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RANDOMIZED CONTROLLED TRIAL
Kombo F N'guessan, Kawthar Machmach, Isabella Swafford, Margaret C Costanzo, Lindsay Wieczorek, Dohoon Kim, Siriwat Akapirat, Victoria R Polonis, Punnee Pitisuttithum, Sorachai Nitayaphan, Sanjay Gurunathan, Faruk Sinangil, Suwat Chariyalertsak, Julie A Ake, Robert J O'connell, Sandhya Vasan, Dominic Paquin-Proulx
The RV144 Thai phase III clinical trial's canarypox-protein HIV vaccine regimen showed modest efficacy in reducing infection. We therefore sought to determine the effects of vaccine administration on innate cell activation and subsequent associations with vaccine-induced immune responses. RV306 was a randomized, double-blind clinical trial in HIV-uninfected Thai adults that tested delayed boosting following the RV144 regimen. PBMC collected from RV306 participants prior to and 3 days after the last boost were used to investigate innate immune cell activation...
2024: Frontiers in Immunology
#22
REVIEW
Adishwar Rao, Akriti Agrawal, Gautam Borthakur, Venkata Lokesh Battula, Abhishek Maiti
γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. AML shows high expression of phosphoantigens and UL-16 binding proteins that activate the Vδ2 and Vδ1 subtypes of γδ T cells, respectively, leading to γδ T cell-mediated cytotoxicity...
February 27, 2024: Journal for Immunotherapy of Cancer
#23
JOURNAL ARTICLE
Julian J Freen-van Heeren
In a recent PNAS article, Guo et al. investigate γδ T cell antigen specificity in mice and humans, in which they show that γδ T cell antigen specificity is not constrained to one epitope. Rather, γδ T cells recognize a broad range of diverse antigens containing similar chemical structures or properties. In this News and Views, the importance of γδ T cell antigen polyspecificity during immune responses is highlighted.
February 27, 2024: Journal of Leukocyte Biology
#24
JOURNAL ARTICLE
Hugo Peslier, Julien Reichart, Charles Boursot, Kevin Cohen-Tannugi, Franck Lacoeuille
Gamma/delta T-cell lymphoma is a rare and aggressive subtype of primary cutaneous lymphoma. Clinical manifestations typically include the development of subcutaneous nodules and ulcerated plaques. Some forms present as panniculitis with hemophagocytic syndrome. Prognosis is bleak, with a 10% 5-year survival rate. In this report, we present the case of a 20-year-old man from French Polynesia, referred for 18F-FDG PET/CT because of the progressive worsening of febrile cutaneous-mucosal infiltration on the face persisting for 1 month...
February 23, 2024: Clinical Nuclear Medicine
#25
JOURNAL ARTICLE
Haofuzi Zhang, Jidong Sun, Peng Zou, Yutao Huang, Qiuzi Yang, Zhuoyuan Zhang, Peng Luo, Xiaofan Jiang
BACKGROUND: The immune microenvironment and hypoxia play crucial roles in the pathophysiology of ischemic stroke (IS). Hence, in this study, we aimed to identify hypoxia- and immune-related biomarkers in IS. METHODS: The IS microarray dataset GSE16561 was examined to determine differentially expressed genes (DEGs) utilizing bioinformatics-based analysis. The intersection of hypoxia-related genes and DEGs was conducted to identify differentially expressed hypoxia-related genes (DEHRGs)...
February 29, 2024: Heliyon
#26
JOURNAL ARTICLE
L B Nabors, L S Lamb, T Goswami, K Rochlin, S L Youngblood
Cellular therapies, including chimeric antigen receptor T cell therapies (CAR-T), while generally successful in hematologic malignancies, face substantial challenges against solid tumors such as glioblastoma (GBM) due to rapid growth, antigen heterogeneity, and inadequate depth of response to cytoreductive and immune therapies, We have previously shown that GBM constitutively express stress associated NKG2D ligands (NKG2DL) recognized by gamma delta (γδ) T cells, a minor lymphocyte subset that innately recognize target molecules via the γδ T cell receptor (TCR), NKG2D, and multiple other mechanisms...
2024: Frontiers in Immunology
#27
JOURNAL ARTICLE
F Yang, N Zhang, G-Y Ou, S-W Xu
BACKGROUND: Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, accompanied by cognitive and memory impairment, accounting for about 60% - 80% of dementia types. The pathogenesis of AD has not been clarified, and there is no effective therapy to prevent or treat AD. In this study, we aimed to identify the potential biomarkers involved in the brain immune microenvironment in AD. METHODS: AD datasets from GEO database were obtained to identify the differentially expressed disease-related genes (DEDRGs) in AD through weighted gene co-expression network analysis (WGCNA) and differential expression analysis...
2024: Journal of Prevention of Alzheimer's Disease
#28
JOURNAL ARTICLE
Shiyu Hu, Jingjing Cai, Sizhan Chen, Yang Wang, Lijie Ren
BACKGROUND: Ischemic stroke (IS) is one of most common causes of disability in adults worldwide. However, there is still a lack of effective and reliable diagnostic markers and therapeutic targets in IS. Furthermore, immune cell dysfunction plays an important role in the pathogenesis of IS. Hence, in-depth research on immune-related targets in progressive IS is urgently needed. METHODS: Expression profile data from patients with IS were downloaded from the Gene Expression Omnibus (GEO) database...
March 2024: Biochemistry and Biophysics Reports
#29
JOURNAL ARTICLE
Lu Xiao, Shudian Lin, Feng Zhan
Evidence shows that primary gout is prone to develop to atherosclerosis, but the mechanism of its occurrence is still not fully clarified. The aim of this study was to explore the molecular mechanism of the occurrence of this complication in gout. The gene expression profiles of primary gout and atherosclerosis were downloaded from the gene expression omnibus database. Overlapping differentially expressed genes (DEGs) between gout and atherosclerosis were identified. The biological roles of common DEGs were explored through enrichment analyses...
February 18, 2024: Scientific Reports
#30
JOURNAL ARTICLE
Tao Zhu, Linlin Zhu, Caixia Sheng, Danju Wu, Qianru Gu, Zhinong Jiang, Jiaqi Xu, Guoxiang Fu, Yujie Jiang
BACKGROUND AND AIMS: We aimed to investigate the immune characteristics of intestinal CD8+ gamma delta T (CD8+ γδ T) cells in Crohn's disease (CD) and their correlation with disease activity. METHODS: The study cohorts included 21 CD patients and 21 healthy individuals. CD8+ γδ T cells were isolated from human ileal mucosa for detection by flow cytometry. The activation or inhibition status of cells was detected by detecting the expression of activation marker HLA-DR and the immunosuppressive molecule PD-1 on cells...
February 9, 2024: BMC Immunology
#31
JOURNAL ARTICLE
Michael J Diaz, Jessica Quach, Joanna Song, Silvija Milanovic, Jasmine T Tran, Lauren C Ladehoff, Sai Batchu, Patrick Whitman, Benajmin H Kaffenberger, Marjorie E Montanez-Wiscovich
Hypoxia has established associations with aggressive tumor phenotypes in many cancers. However, it is not currently understood whether tumor hypoxia levels map to distinct immune infiltrates in cutaneous melanoma, potentially unveiling novel therapeutic targets. To this end, we leveraged a previously identified seven-gene hypoxia signature to grade hypoxia levels of 460 cutaneous melanomas obtained from the Broad Institute GDAC Firehose portal. CIBERSORTx (https://cibersortx.stanford.edu/) was employed to calculate the relative abundance of 22 mature human hematopoietic populations...
February 7, 2024: Melanoma Research
#32
JOURNAL ARTICLE
Chinedu A Ugwu, Oluwasina Alao, Oluwagboadurami G John, Blossom Akinnawo, Israel Ajayi, Ooreofe Odebode, Ifeoluwa Bejide, Allan Campbell, Julian Campbell, Jolly A Adole, Idowu B Olawoye, Kazeem Akano, Johnson Okolie, Philomena Eromon, Peter Olaitan, Ajibola Olagunoye, Ibukun Adebayo, Victor Adebayo, Elizabeth Babalola, Omowumi Abioye, Nnennaya Ajayi, Emeka Ogah, Kingsley Ukwaja, Sylvanus Okoro, Ogbonnaya Oje, Ojide Chiedozie Kingsley, Matthew Eke, Venatius Onyia, Olivia Achonduh-Atijegbe, Friday Elechi Ewah, Mary Obasi, Violet Igwe, Olufemi Ayodeji, Abejegah Chukwuyem, Sampson Owhin, Nicholas Oyejide, Sylvester Abah, Winifred Ingbian, Moyosoore Osoba, Ahmed Alebiosu, Angalee Nadesalingam, Ernest T Aguinam, George Carnell, Nina Krause, Andrew Chan, Charlotte George, Rebecca Kinsley, Paul Tonks, Nigel Temperton, Jonathan Heeney, Christian Happi
INTRODUCTION: One of the unexpected outcomes of the COVID-19 pandemic was the relatively low levels of morbidity and mortality in Africa compared to the rest of the world. Nigeria, Africa's most populous nation, accounted for less than 0.01% of the global COVID-19 fatalities. The factors responsible for Nigeria's relatively low loss of life due to COVID-19 are unknown. Also, the correlates of protective immunity to SARS-CoV-2 and the impact of pre-existing immunity on the outcome of the COVID-19 pandemic in Africa are yet to be elucidated...
2024: Frontiers in Immunology
#33
JOURNAL ARTICLE
Swayam Prakash, Nisha R Dhanushkodi, Latifa Zayou, Izabela Coimbra Ibraim, Afshana Quadiri, Pierre Gregoire Coulon, Delia F Tifrea, Berfin Suzer, Amin Mohammed Shaik, Amruth Chilukuri, Robert A Edwards, Mahmoud Singer, Hawa Vahed, Anthony B Nesburn, Baruch D Kuppermann, Jeffrey B Ulmer, Daniel Gil, Trevor M Jones, Lbachir BenMohamed
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has created one of the largest global health crises in almost a century. Although the current rate of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has decreased significantly, the long-term outlook of COVID-19 remains a serious cause of morbidity and mortality worldwide, with the mortality rate still substantially surpassing even that recorded for influenza viruses. The continued emergence of SARS-CoV-2 variants of concern (VOCs), including multiple heavily mutated Omicron sub-variants, has prolonged the COVID-19 pandemic and underscores the urgent need for a next-generation vaccine that will protect from multiple SARS-CoV-2 VOCs...
2024: Frontiers in Immunology
#34
JOURNAL ARTICLE
Changhua Ji, Bing Kuang, Bernard S Buetow, Allison Vitsky, Yuanming Xu, Tzu-Hsuan Huang, Javier Chaparro-Riggers, Eugenia Kraynov, Diane Matsumoto
PF-07209960 is a novel bispecific fusion protein composed of an anti-PD-1 antibody and engineered IL-15 cytokine mutein with reduced binding affinity to its receptors. The pharmacokinetics (PK), pharmacodynamics (PD), and toxicity of PF-07209960 were evaluated following once every other week subcutaneous (SC) or intravenous (IV) administration to cynomolgus monkeys in a repeat-dose PKPD (0.01-0.3 mg/kg/dose) and GLP toxicity study (0.1-3 mg/kg/dose). PF-07209960 showed dose dependent pharmacokinetics with a terminal T1/2 of 8 and 13 hours following IV administration at 0...
2024: PloS One
#35
JOURNAL ARTICLE
Akihito Saito, Miho Nara, Takashi Fujishima, Wataru Kuroki, Takaya Yamashita, Takahiro Kobayashi, Sho Ikeda, Akihiro Kitadate, Yoshihiro Kameoka, Naoto Takahashi
The patient was a 21-year-old man who had been diagnosed with Crohn's disease and received infliximab and azathioprine six years earlier. He was admitted with fever and fatigue. Peripheral blood examination showed LDH 2,473 U/l and thrombocytopenia, and contrast-enhanced computed tomography (CT) showed hepatosplenomegaly. Bone marrow biopsy and liver biopsy showed CD4+CD56+TCRγδ＋CD8- atypical cells, leading to a diagnosis of hepatosplenic T-cell lymphoma (HSTCL). The patient was refractory to CHOP and DA-EPOCH, and therefore received cord blood transplantation with myeloablative conditioning...
2024: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
#36
JOURNAL ARTICLE
Tingting Liu, Huanhuan Wang, Daniel Y Kutsovsky, Michael Iskols, Hongjie Chen, Christine Y J Ohn, Nandan Patel, Jing Yang, David J Simon
Inflammation is closely associated with many neurodegenerative disorders. Yet, whether inflammation causes, exacerbates, or responds to neurodegeneration has been challenging to define because the two processes are so closely linked. Here, we disentangle inflammation from the axon damage it causes by individually blocking cytotoxic T cell function and axon degeneration. We model inflammatory damage in mouse skin, a barrier tissue that, despite frequent inflammation, must maintain proper functioning of a dense array of axon terminals...
February 2, 2024: Cell Reports
#37
JOURNAL ARTICLE
Allison C Boone, Raveendra R Kulkarni, Aneg L Cortes, Carissa Gaghan, Javid Mohammed, Tarsicio Villalobos, Javier Esandi, Isabel M Gimeno
Herpesvirus of turkey (HVT) increases activation of T cells in 1-day-old chickens when administered in ovo . This study evaluated whether adding cytosine-guanosine oligodeoxynucleotides (CpG ODNs) to the HVT vaccine could enhance the adjuvant effect of HVT. We used a CpG ODN dose of 10 μ g per egg. The experimental groups were (1) diluent-only control (sham), (2) HVT, (3) HVT+CpG ODN, (4) HVT+non-CpG ODN, (5) CpG ODN, and (6) non-CpG ODN control. Cellular response evaluation included measuring the frequencies of macrophages (KUL01+ MHC-II+ ), gamma delta T cells ( γδ TCR+ MHC-II+ ), CD4+ , and CD8+ T cell subsets, including double-positive (DP) cells...
February 1, 2024: Viral Immunology
#38
(no author information available yet)
[This corrects the article DOI: 10.3389/fimmu.2023.1242306.].
2024: Frontiers in Immunology
#39
JOURNAL ARTICLE
Laura M Cox, Bruna K Tatematsu, Lydia Guo, Danielle S LeServe, Julia Mayrink, Marilia G Oliveira, Dustin Donnelly, Roberta C Fonseca, Luisa Lemos, Toby B Lanser, Ana C Rosa, Juliana R Lopes, Luke A Schwerdtfeger, Gabriela F C Ribeiro, Eduardo L C Lobo, Thais G Moreira, Andre G Oliveira, Howard L Weiner, Rafael M Rezende
Intestinal γδ T cells play an important role in shaping the gut microbiota, which is critical not only for maintaining intestinal homeostasis but also for controlling brain function and behavior. Here, we found that mice deficient for γδ T cells (γδ-/- ) developed an abnormal pattern of repetitive/compulsive (R/C) behavior, which was dependent on the gut microbiota. Colonization of WT mice with γδ-/- microbiota induced R/C behavior whereas colonization of γδ-/- mice with WT microbiota abolished the R/C behavior...
January 26, 2024: Brain, Behavior, and Immunity
#40
JOURNAL ARTICLE
Anne Desmares, Simon Bouzy, Florian Thonier, Julien Goustille, Francisco Llamas-Gutierrez, Franck Genevieve, Laurane Cottin, Lucile Baseggio, Pierre Lemaire, Carinne Lecoq Lafon, Pascale Cornillet-Lefebvre, Anne-Cécile Galoisy, Chantal Brouzes, Emmanuelle Rault, Elodie Dindinaud, Carole Fleury, Florence Blanc-Jouvan, Soraya Wuilleme, Valérie Bardet, Thierry Fest, Thierry Lamy, Mikael Roussel, Mélanie Pannetier, Cédric Pastoret
Not available.
January 25, 2024: Haematologica
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