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Thomas Jake Samuel, Rhys Beaudry, Mark J Haykowsky, Satyam Sarma, Michael D Nelson
BACKGROUND: Cycle echocardiography (CE) is recommended for non-invasive diagnosis of diastolic dysfunction, but can be limited by respiratory and movement artifact. Isometric handgrip echocardiography (IHE) is also a robust diastolic discriminator, while avoiding the limitations associated with dynamic exercise. This study sought to compare these two diastolic stress testing approaches. METHODS: Twelve elderly individuals were recruited from the community (age: 71 + 6 years)...
May 10, 2018: Journal of Applied Physiology
Pinto Dos Santos Daniel, Scheibl Sonja, Arnhold Gordon, Maehringer-Kunz Aline, Düber Christoph, Mildenberger Peter, Kloeckner Roman
OBJECTIVE: This paper studies the possibilities of an integrated IT-based workflow for epidemiological research in pulmonary embolism using freely available tools and structured reporting. METHODS: We included a total of 521 consecutive cases which had been referred to the radiology department for computed tomography pulmonary angiography (CTPA) with suspected pulmonary embolism (PE). Free-text reports were transformed into structured reports using a freely available IHE-MRRT-compliant reporting platform...
May 10, 2018: British Journal of Radiology
Hong Wang, Huan Zhang, Ting-Ting Qiu, Yu-Lan Peng
OBJECTIVE: To investigate the clinical manifestations and ultrasound features of hepatic infantile hemangioendothelioma (IHE). METHODS: This study retrospectively analyzed the clinical features and ultrasound characteristics of 8 patients of IHE,whose diagnosis was confirmed by surgery or liver biopsy from January 2010 to October 2016. RESULTS: Among the eight IHE patients,the male-to-female ratio was 1:1,with the mean age ranged from 15 d to 3 yr...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Jan Gaebel, Erik Schreiber, Alexander Oeser, Steffen Oeltze-Jafra
Model-based decision support systems promise to be a valuable addition to oncological treatments and the implementation of personalized therapies. For the integration and sharing of decision models, the involved systems must be able to communicate with each other. In this paper, we propose a modularized architecture of dedicated systems for the integration of probabilistic decision models into existing hospital environments. These systems interconnect via web services and provide model sharing and processing capabilities for clinical information systems...
2018: Studies in Health Technology and Informatics
Emmanuel Helm, Andreas Schuler, Herwig Mayr
BACKGROUND: The research project REPO (Radiology Ehealth PlatfOrm) was started in 2017 with the goal to "enable cross-enterprise collaboration in radiology using the Austrian eHealth infrastructure". OBJECTIVES: The objective of this paper was to provide an overview of the radiology IT environment - actors, use cases and technology. METHODS: We conducted semi-structured expert interviews with radiologists and hospital operators and we statistically analyzed the client database of our research project partner...
2018: Studies in Health Technology and Informatics
Gary J Hodges, Matthew C Mueller, Stephen S Cheung, Bareket Falk
Few studies have investigated skin blood flow (SkBF) in children and age-related differences in the underlying mechanisms. We examined mechanisms of SkBF responses to local heating, post-occlusive reactive hyperaemia (PORH), and isometric hand-grip exercise (IHE) in adult and prepubescent males, hypothesizing that SkBF responses would be greater in children compared to adults. We measured SkBF in 12 boys (9±1 y) and 12 men (21±1 y) using laser-Doppler flowmetry at rest, in response to 3-min PORH, 2-min IHE, and local skin heating to 39°C (sub-maximal) and 44°C (maximal)...
April 24, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Bjoern Schreiweis, Tobias Bronsch, Angela Merzweiler, Bjoern Bergh
The re-use of healthcare information for biomedical research is increasing and with it the importance of a consent management framework implementing computable consents. Based on requirements concerning a consent representation the Advanced Patient Privacy Consents (APPC) Profile of Integrating the Healthcare Enterprise (IHE) is evaluated and mapped to these requirements. As IHE APPC was developed for computable patient consents, the mapping of consents for research projects is possible by re-using the elements defined...
2018: Studies in Health Technology and Informatics
Youngmin Kim, Prabhakar Ganesan, Junbeom Jo, Seong Ok Kim, Kamatchi Thamilselvan, Hyotcherl Ihee
Photoactive yellow protein (PYP) induces negative phototaxis in Halorhodospira halophila via photoactivation triggered by light-mediated chromophore isomerization. Chromophore isomerization proceeds via a volume-conserving isomerization mechanism due to hydrogen bond network and steric constraints inside the protein, and causes significant conformational changes accompanied by N-terminal protrusion. However, it is unclear how the structural change of chromophore affects the remote N-terminal domain. To understand photocycle-related structural changes, we investigated the structural aspect of chromophore removal in PYP because it possesses a disrupted hydrogen-bond network similar to that in photocycle intermediates...
April 12, 2018: Journal of Physical Chemistry. B
Adam P Sawatsky, Hannah C Nordhues, Stephen P Merry, M Usmaan Bashir, Frederic W Hafferty
PURPOSE: International health electives (IHEs) are widely available during residency and provide unique experiences for trainees. Theoretical models of professional identity formation and transformative learning may provide insight into residents' experiences during IHEs. The purpose of this study was to explore transformative learning and professional identity formation during resident IHEs and characterize the relationship between transformative learning and professional identity formation...
March 27, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
Sungkee Lee, Hyoungho Do
Objectives: Increasing use of medical devices outside of healthcare facilities inevitably requires connectivity and interoperability between medical devices and healthcare information systems. To this end, standards have been developed and used to provide interoperability between personal health devices (PHDs) and external systems. ISO/IEEE 11073 standards and IHE PCD-01 standard messages have been used the most in the exchange of observation data of health devices. Recently, transmitting observation data using the HL7 FHIR standard has been devised in the name of DoF (Devices on FHIR) and adopted very fast...
January 2018: Healthcare Informatics Research
Charles S Mayo, Jean M Moran, Walter Bosch, Ying Xiao, Todd McNutt, Richard Popple, Jeff Michalski, Mary Feng, Lawrence B Marks, Clifton D Fuller, Ellen Yorke, Jatinder Palta, Peter E Gabriel, Andrea Molineu, Martha M Matuszak, Elizabeth Covington, Kathryn Masi, Susan L Richardson, Timothy Ritter, Tomasz Morgas, Stella Flampouri, Lakshmi Santanam, Joseph A Moore, Thomas G Purdie, Robert C Miller, Coen Hurkmans, Judy Adams, Qing-Rong Jackie Wu, Colleen J Fox, Ramon Alfredo Siochi, Norman L Brown, Wilko Verbakel, Yves Archambault, Steven J Chmura, Andre L Dekker, Don G Eagle, Thomas J Fitzgerald, Theodore Hong, Rishabh Kapoor, Beth Lansing, Shruti Jolly, Mary E Napolitano, James Percy, Mark S Rose, Salim Siddiqui, Christof Schadt, William E Simon, William L Straube, Sara T St James, Kenneth Ulin, Sue S Yom, Torunn I Yock
A substantial barrier to the single- and multi-institutional aggregation of data to supporting clinical trials, practice quality improvement efforts, and development of big data analytics resource systems is the lack of standardized nomenclatures for expressing dosimetric data. To address this issue, the American Association of Physicists in Medicine (AAPM) Task Group 263 was charged with providing nomenclature guidelines and values in radiation oncology for use in clinical trials, data-pooling initiatives, population-based studies, and routine clinical care by standardizing: (1) structure names across image processing and treatment planning system platforms; (2) nomenclature for dosimetric data (eg, dose-volume histogram [DVH]-based metrics); (3) templates for clinical trial groups and users of an initial subset of software platforms to facilitate adoption of the standards; (4) formalism for nomenclature schema, which can accommodate the addition of other structures defined in the future...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
KyeoReh Lee, Youngmin Kim, JaeHwang Jung, Hyotcherl Ihee, YongKeun Park
A novel optical holographic technique is presented to simultaneously measure both the real and imaginary components of the complex refractive index (CRI) of a protein solution over a wide visible wavelength range. Quantitative phase imaging was employed to precisely measure the optical field transmitted from a protein solution, from which the CRIs of the protein solution were retrieved using the Fourier light scattering technique. Using this method, we characterized the CRIs of the two dominant structural states of a photoactive yellow protein solution over a broad wavelength range (461-582 nm)...
February 15, 2018: Scientific Reports
Carlos Luis Parra-Calderón, Jane Kaye, Alberto Moreno-Conde, Harriet Teare, Francisco Nuñez-Benjumea
Herein, we describe the characterization of a Digital Consent (DC) System to support current ethical-legal issues associated with challenges posed by informed consent for genomic research. A potential solution to support ongoing interaction with patients and allow control over how their data and samples are being used in genomic research can be Digital Consent based. But there are other challenges that need to be addressed, such as incidental findings when analyzing the results of genomic tests (not expected)...
April 2018: Journal of Community Genetics
Chi Woo Ahn, Hosung Ki, Joonghan Kim, Jeongho Kim, Sungjun Park, Yunbeom Lee, Kyung Hwan Kim, Qingyu Kong, Jiwon Moon, Martin Nors Pedersen, Michael Wulff, Hyotcherl Ihee
Photolysis of iodoform (CHI3 ) in solution has been extensively studied, but its reaction mechanism remains elusive. In particular, iso-iodoform (iso-CHI2 -I) is formed as a product of the photolysis reaction, but its detailed structure is not known, and whether it is a major intermediate species has been controversial. Here, by using time-resolved X-ray liquidography, we determined the reaction mechanism of CHI3 photodissociation in cyclohexane as well as the structure of iso-CHI2 -I. Both iso-CHI2 -I and CHI2 radical were found to be formed within 100 ps with a branching ratio of 40:60...
February 1, 2018: Journal of Physical Chemistry Letters
Sarah McMahon, Leila Wood, Julia Cusano, Lisa M Macri
Campus sexual assault (CSA) has received unprecedented attention over recent years, resulting in an abundance of federal guidance and mandates. In response, efforts to address and prevent CSA at Institutions of Higher Education (IHE) across the country have grown quickly, including the development and implementation of programs and policies. Because the changes on campuses have occurred at such a rapid pace, a number of gaps exist within the field of CSA research. To ensure that changes on IHE are evidence-based, there is a need to review the existing research available and the inquiry still needed, based on key areas outlined in federal guidance, the expressed needs of campus community members, survivors, and students who commit sexual offenses on college campuses...
January 1, 2018: Sexual Abuse: a Journal of Research and Treatment
Gabriele Bonanno, Allison G Hays, Robert G Weiss, Michael Schär
PURPOSE: Depressed coronary endothelial function (CEF) is a marker for atherosclerotic disease, an independent predictor of cardiovascular events, and can be quantified non-invasively with ECG-triggered spiral cine MRI combined with isometric handgrip exercise (IHE). However, MRI-CEF measures can be hindered by faulty ECG-triggering, leading to prolonged breath-holds and degraded image quality. Here, a self-gated golden angle spiral method (SG-GA) is proposed to eliminate the need for ECG during cine MRI...
December 27, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
T Jake Samuel, Rhys Beaudry, Mark J Haykowsky, Satyam Sarma, Suwon Park, Thomas Dombrowsky, Paul S Bhella, Michael D Nelson
BACKGROUND: Cycle exercise echocardiography is a useful tool to "unmask" diastolic dysfunction; however, this approach can be limited by respiratory and movement artifacts. Isometric handgrip avoids these issues while reproducibly increasing afterload and myocardial oxygen demand. HYPOTHESIS: Isometric handgrip echocardiography (IHE) can differentiate normal from abnormal diastolic function. METHODS: First recruited 19 young healthy individuals (mean age, 24 ± 4 years) to establish the "normal" response...
December 2017: Clinical Cardiology
Daniel Pinto Dos Santos, Gordon Arnhold, Peter Mildenberger, Christoph Düber, Roman Kloeckner
Purpose  To transfer the report sheet from the guidelines regarding the German Transplantation Act to a standards-compliant report template and to evaluate it in the clinical routine. Materials and Methods  The template was developed using the freely available software It was implemented in the clinical routine using a reporting platform developed in-house. Interfaces to the department RIS and PACS allowed for integration into the usual reporting workflow. The evaluation period was 70 days...
December 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Lena Mathews, Micaela Iantorno, Michael Schär, Gabriele Bonanno, Gary Gerstenblith, Robert G Weiss, Allison G Hays
BACKGROUND: Premenopausal women have fewer cardiovascular disease (CVD) events than postmenopausal women and age-matched men, but the reasons are not fully understood. Coronary endothelial function (CEF), a barometer of coronary vascular health, promises important insights into age and sex differences in atherosclerotic CVD risk, but has not been well characterized in healthy individuals because of the invasive nature of conventional CEF measurements. Recently developed magnetic resonance imaging (MRI) methods were used to quantify CEF (coronary area and flow changes in response to isometric handgrip exercise (IHE), an endothelial-dependent stressor) to test the hypothesis that healthy women have better CEF compared to men particularly at a younger age...
2017: PloS One
Amy Werremeyer, Elizabeth Skoy, Gina Aalgaard Kelly
Based on surveys and structured interviews, International Health Experiences (IHEs) improve cultural sensitivity, communication, and self-confidence among health professions students. However, open-ended methods to explore student learning during an IHE are not widely utilized. We sought to explore pharmacy student-identified learning during an IHE in an open-ended fashion using Photovoice methodology. Pharmacy students on an IHE in Guatemala were given disposable cameras and asked to photograph images that reflected their learning...
November 29, 2016: Pharmacy (Basel, Switzerland)
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