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https://www.readbyqxmd.com/read/29679936/controversies-in-monitoring-metastatic-breast-cancer-during-systemic-treatment-results-of-a-gim-gruppo-italiano-mammella-survey
#1
Bonotto Marta, Basile Debora, Gerratana Lorenzo, Pelizzari Giacomo, Bartoletti Michele, Vitale Maria Grazia, Fanotto Valentina, Lisanti Camilla, Mansutti Mauro, Minisini Alessandro Marco, Aprile Giuseppe, De Laurentiis Michele, Montemurro Filippo, Del Mastro Lucia, Puglisi Fabio
BACKGROUND: The optimal strategy for monitoring metastatic breast cancer (M-MBC) is unclear. Nevertheless, M-MBC influences patient's quality of life and it affects the use of resources in terms of both drugs and diagnostic exam prescription. We aim to disclose oncologists' approach on M-MBC, identifying controversial areas. METHODS: An anonymous online survey was conducted among GIM members who, based on their on-field experience, shared their own method for M-MBC planning...
April 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29679927/excitation-functions-of-proton-and-deuteron-induced-nuclear-reactions-on-natural-iridium-for-the-production-of-191-pt
#2
Honoka Obata, Mayeen Uddin Khandaker, Etsuko Furuta, Kotaro Nagatsu, Ming-Rong Zhang
We studied the excitation functions of residual radionuclides produced via proton and deuteron bombardment on natural iridium in the energy ranges of 30-15 MeV and 50-15 MeV, respectively. A conventional stacked-foil activation technique combined with HPGe γ-ray spectrometry was used to measure the excitation functions for 189, 191 Pt and 189, 190g, 192g, 194g Ir radionuclide production. Theoretical thick target yields were estimated to be 172 MBq/µA h and 192 MBq/µA h via the 193 Ir(p,3n)191 Pt reaction at 29...
March 30, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29679897/the-role-of-eveningness-in-obsessive-compulsive-symptoms-cross-sectional-and-prospective-approaches
#3
Rebecca C Cox, Breanna Tuck, Bunmi O Olatunji
BACKGROUND: Eveningness may be defined as the tendency to be most active and alert during the evening. Previous research has linked eveningness with maladaptive psychological outcomes, and recent evidence has highlighted circadian dysregulation as a novel factor in psychopathology, including obsessive-compulsive disorder (OCD). However, limited research has examined the unique relationship between eveningness and OC symptoms. Two studies were conducted to thoroughly examine the links between eveningness and OC symptoms, while also considering the role of depression symptoms and sleep-related factors...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679875/impurity-profiling-of-varenicline-tartrate-by-lc-qtof-mass-spectrometric-techniques-during-drug-development
#4
Yuting Lu, Xiyang Sun, Fan Song, Lei Wang, Min Song, Taijun Hang
An LC-QTOF-MS method was developed for the separation and characterization of related substances in varenicline tartrate. The separation was established on an InertSustain C18 column (4.6 mm × 150 mm, 5 μm) by liner gradient elution using 0.05% trifluoroacetic acid as mobile phase A and acetonitrile as mobile phase B. The degradation studies were conducted under the ICH prescribed stress conditions. Varenicline tartrate was found to be unstable to alkaline, oxidative, thermal and photolytic stresses, while relatively stable under acid stress condition...
April 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29679874/development-of-an-hplc-uv-method-for-the-evaluation-of-extractables-and-leachables-in-plastic-application-to-a-plastic-packaged-calcium-gluconate-glucoheptonate-solution
#5
Pauline Legrand, Anne Desdion, Gaétan Boccadifuoco, Amélie Dufaÿ Wojcicki, Alan Worsley, Vincent Boudy, Sophie Goulay Dufay
Calcium gluconate glucoheptonate (GGCa) is known to interact with glass containers, leading to the leaching of aluminum from the glass into the solution at toxic level. Therefore, plastic containers seem to be a preferable packaging alternative. Nevertheless, plastics contain potentially toxic additives which could be released into the solution. In order to study content container interaction between GGCa and two plastic containers (polypropylene PP and polyethylene PE containers), an HPLC-PDA method was developed to separate, detect and quantify eleven additives commonly found in plastic materials, with good limit of detection and quantification...
March 21, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29679862/a-small-scale-study-investigating-staff-and-student-perceptions-of-the-barriers-to-a-preventative-approach-for-adolescent-self-harm-in-secondary-schools-in-wales-a-grounded-theory-model-of-stigma
#6
Rachel Parker
OBJECTIVES: Grounded theory analysis of secondary school staff and pupil perceptions about the barriers to preventative work for adolescent self-harm within the secondary school setting in Wales. STUDY DESIGN: Qualitative and grounded theory. METHODS: Two secondary schools in Wales were purposefully sampled for variation. Four group interviews took place using qualitative research methods (Participatory Rapid Appraisal) with six school-based professionals and six students aged more than 16 years...
April 18, 2018: Public Health
https://www.readbyqxmd.com/read/29679848/a-deep-boltzmann-machine-driven-level-set-method-for-heart-motion-tracking-using-cine-mri-images
#7
Jian Wu, Thomas R Mazur, Su Ruan, Chunfeng Lian, Nalini Daniel, Hilary Lashmett, Laura Ochoa, Imran Zoberi, Mark A Anastasio, H Michael Gach, Sasa Mutic, Maria Thomas, Hua Li
Heart motion tracking for radiation therapy treatment planning can result in effective motion management strategies to minimize radiation-induced cardiotoxicity. However, automatic heart motion tracking is challenging due to factors that include the complex spatial relationship between the heart and its neighboring structures, dynamic changes in heart shape, and limited image contrast, resolution, and volume coverage. In this study, we developed and evaluated a deep generative shape model-driven level set method to address these challenges...
April 6, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29679847/deep-learning-in-mammography-and-breast-histology-an-overview-and-future-trends
#8
Azam Hamidinekoo, Erika Denton, Andrik Rampun, Kate Honnor, Reyer Zwiggelaar
Recent improvements in biomedical image analysis using deep learning based neural networks could be exploited to enhance the performance of Computer Aided Diagnosis (CAD) systems. Considering the importance of breast cancer worldwide and the promising results reported by deep learning based methods in breast imaging, an overview of the recent state-of-the-art deep learning based CAD systems developed for mammography and breast histopathology images is presented. In this study, the relationship between mammography and histopathology phenotypes is described, which takes biological aspects into account...
March 26, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29679839/xenon-detection-in-human-blood-analytical-validation-by-accuracy-profile-and-identification-of-critical-storage-parameters
#9
Cécile Frampas, Julia Ney, Mark Coburn, Marc Augsburger, Vincent Varlet
Xenon is a rare, mostly inert, noble gas that has applications in a wide range of fields, including medicine. Xenon acts on the human body as a useful organ-protective and anesthetic agent and has also been previously studied for potential applications in fields such as optics, aerospace and medical imaging. Recently, it was discovered that xenon can boost erythropoietin production, and it has been used as a performance-enhancing agent in international sports competitions such as the Sochi Olympic Games. Therefore, screening methods to detect the misuse of xenon by analysis of biological samples and to monitor anesthesia kinetics and efficiency are being investigated...
April 13, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29679826/improving-the-organic-and-biological-fouling-resistance-and-removal-of-pharmaceutical-and-personal-care-products-through-nanofiltration-by-using-in-situ-radical-graft-polymerization
#10
Yi-Li Lin, Chia-Cheng Tsai, Nai-Yun Zheng
In this study, an insitu radical graft polarization technique using monomers of 3-sulfopropyl methacrylate potassium salt (SPM) and 2-hydroxyethyl methacrylate (HEMA) was applied to a commercial nanofiltration membrane (NF90) to improve its removal of six commonly detected pharmaceutical and personal care products (PPCPs) and mitigate organic and biological fouling by humic acid (HA) and sodium alginate (SA). Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679824/extended-producer-responsibility-and-corporate-performance-effects-of-environmental-regulation-and-environmental-strategy
#11
Benhong Peng, Yu Tu, Ehsan Elahi, Guo Wei
While contemporary manufacturing technologies stimulate the industrial revolution and promote the rapidly changing global economy, it has caused enormous environmental negative externalities and managing the industrial waste remains a primary challenge, especially for fast developing countries such as China. Though existing studies explored the influence of Extended Producer Responsibility (EPR) legislations on environmental externalities, only fewer researches aimed at policy issues. Particularly, the relationship among environmental regulations, environmental strategies and corporate performance in the EPR system has not been deeply investigated...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679792/metacognitive-self-reflectivity-moderates-the-relationship-between-distress-tolerance-and-empathy-in-schizophrenia
#12
Kelsey A Bonfils, Kyle S Minor, Bethany L Leonhardt, Paul H Lysaker
Deficits in empathy seen in schizophrenia are thought to play a major role in the social dysfunction seen in the disorder. However, little work has investigated potential determinants of empathic deficits. This study aimed to fill that gap by examining the effects of two variables on empathy - distress tolerance and metacognitive self-reflectivity. Fifty-four people with schizophrenia-spectrum disorders receiving services at an urban VA or community mental health center were assessed for empathy, metacognition, and distress tolerance...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29679763/leaving-the-nest-improving-food-allergy-management-on-college-campuses
#13
Ashley A Dyer, Amy O'Keefe, Madeleine K Kanaley, Lauren Kao, Ruchi S Gupta
BACKGROUND: The transition from adolescence to young adulthood marks a developmental period where responsibility for management of chronic conditions such as food allergy shifts from the caregiver to the young adult. Fatal food-induced anaphylaxis is most common among adolescents and young adults. However, colleges are currently not well-positioned to provide integrated support for students with food allergies. OBJECTIVE: The study objective was to explore the systems, structures, and policies that currently support students with food allergies at college, assess unmet needs, and develop pilot interventions through the use of patient-centered design processes...
April 18, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29679750/a-fast-and-reliable-dsc-based-method-to-determine-the-monomolecular-loading-capacity-of-drugs-with-good-glass-forming-ability-in-mesoporous-silica
#14
Nele-Johanna Hempel, Katharina Brede, Niels Erik Olesen, Natalja Genina, Matthias Manne Knopp, Korbinian Löbmann
The aim of this study was to introduce a fast and reliable differential scanning calorimetry (DSC)-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica (MS). The proposed method is based on a solvent-free melting/fusion of drug into the MS during a heat-cool-heat cycle in the DSC. Overloaded drug-MS systems were analyzed in the DSC at different drug ratios (50, 60, 70, 80 and 90% w/w) to quantify the excess drug in the (the fraction not adsorbed to the MS surface)...
April 18, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29679747/age-hiv-status-and-research-context-determined-attrition-in-a-longitudinal-cohort-in-nigeria
#15
Eileen O Dareng, Yinka Olaniyan, Sally N Adebamowo, Olabimpe R Eseyin, Michael K Odutola, Elonna M Obiefuna, Richard A Offiong, Paul P Pharoah, Clement A Adebamowo
OBJECTIVE: We explored determinants of attrition a longitudinal cohort study in Nigeria. STUDY DESIGN AND SETTING: We enroled 1,020 women into a prospective study. Of these, 973 were eligible to return for follow-up. We investigated the determinants of attrition among eligible women using a sequential mixed methods design. We used logistic regression models to compare the baseline characteristics of responders and non-responders. At the end of the parent study, we conducted 4 focus group discussions and 8 key informant interviews with non-responders RESULTS: Of the 973 women included in the quantitative analysis, 26% were non-responders...
April 18, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29679738/the-auricular-cartilage-graft-used-as-interpositional-material-for-disc-replacement-after-failed-tmj-operative-arthroscopy
#16
Mario Fernando Muñoz-Guerra, Francisco José Rodríguez-Campo, Manuel Fernández-Domínguez
OBJECTIVES: The aim of this study was to evaluate the preoperative and 2-years postoperative clinical and radiological findings in a group of patients after temporomandibular joint discectomy and interpositional autogenous auricular cartilage graft. MATERIALS AND METHODS: The technique involved a disc removal, condylar remodeling and fixation of the graft to the fossa-eminence region. Preoperative and 2-years postoperative clinical findings and magnetic resonance features were evaluated in a group of 13 patients (fourteen joints)...
April 18, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29679725/achyranthis-bidentatae-radix-enhanced-articular-distribution-and-anti-inflammatory-effect-of-berberine-in-sanmiao-wan-using-an-acute-gouty-arthritis-rat-model
#17
Juan Wu, Jingya Li, Wei Li, Bei Sun, Jin Xie, Wenming Cheng, Qunlin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Sanmiao Wan (SMW) has been a basic prescription employed for the treatment for gout in the clinic since Yuan dynasty. Achyranthis bidentatae radix (ABR) is designed as a lower-guiding drug in SMW to augment the articular accumulation of active ingredients and improve the anti-inflammatory effect. AIM OF THE STUDY: Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR...
April 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29679706/an-elemental-impurities-excipient-database-a-viable-tool-for-ich-q3d-drug-product-risk-assessment
#18
Ruth Boetzel, Agnieszka Ceszlak, Christopher Day, Patrick Drumm, Joan Gil Bejar, John Glennon, Laurence Harris, Crina I Heghes, Radu Horga, Peter L Jacobs, Wilfried J T M Keurentjes, Fiona King, Carlos W Lee, Nancy Lewen, Carol A Marchant, Frans A Maris, William Nye, Samuel Powell, Helmut Rockstroh, Laura Rutter, Mark Schweitzer, Elaine Shannon, Lance Smallshaw, Andrew Teasdale, Sarah Thompson, David Wilkinson
To support the practical implementation of the ICH Q3D guideline, which describes a risk-based approach to the control of elemental impurities in drug products, a consortium of pharmaceutical companies has established a database to collate the results of analytical studies of the levels of elemental impurities within pharmaceutical excipients. This database currently includes the results of 26723 elemental determinations for 201 excipients and represents the largest known, and still rapidly expanding, collection of data of this type...
April 18, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29679704/a-separable-two-dimensional-random-field-model-of-binary-response-data-from-multi-day-behavioral-experiments
#19
Noa Malem-Shinitski, Yingzhuo Zhang, Daniel T Gray, Sara N Burke, Anne C Smith, Carol A Barnes, Demba Ba
BACKGROUND: The study of learning in populations of subjects can provide insights into the changes that occur in the brain with aging, drug intervention, and psychiatric disease. NEW METHOD: We introduce a separable two-dimensional (2D) random field (RF) model for analyzing binary response data acquired during the learning of object-reward associations across multiple days. The method can quantify the variability of performance within a day and across days, and can capture abrupt changes in learning...
April 18, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29679691/newly-developed-endoscopic-detachable-snare-ligation-therapy-for-colonic-diverticular-hemorrhage-a-multicenter-phase-ii-trial-with-videos
#20
Daisuke Akutsu, Toshiaki Narasaka, Katsumasa Kobayashi, Kenji Matsuda, Mariko Wakayama, Yoshinori Hiroshima, Shinji Endo, Takashi Mamiya, Takahisa Watahiki, Kazuto Ikezawa, Hiroyasu Ishida, Mitsuaki Hirose, Yuji Mizokami, Ichinosuke Hyodo
BACKGROUND AND AIMS: We previously reported preliminary safety results for a new method, endoscopic detachable snare ligation (EDSL), for diverticular hemorrhage. This method does not need endoscope removal to attach a ligation device after detection of the bleeding site. The aim of the present study was to evaluate the efficacy and safety of EDSL in a larger patient population. METHODS: This prospective study was conducted in 12 institutions. Patients suspected of having diverticular hemorrhage without serious systemic disease were enrolled...
April 18, 2018: Gastrointestinal Endoscopy
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