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EBV positive DLBcl

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https://www.readbyqxmd.com/read/28099151/clinical-impact-of-serum-survivin-positivity-and-tissue-expression-of-ebv-encoded-rna-in-diffuse-large-b-cell-lymphoma-patients-treated-with-rituximab-chop
#1
Jung Yong Hong, Kyung Ju Ryu, Chaehwa Park, Mineui Hong, Young Hyeh Ko, Won Seog Kim, Seok Jin Kim
Survivin is an inhibitor of apoptosis and is upregulated by Epstein-Barr virus (EBV) latent genes. Given the frequent association of EBV with lymphoid malignancies, survivin is expected to have prognostic value in diffuse large B-cell lymphoma (DLBCL). Thus, we measured the pretreatment serum level of survivin in DLBCL patients and analyzed its association with survival outcome and EBV status, as represented by EBV-encoded RNA (EBER) in DLBCL. Pretreatment serum survivin level was measured in patients registered in a prospective cohort study (n = 210), and serum survivin-positivity was defined as any detectable level of survivin...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28036258/epstein-barr-virus-ebna2-directs-doxorubicin-resistance-of-b-cell-lymphoma-through-ccl3-and-ccl4-mediated-activation-of-nf-%C3%AE%C2%BAb-and-btk
#2
Joo Hyun Kim, Won Seog Kim, Jung Yong Hong, Kung Ju Ryu, Seok Jin Kim, Chaehwa Park
Epstein-Barr virus (EBV)-encoded nuclear antigen, EBNA2, expressed in EBV-infected B lymphocytes is critical for lymphoblastoid cell growth. Microarray profiling and cytokine array screening revealed that EBNA2 is associated with upregulation of the chemokines CCL3 and CCL4 in lymphoma cells. Depletion or inactivation of CCL3 or CCL4 sensitized DLBCL cells to doxorubicin. Our results indicate that EBV influences cell survival via an autocrine mechanism whereby EBNA2 increases CCL3 and CCL4, which in turn activate the Btk and NF-κB pathways, contributing to doxorubicin resistance of B lymphoma cells...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27988064/cutaneous-ebv-related-lymphoproliferative-disorders
#3
Alejandro A Gru, Elaine S Jaffe
This article will focus on the cutaneous lymphoproliferative disorders associated with EBV, with an emphasis on the upcoming changes in the revised 4th Edition of the WHO classification of tumors of the hematopoietic system, many of which deal with cutaneous disorders derived from NK-cells or T-cells. Extranodal NK/T-cell lymphoma usually presents in the upper aerodigestive tract, but can involve the skin secondarily. EBV-associated T- and NK-cell lymphoproliferative disorders (LPD) in the pediatric age group include the systemic diseases, chronic active EBV infection (CAEBV) and systemic EBV+ T-cell lymphoma of childhood...
December 7, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27913781/synchronous-microscopic-epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma-of-the-adrenal-and-lymphoplasmacytic-lymphoma-de-novo-disease-or-transformation
#4
Mufaddal T Moonim, Alia Nasir, Jonathan Hubbard, Nicholas Ketley, Paul Fields
Lymphomas arising in the adrenal are rare, and to our knowledge, 2 cases of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphomas (DLBCL) in an adrenal pseudocyst have been reported. We report an incidental EBV-positive DLBCL arising in an adrenal pseudocyst in a 58-year-old man with a 7-year history of lymphoplasmacytic lymphoma (LPL). The DLBCL was present in the fibrinous exudate, while the LPL resided in the cyst wall. The patient underwent de-roofing of the same cyst 3 years previously; review of histology revealed foci of LPL in the cyst wall, but not of DLBCL...
December 2, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27785332/epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma-involving-the-colon-in-a-patient-with-ulcerative-pancolitis-and-polymyositis-on-long-term-methotrexate-therapy
#5
Michael D Chang, Merry-Jennifer Markham, Xiuli Liu
The link between immunosuppressive therapy and increased lymphoma risk is well established in patients with solid organ transplantation. Epstein-Barr virus-positive (EBV) diffuse large B-cell lymphoma (DLBCL) is known to be a complication in patients receiving methotrexate for rheumatoid arthritis, and the risk of lymphoma in inflammatory bowel disease (IBD) has raised concerns regarding the lymphoproliferative potential of immunomodulatory therapy. In this report, we describe a case of EBV-positive DLBCL arising within the colon of a patient affected by ulcerative pancolitis...
October 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/27782313/cytotoxic-epstein-barr-virus-positive-large-b-cell-lymphoma-a-regulatory-b-cell-derived-neoplasia
#6
Valentina Tabanelli, Vanessa Santiago-Pacheco, Mario Corbellino, Angelica Calleri, Claudio Agostinelli, Carlo Parravicini, Stefano A Pileri
AIMS: A new subtype of granzyme B (GrB)-producing regulatory B cells (Bregs ) has been described recently; these peculiar cytotoxic B cells are increased significantly in interleukin (IL)-21-rich settings, and in particular during HIV and Epstein-Barr virus (EBV) infection. Our aim is to report a unique case of an EBV-positive diffuse large B cell lymphoma (DLBCL) with cytotoxic features arisen in an HIV(+) patient, and to understand if this lesion may represent a proliferation of neoplastic cytotoxic Bregs ...
October 26, 2016: Histopathology
https://www.readbyqxmd.com/read/27735994/grey-zone-lymphoma-with-features-intermediate-between-diffuse-large-b-cell-lymphoma-and-classical-hodgkin-lymphoma-a-clinicopathological-study-of-14-epstein-barr-virus-positive-cases
#7
Ahmed A Elsayed, Akira Satou, Ahmed E Eladl, Seiichi Kato, Shigeo Nakamura, Naoko Asano
AIMS: To investigate the clinicopathological features of Epstein-Barr virus (EBV)-positive grey zone lymphoma (GZL) with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (CHL). METHODS AND RESULTS: We investigated the clinicopathological features of 14 cases of EBV-positive GZL in Japan. The control group included 173 cases of EBV-positive CHL and 64 cases of EBV-positive DLBCL of the elderly (polymorphous type)...
October 13, 2016: Histopathology
https://www.readbyqxmd.com/read/27569297/epstein-barr-virus-positive-mucocutaneous-ulcer-arising-in-a-post-hematopoietic-cell-transplant-patient-followed-by-polymorphic-posttransplant-lymphoproliferative-disorder-and-cytomegalovirus-colitis
#8
Akira Satou, Akio Kohno, Ryuichi Fukuyama, Ahmed Ali Elsayed, Shigeo Nakamura
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) is a newly described entity occurring in elderly or iatrogenically immunocompromised patients. We describe a case of EBVMCU arising in a post-hematopoietic cell transplant patient and followed by EBV-positive polymorphic posttransplant lymphoproliferative disorder (EBV(+) polymorphic PTLD). The patient, a 52-year-old woman, received chemotherapy and autologous peripheral blood stem cell transplantation for relapsed diffuse large B-cell lymphoma (DLBCL)...
January 2017: Human Pathology
https://www.readbyqxmd.com/read/27559423/cerebellar-ebv-associated-diffuse-large-b-cell-lymphoma-following-angioimmunoblastic-t-cell-lymphoma
#9
Yi Zhou, Marc K Rosenblum, Ahmet Dogan, Achim A Jungbluth, April Chiu
Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL...
December 2015: Journal of Hematopathology
https://www.readbyqxmd.com/read/27527850/pd-l1-expression-in-ebv-negative-diffuse-large-b-cell-lymphoma-clinicopathologic-features-and-prognostic-implications
#10
Wei Xing, Karen Dresser, Rui Zhang, Andrew M Evens, Hongbo Yu, Bruce A Woda, Benjamin J Chen
Programmed cell death ligand 1 (PD-L1) is a cell surface glycoprotein that regulates the cellular immune response and serves as a targetable immune checkpoint molecule. PD-L1 is expressed on tumor cells and the immune microenvironment of several human malignancies, including a subset of aggressive lymphomas. We sought to investigate further the clinical and pathologic features of EBV-negative diffuse large B-cell lymphoma (DLBCL) cases that express PD-L1. Immunohistochemical staining using an anti-PD-L1 monoclonal antibody was performed on DLBCL cases from 86 patients...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27488004/a-clinicopathological-study-of-primary-central-nervous-system-lymphomas-their-association-with-epstein-barr-virus
#11
Mehar Chand Sharma, Rakesh Kumar Gupta, Seema Kaushal, Vaishali Suri, Chitra Sarkar, Manmohan Singh, S S Kale, Ranjit K Sahoo, Lalit Kumar, Vinod Raina
BACKGROUND & OBJECTIVES: Primary central nervous system lymphomas (PCNSLs) are relatively uncommon, accounting for 2-3 per cent of primary brain tumours. Majority of these are diffuse large B cell lymphomas (DLBCL) occurring both in immunocompromised and immunocompetent patients. We undertook this study to classify PCNSL into germinal centre (GC) and non-germinal centre (NGC) type based on Hans classification and to find the role of Epstein-Barr virus (EBV) in pathogenesis both by conventional immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH)...
May 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27431583/epstein-barr-virus-negative-diffuse-large-b-cell-lymphoma-with-aberrant-expression-of-cd3-and-other-t-cell-associated-antigens-report-of-three-cases-with-a-review-of-the-literature
#12
Bin Wu, Bethany Vallangeon, Jonathan Galeotti, Siby Sebastian, Catherine Rehder, Endi Wang
Expression of CD3 on a mature B cell neoplasm, such as diffuse large B cell lymphoma (DLBCL), is extremely rare. When it is present, it will cause diagnostic confusion since the classification of lymphoid neoplasms is largely based on immunophenotyping to determine the cell lineage. We report three cases of DLBCL with CD3 and other T cell-associated antigens. A literature search identifies 30 additional cases of DLBCL expressing CD3, with the majority (78.6 %) displaying cytoplasmic expression, while two of our cases demonstrate membranous staining...
October 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27338098/regulation-of-ebv-lmp1-triggered-epha4-downregulation-in-ebv-associated-b-lymphoma-and-its-impact-on-patients-survival
#13
Ya-Chi Huang, Sue-Jane Lin, Kai-Min Lin, Ya-Ching Chou, Chung-Wu Lin, Shan-Chi Yu, Chi-Long Chen, Tang-Long Shen, Chi-Kuan Chen, Jean Lu, Mei-Ru Chen, Ching-Hwa Tsai
Epstein-Barr virus (EBV), an oncogenic human virus, is associated with several lymphoproliferative disorders, including Burkitt lymphoma, Hodgkin disease, diffuse large B-cell lymphoma (DLBCL), and posttransplant lymphoproliferative disorder (PTLD). In vitro, EBV transforms primary B cells into lymphoblastoid cell lines (LCLs). Recently, several studies have shown that receptor tyrosine kinases (RTKs) play important roles in EBV-associated neoplasia. However, details of the involvement of RTKs in EBV-regulated B-cell neoplasia and malignancies remain largely unclear...
September 22, 2016: Blood
https://www.readbyqxmd.com/read/27221931/epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma-is-it-different-between-over-and-under-50-years-of-age
#14
Ahmad Monabati, Amir Vahedi, Akbar Safaei, Sadat Noori, Maral Mokhtari, Leila Vahedi, Mehdi Zamani
BACKGROUND: Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) of the elderly is an entity introduced in the latest WHO classification of lymphoid tumors and defined in patients older than 50 years without prior lymphoma or immunodeficiency. However, recently it has also been seen in patients under 50. There is thus debate as to whether these are separate entities. MATERIALS AND METHODS: In this retrospective study, we analyzed de novo DLBCL admitted to our institute over a period of two years...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27170210/epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma-arising-from-a-chronic-lymphocytic-leukemia-overlapping-features-with-classical-hodgkin-lymphoma
#15
Yun-An Chen, Ran-Ching Wang, Youngsen Yang, Shih-Sung Chuang
A small proportion of patients with chronic lymphocytic leukemia (CLL) may progress to large cell lymphoma, or Richter syndrome (RS). The large cells of RS may arise through transformation of the original CLL clone (clonally related) or represent a new neoplasm (clonally unrelated), which might be Epstein-Barr virus (EBV)-associated. We present a 61-year-old male with 5-year history of CLL who developed RS on bilateral adrenal glands. The tumor showed a vague nodular growth pattern separated by thick fibrous bands and the tumor cells were large and pleomorphic, with focal sheet-like growth pattern, in a background of small B and T-lymphocytes...
July 2016: Pathology International
https://www.readbyqxmd.com/read/27169448/-discordant-lymphoma-of-duodenal-ebv-positive-peripheral-t-cell-lymphoma-not-otherwise-specified-and-ileal-diffuse-large-b-cell-lymphoma
#16
Taro Kurihara, Masahiko Sumi, Hiroko Kaiume, Wataru Takeda, Takehiko Kirihara, Keijiro Sato, Toshimitsu Ueki, Yuki Hiroshima, Mayumi Ueno, Naoaki Ichikawa, Naoko Asano, Masahide Watanabe, Hikaru Kobayashi
A 79-year-old woman was admitted with a 5-kg weight loss and anorexia. Computed tomography showed diffuse lymphadenopathy, and thickening of the duodenal and ileal walls. The patient then underwent biopsy of these sites. Pathological examination revealed duodenal Epstein-Barr virus (EBV)-positive peripheral T cell lymphoma-not otherwise specified (PTCL-NOS) and EBV-negative ileal diffuse large B-cell lymphoma (DLBCL) to be present simultaneously. Combination chemotherapy including rituximab produced a reduction of the duodenal EBV-positive PTCL-NOS lesion, but had no effect on the EBV-negative ileal DLBCL lesion...
April 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27122390/age-and-cellular-composition-influence-overall-survival-in-a-collective-of-non-immunocompromised-patients-with-ebv-positive-diffuse-large-b-cell-lymphoma-from-a-german-lymphoma-center
#17
Korinna Jöhrens, Ralf Ulrich Trappe, Dido Lenze, Michael Pfreundschuh, Marita Ziepert, Michael Hummel, Ioannis Anagnostopoulos
We investigated 41 diffuse large B-cell lymphomas (DLBCL) diagnosed at one center harboring ≥50% of latently Epstein-Barr virus (EBV)-infected neoplastic cells occurring in 34 patients aged ≥50 years and in 7 patients younger than 50 years in the absence of any known immunodeficiency for the expression patterns of EBV latent and immediate-early proteins, for the differentiation stage of the neoplastic cells, the presence of cytogenetic alterations and a possible co-infection with the human herpes virus (HHV)-8...
April 27, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27093913/ebv-positive-diffuse-large-b-cell-lymphoma-of-the-elderly-2016-update-on-diagnosis-risk-stratification-and-management
#18
REVIEW
Jorge J Castillo, Brady E Beltran, Roberto N Miranda, Ken H Young, Julio C Chavez, Eduardo M Sotomayor
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly is a provisional entity included in the 2008 WHO classification of lymphoid neoplasms. It is a disease typically seen in the elderly and thought to be associated with chronic EBV infection and severe immunosuppression with a component of immunosenescence. Recent research, however, has suggested that EBV-positive DLBCL can be seen in younger, immunocompetent patients. The diagnosis of EBV-positive DLBCL of the elderly is made through a careful pathological evaluation...
May 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/26884853/prevalence-and-clinicopathologic-features-of-cd30-positive-de-novo-diffuse-large-b-cell-lymphoma-in-chinese-patients-a-retrospective-study-of-232-cases
#19
Qi-Xing Gong, Ting-Xun Lu, Chong Liu, Zhen Wang, Jin-Hua Liang, Wei Xu, Jian-Yong Li, Zhi-Hong Zhang, Qi Chen
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease that great efforts had been made in to build up molecular and immunophenotypic subgroups that could relatively accurate indicate prognosis and give clue to therapy. Recently, CD30 was reported as a useful predictor with favorable clinical outcome. However, CD30 expression patterns and the clinicopathologic features of CD30 positive DLBCL are not well described thus far, especially in Asian patients. Here, we studied 232 cases of de novo DLBCL in East China to investigate the prevalence and clinicopathological features of CD30-positive DLBCL using a panel of immunohistochemical markers...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26861096/-pathogenesis-and-novel-therapy-for-ebv-related-b-cell-lymphoma
#20
REVIEW
Ai Sato, Natsuko Yamakawa, Ai Kotani
Epstein-Barr virus (EBV), a type of γ-herpes virus, is known to be a tumor virus. About 90% of adults were found to be persistently infected with EBV and this infection is responsible for Burkitt lymphoma (BL), extranodal NK/T cell lymphoma, Hodgkin lymphoma (HL), acquired Immune deficiency syndrome (AIDS)-associated lymphoma, and a portion of diffuse large B cell lymphomas (DLBCL). EBV-positive DLBCL in the elderly, a disease recognized in Japan, is described in the WHO classification as a new category of DLBCLs...
January 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
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