely to the downregulation of the diffusion barrier in the nuclear envelope...
December 28, 2017: ELife
https://www.readbyqxmd.com/read/29283326/sirtuins-in-brain-aging-and-neurological-disorders
#10
Muhammad Imran Qadir, Sidra Anwar
The many ways of aging have been and continue to be investigated. For this reason, over many years, several studies have resolved some of the genetic details underlying aging processes. It resulted in the identification of a yeast gene known as Sir2, which is a longevity modulator. Sir2 and SIRT1 are the mammalian homologs of yeast genes. Sirtuins (including SIRT1) play an important role in aging of the brain and the metabolic regulation pathway in mammals. Aging in the brain is caused by the loss of neurophysiologic functions due to neurodegeneration...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29277922/glutathione-levels-influence-chronological-life-span-of-saccharomyces-cerevisiae-in-a-glucose-dependent-manner
#11
Mayra Fabiola Tello-Padilla, Alejandra Yudid Perez-Gonzalez, Melina Canizal-García, Juan Carlos González-Hernández, Christian Cortes-Rojo, Ivanna Karina Olivares-Marin, Luis Alberto Madrigal-Perez
Diet plays a key role in determining the longevity of the organisms since it has been demonstrated that glucose restriction increases lifespan whereas a high-glucose diet decreases it. However, the molecular basis of how diet leads to the aging process is currently unknown. We propose that the quantity of glucose that fuels respiration influences ROS generation and glutathione levels, and both chemical species impact in the aging process. Herein, we provide evidence that mutation of the gene GSH1 in S. cerevisiae diminishes glutathione levels...
December 26, 2017: Yeast
https://www.readbyqxmd.com/read/29277170/supplementing-a-yeast-derived-product-to-enhance-productive-and-health-responses-of-beef-steers
#12
L G T Silva, R F Cooke, K M Schubach, A P Brandão, R S Marques, T F Schumaher, P Moriel, D W Bohnert
This experiment evaluated the impacts of supplementing a yeast-derived product (Celmanax; Church & Dwight Co., Inc., Princeton, NJ, USA) on productive and health responses of beef steers, and was divided into a preconditioning (days 4 to 30) and feedlot receiving phase (days 31 to 69). In all, 84 Angus × Hereford steers were weaned on day 0 (BW=245±2 kg; age=186±2 days), and maintained in a single group from days 0 to 3. On day 4, steers were allocated according to weaning BW and age to a 21-pen drylot (4 steers/pen)...
December 26, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29273704/mitogen-activated-protein-kinases-fus3-and-kss1-regulate-chronological-lifespan-in-yeast
#13
Maneesha Aluru, Tori McKinney, Anne-Kathryn L Venero, Shilpa Choudhury, Matthew Torres
Using a systems-based approach, we have identified several genes not previously evaluated for a role(s) in chronological aging. Here, we have thoroughly investigated the chronological lifespan (CLS) of three of these genes (FUS3, KSS1 and HOG1) and their protein products, each of which have well-defined cell signaling roles in young cells. The importance of FUS3 and KSS1 in CLS are largely unknown and analyzed here for the first time. Using both qualitative and quantitative CLS assays, we show that deletion of any of the three MAPK's increases yeast lifespan...
December 21, 2017: Aging
https://www.readbyqxmd.com/read/29260307/emerging-roles-for-sphingolipids-in-cellular-aging
#14
REVIEW
Pushpendra Singh, Rong Li
Aging is a gradual loss of physiological functions as organisms' progress in age. Although aging in multicellular organisms is complex, some fundamental mechanisms and pathways may be shared from the single cellular yeast to human. Budding yeast Saccharomyces cerevisiae has been established model system for aging studies. A yeast cell divides asymmetrically to produce two cells that differ in size and age. The one that is smaller coming from bud is a newborn cell that with a full replicative potential head irrespective of the replicative age of its mother-the larger cell from which the bud grows out before division...
December 19, 2017: Current Genetics
https://www.readbyqxmd.com/read/29239314/taking-out-the-garbage-cathepsin-d-and-calcineurin-in-neurodegeneration
#15
REVIEW
Andreas Aufschnaiter, Verena Kohler, Sabrina Büttner
Cellular homeostasis requires a tightly controlled balance between protein synthesis, folding and degradation. Especially long-lived, post-mitotic cells such as neurons depend on an efficient proteostasis system to maintain cellular health over decades. Thus, a functional decline of processes contributing to protein degradation such as autophagy and general lysosomal proteolytic capacity is connected to several age-associated neurodegenerative disorders, including Parkinson's, Alzheimer's and Huntington's diseases...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29234670/mitochondrial-energy-metabolism-is-required-for-lifespan-extension-by-the-spastic-paraplegia-associated-protein-spartin
#16
Julia Ring, Patrick Rockenfeller, Claudia Abraham, Jelena Tadic, Michael Poglitsch, Katherina Schimmel, Julia Westermayer, Simon Schauer, Bettina Achleitner, Christa Schimpel, Barbara Moitzi, Gerald N Rechberger, Stephan J Sigrist, Didac Carmona-Gutierrez, Guido Kroemer, Sabrina Büttner, Tobias Eisenberg, Frank Madeo
Hereditary spastic paraplegias, a group of neurodegenerative disorders, can be caused by loss-of-function mutations in the protein spartin. However, the physiological role of spartin remains largely elusive. Here we show that heterologous expression of human or Drosophila spartin extends chronological lifespan of yeast, reducing age-associated ROS production, apoptosis, and necrosis. We demonstrate that spartin localizes to the proximity of mitochondria and physically interacts with proteins related to mitochondrial and respiratory metabolism...
November 30, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29224051/quercetin-protects-yeast-saccharomyces-cerevisiae-pep4-mutant-from-oxidative-and-apoptotic-stress-and-extends-chronological-lifespan
#17
Phaniendra Alugoju, Sudharshan Setra Janardhanshetty, Subasri Subaramanian, Latha Periyasamy, Madhu Dyavaiah
The yeast Saccharomyces cerevisiae PEP4 gene encodes vacuolar endopeptidase proteinase A (Pep4p), which is a homolog of the human CTSD gene that encodes cathepsin D. Mutation of CTSD gene in human resulted in a number of neurodegenerative diseases. In this study, we have shown that yeast pep4 mutant cells are highly sensitive to oxidative and apoptotic stress induced by hydrogen peroxide and acetic acid, respectively. pep4∆ cells also showed accumulation of reactive oxygen species (ROS), apoptotic markers, and reduced chronological lifespan...
December 9, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29212000/is-aggregate-dependent-yeast-aging-fortuitous-a-model-of-damage-segregation-and-aggregate-dynamics
#18
Martín Andrade-Restrepo
During cytokinesis in Saccharomyces cerevisiae, damaged proteins are distributed unequally between the daughter and mother cells. The retention of these proteins is correlated with yeast aging. Even though evidence suggests that aggregates are retained due to an underlying molecular mechanism, the debate on whether an active mechanism is necessary for this asymmetry remains unsolved. In particular, passive diffusion and a bud-specific dilution remain as possible explanations. Here, a computational and mathematical model is provided to test whether passive mechanisms alone are sufficient to account for the aggregate distribution patterns and the aggregate kinetics observed in living cells...
December 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29211897/effect-of-yeast-cell-wall-on-the-growth-performance-and-gut-health-of-broilers-challenged-with-aflatoxin-b1-and-necrotic-enteritis
#19
N Liu, J Q Wang, S C Jia, Y K Chen, J P Wang
This study aimed to investigate the effect of yeast cell walls (YCW) on the growth performance, visceral lesions, intestinal integrity, enterotoxicity, and bacteria of broilers challenged with aflatoxin B1 (AF) and necrotic enteritis (NE) from 1 to 21 d of age. A total of 576 one-day-old broilers were assigned to a 2 × 2 × 2 design for diets containing AFB1 (0 or 40 μg/kg), NE (challenged or unchallenged), or YCW (0 or 500 mg/kg). The main effect analysis showed that AF depressed (P < 0.01) average daily feed intake (ADFI), average daily body weight gain (ADG), the mRNA profiles of polymeric Ig receptor (pIgR), claudin-1, and occludin, but increased (P < 0...
December 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/29207709/isolation-of-the-rare-opportunistic-yeast-saprochaete-capitata-from-clinical-samples-experience-from-a-tertiary-care-hospital-in-southern-india-and-a-brief-review-of-the-literature
#20
Umabala Pamidimukkala, Anuradha Kancharla, Sukanya Sudhaharan, Sadashivudu Gundeti, Surendra Mandarapu, Vamsi Krishna Nagalla, Sree Bhushan Raju, Sandhya Devi Karanam
Introduction: Saprochaete capitata (Teleomorph: Magnusiomyces capitatus) is a ubiquitous yeast found in environmental sources such as soil, water, air, plants and dairy products. It is also a part of the normal microbial flora in humans. The yeast is being increasingly reported as an opportunistic pathogen, especially in patients in the haemato-oncology setting, the infection being often mistakenly diagnosed as invasive candidiasis. Aim: To review the epidemiological, clinical and microbiological features of six patients admitted in our hospital over a period of 10 years (from January 2007 to December 2016), from whom Saprochaete capitata was isolated...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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