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congenital giant nevus

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https://www.readbyqxmd.com/read/27857802/giant-melanocytic-nevi-with-neurocutaneous-melanosis-masquerading-as-neurofibromas
#1
Vykuntaraju K Gowda, Anita Basude, Sahana M Srinivas, Maya Bhat
Neurocutaneous melanosis is congenital melanocytic nevus with neurological manifestations. We report a 4-year-old female child presenting with hyperpigmented and nodular skin lesion associated with developmental delay and convulsions. The child had multiple brownish-black nevi on the face and chest and giant melanocytic nevi on thoraco-abdomen, back, and gluteal region. Computed tomography scan of the brain showed calcification in the pons, right cerebellar hemisphere, and left medial temporal lobe. Skin biopsy done from nodular hyperpigmented site was suggestive of melanocytic nevi...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27720389/expanded-bi-pedicled-sleeve-flap-for-reconstruction-of-the-upper-extremity-after-large-circumferential-nevus-excision-in-children
#2
Yair Shachar, Allan Billig, Katya Chapchay, Jhonatan Elia, Neta Adler, Alexander Margulis
BACKGROUND: Large congenital melanocytic nevi entail significant medical and cosmetic ramifications for patients and families. Reconstruction is a challenging endeavor, especially when the lesion is present on the limbs. The literature describes various methods by which a plastic surgeon can address reconstruction; yet, to date, there has been no series describing a method that provides consistent results with low complication rates. In this study, we describe our surgical technique for reconstruction of the upper extremity after excision of large circumferential CNM with a pre-expanded bi-pedicled flap, namely the "sleeve" flap...
October 5, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27579751/melanoma-associated-with-congenital-intermediate-common-blue-nevus-of-the-scalp-case-report
#3
Camila Sampaio Ribeiro, Sergio S Serpa, Maria Auxiliadora Jeunon Sousa, Thiago Jeunon
Melanomas can arise either de novo (70%) or from pre-existing melanocytic lesions (30%). Of the latter, most cases arise at the dermoepidermal junction from small congenital or acquired non-blue nevi while only a few arise from blue nevi, notably the cellular subtype and less commonly the common (dendritic) type. Melanomas that arise from blue nevi usually occur on the scalp with greater frequency, as in the case described. Although previous studies have discussed melanoma arising from giant congenital blue nevi, few have discussed those arising from intermediate blue nevi...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27573553/prepubertal-melanoma-arising-within-a-medium-sized-congenital-melanocytic-nevus
#4
Leah Lalor, Klaus Busam, Kara Shah
We report the case of an 8-year-old child who developed a 9.4-mm-deep melanoma within a medium-sized congenital melanocytic nevus on the scalp. Genetic analysis revealed an activating NRAS Q61R mutation within the melanoma, which is more commonly associated with large or giant congenital melanocytic nevi. This case demonstrates that even a "low-risk" congenital melanocytic nevus at a "low-risk" age must be monitored regularly for the development of malignancy.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27515295/an-exploratory-clinical-trial-of-a-novel-treatment-for-giant-congenital-melanocytic-nevi-combining-inactivated-autologous-nevus-tissue-by-high-hydrostatic-pressure-and-a-cultured-epidermal-autograft-study-protocol
#5
Naoki Morimoto, Chizuru Jinno, Michiharu Sakamoto, Natsuko Kakudo, Tetsuji Yamaoka, Kenji Kusumoto
BACKGROUND: Giant congenital melanocytic nevi (GCMNs) are large brown to black skin lesions that appear at birth and are associated with a risk of malignant transformation. It is often difficult to reconstruct large full-thickness skin defects after the removal of GCMNs. OBJECTIVE: To overcome this difficulty we developed a novel treatment to inactivate nevus tissue and reconstruct the skin defect using the nevus tissue itself. For this research, we designed an exploratory clinical study to investigate the safety and efficacy of a novel treatment combining the engraftment of autologous nevus tissue inactivated by high hydrostatic pressurization with a cultured epidermal autograft (CEA)...
2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27423683/age-related-changes-in-brain-mr-appearance-in-the-course-of-neurocutaneous-melanosis
#6
Monika Bekiesińska-Figatowska, Ewa Sawicka, Klaudia Żak, Orest Szczygielski
BACKGROUND: Patients with giant congenital melanocytic nevi (GCMN) have increased risk of neurocutaneous melanosis (NCM). Brain MRI is mandatory in GCMN. OBJECTIVES: To present the age related changes in brain MRI in children with NCM during several-year follow-up. METHODS: In 7 NCM children following data were analyzed: main nevus localization, surgical treatment phase, histology of excised nevi, time of NCM diagnosis, number of MRI studies, neurological symptoms, changes of melanin deposits in brain during follow-up...
August 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27373137/giant-congenital-melanocytic-nevus-in-a-bulgarian-newborn
#7
A A Chokoeva, M Fioranelli, M G Roccia, T Lotti, U Wollina, G Tchernev
Giant congenital melanocytic nevus (GCMN) is a rare disorder affecting 1 in 200,000–500,000 live births. Central nervous system defects such as spina bifida, meningocele, Dandy Walker malformation may accompany it and thus cause significant morbidity. Despite the related risk for malignant transformation, GCMNs may be associated with neurocutaneous melanosis, a rare syndrome in which a giant CMN or multiple smaller CMNs are accompanied by melanocytic deposition in the brain and the spinal cord. We present a case of a 5-day-old newborn with giant congenital melanocytic nevus on his back, as we discuss the diagnostic and treatment approach...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27227469/recurrent-nevi-in-a-skin-graft-following-excision-of-giant-congenital-melanocytic-nevus
#8
Maressa C Criscito, Lilia M Correa, Vadim P Koshenkov, Bahar F Firoz
No abstract text is available yet for this article.
September 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27057033/giant-congenital-melanocytic-nevus-with-occipital-encephalocele-a-very-rare-association
#9
Surajit Gorai, Mahimanjan Saha, Joly Seth
No abstract text is available yet for this article.
March 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27051741/innumerable-nevi-with-giant-congenital-melanocytic-nevus-clinically-mimicking-neurofibromatosis-a-diagnostic-challenge
#10
Lindsay N Boyers, Chante Karimkhani, Emily Stevens, Whitney A High
No abstract text is available yet for this article.
September 2015: JAAD Case Reports
https://www.readbyqxmd.com/read/27014556/giant-congenital-sclerosing-blue-nevus-of-the-scalp-presenting-with-rapidly-disseminated-fatal-metastases-in-a-pediatric-patient
#11
Michael V DeFazio, Jerry W Chao, Albert K Oh, Gary F Rogers
No abstract text is available yet for this article.
February 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27002537/verification-of-the-inactivation-of-melanocytic-nevus-in-vitro-using-a-newly-developed-portable-high-hydrostatic-pressure-device
#12
Naoki Morimoto, Chizuru Jinno, Atsushi Mahara, Natsuko Kakudo, Toshia Fujisato, Kenji Kusumoto, Shigehiko Suzuki, Tetsuji Yamaoka
High hydrostatic pressure (HHP) technology is a physical method for inactivating tissue. We reported that nevus specimens were inactivated after HHP at 200 MPa and that the inactivated nevus could be used as autologous dermis for covering skin defects. In this study, we verified the inactivation of nevus specimens using a newly developed portable HHP device which will be used in a clinical trial. Nevus tissue specimens were obtained from 5 patients (mean age 7.2 years, range 1-19). We cultured fibroblasts and nevus cells from the tissue specimens and then evaluated their inactivation after HHP at 200 MPa by confirming the attachment of the suspensions and by the live/dead staining of the suspensions, through the dissociation of the cells on chamber slides and by the live/dead staining of the remaining cells...
2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/26973729/sonographic-and-magnetic-resonance-imaging-findings-of-neurocutaneous-melanosis
#13
Yingming Amy Chen, Joel Woodley-Cook, Michael Sgro, Aditya Bharatha
Neurocutaneous melanosis is a rare nonfamilial phakomatosis characterized by large or multiple congenital melanocytic nevi plus the presence of central nervous system melanosis or melanoma. We report a case of a male infant with a giant posteroaxial nevus and evidence of intracranial melanosis on ultrasound and magnetic resonance imaging.
March 2016: Radiology case reports
https://www.readbyqxmd.com/read/26955158/giant-cerebriform-congenital-cellular-blue-nevus-presenting-as-cutis-verticis-gyrata
#14
Angoori Gnaneshwar Rao, Divya Koppada, M Haritha
No abstract text is available yet for this article.
January 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/26538733/bilateral-symmetrical-congenital-giant-becker-s-nevus-a-rare-presentation
#15
Angoori Gnaneshwar Rao
Becker's nevus is a focal epidermal hypermelanotic disorder. It morphologically presents as unilateral, hyperpigmented, hypertrichotic patch on upper trunk, proximal upper extremities and arms. However, Becker's nevus presenting as bilateral, symmetrical patches is rare. Herein, we report a rare case of giant Becker's nevus with bilateral symmetrical presentation in an adult male.
September 2015: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/26379904/neurofibroma-and-lipoma-in-association-with-giant-congenital-melanocytic-nevus-coexisting-in-one-nodule-a-case-report
#16
Zhiwei Shang, Tao Dai, Yongqiang Ren
Giant congenital melanocytic nevi (GCMN) are rare conditions that defined as melanocytic lesion recognized at birth, which will reach a diameter larger than 20 cm, and they occur in about 1 per 500,000 newborns. Despite its rarity, they may associate with severe abnormalities like spina bifida occulta, meningocele, club foot and hypertrophy or atrophy of deeper structures of a limb, Carney complex, premature aging syndromes, neurofibroma, vitiligo, lipoma and dysplasia of bilateral hip impact on the patient...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26301158/extraordinary-large-giant-congenital-melanocytic-nevus-treated-with-integra-dermal-regeneration-template
#17
Kim A Tønseth, Charles Filip, Robert Hermann, Harald Vindenes, Hans Erik Høgevold
Garment-like giant congenital melanocytic nevi are very rare, and those being treated are most often offered excision and split-thickness skin transplantation. Due to the risk of restricted mobility secondary to shrinkage and hypertrophic scarring of the transplant, we treated to date the largest reported giant congenital melanocytic nevus (16% total body surface area) with Integra dermal regeneration template (Integra Life Sciences, Plainsboro, N.J.), giving a more functional skin reconstruction. In addition, the dermal regeneration template had to be covered with split-thickness skin transplant including multiple smaller nevi due to lack of larger area with normal skin...
July 2015: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/26268779/benign-melanocytic-lymph-node-deposits-in-the-setting-of-giant-congenital-melanocytic-nevi-the-large-congenital-nodal-nevus
#18
Anneli R Bowen, Keith L Duffy, Frederic C Clayton, Robert H I Andtbacka, Scott R Florell
BACKGROUND: Benign melanocytic rests are a frequent finding in superficial lymph nodes removed during sentinel lymph node biopsies for melanoma. Whereas the histopathology of these deposits is well understood, very little is known regarding melanocytic lymph node deposits in the setting of giant congenital melanocytic nevi. METHODS: We analyzed lymph nodes removed from the drainage basin of giant congenital melanocytic nevi in three patients who had developed melanoma within their giant congenital nevi...
November 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/26266759/amplification-of-mutated-nras-leading-to-congenital-melanoma-in-neurocutaneous-melanocytosis
#19
Cláudia M Salgado, Dipanjan Basu, Marina Nikiforova, Ronald L Hamilton, Robin Gehris, Regina Jakacki, Ashok Panigrahy, Svetlana Yatsenko, Miguel Reyes-Múgica
The mechanisms behind malignant progression in patients with giant nevi are largely unknown. Here, we aim to describe novel genetic findings and explain possible mechanisms resulting in the most severe form of neurocutaneous melanocytosis. Detailed histological (biopsy and post-mortem) studies, tissue culture, and high-resolution cytogenetic analysis, including chromosome and array comparative genomic hybridization, Ion AmpliSeq Cancer Panel, and Sanger sequencing, were performed on tissues from a white male who succumbed at 17 months of age to congenital melanoma associated with a bathing-trunk nevus...
October 2015: Melanoma Research
https://www.readbyqxmd.com/read/26171106/giant-congenital-melanocytic-nevus-of-the-buttock
#20
Andrew A Marano, Adam M Feintisch, Ramazi Datiashvili
No abstract text is available yet for this article.
2015: Eplasty
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