keyword
MENU ▼
Read by QxMD icon Read
search

congenital giant nevus

keyword
https://www.readbyqxmd.com/read/29736211/therapeutic-effects-of-targeting-ras-erk-signaling-in-giant-congenital-melanocytic-nevi
#1
Qingxiong Yu, Min Wu, Lingling Sheng, Qingfeng Li, Feng Xie
Most giant congenital melanocytic nevi (GCMN) exhibit an activating mutation in NRAS. Constitutive activation of the RAS-ERK signaling pathway induces proliferation in nevus cells and plays a pivotal role in melanoma development. In this study, we studied the efficacy of RAS-ERK pathway targeted therapy in GCMN. We isolated nevus cells from GCMN (GNCs) and compared the morphology of GNCs with normal melanocytes and the A375 melanoma cell line. Proliferation curves of GNCs and A375 cells were determined using Cell Counting Kit-8 assays...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29619995/giant-congenital-melanocytic-nevus-associated-with-cerebellar-astrocytoma
#2
Xin Wang, Peng Luo, Harumi Hanazawa, Jia Liu, Long Li, Minghao Wang, Zhitao Jing
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29530698/neurocutaneous-melanosis-in-an-adult-patient-with-intracranial-primary-malignant-melanoma-case-report-and-review-of-the-literature
#3
Mian Ma, Zhi-Liang Ding, Zhi-Qi Cheng, Gang Wu, Xiao-Yu Tang, Peng Deng, Jian-Dong Wu
OBJECTIVE: To explore the clinical characteristics of neurocutaneous melanosis (NCM) in adult patients in order to help improve diagnosis and treatment of this disease. METHODS: We present a rare case of an adult patient suffering from neurocutaneous melanosis with malignant melanoma as well as a review Chinese and English literature, and analyze their clinical features. RESULTS: There were thirty adult NCM patients, aged 19 to 65 years old, average 27...
March 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29515391/giant-congenital-melanocytic-nevi-an-update-and-emerging-therapies
#4
Girish Gulab Meshram, Neeraj Kaur, Kanwaljeet Singh Hura
Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Treatment of GCMN has conventionally been surgical. However, the role of NRAS inhibitors and inactivation of nevus tissue by high hydrostatic pressure are being explored. We present a case of a 1-day-old neonate born with GCMN, along with a review of the literature...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29316280/giant-congenital-melanocytic-nevus-with-vascular-malformation-and-epidermal-cysts-associated-with-a-somatic-activating-mutation-in-braf
#5
Heather C Etchevers, Christian Rose, Birgit Kahle, Helmuth Vorbringer, Frédéric Fina, Pauline Heux, Irina Berger, Benjamin Schwarz, Stéphane Zaffran, Nicolas Macagno, Sven Krengel
Giant congenital melanocytic nevi may be symptomatically isolated or syndromic. Associations with capillary malformations are exceptional, and development of epidermal cysts has not been described. A 71-year-old patient with a giant congenital melanocytic nevus (CMN) of the lower back, buttocks, and thighs was asymptomatic except for unexpected hemorrhage during partial surgical excision years before. Blunt trauma at age 64 initiated recurrent, severe pain under the nevus; multiple large epidermal cysts then developed within it...
May 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29147946/a-case-report-of-the-first-application-of-culture-epithelial-autograft-jace-%C3%A2-for-giant-congenital-melanocytic-nevus-after-its-approval-in-japan
#6
Naoki Morimoto, Natsuko Kakudo, Ayako Kako, Keiko Nishimura, Toshihito Mitsui, Ryohei Miyake, Atsuyuki Kuro, Masakatsu Hihara, Kenji Kusumoto
In Japan, the JACE(®) cultured epidermal autograft (CEA) was approved and covered by public healthcare insurance for use in the treatment of giant congenital melanocytic nevus (GCMN) in 2016. We herein report the results of the application of JACE(®) after curettage and Q-switched ruby laser therapy. The current patient was the first patient with GCMN to be treated with JACE(®) since its approval. A 3-month-old girl had a hairy GCMN of 9.5 cm in diameter from her cheek to her temple on the left side of her face...
November 17, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29138054/keratinocyte-sonic-hedgehog-upregulation-drives-the-development-of-giant-congenital-nevi-via-paracrine-endothelin-1-secretion
#7
Arash Chitsazan, Blake Ferguson, Rehan Villani, Herlina Y Handoko, Pamela Mukhopadhyay, Brian Gabrielli, Wolter J Mooi, H Peter Soyer, Duncan Lambie, Kiarash Khosrotehrani, Grant Morahan, Graeme J Walker
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Here we validate this by studying Cdon knockout mice, and go on to establishing the mechanism by which Shh exacerbates nevogenesis. Cdon knockout mice develop blue nevi without the need for somatic melanocyte oncogenic mutation...
April 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29091921/melanin-pigments-in-the-melanocytic-nevus-regress-spontaneously-after-inactivation-by-high-hydrostatic-pressure
#8
Michiharu Sakamoto, Naoki Morimoto, Chizuru Jinno, Atsushi Mahara, Shuichi Ogino, Shigehiko Suzuki, Kenji Kusumoto, Tetsuji Yamaoka
We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later...
2017: PloS One
https://www.readbyqxmd.com/read/29053515/multiple-tissue-expansion-for-giant-congenital-melanocytic-nevus
#9
Yurema Gonzalez Ruiz, Juan Carlos López Gutiérrez
OBJECTIVE: Tissue expansion is the preferred technique for the treatment of giant congenital melanocytic nevus (GCMN) located on the face, abdomen, and legs. We believe that the use of multiple tissue expanders in the same surgery is a safe and effective technique for the treatment of GCMN. MATERIALS AND METHODS: A total of 14 patients were treated between 2013 and 2016 for GCMN removal with placement in the same surgery of 3 or more tissue expanders. We analyzed esthetic results and complications...
December 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28867912/deep-inferior-epigastric-perforator-free-flaps-for-use-in-complicated-groin-wound-repair-a-case-report-of-severe-groin-scar-contracture-and-review-of-pedicled-and-free-flaps-in-groin-wound-repair
#10
James D Kotick, Roger S Sandelin, Richard D Klein
The use of pedicled and free flaps for tissue transfer and coverage has become a common practice in modern plastic surgery. An area that presents considerable challenge for tissue coverage is the groin. Defects in this area are complicated by issues such as prior surgery; scar contracture; extension of the defect beyond the borders of the groin; radiation damage; high probability of infection; and involvement of vital underlying structures, the genitalia, and perineal and perianal area. Therefore, the choice of donor site and flap usage is often difficult...
August 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/28682723/treating-giant-congenital-nevus-with-integra-dermal-regeneration-template-in-a-9-year-old-girl
#11
Zoran Barcot, Dakovic Bacalja Inga, Bozidar Zupancic, Vedran Bacalja
Integra dermal regeneration template has been well established in treating deep extensive burns, but there are very few cases reported of treating large full-thickness skin defects such as giant nevi. Apart from psychological and cosmetic burdens, the giant congenital nevus carries increased risk of malignant alteration. We present the case of a 9-year-old girl with a giant congenital nevus on her left lower leg. A total excision was done and she was successfully treated with Integra (LifeSciences Corp, Plainsboro, NJ)...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28538892/giant-congenital-melanocytic-nevi-40-years-of-experience-with-the-serial-excision-technique
#12
Lais de Abreu Mutti, Marta Regina Machado Mascarenhas, João Marcos Goes de Paiva, Ronaldo Golcman, Mauro Yoshiaki Enokihara, Benjamin Golcman
Although giant congenital melanocytic nevus is a rare lesion, it causes significant deformity and carries a risk of malignant degeneration. Different surgical techniques for the lesion removal are described, including serial resection, resection with skin grafting, and resection and coverage with expanded skin flap (skin expanders). The aim of this study is to report the author's 40 years of experience with cases requiring at least 4 serial excisions to complete the treatment. Serial resection is an effective, safe, and simple technique that requires a lot of patience...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28508099/giant-congenital-melanocytic-nevi-and-malignant-transformation-a-case-for-early-radical-intervention
#13
Christopher R Maguire, Ryan Livingston, Gael E Phillips, Roy M Kimble
The purpose of this paper is to highlight the risk of early malignant transformation in infants with giant congenital melanocytic nevi (GN) and demonstrate the potential for earlier intervention with aggressive surgery. We describe the case of a child born with a GN who developed a metastatic melanoma early in life, despite early commencement of resection of the nevus. This is contrasted against a second case of a child in which a more radical management was conducted. Despite early commencement of serial resection of the GN, the first child in this series died of metastatic melanoma prior to complete excision of the nevus...
July 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28419495/giant-proliferating-trichilemmal-cyst-arising-from-a-nevus-sebaceus-growing-for-thirty-years
#14
Scott F Lindsey, Divya Aickara, Alexandra Price, Janelle Pavlis, Erin X Wei, George Elgart, Jeong Hee Cho-Vega
Nevus sebaceus of Jadassohn, a congenital cutaneous hamartoma, has the potential to develop into various epidermal adnexal-origin neoplasms. While the most common neoplasms are trichoblastoma or syringocystadenoma, proliferating trichilemmal cysts are exceptionally rare. We report a case of a 63-year-old Cuban male with a giant proliferating trichilemmal cyst arising from a nevus sebaceus on the right shoulder which had been growing for 30 years. Proliferating trichilemmal cysts arising from nevus sebaceus cases are difficult to diagnose clinically and histologically since they are very rare and have not been defined by exact diagnostic criteria...
April 17, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28329507/giant-benign-intradermal-melanocytic-nevus-of-rapid-onset
#15
LETTER
Sarah J Coates, Andrew Avarbock, Garrett T Desman
Benign melanocytic nevi are slowly growing acquiredor congenital tumors with varied morphology,commonly encountered in dermatology clinics. Anytumor with rapid clinical growth must be assessedcarefully in order to exclude malignancy. We report awoman with a histopathologically benign intradermalnevus that presented as a rapidly evolving largecutaneous mass on the ear. Owing to the discrepancybetween the clinical and histopathological findings,an extensive histopathological work-up involvingmany deeper sections, immunohistochemical stains,and fluorescent in situ hybridization (FISH) analysiswas conducted in order to rule out malignancy...
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28254210/giant-congenital-melanocytic-nevus-presenting-as-a-huge-vulvar-mass-a-rare-case
#16
Manu Goyal, Alka Kriplani, Reeta Mahey, Garima Kachhawa, Rajni Yadav, Geetika Singh
No abstract text is available yet for this article.
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28239913/-sky-full-of-stars-pattern-dermoscopic-findings-in-a-desmoplastic-giant-congenital-melanocytic-nevus
#17
Pablo Martín-Carrasco, José Bernabeu-Wittel, Javier Dominguez-Cruz, Teresa Zulueta Dorado, Julian Conejo-Mir Sanchez
Desmoplastic giant congenital melanocytic nevus (DGCN) is an uncommon variant of congenital nevus, presenting as a progressive induration and hypopigmentation of the lesion that occasionally causes hair loss and even total or partial disappearance of the nevus. A 6-month-old girl with a giant congenital melanocytic nevus that involved the entire posterior side of the right thigh was seen in our department. Nine months later, the peripheral area of the nevus presented as a marked induration with hypopigmentation...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28110826/congenital-melanocytic-nevus-syndrome-a-case-series
#18
A Recio, A I Sánchez-Moya, V Félix, Y Campos
Congenital melanocytic nevus syndrome (CMNS) is the result of an abnormal proliferation of melanocytes in the skin and central nervous system caused by progenitor-cell mutations during embryonic development. Mutations in the NRAS gene have been detected in many of these cells. We present 5 cases of giant congenital melanocytic nevus, 3 of them associated with CMNS; NRAS gene mutation was studied in these 3 patients. Until a few years ago, surgery was the treatment of choice, but the results have proved unsatisfactory because aggressive interventions do not improve cosmetic appearance and only minimally reduce the risk of malignant change...
November 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28033154/malignant-melanoma-in-association-with-a-thymic-nevus-in-a-patient-with-a-giant-congenital-nevus
#19
Yulia Shvartser-Beryozkin, Alexander Yakobson, Daniel Benharroch, Milton Saute, Meora Feinmesser
Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma...
July 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27857802/giant-melanocytic-nevi-with-neurocutaneous-melanosis-masquerading-as-neurofibromas
#20
Vykuntaraju K Gowda, Anita Basude, Sahana M Srinivas, Maya Bhat
Neurocutaneous melanosis is congenital melanocytic nevus with neurological manifestations. We report a 4-year-old female child presenting with hyperpigmented and nodular skin lesion associated with developmental delay and convulsions. The child had multiple brownish-black nevi on the face and chest and giant melanocytic nevi on thoraco-abdomen, back, and gluteal region. Computed tomography scan of the brain showed calcification in the pons, right cerebellar hemisphere, and left medial temporal lobe. Skin biopsy done from nodular hyperpigmented site was suggestive of melanocytic nevi...
July 2016: Journal of Pediatric Neurosciences
keyword
keyword
100758
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"