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congenital giant nevus

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https://www.readbyqxmd.com/read/28419495/giant-proliferating-trichilemmal-cyst-arising-from-a-nevus-sebaceus-growing-for-thirty-years
#1
Scott F Lindsey, Divya Aickara, Alexandra Price, Janelle Pavlis, Erin X Wei, George Elgart, Jeong Hee Cho-Vega
Nevus sebaceus of Jadassohn, a congenital cutaneous hamartoma, has the potential to develop into various epidermal adnexal-origin neoplasms. While the most common neoplasms are trichoblastoma or syringocystadenoma, proliferating trichilemmal cysts are exceptionally rare. We report a case of a 63-year-old Cuban male with a giant proliferating trichilemmal cyst arising from a nevus sebaceus on the right shoulder which had been growing for 30 years. Proliferating trichilemmal cysts arising from nevus sebaceus cases are difficult to diagnose clinically and histologically since they are very rare and have not been defined by exact diagnostic criteria...
April 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28329507/giant-benign-intradermal-melanocytic-nevus-of-rapid-onset
#2
Sarah J Coates, Andrew Avarbock, Garrett T Desman
Benign melanocytic nevi are slowly growing acquiredor congenital tumors with varied morphology,commonly encountered in dermatology clinics. Anytumor with rapid clinical growth must be assessedcarefully in order to exclude malignancy. We report awoman with a histopathologically benign intradermalnevus that presented as a rapidly evolving largecutaneous mass on the ear. Owing to the discrepancybetween the clinical and histopathological findings,an extensive histopathological work-up involvingmany deeper sections, immunohistochemical stains,and fluorescent in situ hybridization (FISH) analysiswas conducted in order to rule out malignancy...
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28254210/giant-congenital-melanocytic-nevus-presenting-as-a-huge-vulvar-mass-a-rare-case
#3
Manu Goyal, Alka Kriplani, Reeta Mahey, Garima Kachhawa, Rajni Yadav, Geetika Singh
No abstract text is available yet for this article.
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28239913/-sky-full-of-stars-pattern-dermoscopic-findings-in-a-desmoplastic-giant-congenital-melanocytic-nevus
#4
Pablo Martín-Carrasco, José Bernabeu-Wittel, Javier Dominguez-Cruz, Teresa Zulueta Dorado, Julian Conejo-Mir Sanchez
Desmoplastic giant congenital melanocytic nevus (DGCN) is an uncommon variant of congenital nevus, presenting as a progressive induration and hypopigmentation of the lesion that occasionally causes hair loss and even total or partial disappearance of the nevus. A 6-month-old girl with a giant congenital melanocytic nevus that involved the entire posterior side of the right thigh was seen in our department. Nine months later, the peripheral area of the nevus presented as a marked induration with hypopigmentation...
February 27, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28110826/congenital-melanocytic-nevus-syndrome-a-case-series
#5
A Recio, A I Sánchez-Moya, V Félix, Y Campos
Congenital melanocytic nevus syndrome (CMNS) is the result of an abnormal proliferation of melanocytes in the skin and central nervous system caused by progenitor-cell mutations during embryonic development. Mutations in the NRAS gene have been detected in many of these cells. We present 5 cases of giant congenital melanocytic nevus, 3 of them associated with CMNS; NRAS gene mutation was studied in these 3 patients. Until a few years ago, surgery was the treatment of choice, but the results have proved unsatisfactory because aggressive interventions do not improve cosmetic appearance and only minimally reduce the risk of malignant change...
January 19, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28033154/malignant-melanoma-in-association-with-a-thymic-nevus-in-a-patient-with-a-giant-congenital-nevus
#6
Yulia Shvartser-Beryozkin, Alexander Yakobson, Daniel Benharroch, Milton Saute, Meora Feinmesser
Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27857802/giant-melanocytic-nevi-with-neurocutaneous-melanosis-masquerading-as-neurofibromas
#7
Vykuntaraju K Gowda, Anita Basude, Sahana M Srinivas, Maya Bhat
Neurocutaneous melanosis is congenital melanocytic nevus with neurological manifestations. We report a 4-year-old female child presenting with hyperpigmented and nodular skin lesion associated with developmental delay and convulsions. The child had multiple brownish-black nevi on the face and chest and giant melanocytic nevi on thoraco-abdomen, back, and gluteal region. Computed tomography scan of the brain showed calcification in the pons, right cerebellar hemisphere, and left medial temporal lobe. Skin biopsy done from nodular hyperpigmented site was suggestive of melanocytic nevi...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27720389/expanded-bi-pedicled-sleeve-flap-for-reconstruction-of-the-upper-extremity-after-large-circumferential-nevus-excision-in-children
#8
Yair Shachar, Allan Billig, Katya Chapchay, Jhonatan Elia, Neta Adler, Alexander Margulis
BACKGROUND: Large congenital melanocytic nevi entail significant medical and cosmetic ramifications for patients and families. Reconstruction is a challenging endeavor, especially when the lesion is present on the limbs. The literature describes various methods by which a plastic surgeon can address reconstruction; yet, to date, there has been no series describing a method that provides consistent results with low complication rates. In this study, we describe our surgical technique for reconstruction of the upper extremity after excision of large circumferential CNM with a pre-expanded bi-pedicled flap, namely the "sleeve" flap...
December 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27579751/melanoma-associated-with-congenital-intermediate-common-blue-nevus-of-the-scalp-case-report
#9
Camila Sampaio Ribeiro, Sergio S Serpa, Maria Auxiliadora Jeunon Sousa, Thiago Jeunon
Melanomas can arise either de novo (70%) or from pre-existing melanocytic lesions (30%). Of the latter, most cases arise at the dermoepidermal junction from small congenital or acquired non-blue nevi while only a few arise from blue nevi, notably the cellular subtype and less commonly the common (dendritic) type. Melanomas that arise from blue nevi usually occur on the scalp with greater frequency, as in the case described. Although previous studies have discussed melanoma arising from giant congenital blue nevi, few have discussed those arising from intermediate blue nevi...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27573553/prepubertal-melanoma-arising-within-a-medium-sized-congenital-melanocytic-nevus
#10
Leah Lalor, Klaus Busam, Kara Shah
We report the case of an 8-year-old child who developed a 9.4-mm-deep melanoma within a medium-sized congenital melanocytic nevus on the scalp. Genetic analysis revealed an activating NRAS Q61R mutation within the melanoma, which is more commonly associated with large or giant congenital melanocytic nevi. This case demonstrates that even a "low-risk" congenital melanocytic nevus at a "low-risk" age must be monitored regularly for the development of malignancy.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27515295/an-exploratory-clinical-trial-of-a-novel-treatment-for-giant-congenital-melanocytic-nevi-combining-inactivated-autologous-nevus-tissue-by-high-hydrostatic-pressure-and-a-cultured-epidermal-autograft-study-protocol
#11
Naoki Morimoto, Chizuru Jinno, Michiharu Sakamoto, Natsuko Kakudo, Tetsuji Yamaoka, Kenji Kusumoto
BACKGROUND: Giant congenital melanocytic nevi (GCMNs) are large brown to black skin lesions that appear at birth and are associated with a risk of malignant transformation. It is often difficult to reconstruct large full-thickness skin defects after the removal of GCMNs. OBJECTIVE: To overcome this difficulty we developed a novel treatment to inactivate nevus tissue and reconstruct the skin defect using the nevus tissue itself. For this research, we designed an exploratory clinical study to investigate the safety and efficacy of a novel treatment combining the engraftment of autologous nevus tissue inactivated by high hydrostatic pressurization with a cultured epidermal autograft (CEA)...
August 11, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27423683/age-related-changes-in-brain-mr-appearance-in-the-course-of-neurocutaneous-melanosis
#12
Monika Bekiesińska-Figatowska, Ewa Sawicka, Klaudia Żak, Orest Szczygielski
BACKGROUND: Patients with giant congenital melanocytic nevi (GCMN) have increased risk of neurocutaneous melanosis (NCM). Brain MRI is mandatory in GCMN. OBJECTIVES: To present the age related changes in brain MRI in children with NCM during several-year follow-up. METHODS: In 7 NCM children following data were analyzed: main nevus localization, surgical treatment phase, histology of excised nevi, time of NCM diagnosis, number of MRI studies, neurological symptoms, changes of melanin deposits in brain during follow-up...
August 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27373137/giant-congenital-melanocytic-nevus-in-a-bulgarian-newborn
#13
A A Chokoeva, M Fioranelli, M G Roccia, T Lotti, U Wollina, G Tchernev
Giant congenital melanocytic nevus (GCMN) is a rare disorder affecting 1 in 200,000–500,000 live births. Central nervous system defects such as spina bifida, meningocele, Dandy Walker malformation may accompany it and thus cause significant morbidity. Despite the related risk for malignant transformation, GCMNs may be associated with neurocutaneous melanosis, a rare syndrome in which a giant CMN or multiple smaller CMNs are accompanied by melanocytic deposition in the brain and the spinal cord. We present a case of a 5-day-old newborn with giant congenital melanocytic nevus on his back, as we discuss the diagnostic and treatment approach...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27227469/recurrent-nevi-in-a-skin-graft-following-excision-of-giant-congenital-melanocytic-nevus
#14
Maressa C Criscito, Lilia M Correa, Vadim P Koshenkov, Bahar F Firoz
No abstract text is available yet for this article.
September 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27057033/giant-congenital-melanocytic-nevus-with-occipital-encephalocele-a-very-rare-association
#15
Surajit Gorai, Mahimanjan Saha, Joly Seth
No abstract text is available yet for this article.
March 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27051741/innumerable-nevi-with-giant-congenital-melanocytic-nevus-clinically-mimicking-neurofibromatosis-a-diagnostic-challenge
#16
Lindsay N Boyers, Chante Karimkhani, Emily Stevens, Whitney A High
No abstract text is available yet for this article.
September 2015: JAAD Case Reports
https://www.readbyqxmd.com/read/27014556/giant-congenital-sclerosing-blue-nevus-of-the-scalp-presenting-with-rapidly-disseminated-fatal-metastases-in-a-pediatric-patient
#17
Michael V DeFazio, Jerry W Chao, Albert K Oh, Gary F Rogers
No abstract text is available yet for this article.
February 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27002537/verification-of-the-inactivation-of-melanocytic-nevus-in-vitro-using-a-newly-developed-portable-high-hydrostatic-pressure-device
#18
Naoki Morimoto, Chizuru Jinno, Atsushi Mahara, Natsuko Kakudo, Toshia Fujisato, Kenji Kusumoto, Shigehiko Suzuki, Tetsuji Yamaoka
High hydrostatic pressure (HHP) technology is a physical method for inactivating tissue. We reported that nevus specimens were inactivated after HHP at 200 MPa and that the inactivated nevus could be used as autologous dermis for covering skin defects. In this study, we verified the inactivation of nevus specimens using a newly developed portable HHP device which will be used in a clinical trial. Nevus tissue specimens were obtained from 5 patients (mean age 7.2 years, range 1-19). We cultured fibroblasts and nevus cells from the tissue specimens and then evaluated their inactivation after HHP at 200 MPa by confirming the attachment of the suspensions and by the live/dead staining of the suspensions, through the dissociation of the cells on chamber slides and by the live/dead staining of the remaining cells...
2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/26973729/sonographic-and-magnetic-resonance-imaging-findings-of-neurocutaneous-melanosis
#19
Yingming Amy Chen, Joel Woodley-Cook, Michael Sgro, Aditya Bharatha
Neurocutaneous melanosis is a rare nonfamilial phakomatosis characterized by large or multiple congenital melanocytic nevi plus the presence of central nervous system melanosis or melanoma. We report a case of a male infant with a giant posteroaxial nevus and evidence of intracranial melanosis on ultrasound and magnetic resonance imaging.
March 2016: Radiology case reports
https://www.readbyqxmd.com/read/26955158/giant-cerebriform-congenital-cellular-blue-nevus-presenting-as-cutis-verticis-gyrata
#20
Angoori Gnaneshwar Rao, Divya Koppada, M Haritha
No abstract text is available yet for this article.
January 2016: Indian Journal of Dermatology
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