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https://www.readbyqxmd.com/read/28405591/svd-aided-pseudo-principal-component-analysis-a-new-method-to-speed-up-and-improve-determination-of-the-optimum-kinetic-model-from-time-resolved-data
#1
Key Young Oang, Cheolhee Yang, Srinivasan Muniyappan, Jeongho Kim, Hyotcherl Ihee
Determination of the optimum kinetic model is an essential prerequisite for characterizing dynamics and mechanism of a reaction. Here, we propose a simple method, termed as singular value decomposition-aided pseudo principal-component analysis (SAPPA), to facilitate determination of the optimum kinetic model from time-resolved data by bypassing any need to examine candidate kinetic models. We demonstrate the wide applicability of SAPPA by examining three different sets of experimental time-resolved data and show that SAPPA can efficiently determine the optimum kinetic model...
July 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28375690/ultrafast-x-ray-crystallography-and-liquidography
#2
Hosung Ki, Key Young Oang, Jeongho Kim, Hyotcherl Ihee
Time-resolved X-ray diffraction provides direct information on three-dimensional structures of reacting molecules and thus can be used to elucidate structural dynamics of chemical and biological reactions. In this review, we discuss time-resolved X-ray diffraction on small molecules and proteins with particular emphasis on its application to crystalline (crystallography) and liquid-solution (liquidography) samples. Time-resolved X-ray diffraction has been used to study picosecond and slower dynamics at synchrotrons and can now access even femtosecond dynamics with the recent arrival of X-ray free-electron lasers...
March 27, 2017: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/28364029/intact-blood-pressure-but-not-sympathetic-responsiveness-to-sympathoexcitatory-stimuli-in-a-patient-with-unilateral-carotid-body-resection
#3
Kathryn F Larson, Jacqueline K Limberg, Sarah E Baker, Michael J Joyner, Timothy B Curry
Despite rapidly growing interest in the therapeutic resection of the carotid body (CB) chemoreceptors, few physiologic studies exist on the consequences of unilateral CB resection. We present a case of an otherwise healthy postmenopausal female who underwent unilateral CB resection for a paraganglioma. Approximately 4 years postoperatively, she underwent analysis of her sympathetic and hemodynamic responses to hypoxia, lower body negative pressure, cold pressor test (CPT), and ischemic hand grip exercise and postexercise ischemia (IHE/PEI)...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28353539/coronary-artery-endothelial-dysfunction-is-present-in-hiv-positive-individuals-without-significant-coronary-artery-disease
#4
Micaela Iantorno, Michael Schär, Sahar Soleimanifard, Todd T Brown, Richard Moore, Patricia Barditch-Crovo, Matthias Stuber, Shenghan Lai, Gary Gerstenblith, Robert G Weiss, Allison G Hays
OBJECTIVE: HIV+ individuals experience an increased burden of coronary artery disease (CAD) not adequately accounted for by traditional CAD risk factors. Coronary endothelial function (CEF), a barometer of vascular health, is depressed early in atherosclerosis and predicts future events but has not been studied in HIV+ individuals. We tested whether CEF is impaired in HIV+ subjects without CAD as compared to an HIV- population matched for cardiac risk factors. DESIGN/METHODS: In this observational study, CEF was measured noninvasively by quantifying isometric handgrip exercise (IHE)-induced changes in coronary vasoreactivity with MRI in 18 participants with HIV but no CAD (HIV+CAD-, based on prior imaging), 36 age- and cardiac risk factor-matched healthy participants with neither HIV nor CAD (HIV-CAD-), 41 subjects with no HIV but with known CAD (HIV-CAD+) and 17 subjects with both HIV and CAD (HIV+CAD+)...
March 28, 2017: AIDS
https://www.readbyqxmd.com/read/28255789/-incidental-findings-evaluation-management-recommendations-and-legal-considerations
#5
P Mildenberger
Incidental findings are part of the routine radiological reporting workflow and describe findings which are not primarily the focus of the clinical context or the request of the referring physician. The clinical implications of such incidental findings can be very different, for example simple renal cysts or space-occupying lesions suspected of being tumors. A categorization of clinical findings according to the clinical relevance is therefore recommended. Documentation and communication of clinically relevant incidental findings are a part of the radiological reporting process and essential for reduction of the medicolegal risk...
March 2, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28210482/delayed-interval-delivery-can-save-the-second-twin-evidence-from-a-systematic-review
#6
REVIEW
S Feys, Y Jacquemyn
BACKGROUND: In case of preterm birth in twins, it is not well established if the second twin benefits from a delayed-interval delivery. OBJECTIVE: The main objective of this systematic review is to evaluate survival benefit of the second twin from delayed interval delivery compared to the first twin. Secondly, we will evaluate the survival benefit of the procedure when performed equal to or after 24 weeks gestational age of the first born. METHODS: Delayed interval delivery was defined as every attempt to perform a delayed interval delivery with at minimum placement of a high ligature of the umbilical cord and a delay of delivery of at least 24 hours...
December 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28193464/igas-a-framework-for-using-electronic-intraoperative-medical-records-for-genomic-discovery
#7
Matthew A Levin, Thomas T Joseph, Janina M Jeff, Rajiv Nadukuru, Stephen B Ellis, Erwin P Bottinger, Eimear E Kenny
OBJECTIVE: Design and implement a HIPAA and Integrating the Healthcare Enterprise (IHE) profile compliant automated pipeline, the integrated Genomics Anesthesia System (iGAS), linking genomic data from the Mount Sinai Health System (MSHS) BioMe biobank to electronic anesthesia records, including physiological data collected during the perioperative period. The resulting repository of multi-dimensional data can be used for precision medicine analysis of physiological readouts, acute medical conditions, and adverse events that can occur during surgery...
February 10, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28131837/acute-improvement-of-endothelial-functions-after-oral-ingestion-of-isohumulones-bitter-components-of-beer
#8
Junko Tomita, Seiichi Mochizuki, Sohachi Fujimoto, Naoki Kashihara, Takashi Akasaka, Mitsune Tanimoto, Kiyoshi Yoshida
Isohumulones, principal components of the bitter taste of beers, have antioxidant capacity. We studied i) the effects of oral ingestion of isomerized hop extract (IHE) on the endothelial functions in smokers as well as non-smokers and ii) the effects of IHE on cultured endothelial cells in high oxidative stress state. Twelve cigarette smokers and eleven non-smokers ingested IHE and placebo in a randomized crossover design. Flow-mediated vasodilatation (FMD) was measured using ultrasonography. We also studied the effects of isohumulones on i) the cell viability under hypoxia and ii) the levels of angiotensin II (AT-II)-induced reactive oxygen species (ROS) in the cultured human aortic endothelial cells (HAECs)...
January 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28063135/cost-effectiveness-of-insulin-degludec-plus-liraglutide-ideglira-in-a-fixed-combination-for-uncontrolled-type-2-diabetes-mellitus-in-sweden
#9
Åsa Ericsson, Adam Lundqvist
BACKGROUND: Patients with uncontrolled type 2 diabetes mellitus (T2DM) are a priority group for intensified therapy without weight gain and with low risk of hypoglycaemia. OBJECTIVE: This study evaluates the cost effectiveness of insulin degludec plus liraglutide (IDegLira, Xultophy(®)) compared with six potential intensification treatment options for patients with T2DM that is uncontrolled with basal insulin. METHODS: The Swedish Institute for Health Economics (IHE) Cohort Model of Type 2 Diabetes was used with Swedish input data, a 40-year time frame and a societal perspective...
April 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28058827/photocycle-of-photoactive-yellow-protein-in-cell-mimetic-environments-molecular-volume-changes-and-kinetics
#10
Cheolhee Yang, Seong Ok Kim, Yonggwan Kim, So Ri Yun, Jungkweon Choi, Hyotcherl Ihee
Using various spectroscopic techniques such as UV-visible spectroscopy, circular dichroism spectroscopy, NMR spectroscopy, small-angle X-ray scattering, transient grating, and transient absorption techniques, we investigated how cell-mimetic environments made by crowding influence the photocycle of photoactive yellow protein (PYP) in terms of the molecular volume change and kinetics. Upon addition of molecular crowding agents, the ratio of the diffusion coefficient of the blue-shifted intermediate (pB) to that of the ground species (pG) significantly changes from 0...
January 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28048916/mo-ab-204-02-ihe-rad
#11
J Seibert
You've experienced the frustration: vendor A's device claims to work with vendor B's device, but the practice doesn't match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048268/mo-ab-204-03-profile-development-and-ihe-process
#12
C Pauer
You've experienced the frustration: vendor A's device claims to work with vendor B's device, but the practice doesn't match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047622/mo-ab-204-04-connectathons-and-testing
#13
W Bosch
You've experienced the frustration: vendor A's device claims to work with vendor B's device, but the practice doesn't match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047508/mo-ab-204-00-interoperability-in-radiation-oncology-ihe-ro-committee-update
#14
Scott Hadley
You've experienced the frustration: vendor A's device claims to work with vendor B's device, but the practice doesn't match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046852/mo-ab-204-01-ihe-ro-overview
#15
S Hadley
You've experienced the frustration: vendor A's device claims to work with vendor B's device, but the practice doesn't match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27892472/atomistic-characterization-of-the-active-site-solvation-dynamics-of-a-model-photocatalyst
#16
Tim B van Driel, Kasper S Kjær, Robert W Hartsock, Asmus O Dohn, Tobias Harlang, Matthieu Chollet, Morten Christensen, Wojciech Gawelda, Niels E Henriksen, Jong Goo Kim, Kristoffer Haldrup, Kyung Hwan Kim, Hyotcherl Ihee, Jeongho Kim, Henrik Lemke, Zheng Sun, Villy Sundström, Wenkai Zhang, Diling Zhu, Klaus B Møller, Martin M Nielsen, Kelly J Gaffney
The interactions between the reactive excited state of molecular photocatalysts and surrounding solvent dictate reaction mechanisms and pathways, but are not readily accessible to conventional optical spectroscopic techniques. Here we report an investigation of the structural and solvation dynamics following excitation of a model photocatalytic molecular system [Ir2(dimen)4](2+), where dimen is para-diisocyanomenthane. The time-dependent structural changes in this model photocatalyst, as well as the changes in the solvation shell structure, have been measured with ultrafast diffuse X-ray scattering and simulated with Born-Oppenheimer Molecular Dynamics...
November 28, 2016: Nature Communications
https://www.readbyqxmd.com/read/27661542/status-of-personal-health-requirement-for-graduation-at-institutions-of-higher-education-in-the-united-states
#17
Dayna S Henry, Nicole Aydt Klein, Monica Kempland, Sarah Rose Oswalt, Molly A Rexilius
OBJECTIVE: The purpose of this study was to examine the proportion of higher education institutions in the United States that require a personal health course (PHC) for graduation and to describe the nature of such requirements. Participants: This study included a random sample of public and private institutions of higher education (IHE) with undergraduate programs within the United States (N = 310). Data were collected between September 2014 and May 2015. METHODS: University catalogs were accessed from the institutions' public Web sites to determine whether a PHC was offered, and whether it was exclusively or optionally required for graduation...
January 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/27617583/idiopathic-hypereosinophilic-syndrome-associated-with-endomyocardial-fibrosis-intracardiac-thrombi-pulmonary-and-skin-infiltration-a-case-report
#18
Y-Q He, J-M Zhu, Y-N Zhao, L Liu, H Zeng, P Yang
Idiopathic hypereosinophilic syndrome (IHES) is a rare disease involving multiple vital organ systems. Here we present the case of a 42-year-old man who had IHES associated with simultaneously occurring endomyocardial fibrosis, thrombi, and pulmonary and skin infiltration. The patient was referred to our hospital with electrocardiographic and biochemical cardiac marker abnormalities suggesting acute coronary syndrome. The patient's condition aggravated within one month, but was greatly improved with the combination therapy of glucocorticoids, hydroxyurea, warfarin and standard treatment for heart failure...
March 10, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27584268/changes-in-aerobic-and-anaerobic-capacity-following-either-7-days-of-overnight-ihe-or-7-days-of-iht-1112-board-1-june-1-3-15-pm-5-15-pm
#19
Marie Oriishi, Masahiro Hagiwara, Ryo Yamanaka, Toshiyuki Ohya, Kazunori Asaba, Takashi Kawahara, Yasuhiro Suzuki
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27583300/global-health-simulation-during-residency
#20
Jane R Rosenman, Philip R Fischer, Grace M Arteaga, Manasi Hulyalkar, Sabrina M Butteris, Michael B Pitt
Resident participation in international health electives (IHEs) has been shown to be beneficial, yet not all residents have the opportunity to participate. We sought to determine whether participating in simulated global health cases, via the standardized Simulation Use for Global Away Rotations (SUGAR) curriculum, was useful for all pediatric residents, not merely those planning to go on an IHE. Pediatric residents in our program took part in 2 SUGAR cases and provided feedback via an online survey. Thirty-six of 40 residents participated (90%); 72% responded to the survey...
2016: Global Pediatric Health
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