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https://www.readbyqxmd.com/read/29153631/human-abuse-potential-of-brivaracetam-in-healthy-recreational-central-nervous-system-depressant-users
#1
Kerri A Schoedel, Armel Stockis, Edward M Sellers
BACKGROUND: Brivaracetam is a new antiepileptic drug indicated for adjunctive treatment of focal seizures in adults at a dose of 50-200mg/day taken in two equal doses. The objective of this study was to evaluate the abuse potential of brivaracetam compared with alprazolam (positive control), placebo, and levetiracetam. METHODS: This was a randomized, double-blind, triple-dummy, crossover study in healthy male and female recreational central nervous system (CNS) depressant users aged 18-55years, who could distinguish between the subjective effects of alprazolam 2mg and placebo...
November 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29141839/patient-health-record-systems-scope-and-functionalities-literature-review-and-future-directions
#2
REVIEW
Lina Bouayad, Anna Ialynytchev, Balaji Padmanabhan
BACKGROUND: A new generation of user-centric information systems is emerging in health care as patient health record (PHR) systems. These systems create a platform supporting the new vision of health services that empowers patients and enables patient-provider communication, with the goal of improving health outcomes and reducing costs. This evolution has generated new sets of data and capabilities, providing opportunities and challenges at the user, system, and industry levels. OBJECTIVE: The objective of our study was to assess PHR data types and functionalities through a review of the literature to inform the health care informatics community, and to provide recommendations for PHR design, research, and practice...
November 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29140462/data-portal-for-the-library-of-integrated-network-based-cellular-signatures-lincs-program-integrated-access-to-diverse-large-scale-cellular-perturbation-response-data
#3
Amar Koleti, Raymond Terryn, Vasileios Stathias, Caty Chung, Daniel J Cooper, John P Turner, Dušica Vidovic, Michele Forlin, Tanya T Kelley, Alessandro D'Urso, Bryce K Allen, Denis Torre, Kathleen M Jagodnik, Lily Wang, Sherry L Jenkins, Christopher Mader, Wen Niu, Mehdi Fazel, Naim Mahi, Marcin Pilarczyk, Nicholas Clark, Behrouz Shamsaei, Jarek Meller, Juozas Vasiliauskas, John Reichard, Mario Medvedovic, Avi Ma'ayan, Ajay Pillai, Stephan C Schürer
The Library of Integrated Network-based Cellular Signatures (LINCS) program is a national consortium funded by the NIH to generate a diverse and extensive reference library of cell-based perturbation-response signatures, along with novel data analytics tools to improve our understanding of human diseases at the systems level. In contrast to other large-scale data generation efforts, LINCS Data and Signature Generation Centers (DSGCs) employ a wide range of assay technologies cataloging diverse cellular responses...
November 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29138130/check-and-report-ebola-care-hotline-the-user-perspective-of-an-innovative-tool-for-postarrival-monitoring-of-ebola-in-the-united-states
#4
Ilana Olin McCarthy, Abbey E Wojno, Heather A Joseph, Scott Teesdale
BACKGROUND: The response to the 2014-2016 Ebola epidemic included an unprecedented effort from federal, state, and local public health authorities to monitor the health of travelers entering the United States from countries with Ebola outbreaks. The Check and Report Ebola (CARE) Hotline, a novel approach to monitoring, was designed to enable travelers to report their health status daily to an interactive voice recognition (IVR) system. The system was tested with 70 Centers for Disease Control and Prevention (CDC) federal employees returning from deployments in outbreak countries...
November 14, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29137639/proactive-ethical-design-for-neuroengineering-assistive-and-rehabilitation-technologies-the-cybathlon-lesson
#5
REVIEW
Marcello Ienca, Reto W Kressig, Fabrice Jotterand, Bernice Elger
BACKGROUND: Rapid advancements in rehabilitation science and the widespread application of engineering techniques are opening the prospect of a new phase of clinical and commercial maturity for Neuroengineering, Assistive and Rehabilitation Technologies (NARTs). As the field enters this new phase, there is an urgent need to address and anticipate the ethical implications associated with novel technological opportunities, clinical solutions, and social applications. MAIN IDEA: In this paper we review possible approaches to the ethics of NART, and propose a framework for ethical design and development, which we call the Proactive Ethical Design (PED) framework...
November 14, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29135752/experiences-and-shared-meaning-of-teamwork-and-interprofessional-collaboration-among-health-care-professionals-in-primary-health-care-settings-a-systematic-review
#6
Carine Sangaleti, Mariana Cabral Schveitzer, Marina Peduzzi, Elma Lourdes Campos Pavone Zoboli, Cassia Baldini Soares
BACKGROUND: During the last decade, teamwork has been addressed under the rationale of interprofessional practice or collaboration, highlighted by the attributes of this practice such as: interdependence of professional actions, focus on user needs, negotiation between professionals, shared decision making, mutual respect and trust among professionals, and acknowledgment of the role and work of the different professional groups. Teamwork and interprofessional collaboration have been pointed out as astrategy for effective organization of health care services as the complexity of healthcare requires integration of knowledge and practices from differente professional groups...
November 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29132622/know-thy-ehealth-user-development-of-biopsychosocial-personas-from-a-study-of-older-adults-with-heart-failure
#7
Richard J Holden, Anand Kulanthaivel, Saptarshi Purkayastha, Kathryn M Goggins, Sunil Kripalani
BACKGROUND: Personas are a canonical user-centered design method increasingly used in health informatics research. Personas-empirically-derived user archetypes-can be used by eHealth designers to gain a robust understanding of their target end users such as patients. OBJECTIVE: To develop biopsychosocial personas of older patients with heart failure using quantitative analysis of survey data. METHOD: Data were collected using standardized surveys and medical record abstraction from 32 older adults with heart failure recently hospitalized for acute heart failure exacerbation...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29123354/profile-of-patients-opting-for-palliative-care-in-india
#8
Prince John, Ravindra B Ghooi
Introduction: Understanding the profile of end users is a key input for designing a service. Centers that provide full-scale palliative care are few and far between in our country, and there is a need to open more centers to extend the services to a larger percentage of patients. Methods: Patient data from the inception of the center till January 2016 have been stored in a database. The data were mined, exported to Excel, and analyzed. Results: The data of 11,258 patients revealed the profile of patients, including their age, gender distribution, marital status, symptomology, and outcome...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29106311/impact-of-an-automated-bihormonal-delivery-system-on-psychosocial-outcomes-in-adults-with-type-1-diabetes
#9
Jill Weissberg-Benchell, Danielle Hessler, Lawrence Fisher, Steven J Russell, William H Polonsky
OBJECTIVES: The study assessed the psychosocial impact of the bihormonal bionic pancreas (BP) on adults in a real-world outpatient setting. RESEARCH DESIGN AND METHODS: Thirty-nine adults with type 1 diabetes at four study centers across the U.S. participated in a two-arm, random-order, crossover design study: 11 days with the BP and 11 days with their usual care (UC). Psychosocial questionnaires were administered before the first study arm, at the end of the first study arm, and at the end of the second study arm...
November 6, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29104719/discovering-black-soap-a-survey-on-the-attitudes-and-practices-of-black-soap-users
#10
Ann Lin, Adam Nabatian, Caroline P Halverstam
OBJECTIVE: The purpose of this study was to discover the general attitudes and practices of black soap users with regard to amelioration of various dermatologic conditions. DESIGN: This was a prospective questionnaire-based study with a sample size of 100 black soap users. Setting: Outpatient dermatology clinics of Montefiore Medical Center and other Albert Einstein affiliated dermatology clinics in Bronx, New York. PARTICIPANTS: One hundred subjects who have used black soap were recruited. MEASUREMENTS: The participants evaluated and reported their attitudes and applications of black soap...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29104674/the-bus-framework-a-comprehensive-tool-in-creating-an-mhealth-app-utilizing-behavior-change-theories-user-centered-design-and-social-marketing
#11
Sajani Patel, Monisha Arya
No abstract text is available yet for this article.
April 2017: Journal of Mobile Technology in Medicine
https://www.readbyqxmd.com/read/29096710/putting-research-in-place-an-innovative-approach-to-providing-contextualized-evidence-synthesis-for-decision-makers
#12
Stephen Bornstein, Rochelle Baker, Pablo Navarro, Sarah Mackey, David Speed, Melissa Sullivan
BACKGROUND: The Contextualized Health Research Synthesis Program (CHRSP), developed in 2007 by the Newfoundland and Labrador Centre for Applied Health Research, produces contextualized knowledge syntheses for health-system decision makers. The program provides timely, relevant, and easy-to-understand scientific evidence; optimizes evidence uptake; and, most importantly, attunes research questions and evidence to the specific context in which knowledge users must apply the findings. METHODS: As an integrated knowledge translation (KT) method, CHRSP: Involves intensive partnerships with senior healthcare decision makers who propose priority research topics and participate on research teams; Considers local context both in framing the research question and in reporting the findings; Makes economical use of resources by utilizing a limited number of staff; Uses a combination of external and local experts; and Works quickly by synthesizing high-level systematic review evidence rather than primary studies...
November 2, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29093966/rethink-space-re-designing-a-workspace-using-human-centered-design-to-support-flexibility-collaboration-and-engagement-among-clinical-and-translational-research-support-services
#13
Aalap Doshi, Christina Clay
Introduction: Space matters. We read space like we read people's faces. Space is an instrument of collaboration and innovation. At the University of Michigan's Institute for Clinical and Health Research (MICHR), a team was created to creatively and economically enhance our operating space into a flexible workspace that supports privacy, innovation, creativity, and most important, a culture of collaboration. Methods: The team used a human-centered design process to creatively engage the staff at large into analyzing our existing space, identifying latent needs, proposing solutions, generating feedback, and economically building the rethought process...
June 2017: Journal of clinical and translational science
https://www.readbyqxmd.com/read/29092473/stand-alone-polarization-modulation-infrared-reflection-absorption-spectroscopy-instrument-optimized-for-the-study-of-catalytic-processes-at-elevated-pressures
#14
John D Kestell, Kumudu Mudiyanselage, Xinyi Ye, Chang-Yong Nam, Dario Stacchiola, Jerzy Sadowski, J Anibal Boscoboinik
This paper describes the design and construction of a compact, "user-friendly" polarization-modulation infrared reflection absorption spectroscopy (PM-IRRAS) instrument at the Center for Functional Nanomaterials (CFN) of Brookhaven National Laboratory, which allows studying surfaces at pressures ranging from ultra-high vacuum to 100 Torr. Surface infrared spectroscopy is ideally suited for studying these processes as the vibrational frequencies of the IR chromophores are sensitive to the nature of the bonding environment on the surface...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29091996/visualization-portal-for-genetic-variation-vizgvar-a-tool-for-interactive-visualization-of-snps-and-somatic-mutations-in-exons-genes-and-protein-domains
#15
Antonio Solano Román, Verónica Alfaro, Carlos Cruz, Allan Orozco Solano
Motivation: VizGVar was designed to meet the growing need of the research community for improved genomic and proteomic data viewers that benefit from better information visualization. Results: We implemented a new information architecture and applied user centered design principles to provide a new improved way of visualizing genetic information and protein data related to human disease. VizGVar connects the entire database of Ensembl protein motifs, domains, genes and exons with annotated SNPs and somatic variations from PharmGKB and COSMIC...
October 30, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29079555/-thanks-for-letting-us-all-share-your-mammogram-experience-virtually-developing-a-web-based-hub-for-breast-cancer-screening
#16
Adam Galpin, Joanne Meredith, Cathy Ure, Leslie Robinson
BACKGROUND: The decision around whether to attend breast cancer screening can often involve making sense of confusing and contradictory information on its risks and benefits. The Word of Mouth Mammogram e-Network (WoMMeN) project was established to create a Web-based resource to support decision making regarding breast cancer screening. This paper presents data from our user-centered approach in engaging stakeholders (both health professionals and service users) in the design of this Web-based resource...
October 27, 2017: JMIR Cancer
https://www.readbyqxmd.com/read/29066421/caregiver-input-to-optimize-the-design-of-a-pediatric-care-planning-guide-for-rehabilitation-descriptive-study
#17
Mary A Khetani, Heather K Lim, Marya E Corden
BACKGROUND: Caregiver input has informed the design of a valid electronic patient-reported outcome (PRO) measure for use in pediatric rehabilitation. This proxy assessment may be further developed to expedite and enhance patient-centered care planning processes, but user input is first needed to finalize the core requirements that will guide its design. OBJECTIVE: The objective of this study was to examine the feasibility of a stepwise process for building on a baseline assessment of young children's participation in activities to develop a care plan relevant to pediatric rehabilitation...
October 24, 2017: JMIR Rehabil Assist Technol
https://www.readbyqxmd.com/read/29063544/best-paper-selection
#18
(no author information available yet)
Castro GM, Buczkowski L, Hafner JM. The Contribution of Sociotechnical Factors to Health Information Technology-Related Sentinel Events. Jt Comm J Qual Patient Saf 2016 Feb;42(2):70-6 https://linkinghub.elsevier.com/retrieve/pii/S1553-7250(16)42008-8 Horsky J, Ramelson HZ. Development of a cognitive framework of patient record summary review in the formative phase of user-centered design. J Biomed Inform 2016 Dec;64:147-57 http://www.sciencedirect.com/science/article/pii/S153204641630137X?via%3Dihub Kobayashi L, Gosbee JW, Merck DL...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29062533/the-consultation-of-rugby-players-in-co-developing-a-player-health-study-feasibility-and-consequences-of-sports-participants-as-research-partners
#19
Madeleine A M Davies, Edward Balai, Jo Adams, John-Henry Carter, Andrew Judge, Julia L Newton, Nigel K Arden
PLAIN ENGLISH SUMMARY: Many funding bodies within the United Kingdom and globally have encouraged public involvement in research. The Department of Health has also called public involvement a sign of good research. Despite the wide acceptance of public involvement improving many aspects of research, from its design to its communication, involvement has varied levels of implementation across different fields of research. Sports people have rarely been involved in research, partly as this research tends not to be funded by mainstream funding bodies...
2017: Res Involv Engagem
https://www.readbyqxmd.com/read/29061553/veterans-preferences-for-exchanging-information-using-veterans-affairs-health-information-technologies-focus-group-results-and-modeling-simulations
#20
Jolie N Haun, Margeaux Chavez, Kim Nazi, Nicole Antinori, Christine Melillo, Bridget A Cotner, Wendy Hathaway, Ashley Cook, Nancy Wilck, Abigail Noonan
BACKGROUND: The Department of Veterans Affairs (VA) has multiple health information technology (HIT) resources for veterans to support their health care management. These include a patient portal, VetLink Kiosks, mobile apps, and telehealth services. The veteran patient population has a variety of needs and preferences that can inform current VA HIT redesign efforts to meet consumer needs. OBJECTIVE: This study aimed to describe veterans' experiences using the current VA HIT and identify their vision for the future of an integrated VA HIT system...
October 23, 2017: Journal of Medical Internet Research
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