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https://www.readbyqxmd.com/read/29144022/collagen-a-review-on-its-sources-and-potential-cosmetic-applications
#1
REVIEW
María Isabela Avila Rodríguez, Laura G Rodríguez Barroso, Mirna Lorena Sánchez
Collagen is a fibrillar protein that conforms the conjunctive and connective tissues in the human body, essentially skin, joints, and bones. This molecule is one of the most abundant in many of the living organisms due to its connective role in biological structures. Due to its abundance, strength and its directly proportional relation with skin aging, collagen has gained great interest in the cosmetic industry. It has been established that the collagen fibers are damaged with the pass of time, losing thickness and strength which has been strongly related with skin aging phenomena [Colágeno para todo...
November 16, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29142076/spatial-cues-and-not-spindle-pole-maturation-drive-the-asymmetry-of-astral-microtubules-between-new-and-pre-existing-spindle-poles
#2
Jette Lengefeld, Eric Yen, Xiuzhen Chen, Allen Leary, Jackie Vogel, Yves Barral
In many asymmetrically dividing cells, the microtubule-organizing centers (MTOCs; mammalian centrosome and yeast spindle pole body - SPB) nucleate more astral microtubules on one of the two spindle poles than the other. This differential activity generally correlates with the age of MTOCs and contributes to orienting the mitotic spindle within the cell. The asymmetry might results from the two MTOCs being in distinctive maturation states. We investigated this model in budding yeast. Using fluorophores with different maturation kinetics to label the outer plaque components of the SPB, we found that the Cnm67 protein is mobile, whereas Spc72 is not...
November 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29137911/effect-of-supplementing-a-diet-with-monensin-sodium-and-saccharomyces-cerevisiae-on-reproductive-performance-of-ghezel-ewes
#3
Leila Ahmadzadeh, Ali Hosseinkhani, Hossein Daghighkia
Effect of supplementing a diet, in an attempt to enhance reproduction, with monensin sodium and Saccharomyces cerevisiae yeast on reproductive performance was investigated during the breeding season using 44 Ghezel ewes (body weight 56.97±7.47kg, age 2-5 years and body condition score (BCS) 2.5) which were allocated randomly in equal numbers to the four dietary treatments as follows: 1) Basal diet plus supplemental feed (450g/ewe/d) plus monensin sodium (30mg/ewe/d) (MS); 2) Basal diet plus supplemental feed (450 g/ewe/d) plusSaccharomyces cerevisiae yeast (4×10(9)CFU/ewe/d) (SC); 3) Basal diet plus supplemental feed (450g/ewe/d) (FG); 4) Basal diet (only grazing on pasture, Control; G)...
November 11, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29132795/-interdigital-tinea-pedis-resulting-from-fusarium-spp-in-dakar-senegal
#4
K Diongue, M A Diallo, M Ndiaye, M C Seck, A S Badiane, D Ndiaye
INTRODUCTION: Fungal interdigital tinea pedis (ITP) is a common pathology mainly due to dermatophytes and yeasts. Fusarium sp. is rarely incriminated in the genesis of intertrigo. In Dakar, a recent study conducted in 2016 on fungal ITP showed that Fusarium were more involved in the etiology of ITP than dermatophytes, coming just after yeasts dominated by Candida. Following this, we wanted to draw attention to the increasing incidence of ITP resulting from Fusarium spp., in Dakar, Senegal, and to analyze the epidemiological and mycological particularities of these ITP due to Fusarium spp...
November 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29130578/sirt3-deregulation-is-linked-to-mitochondrial-dysfunction-in-alzheimer-s-disease
#5
Junghee Lee, Yunha Kim, Tian Liu, Yu Jin Hwang, Seung Jae Hyeon, Hyeonjoo Im, Kyungeun Lee, Victor E Alvarez, Ann C McKee, Soo-Jong Um, Manwook Hur, Inhee Mook-Jung, Neil W Kowall, Hoon Ryu
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Despite decades of study, effective treatments for AD are lacking. Mitochondrial dysfunction has been closely linked to the pathogenesis of AD, but the relationship between mitochondrial pathology and neuronal damage is poorly understood. Sirtuins (SIRT, silent mating type information regulation 2 homolog in yeast) are NAD-dependent histone deacetylases involved in aging and longevity. The objective of this study was to investigate the relationship between SIRT3 and mitochondrial function and neuronal activity in AD...
November 11, 2017: Aging Cell
https://www.readbyqxmd.com/read/29126627/-clinical-and-mycological-characteristics-of-onychomycosis-due-to-candida-at-institut-pasteur-of-c%C3%A3-te-d-ivoire
#6
K E Angora, A Ira-Bonouman, A H Vanga-Bosson, A Konaté, F K Kassi, K Tuo, K Sylla-Thanon, P C Kiki-Barro, S Miezan, A V Bedia-Tanoh, V Djohan, W Yavo, E H Menan, A T Offianan
OBJECTIVE: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire. PATIENTS AND METHODS: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded. RESULTS: In this study, 1898 patient files were selected...
November 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29121651/a-modeling-study-of-budding-yeast-colony-formation-and-its-relationship-to-budding-pattern-and-aging
#7
Yanli Wang, Wing-Cheong Lo, Ching-Shan Chou
Budding yeast, which undergoes polarized growth during budding and mating, has been a useful model system to study cell polarization. Bud sites are selected differently in haploid and diploid yeast cells: haploid cells bud in an axial manner, while diploid cells bud in a bipolar manner. While previous studies have been focused on the molecular details of the bud site selection and polarity establishment, not much is known about how different budding patterns give rise to different functions at the population level...
November 9, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29121176/breaking-the-ceiling-of-human-maximal-lifespan
#8
Moshe Shay Ben-Haim, Yariv Kanfi, Sarah J Mitchel, Noam Maoz, Kelli Vaughan, Ninette Amariglio, Batia Lerrer, Rafael de Cabo, Gideon Rechavi, Haim Y Cohen
While average human life expectancy has increased dramatically in the last century, the maximum lifespan has only modestly increased. These observations prompted the notion that human lifespan might have reached its maximal natural limit of ~115 years. To evaluate this hypothesis, we conducted a systematic analysis of all-cause human mortality throughout the 20 th century. Our analyses revealed that, once cause of death is accounted for, there is a proportional increase in both median age of death and maximum lifespan...
November 7, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29097398/cell-biology-of-the-mitochondrion
#9
Alexander M van der Bliek, Margaret M Sedensky, Phil G Morgan
Mitochondria are best known for harboring pathways involved in ATP synthesis through the tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding these roles were made with Caenorhabditiselegans mutants affecting key components of the metabolic pathways. These mutants have not only helped elucidate some of the intricacies of metabolism pathways, but they have also served as jumping off points for pharmacology, toxicology, and aging studies. The field of mitochondria research has also undergone a renaissance, with the increased appreciation of the role of mitochondria in cell processes other than energy production...
November 2017: Genetics
https://www.readbyqxmd.com/read/29091711/the-regulation-of-autophagy-differentially-affects-trypanosoma-cruzi-metacyclogenesis
#10
María Cristina Vanrell, Antonella Denisse Losinno, Juan Agustín Cueto, Darío Balcazar, Laura Virginia Fraccaroli, Carolina Carrillo, Patricia Silvia Romano
Autophagy is a cellular process required for the removal of aged organelles and cytosolic components through lysosomal degradation. All types of eukaryotic cells from yeasts to mammalian cells have the machinery to activate autophagy as a result of many physiological and pathological situations. The most frequent stimulus of autophagy is starvation and the result, in this case, is the fast generation of utilizable food (e.g. amino acids and basic nutrients) to maintain the vital biological processes. In some organisms, starvation also triggers other associated processes such as differentiation...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29081086/diversity-and-characteristics-of-meat-microbiological-community-on-dry-aged-beef
#11
Sangdon Ryu, Mi Ri Park, Brighton E Maburutse, Su Jin Lee, Woong Ji Lee, Soohyun Cho, Inho Hwang, Sangnam Oh, Younghoon Kim
Beef was dry aged for 40 to 60 days under controlled environmental conditions in a refrigerated room with a relative humidity of 75% to 80 % and air-flow. To date, there is little information on the microbial diversity and characteristics of dry aged beef. Here, we explored the effect of change in meat microorganisms on dry aged beef. Initially, total bacteria and LAB were significantly increased for 50 days during all dry aging periods. There was absence of representative foodborne pathogens as well as coliforms...
October 30, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29073021/multigenerational-silencing-dynamics-control-cell-aging
#12
Yang Li, Meng Jin, Richard O'Laughlin, Philip Bittihn, Lev S Tsimring, Lorraine Pillus, Jeff Hasty, Nan Hao
Cellular aging plays an important role in many diseases, such as cancers, metabolic syndromes, and neurodegenerative disorders. There has been steady progress in identifying aging-related factors such as reactive oxygen species and genomic instability, yet an emerging challenge is to reconcile the contributions of these factors with the fact that genetically identical cells can age at significantly different rates. Such complexity requires single-cell analyses designed to unravel the interplay of aging dynamics and cell-to-cell variability...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29062327/risk-factors-associated-with-acquiring-superficial-fungal-infections-in-school-children-in-south-western-nigeria-a-comparative-study
#13
Olaide Oke Olutoyin, Olaniyi Onayemi, Akinlolu Omisore Gabriel
INTRODUCTION: Superficial fungal infections (SFI) are caused mainly by dermatophytes and yeasts. SFI is of major public health concern and is a common cause of skin disease among school children. OBJECTIVES: The aim of this study was to identify the risk factors associated with acquiring superficial fungal infections in school children in Ile-Ife, South West Nigeria as this will assist in instituting appropriate interventions. METHODS: A total of 560 children; 280 with superficial fungal infections as subjects and 280 age and sex matched school children as controls were recruited through multistage sampling method from 10 primary schools (private and public owned) in Ile-Ife, Nigeria...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29053876/blood-hematological-and-biochemical-constituents-antioxidant-enzymes-immunity-and-lymphoid-organs-of-broiler-chicks-supplemented-with-propolis-bee-pollen-and-mannan-oligosaccharides-continuously-or-intermittently
#14
Y A Attia, H Al-Khalaifah, M S Ibrahim, A E Abd Al-Hamid, M A Al-Harthi, A El-Naggar
This study investigate the effect of bee pollen (BP) and/or propolis (Pro) as an alternative to Mannan oligosaccharides (Bio-MOS, a hydrolyzed yeast with natural and artificial flavors Alltech Inc) when given continuously or intermittently on antioxidant enzymes, immunity, weight and morphology of lymphoid organs of broilers. Thus, 324 unsexed one-day-old Arbor Acres broilers were randomly distributed into nine treatment groups, each replicated 6 times of 6 birds per replicate. The chicks were kept in wire cages and fed the same basal diet and were submitted to the following treatments: control without supplementation (control) or supplemented with BP at 300 mg, Pro at 300 mg, BP+Pro at 300 mg each and Bio-MOS at 0...
October 10, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050207/caloric-restriction-extends-yeast-chronological-lifespan-via-a-mechanism-linking-cellular-aging-to-cell-cycle-regulation-maintenance-of-a-quiescent-state-entry-into-a-non-quiescent-state-and-survival-in-the-non-quiescent-state
#15
Anna Leonov, Rachel Feldman, Amanda Piano, Anthony Arlia-Ciommo, Vicky Lutchman, Masoumeh Ahmadi, Sarah Elsaser, Hana Fakim, Mahdi Heshmati-Moghaddam, Asimah Hussain, Sandra Orfali, Harshvardhan Rajen, Negar Roofigari-Esfahani, Leana Rosanelli, Vladimir I Titorenko
A yeast culture grown in a nutrient-rich medium initially containing 2% glucose is not limited in calorie supply. When yeast cells cultured in this medium consume glucose, they undergo cell cycle arrest at a checkpoint in late G1 and differentiate into quiescent and non-quiescent cell populations. Studies of such differentiation have provided insights into mechanisms of yeast chronological aging under conditions of excessive calorie intake. Caloric restriction is an aging-delaying dietary intervention. Here, we assessed how caloric restriction influences the differentiation of chronologically aging yeast cultures into quiescent and non-quiescent cells, and how it affects their properties...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048268/density-separation-of-quiescent-yeast-using-iodixanol
#16
Ishtiaque Quasem, Christopher J Luby, Charles R Mace, Stephen M Fuchs
As yeast are starved of nutrients, they enter G0, a quiescent state. Quiescent yeast (Q) cells retain viability for extended periods of time and resume growth following supplementation of missing nutrients. As such, Q cells have become a valuable model for studying longevity and self-renewal of chronologically aged cells. Traditional isolation of Q cells involves a relatively long centrifugation time through a continuous density gradient. Here, we describe a rapid and cost-effective Q-cell isolation technique that uses a single-density, one-step gradient prepared from media containing iodixanol...
October 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29044689/behead-and-live-long-or-the-tale-of-cathepsin-l
#17
Maria Karolin Streubel, Johannes Bischof, Richard Weiss, Jutta Duschl, Wolfgang Liedl, Herbert Wimmer, Michael Breitenbach, Manuela Weber, Florian Geltinger, Klaus Richter, Mark Rinnerthaler
In the last decades S. cerevisiae has proven to be one of the most valuable model organisms of aging research. Pathways as autophagy or the effect of substances like resveratrol and spermidine that prolong the replicative as well as chronological lifespan of cells have been described for the first time in S. cerevisiae. In this study we describe the establishment of an aging reporter that allows a reliable and relative quick screening of substances and genes that have an impact on the replicative lifespan. A cDNA library of the flatworm Dugesia tigrina that can be immortalized by beheading was screened using this aging reporter...
October 17, 2017: Yeast
https://www.readbyqxmd.com/read/29043098/spermidine-is-protective-against-kidney-ischemia-and-reperfusion-injury-through-inhibiting-dna-nitration-and-parp1-activation
#18
Jinu Kim
Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative and nitrative stresses; however, an effective approach to limit IRI remains elusive. Spermidine, a naturally occurring polyamine, protects yeast cells against aging through the inhibition of oxidative stress and necrosis. In the present study, spermidine supplementation markedly attenuated histological damage and kidney dysfunction during IRI. In addition, exogenous spermidine potently inhibited poly(ADP-ribose) polymerase 1 (PARP1) activation and DNA nitrative/oxidative stress following IRI...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29038504/the-contribution-of-saccharomyces-cerevisiae-replicative-age-to-the-variations-in-the-levels-of-trx2p-pdr5p-can1p-and-idh-isoforms
#19
Aglaia V Azbarova, Kseniia V Galkina, Maxim I Sorokin, Fedor F Severin, Dmitry A Knorre
Asymmetrical division can be a reason for microbial populations heterogeneity. In particular, budding yeast daughter cells are more vulnerable to stresses than the mothers. It was suggested that yeast mother cells could also differ from each other depending on their replicative age. To test this, we measured the levels of Idh1-GFP, Idh2-GFP, Trx2-GFP, Pdr5-GFP and Can1-GFP proteins in cells of the few first, most represented, age cohorts. Pdr5p and Can1p were selected because of the pronounced mother-bud asymmetry for these proteins distributions, Trx2p as indicator of oxidative stress...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29036198/the-homeodomain-interacting-protein-kinase-hpk-1-preserves-protein-homeostasis-and-longevity-through-master-regulatory-control-of-the-hsf-1-chaperone-network-and-torc1-restricted-autophagy-in-caenorhabditis-elegans
#20
Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding with many clinical manifestations, including protein aggregation diseases of the nervous system. A decline in proteostasis can be delayed through the activation of cytoprotective transcriptional responses, which are sensitive to environmental stress and internal metabolic and physiological cues...
October 2017: PLoS Genetics
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