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https://www.readbyqxmd.com/read/29666090/rare-case-of-chorea-hyperglycaemia-basal-ganglia-c-h-bg-syndrome
#1
Sajjad Ahmad, Priya Mohan Babu, Lavanya Shenbagaraj, Lindsay George
An 83-year-old woman presented with acute-onset haemichorea and haemiballism particularly affecting the left side of the body. She was known to have type 2 diabetes, which was poorly controlled with sitagliptin. She was hyperglycaemic but not ketotic or acidotic. After she was started on insulin and good glycaemic control was achieved, her abnormal movements dramatically improved. MRI of the brain showed a T1-weighted hyperintense lesion on the right basal ganglia, which is typical of chorea-hyperglycaemia-basal ganglia syndrome...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29665650/selenium-nanoparticles-prevents-lead-acetate-induced-hypothyroidism-and-oxidative-damage-of-thyroid-tissues-in-male-rats-through-modulation-of-selenoenzymes-and-suppression-of-mir-224
#2
Hebatallah Husseini Atteia, Manar Hamed Arafa, Kousalya Prabahar
Selenium nanoparticles (Se-NPs) are customizable drug delivery vehicles that show good bioavailability, higher efficacy and lower toxicity than ordinary Se. Pre-treatment of male rats with these NPs has been recently shown to exert a protective effect against chromium-induced thyroid dysfunction. This study, therefore, aimed to investigate and characterize the potential protective mechanism of Se-NPs against lead (Pb) acetate-induced thyrotoxicity. We found that prophylactic and concurrent treatment of Pb acetate-exposed rats with Nano-Se (0...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29663848/evaluation-of-the-association-between-sexual-dysfunction-and-demyelinating-plaque-location-and-number-in-female-multiple-sclerosis-patients
#3
Volkan Solmaz, Hatice Kose Ozlece, Aydın Him, Ayfer Güneş, Christian Cordano, Durdane Aksoy, Yahya Çelik
Purpose To investigate the frequency of sexual dysfunction (SD) in female multiple sclerosis (MS) patients and to explore its association with the location and number of demyelinating lesions. Material and Methods We evaluated 42 female patients and 41 healthy subjects. All patients underwent neurological examination and 1.5 T brain and full spinal MRI. All subjects completed the female sexual function index (FSFI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Short-Form 36 Quality of Life Scale (SF-36)...
April 17, 2018: Neurological Research
https://www.readbyqxmd.com/read/29662563/-123-i-labeled-oxldl-is-widely-distributed-throughout-the-whole-body-in-mice
#4
Atushi Nakano, Hidekazu Kawashima, Yoshinori Miyake, Tsutomu Zeniya, Akihide Yamamoto, Kazuhiro Koshino, Takashi Temma, Tetsuya Fukuda, Yoshiko Fujita, Akemi Kakino, Shigehiko Kanaya, Tatsuya Sawamura, Hidehiro Iida
Purpose: Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics of radiolabeled oxLDL in mice. Methods: We synthesized 123 I-oxLDL by the iodine monochloride method, and performed an uptake study in CHO cells transfected with lectin-like oxLDL receptor-1 (LOX-1). In addition, we evaluated the consistency between the 123 I-oxLDL autoradiogram and the fluorescence image of DiI-oxLDL after intravenous injection for both spleen and liver...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29661439/frequency-of-thyroid-dysfunction-in-patients-with-diabetes-mellitus-before-and-after-liver-transplantation
#5
A Moura Neto, T G Bovi, C M Righetto, A R Fiore, L T Lot, S R Perales, E C de Ataide, I F S F Boin
BACKGROUND: There is mutual influence between the liver and thyroid hormone metabolism. Patients with diabetes mellitus (DM) also have an increased prevalence of thyroid disorders (TDs). The objectives of this study were to evaluate the frequency of TD before and after liver transplantation (LT) in a population of patients with DM as a whole and when categorized by sex. MATERIALS AND METHODS: This was a retrospective study involving interview and medical record analysis of 46 consecutive patients followed at the diabetes mellitus and liver transplantation unit of a tertiary university hospital...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29652618/transcriptome-network-analysis-reveals-aging-related-mitochondrial-and-proteasomal-dysfunction-and-immune-activation-in-human-thyroid
#6
Byuri Angela Cho, Seong-Keun Yoo, Young Shin Song, Su-Jin Kim, Kyu Eun Lee, Minho Shong, Young Joo Park, Jeong-Sun Seo
BACKGROUND: Elucidating aging-related transcriptomic changes in human organs is necessary to understand the aging physiology and mechanisms, but little is known regarding the thyroid gland. We investigated aging-related transcriptomic alterations in the human thyroid gland and characterized the related molecular functions. METHODS: Publicly available RNA sequencing (RNA-seq) data of 322 thyroid tissue samples from the Genotype-Tissue Expression project were analyzed...
March 20, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29652599/risk-factors-for-new-hypothyroidism-during-tyrosine-kinase-inhibitor-therapy-in-advanced-nonthyroidal-cancer-patients
#7
Melissa G Lechner, Chirag M Vyas, Ole-Petter R Hamnvik, Erik K Alexander, P Reed Larsen, Toni K Choueiri, Trevor E Angell
BACKGROUND: Thyroid dysfunction during tyrosine kinase inhibitor (TKI) cancer treatment is common, but predisposing risk factors have not been determined. Recommendations for monitoring patients treated with one or multiple TKI and in conjunction with other relevant cancer therapies could be improved. The study objective was to assess the risk factors for new thyroid dysfunction in TKI-treated previously euthyroid cancer patients. METHODS: A retrospective cohort study of patients with advanced nonthyroidal cancer treated with TKI from 2000 to 2017, having available thyroid function tests showing initial euthyroid status, excluding patients with preexisting thyroid disease or lack of follow-up thyroid function tests...
April 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29652597/hypothyroidism-during-tyrosine-kinase-inhibitor-therapy-is-associated-with-longer-survival-in-patients-with-advanced-nonthyroidal-cancers
#8
Melissa G Lechner, Chirag M Vyas, Ole-Petter R Hamnvik, Erik K Alexander, P Reed Larsen, Toni K Choueiri, Trevor E Angell
BACKGROUND: Tyrosine kinase inhibitor (TKI)-induced thyroid dysfunction is recognized as a common adverse effect of treatment, but the importance of incident hypothyroidism during TKI therapy remains unclear. This study analyzed the prognostic significance of hypothyroidism during TKI therapy in cancer patients. METHODS: This was a retrospective cohort study of adult patients with advanced nonthyroidal cancer treated with TKI and available thyroid function testing at three affiliated academic hospitals from 2000 to 2017...
April 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29652409/erratum-to-linear-analysis-of-autonomic-activity-and-its-correlation-with-creatine-kinase-mb-in-overt-thyroid-dysfunctions
#9
Manisha Mavai, Yogendra Raj Singh, R C Gupta, Sandeep K Mathur, Bharti Bhandari
[This corrects the article DOI: 10.1007/s12291-017-0659-0.].
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29651216/linear-analysis-of-autonomic-activity-and-its-correlation-with-creatine-kinase-mb-in-overt-thyroid-dysfunctions
#10
Manisha Mavai, Yogendra Raj Singh, R C Gupta, Sandeep K Mathur, Bharti Bhandari
Autonomic activity may be deranged in thyroid dysfunctions and may lead to cardiovascular morbidity and mortality. Myopathy is a common manifestation in thyroid disorders and may be associated with raised serum creatine kinase (CK). We hypothesized that cardiovascular abnormality in thyroid dysfunction may manifest as raised CK-MB. This study was designed to investigate the correlation of CK and its isoform CK-MB with thyroid profile and linear parameters of heart rate variability (HRV). The study was conducted on 35 hypothyroid and hyperthyroid patients each, and 25 age-matched healthy controls...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29645066/intellectual-performance-of-children-of-mothers-with-an-untreated-thyroid-disorder-in-the-first-pregnancy-trimester
#11
Irena Komendová, Sylvie Špitálníková
INTRODUCTION: The focus of the present study was the importance of the mother's thyroid function for foetal development in the first trimester, when the baby is totally dependent on the mother for thyroid hormones. MATERIAL AND METHODS: The study consisted in testing the intellectual performance of children with both euthyroid and thyroid-dysfunction mothers. The experimental group comprised 60 children of mothers with an untreated thyroid disorder in the first trimester of their pregnancy (TSH≥3...
April 12, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29619893/influences-of-anemia-kidney-disease-thyroid-dysfunction-and-liver-disease-on-the-ratio-of-glycated-albumin-to-hemoglobin-a1c
#12
Hiroyasu Miyamoto, Xinran Tao, Takuji Kohzuma, Akihiro Ohnishi
No abstract text is available yet for this article.
April 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29617189/cumulative-burden-of-morbidity-among-testicular-cancer-survivors-after-standard-cisplatin-based-chemotherapy-a-multi-institutional-study
#13
Sarah L Kerns, Chunkit Fung, Patrick O Monahan, Shirin Ardeshir-Rouhani-Fard, Mohammad I Abu Zaid, AnnaLynn M Williams, Timothy E Stump, Howard D Sesso, Darren R Feldman, Robert J Hamilton, David J Vaughn, Clair Beard, Robert A Huddart, Jeri Kim, Christian Kollmannsberger, Deepak M Sahasrabudhe, Ryan Cook, Sophie D Fossa, Lawrence H Einhorn, Lois B Travis
Purpose In this multicenter study, we evaluated the cumulative burden of morbidity (CBM) among > 1,200 testicular cancer survivors and applied factor analysis to determine the co-occurrence of adverse health outcomes (AHOs). Patients and Methods Participants were ≤ 55 years of age at diagnosis, finished first-line chemotherapy ≥ 1 year previously, completed a comprehensive questionnaire, and underwent physical examination. Treatment data were abstracted from medical records. A CBM score encompassed the number and severity of AHOs, with ordinal logistic regression used to assess associations with exposures...
April 4, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29611183/maternal-environment-and-craniofacial-growth-geometric-morphometric-analysis-of-mandibular-shape-changes-with-in-utero-thyroxine-overexposure-in-mice
#14
Matthew J Kesterke, Margaret A Judd, Mark P Mooney, Michael I Siegel, Mohammed Elsalanty, R Nicole Howie, Seth M Weinberg, James J Cray
An estimated 3% of US pregnancies are affected by maternal thyroid dysfunction, with between one and three of every 1000 pregnancies being complicated by overactive maternal thyroid levels. Excess thyroid hormones are linked to neurological impairment and excessive craniofacial variation, affecting both endochondral and intramembranous bone. Using a geometric morphometric approach, this study evaluates the role of in utero thyroxine overexposure on the growth of offspring mandibles in a sample of 241 mice. Canonical variate analysis utilized 16 unilateral mandibular landmarks obtained from 3D micro-computed tomography to assess shape changes between unexposed controls (n = 63) and exposed mice (n = 178)...
April 2, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29610684/immune-toxicity-with-checkpoint-inhibition-for-metastatic-melanoma-case-series-and-clinical-management
#15
Anna J Lomax, Jennifer Lim, Robert Cheng, Arianne Sweeting, Patricia Lowe, Neil McGill, Nicholas Shackel, Elizabeth L Chua, Catriona McNeil
Immune checkpoint inhibitors (anti-PD-1 and anti-CTLA-4 antibodies) are a standard of care for advanced melanoma. Novel toxicities comprise immune-related adverse events (irAE). With increasing use, irAE require recognition, practical management strategies, and multidisciplinary care. We retrospectively evaluated the incidence, kinetics, and management of irAE in 41 patients receiving anti-PD-1 antibody therapy (pembrolizumab) for advanced melanoma. 63% received prior anti-CTLA-4 antibody therapy (ipilimumab)...
2018: Journal of Skin Cancer
https://www.readbyqxmd.com/read/29605392/prediction-of-neonatal-hyperthyroidism
#16
Maïa Banigé, Michel Polak, Dominique Luton
OBJECTIVES: To assess whether it is possible to identify the neonatal predictors of neonatal hyperthyroidism at the presymptomatic stage of the disease. STUDY DESIGN: This retrospective multicenter study in 10 maternity units was based on the medical records of all patients monitored for a pregnancy between January 1, 2007, and January 1, 2014. Among 280 000 births, 2288 medical records of women with thyroid dysfunction were selected and screened. Of these, 415 women had Graves disease and were positive for thyrotropin receptor antibody during pregnancy, and were included...
March 28, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29599204/late-effects-after-hematopoietic-stem-cell-transplantation-for-beta-thalassemia-major-the-french-national-experience
#17
Ilhem Rahal, Claire Galambrun, Yves Bertrand, Nathalie Garnier, Catherine Paillard, Pierre Frange, Corinne Pondarré, Jean Hugues Dalle, Regis Peffault de Latour, Mauricette Michallet, Dominique Steschenko, Despina Moshous, Patrick Lutz, Jean Louis Stephan, Pierre Simon Rohrlich, Ibrahim Yakoub-Agha, Francoise Bernaudin, Christophe Piguet, Nathalie Aladjidi, Catherine Badens, Claire Berger, Gérard Socié, Cécile Dumesnil, Marie Pierre Castex, Marilyne Poirée, Anne Lambilliotte, Caroline Thomas, Pauline Simon, Pascal Auquier, Gerard Michel, Anderson Loundou, Imane Agouti, Isabelle Thuret
In this retrospective study, we evaluate long-term complications in nearly all β-thalassemia-major patients who successfully received, in France, allogeneic hematopoietic stem cell transplantation. 99 patients were analysed with a median age of 5.9 years at transplantation. The median duration of clinical follow-up was 12 years. All conditioning regimen were myeloablative, most often based on busulfan combined with cyclophosphamide and more than 90% of patients underwent a transplant from a matched sibling donor...
March 29, 2018: Haematologica
https://www.readbyqxmd.com/read/29594056/2018-european-thyroid-association-eta-guidelines-for-the-management-of-amiodarone-associated-thyroid-dysfunction
#18
Luigi Bartalena, Fausto Bogazzi, Luca Chiovato, Alicja Hubalewska-Dydejczyk, Thera P Links, Mark Vanderpump
Treatment with amiodarone is associated with changes in thyroid function tests, but also with thyroid dysfunction (amiodarone-induced hypothyroidism, AIH, and amiodarone-induced thyrotoxicosis, AIT). Both AIH and AIT may develop in apparently normal thyroid glands or in the presence of underlying thyroid abnormalities. AIH does not require amiodarone withdrawal, and is treated with levothyroxine replacement if overt, whereas subclinical forms may be followed without treatment. Two main types of AIT are recognized: type 1 AIT (AIT 1), a form of iodine-induced hyperthyroidism occurring in nodular goitres or latent Graves disease, and type 2 AIT (AIT 2), resulting from destructive thyroiditis in a normal thyroid gland...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29590494/endocrinopathies-and-renal-outcomes-in-lithium-therapy-impact-of-lithium-toxicity
#19
R Dineen, D Bogdanet, D Thompson, C J Thompson, L A Behan, A P McKay, G Boran, C Wall, J Gibney, V O'Keane, M Sherlock
Background: Lithium is the mainstay of treatment for bipolar disorder, mania and an augmentation therapy in patients with treatment resistant depression. It has a narrow therapeutic index, with recognized adverse multi-system and endocrine side effects. Aim: To assess the impact of lithium therapy, in particular lithium toxicity, on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland. Study design: A retrospective analysis was performed of the prevalence of lithium toxicity and renal, thyroid and parathyroid dysfunction in our study population...
December 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29590402/benign-thyroid-diseases-and-risk-of-thyroid-cancer-a-nationwide-cohort-study
#20
Cari M Kitahara, Dóra K Rmendiné Farkas, Jens Otto L Jørgensen, Deirdre Cronin-Fenton, Henrik Toft Sørensen
Context: Thyroid nodules, adenomas, and goiter have consistently been associated with thyroid cancer risk. Few studies have assessed whether thyroid dysfunction and thyroid autoimmunity influence this risk. Objective: To examine thyroid cancer risk following diagnoses of a wide range of benign thyroid conditions. Design: Hospital and cancer registry linkage cohort study for the years 1978-2013. Setting: Nationwide (Denmark)...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
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