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https://www.readbyqxmd.com/read/29055288/osteoinductive-effects-of-cyplexinol-in-the-management-of-osteoporosis-a-case-series
#1
Daniel Tripodi
Aims • A case study was conducted on a subject with a history of documented bone loss and the observed outcome of bone mineral density (BMD) changes when utilizing supplementation with Cyplexinol, a natural bone morphogenetic protein complex. Method and Results • A case of osteoporosis was reviewed with pertinent medical history and dual energy X-ray absorptiometry history described both pre- and postsupplementation. Results demonstrated a significant change in bone density parameter for the individual when the bone support supplement, Cyplexinol, was used...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055281/application-of-wavelet-and-fuorier-transforms-as-powerful-alternatives-for-derivative-spectrophotometry-in-analysis-of-binary-mixtures-a-comparative-study
#2
Said A Hassan, Sherif A Abdel-Gawad
Two signal processing methods, namely, Continuous Wavelet Transform (CWT) and the second was Discrete Fourier Transform (DFT) were introduced as alternatives to the classical Derivative Spectrophotometry (DS) in analysis of binary mixtures. To show the advantages of these methods, a comparative study was performed on a binary mixture of Naltrexone (NTX) and Bupropion (BUP). The methods were compared by analyzing laboratory prepared mixtures of the two drugs. By comparing performance of the three methods, it was proved that CWT and DFT methods are more efficient and advantageous in analysis of mixtures with overlapped spectra than DS...
August 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055278/enhanced-sensitivity-to-detection-nanomolar-level-of-cu-2-compared-to-spectrophotometry-method-by-functionalized-gold-nanoparticles-design-of-sensor-assisted-by-exploiting-first-order-data-with-chemometrics
#3
Zolaikha Rasouli, Raouf Ghavami
A simple, sensitive and efficient colorimetric assay platform for the determination of Cu(2+) was proposed with the aim of developing sensitive detection based on the aggregation of AuNPs in presence of a histamine H2-receptor antagonist (famotidine, FAM) as recognition site. This study is the first to demonstrate that the molar extinction coefficients of the complexes formed by FAM and Cu(2+) are very low (by analyzing the chemometrics methods on the first order data arising from different metal to ligand ratio method), leading to the undesirable sensitivity of FAM-based assays...
October 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055277/structural-photophysical-and-theoretical-studies-of-imidazole-based-excited-state-intramolecular-proton-transfer-molecules
#4
Sivaraman Somasundaram, Eswaran Kamaraj, Su Jin Hwang, Sanghyuk Park
Imidazole-based excited state intramolecular proton transfer (ESIPT) blue fluorescent molecules, 2-(1-(4-chlorophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Cl) and 2-(1-(4-bromophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Br) were designed and synthesized by Debus-Radziszewski method through a one-pot multicomponent reaction in high yield. The synthesized compounds were fully characterized by (1)H NMR, (13)C NMR, FT-IR, FT-Raman, GC-Mass, and elemental analysis. The molecular structures in single crystal lattice were studied by X-ray crystallographic analysis...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055247/optimization-and-validation-of-reverse-phase-hplc-method-for-qualitative-and-quantitative-assessment-of-polyphenols-in-seaweed
#5
Gaurav Rajauria
A simple reverse phase-high performance liquid chromatography (RP-HPLC) coupled to a diode array detector (DAD) and negative ion electrospray mass spectrometer (ESI-MS) method was developed for simultaneous identification and quantification of phenolic antioxidants in seaweed. The proposed method was validated in terms of linearity, limits of detection (LOD), limits of quantification (LOQ), recovery and intermediate precision. The calibration curves were linear with correlation coefficient ranging from 0.9909 to 0...
October 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#6
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055244/a-pilot-study-comparing-mechanical-properties-of-tissue-engineered-cartilages-and-various-endogenous-cartilages
#7
Andrew K Pappa, Sajjad Soleimani, Montserrat Caballero, Alexandra E Halevi, John A van Aalst
BACKGROUND: Mechanical properties of tissue-engineered cartilage and a variety of endogenous cartilage were measured. The main goal was to evaluate if the tissue-engineered cartilage have similar mechanical characteristics to be replaced with rib cartilage in microtia reconstruction. Such study lays the foundation for future human clinical trials for microtia reconstruction. METHOD: Atomic force microscopy and compression testing were used to measure the viscoelasticity of tissue-engineered cartilage (stem cell seeded on Poly lactic co-glycolytic acid nanofibers and Pellet) and endogenous cartilage: conchal bowl, microtic ears, preauricular remnants, and rib...
October 10, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29055221/cage-with-anterior-plating-is-advantageous-over-the-stand-alone-cage-for-segmental-lordosis-in-the-treatment-of-two-level-cervical-degenerative-spondylopathy-a-retrospective-study
#8
Paolo Perrini, Federico Cagnazzo, Nicola Benedetto, Riccardo Morganti, Carlo Gambacciani
OBJECTIVES: To compare retrospectively the clinical and radiological outcomes in cervical spinal alignment after two consecutive levels PEEK cage-assisted ACDF when performed with or without plate fixation PATIENTS AND METHODS: Seventy-eight patients underwent two consecutive levels PEEK cage-assisted ACDF without plating (56 patients) or supplemented with plating (22 patients). The average clinical follow-up was 31.40±12.98months. The authors compared clinical parameters (Neck disability index and Robinson criteria), perioperative parameters (hospital stays, complications), and radiological parameters (global lordotic curvature, segmental lordosis, segmental height)...
October 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29055199/the-removal-of-mercury-ion-pollution-by-using-fe3o4-nanocellulose-synthesis-characterizations-and-dft-studies
#9
Saeid Zarei, Mahmood Niad, Hossein Raanaei
In this study, we have attempted to extract cellulose from Cystoseria myricaas algae. Nanocellulose, Fe3O4 and Fe3O4-nanocellulose compounds are synthesized by acid hydrolysis and co-precipitation as well as sol-gel methods The synthesized compounds are characterized by x-ray diffraction, transmission electron microscopy, particle size distribution (PSD), scanning electron microscopy (SEM),energy dispersive x-ray spectroscopy, vibrating sample magnetometer and Fourier transform infrared spectroscopy. The Hg (II) uptake on Fe3O4-nanocellulose is investigated by 14 isotherm models, 12 kinetic models, adsorption activation energy as well as thermodynamic of adsorption...
October 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29055181/pfa-100-measured-aspirin-resistance-is-the-predominant-risk-factor-for-hospitalized-cardiovascular-events-in-aspirin-treated-patients-a-5-year-cohort-study
#10
H Y Chen, P Chou
WHAT IS KNOWN AND OBJECTIVE: Aspirin therapy is the clinical gold standard for the prevention of cardiovascular events. However, cardiovascular events still develop in some patients undergoing aspirin therapy. Many laboratory methods exist for measuring aspirin resistance. Using the platelet Function Analyzer (PFA)-100 system, we aimed to determine the effect of aspirin resistance on hospitalized cardiovascular events (hCVE) in a 5-year follow-up cohort. We also sought to determine the impact of aspirin resistance on the relationship between common cardiovascular risk factors and cardiovascular hospitalization...
October 21, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29055179/nigella-sativa-oil-protects-the-rat-ovary-from-oxidative-injury-due-to-ischemia-reperfusion
#11
Melahat Atasever, Zeyneb Bakacak
BACKGROUND The aim of this study was to evaluate the effects of Nigella sativa (N. sativa) oil (NSO) on ovarian oxidative damage following ischemia-reperfusion injury, using a rat model of ovarian torsion. MATERIAL AND METHODS Forty-eight female albino Wistar rats were divided into six groups: (Group 1) laparotomy only; (Group 2) intraperitoneal NSO (2 ml/kg), 1 hour following laparotomy; (Group 3) 3 hours of ovarian ischemia; (Group 4) 3 hours of ovarian ischemia followed by 3 hours of reperfusion; (Group 5) 3 hours of ovarian ischemia and 2 ml/kg of NSO 1 hour before laparotomy; (Group 6) 3 hours of reperfusion after 3 hours of ovarian ischemia and 2 ml/mg of NSO 1 hour before laparotomy...
October 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29055171/safer-and-healthier-reduced-nitrites-turkey-meat-sausages-using-lyophilized-cystoseira-barbata-seaweed-extract
#12
Sabrine Sellimi, Abdelkarim Benslima, Ghada Ksouda, Veronique Barragan Montero, Mohamed Hajji, Moncef Nasri
Background Nitrite salts are still common additives in the meat industry. The present study provides a first approach on the employment of the lyophilized aqueous extract (WE) of the Tunisian seaweed Cystoseira barbata for the quality enhancement of turkey meat sausage. Methods WE was supplemented as a natural antioxidant agent to investigate its effectiveness in delaying lipid oxidation turkey meat sausages containing reduced amounts of sodium nitrites. Results On storage day 5, all concentrations of WE (0...
October 21, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29055163/microbial-sensor-for-drug-susceptibility-testing-of-mycobacterium-tuberculosis
#13
Zhi-Tao Zhang, Dian-Bing Wang, Chuan-You Li, Jiao-Yu Deng, Ji-Bin Zhang, Li-Jun Bi, Xian-En Zhang
AIMS: Drug susceptibility testing (DST) of clinical isolates of Mycobacterium tuberculosis (M. tuberculosis) is critical in treating tuberculosis. We demonstrate the possibility of using a microbial sensor to perform DST of M. tuberculosis and shorten the time required for DST. METHODS AND RESULTS: The sensor is made of an oxygen electrode with M. tuberculosis cells attached to its surface. This sensor monitors the residual oxygen consumption of M. tuberculosis cells after treatment with anti-TB drugs with glycerine as a carbon source...
October 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29055149/the-implementation-of-knowledge-dissemination-in-the-prevention-of-occupational-skin-diseases
#14
A Wilke, U Bollmann, S Cazzaniga, A Hübner, S M John, J Karadzinska-Bislimovska, D Mijakoski, D Šimić, D Simon, F Sonsmann, S Stoleski, P Weinert, B Wulfhorst
BACKGROUND: Occupational skin diseases (OSD) have a high medical, social, economic and political impact. Knowledge dissemination from research activities to key stakeholders involved in health care is a prerequisite to make prevention effective. OBJECTIVES: To study and prioritize different activity fields and stakeholders that are involved in the prevention of OSD, to reflect on their inter-relationships, to develop a strategic approach for knowledge dissemination and to develop a hands-on tool for OSD prevention projects METHODS: Seven different activity fields that are relevant in the prevention of OSD have been stepwise identified...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055133/estimating-diversification-rates-for-higher-taxa-bamm-can-give-problematic-estimate-of-rates-and-rate-shifts
#15
Andreas L S Meyer, John J Wiens
Estimates of diversification rates are invaluable for many macroevolutionary studies. Recently, an approach called BAMM (Bayesian Analysis of Macro-evolutionary Mixtures) has become widely used for estimating diversification rates and rate shifts. At the same time, several papers have concluded that estimates of net diversification rates from the method-of-moments (MS) estimators are inaccurate. Yet, no studies have compared the ability of these two methods to accurately estimate clade diversification rates...
October 21, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29055117/can-neutrophil-to-lymphocyte-ratio-predict-late-onset-sepsis-in-preterm-infants
#16
Senem Alkan Ozdemir, Esra Arun Ozer, Ozkan Ilhan, Sumer Sutcuoglu
BACKGROUND: The neutrophil to lymphocyte ratio (NLR) is an easily accessible biomarker that has been reported to represent disease severity in adult trials. The aim of this study was to evaluate the relationship between culture positiveness and NLR in cases where the reason of sepsis was considered, and to foresight an idea about the active agents. METHODS: Preterm infants with birth weights ≤1500 g and/or ≤32 gestational weeks were eligible for this study...
October 21, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29055111/genetic-based-dissection-of-arsenic-accumulation-in-maize-using-a-genome-wide-association-analysis-method
#17
Zhan Zhao, Huaisheng Zhang, Zhongjun Fu, Hao Chen, Yanan Lin, Pengshuai Yan, Weihua Li, Huiling Xie, Zhanyong Guo, Xuehai Zhang, Jihua Tang
Understanding the mechanism of arsenic (As) accumulation in plants is important in reducing As's toxicity to plants and its potential risks to human health. Here, we performed a genome-wide association study to dissect the genetic basis of the As contents of different maize tissues in Xixian, which was irrigated with As-rich surface water, and Changge using an association population consisting of 230 representative inbred maize lines. Phenotypic data revealed a wide normal distribution and high repeatability for the As contents in maize tissues...
October 21, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29055096/an-improved-method-for-bivariate-meta-analysis-when-within-study-correlations-are-unknown
#18
Chuan Hong, Richard D Riley, Yong Chen
Multivariate meta-analysis, which jointly analyzes multiple and possibly correlated outcomes in a single analysis, is becoming increasingly popular in recent years. An attractive feature of the multivariate meta-analysis is its ability to account for the dependence between multiple estimates from the same study. However, standard inference procedures for multivariate meta-analysis require the knowledge of within-study correlations, which are usually unavailable. This limits standard inference approaches in practice...
October 21, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/29055065/simultaneous-determination-of-usnic-diffractaic-evernic-and-barbatic-acids-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-quadrupole-exactive-orbitrap-mass-spectrometry-and-its-application-to-pharmacokinetic-studies
#19
Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang, Changhong Wang
Usnea longissima Ach. (Usnea) has been used in pharmaceuticals, food, cosmetics. Evernic acid (EA), barbatic acid (BA), diffractaic acid (DA), and usnic acid (UA) are the most typical ingredients in U. longissima and exert a wide variety of biological functions. The study aim to develop a sensitive method for simultaneous analysis of EA, BA, DA, and UA in rat plasma and applied to pharmacokinetic studies after consumption of UA and ethanol extract from U. longissima (UE). The samples were separated on BEH C18 column by gradient elution with 0...
October 21, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29055062/cognition-quality-of-life-and-symptom-clusters-in-breast-cancer-using-bayesian-networks-to-elucidate-complex-relationships
#20
Selene Xu, Wesley Thompson, Sonia Ancoli-Israel, Lianqi Liu, Barton Palmer, Loki Natarajan
OBJECTIVE: Breast cancer patients frequently complain of cognitive dysfunction during chemotherapy. Patients also report experiencing a cluster of sleep problems, fatigue and depressive symptoms during chemotherapy. We aimed to understand the complex dynamic interrelationships of depression, fatigue, and sleep to ultimately elucidate their role in cognitive performance and quality of life among breast cancer survivors undergoing chemotherapy treatment. METHODS: Our study sample comprised 74 newly diagnosed stage I-III breast cancer patients scheduled to receive chemotherapy, and followed them for one year...
October 20, 2017: Psycho-oncology
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