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Sabine Wächter, Alexander I Damanakis, Moritz Elxnat, Silvia Roth, Annette Wunderlich, Frederik A Verburg, Sebastian A Fellinger, Detlef K Bartsch, Pietro Di Fazio
Epigenetic modifications have been identified as being responsible for the de-differentiation of thyroid tissue and its malignant transformation. Cell proliferation inhibitory effects of the pan-deacetylase inhibitors panobinostat, SAHA and Trichostatin A (TSA), the modulation of the sodium iodide symporter (NIS; SLC5A5), thyroid transcription factor 1 (TTF1), high mobility group A2 (HMGA2), and H19 and their putative targeting miRNAs have been evaluated in vitro. The cell viability was measured in five thyroid cancer cell lines (FTC133, TPC1, BCPAP, 8505C, C643) by real time cell analyzer xCELLigence...
March 21, 2018: Journal of Clinical Medicine
Yajing Zhang, Wenjuan Hua, Xiao Zhang, Jun Peng, Jiaqian Liang, Zairong Gao
PURPOSE: This study aimed to identify the predictive value of the low preablation-stimulated thyroglobulin (ps-Tg, <2 ng/ml) for excellent response to radioiodine remnant ablation in differentiated thyroid carcinoma. PATIENTS AND METHODS: A total of 398 consecutive patients who underwent total thyroidectomy and radioactive iodine remnant ablation therapy were reviewed retrospectively. Each patient was risk-stratified using the American Joint Cancer Committee and risk staging systems and using response to the initial therapy reclassification system...
March 19, 2018: Nuclear Medicine Communications
Tamer M Sakr, M H Sanad, Walaa H Abd-Alla, Dina H Salama, Gehan M Saleh
Challenges facing cardiovascular imaging necessitate innovation of better radiopharmaceuticals to augment or replace the existing ones. This research assesses the ability and competency of radioiodinated esmolol as a potential cardio selective imaging agent. Radioiodinated esmolol was synthesized with 97.3 ± 0.3% radiochemical yield and with high stability up to 48 h at room temperature as well as in rat serum. Molecular modeling study was performed to confirm the binding of iodinated esmolol to β1 -adrenergic receptor...
March 9, 2018: Applied Radiation and Isotopes
Jiao Liu, Baoping Liu, Yanxia Yu, Fangfang Chao, Yan Liu, Xingmin Han
OBJECTIVE: In the follow-up of patients with differentiated thyroid cancer (DTC), several patients had elevated serum levels of antithyroglobulin antibody (TgAb), undetectable serum thyroglobulin (Tg), and negative radioiodine whole body scan (131 I-WBS). We describe the use of neck ultrasonography (US) and fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) imaging in these patients to investigate this clinically challenging problem and propose treating...
March 20, 2018: Hellenic Journal of Nuclear Medicine
Marko Barjaktarović, Milica M Janković, Marija Jeremić, Milovan Matović
Radioiodine therapy in the treatment of differentiated thyroid carcinoma (DTC) is used in clinical practice for the ablation of thyroid residues and/or destruction of tumour tissue. Whole-body scintigraphy for visualization of the spatial 131I distribution performed by a gamma camera (GC) is a standard procedure in DTC patients after application of radioiodine therapy. A common problem is the precise topographic localization of regions where radioiodine is accumulated even in SPECT imaging. SPECT/CT can provide precise topographic localization of regions where radioiodine is accumulated, but it is often unavailable, especially in developing countries because of the high price of the equipment...
March 9, 2018: Computers in Biology and Medicine
A Campennì, R M Ruggeri, M Siracusa, S A Pignata, F Di Mauro, A Vento, F Trimarchi, S Baldari
PURPOSE: The aim of the present study was to evaluate the possible diagnostic role of the combined performance of BRAF mutation analysis and MIBI scintigraphy in papillary thyroid cancer (PTC) patients with incomplete bio-chemical response to first radioiodine therapy (RAIT) performed for thyroid remnant ablation. METHODS: The records of 15 PTC patients with bio-chemical incomplete response to first RAIT were retrospectively analyzed. BRAFV600E analysis on primary tumor samples was obtained in all cases along with neck ultrasonography and99m Tc-MIBI scintigraphy of the neck-thorax regions at first follow-up...
March 16, 2018: Journal of Endocrinological Investigation
Ludmila S Almeida, Maidane C Araújo, Denise E Zantut-Wittmann, Lígia V Assumpção, Thiago F Souza, Cleide M Silva, Juliana L Argenton, Allan O Santos, Jair Mengatti, Celso D Ramos, Elba C Etchebehere
BACKGROUND: Radioiodine-refractory thyroid carcinomas (RAIRs) are characterized by reduced expression of sodium-iodine symporter, rising serum thyroglobulin levels, and negative whole-body radioiodine scans. Interestingly, RAIRs continue to express somatostatin receptors and can be identified with Ga-DOTATATE PET/CT imaging. OBJECTIVE: The objective of this study was to compare lesion detectability in Ga-DOTATATE PET/CT performed with elevated thyroid-stimulating hormone (eTSH) levels with suppressed thyroid-stimulating hormone (sTSH) levels...
March 14, 2018: Nuclear Medicine Communications
A F Brovkina, Y N Khionidi
Complications and the frequency of their occurrence as the criteria of eye preservation after brachytherapy (BT) are presented in literature with inconsistencies due to the assessment being done after varied follow-up periods (1 month to 5-10 years). The evaluation of complications occurring after applying radioiodine can be found in literature. The complications after BT beta particle emitting ophthalmic applicators are seldom discussed in articles. PURPOSE: to examine the frequency of complications, the characteristics of their development after choroidal melanoma (CM) brachytherapy with ruthenium ophthalmic applicators (OA) during long-term follow-up and determine the possibility of their prevention...
2018: Vestnik Oftalmologii
Patricia Guyot, Wei Cheng, Gabriel Tremblay, Ronda Copher, Heather Burnett, Xuan Li, Charles Makin
AIM: For dichotomous outcomes, odds ratio (OR) is one of the usual summary measures of indirect treatment comparison. A corresponding number needed to treat (NNT) estimate may facilitate understanding of the treatment effect. METHODS: We show how to estimate NNT based on OR results of a matching adjusted indirect comparison. We also have derived the explicit formula of its 95% CIs by applying the delta method, and as an alternative, a simulation-based method. RESULTS: The method was applied in a case study example in radioiodine-refractory differentiated thyroid cancer (RR-DTC) patients, comparing lenvatinib to sorafenib...
March 2018: Journal of Comparative Effectiveness Research
Zhengyuan Zhou, Satish K Chitneni, Nick Devoogdt, Michael R Zalutsky, Ganesan Vaidyanathan
In a previous study, we evaluated a HER2-specific single domain antibody fragment (sdAb) 2Rs15d labeled with18 F via conjugation of a residualizing prosthetic agent that was synthesized by copper-catalyzed azide-alkyne cycloaddition (CuAAC). In order to potentially increase overall efficiency and decrease the time required for labeling, we now investigate the use of a strain-promoted azide-alkyne cycloaddition (SPAAC) between the 2Rs15d sdAb, which had been pre-derivatized with an azide-containing residualizing moiety, and an18 F-labeled aza-dibenzocyclooctyne derivative...
March 10, 2018: Bioorganic & Medicinal Chemistry
Yang Guang, Yu-Kun Luo, Yan Zhang, Ming-Bo Zhang, Nan Li, Ying Zhang, Jie Tang
Objective To assess the effectiveness and safety of ultrasound-guided percutaneous radiofrequency ablation (RFA) for nonsurgical treatment of metastatic lymph nodes (LNs) in the neck from papillary thyroid carcinoma (PTC). Methods Totally 45 PTC patients who had been treated with total thyroidectomy and radioiodine therapy were enrolled in this retrospective study. A total of 71 metastatic LNs in the neck from PTC were confirmed by percutaneous biopsy. Follow-up consisted of conventional ultrasound,contrast-enhanced ultrasound,and thyroglobulin (Tg) measurement 1,3 and 6 months after RFA and then every 6 months...
February 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Min Liu, Lingxiao Cheng, Yuchen Jin, Maomei Ruan, Shiwei Sheng, Libo Chen
The quantitative relationship between iodine and glucose metabolism in metastases from differentiated thyroid cancer (DTC) remains unknown. Aim of the prospective study was to establish the value of18 F-FDG PET/CT in predicting131 I-avidity of metastases from DTC before the first radioiodine therapy. A total of 121 postoperative DTC patients with elevated stimulated serum thyroglobulin (ssTg) who underwent131 I adjuvant therapy or therapy after18 F-FDG PET/CT scan were enrolled. The Receiver operating characteristic curve was established to create an optimal cut-off point and evaluate the value of SUVmax for predicting131 I-avidity...
March 12, 2018: Scientific Reports
W L Craig, L Smart, S Fielding, C Ramsay, Z H Krukowski
OBJECTIVE: To establish the long term outcomes of risk stratified management of differentiated thyroid cancer (DTC). BACKGROUND: Guidelines for management of DTC lack a strong evidence base and expose patients to overtreatment. This prospective study of patients diagnosed with DTC between 1977 and 2012 describes the long term outcomes of a conservative risk stratified (AMES) management policy. METHODS: Outcomes were analysed around patient and tumour characteristics, primary intervention (surgery ± radioiodine (RAI)), in terms of mortality, recurrence and reintervention...
March 8, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Pingyan Jin, Huijuan Feng, Wei Ouyang, Juqing Wu, Pan Chen, Jing Wang, Yungang Sun, Jialang Xian, Liuhua Huang
Postoperative131 I treatment for differentiated thyroid cancer (DTC) can create a radiation hazard for nearby persons. The present prospective study aimed to investigate radiation dose rates in131 I-treated DTC patients to provide references for radiation protection. A total of 141131 I-treated DTC patients were enrolled, and grouped into a singular treatment (ST) group and a repeated treatment (RT) group. The radiation dose rate of131 I-treated patients was measured. The rate of achieving discharge compliance and restricted contact time were analyzed based on Chinese regulations...
March 10, 2018: Radiation and Environmental Biophysics
Yeon-Hee Han, Hwan-Jeong Jeong, Myung-Hee Sohn, Sun Y Lee, Seok T Lim
BACKGROUND: An elevated thyroid stimulating hormone (TSH) level is essential for the uptake of radioiodine into thyroid remnants and residual thyroid cancer in patients undergoing high-dose radioiodine therapy (HD-RIT). Recently, the use of recombinant human thyroid stimulating hormone (rh- TSH) has increased in preference over the conventional method of thyroid hormone withdrawal (THW). However, the clinical influences of the two methods, aside from the therapeutic effects, have not been widely evaluated...
March 8, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Mahdi Haghighatafshar, Mehrnaz Ghaedian, Zahra Etemadi, Seyed M Entezarmahdi, Tahereh Ghaedian
OBJECTIVE: Although different methods have been suggested on reducing salivary gland radiation after radioiodine administration, an effective preventive or therapeutic measure is still up for debate. The aim of this study was to evaluate the effect of pilocarpine, as a sialagogue drug on the radioiodine content of the salivary gland, and radioiodine-induced symptoms of salivary gland dysfunction. PATIENTS AND METHODS: Patients who were referred for radioiodine therapy were randomized into pilocarpine and placebo groups...
March 6, 2018: Nuclear Medicine Communications
Marcus Ruhlmann, Wilfried Sonnenschein, James Nagarajah, Ina Binse, Ken Herrmann, Walter Jentzen
AIM: The aim of this study was to assess the agreement between predicted blood uptake values using I and actually measured I blood uptake values (reference) in patients with differentiated thyroid carcinoma receiving largely high therapeutic activities. PATIENTS AND METHODS: Fourteen patients were analyzed retrospectively, who underwent a series of both pretherapeutic and intratherapeutic blood sampling using median I activities of 23 MBq and median therapy I activities of 10 GBq...
March 6, 2018: Nuclear Medicine Communications
Fatema Alzahraa Almohamad, Tareq Ahmad, Basel Ahmad, Khalid Hussain, Lama Hadid, Majdi Zein, Mohamad Ahmad
Iodine has always been connected to thyroid gland, and the fact that thyroid tissue traps, organificates and stores iodine more than other tissues is well known, hence the use of radioiodine as a diagnostic and therapeutic tool for thyroid disorders. However, false-positive cases do occur. We present a case of a 34-year-old patient who underwent total thyroidectomy for papillary carcinoma. Results of follow up TSH, thyroglobulin and thyroglobulin antibody tests after surgery lead to two rounds of radioactive iodine...
February 2018: Journal of Surgical Case Reports
Wen Gao, Teng Zhao, Jun Liang, Yansong Lin
CONTEXT: The number of metastatic lymph nodes (LNs) and the ratio of metastatic LN (LR) have been reported as predictors of recurrence in papillary thyroid carcinoma (PTC), while the role of LR or the number of metastatic LNs on the clinical response remains unclear. OBJECTIVE: We aimed to compare the prognostic value of LR and the number of metastatic LNs on clinical response in PTC. DESIGN/SETTING/PATIENTS: A total of 384 PTC patients with LN metastases were enrolled in this study, all of whom underwent total or near total thyroidectomy and subsequent radioiodine ablation...
January 2018: Medicine (Baltimore)
Agata Czarnywojtek, Nadia Sawicka-Gutaj, Izabela Miechowicz, Magdalena Borowska, Kosma Woliński, Maria Teresa Płazińska, Ariadna Zybek-Kocik, Ewa Straburzyńska-Migaj, Małgorzata Zgorzalewicz-Stachowiak, Aleksandra Hernik, Ewelina Szczepanek-Parulska, Marek Ruchała
INTRODUCTION: Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value of the index of distribution of red blood cells volume (RDW) may be a prognostic marker in patients diagnosed with chronic heart failure (CHF). Hypothyroid patients present higher RDW values if compared to healthy controls. Taking into consideration that RDW might be both affected by thyroid status and CHF, we decided to determine the effect of concomitant hypothyroidism following radioiodine therapy (RIT) and CHF on hematological parameters...
March 5, 2018: Endokrynologia Polska
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