keyword
MENU ▼
Read by QxMD icon Read
search

antivirals

keyword
https://www.readbyqxmd.com/read/29679811/hepatitis-c-care-continuum-and-associated-barriers-among-people-who-inject-drugs-in-chennai-india
#1
Eshan U Patel, Sunil S Solomon, Allison M Mcfall, Aylur K Srikrishnan, Amrose Pradeep, Paneerselvam Nandagopal, Oliver Laeyendecker, Aaron A R Tobian, David L Thomas, Mark S Sulkowski, M Suresh Kumar, Shruti H Mehta
BACKGROUND: Little is known regarding barriers to hepatitis C virus (HCV) treatment among people who inject drugs (PWID) in low-resource settings, particularly in the era of direct-acting antiviral therapies. METHODS: Between March, 2015-August, 2016, a cross-sectional survey was administered to community-based PWID in Chennai, India to examine the HCV care continuum and associated barriers. Adjusted prevalence ratios (APR) were estimated by multivariable Poisson regression with robust variance...
April 18, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29679772/efficacy-of-cidofovir-in-treatment-of-bk-virus-induced-hemorrhagic-cystitis-in-post-allogeneic-hematopoietic-cell-transplant-recipients
#2
Eric A Coomes, Amanda Jacques Wolfe, Fotios V Michelis, Dennis Dong-Hwong Kim, Santhosh Thyagu, Auro Viswabandya, Jeffrey H Lipton, Hans A Messner, Uday Deotare
BACKGROUND: BK virus associated hemorrhagic cystitis (BK-HC) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HCT), with incidence up to 70%. Cidofovir is an antiviral agent with growing evidence as a therapeutic intervention. OBJECTIVE: To assess the safety profile and efficacy of intravenous and intravesical cidofovir in allo-HCT patients with BK-HC. METHODS: Retrospective study of the allo-HCT cohort who received cidofovir for symptomatic BK-HC (hematuria with BK viruria or viremia) from January 2010 until March 2017 in a single transplant center in Ontario, Canada...
April 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29679740/dissecting-host-cell-death-programs-in-the-pathogenesis-of-influenza
#3
Jeffrey Downey, Erwan Pernet, François Coulombe, Maziar Divangahi
Influenza A virus (IAV) is a pulmonary pathogen, responsible for significant yearly morbidity and mortality. Due to the absence of highly effective antiviral therapies and vaccine, as well as the constant threat of an emerging pandemic strain, there is considerable need to better understand the host-pathogen interactions and the factors that dictate a protective versus detrimental immune response to IAV. Even though evidence of IAV-induced cell death in human pulmonary epithelial and immune cells has been observed for almost a century, very little is known about the consequences of cell death on viral pathogenesis...
April 18, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29679566/matrix-stiffness-regulate-apoptotic-cell-death-in-hiv-hcv-co-infected-hepatocytes-importance-for-liver-fibrosis-progression
#4
Murali Ganesan, Raghubendra Singh Dagur, Edward Makarov, Larisa I Poluektova, Srivatsan Kidambi, Natalia A Osna
HIV-HCV co-infection causes rapid progression of liver fibrosis. These outcomes to liver cirrhosis can be improved, but not stopped by specific antiviral therapies. Due to high significance of HIV-HCV interactions for morbidity and mortality in co-infected patients, our attention was attracted to the multi-component pathogenesis of fibrosis progression as the transition to end-stage liver disease development. In this study, we hypothesize that increased matrix stiffness enhances apoptosis in HCV-HIV-co-infected hepatocytes and that capturing of apoptotic bodies (AB) derived from these infected hepatocytes by hepatic stellate cells (HSC) drives the fibrosis progression...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679386/hepatitis-b-virus-evasion-from-cgas-sensing-in-human-hepatocytes
#5
Eloi R Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F Baumert
Chronic hepatitis B virus (HBV) infection is a major cause of chronic liver disease and cancer worldwide. The mechanisms of viral genome sensing and the evasion of innate immune responses by HBV infection are still poorly understood. Recently, the cyclic GMP-AMP synthase (cGAS) was identified as a DNA sensor. In this study, we aimed to investigate the functional role of cGAS in sensing of HBV infection and elucidate the mechanisms of viral evasion. We performed functional studies including loss- and gain-of-function experiments combined with cGAS effector gene expression profiling in an infectious cell culture model, primary human hepatocytes and HBV-infected human liver chimeric mice...
April 20, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29679347/pre-emptive-treatment-of-hcv-after-living-donor-liver-transplantation-with-direct-acting-antiviral-agents
#6
Jinmin Jung, Jae Hyun Kwon, Gi-Won Song, Eun-Young Tak, Vavara A Kirchner, Sung-Gyu Lee
BACKGROUND: Hepatitis C virus (HCV) universally recurs after liver transplantation (LT). Although the introduction of direct-acting antiviral agents (DAAs) has revolutionized the treatment of HCV infection, no optimal treatment for HCV recurrence after LT has been developed. METHODS: This study retrospectively evaluated the efficacy of DAAs as a pre-emptive treatment for recurrent HCV infection after living donor liver transplantation (LDLT). From January 2010 to December 2016, 70 patients received pegylated interferon (PegIFN) and 35 patients were treated with DAA-based regimens to treat recurrent HCV after LDLT...
April 20, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29679241/therapeutic-approaches-to-type-i-interferonopathies
#7
REVIEW
Marc Bienias, Normi Brück, Constanze Griep, Christine Wolf, Stefanie Kretschmer, Barbara Kind, Victoria Tüngler, Reinhard Berner, Min Ae Lee-Kirsch
To review recent scientific advances and therapeutic approaches in the expanding field of type I interferonopathies. Type I interferonopathies represent a genetically and phenotypically heterogenous group of disorders of the innate immune system caused by constitutive activation of antiviral type I interferon (IFN). Clinically, type I interferonopathies are characterized by autoinflammation and varying degrees of autoimmunity or immunodeficiency. The elucidation of the underlying genetic causes has revealed novel cell-intrinsic mechanisms that protect the organism against inappropriate immune recognition of self nucleic acids by cytosolic nucleic acid sensors...
April 20, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29678949/hu-antigen-r-regulates-antiviral-innate-immune-responses-through-the-stabilization-of-mrna-for-polo-like-kinase-2
#8
Takuya Sueyoshi, Takumi Kawasaki, Yuichi Kitai, Daisuke Ori, Shizuo Akira, Taro Kawai
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), RIG-I, and melanoma differentiation-associated gene 5 (MDA5) play a critical role in inducing antiviral innate immune responses by activating IFN regulatory factor 3 (IRF3) and NF-κB, which regulates the transcription of type I IFN and inflammatory cytokines. Antiviral innate immune responses are also regulated by posttranscriptional and translational mechanisms. In this study, we identified an RNA-binding protein HuR as a regulator for RLR signaling...
April 20, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29678924/sirnas-and-pirnas-collaborate-for-transposon-control-in-the-two-spotted-spider-mite
#9
Mosharrof Mondal, Kody Mansfield, Alex Flynt
RNAi has revolutionized genetic research, and is being commercialized as an insect pest control technology. Mechanisms exploited for this purpose are antiviral and therefore rapidly evolving. Ideally, RNAi will also be used for non-insect pests, however, differences in RNAi biology makes this uncertain. Tetranychus urticae (two-spotted spider mite) is a destructive non-insect pest, which has a proclivity to develop pesticide resistance. Here we provide a comprehensive study of the endogenous RNAi pathways of spider mites to inform design of exogenous RNAi triggers...
April 20, 2018: RNA
https://www.readbyqxmd.com/read/29678797/subtle-differences-in-selective-pressures-applied-on-the-envelope-gene-of-hiv-1-in-pregnant-versus-non-pregnant-women
#10
Doris G Ransy, Etienne Lord, Martine Caty, Normand Lapointe, Marc Boucher, Abdoulaye Baniré Diallo, Hugo Soudeyns
Pregnancy is associated with modulations of maternal immunity that contribute to foeto-maternal tolerance. To understand whether and how these alterations impact antiviral immunity, a detailed cross-sectional analysis of selective pressures exerted on HIV-1 envelope amino-acid sequences was performed in a group of pregnant (n = 32) and non-pregnant (n = 44) HIV-infected women in absence of treatment with antiretroviral therapy (ART). Independent of HIV-1 subtype, p-distance, dN and dS were all strongly correlated with one another but were not significantly different in pregnant as compared to non-pregnant patients...
April 17, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29678695/the-imd-pathway-regulates-lysozyme-like-proteins-llps-in-the-silkmoth-antheraea-mylitta
#11
Valluri V Satyavathi, Amr A Mohamed, Swetha Kumari, Dadala M Mamatha, Bernard Duvic
Lysozyme-like proteins (LLPs) are members of the glycoside hydrolase family 22 (CAZY GH22). Unlike conventional c-type lysozymes (EC 3.2.1.17), LLPs lack specific catalytic amino acid residues essential for muramidase activity. Previous reports indicated upregulation of LLPs upon bacterial infection in the wild silkworm, Antheraea mylitta as well as in the domesticated silkworm, Bombyx mori. In the present work, we studied the signaling pathways mediating the production of LLPs using RNA interference-mediated knockdown of Spätzle, Relish and STAT, the key regulators of Toll, IMD (Immune deficiency) and JAK/STAT pathways, respectively...
April 17, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29678551/anti-respiratory-syncytial-virus-rsv-g-monoclonal-antibodies-reduce-lung-inflammation-and-viral-lung-titers-when-delivered-therapeutically-in-a-balb-c-mouse-model
#12
Hayat Caidi, Congrong Miao, Natalie J Thornburg, Ralph A Tripp, Larry J Anderson, Lia M Haynes
RSV continues to be a high priority for vaccine and antiviral drug development. Unfortunately, no safe and effective RSV vaccine is available and treatment options are limited. Over the past decade, several studies have focused on the role of RSV G protein on viral entry, viral neutralization, and RSV-mediated pathology. Anti-G murine monoclonal antibody (mAb) 131-2G treatment has been previously shown to reduce weight loss, bronchoalveolar lavage (BAL) cell number, airway reactivity, and Th2-type cytokine production in RSV-infected mice more rapidly than a commercial humanized monoclonal antibody (mAb) against RSV F protein (Palivizumab)...
April 17, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29678533/a-chitinase-from-pacific-white-shrimp-litopenaeus-vannamei-involved-in-immune-regulation
#13
Shengwen Niu, Linwei Yang, Hongliang Zuo, Jiefu Zheng, Shaoping Weng, Jianguo He, Xiaopeng Xu
Chitinases are a group of hydrolytic enzymes that hydrolyze chitin and widely exist in organisms. Studies in mammals have demonstrated that chitinases play important roles in regulation of humoral and cellular immune responses. In arthropods, although it is well known that chitinases are involved in growth, molting and development, the current knowledge on the role of chitinases in immunity, especially in immune regulation, remains largely unknown. In this study, a chitinase (LvChi5) from Litopenaeus vannamei was representatively selected for studying its immune function...
April 17, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29678415/hepatocellular-carcinoma-after-direct-acting-antiviral-agents-can-liver-stiffness-kinetics-help-identify-patients-at-lower-risk
#14
Cristina Rigamonti, Sadahisa Ogasawara
No abstract text is available yet for this article.
March 28, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29678144/interferon-alpha-as-antiviral-therapy-in-chronic-active-epstein-barr-virus-disease-with-interstitial-pneumonia-case-report
#15
Jacek Roliński, Ewelina Grywalska, Aleksandra Pyzik, Michał Dzik, Violetta Opoka-Winiarska, Agata Surdacka, Maciej Maj, Franciszek Burdan, Michał Pirożyński, Piotr Grabarczyk, Elżbieta Starosławska
BACKGROUND: Chronic active Epstein-Barr virus (EBV) disease (CAEBV) is defined as a severe, progressive lymphoproliferative disorder associated with active EBV infection persisting longer than 6 months and developing in patients without recognised immunodeficiency. Rarely, interstitial pneumonitis (IP) occurs as a serious complication in CAEBV patients. The standard therapeutic regimen for IP in CAEBV has not yet been defined. Although interferon alpha (IFN-alpha) is known to suppress viral DNA replication by affecting its basal promoter activation process, it is rarely used in CAEBV patients...
April 20, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29677482/allosteric-ligands-for-the-pharmacologically-important-flavivirus-target-ns5-from-zinc-database-based-on-pharmacophoric-points-free-energy-calculations-and-dynamics-correlation
#16
Abbas Khan, Shoaib Saleem, Muhammad Idrees, Syed Shujait Ali, Muhammad Junaid, Aman Chandra Kaushik, Dong-Qing Wei
Dengue virus belongs to a group of human pathogens, which causes different diseases, dengue hemorrhagic fever and dengue shock syndrome in humans. It possesses RNA as a genetic material and is replicated with the aid of NS5 protein. RNA-dependent RNA polymerase (RdRp) is an important domain of NS5 in the replication of that virus. The catalytic process activity of RdRp is making it an important target for antiviral chemical therapy. To date, No FDA drug has been approved and marketed for the treatment of diseases caused by Dengue virus...
April 11, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29677479/rig-i-and-other-rna-sensors-in-antiviral-immunity
#17
Kwan T Chow, Michael Gale, Yueh-Ming Loo
Pattern recognition receptors (PRRs) survey intra- and extracellular spaces for pathogen-associated molecular patterns (PAMPs) within microbial products of infection. Recognition and binding to cognate PAMP ligand by specific PRRs initiates signaling cascades that culminate in a coordinated intracellular innate immune response designed to control infection. In particular, our immune system has evolved specialized PRRs to discriminate viral nucleic acid from host. These are critical sensors of viral RNA to trigger innate immunity in the vertebrate host...
April 26, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/29677385/identification-and-characterization-of-two-novel-c-type-lectins-from-the-larvae-of-housefly-musca-domestica-l
#18
Jing Zhou, Nai-Nai Fang, Ya Zheng, Kai-Yu Liu, Bin Mao, Li-Na Kong, Ya Chen, Hui Ai
Lectins and antimicrobial peptides (AMPs) are widely distributed in various insects and play crucial roles in primary host defense against pathogenic microorganisms. Two AMPs (cecropin and attacin) have been identified and characterized in the larvae of housefly. In this study, two novel C-type lectins (CTLs) were obtained from Musca domestica, while their agglutinating and antiviral properties were evaluated. Real-time PCR analysis showed that the mRNA levels of four immune genes (MdCTL1, MdCTL2, Cecropin, and Attacin) from M...
April 20, 2018: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29677220/hiv-1-adaptation-studies-reveal-a-novel-env-mediated-homeostasis-mechanism-for-evading-lethal-hypermutation-by-apobec3g
#19
Terumasa Ikeda, Menelaos Symeonides, John S Albin, Ming Li, Markus Thali, Reuben S Harris
HIV-1 replication normally requires Vif-mediated neutralization of APOBEC3 antiviral enzymes. Viruses lacking Vif succumb to deamination-dependent and -independent restriction processes. Here, HIV-1 adaptation studies were leveraged to ask whether viruses with an irreparable vif deletion could develop resistance to restrictive levels of APOBEC3G. Several resistant viruses were recovered with multiple amino acid substitutions in Env, and these changes alone are sufficient to protect Vif-null viruses from APOBEC3G-dependent restriction in T cell lines...
April 20, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29677213/ifn-%C3%AE-and-micrornas-are-important-modulators-of-the-pulmonary-innate-immune-response-against-influenza-a-h1n2-infection-in-pigs
#20
Louise Brogaard, Lars E Larsen, Peter M H Heegaard, Christian Anthon, Jan Gorodkin, Ralf Dürrwald, Kerstin Skovgaard
The innate immune system is paramount in the response to and clearance of influenza A virus (IAV) infection in non-immune individuals. Known factors include type I and III interferons and antiviral pathogen recognition receptors, and the cascades of antiviral and pro- and anti-inflammatory gene expression they induce. MicroRNAs (miRNAs) are increasingly recognized to participate in post-transcriptional modulation of these responses, but the temporal dynamics of how these players of the antiviral innate immune response collaborate to combat infection remain poorly characterized...
2018: PloS One
keyword
keyword
100751
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"