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https://www.readbyqxmd.com/read/29779283/-prevalence-survey-of-dental-trauma-to-immature-permanent-teeth-in-xi-an-schoolchildren
#1
Xiao-Min Wang, Xue-Long Su, Hong Wang, Fei Liu, Ya-Ping Zhao, Qing-Yu Guo
OBJECTIVE: The prevalence rate, distribution, and reasons of immature permanent-tooth trauma in Xi'an were investigated and described, and a scientific basis was provided for the decision-making of health-administration departments. METHODS: Through cluster and simple random sampling survey, 4 013 pupils in schools from nine districts and four counties in Xi'an were sampled. All pupils and their parents were requested to complete a questionnaire. Oral examinations were conducted for children who had immature permanent teeth trauma...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29779223/gene-editing-vectors-for-studying-nicotinic-acetylcholine-receptors-in-cholinergic-transmission
#2
Can Peng, Yijin Yan, Veronica J Kim, Staci E Engle, Jennifer N Berry, J Michael McIntosh, Rachael L Neve, Ryan M Drenan
Nicotinic acetylcholine receptors (nAChRs), prototype members of the cys-loop ligand gated ion channel family, are key mediators of cholinergic transmission in the central nervous system. Despite their importance, technical gaps exist in our ability to dissect the function of individual subunits in the brain. To overcome these barriers, we designed CRISPR/Cas9 small guide RNA sequences (sgRNAs) for production of loss-of-function alleles in mouse nAChR genes. These sgRNAs were validated in vitro via deep sequencing...
May 19, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29779187/dualism-and-its-place-in-a-philosophical-structure-for-psychiatry
#3
Hane Htut Maung
It is often claimed in parts of the psychiatric literature that neuroscientific research into the biological basis of mental disorder undermines dualism in the philosophy of mind. This paper shows that such a claim does not apply to all forms of dualism. Focusing on Kenneth Kendler's discussion of the mind-body problem in biological psychiatry, I argue that such criticism of dualism often conflates the psychological and phenomenal concepts of the mental. Moreover, it fails to acknowledge that there are different varieties of dualism, and so overlooks the important metaphysical insights of contemporary dualist philosophers...
May 19, 2018: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29778992/school-area-road-safety-assessment-and-improvements-sarsai-programme-reduces-road-traffic-injuries-among-children-in-tanzania
#4
Ayikai Poswayo, Simon Kalolo, Katheryn Rabonovitz, Jeffrey Witte, Alejandro Guerrero
PURPOSE: To determine the impact of a paediatric road traffic injury (RTI) prevention programme in urban Sub-Saharan Africa. SETTING: Dares Salaam, Republic of Tanzania. METHODS: Household surveys were conducted in catchment areas around 18 primary schools in Dar es Salaam, Republic of Tanzania; the catchment areas were divided into control and intervention groups. Collected data included basic demographic information on all school-aged household members and whether or not they had been involved in an RTI in the previous 12 months, and, if so, what the characteristics of that RTI were...
May 19, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#5
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29778663/glp-1-receptor-agonists-and-reduction-of-cardiometabolic-risk-potential-underlying-mechanisms
#6
REVIEW
Manfredi Rizzo, Dragana Nikolic, Angelo Maria Patti, Carlo Mannina, Giuseppe Montalto, Brooke S McAdams, Ali A Rizvi, Francesco Cosentino
Type 2 diabetes mellitus (T2DM) is a metabolic condition with an elevated impact on cardiovascular (CV) risk. The innovative therapeutic approaches for T2DM - incretin-based therapies (IBTs), including glucagon-like peptide 1 (GLP-1) receptor agonists, have become popular and more widely used in recent years. The available scientific data from clinical studies and clinical practice highlights their beyond glucose-lowering effects, which is achieved without any increase in hypoglycaemia. The former effects include reduction in body weight, lipids, blood pressure, inflammatory markers, oxidative stress, endothelial dysfunction, and subclinical atherosclerosis, thus reducing and potentially preventing CV events...
May 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29778520/effectiveness-of-hpv-vaccination-against-high-grade-cervical-lesions-in-japan
#7
Ryo Konno, Hiroshi Konishi, Catherine Sauvaget, Yasuo Ohashi, Tadao Kakizoe
The effectiveness of HPV vaccine against HSIL+ (pathologically diagnosed CIN2+) in the first cohort in Japan was investigated in 22,743 women aged 20 to 29 years (parts of national cervical cancer screening program of FY [fiscal year] 2015, the Japan Cancer Society). Vaccinated women had a statistically significant 69% lower risk of HSIL+ as compared to the unvaccinated women; the crude relative risk estimate was 0.31 (95% CI: 0.11-0.83; p-value = 0.013) by normal approximation and 0.31 (95% CI: 0.08-0...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29778485/meta-analysis-of-2-hydroxy-4-methylthio-butanoic-acid-supplementation-on-ruminal-fermentation-milk-production-and-nutrient-digestibility
#8
X Feng, R R White, H A Tucker, M D Hanigan
Methionine is considered one of the most important essential AA for milk protein synthesis in dairy cows. Supplementation of unprotected, free Met is nearly 100% degraded by ruminal microorganisms, which complicates supplementation. 2-Hydroxy-4-methylthio-butanoic acid (HMTBa) can be converted to Met in the body and is used as a Met source in dairy production. However, results of published studies assessing the effects of supplementing Met sources, including HMTBa, on performance variables are inconsistent...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29778336/implementation-of-the-aortic-no-touch-technique-to-reduce-stroke-after-off-pump-coronary-surgery
#9
Alexander Albert, Jürgen Ennker, Yasser Hegazy, Sebastian Ullrich, Georgi Petrov, Payam Akhyari, Stefan Bauer, Eda Ürer, Ina Carolin Ennker, Artur Lichtenberg, Horst Priss, Alexander Assmann
OBJECTIVES: Despite substantial scientific effort, the relationship between stroke after coronary artery bypass grafting and the use of the aortic no-touch off-pump technique (anOPCAB) remains incompletely understood. The present study aimed to define the effect of anOPCAB on the occurrence and time point of stroke. METHODS: A total cohort of 15,042 consecutive patients underwent surgical myocardial revascularization at a single institution. After establishing anOPCAB as routine procedure, 4695 patients received surgery by 18 different surgeons using the anaortic approach...
April 11, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29778174/development-of-methods-for-establishing-nutrient-criteria-in-lakes-and-reservoirs-a-review
#10
REVIEW
Shouliang Huo, Chunzi Ma, Beidou Xi, Yali Zhang, Fengchang Wu, Hongliang Liu
Nutrient criteria provide a scientific foundation for the comprehensive evaluation, prevention, control and management of water eutrophication. In this review, the literature was examined to systematically evaluate the benefits, drawbacks, and applications of statistical analysis, paleolimnological reconstruction, stressor-response model, and model inference approaches for nutrient criteria determination. The developments and challenges in the determination of nutrient criteria in lakes and reservoirs are presented...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29778159/effects-of-1-octyl-3-methylimidazolium-nitrate-on-the-microbes-in-brown-soil
#11
Cheng Zhang, Jun Wang, Lusheng Zhu, Zhongkun Du, Jinhua Wang, Xi Sun, Tongtong Zhou
The toxicity of ionic liquids (ILs) on soil organisms has aroused wide attention due to their high-solubility. The present investigation focused on the toxicity of 1-octyl-3-methylimidazolium nitrate ([C8 mim]NO3 ) on the microbial populations (bacteria, fungi, and actinomycetes), soil enzyme (urease, dehydrogenase, acid phosphatase, and β-glucosidase) activities, microbial community diversity using terminal restriction fragment length polymorphism (T-RFLP), and abundance of the ammonia monooxygenase (amoA) genes of ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) using quantitative real-time polymerase chain reaction (q-PCR) in brown soil at each trial with doses of 0, 1...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29778151/regionalization-based-on-spatial-and-seasonal-variation-in-ground-level-ozone-concentrations-across-china
#12
Linjun Cheng, Shuai Wang, Zhengyu Gong, Hong Li, Qi Yang, Yeyao Wang
Owing to the vast territory of China and strong regional characteristic of ozone pollution, it's desirable for policy makers to have a targeted and prioritized regulation and ozone pollution control strategy in China based on scientific evidences. It's important to assess its current pollution status as well as spatial and temporal variation patterns across China. Recent advances of national monitoring networks provide an opportunity to insight the actions of ozone pollution. Here, we present rotated empirical orthogonal function (REOF) analysis that was used on studying the spatiotemporal characteristics of daily ozone concentrations...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29777858/cd44-targeted-plga-nanomedicines-for-cancer-chemotherapy
#13
REVIEW
Ankit Saneja, Divya Arora, Robin Kumar, Ravindra Dhar Dubey, Amulya K Panda, Prem N Gupta
In recent years scientific community has drawn a great deal of attention towards understanding the enigma of cluster of differentiation-44 (CD44) in order to deliver therapeutic agents more selectively towards tumor tissues. Moreover, its over-expression in variety of solid tumors has attracted drug delivery researchers to target this receptor with nanomedicines. Conventional nanomedicines based on biodegradable polymers such as poly(lactide-co-glycolide) (PLGA) are often associated with insufficient cellular uptake by cancer cells, due to lack of active targeting moiety on their surface...
May 16, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29777706/n-3-polyunsaturated-fatty-acids-ameliorate-hepatic-steatosis-via-the-ppar-%C3%AE-cpt-1%C3%AE-pathway-in-a-mouse-model-of-parenteral-nutrition
#14
Feng Tian, Jiwei Wang, Haifeng Sun, Jianbo Yang, Peng Wang, Songlin Wan, Xuejin Gao, Li Zhang, Jieshou Li, Xinying Wang
Parenteral nutrition (PN) is one of the basic therapies for patients with intestinal failure; however, hepatic steatosis associated with PN limits the long-term use of PN. N-3 polyunsaturated fatty acids (PUFAs) have been used to improve clinical outcomes of patients receiving PN; however, the mechanisms by which n-3 PUFAs ameliorate hepatic steatosis remain unclear. In the present study, C57BL/6J mice were randomly assigned to three treatment groups, namely, enteral nutrition (EN), n-3 PUFAs, and n-6 PUFAs...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29777340/2017-update-of-the-turkish-league-against-rheumatism-tlar-evidence-based-recommendations-for-the-management-of-knee-osteoarthritis
#15
REVIEW
Tiraje Tuncer, Fatih Hasan Cay, Lale Altan, Gulcan Gurer, Cahit Kacar, Suheda Ozcakir, Sahap Atik, Figen Ayhan, Berrin Durmaz, Nurten Eskiyurt, Hakan Genc, Yesim GokceKutsal, Rezzan Gunaydin, Simin Hepguler, Sami Hizmetli, Taciser Kaya, Yesim Kurtais, Merih Saridogan, Dilsad Sindel, Serap Sutbeyaz, Omer Faruk Sendur, Hatice Ugurlu, Zeliha Unlu
In a Turkish League Against Rheumatism (TLAR) project, evidence-based recommendations for the management of knee osteoarthritis (OA) was developed for the first time in our country in 2012 (TLAR-2012). In accordance with developing medical knowledge and scientific evidence, recommendations were updated. The committee was composed of 22 physical medicine and rehabilitation specialists (4 have rheumatology subspeciality also) and an orthopaedic surgeon. Systematic literature search were applied on Pubmed, Embase, Cochrane and Turkish Medical Index for the dates between January the 1st 2012 and January the 29th of 2015...
May 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29777324/a-dependable-massive-storage-service-for-medical-imaging
#16
Marco Antonio Núñez-Gaona, Ricardo Marcelín-Jiménez, Josefina Gutiérrez-Martínez, Heriberto Aguirre-Meneses, José Luis Gonzalez-Compean
We present the construction of Babel, a distributed storage system that meets stringent requirements on dependability, availability, and scalability. Together with Babel, we developed an application that uses our system to store medical images. Accordingly, we show the feasibility of our proposal to provide an alternative solution for massive scientific storage and describe the software architecture style that manages the DICOM images life cycle, utilizing Babel like a virtual local storage component for a picture archiving and communication system (PACS-Babel Interface)...
May 18, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29776618/sleep-health-epidemiology-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis-of-the-prevalence-of-poor-sleep-quality-and-sleep-duration
#17
REVIEW
Guido Simonelli, Nathaniel S Marshall, Antigone Grillakis, Christopher B Miller, Camilla M Hoyos, Nick Glozier
Sleep research has been dominated by high income countries (HIC). Sleep may be different in low and middle income countries (LMIC) due to cultural, demographic, geographical and health factors. We systematically reviewed the epidemiological literature reporting sleep parameters in the adult population in LMIC and meta-analyzed the prevalence of subjective poor sleep quality and sleep duration. We identified 45 publications; over 50% of which came from China and Brazil. Of the 45 identified studies, 32 contained data on sleep quality and 17 on self-reported sleep duration...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29776573/duration-of-dual-antiplatelet-therapy-and-outcome-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-revascularization-a-meta-analysis-of-11-randomized-trials
#18
Monica Verdoia, Elvin Khedi, Claudia Ceccon, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Acute coronary syndromes (ACS) represent a context of higher thrombotic risk, where larger advantages have been achieved by the administration of dual antiplatelet therapy (DAPT). However, the indication of 1 year DAPT after coronary angioplasty for ACS has been supported by an outdated randomized trial (PCI-CURE). In addition, the initial fear of late thrombotic events emerged with first generation drug-eluting stents (DES), that suggested the need of a prolonged DAPT prescription, has been completely overcome by the recent technological evolution of DES, that have shown faster re-endothelization and lower rates of late thrombotic complications...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29776518/factors-associated-with-life-jacket-use-among-cabin-sailboat-and-day-sailor-boaters-in-the-united-states
#19
Natalie Spitzer, Maile T Phillips, Wendy Chow, Thomas W Mangione
INTRODUCTION: In 2015, drowning accounted for 68% of the 626 recreational boating related deaths in the United States. Although life jackets are estimated to prevent between 50% to 80% of boating deaths, approximately 83% of sailboat-related drowning victims were reported to not be wearing life jackets. Life jacket use among adult boaters has remained consistently low across most boat types and may vary by boater, boating, and environmental conditions. Although many risky environmental and boating factors may be associated with a higher risk of boating death, drowning occurs in all situations and it is useful to understand adult life jacket wearing behaviors in differing boating situations...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29776115/electroclinic-effect-in-the-chiral-lamellar-%C3%AE-phase-of-a-lyotropic-liquid-crystal
#20
Marc D Harjung, Frank Giesselmann
In thermotropic chiral Sm-A^{*} phases, an electric field along the smectic layers breaks the D_{∞} symmetry of the Sm-A^{*} phase and induces a tilt of the liquid crystal director. This so-called electroclinic effect (ECE) was first reported by Garoff and Meyer in 1977 and attracted substantial scientific and technological interest due to its linear and submicrosecond electro-optic response [S. Garoff and R. B. Meyer, Phys. Rev. A 19, 338 (1979)0556-279110.1103/PhysRevA.19.338]. We now report the observation of an ECE in the pretransitional regime from a lyotropic chiral lamellar L_{α}^{*} phase into a lyo-Sm-C^{*} phase, the lyotropic analog to the thermotropic Sm-C^{*} phase which was recently discovered by Bruckner et al...
March 2018: Physical Review. E
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