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https://www.readbyqxmd.com/read/29230334/thyrotoxicosis-associated-with-a-hypopharyngeal-toxic-nodular-thyroid
#1
S Ali Imran, Adam Hinchey, Rob Hart, Martin Bullock, Andrew Ross, Steven Burrell
Ectopic thyroid is a rare developmental anomaly which may be either asymptomatic or present with thyroid dysfunction as well as pressure symptoms. Here we present a novel case of thyrotoxicosis associated with a hypopharyngeal multinodular thyroid in a female. Removal of the ectopic thyroid led to normalization of the thyroid status.
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29229361/a-literature-review-on-maternal-fetal-and-reproductive-disorders-of-toxoplasma-gondii-infection
#2
REVIEW
Shirzad Fallahi, Ali Rostami, Malihe Nourollahpour Shiadeh, Hamed Behniafar, Shahrokh Paktinat
BACKGROUND: Toxoplasma gondii infection is one of the most prevalent infectious disease with worldwide distribution. Congenital toxoplasmosis is annually responsible for 1.20 million disability-adjusted life years around the world, but often it is overlooked many countries. METHODS: We performed an updated review to summarize the current researches on fetal, neonatal and maternal consequences of T. gondii infection and also adverse effects of toxoplasmosis on women reproductive organs...
December 8, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29218227/lessons-learnt-from-a-case-of-missed-central-hypothyroidism
#3
Tessa Glyn, Beverley Harris, Kate Allen
We present the case of a 57-year-old lady who had a delayed diagnosis of central hypothyroidism on a background of Grave's thyrotoxicosis and a partial thyroidectomy. During the twenty years following her partial thyroidectomy, the patient developed a constellation of symptoms and new diagnoses, which were investigated by numerous specialists from various fields, namely rheumatology, renal and respiratory. She developed significantly impaired renal function and raised creatine kinase (CK). She was also referred to a tertiary neurology service for investigation of myositis, which resulted in inconclusive muscle biopsies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29214182/thyroid-dysfunction-among-greek-patients-with-type-1-and-type-2-diabetes-mellitus-as-a-disregarded-comorbidity
#4
Maria E Barmpari, Maria Kokkorou, Anastasia Micheli, Irene Alexiou, Elefteria Spanou, Marina Noutsou, Anastasia Thanopoulou
Introduction: The aim of this study was to determine the prevalence of thyroid dysfunction in Greek patients with type 1 (T1DM) and type 2 (T2DM) diabetes mellitus as well as its possible relations to glycaemic control and to diabetic complications. Methods: A total of 1015 patients, consecutively followed in the Outpatient Diabetes Center, were studied. Anthropometric and biochemical measurements, occurrence of diabetes complications, and classical comorbidities were assessed...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29214084/coexistence-of-primary-hyperaldosteronism-and-graves-disease-a-rare-combination-of-endocrine-disorders-is-it-beyond-a-coincidence-a-case-report-and-review-of-the-literature
#5
S S C Gunatilake, U Bulugahapitiya
Background: Primary hyperaldosteronism is a known cause for secondary hypertension. In addition to its effect on blood pressure, aldosterone exhibits proinflammatory actions and plays a role in immunomodulation/development of autoimmunity. Recent researches also suggest significant thyroid dysfunction among patients with hyperaldosteronism, but exact causal relationship is not established. Autoimmune hyperthyroidism (Graves' disease) and primary hyperaldosteronism rarely coexist but underlying mechanisms associating the two are still unclear...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29212592/-immune-checkpoint-inhibitors-and-endocrinological-side-effects
#6
Line Bisgaard Jørgensen, Lars Bastholt, Knud Yderstræde
Immune checkpoint inhibitors including anti-cytotoxic T-lymphocyte-associated antigen-4 and anti-programmed cell death-1 have revolutionized cancer therapy but have also induced serious immune-related adverse events including hormonal dysfunction. The objective of this review is to characterize the incidence, clinical presentation, management and prognosis of the endocrine-related adverse events including hypophysitis, thyroid dysfunction and diabetes mellitus. Combination therapy is associated with an increased risk of adverse events...
December 4, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29209435/diseases-potentially-related-to-flammer-syndrome
#7
REVIEW
Katarzyna Konieczka, Carl Erb
Flammer syndrome (FS) is a prevalent and mostly benign condition. Subjects with FS seem to have a good life expectancy. Nevertheless, FS subjects are at increased risk for certain diseases, mainly when they are challenged by psychological stress or other stimuli such as coldness. FS is related to ocular diseases, such as normal-tension glaucoma, retinitis pigmentosa, central serous chorioretinopathy, optic nerve compartment syndrome, Leber's hereditary optic neuropathy, arterial or venous occlusions in the retina, and choroid and optic nerve head, despite the absence of classical vascular risk factors...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29197191/post-thyroidectomy-hypoparathyroidism-what-should-we-keep-in-mind
#8
Pietro Caglià, Silvana Puglisi, Antonino Buffone, Salvo Lo Bianco, Valeriya Okatyeva, Massimiliano Veroux, Matteo Angelo Cannizzaro
AIM: Hypoparathyroidism and the resulting hypocalcemia is a common iatrogenic complication following surgical procedures to the neck, and commonly, to the thyroid gland. The aim of this study was to review the available literature to summarize current data related to the development of hypoparathyroidism after thyroid surgery. MATERIALS AND METHODS: An analysis of the surgical literature was performed using the search engine EMBASE and PubMed with particular reference to the principal risk factors related to the post-thyroid surgery hypoparathyroidism...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29193327/effects-of-toceranib-phosphate-on-the-hypothalamic-pituitary-thyroid-axis-in-tumor-bearing-dogs
#9
K R Hume, V L Rizzo, J R Cawley, C E Balkman
BACKGROUND: Thyroid dysfunction is associated with the use of tyrosine kinase inhibitors (TKI) in people. HYPOTHESIS/OBJECTIVES: To determine whether dysfunction in the hypothalamic-pituitary-thyroid axis occurs in dogs receiving the TKI, toceranib phosphate. ANIMALS: Forty-three client-owned dogs with cancer. METHODS: Prospective, observational study. Concentrations of total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), and thyroid-stimulating hormone (TSH) were evaluated on day 0, 30, and 90...
November 30, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29187654/-analysis-for-the-effect-of-different-regimens-on-ocular-myasthenia-gravis-in-children
#10
Chentao Liu, Xia Wang, Lili Xie, Jing Peng, Liwen Wu, Xiangrong Zheng
To evaluate the efficacy, recurrent risk factors and transferable ratio of treatments with 3 different regiments on children with systematic myasthenia gravis (MG).
 Methods: The data of 104 children with ocular MG from June 2010 to March 2014 were collected from Department of Pediatric Neurology of Xiangya Hospital and they were retrospectively studied. The patients were divided into 3 groups: a methylprednisolone group (n=44), a prednisone group (n=48) and a bromine pyridostigmine group (n=12). Evaluative system from American MG foundation was used to evaluate the efficacy of treatment and the ratio of ocular MG transformed into systematic MG...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29187511/pregnancy-outcomes-are-not-altered-by-variation-in-thyroid-function-within-the-normal-range-in-women-free-of-thyroid-disease
#11
Flora Veltri, Pierre Kleynen, Lidia Grabczan, Alexandra Salajan, Serge Rozenberg, Thierry Pepersack, Kris Gustave Poppe
OBJECTIVE: In the recently revised guidelines on the management of thyroid dysfunction during pregnancy, treatment with thyroid hormone (LT4) is not recommended in women without thyroid autoimmunity (TAI) and TSH levels in the range 2.5-4.0 mIU/L, and in a recent study in that particular group of pregnant women, more complications were observed when a treatment with LT4 was given. The objective of the study was therefore to investigate whether variation in thyroid function within the normal (non-pregnant) range in women free of thyroid disease was associated with altered pregnancy outcomes? DESIGN: Cross-sectional data analysis of 1321 pregnant women nested within an ongoing prospective collection of pregnant women's data in a single centre in Brussels, Belgium...
November 29, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29187509/the-spectrum-incidence-kinetics-and-management-of-endocrinopathies-with-immune-checkpoint-inhibitors-for-metastatic-melanoma
#12
Emma Scott, Georgina V Long, Alexander Guminski, Roderick J Clifton-Bligh, Alexander M Menzies, Venessa Hm Tsang
OBJECTIVE: Endocrine immune related adverse events (endocrinopathies) are increasingly prevalent with the use of immune checkpoint inhibitors for the treatment of metastatic melanoma and other malignancies. There are no evidence-based guidelines for the screening or management of such patients. To describe the spectrum, incidence, kinetics, and management of endocrinopathies with immune checkpoint inhibitors. DESIGN: A prospective study conducted at Melanoma Institute Australia between April 2014 to October 2015 Methods: A total of 177 patients were treated with a) ipilimumab (N=15), b) anti-PD-1 (nivolumab, pembrolizumab) (N=103) or c) combination ipilimumab and anti-PD-1 (N=59), and were screened and managed for the subsequent endocrinopathies...
November 29, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29182513/both-hypothyroidism-and-hyperthyroidism-increase-plasma-irisin-levels-in-rats
#13
Emine Atici, Rasim Mogulkoc, Abdulkerim Kasim Baltaci, Esma Menevse
Background A recently discovered hormone, irisin is accepted to be significantly involved in the regulation of body weight. Thyroid functions may be, directly or indirectly, associated with irisin. Aim The aim of the present study is to determine the effect of experimental thyroid dysfunction on irisin levels in rats. Methods The study registered 40 adult male Sprague-Dawley rats, which were allocated to groups as follows: 1. Control; 2. Hypothyroidism induced by injection of 10 mg/kg/day intraperitoneal propylthiouracil (PTU) for 3 weeks; 3...
November 28, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29180492/mild-thyroid-dysfunction-a-potential-target-in-prevention-of-atrial-fibrillation
#14
EDITORIAL
Christian Selmer, Jens Faber
No abstract text is available yet for this article.
November 28, 2017: Circulation
https://www.readbyqxmd.com/read/29175438/gestational-3-3-4-4-5-pentachlorobiphenyl-pcb-126-exposure-disrupts-fetoplacental-unit-fetal-thyroid-cytokines-dysfunction
#15
R G Ahmed
Exposure to polychlorinated biphenyls (PCBs) is related to several endocrine disorders. This study examined the effect of maternal exposure of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the fetoplacental unit and fetal thyroid-cytokine axis during the pregnancy. Pregnant albino rats received PCB 126 (20 or 40μg/kgb.wt.) by oral gavage from gestation day (GD) 1 to 20. Potential effects of PCB 126 were evaluated by following the histopathological changes in the placenta by Haematoxylin and Eosin (H&E) stain and measuring the maternofetal thyroid axis (ELIZA), maternofetal body weight, and fetal growth markers (ELIZA), and cytokines (ELIZA) at embryonic day (ED) 20...
November 21, 2017: Life Sciences
https://www.readbyqxmd.com/read/29174305/perinatal-hypothyroidism-increases-play-behaviors-in-juvenile-rats
#16
Spencer G Smith, Katharine V Northcutt
Thyroid hormones play an instrumental role in the development of the central nervous system. During early development, the fetus is dependent on maternal thyroid hormone production due to the dysfunction of its own thyroid gland. Thus, maternal thyroid dysfunction has been shown to elicit significant abnormalities in neural development, neurochemistry, and behavior in offspring. Previous reports have suggested that human maternal hypothyroidism may increase the chances of having children with autism spectrum disorder and attention-deficit/hyperactivity disorder...
November 21, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29166520/do-you-know-this-syndrome-ascher%C3%A2-s-syndrome-clinical-findings-of-little-known-triad
#17
Carolina Mendonça Gama Donato, Daniel Fernandes Melo, Juliana de Noronha Santos
Ascher's syndrome consists of double lip, blepharochalasis and sometimes non-toxic thyroid enlargement. It is a rare, benign, rarely reported, and sometimes misdiagnosed condition that most often affects patients under 20 years old. The etiology remains unknown, although factors such as trauma, hormonal dysfunction and heredity have been suggested. Treatment based on surgical intervention is indicated to improve aesthetics or function. The presented case shows a patient diagnosed with Ascher's syndrome based on clinical findings such as double lip and blepharochalasis...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166388/associations-between-thyroid-dysfunction-and-developmental-status-in-children-with-excessive-iodine-status
#18
Inger Aakre, Tor A Strand, Khalil Moubarek, Ingrid Barikmo, Sigrun Henjum
BACKGROUND AND OBJECTIVE: Adequate iodine status and normal thyroid hormone synthesis are important for optimal child development. In this study, we explored whether young children's developmental status is associated with thyroid dysfunction in an area of chronic excessive iodine exposure. METHODS: We included 298 children between 18 and 48 months of age residing in Algerian refugee camps. Early child development was measured using the Ages and Stages Questionnaires, third edition (ASQ-3), consisting of five domains: Communication, Gross Motor, Fine Motor, Problem Solving and Personal-Social...
2017: PloS One
https://www.readbyqxmd.com/read/29162475/-thyrotropin-reference-ranges-during-pregnancy-in-the-province-of-huelva-spain
#19
A Ortega Carpio, I Vázquez Rico, M A Castaño López, L Duarte González, M Montilla Álvaro, A Ruiz Reina
OBJECTIVE: The correct diagnosis of hypothyroidism during pregnancy requires knowledge of the local trimester-specific thyrotropin (TSH) reference ranges. When these are not available, the guidelines recommend upper limits of 2.5, 3.0, and 3.0μU/ml for the 1(st), 2(nd), and 3(rd) trimesters, respectively. The aim is to establish the reference range for our local population. MATERIAL AND METHODS: A population-based observational study was performed on healthy pregnant women from 11 healthcare centres in the province of Huelva...
November 18, 2017: Semergen
https://www.readbyqxmd.com/read/29161744/thyroid-dysfunction-states-and-incident-cardiovascular-events-the-tehran-thyroid-study
#20
Maryam Tohidi, Arash Derakhshan, Samaneh Akbarpour, Atieh Amouzegar, Ladan Mehran, Aidin Baghbani-Oskouei, Fereidoun Azizi, Farzad Hadaegh
No abstract text is available yet for this article.
November 21, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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