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https://www.readbyqxmd.com/read/28928748/a-peptide-fc-opsonin-with-pan-amyloid-reactivity
#1
James S Foster, Angela D Williams, Sallie Macy, Tina Richey, Alan Stuckey, Daniel Craig Wooliver, Richa Koul-Tiwari, Emily B Martin, Stephen J Kennel, Jonathan S Wall
There is a continuing need for therapeutic interventions for patients with the protein misfolding disorders that result in systemic amyloidosis. Recently, specific antibodies have been employed to treat AL amyloidosis by opsonizing tissue amyloid deposits thereby inducing cell-mediated dissolution and organ improvement. To develop a pan-amyloid therapeutic agent, we have produced an Fc-fusion product incorporating a peptide, p5, which binds many if not all forms of amyloid. This protein, designated Fcp5, expressed in mammalian cells, forms the desired bivalent dimer structure and retains pan-amyloid reactivity similar to the p5 peptide as measured by immunosorbent assays, immunohistochemistry, surface plasmon resonance, and pulldown assays using radioiodinated Fcp5...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28928164/immunopet-of-malignant-and-normal-b-cells-with%C3%A2-89-zr-and%C3%A2-124-i-labeled-obinutuzumab-antibody-fragments-reveals-differential-cd20-internalization-in-vivo
#2
Kirstin A Zettlitz, Richard Tavare, Scott M Knowles, Kristopher K Steward, John M Timmerman, Anna M Wu
PURPOSE: The B-cell antigen CD20 provides a target for antibody-based positron emission tomography (immunoPET). We engineered antibody fragments targeting human CD20 and studied their potential as immunoPET tracers in transgenic mice (huCD20TM) and in a murine lymphoma model expressing human CD20. EXPERIMENTAL DESIGN: Anti-CD20 cys-diabody (cDb) and cys-minibody (cMb) based on rituximab (Rx) and obinutuzumab (GA101) were radioiodinated and used for immunoPET imaging of a murine lymphoma model...
September 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28920557/automated-microspect-microct-image-analysis-of-the-mouse-thyroid-gland
#3
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel Hueng-Yuan Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq, Sissy M Jhiang
<b>Background:</b> The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve <sup>131</sup>I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer. <b>Methods:</b> A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post-injection of <sup>123</sup>I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28911728/protein-kinase-inhibitors-for-the-treatment-of-advanced-and-progressive-radiorefractory-thyroid-tumors-from-the-clinical-trials-to-the-real-life
#4
REVIEW
Antonio Matrone, Laura Valerio, Letizia Pieruzzi, Carlotta Giani, Virginia Cappagli, Loredana Lorusso, Laura Agate, Luciana Puleo, David Viola, Valeria Bottici, Marzia Del Re, Eleonora Molinaro, Romano Danesi, Rossella Elisei
The last ten years have been characterized by the introduction in the clinical practice of new drugs named tyrosine kinase inhibitors for the treatment of several human tumors. After the positive conclusion of two international multicentric, randomized phase III clinical trials, two of these drugs, sorafenib and lenvatinib, have been recently approved and they are now available for the treatment of advanced and progressive radioiodine refractory thyroid tumors. We have been involved in most clinical trials performed with different tyrosine kinase inhibitors in different histotypes of thyroid cancer thus acquiring a lot of experience in the management of both drugs and their adverse events...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28911725/which-patient-with-thyroid-cancer-deserves-systemic-therapy-and-when
#5
REVIEW
Furio Pacini
Distant metastases from differentiated thyroid cancer (DTC) are a rare event, occurring in less than 10% of patients with persistent or recurrent clinical disease. About 50% of these patients do respond to radioiodine (RAI) therapy, either with complete remission or stabilization of the disease on a long term period. Unfortunately, another 50% of these patients are refractory to the treatment with RAI, either from the first appearance of distant metastases or during follow-up. Overall, these patients represent 4-5 new cases/year/million...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28911724/radioactive-iodine-rai-therapy-for-metastatic-differentiated-thyroid-cancer
#6
REVIEW
Frederik A Verburg, Heribert Hänscheid, Markus Luster
Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. It usually has a comparatively benign course. If properly executed, radioiodine therapy can provide an effective treatment of even advanced, metastatic DTC. A major problem in determining the right RAI for a patient with metastatic disease is a comparative lack of evidence. There are no reports on randomized controlled trials in this patient group which can aid us in determining which way to treat which patient. Few non-randomized prospective observational studies have been performed...
June 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28911147/kif5b-ret-rearrangement-in-a-carcinoma-of-the-thyroid-gland-a-case-report-of-a-fatal-disease
#7
David Viola, Carlotta Giani, Salvatore Mazzeo, Clara Ugolini, Raffaele Ciampi, Eleonora Molinaro, Laura Agate, Nicla Borrelli, Antonio Chella, Gabriella Fontanini, Fulvio Basolo, Rossella Elisei
Background: The diffuse sclerosing variant of papillary thyroid cancer (DSV-PTC) is a rare variant of papillary thyroid cancer (PTC) with different clinicopathological features compared with conventional PTC. Case: An advanced DSV-PTC was diagnosed in a 39-year-old man. The radioiodine posttherapeutic whole-body-scan showed only an uptake in the central neck, whereas the computerized tomography showed multiple latero-cervical and mediastinum lymph node metastases, a single and spiculated lung lesion and multiple bilateral cerebellum metastases...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28902736/incidental-131i-activity-in-the-deltoid-region-on-posttherapy-radioiodine-scan
#8
Mark D Strober, Brandon R Callahan
A 71-year-old woman underwent a posttherapy radioiodine scan after I administration for papillary thyroid carcinoma. On day 1 of the posttreatment hospital isolation, the patient received a Pneumovax injection in the left deltoid muscle. A localized hypersensitivity reaction ensued with development of soft tissue edema and erythema at the Pneumovax injection site. This localized reaction persisted up to the subsequent posttherapy radioiodine scan 5 days after injection. Increased activity at the left deltoid region suggests a false-positive finding related to radiotracer sequestration due to inflammation from a localized postvaccination hypersensitivity reaction...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28902733/131i-whole-body-scan-incidental-uptake-due-to-spermatocele
#9
Domenico Albano, Federica Motta, Carla Baronchelli, Silvia Lucchini, Francesco Bertagna
A 46-year-old man with papillary thyroid cancer post total thyroidectomy was referred for post radioiodine (I) whole-body scan. Whole-body images revealed intense I uptake in the bed thyroid and a focal abnormal uptake in the testicular area. Subsequent SPECT/CT demonstrated that the focal uptake corresponded to the left epididymis, and the pathology report revealed a spermatocele with no immunohistochemical features for thyroid tissue. Many cases of unexpected radioiodine uptake have been reported, and spermatocele could be counted for another possibility of incidental I uptake despite an unclear mechanism...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28901480/radioiodine-labeled-anti-epidermal-growth-factor-receptor-binding-bovine-serum-albumin-polycaprolactone-for-targeting-imaging-of-glioblastoma
#10
Chengxia Li, Jian Tan, Jin Chang, Wei Li, Zhongyun Liu, Ning Li, Yanhui Ji
The aim of this study was to look for a new medicine in diagnosing and treating of glioblastoma. Radioiodine-labeled anti-epidermal growth factor receptor (EGFR) binding nanoparticles were constructed. In vitro cell-binding assays were confirmed by confocal microscopy and flow cytometry. Cell cytotoxicity assays were evaluated by MTT assay; radionuclide uptake assays were performed by γ-counter. Radioiodine-imaging studies were conducted using a xenograft nude mouse model in vivo. The results showed that EGFR significantly enhanced the uptake and accumulation of BSA-PCL in the experimental model of xenografts in nude mice, suggesting improved specific nanoparticle-based delivery...
September 4, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28901320/thyroid-carcinoma-in-children-and-adolescents-clinical-characteristics-and-follow-up-from-two-centers
#11
Jing-Jing Pan, Li Zhao, Rui Cheng, Yang Yang, Yu-Hua Hu
AIM OF STUDY: The aim of this study was to analyze the clinical features and outcomes of thyroid carcinoma (TC) in children and adolescent population treated in our institution. MATERIALS AND METHODS: We gathered 43 TC patients 18 years of age or under initial diagnosed between 2009 and 2010 from two hospitals. Patient's clinical characteristics, laboratory tests, and outcomes were collected and analyzed. RESULTS: (1) The incidence of TC is higher in women (2...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28898346/-treatment-of-hyperthyroidism-with-radioiodine-during-hemodialysis-report-of-one-case
#12
Claudia Hurtado, María Soledad Báez, Anabel Bate, Claudio Opazo, Mauricio Troncoso
Although radioiodine (131-I) can be used as treatment of hyperthyroidism for patients in hemodialysis, its use is limited and the experience is mainly related to differentiated thyroid carcinoma. We report a 58 years old female on hemodialysis with recurrent hyperthyroidism after propylthiouracil treatment. She was successfully treated with 131-I and four months after the intervention her euthyroid state was confirmed. We measured 131-I activity in blood, dialysate liquid and other waste products, as well as patient radiation exposure rates...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28895066/the-effect-of-short-term-treatment-with-lithium-carbonate-on-the-outcome-of-radioiodine-therapy-in-patients-with-long-lasting-graves-hyperthyroidism
#13
Vladan Sekulić, Milena Rajić, Marina Vlajković, Slobodan Ilić, Miloš Stević, Marko Kojić
OBJECTIVE: The outcome of radioiodine therapy (RIT) in Graves' hyperthyroidism (GH) mainly depends on radioiodine ((131)I) uptake and the effective half-life of (131)I in the gland. Studies have shown that lithium carbonate (LiCO3) enhances the (131)I half-life and increases the applied thyroid radiation dose without affecting the thyroid (131)I uptake. We investigated the effect of short-term treatment with LiCO3 on the outcome of RIT in patients with long-lasting GH, its influence on the thyroid hormones levels 7 days after RIT, and possible side effects...
September 11, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28894936/thermal-ablation-of-thyroid-nodules-are-radiofrequency-ablation-microwave-ablation-and-high-intensity-focused-ultrasound-equally-safe-and-effective-methods
#14
Yücel Korkusuz, Daniel Gröner, Natascha Raczynski, Oleg Relin, Yasmina Kingeter, Frank Grünwald, Christian Happel
OBJECTIVES: This study compares volume reduction of benign thyroid nodules three months after Radiofrequency Ablation (RFA), Microwave Ablation (MWA) or High Intensity Focused Ultrasound (HIFU) to evaluate which of these methods is the most effective and safe alternative to thyroidectomy or radioiodine therapy. MATERIAL AND METHODS: Ninety-four patients (39 male, 55 female) with a total of 118 benign, symptomatic thyroid nodules were divided into three subgroups...
September 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28894810/sialendoscopy-for-non-stone-disorders-the-current-evidence
#15
REVIEW
Evren Erkul, M Boyd Gillespie
OBJECTIVE: Review the current literature on the use of sialendoscopy in the treatment of non-stone disorders of the major salivary glands. DATA SOURCES: Eligible articles that reported on the use of sialendoscopy in the treatment of non-stone disorders were identified using MEDLINE, Embase, and Google Scholar through May 2016. The search used key words sialendoscopy, salivary endoscopy, salivary scope, salivary duct stenosis, salivary duct stricture, Sjogren's disease, radioiodine sialadenitis, salivary duct obstruction, sialadenitis, chronic sialadenitis, juvenile recurrent parotitis, parotitis, and radiation sialadenitis...
October 2016: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28884426/thyroid-autoimmune-antibodies-in-patients-with-papillary-thyroid-carcinoma-a-double-edged-sword
#16
Chen-Tian Shen, Xin-Yun Zhang, Zhong-Ling Qiu, Zhen-Kui Sun, Wei-Jun Wei, Hong-Jun Song, Quan-Yong Luo
PURPOSE: The relationship between thyroid autoimmunity and thyroid cancer remains controversial. The objective of this study is to comprehensively analyze the association between thyroid autoimmune antibodies and disease statuses of papillary thyroid carcinoma (PTC). METHODS: Patients were divided into different groups according to their final diagnoses after radioiodine therapy as well as their serum anti-thyroglobulin antibody (TgAb) and anti-thyroidperoxidase antibody (TPOAb) titers...
September 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28883260/a-case-of-metastatic-follicular-thyroid-carcinoma-complicated-with-graves-disease-after-total-thyroidectomy
#17
Mariko Aoyama, Hiromitsu Takizawa, Mitsuhiro Tsuboi, Yasushi Nakagawa, Akira Tangoku
Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-old woman underwent right hemithyroidectomy for follicular carcinoma. Metastatic lesions appeared in the lungs and skull two years after the first surgery, and remnant thyroidectomy was performed for radioactive iodine-131 (RAI) therapy, during which the TSH receptor antibody (TRAb) was found to be negative...
September 5, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28878853/bilateral-renal-metastasis-of-h%C3%A3-rthle-cell-thyroid-cancer-with-discordant-uptake-between-i-131-sodium-iodide-and-f-18-fdg
#18
Apichaya Claimon, Minseok Suh, Gi Jeong Cheon, Dong Soo Lee, E Edmund Kim, June-Key Chung
Renal metastasis of thyroid cancer is extremely rare. We report the case of a 62-year-old woman with Hürthle cell thyroid cancer (HCTC) with lungs, bones, and bilateral kidneys metastases. The renal metastatic lesions were clearly demonstrated by (131)I whole body scan (WBS) with SPECT/CT. However, they exhibited false-negative results in (18)F-FDG PET/CT, kidney ultrasonography, and contrast-enhanced CT scan. The findings imply that tumors have low glucose metabolism and are able to accumulate radioiodine, which is not commonly found in the relatively aggressive nature of HCTC...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28878354/japanese-food-data-challenge-the-claimed-link-between-fukushima-s-releases-and-recently-observed-thyroid-cancer-increase-in-japan
#19
Georg Steinhauser, Manuel Chávez-Ortega, Jan-Willem Vahlbruch
Internal, high-dose exposure with radioiodine is known to increase the risk for thyroid cancer in children and adolescents. Ingestion of contaminated food is generally regarded a dominant route of internal exposure. We analyzed the huge data set of the post-Fukushima food monitoring campaign and deployed a conservative model for the estimation of the doses to the general public in a worst-case scenario. Our data suggest that the committed equivalent ingestion doses to the thyroids of the affected Japanese public, even in the utmost conservative approach, remained below the limit on ingestion of radioiodine in foodstuffs and beverages of 50 mSv (as thyroid equivalent dose)...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877833/effect-of-lymph-node-metastasis-on-change-of-positive-thyroglobulin-antibody-in-differentiated-thyroid-carcinoma-after-initial-treatment
#20
Teng Zhang, Li-Ping Song, Teng Zhao, Wen Gao, Yan-Song Lin
Objective To investigate the influence of lymph node metastasis on the change of positive thyroglobulin antibody(TgAb)in differentiated thyroid carcinoma after initial treatment.Methods We retrospectively analyzed the clinical data of 98 differentiated thyroid carcinoma patients with positive TgAb(≥115 IU/ml)before radioiodine(RAI)therapy.All of whom underwent total or near total thyroidectomy,neck lymph node dissection,and subsequent RAI therapy.Patients were divided into negative group(n=83)and non-negative group(n=15)according to the disappearance of positive TgAb or not after a mean follow-up of 21...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
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