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https://www.readbyqxmd.com/read/29337571/direct-observation-of-a-transiently-formed-isomer-during-iodoform-photolysis-in-solution-by-time-resolved-x-ray-liquidography
#1
Chi Woo Ahn, Hosung Ki, Joonghan Kim, Jeongho Kim, Sungjun Park, Yunbeom Lee, Kyung Hwan Kim, Qingyu Kong, Jiwon Moon, Martin Nors Pedersen, Michael Wulff, Hyotcherl Ihee
Photolysis of iodoform (CHI3) in solution has been extensively studied but its reaction mechanism remains elusive. In particular, iso-iodoform (iso-CHI2-I) is formed as a product of the photolysis reaction, but its detailed structure is not known and whether it is a major intermediate species has been controversial. Here, by using time-resolved X-ray liquidography, we determined the reaction mechanism of CHI3 photodissociation in cyclohexane as well as the structure of iso-CHI2-I. Both iso-CHI2-I and CHI2 radical were found to be formed within 100 ps with a branching ratio of 40:60...
January 16, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29320942/campus-sexual-assault-future-directions-for-research
#2
Sarah McMahon, Leila Wood, Julia Cusano, Lisa M Macri
Campus sexual assault (CSA) has received unprecedented attention over recent years, resulting in an abundance of federal guidance and mandates. In response, efforts to address and prevent CSA at Institutions of Higher Education (IHE) across the country have grown quickly, including the development and implementation of programs and policies. Because the changes on campuses have occurred at such a rapid pace, a number of gaps exist within the field of CSA research. To ensure that changes on IHE are evidence-based, there is a need to review the existing research available and the inquiry still needed, based on key areas outlined in federal guidance, the expressed needs of campus community members, survivors, and students who commit sexual offenses on college campuses...
January 1, 2018: Sexual Abuse: a Journal of Research and Treatment
https://www.readbyqxmd.com/read/29282752/self-gated-golden-angle-spiral-cine-mri-for-coronary-endothelial-function-assessment
#3
Gabriele Bonanno, Allison G Hays, Robert G Weiss, Michael Schär
PURPOSE: Depressed coronary endothelial function (CEF) is a marker for atherosclerotic disease, an independent predictor of cardiovascular events, and can be quantified non-invasively with ECG-triggered spiral cine MRI combined with isometric handgrip exercise (IHE). However, MRI-CEF measures can be hindered by faulty ECG-triggering, leading to prolonged breath-holds and degraded image quality. Here, a self-gated golden angle spiral method (SG-GA) is proposed to eliminate the need for ECG during cine MRI...
December 27, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29247511/isometric-handgrip-echocardiography-a-noninvasive-stress-test-to-assess-left-ventricular-diastolic-function
#4
T Jake Samuel, Rhys Beaudry, Mark J Haykowsky, Satyam Sarma, Suwon Park, Thomas Dombrowsky, Paul S Bhella, Michael D Nelson
BACKGROUND: Cycle exercise echocardiography is a useful tool to "unmask" diastolic dysfunction; however, this approach can be limited by respiratory and movement artifacts. Isometric handgrip avoids these issues while reproducibly increasing afterload and myocardial oxygen demand. HYPOTHESIS: Isometric handgrip echocardiography (IHE) can differentiate normal from abnormal diastolic function. METHODS: First recruited 19 young healthy individuals (mean age, 24 ± 4 years) to establish the "normal" response...
December 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29100252/guidelines-regarding-%C3%A2-16-of-the-german-transplantation-act-initial-experiences-with-structured-reporting
#5
Daniel Pinto Dos Santos, Gordon Arnhold, Peter Mildenberger, Christoph Düber, Roman Kloeckner
Purpose To transfer the report sheet from the guidelines regarding the German Transplantation Act to a standards-compliant report template and to evaluate it in the clinical routine. Materials and Methods The template was developed using the freely available software brackets.io. It was implemented in the clinical routine using a reporting platform developed in-house. Interfaces to the department RIS and PACS allowed for integration into the usual reporting workflow. The evaluation period was 70 days. Results Developing the template for implementation of the guidelines was possible without any difficulties...
December 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29073168/coronary-endothelial-function-is-better-in-healthy-premenopausal-women-than-in-healthy-older-postmenopausal-women-and-men
#6
Lena Mathews, Micaela Iantorno, Michael Schär, Gabriele Bonanno, Gary Gerstenblith, Robert G Weiss, Allison G Hays
BACKGROUND: Premenopausal women have fewer cardiovascular disease (CVD) events than postmenopausal women and age-matched men, but the reasons are not fully understood. Coronary endothelial function (CEF), a barometer of coronary vascular health, promises important insights into age and sex differences in atherosclerotic CVD risk, but has not been well characterized in healthy individuals because of the invasive nature of conventional CEF measurements. Recently developed magnetic resonance imaging (MRI) methods were used to quantify CEF (coronary area and flow changes in response to isometric handgrip exercise (IHE), an endothelial-dependent stressor) to test the hypothesis that healthy women have better CEF compared to men particularly at a younger age...
2017: PloS One
https://www.readbyqxmd.com/read/28970412/exploration-of-learning-during-an-international-health-elective-using-photovoice-methodology
#7
Amy Werremeyer, Elizabeth Skoy, Gina Aalgaard Kelly
Based on surveys and structured interviews, International Health Experiences (IHEs) improve cultural sensitivity, communication, and self-confidence among health professions students. However, open-ended methods to explore student learning during an IHE are not widely utilized. We sought to explore pharmacy student-identified learning during an IHE in an open-ended fashion using Photovoice methodology. Pharmacy students on an IHE in Guatemala were given disposable cameras and asked to photograph images that reflected their learning...
November 29, 2016: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28846046/the-use-of-simulated-altitude-techniques-for-beneficial-cardiovascular-health-outcomes-in-nonathletic-sedentary-and-clinical-populations-a-literature-review
#8
Catherine A Lizamore, Michael J Hamlin
Lizamore, Catherine A., and Michael J. Hamlin. The use of simulated altitude techniques for beneficial cardiovascular health outcomes in nonathletic, sedentary, and clinical populations: A literature review. High Alt Med Biol 00:000-000, 2017. BACKGROUND: The reportedly beneficial improvements in an athlete's physical performance following altitude training may have merit for individuals struggling to meet physical activity guidelines. AIM: To review the effectiveness of simulated altitude training methodologies at improving cardiovascular health in sedentary and clinical cohorts...
August 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28837211/special-topic-interoperability-and-ehr-combining-openehr-snomed-ihe-and-continua-as-approaches-to-interoperability-on-national-ehealth
#9
Mate Beštek, Dalibor Stanimirović
OBJECTIVES: The main aims of the paper comprise the characterization and examination of the potential approaches regarding interoperability. This includes openEHR, SNOMED, IHE, and Continua as combined interoperability approaches, possibilities for their incorporation into the eHealth environment, and identification of the main success factors in the field, which are necessary for achieving required interoperability, and consequently, for the successful implementation of eHealth projects in general...
August 9, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28796600/interoperable-end-to-end-remote-patient-monitoring-platform-based-on-ieee-11073-phd-and-zigbee-health-care-profile
#10
Malcolm Clarke, Joost de Folter, Vivek Verma, Hulya Gokalp
This paper describes the implementation of an end-to-end remote monitoring platform based on the IEEE 11073 standards for Personal Health Devices (PHD). It provides an overview of the concepts and approaches and describes how the standard has been optimized for small devices with limited resources of processor, memory and power and that use short range wireless technology. It explains aspects of IEEE 11073, including the Domain Information Model, state model and nomenclature, and how these support its plug-and-play architecture...
August 7, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28679397/local-coronary-wall-eccentricity-and-endothelial-function-are-closely-related-in-patients-with-atherosclerotic-coronary-artery-disease
#11
Allison G Hays, Micaela Iantorno, Michael Schär, Monica Mukherjee, Matthias Stuber, Gary Gerstenblith, Robert G Weiss
BACKGROUND: Coronary endothelial function (CEF) in patients with coronary artery disease (CAD) varies among coronary segments in a given patient. Because both coronary vessel wall eccentricity and coronary endothelial dysfunction are predictors of adverse outcomes, we hypothesized that local coronary endothelial dysfunction is associated with local coronary artery eccentricity. METHODS: We used 3 T coronary CMR to measure CEF as changes in coronary cross-sectional area (CSA) and coronary blood flow (CBF) during isometric handgrip exercise (IHE), a known endothelial-dependent stressor, in 29 patients with known CAD and 16 healthy subjects...
July 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28601027/a-semantic-interoperability-approach-to-support-integration-of-gene-expression-and-clinical-data-in-breast-cancer
#12
Raul Alonso-Calvo, Sergio Paraiso-Medina, David Perez-Rey, Enrique Alonso-Oset, Ruud van Stiphout, Sheng Yu, Marian Taylor, Francesca Buffa, Carlos Fernandez-Lozano, Alejandro Pazos, Victor Maojo
INTRODUCTION: The introduction of omics data and advances in technologies involved in clinical treatment has led to a broad range of approaches to represent clinical information. Within this context, patient stratification across health institutions due to omic profiling presents a complex scenario to carry out multi-center clinical trials. METHODS: This paper presents a standards-based approach to ensure semantic integration required to facilitate the analysis of clinico-genomic clinical trials...
August 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28514150/correction-to-photocycle-of-photoactive-yellow-protein-in-cell-mimetic-environments-molecular-volume-changes-and-kinetics
#13
Cheolhee Yang, Seong Ok Kim, Yonggwan Kim, So Ri Yun, Jungkweon Choi, Hyotcherl Ihee
No abstract text is available yet for this article.
May 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28508818/biosignals-standards-and-fhir-the-way-to-go
#14
Stefan Sauermann, Veronika David, Alois Schlögl, Reinhard Egelkraut, Matthias Frohner, Birgit Pohn, Philipp Urbauer, Alexander Mense
BACKGROUND: Standards have become available to share semantically encoded vital parameters from medical devices, as required for example by personal healthcare records. Standardised sharing of biosignal data largely remains open. OBJECTIVES: The goal of this work is to explore available biosignal file format and data exchange standards and profiles, and to conceptualise end-to-end solutions. METHODS: The authors reviewed and discussed available biosignal file format standards with other members of international standards development organisations (SDOs)...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28479549/patient-summaries-in-context-of-large-scale-ehr-networks-with-fine-granular-access-control-restrictions
#15
Patrick Mangesius, Samrend Saboor, Thomas Schabetsberger
BACKGROUND: Large Scale Electronic Health Record (EHR) systems tend to contain a significant higher amount of patient data compared to traditional local Electronic Medical Record (EMR) silos. This demands the requirement of providing a user context and role specific summary of the patient record. Security and Access Control systems are a crucial part of modern EHR systems controlling legal policies and patient consents. Goal of this paper is to elaborate a concept enhancing an already existing, commonly based on IHE XDS and XACML based, EHR systems with summarization functionalities...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28405591/svd-aided-pseudo-principal-component-analysis-a-new-method-to-speed-up-and-improve-determination-of-the-optimum-kinetic-model-from-time-resolved-data
#16
Key Young Oang, Cheolhee Yang, Srinivasan Muniyappan, Jeongho Kim, Hyotcherl Ihee
Determination of the optimum kinetic model is an essential prerequisite for characterizing dynamics and mechanism of a reaction. Here, we propose a simple method, termed as singular value decomposition-aided pseudo principal-component analysis (SAPPA), to facilitate determination of the optimum kinetic model from time-resolved data by bypassing any need to examine candidate kinetic models. We demonstrate the wide applicability of SAPPA by examining three different sets of experimental time-resolved data and show that SAPPA can efficiently determine the optimum kinetic model...
July 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28375690/ultrafast-x-ray-crystallography-and-liquidography
#17
Hosung Ki, Key Young Oang, Jeongho Kim, Hyotcherl Ihee
Time-resolved X-ray diffraction provides direct information on three-dimensional structures of reacting molecules and thus can be used to elucidate structural dynamics of chemical and biological reactions. In this review, we discuss time-resolved X-ray diffraction on small molecules and proteins with particular emphasis on its application to crystalline (crystallography) and liquid-solution (liquidography) samples. Time-resolved X-ray diffraction has been used to study picosecond and slower dynamics at synchrotrons and can now access even femtosecond dynamics with the recent arrival of X-ray free-electron lasers...
May 5, 2017: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/28364029/intact-blood-pressure-but-not-sympathetic-responsiveness-to-sympathoexcitatory-stimuli-in-a-patient-with-unilateral-carotid-body-resection
#18
Kathryn F Larson, Jacqueline K Limberg, Sarah E Baker, Michael J Joyner, Timothy B Curry
Despite rapidly growing interest in the therapeutic resection of the carotid body (CB) chemoreceptors, few physiologic studies exist on the consequences of unilateral CB resection. We present a case of an otherwise healthy postmenopausal female who underwent unilateral CB resection for a paraganglioma. Approximately 4 years postoperatively, she underwent analysis of her sympathetic and hemodynamic responses to hypoxia, lower body negative pressure, cold pressor test (CPT), and ischemic hand grip exercise and postexercise ischemia (IHE/PEI)...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28353539/coronary-artery-endothelial-dysfunction-is-present-in-hiv-positive-individuals-without-significant-coronary-artery-disease
#19
Micaela Iantorno, Michael Schär, Sahar Soleimanifard, Todd T Brown, Richard Moore, Patricia Barditch-Crovo, Matthias Stuber, Shenghan Lai, Gary Gerstenblith, Robert G Weiss, Allison G Hays
OBJECTIVE: HIV-positive (HIV+) individuals experience an increased burden of coronary artery disease (CAD) not adequately accounted for by traditional CAD risk factors. Coronary endothelial function (CEF), a barometer of vascular health, is depressed early in atherosclerosis and predict future events but has not been studied in HIV+ individuals. We tested whether CEF is impaired in HIV+ patients without CAD as compared with an HIV-negative (HIV-) population matched for cardiac risk factors...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28255789/-incidental-findings-evaluation-management-recommendations-and-legal-considerations
#20
P Mildenberger
Incidental findings are part of the routine radiological reporting workflow and describe findings which are not primarily the focus of the clinical context or the request of the referring physician. The clinical implications of such incidental findings can be very different, for example simple renal cysts or space-occupying lesions suspected of being tumors. A categorization of clinical findings according to the clinical relevance is therefore recommended. Documentation and communication of clinically relevant incidental findings are a part of the radiological reporting process and essential for reduction of the medicolegal risk...
April 2017: Der Radiologe
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