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https://www.readbyqxmd.com/read/29775977/-rehabilitation-after-traumatic-fracture-of-thoracic-and-lumbar-spine
#1
Hartmut Bork, Stefan Simmel, Eckhardt Böhle, Ulrich Ernst, Klaus Fischer, Bernd Fromm, Jean-Jacques Glaesener, Bernhard Greitemann, P Krause, S Panning, V Pullwitt, J Schmidt, Andreas Veihelmann, Lutz Vogt
On the basis of the S2-k guideline "Rehabilitation after traumatic fractures of the thoracic und lumbar spine without neurologic disorder", this article gives an overview of target-oriented rehabilitation of patients with minor fractures or those with column stability and unstable spinal fractures which are stabilised by surgery. To obtain early social and job related reintegration, outpatient or inpatient rehabilitation has to start immediately after treatment in hospital. Rehabilitation must be orientated towards the biopsychosocial model of ICF and has to be adapted for the patient...
May 18, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29775639/surgical-management-of-lower-urinary-tract-symptoms-attributed-to-benign-prostatic-hyperplasia-aua-guideline
#2
Harris E Foster, Michael J Barry, Philipp Dahm, Manhar C Gandhi, Steven A Kaplan, Tobias S Kohler, Lori B Lerner, Deborah J Lightner, J Kellogg Parsons, Claus G Roehrborn, Charles Welliver, Timothy J Wilt, Kevin T McVary
Purpose; Male lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is common in men and can have negative effects on quality of life (QOL). It is the hope that this Guideline becomes a reference on the effective evidence-based surgical management of LUTS/BPH. MATERIALS/METHODS: The evidence team searched Ovid MEDLINE, the Cochrane Library, and the Agency for Healthcare Research and Quality (AHRQ) database to identify studies indexed between January 2007 and September 2017...
May 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29775548/open-versus-laparoscopic-approach-for-morgagni-s-hernia-in-infants-and-children-a-systematic-review-and-meta-analysis
#3
Giuseppe Lauriti, Elke Zani-Ruttenstock, Vincenzo D Catania, Lina Antounians, Pierluigi Lelli Chiesa, Agostino Pierro, Augusto Zani
INTRODUCTION: The laparoscopic repair of Morgagni's hernia (MH) has been reported to be safe and feasible. However, it is still unclear whether laparoscopy is superior to open surgery in repairing MH. MATERIALS AND METHODS: Using a defined search strategy, three investigators independently identified all comparative studies reporting data on open and laparoscopic MH repair in patients <18 years of age. Case reports and opinion articles were excluded. Meta-analysis was conducted according to PRISMA guidelines and using RevMan 5...
May 18, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29775467/interactions-among-poverty-gender-and-health-systems-affect-women-s-participation-in-services-to-prevent-hiv-transmission-from-mother-to-child-a-causal-loop-analysis
#4
Jennifer Yourkavitch, Kristen Hassmiller Lich, Valerie L Flax, Elialilia S Okello, John Kadzandira, Anne Ruhweza Katahoire, Alister C Munthali, James C Thomas
Retention in care remains an important issue for prevention of mother-to-child transmission (PMTCT) programs according to WHO guidelines, formerly called the "Option B+" approach. The objective of this study was to examine how poverty, gender, and health system factors interact to influence women's participation in PMTCT services. We used qualitative research, literature, and hypothesized variable connections to diagram causes and effects in causal loop models. We found that many factors, including antiretroviral therapy (ART) use, service design and quality, stigma, disclosure, spouse/partner influence, decision-making autonomy, and knowledge about PMTCT, influence psychosocial health, which in turn affects women's participation in PMTCT services...
2018: PloS One
https://www.readbyqxmd.com/read/29775435/national-center-for-health-statistics-guidelines-for-analysis-of-trends
#5
Deborah D Ingram, Donald J Malec, Diane M Makuc, Deanna Kruszon-Moran, Renee M Gindi, Michael Albert, Vladislav Beresovsky, Brady E Hamilton, Julia Holmes, Jeannine Schiller, Manisha Sengupta
Many reports present analyses of trends over time based on multiple years of data from National Center for Health Statistics (NCHS) surveys and the National Vital Statistics System (NVSS). Trend analyses of NCHS data involve analytic choices that can lead to different conclusions about the trends. This report discusses issues that should be considered when conducting a time trend analysis using NCHS data and presents guidelines for making trend analysis choices. Trend analysis issues discussed include: choosing the observed time points to include in the analysis, considerations for survey data and vital records data (record level and aggregated), a general approach for conducting trend analyses, assorted other analytic issues, and joinpoint regression...
April 2018: Vital and Health Statistics. Series 2, Data Evaluation and Methods Research
https://www.readbyqxmd.com/read/29775322/prediction-of-human-cytochrome-p450-inhibition-using-a-multi-task-deep-autoencoder-neural-network
#6
Xiang Li, Youjun Xu, Luhua Lai, Jianfeng Pei
Adverse side effects of drug-drug interactions induced by human cytochrome P450 (CYP450) inhibition is an important consideration in drug discovery. It is highly desirable to develop computational models that can predict the inhibitive effect of a compound against a specific CYP450 isoform. In this study, we developed a multi-task model for concurrent inhibition prediction of five major CYP450 isoforms, namely 1A2, 2C9, 2C19, 2D6, and 3A4. The model was built by training multi-task autoencoder deep neural network (DNN) on a large dataset containing more than 13000 compounds, extracted from PubChem BioAssay Database...
May 18, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29775220/cystatin-c-is-a-more-reliable-biomarker-for-determining-egfr-to-support-drug-development-studies
#7
REVIEW
Sumit Kar, Sabina Paglialunga, Rafiqul Islam
Glomerular filtration rate (GFR) is routinely used as a surrogate endpoint for the development of investigational drugs in clinical trials. GFR and staging of chronic kidney disease are typically assessed by measuring the concentration of endogenous serum biomarkers such as albumin and creatinine. However, creatinine is subject to high biological variability, and levels of creatinine do not rise until nearly 50% of kidney function is damaged, leading to inaccurate chronic kidney disease staging and false negatives...
May 18, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29775201/tacrolimus-population-pharmacokinetics-and-multiple-cyp3a5-genotypes-in-black-and-white-renal-transplant-recipients
#8
Olivia Campagne, Donald E Mager, Daniel Brazeau, Rocco C Venuto, Kathleen M Tornatore
Tacrolimus exhibits inter-patient pharmacokinetic variability attributed to CYP3A5 isoenzymes and the efflux transporter, P-glycoprotein. Most black renal transplant recipients require higher tacrolimus doses compared to whites to achieve similar troughs when race-adjusted recommendations are used. An established guideline provides tacrolimus genotype dosing recommendations based on CYP3A5*1(W/T) and loss of protein function variants: CYP3A5*3 (rs776746), CYP3A5*6 (rs10264272), CYP3A5*7 (rs41303343) and may provide more comprehensive race-adjusted dosing recommendations...
May 18, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29775170/rationale-design-and-protocol-of-a-randomized-controlled-trial-of-the-safety-and-efficacy-of-dabigatran-etexilate-versus-dose-adjusted-warfarin-in-patients-with-cerebral-venous-thrombosis
#9
José M Ferro, Francesco Dentali, Jonathan M Coutinho, Adam Kobayashi, Jorge Caria, Marc Desch, Mandy Fraessdorf, Holger Huisman, Hans-Christoph Diener
Rationale To prevent recurrent venous thrombotic events after acute cerebral venous or dural sinus thrombosis, guidelines recommend long-term oral anticoagulation with vitamin K antagonists. Non-vitamin K oral anticoagulant experience in cerebral venous or dural sinus thrombosis is limited to case reports and series. Aim To compare dabigatran with dose-adjusted warfarin in patients with cerebral venous or dural sinus thrombosis for the prevention of recurrent venous thrombotic event. Sample size One hundred and twenty patients...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29775118/blood-flow-restricted-resistance-training-in-patients-with-sporadic-inclusion-body-myositis-a-randomized-controlled-trial
#10
A N Jørgensen, P Aagaard, U Frandsen, E Boyle, L P Diederichsen
OBJECTIVES: To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM). METHOD: Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week...
May 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29775090/evaluation-of-management-and-guideline-adherence-in-children-with-mild-traumatic-brain-injury
#11
Merel C Broers, Jikke-Mien F Niermeijer, Irene A W Kotsopoulos, Hester F Lingsma, Jos F M Bruinenberg, Coriene E Catsman-Berrevoets
AIM: To evaluate the management and guideline adherence in children with mild traumatic brain injury (MTBI) in emergency departments (ED) in the Netherlands. METHODS: A multicentre cohort study was conducted, including children younger than 18 years with MTBI who presented within 24 hours after trauma in the ED of hospitals in the southwest region of the Netherlands, in 2014. Primary outcome measures for management were percentages of performed computed tomography (CT) scans and hospital admissions...
May 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29775077/evaluating-the-influence-of-road-lighting-on-traffic-safety-at-accesses-using-an-artificial-neural-network
#12
Yueru Xu, Zhirui Ye, Yuan Wang, Chao Wang, Cuicui Sun
OBJECTIVES: This paper focuses on the effect of road lighting on road safety at accesses and tries to quantitatively analyze the relationship between road lighting and road safety. METHODS: An Artificial Neural Network (ANN) was applied in this study. This method is one of the most popular machine-learning methods in recent years and does not require any pre-defined assumptions. This method was applied using field data collected from ten road segments in Nanjing, Jiangsu Province, China...
May 18, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29775033/guidelines-for-clinical-practice-hymenoptera-sting-allergy-in-children-2017-update
#13
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29774988/differences-in-primary-cardiovascular-disease-prevention-between-the-2013-and-2016-cholesterol-guidelines-and-impact-of-the-2017-hypertension-guideline-in-the-united-states
#14
Brent M Egan, Jiexiang Li, Robert A Davis, Kevin A Fiscella, Jonathan N Tobin, Daniel W Jones, Angelo Sinopoli
The US Preventive Services Task Force cholesterol guideline recommended statins for fewer adults than the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline by setting a higher 10-year atherosclerotic cardiovascular disease threshold (≥10.0% vs ≥7.5%) and requiring concomitant diabetes mellitus, hypertension, dyslipidemia, or cigarette smoking. The 2017 ACC/AHA hypertension guideline lowered the hypertension threshold, increasing 2016 guideline statin-eligible adults. Cross-sectional data on US adults aged 40 to 75 years enabled estimated numbers for the 2013 guideline and 2016 guideline with hypertension thresholds of ≥140/≥90 mm Hg and ≥130/80 mm Hg, respectively, on: (1) untreated, statin-eligible adults for primary atherosclerotic cardiovascular disease prevention (25...
May 18, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29774895/rational-design-of-a-neutral-ph-functional-and-stable-organic-photocathode
#15
Laia Francàs, Eric Burns, Ludmilla Steier, Hyojung Cha, Lluís Solà-Hernández, Xiaoe Li, Pabitra Shakya Tuladhar, Roger Bofill, Jordi García-Antón, Xavier Sala, James R Durrant
In this work we lay out design guidelines for catalytically more efficient organic photocathodes achieving stable hydrogen production in neutral pH. We propose an organic photocathode architecture employing a NiO hole selective layer, a PCDTBT:PCBM bulk heterojunction, a compact TiO2 electron selective contact and a RuO2 nanoparticle catalyst. The role of each layer is discussed in terms of durability and function. With this strategically designed organic photocathode we obtain stable photocurrent densities for over 5 h and discuss routes for further performance improvement...
May 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29774824/technique-of-percutaneous-nephrolithotomy
#16
Ahmed Ibrahim, Daniel Wollin, Glenn Preminger, Sero Andonian
According to the latest American and European Urological Association guidelines, percutaneous nephrolithotomy (PNL) is the current gold standard treatment for patients presenting with symptomatic large or complex renal stones ≥2 cm. This review chapter and accompanying videos will review the latest literature on indications, preoperative preparations, different patient positions, in addition to step by step explanations for the technique of PNL. Postoperative care and troubleshooting tips are provided. Furthermore, latest reported outcomes are reviewed...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29774777/current-research-status-of-palliative-care-in-mainland-china
#17
Tao Wang, Alex Molassiotis, Betty Pui Man Chung, Jing-Yu Tan
OBJECTIVES: This study aimed to obtain an overview of the current research status of palliative care in Mainland China and identify research directions for future studies by characterizing palliative care studies conducted among patients with any life-limiting illness in Mainland China and published in a peer-reviewed journal before November 2016. METHODS: A review guide with 7 categories was initially developed based on existing international palliative care definitions and guidelines through content analysis...
January 1, 2018: Journal of Palliative Care
https://www.readbyqxmd.com/read/29774760/safety-of-nonsteroidal-anti-inflammatory-drugs-in-copperhead-snakebite-patients
#18
Hoang X Pham, Michael E Mullins
INTRODUCTION: Current management guidelines for pit viper envenomations recommend against the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for pain control due to concern for platelet dysfunction and resulting coagulopathy. However, prior research suggests that copperhead snakes generally do not cause coagulopathy and they are responsible for most of the venomous snakebites in the USA. Thus, we compared the occurrences of clinically apparent bleeding and most abnormal laboratory values of coagulation between copperhead envenomation patients who received NSAIDs and those who did not...
May 18, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29774612/elastic-fiber-supercapacitors-for-wearable-energy-storage
#19
REVIEW
Si Qin, Shayan Seyedin, Jizhen Zhang, Zhiyu Wang, Fangli Yang, Yuqing Liu, Jun Chen, Joselito M Razal
The development of wearable devices such as smart watches, intelligent garments, and wearable health-monitoring devices calls for suitable energy storage devices which have matching mechanical properties and can provide sufficient power for a reasonable duration. Stretchable fiber-based supercapacitors are emerging as a promising candidates for this purpose because they are lightweight, flexible, have high energy and power density, and the potential for easy integration into traditional textile processes. An important characteristic that is oftentimes ignored is stretchability-fiber supercapacitors should be able to accommodate large elongation during use, endure a range of bending motions, and then revert to its original form without compromising electrical and electrochemical performance...
May 17, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29774538/oral-propranolol-in-the-treatment-of-proliferating-infantile-haemangiomas-the-british-society-for-paediatric-dermatology-consensus-guidelines
#20
L Solman, M Glover, P E Beattie, H Buckley, S Clark, J E Gach, A Giardini, I Helbling, R J Hewitt, B Laguda, S M Langan, A E Martinez, R Murphy, L Proudfoot, J Ravenscroft, H Shahidullah, L Shaw, S B Syed, L Wells, C Flohr
BACKGROUND: Infantile haemangiomas (IH) are the most common vascular tumours of infancy. Despite their frequency and potential complications, there are currently no unified UK guidelines for the treatment of IH with propranolol. There are still uncertainties and diverse opinions regarding indications, pre-treatment investigations, its use in PHACES syndrome, and cessation of treatment. METHODS: This study used a modified Delphi technique, which involved an international treatment survey, a systematic evidence review of the literature, a face-to-face multidisciplinary panel meeting and anonymous voting...
May 17, 2018: British Journal of Dermatology
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