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https://www.readbyqxmd.com/read/29457831/low-t3-syndrome-as-a-predictor-of-poor-prognosis-in-chronic-lymphocytic-leukemia
#1
Rui Gao, Rui-Ze Chen, Yi Xia, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Jia-Zhu Wu, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Two hundred and fifty-eight patients with detailed thyroid hormone profile at CLL diagnosis were enrolled. Low T3 syndrome was defined by low free T3 (FT3) level accompanied by normal-to-low free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) levels...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29455365/gender-differences-in-glycemic-control-and-diabetes-related-factors-in-young-adults-with-type-1-diabetes-results-from-the-metro-study
#2
Maria Ida Maiorino, Giuseppe Bellastella, Ofelia Casciano, Michela Petrizzo, Maurizio Gicchino, Mariangela Caputo, Annalisa Sarnataro, Dario Giugliano, Katherine Esposito
PURPOSE: To describe gender differences concerning glycemic control, cardiovascular risk factors, diabetic complications, concomitant pathologies, and circulating endothelial progenitor cells (EPCs), in a population of young adults with type 1 diabetes. METHODS: We collected data from 300 consecutively patients (168 males and 132 females), aged 18-30 years, among those admitted at Diabetes Unit of University of Campania "Luigi Vanvitelli" (Naples, Italy) from March 2012 to January 2017...
February 17, 2018: Endocrine
https://www.readbyqxmd.com/read/29449887/role-of-the-t-and-b-lymphocytes-in-pathogenesis-of-autoimmune-thyroid-diseases
#3
Marta Rydzewska, Michał Jaromin, Izabela Elżbieta Pasierowska, Karlina Stożek, Artur Bossowski
Autoimmune thyroid disorders (AITD) broadly include Graves' disease and Hashimoto's thyroiditis which are the most common causes of thyroid gland dysfunctions. These disorders develop due to complex interactions between environmental and genetic factors and are characterized by reactivity to self-thyroid antigens due to autoreactive lymphocytes escaping tolerance. Both cell-mediated and humoral responses lead to tissue injury in autoimmune thyroid disease. The differentiation of CD4+ cells in the specific setting of immune mediators (for example cytokines, chemokines) results in differentiation of various T cell subsets...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29447027/current-knowledge-of-transient-hypothyroxinemia-of-prematurity-to-treat-or-not-to-treat
#4
Shigeo Iijima
Thyroid hormones (THs) play a critical role in normal maturation of the developing brain in the fetus and infant. Continuing advances in neonatal medicine have contributed to an increased survival of extremely premature infants with neonatal morbidities. In these infants, thyroid system immaturities, as well as morbidity-related thyroid dysfunction, contribute to transient hypothyroxinemia of prematurity (THOP), which is characterized by very low total and free thyroxine and normal or low thyroid stimulating hormone (TSH) levels...
February 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29445911/high-prevalence-of-hcv-gt4-related-tsh-abnormality-among-13402-egyptian-patients-treated-with-direct-acting-antiviral-therapy
#5
Rasha Eletreby, Mohamed Said, Zeinab Abdellatif, Yasmin Saad, Magdy ElSerafy, Hosam Dabes, Kadry ElSaeed, Yehia El-Shazly, Wahid Doss
BACKGROUND: HCV is associated with several extra hepatic diseases including thyroid dysfunction. This study aims at evaluating prevalence of thyroid dysfunction and its possible predictors in a large cohort of HCV GT4-infected patients, and the role of thyroid dysfunction as a predictor of response in the setting of direct acting antivirals (DAAs). METHODS: Patients registered on the web-based registry system to receive therapy for chronic HCV in Beheira governorate viral hepatitis specialized treatment center affiliated to the National committee for control of viral hepatitis (NCCVH), Ministry of health, Egypt in the period from January 2015 to October 2016...
February 14, 2018: Hepatology International
https://www.readbyqxmd.com/read/29442081/qualitative-and-quantitative-salivary-changes-and-subjective-oral-dryness-among-patients-with-thyroid-dysfunction
#6
Meghal Mehul Naik, Vaishnavee Vassandacoumara
Context: There is a paucity of literature regarding the effects of thyroid disorders on the oral cavity by influencing the salivary gland function. Aims: This study aims to understand the qualitative and quantitative changes that thyroid disorder can cause in the salivary function. Settings and Design: After obtaining ethical clearance, 46 consecutive newly diagnosed thyroid dysfunction patients were enrolled in this cross-sectional study, along with 45 age-and sex-matched controls...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29434692/gestational-age-not-transient-hyperthyrotropinemia-impacts-brain-white-matter-diffusion-tensor-imaging-in-premature-infants
#7
Pi-Lien Hung, Chun-Chung Lui, Chen-Chang Lee, Yin-Hsiu Chien, Feng-Shun Chen, Chih-Cheng Chen, Hong-Ren Yu, Mei-Yung Chung, Li-Tung Huang
Transient hypothyroidism is common in premature infants and increases the risk of adverse neurodevelopmental outcomes. Thyroid hormone (TH) is involved in oligodendrocyte development and myelination, however, whether transient hypothyroidism is associated with oligodendrocyte dysplasia and abnormal myelination is unclear. The aim of the present study was to investigate correlations among TH levels, neurodevelopmental outcomes and white matter (WM) microstructure in premature infants. The authors designed a cohort study recruiting 81 premature infants (age, 23-35 weeks)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29430228/routine-treatment-resistant-clostridium-difficile-infection-during-recovery-from-myxedema
#8
Jan K Adamski, Björn B Jäschke, Raija S Uusitalo-Seppälä, Kalle V J Moilanen, Antti V Pehkonen, Wojciech Weigl
Development of the extreme form of hypothyroidism defined as myxedema is very rare. Acute symptoms and their management have been described in detail previously. However, not much attention has been devoted to therapeutic challenges that are faced in the recovery phase of the treatment, especially pertaining to the gastrointestinal system. The link between myxedema and the appearance of severe Clostridium difficile infection (CDI) has not been established so far. A 61-year-old woman with no significant medical record was admitted to hospital because of infected heel pressure and thyroid dysfunction...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29414304/thyroid-hormone-in-the-regulation-of-hepatocellular-carcinoma-and-its-microenvironment
#9
P Manka, J D Coombes, R Boosman, K Gauthier, S Papa, W K Syn
Hepatocellular carcinoma (HCC) commonly arises from a liver damaged by extensive inflammation and fibrosis. Various factors including cytokines, morphogens, and growth factors are involved in the crosstalk between HCC cells and the stromal microenvironment. Increasing our understanding of how stromal components interact with HCC and the signaling pathways involved could help identify new therapeutic and/or chemopreventive targets. It has become increasingly clear that the cross-talk between tumor cells and host stroma plays a key role in modulating tumor growth...
January 29, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29410547/thyroid-dysfunction-in-adult-hematopoietic-cell-transplant-survivors-risks-and-outcomes
#10
Nosha Farhadfar, Marius N Stan, Pankaj Shah, Vikram Sonawane, Mehrdad T Hefazi, Hemant S Murthy, Fay Zou, Xiong Sican, Shahrukh K Hashmi
The incidence and risk factors for thyroid disorders among adult survivors of allogeneic hematopoietic stem cell transplantation (alloHCT) is not well known. This study evaluated incidence and risk factors of thyroid dysfunction in 259 adult alloHCT recipients who had survived for 2 years or more after transplant. Median follow-up was 4.6 years (range; 2.3 to 15.4 years). The 5-year cumulative incidence of thyroid dysfunction was 30.5% (79 of 259 patients). Majority of thyroid abnormalities were observed beyond 2 years after alloHCT...
February 6, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29407446/signaling-pathways-in-thyroid-cancer
#11
Shan Jin, Yun-Tian Yang, Wuyuntu Bao
The morbidity of thyroid cancer is increasing gradually year by year, showing an increasing tendency in nationality, sex, age, tumor size, and tumor staging. The changes of thyroid cell genes, signaling pathways, and related molecular dysfunction promote the occurrence, development, invasion, and metastasis of thyroid cancer. Surgical operation, radioiodine, and endocrinotherapy models can achieve a better prognosis for most patients with thyroid cancer. Although targeted therapeutic drugs bring possible therapeutic opportunities for refractory thyroid cancer, there is a great gap between their predictive value and their actual efficacy...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29407440/thyroid-hormone-in-the-cns-contribution-of-neuron-glia-interaction
#12
Mami Noda
The endocrine system and the central nervous system (CNS) are intimately linked. Among hormones closely related to the nervous system, thyroid hormones (THs) are critical for the regulation of development and differentiation of neurons and neuroglia and hence for development and function of the CNS. T3 (3,3',5-triiodothyronine), an active form of TH, is important not only for neuronal development but also for differentiation of astrocytes and oligodendrocytes, and for microglial development. In adult brain, T3 affects glial morphology with sex- and age-dependent manner and therefore may affect their function, leading to influence on neuron-glia interaction...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29403205/evaluation-of-renal-function-in-subclinical-hypothyroidism
#13
Vijayetha P Patil, Alagilwada S Shilpasree, Vidya S Patil, Kangokar R Pravinchandra, Deepti G Ingleshwar, Axita C Vani
INTRODUCTION: Patients with subclinical hypothyroidism (SCH) have a few or no symptoms or signs of thyroid dysfunction and thus by its very nature, SCH is a laboratory diagnosis. Serum creatinine is elevated and glomerular filtration rate (GFR) values are reversibly reduced in overt hypothyroid patients. We hypothesize that SCH also may be associated with low GFR. AIMS AND OBJECTIVES: The objective of this study was (1) to know the effect of SCH on kidney function, (2) to find the correlation between the renal function parameter creatinine, estimated GFR (eGFR), and thyroid-stimulating hormone (TSH), and (3) to know if creatinine values can be predicted by TSH values in SCH cases...
January 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29396842/associations-between-age-and-50-trace-element-contents-and-relationships-in-intact-thyroid-of-males
#14
Vladimir Zaichick, Sofia Zaichick
BACKGROUND: It is unclear why a prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of trace element contents in thyroid may play important role in goitre- and carcinogenesis of gland. AIM: To examine the variation with age of the mass fraction of 50 trace elements in intact (normal) male thyroid. METHOD: Samples of thyroid parenchyma obtained from 72 healthy males (mean age 37...
February 2, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29396214/hypothyroidism-during-pregnancy-and-its-association-to-perinatal-and-obstetric-morbidity-a-review
#15
María Martínez, Berta Soldevila, Anna Lucas, Inés Velasco, Lluis Vila, Manel Puig-Domingo
There is currently no consensus among the different scientific societies on screening for thyroid dysfunction in the first trimester of pregnancy. Indeed, diagnosis and treatment of subclinical hypothyroidism during pregnancy are controversial, as no cut-off value for thyrotropin (TSH) is universally accepted. TSH measurement may be influenced by different factors throughout pregnancy, but especially during the first trimester. The association between overt hypothyroidism during pregnancy and obstetric and perinatal complications is well established...
February 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29391677/endocrine-abnormalities-in-adolescents-with-menstrual-disorders
#16
Siddhesh R Rajiwade, Haritha Sagili, R Soundravally, L Subitha
Purpose: To look for endocrine abnormalities like thyroid disorders, hyperprolactinemia, hyperandrogenism and PCOS among adolescents with menstrual disorders and to compare the above endocrine status with those without menstrual disorders. Methods: This was a case-control study carried out in adolescent girls aged 10-19 years in gynecology outpatient department of a tertiary care hospital. Sample of venous blood (5 ml) was taken for hormonal studies as clinically indicated-thyroid function test, serum prolactin, total testosterone, which were analyzed by chemiluminescence system...
February 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29390008/age-and-gender-specific-reference-intervals-of-tsh-and-free-t4-in-an-iodine-replete-area-data-from-korean-national-health-and-nutrition-examination-survey-iv-2013-2015
#17
So Young Park, Hae In Kim, Hyun-Kyung Oh, Tae Hyuk Kim, Hye Won Jang, Jae Hoon Chung, Myung-Hee Shin, Sun Wook Kim
BACKGROUND: Establishment of the reference interval of thyroid-stimulating hormone (TSH) is critical in the diagnosis of thyroid dysfunction and is affected by age, gender, iodine nutrition, and ethnicity. The aim of this study was to determine the reference intervals of TSH and free thyroxin (FT4) from a large, nationwide data of Korea where iodine intake is more than adequate. METHODS: We analyzed data from the Korea National Health and Nutrition Examination Survey VI that measured serum TSH, FT4, and thyroid peroxidase antibody from 7,061 individuals (urinary iodine measurement in 6,565)...
2018: PloS One
https://www.readbyqxmd.com/read/29388360/beneficial-effects-of-thyroid-hormone-on-adipose-inflammation-and-insulin-sensitivity-of-obese-wistar-rats
#18
Ana C Panveloski-Costa, Caroline Serrano-Nascimento, Paula Bargi-Souza, Leonice L Poyares, Gabriela de S Viana, Maria T Nunes
Thyroid hormones play an important role in glucose metabolism and there is evidence of increased prevalence of thyroid dysfunction in obese and diabetic patients. This study aimed at evaluating the thyroid function and the effects of the triiodothyronine (T3) treatment on glycemia control, insulin sensitivity and subclinical inflammation in cafeteria-diet-induced obesity in rats. Obesity was induced in male Wistar rats by offering a cafeteria diet and a subset of the obese rats was treated with T3 (1.5 μg per 100 g of body weight) for a 28-day period...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29385933/gestational-impaired-glucose-tolerance-gigt-induced-suppression-of-fetal-thyroid-secretion-effect-on-fetal-outcome
#19
Suganya Shanmugam, Pooja Dhiman, Soundravally Rajendiran, Archana Nimesh, Dilip Kumar Maurya
INTRODUCTION: Gestational impaired glucose tolerance (GIGT) is a milder form of gestational diabetes mellitus (GDM), which is often poorly managed. Although, GDM is known to be associated with increased incidence of thyroid dysfunction, no study has been done to study the effect of GIGT on thyroid status and its effect on fetal outcome. Here, we carried out a study to assess thyroid function and glycemic status in both maternal and cord blood of the subjects with GIGT, and to find their association with the fetal outcome...
January 31, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29385182/association-between-temporomandibular-disorders-chronic-diseases-and-ophthalmologic-and-otolaryngologic-disorders-in-korean-adults-a-cross-sectional-study
#20
Hyun-Seop Song, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Jae-Heung Cho, Koh-Woon Kim, Yeoncheol Park, Hyun Jin Song, Sun-Young Park, Seoyoun Kim, Mia Kim, In-Hyuk Ha
INTRODUCTION: Temporomandibular disorders (TMDs) are common musculoskeletal conditions in the maxillofacial area. Although strong relationships between TMDs and other pain and diseases exist, few studies have comprehensively assessed the association between chronic diseases, ophthalmologic and otolaryngologic disorders and TMD. METHODS: Of 25,534 individuals included in the fifth Korea National Health and Nutrition Examination Survey (2010-2012), 17,575 aged ≥20 years who completed survey items on TMD symptoms were included for cross-sectional analysis...
2018: PloS One
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