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https://www.readbyqxmd.com/read/29160164/rutin-scavenges-reactive-oxygen-species-inactivates-5-adenosine-monophosphate-activated-protein-kinase-ampk-and-increases-nis-expression-in-thyroid-pccl3-cells
#1
Carlos Frederico Lima Gonçalves, Mariana Lopes de Freitas, Rodrigo Soares Fortunato, Leandro Miranda-Alves, Denise Pires de Carvalho, Andrea Claudia Freitas Ferreira
BACKGROUND: Thyroid iodide uptake, mediated by the sodium-iodide symporter (NIS), is essential for thyroid hormone synthesis and also for treatment of thyroid diseases, such as thyroid cancer, through radioiodine therapy. Therefore, compounds able to increase thyroid iodide uptake could be clinically useful, and it is of great importance to unravel the mechanisms underlying such effect. We have previously shown that the flavonoid rutin increases thyroid radioiodide uptake in vivo, in rats...
November 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29158901/dosing-of-radioactive-iodine-in-end-stage-renal-disease-patient-with-thyroid-cancer
#2
Mallika Bhat, Matty Mozzor, Savneek Chugh, Vamsi Buddharaju, Monica Schwarcz, Guy Valiquette
We describe detailed administration of thyroidal and extrathyroidal doses of radioiodine to a patient with end-stage renal disease on hemodialysis. A thorough description of area under curve measurements in a patient with compromised renal function has rarely been described in the literature. Few publications have described thyroid cancer management of patients on hemodialysis, and we believe our management will aid in patient treatment in the future. Learning points: Scheduling of hemodialysis is important when administering radioactive iodine...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29156680/vemurafenib-resistance-via-de-novo-rbm-genes-mutations-and-chromosome-5-aberrations-is-overcome-by-combined-therapy-with-palbociclib-in-thyroid-carcinoma-with-braf-v600e
#3
Zeus A Antonello, Nancy Hsu, Manoj Bhasin, Giovanni Roti, Mukta Joshi, Paul Van Hummelen, Emily Ye, Agnes S Lo, S Ananth Karumanchi, Christine R Bryke, Carmelo Nucera
Purpose: Papillary thyroid carcinoma (PTC) is the most frequent endocrine tumor. BRAF(V600E) represents the PTC hallmark and is targeted with selective inhibitors (e.g. vemurafenib). Although there have been promising results in clinical trials using these inhibitors, most patients develop resistance and progress. Tumor clonal diversity is proposed as one mechanism underlying drug resistance. Here we have investigated mechanisms of primary and secondary resistance to vemurafenib in BRAF(WT/V600E)-positive PTC patient-derived cells with P16(-/-) (CDKN2A(-/-))...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154445/long-term-cardiovascular-morbidity-and-mortality-in-patients-treated-for-differentiated-thyroid-cancer
#4
Nelli Pajamäki, Saara Metso, Tommi Hakala, Tapani Ebeling, Heini Huhtala, Essi Ryödi, Juhani Sand, Arja Jukkola-Vuorinen, Pirkko-Liisa Kellokumpu-Lehtinen, Pia Jaatinen
OBJECTIVE: Thyroid hormone suppression therapy has been widely used in the treatment of thyroid cancer, but concerns have been raised about the cardiovascular risks of this treatment. The objective of this study was to evaluate long-term cardiovascular morbidity and mortality in patients treated for differentiated thyroid cancer (DTC) and to assess the effect of TSH suppression and radioiodine (RAI) treatment on the cardiovascular outcome. DESIGN: Retrospective cohort study...
November 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29154258/prediction-of-dose-to-the-relatives-of-patients-treated-with-radioiodine-131-using-neural-networks
#5
Marzieh Ebrahimi, Mohammad Reza Kardan, Vahid Changizi, Seyed Mahdi Hosseini Pooya, Parham Geramifar
In this study, the effective dose to family members and caregivers of 52 thyroid cancer patients who had been treated with radioiodine I-131 was measured to investigate the ability of neural network for predicting the doses to the relatives. Effectiveness of this method to define the relatives who will receive doses more than 1 mSv was evaluated. The effective doses were measured by TLD. The inputs of neural network were 13 different parameters that potentially could affect the dose and the output was dose to the family members...
November 20, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29144811/concordance-of-preoperative-clinical-stage-with-pathological-stage-in-patients-%C3%A2-45-years-with-well-differentiated-thyroid-cancer
#6
Natalie A Calcatera, Waseem Lutfi, Paritosh Suman, Nicholas R Suss, Chi-Hsiung Wang, Richard A Prinz, David J Winchester, Tricia A Moo-Young
OBJECTIVE: Clinical stage (cStage) in thyroid cancer determines extent of surgical therapy and completeness of resection. Pathologic stage (pStage) is an important determinant of outcome. The rate of discordance between clinical and pathologic stage in thyroid cancer is unknown. METHODS: The National Cancer Data Base (NCDB) was queried to identify 27,473 patients ≥45 years old with cStage I through IV differentiated thyroid cancer undergoing surgery from 2008-2012...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142837/preoperative-management-in-patients-with-graves-disease
#7
REVIEW
Eliana Piantanida
Graves' disease is the most frequent cause of hyperthyroidism in iodine-sufficient geographical areas and is characterized by the presence in patients' serum of autoantibodies directed against the thyrotropin receptor (TRAb) that cause overproduction and release of thyroid hormones. Clinical presentation results from both hyperthyroidism and underlying autoimmunity. The diagnosis is based on characteristic clinical features and biochemical abnormalities. If serum thyrotropin (TSH) is low, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations should be measured to distinguish between subclinical (with normal circulating thyroid hormones) and overt hyperthyroidism (with increased circulating thyroid hormones)...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142833/the-effect-of-long-term-thyroid-stimulating-hormone-suppressive-therapy-on-the-gonadal-steroid-hormones-of-patients-with-thyroid-carcinoma-after-surgery
#8
Xiaoli Liu, Ying Zhou, Nan Liang, Yang Hong, Gianlorenzo Dionigi, Hui Sun
Background: To analyze the effect of long-term thyroid-stimulating hormone (TSH) suppressive therapy on the gonadal hormones and related symptoms in patients after surgery. Methods: From 2008 to 2011, totally 238 patients were recruited, who underwent thyroid surgery and subsequent TSH suppression treatment in Department of thyroid Surgery, China-Japan Union hospital, Jilin University. Then their postoperative follow-up data (3-8 years) were collected, including operational method, pathological diagnosis, whether processed radioiodine therapy and the period/dose of TSH suppression treatment...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142052/early-post-treatment-risk-stratification-of-differentiated-thyroid-cancer-comparison-of-three-high-sensitive-tg-assays
#9
Luca Giovanella, Mauro Imperiali, Frederik A Verburg, Pierpaolo Trimboli
OBJECTIVE: To assess the diagnostic performance of three high-sensitive assays in a cohort of TgAb-negative and TgAb-positive differentiated thyroid cancer (DTC) patients. DESIGN: Retrospective study on prospectively selected DTC patients. METHODS: Serum samples from 154 DTC patients were obtained 6-12 months after radioiodine ablation and tested by Beckman, Roche, BRAHMS Tg and TgAb assays, respectively. Receiver operating characteristics curves for Tg were plotted using outcome over time as benchmark and assay-specific Tg thresholds were obtained for TgAb-negative and TgAb-positive patients...
January 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29140921/response-to-oral-lithium-as-an-adjunctive-therapy-during-radioiodine-treatment-for-hyperthyroidism
#10
Sandip Basu, Amit Abhyankar
No abstract text is available yet for this article.
December 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29140920/oral-lithium-as-an-adjunctive-therapy-during-radioiodine-treatment-for-hyperthyroidism
#11
Emmanuel N B Hammond, Yaw A Amoako, Mboyo-Di-Tamba W H Vangu
No abstract text is available yet for this article.
December 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29137069/graves-disease-following-radioiodine-therapy-for-toxic-adenoma-clinical-case-report
#12
Guohua Shen, Futao Cui, Rui Huang, Anren Kuang
RATIONALE: There is a low risk of developing Graves disease (GD) with elevated thyrotropin receptor antibodies (TRAbs) in patients undergoing radioiodine therapy for toxic adenoma. PATIENT CONCERNS: An old female patient with a history of Hashimoto thyroiditis was referred to our department due to thyrotoxic symptoms. After the administration of radioiodine, a significant remission was achieved. However, after 4 months, she was referred to our department again due to recurrence of hyperthyroid symptoms...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135721/clinical-outcomes-and-prognostic-factors-of-radioiodine-ablation-therapy-for-lymph-node-metastases-from-papillary-thyroid-carcinoma
#13
Xinyu Wu, Hao Gu, Yongju Gao, Bo Li, Ruitai Fan
OBJECTIVE: A total of 118 patients with papillary thyroid carcinoma treated with radioactive iodine for lymph node metastases were analyzed retrospectively between August 2008 and June 2014. We describe the clinical course of these patients and focus on factors associated with lymph node metastases response to iodine-131 (I) treatment. PATIENTS AND METHODS: A total of 118 postoperative papillary thyroid carcinoma patients who underwent I treatment with lymph nodes as the only site of metastasis on whole-body scan (I Rx-WBS) and single-photon emission computed tomography-computed tomography (SPECT-CT) were enrolled...
November 10, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29132262/diastolic-dysfunction-is-common-in-survivors-of-pediatric-differentiated-thyroid-carcinoma
#14
Mariëlle Sanne Klein Hesselink, Gianni Bocca, Yoran M Hummel, Adrienne H Brouwers, Johannes G M Burgerhof, Eveline W C M van Dam, Jourik A Gietema, Bas Havekes, Marry M van den Heuvel-Eibrink, Eleonora P M Corssmit, Leontien Kremer, Romana Netea-Maier, Helena J H van der Pal, Robin Peeters, John Th M Plukker, Cécile M Ronckers, Hanneke M van Santen, Peter van der Meer, Thera P Links, Wim J E Tissing
INTRODUCTION: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation (AF) in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. PATIENTS AND METHODS: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis ≤18 years and follow-up ≥5 years after diagnosis) treated in The Netherlands between 1970 and 2009...
November 13, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29132255/selected-radiation-safety-aspects-including-transportation-and-lodging-after-outpatient-sup-131-sup-i-therapy-for-differentiated-thyroid-cancer
#15
Cristiane Jeyce Gomes-Lima, Di Wu, Pejman H Kharazi, Gauri Khorjekar, Matthew D Ringel, Richard J Vetter, Gary Bloom, Kenneth D Burman, Leonard Wartofsky, Douglas Van Nostrand
BACKGROUND: Whether <sup>131</sup>I treatments for differentiated thyroid cancer (DTC) should be performed as an outpatient or inpatient remains controversial. The objective of this study was to survey selected aspects of radiation safety of patients treated with <sup>131</sup>I for DTC as an outpatient. METHODS: An e-mail invitation was sent to over 15,000 members of ThyCa: Thyroid Cancer Survivors' Association, Inc. to complete a web-based survey on selected aspects of radiation safety regarding their last outpatient <sup>131</sup>I treatment...
November 13, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29127767/marine-lenhart-syndrome-in-two-adolescents-including-one-with-thyroid-cancer-a-case-series-and-review-of-the-literature
#16
REVIEW
Animesh Sharma
BACKGROUND: The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome. Thyroid cancer has been described in several adults, but never in children, with Marine-Lenhart syndrome. This paper discusses the challenges in diagnosis and the unique management of this condition in children, in the context of extant literature. CONTENT: In this case report, two adolescent female patients with Marine-Lenhart syndrome, aged 15 and 16 years, exhibited biochemical evidence of hyperthyroidism, and were found to have unilateral hyperfunctioning thyroid nodules via thyroid scintigraphy...
November 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29126111/second-radioiodine-treatment-limited-benefit-for-differentiated-thyroid-cancer-with-loforegional-persistent-disease
#17
Dania Hirsch, Alexander Gorshtein, Eyal Robenshtok, Hiba Masri-Iraqi, Amit Akirov, Hadar Duskin Bitan, Ilan Shimon, Carlos Benbassat
Purpose: Radioactive iodine (RAI) treatment is often indicated after total thyroidectomy in differentiated thyroid cancer (DTC). However, its role in biochemical or loco-regional persistent DTC is unclear. We aimed to investigate the impact of a second RAI treatment in patients with incomplete response to initial treatment and no evidence of distant metastases. Methods: Patients who underwent at least two RAI treatments over a 20-year period at a tertiary hospital were identified...
November 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29125000/salivary-evaluation-in-radioactive-i-131-treated-patients-with-thyroid-carcinoma
#18
Filipe Ivan Daniel, Luiza Dutra Lima, Liliane Janete Grando, Renata Castro, Elke Annegret K Cordeiro, Claudia Regina Dos Santos
BACKGROUND AND OBJECTIVE: radioiodine treatment (I(131)) used to treat thyroid carcinomas produces side effects (sialadenitis, xerostomia, dysphagia and caries susceptibility) reflecting in a poor patient quality of life. This study aimed to evaluate the effect of I(131) on salivary function and possible oral impairment. MATERIAL AND METHODS: Thirty-seven patients undergoing I(131) were submitted to oral examination, answer questions regarding xerostomia/hyposalivation and collect saliva at three moments (M1: 30-45 days before I(131), M2: 1-2 days after I(131) and M3: 7-10 days after treatment)...
November 10, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29123332/target-or-clear-zirconium-89-labeled-silica-nanoparticles-for-enhanced-cancer-directed-uptake-in-melanoma-a-comparison-of-radiolabeling-strategies
#19
Feng Chen, Kai Ma, Li Zhang, Brian Madajewski, Pat Zanzonico, Sonia Sequeira, Mithat Gonen, Ulrich Wiesner, Michelle S Bradbury
Designing a nanomaterials platform with high target-to-background ratios has long been one of the major challenges in the field of nanomedicine. Here, we introduce a "target-or-clear" multifunctional nanoparticle platform that demonstrates high tumor-targeting efficiency and retention while minimizing off-target effects. Encouraged by the favorable preclinical and clinical pharmacokinetic profiles derived after fine-tuning surface chemical properties of radioiodinated ((124)I, t1/2 = 100.2 h) ultrasmall cRGDY-conjugated fluorescent silica nanoparticles (C dots), we sought to investigate how the biological properties of these radioconjugates could be influenced by the conjugation of radiometals such as zirconium-89 ((89)Zr, t1/2 = 78...
October 10, 2017: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/29121867/successful-pregnancy-without-disease-progression-of-radioiodine-refractory-papillary-thyroid-carcinoma-a-case-report
#20
Yuchen Jin, Min Liu, Lingxiao Cheng, Libo Chen
BACKGROUND: Pregnancy is an unquantifiable risk to accelerate tumor growth of papillary thyroid carcinoma (PTC), and whether pregnancy induces an unfavorable prognosis of radioiodine refractory papillary thyroid carcinoma (RR-PTC) remains unknown. CASE PRESENTATION: We investigated the impact of pregnancy on the prognosis of pulmonary metastases in an RR-PTC woman via a long-term clinical follow-up and consecutive computed tomography examinations and serum tests...
November 9, 2017: BMC Cancer
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